Surfboards; Archery implements; Artificial fishing bait; Bags especially designed for skis and surfboards; Bite sensors; Bows for archery; Fish hooks; Fishing creels; Fishing lines; Fishing rod cases; Fishing sinkers; Fishing tackle; Fishing tackle boxes; Floats for fishing; Landing nets for anglers; Reels for fishing; Rods for fishing; Surf skis; Toys for domestic pets
Surfboards; Archery implements; Artificial fishing bait; Bags especially designed for skis and surfboards; Bite sensors; Bows for archery; Fish hooks; Fishing creels; Fishing lines; Fishing rod cases; Fishing sinkers; Fishing tackle; Fishing tackle boxes; Floats for fishing; Landing nets for anglers; Reels for fishing; Rods for fishing; Surf skis; Toys for domestic pets
Disclosed are promoieties of the following formula which can be used to form prodrugs of nitrogen-containing or hydroxyl-containing drug or a pharmaceutically active agent:
Disclosed are promoieties of the following formula which can be used to form prodrugs of nitrogen-containing or hydroxyl-containing drug or a pharmaceutically active agent:
Disclosed are promoieties of the following formula which can be used to form prodrugs of nitrogen-containing or hydroxyl-containing drug or a pharmaceutically active agent:
and pharmaceutical compositions comprising the prodrugs.
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
A61K 47/60 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
Gloves; Hats; Headscarves; Ponchos; Shawls; Trousers; Face masks being headwear; Sport stockings; Suspenders for clothing; Water repelling footwear; Water repelling leather shoes and boots; Waterproof jackets and pants
The present invention relates to the field of biopharmaceuticals, and in particular to a protein, a protein conjugate, a pharmaceutical composition and its use for treating diabetes. The fusion protein of the present invention is obtained by linking two polypeptides, wherein one polypeptide is an interleukin-1 receptor antagonistic protein or an analogue thereof, and another polypeptide is GLP-1 receptor binding polypeptide or an analogue thereof, or an insulin receptor binding polypeptide or an analogue thereof, or a GIP receptor binding polypeptide or an analogue thereof. The fusion proteins of the present invention and conjugates thereof have a significant efficacy in treating diabetes, and can be used in a lower dose, resulting in marked reduction in side effects.
Disclosed are promoieties of the following formula which can be used to form prodrugs of nitrogen-containing or hydroxyl-containing drug or a pharmaceutically active agent: (I) and pharmaceutical compositions comprising the prodrugs.
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
An automatic-control fluid jet guide lift pump comprises a fluid jet guide device (1) and a delivery pump (2). On the delivery pump (2) is installed a liquid lever sensor (3). The delivery pump (2) is provided with a gas outlet (4) on its upper part, which is connected in a gastight manner with the fluid jet guide device (1) via a gas suction pipe (9).
