Goods & Services

Computer software and hardware; encoding and decoding apparatus; databases; electronic tablets; smartphones; detectors; data processing equipment; measuring instruments; three dimensional viewers; digital sensory devices; measuring, detecting, monitoring and controlling devices; sensors; microscopes; handheld scanners; audio, visual and photographic devices; digital cameras; monitoring and testing apparatus and instruments; optical apparatus and instruments; optical communications instruments; optical devices, enhancers and correctors; photographic apparatus and instruments; testing and quality control devices; humanoid robots; software converters; telepresence robots; laboratory robots; teaching robots; downloadable computer programs and downloadable computer software; downloadable electronic publications; parts and fittings for the aforesaid goods Scientific research; DNA testing services; Software as a service (SaaS); technical research; research, development, design, installation, maintenance, updating and upgrading of computer software; technical support services; software customisation services; providing non-downloadable computer software; providing temporary use of online non-downloadable computer software; computer hardware design services; design and maintenance of computer software programming of computer software for reading, transmitting and organising data; programming of software for inventory management; rental of software for inventory management; analysis and testing services relating to monitoring and testing apparatus; computer system monitoring services; design of three dimensional displays; monitoring of network systems; product quality checking and testing; quality checking and testing; control of services; testing, authentication and quality control; artificial intelligence technology consultancy; programming of computer software for electronic language translation dictionaries and databases; research in the field of computer natural language processing; research and development services in the field of artificial intelligence; encoding of the biological state of cells and tissues; technological research and consultancy; product research; product development services; platform as a service (PaaS); cloud based services featuring software for customisation, optimisation, utilisation, modelling, and emulation relating to bioprocessing and bioprocess development; design and laboratory development services for the creation of bioprocessing facilities and rooms therein for the life sciences industry; development of digital twins; bioprocess engineering services and engineering process development services; scientific and technological services; testing services, and consultancy relating thereto; consultancy, advisory and information services relating to the aforesaid services Medical services; medical information services; medical screening and testing services; medical analysis for the diagnosis of conditions and treatment of persons; behaviour analysis for medical purposes; remote monitoring of medical data for medical diagnosis and treatment; conducting of medical examination; alternative medical services; healthcare services provided via artificial intelligence; genetic testing for medical purposes; health assessment surveys; performing diagnosis of diseases; information, advisory and consultancy services in relation to all the aforesaid

Abstract

The present disclosure, among other things, provides machine-learning technologies for identifying and localizing particular genomic elements (e.g., gene elements and/or regulatory elements) within nucleotide sequences, such as DNA and/or RNA sequences. In certain embodiments, similar to the manner in which image processing methods can be used to localize particular objects in images at pixel level resolution, referred to as “segmentation,” systems and methods of the present disclosure predict presence and locations of certain genomic elements within nucleotide sequences, thereby “segmenting” nucleotide sequences. Accordingly, genomic element segmentation technologies described herein may be used to generate annotations that identify and label portions of nucleotide sequences according to their predicted (e.g., via machine learning models described herein) function—e.g., as protein-coding genes, untranslated regions, splice sites, promotors, enhancers, etc. Among other things, these genomic annotations may be used to inform underlying biological processes driving diseases and facilitate development of new therapies.

IPC Classes  ?

• G06N 3/123 - DNA computing
• G16B 40/30 - Unsupervised data analysis

Abstract

Provided herein are technologies for framing and evaluating biological sequence-based analysis tasks in a unified, natural-language-based, text in and text out format. Among other things, methods and systems of the present disclosure provide machine-learning technologies for combining biological sequence data, representing, for example, DNA, RNA, and protein sequences, with natural language, conversational style prompts that set out particular analysis tasks to be performed on the biological sequence data. This approach, for example, allows complex analysis tasks, including, but not limited to, identification of various sequence modifications, genes, and regulatory elements in DNA sequences, and quantification of properties such as degradation propensity of RNA and protein stability, to be input to a machine learning model in a uniform text-based format and for output to be generated in a same, unified, text-based format.

IPC Classes  ?

• G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids

Abstract

The present disclosure, among other things, provides machine-learning technologies for identifying and localizing particular genomic elements (e.g., gene elements and/or regulatory elements) within nucleotide sequences, such as DNA and/or RNA sequences. In certain embodiments, similar to the manner in which image processing methods can be used to localize particular objects in images at pixel level resolution, referred to as "segmentation," systems and methods of the present disclosure predict presence and locations of certain genomic elements within nucleotide sequences, thereby "segmenting" nucleotide sequences. Accordingly, genomic element segmentation technologies described herein may be used to generate annotations that identify and label portions of nucleotide sequences according to their predicted (e.g., via machine learning models described herein) function – e.g., as protein-coding genes, untranslated regions, splice sites, promotors, enhancers, etc. Among other things, these genomic annotations may be used to inform underlying biological processes driving diseases and facilitate development of new therapies.

IPC Classes  ?

• G16B 20/30 - Detection of binding sites or motifs
• G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids
• G16B 40/20 - Supervised data analysis

Abstract

Provided herein are technologies for framing and evaluating biological sequence-based analysis tasks in a unified, natural-language-based, text in and text out format. Among other things, methods and systems of the present disclosure provide machine-learning technologies for combining biological sequence data, representing, for example, DNA, RNA, and protein sequences, with natural language, conversational style prompts that set out particular analysis tasks to be performed on the biological sequence data. This approach, for example, allows complex analysis tasks, including, but not limited to, identification of various sequence modifications, genes, and regulatory elements in DNA sequences, and quantification of properties such as degradation propensity of RNA and protein stability, to be input to a machine learning model in a uniform text-based format and for output to be generated in a same, unified, text-based format.

IPC Classes  ?

• G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids
• G06N 3/0455 - Auto-encoder networksEncoder-decoder networks
• G16B 40/30 - Unsupervised data analysis

Goods & Services

Computer software and hardware; software in the field of artificial intelligence; machine learning software; augmented and virtual reality software; electronic tablets; smartphones; predictive analytics software; data analysis software; computer software in the field of pharmaceutical research, biotechnology, bioinformatics and in silico design and testing; data processing equipment; software for data centre optimisation; software in the fields of optimisation and operations research; downloadable computer software incorporating artificial intelligence for collecting, analysing and organising data; software for machine learning intelligent gateways for real-time data analysis; artificial intelligence software; artificial intelligence and machine learning software for machine vision devices. Software as a service [SaaS]; research and development of computer software; scientific research; technical research; design, installation, maintenance, updating and upgrading of computer software; software as a service [SaaS] in the field of artificial intelligence; troubleshooting of computer hardware and software problems; software customisation services; providing non-downloadable computer software; computer hardware design services; customised design of computer software; customised design of computer hardware; software as a service [SaaS] in the field of data centre optimisation; research, development, design and maintenance of computer software in the field of pharmaceutical research, biotechnology, bioinformatics and in silico design and testing; research, development, design and maintenance of computer software in the field of data centre optimisation; software as a service [SaaS] in the fields of optimisation and operations research; research, development, design and maintenance of computer software in the fields of optimisation and operations research; advisory and consulting services relating to the aforesaid; software as a service [SaaS] and platform as a services [PaaS] in the field of machine vision technology, artificial intelligence, deep learning, image analysis and inspection purpose; providing technical information and consulting in the field of data analytics, machine learning, or artificial intelligence; non-downloadable computer software incorporating artificial intelligence for collecting, analysing and organising data; non-downloadable artificial intelligence and machine learning software.

