Abstract

This composite material has a first structure or a second structure including a carbon material, particles containing iron group elements, and compounds containing alkali metal elements (alkali metal and/or alkaline earth metal). In the first structure, a large number of particles containing iron group elements and compounds containing alkali metal elements are dispersed in the carbon skeleton of the carbon material, the particles containing iron group elements contain iron group metal particles having a passivated particle surface, and the compounds containing alkali metal elements are present at least as oxides containing alkali metal elements and/or carbonates containing alkali metal elements. In the second structure, a large number of particles containing iron group elements are dispersed in the carbon skeleton of the carbon material, a large number of compounds containing alkali metal elements are collectively present on the surface of the particles containing iron group elements, the particles containing iron group elements contain iron group metal particles, and the compounds containing alkali metal elements are present at least as oxides containing alkali metal elements.

IPC Classes  ?

• B01J 23/78 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group of the iron group metals or copper combined with metals, oxides or hydroxides provided for in groups with alkali- or alkaline earth metals or beryllium
• B01J 27/232 - Carbonates
• B01J 37/08 - Heat treatment
• B01J 37/18 - Reducing with gases containing free hydrogen
• C01C 1/04 - Preparation of ammonia by synthesis

Abstract

This power storage device is provided with: a container that is filled with an electrolyte solution; metal atoms that are ionized in the electrolyte solution and are involved in charging and discharging; and an electrode that is disposed in the electrolyte solution. This power storage device is configured such that a layer of the metal atoms, in which the metal atoms are deposited, is formed on the surface of the electrode during charging. A storage method for the power storage device includes: a step of charging the power storage device; and a step of maintaining the temperature of the power storage device at a predetermined storage temperature of 25°C to 65°C inclusive by setting the power storage device after charging in an open circuit state.

IPC Classes  ?

• H01M 10/42 - Methods or arrangements for servicing or maintenance of secondary cells or secondary half-cells
• H01G 11/14 - Arrangements or processes for adjusting or protecting hybrid or EDL capacitors
• H01M 4/66 - Selection of materials
• H01M 4/70 - Carriers or collectors characterised by shape or form
• H01M 10/0566 - Liquid materials
• H01M 10/058 - Construction or manufacture
• H01M 10/48 - Accumulators combined with arrangements for measuring, testing or indicating the condition of cells, e.g. the level or density of the electrolyte

Abstract

The present disclosure provides a method for treating angiogenesis in a target tissue in a subject. According to the present disclosure, there is provided a method which includes administering an immunogenic composition containing messenger RNA (mRNA) that encodes LRG1 or a fragment thereof to the subject.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• A61K 9/51 - Nanocapsules
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• A61K 47/28 - Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
• A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
• A61P 27/02 - Ophthalmic agents
• A61P 35/00 - Antineoplastic agents
• A61P 37/04 - Immunostimulants
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

General formula (1): [In the formula, A1are the same or different and represent an adamantane ring. R1and R2 are the same or different and represent a hydrogen atom, a halogen atom, an alkyl group, a cycloalkyl group, an aryl group, a cyano group, a carbamoyl group, an amino group, a silyl group, or an adamantyl group. n represents an integer from 2 to 8.] This adamantane-fused oligothiophene compound represented by the formula is an oligothiophene compound in which the thiophene ring takes an s-cis conformation, and can be easily synthesized.

IPC Classes  ?

• C07D 495/14 - Ortho-condensed systems
• C07D 495/04 - Ortho-condensed systems

Abstract

A lead screw unit according to the present disclosure comprises a shaft part that extends along the axial direction, a first holder part that rotatably holds one end of the shaft part, a second holder part that rotatably holds the other end of the shaft part, a first support part that supports the first holder part, and a second support part that supports the second holder part. A nut is provided with a cutout part penetrating in the axial direction. The width of the first support part and/or the second support part is smaller than the width of the cutout part of the nut.

IPC Classes  ?

• F16H 25/24 - Elements essential to such mechanisms, e.g. screws, nuts
• F16H 25/20 - Screw mechanisms
• H01F 7/02 - Permanent magnets
• H02K 7/06 - Means for converting reciprocating motion into rotary motion or vice versa

Abstract

In a field effect transistor 1, a plurality of unit transistors are lined up in one direction d1, each of the unit transistors having a source electrode S, a drain electrode D, and a gate electrode 4. A gate wire 10 extends in the one direction d1 and connects the plurality of gate electrodes 4 to one another. A signal input electrode G1 is connected to the gate wire 10. At least one impedance element 18a is connected between the gate wire 10 and the signal input electrode G1. The position at which the impedance element 18a connects to the gate wire 10 is located on one end side of the gate wire 10 in the one direction d1 with respect to the signal input electrode G1.

IPC Classes  ?

• H10D 30/87 - FETs having Schottky gate electrodes, e.g. metal-semiconductor FETs [MESFET]
• H10D 30/47 - FETs having zero-dimensional [0D], one-dimensional [1D] or two-dimensional [2D] charge carrier gas channels having 2D charge carrier gas channels, e.g. nanoribbon FETs or high electron mobility transistors [HEMT]
• H10D 30/60 - Insulated-gate field-effect transistors [IGFET]

Abstract

A power storage device 10 includes: an electrolyte 12 containing a lithium imide salt and an organic solvent; a container 11 filled with the electrolyte 12; a positive electrode 30 which includes a compound containing lithium atoms that are ionized in the electrolyte 12 and that are involved in charge and discharge; a negative electrode 20 which is arranged in the electrolyte, includes a metal substrate 23 constituting a collector 21, and is configured so that a layer where the lithium atoms are deposited is formed on the surface of the negative electrode during charging; and a separator 15 which has electric insulation properties, divides the inside of the container 11 into a first electrode chamber 16 where the negative electrode is disposed and a second electrode chamber 17 where the positive electrode 30 is disposed, and transmits lithium ions moving between the first electrode chamber 16 and the second electrode chamber 17.

