Abstract

The present disclosure relates to a system and a method for identifying, detecting and/or mapping lymph nodes, in particular sentinel lymph nodes, by means of fluorescence imaging. One aspect of the present disclosure relates to a computer implemented method for improving visualization of at least one fluorescent anatomical 5 structure in images of tissue acquired from a subject, the method comprising the steps of receiving fluorescence images of the tissue, and enhancing contrast in the images to improve visualization of fluorescent anatomical structures in the images.

IPC Classes  ?

• G06T 5/94 - Dynamic range modification of images or parts thereof based on local image properties, e.g. for local contrast enhancement
• G06T 7/00 - Image analysis

Abstract

The present disclosure relates to systems and methods for continuously detecting, and optionally classifying, abnormal perfusion patterns in tissue by means of fluorescence imaging. One embodiment relates to a computer implemented method for detecting (and/or identifying) one or more areas having an abnormal perfusion pattern in tissue of a subject, for example during a medical procedure, the method comprising the steps of: continuously acquiring fluorescence images of the tissue, wherein the fluorescence images are associated with a fluorescent output signal correlated with an input signal defined by a series of boluses of at least one fluorescent imaging agent, and wherein the series of boluses is administered with a predefined and/or controlled duration between subsequent boluses, analysing the fluorescence images, identifying at least one tissue area with normal perfusion, defining a normal perfusion pattern (in an intensity domain and) in a time domain, and detecting, in the fluorescence images, possible tissue areas with abnormal (non-normal) perfusion pattern.

IPC Classes  ?

• A61B 5/0275 - Measuring blood flow using tracers, e.g. dye dilution
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/026 - Measuring blood flow

Abstract

Disclosed are systems and methods for continuously detecting, and optionally classifying, abnormal perfusion patterns in tissue by means of fluorescence imaging. A computer implemented method for detecting (and/or identifying) one or more areas having an abnormal perfusion pattern in tissue of a subject, for example during a medical procedure, includes: continuously acquiring fluorescence images of the tissue, wherein the fluorescence images are associated with a fluorescent output signal correlated with an input signal defined by a series of boluses of at least one fluorescent imaging agent, and wherein the series of boluses is administered with a predefined and/or controlled duration between subsequent boluses, analyzing the fluorescence images, identifying at least one tissue area with normal perfusion, defining a normal perfusion pattern (in an intensity domain and) in a time domain, and detecting, in the fluorescence images, possible tissue areas with abnormal (non-normal) perfusion pattern.

IPC Classes  ?

• A61B 5/0275 - Measuring blood flow using tracers, e.g. dye dilution
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/026 - Measuring blood flow

Abstract

A system and a method is disclosed for continuously identifying blood vessels in tissue during fluorescence imaging. Continuously measuring and assessing hemodynamics in tissue in medical procedures using fluorescence imaging may include the administration of the fluorescent agent that is controlled and automated and thereby identifying, mapping and visualizing blood vessels in the tissue. One embodiment relates a computer implemented method for identifying blood vessels in tissue of a subject, e.g. during a medical procedure, the method including the steps of continuously acquiring fluorescence images of the tissue wherein a fluorescent signal is oscillating with a predetermined pattern, and analysing the fluorescence images and the associated oscillating signal thereby continuously identifying blood vessels in the tissue.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

The present disclosure relates to systems and methods for continuously detecting, and optionally classifying, abnormal perfusion patterns in tissue by means of fluorescence imaging. One embodiment relates to a computer implemented method for detecting (and/or identifying) one or more areas having an abnormal perfusion pattern in tissue of a subject, for example during a medical procedure, the method comprising the steps of:continuously acquiring fluorescence images of the tissue, wherein the fluorescence images are associated with a fluorescent output signal correlated with an input signal defined by a series of boluses of at least one fluorescent imaging agent, and wherein the series of boluses is administered with a predefined and/or controlled duration between subsequent boluses, analysing the fluorescence images, identifying at least one tissue area with normal perfusion, defining a normal perfusion pattern (in an intensity domain and) in a time domain, and detecting, in the fluorescence images, possible tissue areas with abnormal (non-normal) perfusion pattern.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/026 - Measuring blood flow
• A61B 5/0275 - Measuring blood flow using tracers, e.g. dye dilution