Goods & Services

Computer software and hardware; software in the field of artificial intelligence; machine learning software; augmented and virtual reality software; electronic tablets; smartphones; predictive analytics software; data analysis software; computer software in the field of pharmaceutical research, biotechnology, bioinformatics and in silico design and testing; data processing equipment; software for data centre optimisation; software in the fields of optimisation and operations research; downloadable computer software incorporating artificial intelligence for collecting, analysing and organising data; software for machine learning intelligent gateways for real-time data analysis; artificial intelligence software; artificial intelligence and machine learning software for machine vision devices. Software as a service [SaaS]; research and development of computer software; scientific research; technical research; design, installation, maintenance, updating and upgrading of computer software; software as a service [SaaS] in the field of artificial intelligence; troubleshooting of computer hardware and software problems; software customisation services; providing non-downloadable computer software; computer hardware design services; customised design of computer software; customised design of computer hardware; software as a service [SaaS] in the field of data centre optimisation; research, development, design and maintenance of computer software in the field of pharmaceutical research, biotechnology, bioinformatics and in silico design and testing; research, development, design and maintenance of computer software in the field of data centre optimisation; software as a service [SaaS] in the fields of optimisation and operations research; research, development, design and maintenance of computer software in the fields of optimisation and operations research; advisory and consulting services relating to the aforesaid; software as a service [SaaS] and platform as a service [PaaS] featuring software for use in machine vision technology, artificial intelligence, deep learning, image analysis and inspection; providing technical information and consulting in the field of data analytics, machine learning, or artificial intelligence; non-downloadable computer software incorporating artificial intelligence for collecting, analysing and organising data; non-downloadable artificial intelligence and machine learning software.

Abstract

A method of generating output data for manufacturing an electrical circuit is provided. A system and storage medium for implementing the method are also provided. The method includes obtaining input data representing an electrical circuit, and processing the input data to generate a first encoding for circuit elements and a second encoding for agents. An attention network, that implements two attention mechanisms, one for the first encoding and one for the second encoding, is provided. A process of selecting routing component characteristics is performed iteratively, using the attention network to determine routes for connecting circuit elements. Output data for manufacturing the electrical circuit is generated based on the selected routing component characteristics.

IPC Classes  ?

• G06F 30/323 - Translation or migration, e.g. logic to logic, hardware description language [HDL] translation or netlist translation
• G06F 30/394 - Routing

Abstract

Systems, storage mediums comprising instructions, and methods of training a neural network to determine solutions to an optimization problem are provided. The methods involve obtaining training data representing a plurality of instances of an optimization problem, each instance being represented by a set of state parameters. For each instance of the optimization problem, a plurality of solutions are generated, each solution being generated using a neural network conditioned on an N-dimensional vector. Training the neural network conditioned on an N-dimensional vector associated with the highest performing solution is performed. Systems, storage mediums, and methods of using an neural network trained to be conditioned on an N-dimensional vector are also provided. These methods involve a search process for identifying an N-dimensional vector selected from a vector latent space to obtain a solution for the instance of the optimization problem.

IPC Classes  ?

• G06N 3/092 - Reinforcement learning

Goods & Services

Downloadable computer software for use in manufacturing for data analysis, namely, downloadable or recorded data analysis software for reviewing, analyzing, tracking, updating, and organizing manufacturing data and computer hardware; downloadable computer software for use in the fields of agriculture, plant genomics, biological sequencing and identification of sequence-trait relationships; downloadable software in the field of artificial intelligence for use in database management, research, and manufacturing, namely, downloadable or recorded data analysis software for reviewing, analyzing, tracking, updating, and organizing data in the healthcare, pharmaceutical research, biotechnology, agriculture, plant genomics, biological sequencing, identification of sequence-trait relationships and silicon design fields; downloadable machine learning software for database management; downloadable machine learning software for use in research in the fields of agriculture, plant genomics, biological sequencing and identification of sequence-trait relationships; downloadable augmented and virtual reality software for reviewing, analyzing, tracking, updating, and organizing data in the healthcare, pharmaceutical research, biotechnology, agriculture, plant genomics, biological sequencing, identification of sequence-trait relationships and silicon design fields; electronic tablet computers; smartphones; downloadable predictive analytics software for database management; downloadable predictive analytics software for use in research relating to agriculture, plant genomics, biological sequencing and identification of sequence-trait relationships; downloadable data analysis software; downloadable computer software for database management in the field of pharmaceutical research, biotechnology, bioinformatics and in silico design and testing; data processing equipment; downloadable software for data centre optimisation; downloadable software in the fields of optimisation and operations research for database management, agriculture, plant genomics, biological sequencing and identification of sequence-trait relationships; downloadable computer software incorporating artificial intelligence for collecting, analysing and organising data; downloadable software for machine learning intelligent gateways for real-time data analysis; downloadable artificial intelligence software for database management and for research in the fields of agriculture, plant genomics, biological sequencing and identification of sequence-trait relationships; downloadable artificial intelligence and machine learning software for machine vision devices for database management and for research in the fields of agriculture, plant genomics, biological sequencing and identification of sequence-trait relationships Software as a service (SaaS) services featuring software using artificial intelligence for data analysis, machine learning, research in the field of agriculture, plant genomics, biological sequencing and identification of sequence-trait relationships, and manufacturing; research and development of computer software; scientific research ; technical research, namely in the field of artificial intelligence research; design, installation, maintenance, updating and upgrading of computer software; software as a service (SaaS) in the field of artificial intelligence featuring software for database management and featuring software for research in the fields of agriculture, plant genomics, biological sequencing and identification of sequence-trait relationships; troubleshooting of computer hardware and software problems; software customisation services; providing online non-downloadable computer software for database management and for research in the fields of agriculture, plant genomics, biological sequencing and identification of sequence-trait relationships; computer hardware design services; customised design of computer software; customised design of computer hardware; software as a service (SaaS) services featuring software for database management and for research in the fields of agriculture, plant genomics, biological sequencing and identification of sequence-trait relationships in the field of data centre optimisation; research, development, design and maintenance of computer software in the field of pharmaceutical research, biotechnology, bioinformatics and in silico design and testing; research, development, design and maintenance of computer software in the field of data centre optimisation; software as a service (SaaS) services featuring software for database management and for research in the fields of agriculture, plant genomics, biological sequencing and identification of sequence-trait relationships in the fields of optimisation and operations research; research, development, design and maintenance of computer software in the fields of optimisation and operations research; advisory and consulting services relating to the aforesaid; software as a service (SaaS) and platform as a service (PaaS) services featuring software for use in machine vision technology, artificial intelligence, deep learning, image analysis and inspection; providing technical technology information and consulting in the field of data analytics, machine learning, and artificial intelligence; providing online non-downloadable computer software incorporating artificial intelligence for collecting, analysing and organising data; providing online non-downloadable artificial intelligence and machine learning software for database management and for research in the fields of agriculture, plant genomics, biological sequencing and identification of sequence-trait relationships