IPC Classes  ?

• H01M 10/052 - Li-accumulators
• H01M 4/133 - Electrodes based on carbonaceous material, e.g. graphite-intercalation compounds or CFx
• H01M 4/70 - Carriers or collectors characterised by shape or form
• H01M 10/0567 - Liquid materials characterised by the additives
• H01M 10/0568 - Liquid materials characterised by the solutes
• H01M 10/0569 - Liquid materials characterised by the solvents

Abstract

A magnetic power transmission structure according to the present disclosure comprises a shaft member extending along the axial direction, a cylindrical unit having a hollow section penetrating in the axial direction, and one or more first magnets magnetized in the axial direction. A ridge formed around the axis is provided to the outer peripheral surface of the shaft member. The cylindrical unit includes a first protrusion formation part and a second protrusion formation part. A protrusion is provided to the inner peripheral surface of each protrusion formation part so as to face the ridge of the shaft member. The second protrusion formation part is disposed adjacent to the first protrusion formation part in the axial direction. The one or more first magnets are disposed between the first protrusion formation part and the second protrusion formation part in the axial direction.

IPC Classes  ?

• F16H 49/00 - Other gearing
• F16H 25/24 - Elements essential to such mechanisms, e.g. screws, nuts

Abstract

The present invention provides an inhibitor capable of inhibiting the expression of PCDHA11 and inhibiting the function of PCDHA11. Specifically, the present invention provides nucleic acid molecules such as siRNA or antisense nucleic acids that inhibit PCDHA11 expression. These inhibitors are effective against gastric cancer, pancreatic cancer, breast cancer, esophageal squamous cell carcinoma, lung adenocarcinoma, colon cancer, and the like, and can be used as pan-cancer therapeutics.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61P 35/00 - Antineoplastic agents
• A61P 35/04 - Antineoplastic agents specific for metastasis
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• C12Q 1/686 - Polymerase chain reaction [PCR]
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

ISISS, a metal element necessarily including at least one of Ag, Au, and Al. The hydrogen-permeable membrane according to the present invention has improved hydrogen permeability in a low-temperature region of 200℃ or lower. Specifically, in the hydrogen-permeable membrane, the ratio (φ100/φ300) between the hydrogen permeation coefficient φ100at 100°C and the hydrogen permeation coefficient φ300 at 300°C is 0.4 or greater.

IPC Classes  ?

• C22C 5/04 - Alloys based on a platinum group metal
• C22F 1/00 - Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working
• C22F 1/14 - Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of noble metals or alloys based thereon

Abstract

A microscope image display device 1 comprises: an original image acquisition unit 11 that acquires an original image from a microscope; an interest object inference unit 12 that uses machine learning to infer an object of interest from the original image; an inference result evaluation unit 13 that evaluates reliability of the inference result of the inferred object of interest; and a display unit 14 that displays the position of the inferred object of interest on the original image in a state of being superimposed on the original image in a manner of displaying according to the reliability of the inference result.

IPC Classes  ?

• G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes
• A61B 1/045 - Control thereof
• G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers
• G01N 33/483 - Physical analysis of biological material
• G06T 7/00 - Image analysis
• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
• H04N 7/18 - Closed-circuit television [CCTV] systems, i.e. systems in which the video signal is not broadcast

Abstract

This composite ceramic comprises: a matrix phase that contains a first ceramic in which the average value of linear transmittance in the wavelength range of 1.5-3.3 µm is 80% or more as measured by a Fourier transform infrared spectrophotometer; and a dispersion phase that contains a second ceramic in which the average value of linear transmittance in the wavelength range of 1.5-3.3 µm is less than 20% as measured by a Fourier transform infrared spectrophotometer.

IPC Classes  ?

• C04B 35/16 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on silicates other than clay
• C04B 35/622 - Forming processesProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products
• C04B 38/00 - Porous mortars, concrete, artificial stone or ceramic warePreparation thereof
• F28D 20/00 - Heat storage plants or apparatus in generalRegenerative heat-exchange apparatus not covered by groups or

Abstract

Provided is a compound that exhibits a circadian rhythm regulating action by transmucosal intake, particularly oral intake. Also provided is a transmucosal intake agent comprising at least one selected from the group consisting of a compound represented by general formula (1), a salt thereof, and solvates of the same.

IPC Classes  ?

• A61K 31/4162 - 1,2-Diazoles condensed with heterocyclic ring systems
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
• A61K 9/10 - DispersionsEmulsions
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 9/20 - Pills, lozenges or tablets
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61P 3/08 - Drugs for disorders of the metabolism for glucose homeostasis
• A61P 25/20 - HypnoticsSedatives
• C07D 495/04 - Ortho-condensed systems

Abstract

As a natural killer cell line having improved proliferation capability and improved cytotoxic activity, a natural killer cell line in which the expression of CUL5 gene is reduced is provided.

IPC Classes  ?

• C12N 5/16 - Animal cells
• C07K 19/00 - Hybrid peptides
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells

Abstract

[Problem] To provide a gas separation device that separates a prescribed gas from a mixed gas more accurately and at lower cost. [Solution] A gas separation device 1 comprises a first electrode 20, a second electrode 22, and an AC voltage application unit 24 that applies an AC voltage between the first electrode 20 and the second electrode 22. The first electrode 20 and the second electrode 22 are disposed so as to have parts that are not parallel to each other. A distance T, which is the minimum distance among the distances between the first electrode 20 and the second electrode 22, is 1-100,000 nm. The product obtained by multiplying the pressure p of a mixed gas that is introduced between the first electrode 20 and the second electrode 22 and the distance T, which is the minimum distance among the distances between the first electrode 20 and the second electrode 22, is on the lower side of a Paschen curve. In addition, the product obtained by multiplying the pressure p and a distance U, which is the maximum distance among the inter-electrode distances, is on the lower side of the Paschen curve.

