C07C 43/247 - Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring and to a carbon atom of a ring, other than a six-membered aromatic ring containing halogen
C07C 211/26 - Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
C07F 9/12 - Esters of phosphoric acids with hydroxyaryl compounds
A61K 31/136 - Amines, e.g. amantadine having aromatic rings, e.g. methadone having the amino group directly attached to the aromatic ring, e.g. benzeneamine
A61K 31/09 - Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
A61K 31/661 - Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion
Disclosed are a CA-4 antitumour drug, a synthesis method and the use thereof. The CA-4 antitumour drug introduces an alkoxy group or a fluorine-containing alkoxy group at the 4' position of a natural product, i.e., combretastatin, and carries out functional chemical modification at the 3' position thereof. The CA-4 antitumour drug of the present invention has an inhibitory ability for the two targets of tubulin and aryl sulfatase and can be used for antitumour therapy.
C07C 307/02 - Monoamides of sulfuric acids or esters thereof, e.g. sulfamic acids
C07C 303/34 - Preparation of esters or amides of sulfuric acidsPreparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfuric acids
A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
in vitroin vitro, with the introduction of the difluoromethyl changing the physical, chemical and biological properties of the compounds, and have a significant inhibitory effect on tumour cells.
C07C 217/84 - Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton having amino groups and etherified hydroxy groups bound to carbon atoms of non-condensed six-membered aromatic rings of the same non-condensed six-membered aromatic ring the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
C07C 43/23 - Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
C07F 9/12 - Esters of phosphoric acids with hydroxyaryl compounds
A61K 31/136 - Amines, e.g. amantadine having aromatic rings, e.g. methadone having the amino group directly attached to the aromatic ring, e.g. benzeneamine
A61K 31/09 - Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
A61K 31/661 - Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion
patents