A substituted pyrazole compound represented by formula I, and a preparation method, a pharmaceutical composition, and use thereof. The compound has good stability, excellent solubility, small cell toxicity, and a significant effect on neuroprotection, can effectively prevent and treat nerve cell damages, and is an ideal pharmaceutical compound for preventing or treating cerebral apoplexy, cerebral embolism, cerebral apoplexy sequelae, cerebral apoplexy motion dysfunction, mitochondria brain myopathy, and amyotrophic lateral sclerosis. (I)
C07D 231/22 - One oxygen atom attached in position 3 or 5 with aryl radicals attached to ring nitrogen atoms
C07H 17/02 - Heterocyclic radicals containing only nitrogen as ring hetero atoms
A61K 31/4152 - 1,2-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. antipyrine, phenylbutazone, sulfinpyrazone
A61K 31/7056 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
2.
CYCLOBUTANE DICARBOXYLIC ACID PLATINUM COMPLEX AND INTERMEDIARY, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND USE THEREOF
A cyclobutane dicarboxylic acid platinum complex shown in formula (I) and an intermediary, a preparation method, a pharmaceutical composition, and a use thereof. The cyclobutane dicarboxylic acid platinum complex has good anti-tumour activity. The complex provided in the present invention has a water solubility several dozen times higher than existing platinum anti-tumour drugs; the feature of high water solubility can increase and improve the excretion of drugs in the kidneys and alleviate the high renal toxicity side effects normally present for platinum drugs; the compounds are easily formulated and more convenient for clinical application.
A vitamin C-platinum complex as shown in formula (I), an intermediate thereof, a preparation method, a pharmaceutical composition and a use. The vitamin C-platinum complex has good anti-tumour activity. The complex of the present invention is dozens of times better than existing platinum-type anti-tumour drugs in terms of water solubility. The high water solubility can increase and improve drug excretion in the kidneys, and reduce the high renal toxic side effects which generally occur with platinum-type drugs. In addition, the compound is easy to formulate, and more convenient for clinical application.
Disclosed are a water-soluble platinum coordination complex for tumour treatment and a preparation method therefor, said coordination complex being shown as formula (I): The present platinum coordination complex shows a long-term antineoplastic effect superior to that of oxaliplatin, while the enhanced stability and solubility of the preparation favor its clinical use.
Provided are a fluorine-containing, water-soluble platinum complex for treating tumors and a preparation method therefor. The complex is represented in formula (I). Experiments show that the complex of the present invention and medications prepared using the complex of the present invention have high water solubility and tumor target effects, and are convenient for clinical use.
Disclosed are a water-soluble fluorine-containing platinum coordination complex for tumour treatment and a preparation method therefor, said coordination complex being shown as formula (I): The present platinum coordination complex shows a long-term antineoplastic effect superior to that of oxaliplatin, while the enhanced stability and solubility of the preparation favor its clinical use.
Disclosed in the present invention is the use of a water soluble platinum coordination complex in preparing drugs for the prevention and treatment of tumours, said coordination complex being shown as formula (I). Experiments have demonstrated that the present platinum complex is able to prevent and treat cancer in mammals, and in particular, humans, said cancers including lung cancer, colorectal cancer, head and neck cancer, prostate cancer, mammary gland cancer, ovary cancer, cancer of the cervix, leukemia, lymphatic cancer, skin cancer, pancreatic gland cancer, liver cancer, bladder cancer, esophagus cancer, stomach cancer, male genital organ cancer, osteo-carcinoma and so on.
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