IPC Classes  ?

• B03C 9/00 - Electrostatic separation not provided for in any single one of the other main groups of this subclass

Abstract

An object is to provide an amidite monomer of diaminopurine and/or an amidite monomer of a thiouracil derivative suitable for use in synthesis of an acyclic single-stranded polynucleotide comprising diaminopurine and/or a thiouracil derivative by a phosphoramidite method. This object is achieved by an amidite monomer of diaminopurine and/or an amidite monomer of a thiouracil derivative protected with a specific protecting group removable by a base.

IPC Classes  ?

• C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
• C07F 9/6512 - Six-membered rings having the nitrogen atoms in positions 1 and 3
• C07F 9/6561 - Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
• C07H 1/00 - Processes for the preparation of sugar derivatives

Abstract

Provided is an etching device capable of forming, with high throughput, a plurality of through holes in an insulating substrate. This etching device (1) forms a plurality of through holes in an insulating substrate (W). The etching device (1) is provided with a chamber (2), a mask (3), a bias application unit (4), and a plasma generation unit (5). The insulating substrate (W) is carried into the chamber (2). The mask (3) has a plurality of first openings (3a) and faces the insulating substrate (W). The bias application unit (4) applies a negative voltage to the mask (3). The plasma generation unit (5) generates plasma and supplies cations in the plasma to the insulating substrate (W) through the plurality of first openings (31a) of the mask (3).

IPC Classes  ?

• C03C 15/00 - Surface treatment of glass, not in the form of fibres or filaments, by etching
• H05H 1/46 - Generating plasma using applied electromagnetic fields, e.g. high frequency or microwave energy

Abstract

A magnetic sensor (1A) comprises an electroconductive excitation body (21) through which an intermittent current is supplied, a magnetic body (22) that is provided on the surface of the excitation body (21) and has lower electroconductivity than the excitation body (21), a coil (3) wound around the excitation body (21) and the magnetic body (22), and a detection unit (9) for detecting an external magnetic field by detecting a voltage generated in the coil 3 by the external magnetic field in a state in which the intermittent current is supplied through the excitation body (21). The coil (3) includes a first coil part (31) wound around a first excitation part (51) of the excitation body (21), and a second coil part (32) wound around a second excitation part (52) of the excitation body (21). The first excitation part (51) and the second excitation part (52) are connected in series, and the first coil part (31) and the second coil part (32) are connected in parallel. The detection unit 9 detects the external magnetic field by detecting a common voltage generated in the first coil part (31) and the second coil part (32).

IPC Classes  ?

• G01R 33/02 - Measuring direction or magnitude of magnetic fields or magnetic flux

Abstract

This structure 1 comprises: a body 3 in which a plurality of segments 2, each of which is a sintered body of ceramics, are combined; and a surface layer 4 made of ceramics covering at least a part of a surface of the body 3.

IPC Classes  ?

• C04B 41/87 - Ceramics
• B28B 1/24 - Producing shaped articles from the material by injection moulding
• B28B 1/26 - Producing shaped articles from the material by slip-casting, i.e. by casting a suspension or dispersion of the material in a liquid-absorbent or porous mould, the liquid being allowed to soak into or pass through the walls of the mouldMoulds therefor
• B28B 1/52 - Producing shaped articles from the material specially adapted for producing articles from mixtures containing fibres
• C04B 35/80 - Fibres, filaments, whiskers, platelets, or the like
• C04B 35/111 - Fine ceramics
• C04B 37/00 - Joining burned ceramic articles with other burned ceramic articles or other articles by heating

Abstract

A communication apparatus, a network configuration system, and a communication method that are capable of improving transmission performance are provided. The communication apparatus includes a node included in a network configuration in an optical network. The node includes layers of two or more kinds of different switch granularities, and connects the layers with respect to a node of another adjacent communication apparatus. The node includes a wavelength cross-connect layer including a wavelength cross-connect switch configured to perform switching in a wavelength unit, and a fiber cross-connect layer including a fiber cross-connect switch configured to perform switching in a fiber unit. Each of the wavelength cross-connect switch and the fiber cross-connect switch may be connected with respect to the node of the another adjacent communication apparatus.

IPC Classes  ?

• H04Q 11/00 - Selecting arrangements for multiplex systems

Abstract

According to one embodiment, the augmented reality presentation system comprises a haptic presentation unit which presents a haptic sensation to the specific part, a display unit, an information acquiring unit for acquiring spatial position information of the specific part, an information setting unit for setting haptic information corresponding to the haptic sensation presented to the specific part, and an arithmetic processing unit for generating a specific part image that simulates the specific part.

IPC Classes  ?

• G06F 3/01 - Input arrangements or combined input and output arrangements for interaction between user and computer
• G02F 1/1334 - Constructional arrangements based on polymer-dispersed liquid crystals, e.g. microencapsulated liquid crystals
• G06T 13/40 - 3D [Three Dimensional] animation of characters, e.g. humans, animals or virtual beings
• G06T 19/00 - Manipulating 3D models or images for computer graphics

Abstract

Provided is a method of efficiently producing semiconductor nanoparticles that exhibit band-edge emission with a high band-edge emission purity. The method comprises performing a first heat treatment of a first mixture comprising a silver (Ag) salt, an indium (In) salt, a compound having a gallium-sulfur (Ga—S) bond, a first gallium halide, and an organic solvent, to obtain first semiconductor nanoparticles.