Goods & Services

Computer software and hardware; software in the field of artificial intelligence; machine learning software; computer software for remote monitoring and analysis; computer software for the monitoring of computer systems; software for DNA testing; encoding and decoding apparatus; software for the analysis of human tissue, cells, proteins and genetics for medical purposes; software for monitoring, analysing, controlling and running physical world operations; software used for industrial monitoring and inspecting purposes; logistics software; inventory software; databases; computer software for application and database integration; augmented and virtual reality software; electronic tablets; smartphones; detectors; predictive analytics software; data analysis software; computer software in the field of manufacturing; workflow management software relating to routing and logistics optimisation; data processing equipment; software for data centre optimisation; software in the fields of optimisation and operations research, routing and logistics optimisation and bin packing; software for use in the field of supply chain; distance and dimension measuring instruments; three dimensional viewers; downloadable computer software for designing and modelling of three dimensional printable products; digital sensory devices; electric monitoring apparatus; electrical sensors; electronic monitoring instruments, other than for medical use; electronic sensors; electro-optical sensors; measuring, detecting, monitoring and controlling devices; microscopes; microscopes for industrial use; 3D computer graphics software; 3D animation software; handheld scanners; audio, visual and photographic devices; digital cameras; digital cameras for industrial use; digital optical transmission apparatus; digital sensors; monitoring apparatus and instruments; optical apparatus and instruments; optical communications instruments; optical devices, enhancers and correctors; optical inspection apparatus for industrial use; sensors [measurement apparatus], other than for medical use; optical measurement apparatus; optical character recognition apparatus; optical sensors; photographic apparatus and instruments; remote monitoring apparatus; testing and quality control devices; testing apparatus for diagnostic purposes [other than medical]; artificial intelligence and machine learning software; artificial intelligence software; interactive software based on artificial intelligence; humanoid robots with artificial intelligence for use in scientific research; computer software platforms to improve the efficiency and quality of scientific experiments and scientific research and product development; computer software platforms for monitoring and analysis experiments and research in the field of life sciences; computer software for controlling equipment for processing of cells; downloadable and recorded computer software for microscopy and imaging in the field of clinical, research, and diagnostic testing; interactive databases; software for the integration of artificial intelligence and machine learning in the field of big data; speech recognition software; speech analytics software; software converters of natural language into machine executable commands; downloadable computer chatbot software for simulating conversations; telepresence robots; downloadable pattern recognition software for identifying human faces; laboratory robots; teaching robots; user-programmable humanoid robots, not configured; downloadable computer programs and downloadable computer software for the artificial production of human speech and text; downloadable computer programs and downloadable computer software for natural language processing, generation, understanding and analysis; downloadable computer programs and downloadable computer software for machine-learning based language and speech processing software; voice recognition software; downloadable computer chatbot software for simulating conversations; downloadable computer programs and downloadable computer software for creating and generating text; downloadable electronic publications; downloadable electronic publications in the field of brochures, magazines, reports, articles, maps, diagrams relating to scientific experiments; parts and fittings for the aforesaid goods. Scientific research relating to genetics; analysis of human genetics, tissues, proteins and cells for medical research; DNA testing services; software as a service [SaaS]; research and development of computer software; scientific research; technical research; design, installation, maintenance, updating and upgrading of computer software; software as a service [SaaS] in the field of artificial intelligence; troubleshooting of computer hardware and software problems; software customisation services; providing non-downloadable computer software; computer hardware design services; software design; customised design of computer software; customised design of computer hardware; software as a service [SaaS] in the field of supply chain, routing and logistics optimisation; software as a service [SaaS] in the field of data centre optimisation; research, development, design and maintenance of computer software in the field of supply chain, routing and logistics optimisation and bin packing; research, development, design and maintenance of computer software in the field of data centre optimisation; software as a service [SaaS] in the fields of optimisation and operations research; research, development, design and maintenance of computer software in the fields of optimisation and operations research; platform as a service [PaaS] featuring software platforms for transmission of images, audio-visual content, video content and messages; design and development of computer software for reading, transmitting and organising data; design and development of software for inventory management; programming of computer software for reading, transmitting and organising data; progamming of software for inventory management; providing temporary use of on-line non-downloadable software for inventory management; rental of software for inventory management; development of computer software for logistics, supply chain management and e-business portals; analysis and testing services relating to monitoring and testing apparatus; computer system monitoring services; design of software for monitoring, analysing, controlling and running physical world operations; design of three dimensional displays; design of software for use with measuring, detecting, monitoring and controlling devices; design of software for use with surface inspection and monitoring devices; design of software used for industrial monitoring and inspecting purposes; monitoring of network systems; product quality testing; quality checking and testing; quality control services; testing, authentication and quality control; artificial intelligence consultancy; research in the field of artificial intelligence technology; programming of computer software for electronic language translation dictionaries and databases; research in the field of computer natural language processing; providing online non-downloadable software for the artificial production of human speech and text; providing online non-downloadable software for natural language processing, generation, understanding and analysis; providing online non-downloadable software for machine-learning based language and speech processing software; providing online non-downloadable chatbot software for simulating conversations; providing online non-downloadable software for creating and generating text; research and development services in the field of artificial intelligence; research, design and development of computer programs and software; encoding of the biological state of cells and tissues; technological research and consultancy relating to life sciences, laboratory support services, laboratory testing, laboratory analysis, pharmaceutical production, environmental testing, virology, bacteriology, bioprocess, cell and gene therapy, vaccine production; research in the field of artificial intelligence for use in the life sciences; product research and development in the field of life sciences and bioprocessing, and consultancy relating thereto; development of cloud based computer programs for simulating laboratory testing; product development services; platform as a service (PaaS), and cloud based services featuring software for customisation, optimisation, utilisation, modelling, and emulation relating to bioprocessing and bioprocess development; software as a service featuring software relating to manufacturing execution system (MES) in the field of pharmaceutical and biotechnology industries; design and laboratory development services for the creation of bioprocessing facilities and rooms therein for the life sciences industry; development of digital twins (research services); bioprocess engineering services and process development services; scientific and technological services relating to collecting, treating, analysing, storing, and preserving biological samples including collection and preservation of human blood, urine, saliva, sputum, human tissue, cellular material, and other biological material and biofluids originating from the human body and collected for use in laboratory testing and analysis, vaccine development, cell and gene therapy development, medical testing, analysis, and diagnosis, clinical testing, analysis, and diagnosis, industry and manufacture; testing services for the certification of quality and standards, and consultancy relating thereto; consultancy, advisory and information services relating to the aforesaid services. Medical services; providing medical information relating to pharmaceuticals, healthcare, medicines, vaccines, health conditions, health awareness and treatment options; medical information services, namely, providing information related to healthcare, diseases and disorders and treatment options; providing medial information relating to healthcare, health awareness, medicines, vaccines, diseases and disorders, and treatment options via a website; medical screening and testing services; medical analysis for the diagnosis of conditions and treatment of persons; behaviour analysis for medical purposes; monitoring of medical data for medical diagnosis and treatment; conducting of medical examination; alternative medical services; healthcare services provided via artificial intelligence; genetic testing for medical purposes; health assessment surveys; medical services provided via online computer software; performing diagnosis of diseases; providing medical support in the monitoring of patients receiving medical treatment; medical information services providing via the internet; information, advisory and consultancy services in relation to all the aforesaid.

