The present disclosure is directed to the removal of contaminants from a contaminated surface in the field. According to one embodiment, the present disclosure is directed to a textile comprising immobilized contaminant surface removal media for contacting a contaminated surface and removal of contamination. According to a further embodiment, the present disclosure is directed to a hand mitt comprising at least one outward facing textile side comprising immobilized contaminant surface removal media. According to another embodiment, the present disclosure is directed to a process for the removal of contaminants from a surface comprising contacting a contaminated surface with a textile comprising immobilized contaminant surface removal media and thereafter disposing of the textile including removed contaminants.
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
A62D 3/30 - Processes for making harmful chemical substances harmless, or less harmful, by effecting a chemical change in the substances by reacting with chemical agents
A62D 101/02 - Chemical warfare substances, e.g. cholinesterase inhibitors
B01J 20/08 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group comprising aluminium oxide or hydroxideSolid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group comprising bauxite
B01J 20/20 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising free carbonSolid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising carbon obtained by carbonising processes
2.
Removing Toxic Chemicals from Contaminated Surfaces
A process comprising: contacting an item with a dry media to remove a first portion of a chemical warfare agent from the item; contacting the item with solvent to contaminate the solvent with a second portion of the chemical warfare agent from the item; and removing the contaminated solvent from the item. A device comprising: a first side comprising a dry media applicator to remove a first portion of a chemical warfare agent from an item; and a second side comprising an absorptive material to remove a solvent contaminated with a second portion of a chemical warfare agent from the item, wherein the first and second sides are of a unitary whole.
A62D 3/33 - Processes for making harmful chemical substances harmless, or less harmful, by effecting a chemical change in the substances by reacting with chemical agents by chemically fixing the harmful substance, e.g. by chelation or complexation
A62D 101/02 - Chemical warfare substances, e.g. cholinesterase inhibitors
B01J 20/06 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
A device for concentrating and preserving samples for subsequent analysis, wherein the samples include but are not limited to, biological samples, environmental samples, industrial samples, and the like. The present disclosure further includes a method for utilizing the device for containment, concentration, and preservation of the sample until analysis can take place. The disclosed device is simple to operate and can function without auxiliary equipment and/or sources of power making it particularly suitable for use in locations distanced and isolated from analytical facilities.
The current disclosure provides compositions and methods for treating and/or debriding damaged or dying tissue resulting from a range of injuries and conditions without requiring surgical personnel or facilities. The compositions can be utilized in the field close to where the injury occurred. The compositions include a covalently bonded and immobilized protease enzyme included in a medium that can have a variety of forms and further include a range of additives to further effect the safe and effective removal of dead or damaged tissue. The compositions can be transported and utilized in the field without refrigeration and without any special handling.
C12N 9/96 - Stabilising an enzyme by forming an adduct or a compositionForming enzyme conjugates
A61K 47/58 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
The current disclosure provides compositions and methods for treating and/or debriding damaged or dying tissue resulting from a range of injuries and conditions without requiring surgical personnel or facilities. The compositions can be utilized in the field close to where the injury occurred. The compositions include a covalently bonded and immobilized protease enzyme included in a medium that can have a variety of forms and further include a range of additives to further effect the safe and effective removal of dead or damaged tissue. The compositions can be transported and utilized in the field without refrigeration and without any special handling.
Current methods for detection of microbial contaminants on surfaces use swabbing/wiping to extract microbes for analysis. This removes easily transferable microbes but fails to extract microbes living in biofilms, which reduces sensitivity and may mask the true degree of contamination. The current disclosure provides an enzyme cocktail that disrupts the biofilm and improves the extraction of live microbes for analysis. Applicant's enzyme system is particularly useful for the application to a variety of surfaces, but particularly on a variety of food processing surfaces. Utilization of Applicant's enzyme cocktail makes possible the extraction of a representative sample of live microorganisms present on a surface, including film forming microorganisms, without affecting non-film forming microorganisms also present on a surface.