IPC Classes  ?

• C09K 11/62 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing gallium, indium or thallium
• B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals
• B82Y 40/00 - Manufacture or treatment of nanostructures
• H10H 20/851 - Wavelength conversion means

Abstract

A steam turbine member suppresses adhesion of scale over a long period of time without impairing corrosion resistance or the like of a turbine. A method for manufacturing a coated tubular member having a deposited amorphous carbon film “m” formed on an inner surface of a tubular member, may include attaching lids to one end and another end of a tubular member, the lids including opening portions through which a gas can be introduced and discharged. The method may include depressurizing an inside of the tubular member by discharging the gas inside the tubular member from the opening portion of the lid on the one end; generating plasma inside the tubular member by applying a negative voltage to the tubular member and introducing a plasma-forming gas “g” into the tubular member from the opening portion of the lid on the other end; and introducing a raw material gas “g” of a deposited amorphous carbon film into the tubular member from the opening portion of the lid on the other end.

IPC Classes  ?

• C23C 16/505 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating using electric discharges using radio frequency discharges
• C23C 16/04 - Coating on selected surface areas, e.g. using masks
• C23C 16/26 - Deposition of carbon only
• C23C 16/44 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating

Abstract

A prediction device (100) comprises: an information acquisition unit (102) that acquires a condition for preparing lipid particles that are composed of any of a phospholipid, an anionic lipid, and a cationic lipid, and a constituent lipid of the lipid particles; a trained model (103) that predicts the particle size distribution of the lipid particles from the acquired condition for preparing the lipid particles and the acquired constituent lipid of the lipid particles; and an output unit (104) that outputs the particle size distribution of the lipid particles predicted by the trained model (103).

IPC Classes  ?

• G16C 20/30 - Prediction of properties of chemical compounds, compositions or mixtures
• A61K 9/127 - Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
• G16C 20/70 - Machine learning, data mining or chemometrics

Abstract

Various two-residue-extended peptides can be produced by reacting a first amino acid or peptide represented by the formula: Various two-residue-extended peptides can be produced by reacting a first amino acid or peptide represented by the formula: Various two-residue-extended peptides can be produced by reacting a first amino acid or peptide represented by the formula: a halogenating agent, a tertiary amine represented by the formula: Various two-residue-extended peptides can be produced by reacting a first amino acid or peptide represented by the formula: a halogenating agent, a tertiary amine represented by the formula: Various two-residue-extended peptides can be produced by reacting a first amino acid or peptide represented by the formula: a halogenating agent, a tertiary amine represented by the formula: an amino acid N-carboxy anhydride (NCA) represented by the formula: Various two-residue-extended peptides can be produced by reacting a first amino acid or peptide represented by the formula: a halogenating agent, a tertiary amine represented by the formula: an amino acid N-carboxy anhydride (NCA) represented by the formula: Various two-residue-extended peptides can be produced by reacting a first amino acid or peptide represented by the formula: a halogenating agent, a tertiary amine represented by the formula: an amino acid N-carboxy anhydride (NCA) represented by the formula: and a second amino acid or peptide represented by the formula: Various two-residue-extended peptides can be produced by reacting a first amino acid or peptide represented by the formula: a halogenating agent, a tertiary amine represented by the formula: an amino acid N-carboxy anhydride (NCA) represented by the formula: and a second amino acid or peptide represented by the formula:

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• C07K 1/02 - General processes for the preparation of peptides in solution

Abstract

A concretion promoting material according to the present invention comprises: an ion supply material that gradually releases ions that enable formation of a hardly soluble compound; and an acid that donates protons.

IPC Classes  ?

• C09K 17/06 - Calcium compounds, e.g. lime
• C09K 17/10 - Cements, e.g. Portland cement
• C09K 17/18 - PrepolymersMacromolecular compounds
• C09K 17/44 - Inorganic compounds mixed with organic active ingredients, e.g. accelerators the inorganic compound being cement
• E02D 3/12 - Consolidating by placing solidifying or pore-filling substances in the soil
• C09K 103/00 - Civil engineering use

Abstract

In this method for designing a predictive model to be executed by a computer, the following steps are repeated until a predetermined end condition is satisfied, namely: generating a predictive model using teacher data in which a parameter set prepared on the basis of a plurality of types of parameters indicating characteristics of spring steel and test results relating to a specific characteristic of the spring steel are associated with each other; using a plurality of algorithms for outputting a ranking of a degree of contribution of each type of parameter to the test results, to rank the types of parameters of the teacher data used in the predictive model generated immediately before; and, on the basis of the ranking of the types of parameters, regenerating the predictive model using teacher data in which a parameter set having a reduced number of parameter types and the test results relating to the specific characteristic of the spring steel are associated with each other.

IPC Classes  ?

• G01N 33/20 - Metals

Abstract

The present invention addresses the problem of providing a substance having a stronger Ras inhibitory effect and/or a stronger anticancer effect. The problem is solved by a fusion protein comprising a Ras-cleaving/modifying enzyme domain and a Ras-binding domain.

IPC Classes  ?

• C07K 19/00 - Hybrid peptides
• A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 35/00 - Antineoplastic agents
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
• C07K 16/32 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products from oncogenes
• C12N 15/12 - Genes encoding animal proteins
• C12N 15/13 - Immunoglobulins
• C12N 15/57 - Hydrolases (3) acting on peptide bonds (3.4)
• C12N 15/62 - DNA sequences coding for fusion proteins

Abstract

Provided is a composition for inhibiting fibrosis of the intestinal tract, said composition comprising, as an active ingredient, a molecule that inhibits the function of the CCL19 gene.