Goods & Services

Computer software and hardware; software in the field of artificial intelligence; machine learning software; computer software for remote monitoring and analysis; computer software for the monitoring of computer systems; software for DNA testing; encoding and decoding apparatus; software for the analysis of human tissue, cells, proteins and genetics for medical purposes; software for monitoring, analysing, controlling and running physical world operations; software used for industrial monitoring and inspecting purposes; logistics software; inventory software; databases; computer software for application and database integration; augmented and virtual reality software; electronic tablets; smartphones; detectors; predictive analytics software; data analysis software; computer software in the field of manufacturing; workflow management software relating to routing and logistics optimisation; data processing equipment; software for data centre optimisation; software in the fields of optimisation and operations research, routing and logistics optimisation and bin packing; software for use in the field of supply chain; distance and dimension measuring instruments; three dimensional viewers; downloadable computer software for designing and modelling of three dimensional printable products; digital sensory devices; electric monitoring apparatus; electrical sensors; electronic monitoring instruments, other than for medical use; electronic sensors; electro-optical sensors; measuring, detecting, monitoring and controlling devices; microscopes; microscopes for industrial use; 3D computer graphics software; 3D animation software; handheld scanners; audio, visual and photographic devices; digital cameras; digital cameras for industrial use; digital optical transmission apparatus; digital sensors; monitoring apparatus and instruments; optical apparatus and instruments; optical communications instruments; optical devices, enhancers and correctors; optical inspection apparatus for industrial use; sensors [measurement apparatus], other than for medical use; optical measurement apparatus; optical character recognition apparatus; optical sensors; photographic apparatus and instruments; remote monitoring apparatus; testing and quality control devices; testing apparatus for diagnostic purposes [other than medical]; artificial intelligence and machine learning software; artificial intelligence software; interactive software based on artificial intelligence; humanoid robots with artificial intelligence for use in scientific research; computer software platforms to improve the efficiency and quality of scientific experiments and scientific research and product development; computer software platforms for monitoring and analysis experiments and research in the field of life sciences; computer software for controlling equipment for processing of cells; downloadable and recorded computer software for microscopy and imaging in the field of clinical, research, and diagnostic testing; interactive databases; software for the integration of artificial intelligence and machine learning in the field of big data; speech recognition software; speech analytics software; software converters of natural language into machine executable commands; downloadable computer chatbot software for simulating conversations; telepresence robots; downloadable pattern recognition software for identifying human faces; laboratory robots; teaching robots; user-programmable humanoid robots, not configured; downloadable computer programs and downloadable computer software for the artificial production of human speech and text; downloadable computer programs and downloadable computer software for natural language processing, generation, understanding and analysis; downloadable computer programs and downloadable computer software for machine-learning based language and speech processing software; voice recognition software; downloadable computer chatbot software for simulating conversations; downloadable computer programs and downloadable computer software for creating and generating text; downloadable electronic publications; downloadable electronic publications in the field of brochures, magazines, reports, articles, maps, diagrams relating to scientific experiments; parts and fittings for the aforesaid goods. Scientific research relating to genetics; analysis of human genetics, tissues, proteins and cells for medical research; DNA testing services; software as a service [SaaS]; research and development of computer software; scientific research; technical research; design, installation, maintenance, updating and upgrading of computer software; software as a service [SaaS] in the field of artificial intelligence; troubleshooting of computer hardware and software problems; software customisation services; providing non-downloadable computer software; computer hardware design services; software design; customised design of computer software; customised design of computer hardware; software as a service [SaaS] in the field of supply chain, routing and logistics optimisation; software as a service [SaaS] in the field of data centre optimisation; research, development, design and maintenance of computer software in the field of supply chain, routing and logistics optimisation and bin packing; research, development, design and maintenance of computer software in the field of data centre optimisation; software as a service [SaaS] in the fields of optimisation and operations research; research, development, design and maintenance of computer software in the fields of optimisation and operations research; platform as a service [PaaS] featuring software platforms for transmission of images, audio-visual content, video content and messages; design and development of computer software for reading, transmitting and organising data; design and development of software for inventory management; programming of computer software for reading, transmitting and organising data; progamming of software for inventory management; providing temporary use of on-line non-downloadable software for inventory management; rental of software for inventory management; development of computer software for logistics, supply chain management and e-business portals; analysis and testing services relating to monitoring and testing apparatus; computer system monitoring services; design of software for monitoring, analysing, controlling and running physical world operations; design of three dimensional displays; design of software for use with measuring, detecting, monitoring and controlling devices; design of software for use with surface inspection and monitoring devices; design of software used for industrial monitoring and inspecting purposes; monitoring of network systems; product quality testing; quality checking and testing; quality control services; testing, authentication and quality control; artificial intelligence consultancy; research in the field of artificial intelligence technology; programming of computer software for electronic language translation dictionaries and databases; research in the field of computer natural language processing; providing online non-downloadable software for the artificial production of human speech and text; providing online non-downloadable software for natural language processing, generation, understanding and analysis; providing online non-downloadable software for machine-learning based language and speech processing software; providing online non-downloadable chatbot software for simulating conversations; providing online non-downloadable software for creating and generating text; research and development services in the field of artificial intelligence; research, design and development of computer programs and software; encoding of the biological state of cells and tissues; technological research and consultancy relating to life sciences, laboratory support services, laboratory testing, laboratory analysis, pharmaceutical production, environmental testing, virology, bacteriology, bioprocess, cell and gene therapy, vaccine production; research in the field of artificial intelligence for use in the life sciences; product research and development in the field of life sciences and bioprocessing, and consultancy relating thereto; development of cloud based computer programs for simulating laboratory testing; product development services; platform as a service (PaaS), and cloud based services featuring software for customisation, optimisation, utilisation, modelling, and emulation relating to bioprocessing and bioprocess development; software as a service featuring software relating to manufacturing execution system (MES) in the field of pharmaceutical and biotechnology industries; design and laboratory development services for the creation of bioprocessing facilities and rooms therein for the life sciences industry; development of digital twins (research services); bioprocess engineering services and process development services; scientific and technological services relating to collecting, treating, analysing, storing, and preserving biological samples including collection and preservation of human blood, urine, saliva, sputum, human tissue, cellular material, and other biological material and biofluids originating from the human body and collected for use in laboratory testing and analysis, vaccine development, cell and gene therapy development, medical testing, analysis, and diagnosis, clinical testing, analysis, and diagnosis, industry and manufacture; testing services for the certification of quality and standards, and consultancy relating thereto; consultancy, advisory and information services relating to the aforesaid services. Medical services; providing medical information relating to pharmaceuticals, healthcare, medicines, vaccines, health conditions, health awareness and treatment options; medical information services, namely, providing information related to healthcare, diseases and disorders and treatment options; providing medial information relating to healthcare, health awareness, medicines, vaccines, diseases and disorders, and treatment options via a website; medical screening and testing services; medical analysis for the diagnosis of conditions and treatment of persons; behaviour analysis for medical purposes; monitoring of medical data for medical diagnosis and treatment; conducting of medical examination; alternative medical services; healthcare services provided via artificial intelligence; genetic testing for medical purposes; health assessment surveys; medical services provided via online computer software; performing diagnosis of diseases; providing medical support in the monitoring of patients receiving medical treatment; medical information services providing via the internet; information, advisory and consultancy services in relation to all the aforesaid.

Abstract

The present disclosure, among other things, provides technologies for identifying, characterizing, and/or monitoring variant sequences of a particular reference infections agent. Among other things, systems, methods, and architectures described herein provide visualization and decision support tools that can, e.g., facilitate decision making processes by local authorities and improve pandemic response in terms of, e.g., resource allocation, policy making, and speed tailored vaccine development. The present disclosure also provides tools for analyzing circulating variants to predict mutations likely to increase immune evasion of infectious agents.

IPC Classes  ?

• G16B 20/50 - Mutagenesis
• G16B 40/20 - Supervised data analysis
• G16B 45/00 - ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks
• G16B 50/30 - Data warehousingComputing architectures
• G16H 50/80 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for detecting, monitoring or modelling epidemics or pandemics, e.g. flu

Abstract

The present disclosure provides technologies for identifying, characterizing, and/or monitoring sequences of a variant of a reference infectious agent (e.g., but not limited to viral variants, for example in some embodiments SARS-CoV-2 variants) for transmissibility factors and/or immune escape potential, and/or for detecting and/or monitoring variants in environmental or biological samples, and/or for designing, preparing, and/or administering vaccines for such variants.

IPC Classes  ?

• G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
• C07K 14/005 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from viruses
• G16B 15/30 - Drug targeting using structural dataDocking or binding prediction
• G16B 40/20 - Supervised data analysis

Abstract

The present disclosure, among other things, provides technologies for identifying, characterizing, and/or monitoring variant sequences of a particular reference infections agent. Among other things, systems, methods, and architectures described herein provide visualization and decision support tools that can, e.g., facilitate decision making processes by local authorities and improve pandemic response in terms of, e.g., resource allocation, policy making, and speed tailored vaccine development. The present disclosure also provides tools for analyzing circulating variants to predict mutations likely to increase immune evasion of infectious agents.

IPC Classes  ?

• G16B 20/50 - Mutagenesis
• G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids

Abstract

The present disclosure, among other things, provides technologies for identifying, characterizing, and/or monitoring variant sequences of a particular reference infections agent. Among other things, systems, methods, and architectures described herein provide visualization and decision support tools that can. e.g., facilitate decision making processes by local authorities and improve pandemic response in terms of, e.g., resource allocation, policy making, and speed tailored vaccine development. The present disclosure also provides tools for analyzing circulating variants to predict mutations likely to increase immune evasion of infectious agents.

IPC Classes  ?

• G16B 20/50 - Mutagenesis
• G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids

Abstract

A method is provided for identifying a number of variants of concern of a reference disease associated immunogen. The method uses a language model to perform inference on data representing each of a plurality of variants and data representing the reference immunogen. For each of the plurality of variants and the reference immunogen, a characteristic vector is derived from an output feature map of a hidden layer of the language model. For each of the plurality of variants, a measure of distance is generated for the variant that includes calculating a measure of distance between the characteristic vector of the variant and the characteristic vector of the reference immunogen. A semantic change score is calculated for each variant based on the generated measure of distance for that variant. A variant of the reference immunogen is selected based, at least in part, on the generated the semantic change scores.

