Compounds of Formula I or II, methods of preparation and of use thereof. Formula I has a core aromatic group with substituents as follows: Formula (I) wherein G1 is —(CH2)nC(R1)(R2)OH, —(CH2)n; —CHO, —(CH2)nC(O)NR1R2, —(CH2)nCH (R1)NR1R2, —(CH2)nC(O)OR3, —(CH2)n—CH(R1)O—R3, or —(CH2)nC(O)R3; G2 and G4 are independently H, OH, F, or Cl, where G2 can also be NH2; G3 and G5 are independently (H, F, Cl, OH, —(CH2)n-optionally substituted heterocycle, —(CH2)n-optionally substituted phenyl, —(CH2)nC3H5, optionally substituted C1-C6 alkyl, optionally substituted C2-C6 alkenyl, —C(O)—R3, or CH(OH)—R3; and G6 is H, F, Cl, OH, —(CH2)n-optionally substituted heterocycle, —(CH2)n-optionally substituted phenyl, or (CH2)nCOOH, wherein ⋅n is an integer selected from 0 to 5, ⋅R1 and R2 are independently selected from H and optionally substituted C1-C6 alkyl group, and ⋅R3 is an optionally substituted C1-C6 alkyl group or when present on G1 forms a lactone with the core aromatic group, or a pharmaceutically acceptable salt thereof.
Compounds of Formula I or II, methods of preparation and of use thereof. Formula I has a core aromatic group with substituents as follows: Formula (I) wherein G1 is —(CH2)nC(R1)(R2)OH, —(CH2)n; —CHO, —(CH2)nC(O)NR1R2, —(CH2)nCH (R1)NR1R2, —(CH2)nC(O)OR3, —(CH2)n—CH(R1)O—R3, or —(CH2)nC(O)R3; G2 and G4 are independently H, OH, F, or Cl, where G2 can also be NH2; G3 and G5 are independently (H, F, Cl, OH, —(CH2)n-optionally substituted heterocycle, —(CH2)n-optionally substituted phenyl, —(CH2)nC3H5, optionally substituted C1-C6 alkyl, optionally substituted C2-C6 alkenyl, —C(O)—R3, or CH(OH)—R3; and G6 is H, F, Cl, OH, —(CH2)n-optionally substituted heterocycle, —(CH2)n-optionally substituted phenyl, or (CH2)nCOOH, wherein ⋅n is an integer selected from 0 to 5, ⋅R1 and R2 are independently selected from H and optionally substituted C1-C6 alkyl group, and ⋅R3 is an optionally substituted C1-C6 alkyl group or when present on G1 forms a lactone with the core aromatic group, or a pharmaceutically acceptable salt thereof.
C07C 235/34 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
C07C 39/11 - Alkylated hydroxy benzenes containing also acyclically bound hydroxy groups, e.g. saligenol
C07C 215/68 - Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
C07C 33/20 - Monohydroxylic alcohols containing only six-membered aromatic rings as cyclic part monocyclic
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
Compounds of Formula I or II, methods of preparation and of use thereof. Formula I has a core aromatic group with substituents as follows: Formula (I) wherein G1 is -(CH2)nC(R1)(R2)OH, -(CH2)n-CHO, -(CH2)nC(O)NR1R2, -(CH2)nCH (R1)NR1R2, -(CH2)nC(O)OR3, -(CH2)n-CH(R1)O-R3, or -(CH2)nC(O)R3; G2 and G4 are independently H, OH, F, or Cl, where G2 can also be NH2; G3 and G5 are independently H, F, Cl, OH, -(CH2)n-optionally substituted heterocycle,-(CH2)n-optionally substituted phenyl, -(CH2)nC3H5, optionally substituted C1-C6 alkyl, optionally substituted C2-C6 alkenyl, -C(O)-R3, or CH(OH)-R3; and G6 is H, F, Cl, OH, -(CH2)n-optionally substituted heterocycle, -(CH2)n-optionally substituted phenyl, or (CH2)nCOOH, wherein ? n is an integer selected from 0 to 5, ? R1 and R2 are independently selected from H and optionally substituted C1-C6 alkyl group, and ? R3 is an optionally substituted C1-C6 alkyl group or when present on G1 forms a lactone with the core aromatic group, or a pharmaceutically acceptable salt thereof.
A61K 31/216 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
C07C 39/11 - Alkylated hydroxy benzenes containing also acyclically bound hydroxy groups, e.g. saligenol
C07C 43/178 - Unsaturated ethers containing hydroxy or O-metal groups
C07C 47/27 - Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
C07C 49/245 - Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
C07C 69/732 - Esters of carboxylic acids having esterified carboxyl groups bound to acyclic carbon atoms and having any of the groups OH, O-metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
C07C 215/68 - Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
C07C 235/34 - Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Pharmaceutical research and development; research on the subject of pharmaceuticals; development of pharmaceutical preparations and medicines; pharmaceutical evaluation services; providing medical and scientific research information in the field of pharmaceuticals and clinical trials;