IPC Classes  ?

• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61K 38/02 - Peptides of undefined number of amino acidsDerivatives thereof
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
• A61P 1/04 - Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• A61P 19/04 - Drugs for skeletal disorders for non-specific disorders of the connective tissue
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• C07K 16/24 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
• C12N 15/13 - Immunoglobulins
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/115 - Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith

Abstract

The present invention provides an alternate technology capable of recovering carbon dioxide. This carbon dioxide recovery system comprises: a compressor that compresses a gas containing carbon dioxide and nitrogen; a tank that stores the compressed gas; a cooler that cools the carbon dioxide contained in the gas in the tank until the carbon dioxide turns into a solid; and a heater that heats the carbon dioxide, which has turned into a solid through cooling, until the carbon dioxide turns into a liquid. In a state in which the nitrogen contained in the gas in the tank is removed, the carbon dioxide recovery system heats the solid carbon dioxide and recovers the liquid carbon dioxide.

IPC Classes  ?

• F25J 3/00 - Processes or apparatus for separating the constituents of gaseous mixtures involving the use of liquefaction or solidification
• C01B 32/55 - Solidifying

Abstract

The present invention provides a pharmaceutical composition for treating heart failure with diastolic dysfunction, comprising a retinoid as an active ingredient. The heart failure with diastolic dysfunction may be heart failure with preserved left ventricular ejection fraction, heart failure with mid-range left ventricular ejection fraction, or heart failure with reduced left ventricular ejection fraction.

IPC Classes  ?

• A61K 31/196 - Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
• A61K 31/202 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid having three or more double bonds, e.g. linolenic acid
• A61P 9/04 - Inotropic agents, i.e. stimulants of cardiac contractionDrugs for heart failure

Abstract

A robot includes a display, a camera, a communication interface, a moving mechanism, and a control unit. The control unit includes a movement control unit, a remote video image processing unit, and a local video image processing unit. The movement control unit controls the moving mechanism to move the robot. The remote video image processing unit acquires a remote video image including video images representing a plurality of remote users located at sites different from the current location of the robot from an external network via a communication interface, and displays the acquired remote video image on the display. The local video image processing unit transmits a local video image, which is a video image captured by the camera, to the external network via the communication interface to cause the plurality of remote users to view the local video image.

IPC Classes  ?

• B25J 9/16 - Programme controls
• B25J 19/04 - Viewing devices

Abstract

A walking phase determination support system includes an imaging unit configured to image a walking motion of a pedestrian; a detection unit configured to detect a change over time in a force applied to each part of a sole of the pedestrian in synchronization with imaging; an input unit configured to be operated to designate a walking-phase-to-be-determined; a display unit configured to display a video; and a control unit configured to display a moving image captured and, as display still images, still images captured at different timings from among still images forming the moving image. The control unit is configured to estimate, based on a change over time in a detection value, as a specific timing, a timing at which the walking phase becomes the walking-phase-to-be-determined, and is configured to display one display still image corresponding to the specific timing in a form associated with the walking-phase-to-be-determined.

IPC Classes  ?

• G06V 40/20 - Movements or behaviour, e.g. gesture recognition
• G06F 3/14 - Digital output to display device
• G06T 5/50 - Image enhancement or restoration using two or more images, e.g. averaging or subtraction
• G06T 7/194 - SegmentationEdge detection involving foreground-background segmentation
• G06V 20/52 - Surveillance or monitoring of activities, e.g. for recognising suspicious objects

Abstract

Provided is crRNA that is circular and includes a spacer sequence which includes a sequence that specifically recognizes and binds to a crRNA recognition sequence in target DNA, and a repeat sequence which can be cleaved by at least one Cas protein selected from the group consisting of Cas9 proteins and Cas9 proteins.

IPC Classes  ?

• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/09 - Recombinant DNA-technology
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

A manipulation system (10) is provided with: a manipulator drive mechanism (26) for moving a manipulator; an imaging device (24) for imaging a sample and the manipulator through an objective lens; an input device (34) for receiving, from a user, an input operation for designating the position of the manipulator; and a control device (30). The control device (30) is provided with: a selection unit (72) that, on the basis of time-series values pertaining to the position of the manipulator at a time when a prescribed operation for moving the manipulator is performed, selects one of a plurality of operation patterns for supporting the prescribed operation; and a calculation unit (70) that calculates operation support information for supporting the prescribed operation in accordance with the selected operation pattern.

IPC Classes  ?

• G02B 21/32 - Micromanipulators structurally combined with microscopes

Abstract

This conveyance device is provided with a track, a first conveyance unit, a second conveyance unit, a position control unit, a first position detection unit, and a second position detection unit. The first conveyance unit and the second conveyance unit are arranged side by side along the traveling direction of the track, and travel along the track to convey a workpiece. The position control unit controls the positions of the first conveyance unit and the second conveyance unit on the basis of a target position included in a conveyance command. The first position detection unit detects the position of the first conveyance unit in the traveling direction of the track. The second position detection unit detects the position of the second conveyance unit in the traveling direction of the track. The position of the first conveyance unit in the traveling direction of the track is controlled on the basis of a first position deviation. The position of the second conveyance unit in the traveling direction of the track is controlled on the basis of a value obtained by correcting a second position deviation with a correction value based on the first position deviation.

IPC Classes  ?