IPC Classes  ?

• G16B 15/30 - Drug targeting using structural dataDocking or binding prediction
• G06N 3/045 - Combinations of networks
• G06N 3/08 - Learning methods
• G06N 5/01 - Dynamic search techniquesHeuristicsDynamic treesBranch-and-bound
• G06N 20/00 - Machine learning
• G16B 40/20 - Supervised data analysis

Abstract

in-silicoin-silico design of custom, engineered, antigens. In particular, in certain embodiments, methods and system of the present disclosure provide for engineering antigens to reduce their activation of a memory immune response, such as B cell and/or T cell based response, when introduced into a subject. Designing antigens in this manner, may, for example, improve their performance as immunogenic compositions for purposes of vaccination. For example, without wishing to be bound to any particular theory, it is believed that, among other things, reducing the extent to which a memory immune response is triggered can lead to improved production of new antibodies that are selectively tailored by the subject's immune system to neutralize particular (e.g., arisen) epitopes of a reference antigen.

IPC Classes  ?

• G16B 20/00 - ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations

Goods & Services

Computer software and hardware, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; software in the field of artificial intelligence; machine learning software; augmented and virtual reality software, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; electronic tablets; smartphones; predictive analytics software; data analysis software, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; computer software in the field of pharmaceutical research, biotechnology, bioinformatics and in silico design and testing; data processing equipment, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; software for data centre optimisation; software in the fields of optimisation and operations research; films, exposed, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; downloadable films, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; recorded films, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; video films, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; podcasts, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; electronic publications, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; periodical publications, magazines, journals, books and diaries provided on-line from databases, from facilities provided on the Internet or from other networks (including websites), none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; periodical publications, journals, magazines and books downloadable in electronic form from the Internet, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; electronic publications in the field of science research, artificial intelligence and technology; publications in machine readable form and/or in electronically readable form, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; electronic publications, magazines, journals, texts, newsletters, information sheets, education and training material and learning modules, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting. Printed matter, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; magazines, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; newsletters, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; periodical publications, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; journals, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; books, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; printed publications, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; educational publications, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; publications relating to science and technology; pamphlets, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; leaflets none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; information letters none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; photographs none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; stationery; files; folders; writing implements [writing instruments]; instructional and teaching material none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; newspapers none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; printed manuals (handbooks) none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; diaries none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; calendars and wall charts. Marketing, advertising, and promotional services; retail services, online retail services and mail order services in relation to electronic publications (downloadable), printed matter, printed publications, newspapers, magazines, periodicals, stationery, calendars, diaries, books, newsletters, instructional and teaching materials; management advice; arranging and conducting exhibitions and trade shows; preparation of and compilation of statistics; retail services, online retail services relating to the sale of electronic publications (downloadable), printed matter, printed publications, newspapers, magazines, periodicals, stationery, calendars, diaries, books, newsletters, instructional and teaching materials; arranging to trading transactions and commercial contracts; retail services in relation to printed matter, printed publications, newspapers, magazines, periodicals, stationery, calendars, diaries, books, newsletters, instructional and teaching materials; none of the aforesaid services relating to TV and/or radio programmes and TV and/or radio broadcasting. Entertainment services; educational services; provision of training; arranging and conducting educational conferences, seminars, workshops and symposia; arranging and conducting exhibitions; production of films; providing on-line electronic publications; publication of texts, books, journals and of magazines; publication of electronic books and journals on-line; publishing from a computer database, from the Internet or from the world-wide web; providing publications on the Internet which may be browsed; providing electronic publications in the field of science research, artificial intelligence and technology; production and publication of texts, books, magazines, journals, printed matter, on-line information and educational resources in video, machine or computer readable, audio and/or word format; provision of information and consultancy and advisory services relating to the aforesaid services; none of the aforesaid services relating to TV and/or radio programmes and TV and/or radio broadcasting. Software as a service [SaaS]; research and development of computer software; scientific research; technical research; design, installation, maintenance, updating and upgrading of computer software; software as a service [SaaS] in the field of artificial intelligence; technical support services, namely, troubleshooting in the nature of diagnosing computer hardware and software problems; software customisation services; providing non-downloadable computer software, none of the aforesaid services relating to TV and/or radio programmes and TV and/or radio broadcasting; computer hardware design services; customised design of computer software; customised design of computer hardware; software as a service [SaaS] in the field of data centre optimisation; research, development, design and maintenance of computer software in the field of pharmaceutical research, biotechnology, bioinformatics and in silico design and testing; research, development, design and maintenance of computer software in the field of data centre optimisation; software as a service [SaaS] in the fields of optimisation and operations research; research, development, design and maintenance of computer software in the fields of optimisation and operations research; provision of scientific information for accessing via communication and computer networks and/or via the Internet; scientific research information provided in the form of websites; research relating to science, electronic publications, artificial intelligence and technology; advisory and consulting services relating to the aforesaid.

Goods & Services

Computer software and hardware, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; software in the field of artificial intelligence; machine learning software; augmented and virtual reality software, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; electronic tablets; smartphones; predictive analytics software; data analysis software, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; computer software in the field of pharmaceutical research, biotechnology, bioinformatics and in silico design and testing; data processing equipment, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; software for data centre optimisation; software in the fields of optimisation and operations research; films, exposed, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; downloadable films, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; recorded films, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; video films, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; podcasts, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; electronic publications, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; periodical publications, magazines, journals, books and diaries provided on-line from databases, from facilities provided on the Internet or from other networks (including websites), none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; periodical publications, journals, magazines and books downloadable in electronic form from the Internet, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; electronic publications in the field of science research, artificial intelligence and technology; publications in machine readable form and/or in electronically readable form, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; electronic publications, magazines, journals, texts, newsletters, information sheets, education and training material and learning modules, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting. Printed matter, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; magazines, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; newsletters, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; periodical publications, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; journals, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; books, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; printed publications, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; educational publications, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; publications relating to science and technology; pamphlets, none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; leaflets none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; information letters none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; photographs none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; stationery; files; folders; writing implements [writing instruments]; instructional and teaching material none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; newspapers none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; printed manuals (handbooks) none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; diaries none of the aforesaid goods relating to TV and/or radio programmes and TV and/or radio broadcasting; calendars and wall charts. Advertising, marketing and promotional services; retail services, online retail and mail order services in relation to electronic publications (downloadable), printed matter, printed publications, newspapers, magazines, periodicals, stationery, calendars, diaries, books, newsletters, instructional and teaching materials; arranging to trading transactions and commercial contracts; management advice; arranging and conducting exhibitions and trade shows; preparation of and compilation of statistics; retail services, online retail services relating to the sale of electronic publications (downloadable), printed matter, printed publications, newspapers, magazines, periodicals, stationery, calendars, diaries, books, newsletters, instructional and teaching materials; retail services relating to the sale of printed matter, printed publications, newspapers, magazines, periodicals, stationery, calendars, diaries, books, newsletters, instructional and teaching materials; none of the aforesaid services relating to TV and/or radio programmes and TV and/or radio broadcasting. Entertainment services; educational services; provision of training; arranging and conducting educational conferences, seminars, workshops and symposia; arranging and conducting exhibitions; production of films; providing on-line electronic publications; publication of texts, books, journals and of magazines; publication of electronic books and journals on-line; publishing from a computer database, from the Internet or from the world-wide web; providing publications on the Internet which may be browsed; providing electronic publications in the field of science research, artificial intelligence and technology; production and publication of texts, books, magazines, journals, printed matter, on-line information and educational resources in video, machine or computer readable, audio and/or word format; provision of information and consultancy and advisory services relating to the aforesaid services; none of the aforesaid services relating to TV and/or radio programmes and TV and/or radio broadcasting. Software as a service [SaaS]; research and development of computer software; scientific research; technical research; design, installation, maintenance, updating and upgrading of computer software; software as a service [SaaS] in the field of artificial intelligence; technical support services, namely, troubleshooting in the nature of diagnosing computer hardware and software problems; software customisation services; providing non-downloadable computer software, none of the aforesaid services relating to TV and/or radio programmes and TV and/or radio broadcasting; computer hardware design services; customised design of computer software; customised design of computer hardware; software as a service [SaaS] in the field of data centre optimisation; research, development, design and maintenance of computer software in the field of pharmaceutical research, biotechnology, bioinformatics and in silico design and testing; research, development, design and maintenance of computer software in the field of data centre optimisation; software as a service [SaaS] in the fields of optimisation and operations research; research, development, design and maintenance of computer software in the fields of optimisation and operations research; provision of scientific information for accessing via communication and computer networks and/or via the Internet; scientific research information provided in the form of websites; research relating to science, electronic publications, artificial intelligence and technology; advisory and consulting services relating to the aforesaid.

