Abstract

The invention relates to compounds for use in the modification of compounds comprising nucleic acid sequences (such as oligonucleotides or the like), to modified oligonucleotides, to the delivery of modified oligonucleotides to cells and the like, and to the treatment of conditions by the delivery of modified oligonucleotides. The invention provides pyridine derived phosphoramidites, phosphorothioates, phosphate esters, solid supported equivalents, related oligonucleotides and the delivery of these to cells.

IPC Classes  ?

• C07H 15/26 - Acyclic or carbocyclic radicals, substituted by hetero rings
• C07D 213/81 - AmidesImides
• C07H 19/073 - Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
• C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
• C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
• C07D 213/55 - AcidsEsters
• C07D 213/56 - Amides
• C07D 213/66 - One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulfur, or nitrogen atom, e.g. pyridoxal
• A61K 31/455 - Nicotinic acid, i.e. niacinDerivatives thereof, e.g. esters, amides
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61K 31/7064 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
• A61P 35/00 - Antineoplastic agents