• G05B 19/18 - Numerical control [NC], i.e. automatically operating machines, in particular machine tools, e.g. in a manufacturing environment, so as to execute positioning, movement or co-ordinated operations by means of programme data in numerical form
• B25J 13/08 - Controls for manipulators by means of sensing devices, e.g. viewing or touching devices
• B66C 13/22 - Control systems or devices for electric drives

Abstract

An organic solar cell module 10 has a module structure in which a plurality of unit cells A each comprising a first electrode 1 and a second electrode 2 that are translucent and face opposite in the Z-direction, and a power generation laminate 7 comprising a laminated structure including an electron transport layer 3 and a hole transport layer 4 lined up in the Z-direction as well as an organic power generation layer 5 located therebetween, one of the electron transport layer 3 and the hole transport layer 4 being arranged opposite the first electrode 1 and the other being arranged opposite the second electrode 2, are arranged spaced apart between a first substrate 11 and a second substrate 12 both of which are translucent and which face opposite in the Z-direction, so that the first substrate 11 and the first electrode 1 face opposite and are lined up in the in-plane direction of the XY-plane. Between two adjacent unit cells A of the plurality of unit cells A, there is a connection wiring 6 connecting the first electrodes 1 of unit cells A1, A2 and the second electrodes 2 of unit cells A2, A3. The connection wiring 6 and the second electrodes 2 are integrally formed of carbon nanotubes.

IPC Classes  ?

• H10K 39/12 - Electrical configurations of PV cells, e.g. series connections or parallel connections
• H10K 30/40 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation comprising a p-i-n structure, e.g. having a perovskite absorber between p-type and n-type charge transport layers
• H10K 30/82 - Transparent electrodes, e.g. indium tin oxide [ITO] electrodes
• H10K 30/88 - PassivationContainersEncapsulations
• H10K 71/12 - Deposition of organic active material using liquid deposition, e.g. spin coating
• H10K 71/60 - Forming conductive regions or layers, e.g. electrodes
• H10K 77/00 - Constructional details of devices covered by this subclass and not covered by groups , , or
• H10K 77/10 - Substrates, e.g. flexible substrates
• H10K 85/00 - Organic materials used in the body or electrodes of devices covered by this subclass
• H10K 85/10 - Organic polymers or oligomers
• H10K 85/50 - Organic perovskitesHybrid organic-inorganic perovskites [HOIP], e.g. CH3NH3PbI3
• H10K 102/10 - Transparent electrodes, e.g. using graphene

Abstract

This solar cell is provided with a pair of electrodes (2, 3) and an active layer (1). The active layer is located between the pair of electrodes and absorbs light to generate electrons and holes. The pair of electrodes are composed of an electron collecting electrode (3) for collecting electrons and a hole collecting electrode (2) for collecting holes. The electron collecting electrode contains a carbon nanotube (31) and an electron donating material (32). This configuration makes it possible to provide a solar cell capable of achieving high energy conversion efficiency while reducing material costs.

IPC Classes  ?

• H10K 30/50 - Photovoltaic [PV] devices
• H10K 30/40 - Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation comprising a p-i-n structure, e.g. having a perovskite absorber between p-type and n-type charge transport layers
• H10K 30/82 - Transparent electrodes, e.g. indium tin oxide [ITO] electrodes
• H10K 85/20 - Carbon compounds, e.g. carbon nanotubes or fullerenes
• H10K 85/50 - Organic perovskitesHybrid organic-inorganic perovskites [HOIP], e.g. CH3NH3PbI3

Abstract

This method for promoting the biosynthesis of a polyphenol includes a step for performing such a treatment that an aqueous plasma irradiation solution obtained by irradiating an aqueous solution containing sodium L-lactate with atmospheric plasma is applied to a site in a plant, wherein the site is capable of biosynthesizing a polyphenol. The method for promoting the biosynthesis of a polyphenol can increase the amount of the polyphenol accumulated in the site. The treatment is preferably performed by injecting or applying the aqueous plasma irradiation solution into or to the site.

IPC Classes  ?

• A01G 7/06 - Treatment of growing trees or plants, e.g. for preventing decay of wood, for tingeing flowers or wood, for prolonging the life of plants
• A01G 22/05 - Fruit crops, e.g. strawberries, tomatoes or cucumbers
• A23B 7/14 - Preserving or ripening with chemicals not covered by group or

Abstract

This detonation combustor comprises a combustor cylinder, an oxidant supply unit for supplying an oxidant into the combustor cylinder, and a fuel supply unit for supplying fuel into the combustor cylinder. The detonation combustor burns a mixed gas of fuel and oxidant as a result of a detonation wave passing through the mixed gas. At least a portion of an inner wall surface of the combustor cylinder in the vicinity of the oxidant supply unit and the fuel supply unit is covered with solid fuel.

IPC Classes  ?

• F23R 7/00 - Intermittent or explosive combustion chambers
• B64G 1/40 - Arrangements or adaptations of propulsion systems
• F02K 9/72 - Rocket-engine plants, i.e. plants carrying both fuel and oxidant thereforControl thereof using liquid and solid propellants, i.e. hybrid rocket-engine plants
• F23M 5/00 - CasingsLiningsWalls

Abstract

This electrolyte membrane comprises an electrolyte and a fullerene derivative having the structure in formula (1) (where FLN is fullerene or a derivative thereof, R 1is an added group containing one or more carbon atoms, R 2and R 3 are each independently a substituent containing one or more polar groups; n1≥1; n2≥1; and n3≥0).

IPC Classes  ?

• H01M 8/1051 - Non-ion-conducting additives, e.g. stabilisers, SiO2 or ZrO2
• H01B 1/06 - Conductors or conductive bodies characterised by the conductive materialsSelection of materials as conductors mainly consisting of other non-metallic substances
• H01M 8/10 - Fuel cells with solid electrolytes
• H01M 8/1069 - Polymeric electrolyte materials characterised by the manufacturing processes

Abstract

A fullerene derivative having the structure in formula (1) (where FLN is fullerene or a derivative thereof, R 1is an added group containing one or more carbon atoms, R 2and R 3 are each independently a substituent containing one or more polar groups; n1≥1; n2≥1; and n3≥0).