Goods & Services

Computer software and hardware; downloadable software applications; computer software platforms; machine learning software; software in the field of artificial intelligence; artificial intelligence software for analysis; interactive software based on artificial intelligence; humanoid robots with artificial intelligence for use in scientific research; software for integration of artificial intelligence and machine learning in the field of Big Data; software, namely, a high-performance distributed execution framework for large-scale machine learning and reinforcement learning applications; software featuring libraries for accelerating deep learning and reinforcement learning development; software for reproducing software applications and experiments; machine learning software; augmented and virtual reality software; decision making software; problem solving software; business software; digital solutions provider [DSP] software; predictive analytics software; data analysis software; intelligent gateways for real-time data analysis; computer software in the field of manufacturing; computer software used for the production and design of hardware; computer software used for the production and design of computer chips; automated workflow software; circuit boards; chips; downloadable electronic publications; downloadable electronic publications, namely books, magazines, journals, reports and research papers in the field of electronic solutions, software systems and artificial intelligence. Software as a service [SaaS]; platform as a service [PaaS]; application service provider [ASP] services; research services; research and development of computer software; research in the field of artificial intelligence technology; design, installation, maintenance and upgrading of computer software; software as a service [SaaS] in the field of artificial intelligence; providing artificial intelligence computer programs on data networks; platforms for artificial intelligence as software as a service [SaaS]; artificial intelligence consultancy; technology consultation in the field of artificial intelligence; technical data analysis services; computer programming services for the analysis of data; design of audio-visual creative works software as a service [SaaS} featuring computer software platforms for artificial intelligence; software as a service [SaaS] featuring software for machine learning; providing online non-downloadable software, namely, a high-performance distributed execution framework for large-scale machine learning and reinforcement learning applications; providing online non-downloadable software featuring libraries for accelerating deep learning and reinforcement learning development; providing online non-downloadable software for reproducing software applications and experiments; platform as a service [PaaS] featuring software platforms for transmission of images, audio-visual content, video content and messages; troubleshooting of computer hardware and software problems; software customisation services; providing non-downloadable computer software; computer hardware design services; computer chips design services; customised design of computer software; customised design of computer hardware; advisory and consulting services relating to the aforesaid.

Abstract

A computer-implemented method for evaluating an amino acid chain is provided. The method includes obtaining first data including a representation of an amino acid chain and performing a process to generate second data comprising a set of one or more probability values. The representation comprises a sequence of two or more letters, each letter representing a respective amino acid. The second process comprises, for a said position in the sequence of letters, applying a language models to the sequence of letters to determine at least one probability value associated with the said position, wherein the language model is trained using one or more datasets representing amino acid chains. A computer system configured to implement the method, and a non-transitory computer-readable storage medium, storing instructions for implementing the method, is also provided.

IPC Classes  ?

• G16B 30/00 - ICT specially adapted for sequence analysis involving nucleotides or amino acids
• G16B 40/30 - Unsupervised data analysis

Abstract

The present disclosure provides technologies for identifying, characterizing, and/or monitoring sequences of a variant of a reference infectious agent (e.g., but not limited to viral variants, for example in some embodiments SARS-CoV-2 variants) for transmissibility factors and/or immune escape potential, and/or for detecting and/or monitoring variants in environmental or biological samples, and/or for designing, preparing, and/or administering vaccines for such variants.

IPC Classes  ?

• G16B 15/30 - Drug targeting using structural dataDocking or binding prediction
• G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection

Abstract

A method is provided for identifying a number of variants of concern of a reference disease associated immunogen. The method uses a language model to perform inference on data representing each of a plurality of variants and data representing the reference immunogen. For each of the plurality of variants and the reference immunogen, a characteristic vector is derived from an output feature map of a hidden layer of the language model. For each of the plurality of variants, a measure of distance is generated for the variant that includes calculating a measure of distance between the characteristic vector of the variant and the characteristic vector of the reference immunogen. A semantic change score is calculated for each variant based on the generated measure of distance for that variant. A variant of the reference immunogen is selected based, at least in part, on the generated the semantic change scores.

IPC Classes  ?

• G16B 15/30 - Drug targeting using structural dataDocking or binding prediction
• G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
• G06N 20/00 - Machine learning
• G16B 40/20 - Supervised data analysis
• G16H 50/80 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for detecting, monitoring or modelling epidemics or pandemics, e.g. flu

Goods & Services

Downloadable computer software for use in manufacturing for data analysis, namely, downloadable or recorded data analysis software for reviewing, analyzing, tracking, updating, and organizing manufacturing data and computer hardware; downloadable software applications in the field of artificial intelligence for use in database management, research, and manufacturing, namely, downloadable or recorded data analysis software for reviewing, analyzing, tracking, updating, and organizing data in the healthcare, pharmaceutical research, biotechnology, and silicon design fields; downloadable computer software platforms for application development, web hosting, database management; downloadable machine learning software; downloadable software in the field of artificial intelligence for machine learning, software development and circuit board and computer chip design; downloadable artificial intelligence software for analysis of data; downloadable interactive software based on artificial intelligence for use in software development and machine learning; humanoid robots with artificial intelligence for use in scientific research; downloadable software for integration of artificial intelligence and machine learning in the field of big data; downloadable software, namely, a high-performance distributed execution framework for large-scale machine learning and reinforcement learning applications; downloadable software featuring libraries for accelerating deep learning and reinforcement learning development; downloadable software for reproducing software applications and experiments; downloadable augmented and virtual reality software for reviewing, analyzing, tracking, updating, and organizing data in the healthcare, pharmaceutical research, biotechnology, and silicon design fields; downloadable decision-making software; downloadable problem-solving software; downloadable business software for use in database management; downloadable digital solutions provider software for use in scientific research, namely artificial intelligence; downloadable predictive analytics software; downloadable data analysis software; intelligent gateway routers for real-time data analysis; downloadable computer software in the field of manufacturing for data analysis, namely, downloadable or recorded data analysis software for reviewing, analyzing, tracking, updating, and organizing manufacturing data; downloadable computer software used for the production and design of hardware; downloadable computer software used for the production and design of computer chips; downloadable automated workflow software; circuit boards; computer chips; downloadable electronic publications in the nature of journals, books, magazines, brochures, newsletters, information sheets, education and training material, and learning modules in the field of scientific research; downloadable electronic publications, namely, books, magazines, journals, reports, and research papers in the field of electronic solutions, software systems, and artificial intelligence Software as a service (SAAS) services featuring software using artificial intelligence for data analysis, machine learning, and manufacturing; platform as a service (PAAS) featuring computer software platforms for application development, web hosting, database management; application service provider (ASP) featuring software for use in database management in the field of scientific research; scientific research services in the field of computer software and the development of computer software for others; research and development of computer software; research in the field of artificial intelligence technology; design, installation, maintenance, and upgrading of computer software; software as a service (SAAS) services featuring software for troubleshooting of computer hardware problems, namely, computer hardware diagnosis in the field of artificial intelligence; providing online non-downloadable artificial intelligence computer programs on data networks for software development, machine learning, facial and speech recognition; platform as a service (PAAS) featuring computer software platforms for use in database management, in the fields of optimization and operations research for artificial intelligence as software as a service (SAAS); technology artificial intelligence consultancy; technology consultation in the field of artificial intelligence; technical data analysis services for others for design, installation, maintenance, updating, and upgrading of computer software; computer programming services for the analysis of data; design of audiovisual creative works software as a service (SAAS) featuring computer software platforms for artificial intelligence; software as a service (SAAS) services featuring software for machine learning; providing online non-downloadable software, namely, a high-performance distributed execution framework for large-scale machine learning and reinforcement learning applications; providing online non-downloadable software featuring libraries for accelerating deep learning and reinforcement learning development; providing online non-downloadable software for reproducing software applications and experiments; platform as a service (PAAS) featuring software platforms for transmission of images, audiovisual content, video content, and messages; technical support services, namely, troubleshooting in the nature of diagnosing computer hardware and software problems; software customization services; providing online non-downloadable computer software for use in conducting data analysis and database management in the healthcare, pharmaceutical research, biotechnology, and silicon design fields, and for use in editing, reviewing, analyzing, tracking, updating, and organizing data in the healthcare, pharmaceutical research, biotechnology, and silicon design fields; computer hardware design services; computer chips design services; customized design of computer software; customized design of computer hardware; advisory and consulting services relating to the aforesaid