Abstract

The present disclosure relates to systems and methods for continuously detecting, and optionally classifying, abnormal perfusion patterns in tissue by means of fluorescence imaging. One embodiment relates to a computer implemented method for detecting (and/or identifying) one or more areas having an abnormal perfusion pattern in tissue of a subject, for example during a medical procedure, the method comprising the steps of:continuously acquiring fluorescence images of the tissue, wherein the fluorescence images are associated with a fluorescent output signal correlated with an input signal defined by a series of boluses of at least one fluorescent imaging agent, and wherein the series of boluses is administered with a predefined and/or controlled duration between subsequent boluses, analysing the fluorescence images, identifying at least one tissue area with normal perfusion, defining a normal perfusion pattern (in an intensity domain and) in a time domain, and detecting, in the fluorescence images, possible tissue areas with abnormal (non-normal) perfusion pattern.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/026 - Measuring blood flow
• A61B 5/0275 - Measuring blood flow using tracers, e.g. dye dilution

Abstract

The present disclosure relates to a system and a method for automatically measuring and assessing hemodynamics in tissue of an anatomical structure of a subject. In particular the present disclosure relates to continuously measuring and assessing hemodynamics in medical procedures using fluorescence imaging and wherein the administration of the fluorescent agent is controlled and automated. One aspect relates to a method of automatic perfusion assessment of an anatomical structure of a subject, the method comprising administration into a vein of a bolus corresponding to less than 0.005 mg ICG/kg body weight of a first fluorescence imaging agent. Another aspect relates to a system for automatic perfusion assessment of an anatomical structure during a medical procedure of a subject comprising a controllable injection pump for holding at least one first fluorescence imaging agent, the injection pump being configured for injecting a predefined amount of said first fluorescence imaging agent into the blood of the subject, wherein the system is configured for receiving and analysing a time series of fluorescence images of the tissue of said anatomical structure following the injection of the first fluorescence imaging agent, and determining at least one perfusion parameter of said anatomical structure based on said analysis.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
• A61M 5/142 - Pressure infusion, e.g. using pumps
• A61B 5/0275 - Measuring blood flow using tracers, e.g. dye dilution

Abstract

The present disclosure relates to a system and a method for continuously identifying blood vessels in tissue during fluorescence imaging. In particular the present disclosure relates to continuously measuring and assessing hemodynamics in tissue in medical procedures using fluorescence imaging wherein the administration of the fluorescent agent is controlled and automated and thereby identifying, mapping and visualizing blood vessels in the tissue. One embodiment relates a computer implemented method for identifying blood vessels in tissue of a subject, e.g. during a medical procedure, the method comprising the steps of continuously acquiring fluorescence images of the tissue wherein a fluorescent signal is oscillating with a predetermined pattern, and analysing the fluorescence images and the associated oscillating signal thereby continuously identifying blood vessels in the tissue.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/026 - Measuring blood flow
• A61B 5/0275 - Measuring blood flow using tracers, e.g. dye dilution

Abstract

The present disclosure relates to a system and a method for continuously identifying blood vessels in tissue during fluorescence imaging. In particular the present disclosure relates to continuously measuring and assessing hemodynamics in tissue in medical procedures using fluorescence imaging wherein the administration of the fluorescent agent is controlled and automated and thereby identifying, mapping and visualizing blood vessels in the tissue. One embodiment relates a computer implemented method for identifying blood vessels in tissue of a subject, e.g. during a medical procedure, the method comprising the steps of continuously acquiring fluorescence images of the tissue wherein a fluorescent signal is oscillating with a predetermined pattern, and analysing the fluorescence images and the associated oscillating signal thereby continuously identifying blood vessels in the tissue.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/026 - Measuring blood flow
• A61B 5/0275 - Measuring blood flow using tracers, e.g. dye dilution

Abstract

The present disclosure relates to a system and a method for automatically measuring and assessing hemodynamics in tissue of an anatomical structure of a subject. In particular the present disclosure relates to continuously measuring and assessing hemodynamics in medical procedures using fluorescence imaging and wherein the administration of the fluorescent agent is controlled and automated. One aspect relates to a method of automatic perfusion assessment of an anatomical structure of a subject, the method comprising administration into a vein of a bolus corresponding to less than 0.005 mg ICG/kg body weight of a first fluorescence imaging agent.