IPC Classes  ?

• C07C 33/38 - Alcohols containing six-membered aromatic rings and other rings and having unsaturation outside the aromatic rings
• C07C 29/44 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by addition reactions, i.e. reactions involving at least one carbon-to-carbon double or triple bond
• C07C 37/00 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
• C07C 37/055 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by replacing functional groups bound to a six-membered aromatic ring by hydroxy groups, e.g. by hydrolysis by substitution of a group bound to the ring by oxygen, e.g. ether group
• C07C 39/23 - Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
• C07C 51/367 - Preparation of carboxylic acids or their salts, halides, or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in singly bound form
• C07C 65/19 - Compounds having carboxyl groups bound to carbon atoms of six-membered aromatic rings and containing any of the groups OH, O-metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups having unsaturation outside the aromatic ring
• C07C 303/02 - Preparation of esters or amides of sulfuric acidsPreparation of sulfonic acids or of their esters, halides, anhydrides or amides of sulfonic acids or halides thereof
• C07C 309/25 - Sulfonic acids having sulfo groups bound to carbon atoms of rings other than six-membered aromatic rings of a carbon skeleton
• C07F 9/40 - Esters thereof

Abstract

A fullerene derivative according to the present invention has a partial structure represented by formula (1). (In the formula, the respective moieties represented by C* are adjacent carbon atoms constituting the fullerene skeleton, and n is 1 or 2).

IPC Classes  ?

• C07C 49/697 - Unsaturated compounds containing a keto group being part of a ring containing halogen containing six-membered aromatic rings
• C07C 45/67 - Preparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by reactions not involving the formation of C=O groups by isomerisationPreparation of compounds having C=O groups bound only to carbon or hydrogen atomsPreparation of chelates of such compounds by reactions not involving the formation of C=O groups by change of size of the carbon skeleton
• H10K 85/20 - Carbon compounds, e.g. carbon nanotubes or fullerenes
• H10K 85/60 - Organic compounds having low molecular weight

Abstract

This invention accurately measures a change over time in pressure on an object with a pressure sensor without using a cuff. This pressure sensor pad is for pressing, against an object, a pressure sensor for measuring a change over time in the pressure on the object, and is formed from a porous body having an elastic coefficient of 0.1 MPa or less. The thickness of the pressure sensor pad is 3 mm to 10 mm.

IPC Classes  ?

• A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
• A61B 5/022 - Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skinOphthaldynamometers

Abstract

Provided is an executive function assessment device capable of assessing an executive function related to symptoms of neurodevelopmental disorders. An executive function assessment device (1) is for assessing an executive function related to symptoms of neurodevelopmental disorders and comprises: a memory (12) that stores operation information indicating an operation performed by an assessment subject (A) in a virtual space which is displayed on a user terminal (3) and in which a task is set; and a calculation unit (11) that assesses the executive function of the assessment subject. The calculation unit is configured to calculate an index of the execution function of the assessment subject by using the relationship of, in a plurality of virtual spaces which are displayed on the user terminal and in which tasks different from each other are set therein, information about operations performed by the assessment subject in the respective virtual spaces.

IPC Classes  ?

• A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
• G16H 20/70 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mental therapies, e.g. psychological therapy or autogenous training

Abstract

Provided is a lipid particle which includes a drug and enables more efficient development of the function of the drug in cells. The lipid particle contains, in the polar head thereof, a modified ionized lipid having a disulfide unit and/or a modified polynucleotide having a disulfide unit.

IPC Classes  ?

• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61K 9/14 - Particulate form, e.g. powders
• A61K 47/20 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
• A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• C07C 321/14 - Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
• C07C 321/18 - Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
• C07C 391/00 - Compounds containing selenium
• C07D 339/04 - Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid
• C07D 339/08 - Six-membered rings
• C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
• C12N 15/88 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using liposome vesicle
• A61K 9/51 - Nanocapsules
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical

Abstract

A compound represented by general formula (1) [wherein Ar1and Ar2each independently represent a substituted or unsubstituted aromatic hydrocarbon ring or a substituted or unsubstituted heteroaromatic ring; R1and R2each independently represent a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted cycloalkyl group, or a substituted or unsubstituted (hetero)aryl group, wherein R1and R2together may form a ring in conjunction with the adjacent nitrogen atom, and R1and/or R2and Ar2together may form a ring in conjunction with the adjacent nitrogen atom; R3and R4each independently represent a substituted or unsubstituted (hetero)aryl group; and R5 represents a hydrogen atom, a substituted or unsubstituted alkyl group, or a substituted or unsubstituted cycloalkyl group] can fluorescently dye a mitochondria (in particular, a mitochondrial inner membrane) selectively although the compound is a small molecule.

IPC Classes  ?

• C09B 57/00 - Other synthetic dyes of known constitution
• C07B 61/00 - Other general methods
• C07D 333/58 - Radicals substituted by nitrogen atoms
• C07F 9/6553 - Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
• C07F 9/6578 - Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and sulfur atoms with or without oxygen atoms, as ring hetero atoms
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials

Abstract

This protein transport material contains a polycyclic compound having, in the main skeleton, one or two structures represented by general formula (1) (In the formula, Ar1represents a condensed aromatic ring optionally having a substituent with the proviso that when R is a group having a primary, secondary or tertiary amino group or R is a group having a nitrogen cation-containing group, Ar1is a condensed aromatic ring that is other than a perylene diimide ring and optionally has a substituent; R represents an anionic group or a cationic group; n represents an integer of 1 or more; and when n is an integer of 2 or more, the n number of Rs may be the same or different.) or general formula (5) (In the formula, R17and R18 are the same or different and each represent an aryl group optionally having a substituent.). The protein transport material uses precisely synthesizable small molecules, has excellent protein transport efficiency, and is capable of transporting a protein into cells.