A01N 25/02 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
A61P 31/00 - Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
Current methods for detection of microbial contaminants on surfaces use swabbing/wiping to extract microbes for analysis. This removes easily transferable microbes but fails to extract microbes living in biofilms, which reduces sensitivity and may mask the true degree of contamination. The current disclosure provides an enzyme cocktail that disrupts the biofilm and improves the extraction of live microbes for analysis. Applicant's enzyme system is particularly useful for the application to a variety of surfaces, but particularly on a variety of food processing surfaces. Utilization of Applicant's enzyme cocktail makes possible the extraction of a representative sample of live microorganisms present on a surface, including film forming microorganisms, without affecting non-film forming microorganisms also present on a surface.
A device for concentrating and preserving samples for subsequent analysis, wherein the samples include but are not limited to, biological samples, environmental samples, industrial samples, and the like. The present disclosure further includes a method for utilizing the device for containment, concentration, and preservation of the sample until analysis can take place. The disclosed device is simple to operate and can function without auxiliary equipment and/or sources of power making it particularly suitable for use in locations distanced and isolated from analytical facilities.
Gas recycling system comprised primarily of pressure swing adsorption equipment for the recovery, purification and return of gases in industrial applications
Gas recycling system comprised primarily of pressure swing adsorption equipment for the recovery, purification and return of gases in industrial applications
The United States Government as Represented by the Secretary of the Army (USA)
Inventor
Anderson, Erin
Rossin, Rachel
Rossin, Joseph
Knapke, Michael
Pomerantz, Natalie
Abstract
The present invention relates to a textile composite for the adsorption and breakdown of harmful chemical materials. A support layer and a sorptive and reactive material mounted on the support layer form a protective layer, which is mounted on an inner liner. The protective layer adsorbs and breaks down harmful chemical materials. An outer shell is formed of fabric having an outer surface that is hydrophobic for resisting the passage of harmful chemicals, which may be in the form of vapor, liquid or aerosols. Preferably, the sorptive and reactive material includes zirconium hydroxide, and the support layer includes a fabric material. The zirconium hydroxide is distributed on the fabric material in the amount of at least 20 grams of zirconium hydroxide per square meter. Alternatively, the zirconium hydroxide is distributed in the amount of at least 150 or 200 grams of zirconium hydroxide per square meter.
B32B 19/06 - Layered products essentially comprising natural mineral fibres or particles, e.g. asbestos, mica next to a fibrous or filamentary layer
B32B 7/12 - Interconnection of layers using interposed adhesives or interposed materials with bonding properties
B32B 5/26 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by the presence of two or more layers which comprise fibres, filaments, granules, or powder, or are foamed or specifically porous one layer being a fibrous or filamentary layer another layer also being fibrous or filamentary
Various embodiments may include a system for removing contaminants from contaminated water comprising: a distillation still supplying heat to contaminated water to boil the contaminated water; a vent allowing a vapor stream to exit the distillation still; an oxidation unit removing additional contaminants from the vapor stream; an outlet discharging a purified water stream from the oxidation unit; and a heat exchanger transferring heat from the purified water stream leaving the oxidation unit to the vapor stream exiting the distillation still before the vapor stream enters the oxidation unit.
2S, the processes comprise contacting the gas streams with a mixed metal oxy-hydroxide media comprising two or more metals selected from the group consisting of iron, copper and silicon.
B01D 53/02 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
B01D 53/04 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
B01D 53/34 - Chemical or biological purification of waste gases
Methods for determining bacterial identity and susceptibility or resistance to antibiotic or antimicrobial agents are provided. In one embodiment, the bacteria is cultured in the presence or absence or the antibiotic agent to generate a plurality of primary cultures, which are then cultured in the presence or absence of transforming phages to generate a first secondary culture that comprise transformed bacteria that have been treated with the antibiotic agent and a second secondary culture that comprises transformed bacteria that have not been treated with the antibiotic agent. The recombinant phages are specific to the bacteria and comprise a heterologous marker. The susceptibility or resistance of the bacteria to the antibiotic or antimicrobial agent is determined by comparing a level or activity of the marker in the first and second secondary cultures.
