A METHOD OF SYNTHESIS OF TRANSITION METAL NITRIDES AND THEIR USE WHEN THEY HAVE TWO, THREE OR FOUR METALS AS CATALYSTS FOR THE OXYGEN EVOLUTION REACTION
INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS (Spain)
Inventor
Vidal Ferran, Anton
Romero Navarro, Andrés
Abstract
The invention refers to a hydroformylation catalyst of formula (I), which comprises a rhodium complex. It also refers to a process for preparing the catalyst, and to the use of the catalyst in hydroformylation reactions which show higher regioselectivity in favor or linear aldehydes, as well as higher conversion yields. It also refers to a ligand and a process for preparing the ligand.It refers also to a process for preparing aldehydes by a hydroformylation reaction.
A new process for the diamination of alkenes is provided, as well as the new compounds prepared thereof. A process for the preparation of the primary amines obtained from the diaminated alkenes of the provided preparation process is also provided.
C07D 275/06 - Heterocyclic compounds containing 1, 2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
C07C 209/60 - Preparation of compounds containing amino groups bound to a carbon skeleton by condensation or addition reactions, e.g. Mannich reaction, addition of ammonia or amines to alkenes or to alkynes or addition of compounds containing an active hydrogen atom to Schiff's bases, quinone imines, or aziranes
It is provided a process for the preparation of (-)-englerin A, as well as analogous compounds thereof, the process comprising transforming a compound of formula (II) wherein PG1 is an ether protective group, through a sequence of reactions comprising deprotection or protection of one or more of the alcohol moieties and formation of an ester, ether, carbonate, carbamate, or thiocarbamate of the alcohol moieties, the different reactions being carried out in any order. Some of the intermediates employed in this process are novel compounds and are included as part of the invention. It is also provided, new analogous compounds of (-)-englerin A, which are useful in the treatment of cancer, as well as pharmaceutical compositions comprising them.
A61K 31/35 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
Compounds of formula (I) or theirs salts, where Y is a (C1-C4)alkyl biradical and n is 1 or 0; M is Cu, Ag, Au, V, Fe, Zn, Ni, Co, Mn, Ru, or Cr; R1 is a known ring system with 1 -2 rings, isolated or fused; each ring having 5-6 members independently selected from C, N, O, S, CH, CH2, and NH, the rings being saturated, partially unsaturated or aromatic, and optionally being substituted by at least one radical selected: halogen, nitro, cyano, (C1-C4)alkyl, halo-(C1-C4)alkyl, -O-(C1-C4)alkyl. -CO-(C1-C4)alkyl, - COO-(C1-C4)alkyl, -OC(O)-(C1-C4)alkyl, -C(O)NR4R5, -(C1-C4)alkyl-NR4R5, -S- (C1-C4)alkyl, -SO-(C1-C4)alkyl, -SO2-(C1-C4)alkyl, -NHSO2-(C1-C4)alkyl, -SO2- NR4R5, and -NR4R5; R2 is -OR3, wherein R3 is selected from the group consisting of hydrogen, benzyl, and an hydroxyl protective group, or a polymeric support, optionally including a linker; and R4 and R5 are independently H, (C1-C4)alkyl, (C2-C4)alkenyl, or (C2-C4)alkynyl, optionally substituted by at least one radical selected from halogen, nitro, cyano, and amino; are useful as catalyst, in particular, in a process for the preparation of substituted 1,2,3-triazoles.
INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS (ICREA) (Spain)
Inventor
Vidal I Ferran, Anton
Fernández Pérez, Héctor
Pericàs-Brondo, Miquel A.
Abstract
The invention relates to new phosphine-phosphite ligands for the preparation of a catalyst for the asymmetric hydrogenation of unsaturated hydrocarbon compounds, methods for their preparation and use thereof.
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (Switzerland)
Inventor
Torres Cebada, Tomás
Cid Martín, Juan José
Khaja Nazeerudin, Mohammad
Ho Yum, Jun
Graetzel, Michael
Palomares, Emilio
Abstract
Substituted carboxyphthalocyanines (I), wherein both the tert-butyl and carboxyl groups located in the four isoindole rings are located independently in any of the four positions of the corresponding benzene ring of each isoindole ring, its regioisomers and mixtures thereof, can be used in the manufacture of organic and hybrid solar cells or as a photoactive dyes for molecular photovoltaic devices.
C07D 487/22 - Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups in which the condensed system contains four or more hetero rings
The present invention relates to novel selective hydrogenation gold-based catalysts for carrying out selective hydrogenation of molecules having triple bonds, and optionally also conjugated double bonds and/or triple and double bonds in the same molecule. The catalysts show a high selectivity and activity, and are also stable over time.
