ISTITUTO NAZIONALE DI GENETICA MOLECOLARE - INGM (Italy)
Inventor
Di Fabio, Romano
Summa, Vincenzo
Bencheva, Leda Ivanova
De Francesco, Raffaele
Donnici, Lorena
Guidotti, Luca
Iannacone, Matteo
Prandi, Adolfo
De Matteo, Marilenia
Randazzo, Pietro
Abstract
The present invention relates to compounds that are inhibitors of hepatitis B virus (HBV). Compounds of this invention are useful alone or in combination with other agents for treating, ameliorating preventing or curing HBV infection and related conditions. The present invention also relates to pharmaceutical compositions containing said compounds.
A61K 31/554 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and at least one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
ISTITUTO NAZIONALE DI GENETICA MOLECOLARE - INGM (Italy)
OSPEDALE SAN RAFFAELE S.R.L. (Italy)
IRBM S.P.A. (Italy)
PROMIDIS S.R.L. (Italy)
Inventor
De Francesco, Raffaele
Donnici, Lorena
Guidotti, Luca
Iannacone, Matteo
Di Fabio, Romano
Summa, Vincenzo
Prandi, Adolfo
Randazzo, Pietro
Ivanova Bencheva, Leda
De Matteo, Marilenia
Ferrante, Luca
Gornati, Davide
Grillo, Alessandro
Abstract
The present invention relates to compounds that are inhibitors of hepatitis B virus (HBV). Compounds of this invention are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The present invention also relates to pharmaceutical compositions containing said compounds.
A61K 31/407 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
ISTITUTO NAZIONALE DI GENETICA MOLECOLARE - INGM (Italy)
Inventor
De Francesco, Raffaele
Donnici, Lorena
Guidotti, Luca
Iannacone, Matteo
Di Fabio, Romano
Summa, Vincenzo
Prandi, Adolfo
Randazzo, Pietro
Gornati, Davide
Grillo, Alessandro
Ferrante, Luca
Bencheva, Leda Ivanova
De Matteo, Marilenia
Ferrara, Marco
Abstract
The present invention relates to compounds that are inhibitors of hepatitis B virus (HBV). Compounds of this invention are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The present invention also relates to pharmaceutical compositions containing said compounds.
C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
A61K 31/554 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and at least one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
ISTITUTO NAZIONALE DI GENETICA MOLECOLARE - INGM (Italy)
Inventor
De Francesco, Raffaele
Prandi, Adolfo
Randazzo, Pietro
Donnici, Lorena
Guidotti, Luca
Iannacone, Matteo
Di Fabio, Romano
Summa, Vincenzo
Bencheva, Leda Ivanova
De Matteo, Marilenia
Ferrante, Luca
Abstract
The present invention relates to compounds that are inhibitors of hepatitis B virus (HBV). Compounds of this invention are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The present invention also relates to pharmaceutical compositions containing said compounds.
C07D 213/74 - Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
A61K 31/337 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
A61K 31/4025 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
C07D 213/76 - Nitrogen atoms to which a second hetero atom is attached
C07C 311/44 - Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
C07D 207/14 - Nitrogen atoms not forming part of a nitro radical
C07D 211/58 - Nitrogen atoms attached in position 4
C07D 305/08 - Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring atoms
ISTITUTO NAZIONALE DI GENETICA MOLECOLARE - INGM (Italy)
Inventor
De Francesco, Raffaele
Donnici, Lorena
Guidotti, Luca
Iannacone, Matteo
Di Fabio, Romano
Summa, Vincenzo
Bencheva, Leda Ivanova
De Matteo, Marilenia
Ferrante, Luca
Prandi, Adolfo
Randazzo, Pietro
Abstract
The present invention relates to compounds that are inhibitors of hepatitis B virus (HBV). Compounds of this invention are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The present invention also relates to pharmaceutical compositions containing said compounds.
A61K 31/407 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine
C07D 285/28 - 1,2,4-ThiadiazinesHydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom substituted in position 6 or 7 by sulfamoyl or substituted sulfamoyl radicals with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached in position 3
C07D 291/08 - Heterocyclic compounds containing rings having nitrogen, oxygen and sulfur atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
patents