C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
C12Q 1/18 - Testing for antimicrobial activity of a material
C12Q 1/34 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase
C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
The present invention provides processes for filtering undesired chemicals in streams of contaminated air for supply to confined areas. The processes provide (1) contacting air with a filter comprising by volume from about 5% to about 95% impregnated zirconium hydroxide, from about 5% to about 95% activated impregnated carbon, and optionally, up to about 50% ammonia removal material; and (2) supplying the contacted air to a confined area.
A61L 9/00 - Disinfection, sterilisation or deodorisation of air
B01D 46/00 - Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
B01D 53/82 - Solid phase processes with stationary reactants
B01D 53/04 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
B01J 20/20 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising free carbonSolid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising carbon obtained by carbonising processes
B01J 20/06 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group
B01J 20/22 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising organic material
B01J 20/02 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
2S, the processes comprise contacting the gas streams with a mixed metal oxy-hydroxide media comprising one or more metals selected from the group listed above plus one or more metals selected from the group consisting of aluminum, silicon, titanium and zirconium.
B01D 53/04 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
B01D 53/34 - Chemical or biological purification of waste gases
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (USA)
GUILD ASSOCIATES INC. (USA)
Inventor
Rossin, Joseph A.
Peterson, Gregory W.
Buechter, William F.
Abstract
2), hydrogen cyanide (HCN), and others. A reactive media includes: a porous metal oxy-hydroxide including at least one first transition metal that is optionally one or more of copper, zinc, or iron; a second transition metal linked to the first transition metal by a bond that includes an oxygen, the second transition metal selected optionally being one or more of magnesium, calcium, cobalt, titanium, zirconium, aluminum, and silicon; and the metal oxy-hydroxide terminated by at least one hydroxyl group. The resulting media provides for excellent porosity and reactivity for removal of toxic chemicals from the environment or a sample.
B01J 20/10 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
B01J 20/06 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group
B01J 20/08 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group comprising aluminium oxide or hydroxideSolid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group comprising bauxite
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
B01D 53/02 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
20.
Biodegradable immobilized enzymes and methods of making the same
The present application discloses immobilized enzymes and immobilized enzyme materials comprising a crosslinked enzyme having a support material which includes a biomass material different than the biomass used to initially derive the enzyme. Optionally, the immobilized enzyme further includes a polymeric material and/or the biomass which was used to initially derive the enzyme. The resulting immobilized enzyme materials may be biodegradable. The present application also discloses methods of making and using the disclosed immobilized enzyme materials.
The invention relates to a method for utilizing low-quality tail gas derived from a pressure swing adsorption system or membrane system, which is used to upgrade biogas, as a beneficial fuel for the facility and/or digester boiler.
C12N 15/00 - Mutation or genetic engineeringDNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purificationUse of hosts therefor
C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
C12Q 1/66 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving luciferase
C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
23.
PHAGE-MEDIATED BIOLUMINESCENT DETECTION OF YERSINIA PESTIS
The present disclosure relates to compositions, methods, systems and kits for the detection of microorganisms of the Yersinia species including Yersinia pestis. The disclosure relates to recombinant phage operable to infect a Yersinia microorganism, the phage comprising a detectable reporter. Detection systems of the disclosure may comprise a phage operable to infect a Yersinia microorganism, and may comprise a reporter nucleic acid expressible upon infection of a Yersinia microorganism by the phage. The system may be operable to detect the expression of the reporter. A detectable reporter may comprise any gene having bioluminescent, colorimetric and/or visual detectability. For example, a detectable reporter may comprise one or more luxAB genes detectable by emission, enhancement and/or change in spectrum of bioluminescent light. Live and infectious Yersinia microbes may be detected by the compositions, methods, systems and kits described herein.