Abstract

A computer-implemented method, a machine learning system, and non-transitory computer-readable storage medium for designing electrical circuits are provided. In the computer-implemented method input data is received and processed to generate a representation of the electrical circuit. A plurality of candidate routes for connecting a first and second circuit element of the electrical circuit are identified. A candidate route is then selected by iteratively selecting candidate sub-routes. Selecting candidate sub-routes is performed by using a Sequential Monte Carlo process to perform a look ahead search of a subset of the plurality of candidate routes, the Sequential Monte Carlo process being guided by a neural network. The representation of the electrical circuit is then updated with an action selection signal representing a selection of a candidate sub-route.

IPC Classes  ?

• G06F 30/394 - Routing
• G06F 30/3308 - Design verification, e.g. functional simulation or model checking using simulation
• G06F 30/3953 - Routing detailed
• G06F 30/398 - Design verification or optimisation, e.g. using design rule check [DRC], layout versus schematics [LVS] or finite element methods [FEM]
• G06N 3/04 - Architecture, e.g. interconnection topology
• G06N 3/047 - Probabilistic or stochastic networks
• G06N 3/08 - Learning methods
• G06N 20/00 - Machine learning
• G06F 111/08 - Probabilistic or stochastic CAD

Abstract

A computer-implemented method, a machine learning system, and non-transitory computer-readable storage medium for designing electrical circuits are provided. In the method input data, comprising an indication of a plurality of connections including a first and second connection is processed to generate a representation of the electrical circuit. Routes for the first and second connections are determined using an iterative process that includes defining one or more orders in which to determine routes for the first and second connections. A Sequential Monte Carlo process is used to perform a look ahead search of each defined order by generating simulations in respect of routes to be determined for the connections in the orders, the Sequential Monte Carlo process being guided by a neural network. A connection is selected and a route for the selected connection is determined. The representation is updated by providing an action selection signal representing the determined route.

IPC Classes  ?

• G06F 30/3953 - Routing detailed
• G06F 30/398 - Design verification or optimisation, e.g. using design rule check [DRC], layout versus schematics [LVS] or finite element methods [FEM]
• G06F 30/3308 - Design verification, e.g. functional simulation or model checking using simulation
• G06N 3/04 - Architecture, e.g. interconnection topology
• G06F 30/394 - Routing
• G06N 3/08 - Learning methods
• G06N 20/00 - Machine learning
• G06N 3/047 - Probabilistic or stochastic networks
• G06F 111/08 - Probabilistic or stochastic CAD

Abstract

A computer-implemented method, a system, and non-transitory computer-readable storage medium for designing electrical circuits are provided. In the method input data is received and processed to generate a representation of the electrical circuit. A first process is repeatedly performed to identify a plurality of candidate routes for connecting a first and second circuit element based on the representation. A candidate route is selected from the plurality of candidate routes based on a look ahead search. The first process includes selecting a first point in the representation, executing a second process to identify a set of candidate points, and selecting a second point from the set of candidate points. The second process comprises evaluating at least one candidate path extending in a linear direction from the first point to identify the set of candidate points based on at least a constraint and a topology of the electrical circuit.

IPC Classes  ?

• G06F 30/3953 - Routing detailed
• G06F 30/3308 - Design verification, e.g. functional simulation or model checking using simulation
• G06F 30/394 - Routing
• G06F 30/398 - Design verification or optimisation, e.g. using design rule check [DRC], layout versus schematics [LVS] or finite element methods [FEM]
• G06N 3/04 - Architecture, e.g. interconnection topology
• G06N 3/047 - Probabilistic or stochastic networks
• G06N 3/08 - Learning methods
• G06N 20/00 - Machine learning
• G06F 111/08 - Probabilistic or stochastic CAD

Abstract

A computer-implemented method, a machine learning system, and non-transitory computer-readable storage medium for training a neural network are provided. The neural network is used to instruct an agent to select actions for interacting with an environment to determine a solution to a specified problem. In the computer-implemented method a state signal representing a current state of the environment is received. A Sequential Monte Carlo process is then used to perform a search to determine target action selection data associated with the current state of the environment. This target action selection data is stored in association with the state signal and the current state of the environment is updated by providing an action selection signal based on the target action selection data. The Sequential Monte Carlo process involves generating a plurality of simulations using the neural network to determine the target action selection data.

IPC Classes  ?

• G06N 20/00 - Machine learning
• G06F 30/3308 - Design verification, e.g. functional simulation or model checking using simulation
• G06F 30/394 - Routing
• G06F 30/3953 - Routing detailed
• G06F 30/398 - Design verification or optimisation, e.g. using design rule check [DRC], layout versus schematics [LVS] or finite element methods [FEM]
• G06N 3/04 - Architecture, e.g. interconnection topology
• G06N 3/047 - Probabilistic or stochastic networks
• G06N 3/08 - Learning methods
• G06F 111/08 - Probabilistic or stochastic CAD

Abstract

A computer-implemented method (200), a machine learning system (100), and non- transitory computer-readable storage medium (400) for training a neural network (102) are provided. The neural network (102) is used to instruct an agent (106) to select actions for interacting with an environment (108) to determine a solution to a specified problem. In the computer-implemented method (200) a state signal (116) representing a current state of the environment (108) is received. A Sequential Monte Carlo process is then used to perform a search to determine target action selection data (306) associated with the current state of the environment (108). This target action selection data (306) is stored in association with the state signal (116) and the current state of the environment (108) is updated by providing an action selection signal (114) based on the target action selection data (306). The Sequential Monte Carlo process involves generating a plurality of simulations using the neural network (102) to determine the target action selection data (306).

IPC Classes  ?

• G06F 30/394 - Routing
• G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model
• G06F 111/08 - Probabilistic or stochastic CAD

Abstract

A computer-implemented method (600), a machine learning system (500), and non- transitory computer-readable storage medium (900) for designing electrical circuits are provided. In the computer-implemented method (600) input data (516) is received and processed to generate a representation (700) of the electrical circuit. A plurality of candidate routes (704a, 704b, 704c, 704d) for connecting a first (702a) and second (702j) circuit element of the electrical circuit are identified. A candidate route (704d) is then selected by iteratively selecting candidate sub-routes (706a, 706b, 706c, 706d). Selecting candidate sub-routes (706a, 706b, 706c, 706d) is performed by using a Sequential Monte Carlo process to perform a look ahead search of a subset of the plurality of candidate routes (704a, 704b, 704c, 704d), the Sequential Monte Carlo process being guided by a neural network (502). The representation (700) of the electrical circuit is then updated with an action selection signal (518) representing a selection of a candidate sub-route (704d).

IPC Classes  ?