C07C 5/08 - Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms by hydrogenation of carbon-to-carbon triple bonds
C07C 7/167 - Purification, separation or stabilisation of hydrocarbonsUse of additives by treatment giving rise to a chemical modification of at least one compound by hydrogenation for removal of compounds containing a triple carbon-to-carbon bond
C10G 45/34 - Selective hydrogenation of the diolefin or acetylene compounds characterised by the catalyst used
9.
N-HETEROCYCLES SUPPORTED ON POLYMERS THROUGH TRIAZOLE OR TETRAZOLE LINKERS FOR ORGANOCATALYTIC APPLICATIONS
The present invention relates to novel organocatalysts for carrying out asymmetric reactions, which are N-heterocycles supported on polymers through triazole or tetrazole linkers. The organocatalysts show a high purity and a high stereoselectivity, and excellent results has been obtained not only with organic solvents but also with water as solvent.
A computer-based method for for predicting the chemical behaviour of a catalyst - substrate system in a chemical process, comprising: (a) Generating 3D quantum descriptors by using a Density Functional Theory based method; (b) Computing the electronic density and electrostatic potential; (c) Building a molecular isosurface; (d) Computing an steric descriptor at each isosurface 3D point; (e) Building predictive spaces by using structural aligning-free methods,- (f) Combining the predictive spaces for the catalyst and the substrate; (g) Building a mathematical equation which matches combined predictive space according and chemical behaviour by using regression methods and (h) Predicting the chemical behaviour of a catalyst - substrate system in a chemical process by using the mathematical equation built in stage g. Alternatively, a computer-based method for designing catalysts with a targeted chemical behaviour in a chemical process.
G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
11.
EFFICIENT SYNTHESIS OF ASYMMETRIC EPOXIDATION CATALYST I
INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS (ICREA) (Spain)
Inventor
Vidal I Ferrán, Antón
Nieto Alonso, Natalia
Mola Porqueras, Pineda
Abstract
A process for the preparation of chiral ketone I from diol II comprising the acetylation of diol II with an acetylating agent, preferably an acetic acid derivative, wherein said acetylation is performed in the presence of a Lewis acid. The process can further comprise additional previous steps, so that chiral ketone I can be prepared in four steps starting from D-fructose. Alternatively, a process for the preparation of chiral ketone V from diol VI comprising the acetylation of diol VI with an acetylating agent, preferably an acetic acid derivative, wherein said acetylation is performed in the presence of a Lewis acid. The process can further comprise additional previous steps, so that chiral ketone V can be prepared starting from L-fructose, L-sorbose or D-arabinose.
INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS (ICREA) (Spain)
Inventor
Vidal I Ferrán, Antón
Nieto Alonso, Natalia
Molas Porqueras, Pineda
Benet-Buchholz, Jordi
Abstract
A compound of formula I and its enantiomeric counterpart V; a process for the preparation of diol I, and alternatively diol V, comprising a) the acetylation of diol II, or respectively diol VI, with an acetylating agent, wherein said acetylation is performed in the presence of a Lewis acid and b) an aqueous work-up of the reaction mixture; and a method for producing an enantiomerically enriched epoxide from an alkene, said method comprising admixing said alkene, a substantially enantiomerically pure chiral diol selected from the group comprising diol I and diol V and an oxidizing agent. The method can further comprise the addition of a phase-transfer catalyst.
INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS (ICREA) (Spain)
Inventor
Pericás Brondo, Miquel A.
Vidal I Ferran, Anton
Jimeno Mollet, Ciril
Rodríguez Escrich, Sergi
Popa Madeleine, Dana
Abstract
A method for the determination of the enantiomeric composition of a chiral compound comprising : a) derivatising said chiral compound with a enantiomerically and diastereomerically pure compound of general formula (I) and b) analysing the resulting mixture by an analytic technique . Formula (I ), wherein Ar is an optionally substituted aromatic or heteroaromatic group
G01N 24/08 - Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
C07B 57/00 - Separation of optically-active organic compounds
14.
METHOD FOR THE ONE-POT PREPARATION OF STABLE NANO-SIZED PARTICLES UNDER MILD CONDITIONS
A method for the one-pot preparation of stable metallic nano-size particles with a narrow size distribution, comprising the decarbonylation of a metallic carbonyl precursor at a mild temperature in the presence of at least one coordinating compound selected from the group consisting of surfactants and coordinating solvents and at least one decarbonylation promotor. The method can further comprise an aging period and/or the isolation of the nano-size particles. Furthermore, a method for coating a substrate with metallic nano-size particles.
B22F 9/30 - Making metallic powder or suspensions thereofApparatus or devices specially adapted therefor using chemical processes with decomposition of metal compounds, e.g. by pyrolysis
B22F 9/24 - Making metallic powder or suspensions thereofApparatus or devices specially adapted therefor using chemical processes with reduction of metal compounds starting from liquid metal compounds, e.g. solutions
patents