C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms
C12Q 1/66 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving luciferase
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
24.
DIFFERENTIALLY FLUORESCENT YEAST BIOSENSORS FOR THE DETECTION AND BIODEGRADATION OF CHEMICAL AGENTS
The present disclosure provides methods, devices, systems and compositions for detecting and/or modifying chemical agents. In some embodiments, a biosensor may be configured to detect a chemical agent, modify that agent to a form with reduced toxicity, and and/or detect the modified form of the chemical agent. The present disclosure also relates, in some embodiments, to variant organophosphorus hydrolase having one or more desirable amino acid substitutions.
The disclosure provides a device for converting a passenger vehicle to a patient transport vehicle including a bracket (10) configured to mount to a seat located in a passenger vehicle, a wear strip (20) attached to the bracket, the wear strip comprising (20) a flat surface configured to support a stretcher (40), and a tie down (30) system configured to releasably attach a stretcher (40) to the bracket (10) when the stretcher is in contact with the wear strip (20).
A61G 1/06 - Supports for stretchers, e.g. to be placed in or on vehicles
A61G 3/00 - Ambulance aspects of vehiclesVehicles with special provisions for transporting patients or disabled persons, or their personal conveyances, e.g. for facilitating access of, or for loading, wheelchairs
The present disclosure, according to some embodiments, relates to phage-based biological detection systems, compositions, and methods. In some embodiments, it relates to a detection system and method using phage binding and bacterial infection to detect the presence of a target molecule (e.g., a toxin). One detection system may include a genetically engineered phage that expresses a surface molecule able to bind a target molecule and/or target microorganism; a bacterium susceptible to infection by the phage; and a detection component able to determine whether the bacterium has been infected by the phage. Infection of a bacterium by a phage may be indicative of phage binding to the target molecule and/or target microorganism. One method may include placing a sample suspected of containing the target molecule and/or target microorganism with a binder; adding a genetically engineered phage having reporter genetic material and able to bind the target molecule and/or target microorganism; washing away unbound phage; releasing phage bound to the target molecule and/or target microorganism; infecting a bacterium with the released phage; and detecting the presence of any reporter genetic material in the bacterium. Reporter material in the bacterium may correlate with target molecule and/or target microorganism in the sample. In some embodiments, the disclosure relates to a detection system and method using phage comprising a reporter to infect a microorganism (e.g., Bacillus anthracis), wherein the reporter is selectively (e.g., only) detectable upon phage infection.
C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
C12Q 1/66 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving luciferase
G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage
27.
YEAST BIOCATALYSTS FOR DEGRADATION OF BIOWARFARE AGENTS
The present disclosure relates to yeast biocatalysts and methods of using yeast biocatalysts for detoxifying a biowarfare agent. In some embodiments, a yeast biocatalyst may include a nucleic acid encoding a phage lysin operably linked to a prepro leader sequence, an expression control sequence operably linked to the nucleic acid, and a bioeffective amount (e.g., enough to detoxify) of the phage lysin. A yeast biocatalyst may include an engineered strain of a Saccharomyces cerevisiae. A phage lysin may be selected from the group consisting of PlyG and PlyPH. A method of detoxifying a biowarfare agent may include contacting a biowarfare agent with a yeast biocatalyst under conditions that permit detoxification. Conditions that permit detoxification, according to some embodiments, may include conditions that permit expression and secretion of a phage lysin. In some embodiments, conditions that permit detoxification may include conditions that permit germination of a spore. For example, a method of detoxifying a biowarfare agent spore may include contacting the spore with growth media (e.g., complete media or complex media) having alanine.
The present disclosure provides methods, devices, systems and compositions for detecting and/or modifying chemical agents. In some embodiments, a biosensor may be configured to detect a chemical agent, modify that agent to a form with reduced toxicity, and and/or detect the modified form of the chemical agent.