• G06F 30/394 - Routing
• G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model
• G06F 111/08 - Probabilistic or stochastic CAD

Abstract

A computer-implemented method (1600), a machine learning system (1500), and non- transitory computer-readable storage medium (1900) for designing electrical circuits are provided. In the computer-implemented method (1600) input data (1516), comprising an indication of a plurality of connections including a first and second connection is received and processed to generate a representation (1700) of the electrical circuit. Routes for the first and second connections are determined using an iterative process. The iterative process includes defining one or more orders in which to determine routes for the first and second connections. A Sequential Monte Carlo process is then used to perform a look ahead search of each defined order by generating simulations in respect of routes to be determined for the connections in the orders, the Sequential Monte Carlo process being guided by a neural network (1502). A connection is selected and a route for the selected connection is determined. The representation (1700) is then updated by providing an action selection signal (1518) representing the determined route.

IPC Classes  ?

• G06F 30/394 - Routing
• G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model
• G06F 111/08 - Probabilistic or stochastic CAD

Abstract

A computer-implemented method (1100), a system (1000), and non-transitory computer-readable storage medium (1400) for designing electrical circuits are provided. In the computer-implemented method (1100) input data (1004) is received and processed to generate a representation (1200) of the electrical circuit. A first process (1110, 1112, 1114) is repeatedly performed to identify a plurality of candidate routes for connecting a first (1202a) and second (1202j) circuit element based on the representation (1200). A candidate route is selected from the plurality of candidate routes based on a look ahead search. The first process (1110, 1112, 1114) includes selecting a first point (1204a) in the representation, executing a second process (1116) to identify a set of candidate points (1204b, 1204c, 1204d), and selecting a second point (1204b) from the set of candidate points (1204b, 1204c, 1204d), whereby to identify comprising the selected first (1204a) and second (1204b) points. The second process (1116) comprises evaluating at least one candidate path (1206) extending in a linear direction from the first point (1204a) to identify the set of candidate points (1204b, 1204c, 1204d) based on at least a constraint and a topology of the electrical circuit.

IPC Classes  ?

• G06F 30/394 - Routing
• G06F 30/27 - Design optimisation, verification or simulation using machine learning, e.g. artificial intelligence, neural networks, support vector machines [SVM] or training a model
• G06F 111/08 - Probabilistic or stochastic CAD

Goods & Services

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Goods & Services

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Goods & Services

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Goods & Services

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Goods & Services

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Goods & Services

Computer software and hardware; software in the field of artificial intelligence; machine learning software; augmented and virtual reality software; predictive analytics software; data analysis software; computer software in the field of manufacturing; computer software used for the production and design of hardware; computer software used for the production and design of computer chips; automated workflow software; circuit boards; chips; software for use in the field of supply chain, routing and logistics optimisation; software for data centre optimisation; software in the fields of optimisation and operations research. Software as a service [SaaS]; research and development of computer software; design, installation, maintenance and upgrading of computer software; software as a service [SaaS] in the field of artificial intelligence; troubleshooting of computer hardware problems, namely, computer hardware diagnosis; troubleshooting of computer software problems; software customisation services; providing non-downloadable computer software; computer hardware design services; computer chips design services; customised design of computer software; customised design of computer hardware; software as a service [SaaS] in the field of supply chain, routing and logistics optimisation; software as a service [SaaS] in the field of data centre optimisation; research, development, design and maintenance of computer software in the field of supply chain, routing and logistics optimisation; research, development, design and maintenance of computer software in the field of data centre optimisation; software as a service [SaaS] in the fields of optimisation and operations research; research, development, design and maintenance of computer software in the fields of optimisation and operations research; advisory and consulting services relating to the aforesaid; provision of data centre facilities.

Goods & Services

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Goods & Services

Computer software and hardware; software in the field of artificial intelligence; machine learning software; augmented and virtual reality software; predictive analytics software; data analysis software; computer software in the field of manufacturing; computer software used for the production and design of hardware; computer software used for the production and design of computer chips; automated workflow software; circuit boards; chips. Software as a service [SaaS]; research and development of computer software; design, installation, maintenance and upgrading of computer software; software as a service [SaaS] in the field of artificial intelligence; troubleshooting of computer hardware and software problems; software customisation services; providing non-downloadable computer software; computer hardware design services; computer chips design services; customised design of computer software; customised design of computer hardware; advisory and consulting services relating to the aforesaid.

Goods & Services

Computer software and hardware; software in the field of artificial intelligence; machine learning software; augmented and virtual reality software; predictive analytics software; data analysis software; computer software in the field of manufacturing; computer software used for the production and design of hardware; computer software used for the production and design of computer chips; automated workflow software; circuit boards; chips. Software as a service [SaaS]; research and development of computer software; design, installation, maintenance and upgrading of computer software; software as a service [SaaS] in the field of artificial intelligence; troubleshooting of computer hardware and software problems; software customisation services; providing non-downloadable computer software; computer hardware design services; computer chips design services; customised design of computer software; customised design of computer hardware; advisory and consulting services relating to the aforesaid.

Goods & Services

Computer software and hardware; software in the field of artificial intelligence; machine learning software; augmented and virtual reality software; predictive analytics software; data analysis software; computer software in the field of manufacturing; computer software used for the production and design of hardware; computer software used for the production and design of computer chips; automated workflow software; circuit boards; chips. Software as a service [SaaS]; research and development of computer software; design, installation, maintenance and upgrading of computer software; software as a service [SaaS] in the field of artificial intelligence; troubleshooting of computer hardware and software problems; software customisation services; providing non-downloadable computer software; computer hardware design services; computer chips design services; customised design of computer software; customised design of computer hardware; advisory and consulting services relating to the aforesaid.

Goods & Services

Downloadable computer software for machine learning, software development and integrated circuit and computer chip design, and computer hardware; downloadable software using artificial intelligence for machine learning, software development and integrated circuit and computer chip design; downloadable machine learning software; downloadable augmented and virtual reality software for designing and producing integrated circuits and computer chips; downloadable predictive analytics software; downloadable data analysis software; downloadable computer software in the field of manufacturing for manufacturing integrated circuits and computer chips; downloadable computer software used for the production and design of hardware; downloadable computer software used for the production and design of computer chips; downloadable automated workflow software; circuit boards; computer chips, multiprocessor chips : Software as a service (SaaS) services featuring software for machine learning, software development and integrated circuit and computer chip design; research and development of computer software; design, installation, maintenance and upgrading of computer software; software as a service (SaaS) services featuring software using artificial intelligence for machine learning, software development and integrated circuit and computer chip design; technical support services, namely, troubleshooting in the nature of diagnosing of computer hardware and software problems; customising computer software; providing temporary use of online non-downloadable computer software for machine learning, software development and integrated circuit and computer chip design; computer hardware design services; computer chips design services; customised design of computer software; customised design of computer hardware; advisory and consulting services relating to the aforesaid

Goods & Services

Downloadable computer software for machine learning, software development and integrated circuit and computer chip design, and computer hardware; downloadable software using artificial intelligence for machine learning, software development and integrated circuit and computer chip design; downloadable machine learning software; downloadable augmented and virtual reality software for designing and producing integrated circuits and computer chips; downloadable predictive analytics software; downloadable data analysis software; downloadable computer software in the field of manufacturing for manufacturing integrated circuits and computer chips; downloadable computer software used for the production and design of hardware; downloadable computer software used for the production and design of computer chips; downloadable automated workflow software; circuit boards; computer chips, multiprocessor chips Software as a service (SaaS) services featuring software for machine learning, software development and integrated circuit and computer chip design; research and development of computer software; design, installation, maintenance and upgrading of computer software; software as a service (SaaS) services featuring software using artificial intelligence for machine learning, software development and integrated circuit and computer chip design; technical support services, namely, troubleshooting in the nature of diagnosing of computer hardware and software problems; customising computer software; providing temporary use of online non-downloadable computer software for machine learning, software development and integrated circuit and computer chip design; computer hardware design services; computer chips design services; customised design of computer software; customised design of computer hardware; advisory and consulting services relating to the aforesaid

Goods & Services

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Goods & Services

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Goods & Services

Software in the fields of artificial intelligence, deep learning, augmented and virtual reality. Software as a service in the fields of artificial intelligence, augmented and virtual reality.