IPC Classes  ?

• A61B 5/0275 - Measuring blood flow using tracers, e.g. dye dilution
• A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/026 - Measuring blood flow
• G01N 21/64 - FluorescencePhosphorescence

Abstract

A system and a method for automatically and continuously measuring and assessing hemodynamics uses fluorescence imaging in which the fluorescent agent is controlled and automated. A method of automatic perfusion assessment of an anatomical structure of a subject includes administration into a vein of a bolus corresponding to less than 0.01 mg ICG/kg body weight of a first fluorescence imaging agent. A system for automatic perfusion assessment during a medical procedure includes a controllable injection pump for holding at least one first fluorescence imaging agent, the injection pump being configured for injecting a predefined amount of the first fluorescence imaging agent into the blood. The system is configured for receiving and analysing a time series of fluorescence images and determining at least one perfusion parameter based on the analysis.

IPC Classes  ?

• A61B 5/0275 - Measuring blood flow using tracers, e.g. dye dilution
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/026 - Measuring blood flow
• A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
• A61K 49/00 - Preparations for testing in vivo

Abstract

The present disclosure relates to a system and a method for automatically measuring and assessing hemodynamics in tissue of an anatomical structure of a subject. In particular the present disclosure relates to continuously measuring and assessing hemodynamics in medical procedures using fluorescence imaging and wherein the administration of the fluorescent agent is controlled and automated. One aspect relates to a method of automatic perfusion assessment of an anatomical structure of a subject, the method comprising administration into a vein of a bolus corresponding to less than 0.01 mg ICG/kg body weight of a first fluorescence imaging agent. Another aspect relates to a system for automatic perfusion assessment of an anatomical structure during a medical procedure of a subject comprising a controllable injection pump for holding at least one first fluorescence imaging agent, the injection pump being configured for injecting a predefined amount of said first fluorescence imaging agent into the blood of the subject, wherein the system is configured for receiving and analysing a time series of fluorescence images of the tissue of said anatomical structure following the injection of the first fluorescence imaging agent, and determining at least one perfusion parameter of said anatomical structure based on said analysis.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/026 - Measuring blood flow
• A61B 5/0275 - Measuring blood flow using tracers, e.g. dye dilution

Abstract

The present disclosure relates to a system and a method for automatically measuring and assessing hemodynamics in tissue of an anatomical structure of a subject. In particular the present disclosure relates to continuously measuring and assessing hemodynamics in medical procedures using fluorescence imaging and wherein the administration of the fluorescent agent is controlled and automated. One aspect relates to a method of automatic perfusion assessment of an anatomical structure of a subject, the method comprising administration into a vein of a bolus corresponding to less than 0.01 mg ICG/kg body weight of a first fluorescence imaging agent. Another aspect relates to a system for automatic perfusion assessment of an anatomical structure during a medical procedure of a subject comprising a controllable injection pump for holding at least one first fluorescence imaging agent, the injection pump being configured for injecting a predefined amount of said first fluorescence imaging agent into the blood of the subject, wherein the system is configured for receiving and analysing a time series of fluorescence images of the tissue of said anatomical structure following the injection of the first fluorescence imaging agent, and determining at least one perfusion parameter of said anatomical structure based on said analysis.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• A61B 5/026 - Measuring blood flow
• A61B 5/0275 - Measuring blood flow using tracers, e.g. dye dilution

Abstract

The present disclosure relates to a system for measuring and assessing hemodynamics in an anatomical structure of a subject, and a method for image processing hemodynamics in at least a part of an anatomical structure in video images acquired from a subject. In particular the present disclosure relates to measuring and assessing hemodynamics in, around and near the surface, in particular the gastrointestinal wall, of the gastrointestinal tract of a subject. One embodiment discloses a method for image processing hemodynamics in at least a part of an anatomical structure in video images acquired from a subject, comprising the steps of: performing image analysis of at least one video sequence acquired after a fluorescent contrast agent has been supplied to the subject, calculating intensity values in one or more regions of interest based on the image analysis, and determining the perfusion slope of the flow of the fluorescent contrast agent through at least one of said regions of interest.

IPC Classes  ?

• A61B 5/0275 - Measuring blood flow using tracers, e.g. dye dilution