IPC Classes  ?

• A61K 47/14 - Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• A61K 38/00 - Medicinal preparations containing peptides
• A61K 38/47 - Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
• A61K 38/48 - Hydrolases (3) acting on peptide bonds (3.4)
• A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
• A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• C07C 69/76 - Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a six-membered aromatic ring
• C07C 211/03 - Monoamines
• C07C 217/18 - Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
• C07D 241/04 - Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
• C07D 249/06 - 1,2,3-TriazolesHydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
• C07D 249/16 - Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
• C07D 249/22 - Naphthotriazoles
• C07D 295/033 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
• C07D 295/037 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements with quaternary ring nitrogen atoms
• C07D 487/04 - Ortho-condensed systems
• C12N 15/09 - Recombinant DNA-technology

Abstract

Semiconductor nanoparticles 10 having a core-shell structure in which a coating layer 12 containing an In component as a main component is formed on the surface of a core particle 11 formed from a compound semiconductor having an Ag component, a Ge component, and a S component as main components.

IPC Classes  ?

• C09K 11/66 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing germanium, tin or lead
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• B82Y 40/00 - Manufacture or treatment of nanostructures
• C01G 17/00 - Compounds of germanium
• C09K 11/58 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing copper, silver or gold
• C09K 11/62 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing gallium, indium or thallium

Abstract

Semiconductor nanoparticles including Ag, In, Ga, and S are provided. In the semiconductor nanoparticles, a ratio of a number of Ga atoms to a total number of In and Ga atoms is 0.95 or less. The semiconductor nanoparticles emit light having an emission peak with a wavelength in a range of from 500 nm to less than 590 nm, and a half bandwidth of 70 nm or less, and have an average particle diameter of 10 nm or less.

IPC Classes  ?

• H10H 20/851 - Wavelength conversion means
• C09K 11/62 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing gallium, indium or thallium
• H10H 20/01 - Manufacture or treatment
• H10H 20/812 - Bodies having quantum effect structures or superlattices, e.g. tunnel junctions within the light-emitting regions, e.g. having quantum confinement structures

Abstract

An object is to provide a surgery support system that can ensure a better field. The object can be achieved by a surgery support system including a surgical assistance device, an image processing unit, and a display unit. The image capturing units are configured such that a plurality of image capturing units are provided to the surgical assistance device, the image capturing units captures an image so that inside of the body cavity appears in the image, and when the treatment tool is inserted in the body cavity, the image capturing units captures an image so that the inside of the body cavity including the treatment tool appears in the image, and the image processing unit is configured to synthesize images obtained from image capturing units to generate synthesized image, and perform an obstructing object removal process of removing at least a part of image of the treatment tool.

IPC Classes  ?

• A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
• A61B 1/045 - Control thereof
• A61B 17/00 - Surgical instruments, devices or methods
• A61B 17/29 - Forceps for use in minimally invasive surgery
• G06T 5/50 - Image enhancement or restoration using two or more images, e.g. averaging or subtraction
• G06T 5/77 - RetouchingInpaintingScratch removal
• G06T 7/13 - Edge detection
• G06T 7/55 - Depth or shape recovery from multiple images
• G06T 7/73 - Determining position or orientation of objects or cameras using feature-based methods
• G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation

Abstract

The present invention provides: an electrode for a power storage device that makes it possible to achieve high charge/discharge performance, that has a simple configuration, and that is easily manufactured; and a power storage device that includes said electrode. The electrode is used in a chargeable/dischargeable power storage device which includes a first electrode and a second electrode and in which metal atoms that have been ionized in the second electrode is deposited on the first electrode during charging. The electrode constitutes the first electrode and includes a metal substrate such that: a two-dimensional Debye ring diffraction image by a two-dimensional X-ray detector is obtained as a discontinuous arc-shaped image in which points or line segments are arranged; and the metal atoms are deposited on the surface of the metal substrate during charging of the power storage device.

IPC Classes  ?

• H01M 4/134 - Electrodes based on metals, Si or alloys
• H01M 4/1395 - Processes of manufacture of electrodes based on metals, Si or alloys
• H01M 4/66 - Selection of materials
• H01M 10/052 - Li-accumulators
• H01M 10/0566 - Liquid materials
• H01M 10/058 - Construction or manufacture

Abstract

A method for identifying geometric errors in a machine tool includes the steps of: positioning a reference sphere so as to align its center with a centerline of a tool spindle; attaching a position measuring device having a gauge head to a rotation unit so as to direct the gauge head toward a rotation centerline of the rotation unit; acquiring displacement data relative to the center of the reference sphere by measuring positions of the reference sphere with the gauge head while rotating a rotation target (the swivel unit or the rotation unit) with the gauge head directed toward the center of the reference sphere, the displacement data being dependent on rotation angles of the rotation target; and identifying the geometric errors by least squares method using a mathematical expression having terms containing the geometric errors and representing displacement dependent on the rotation angles, and the displacement data.

IPC Classes  ?

• G01B 5/25 - Measuring arrangements characterised by the use of mechanical techniques for measuring angles or tapersMeasuring arrangements characterised by the use of mechanical techniques for testing the alignment of axes for testing the alignment of axes
• B23B 13/02 - Arrangements for automatically conveying, chucking or guiding stock for turning machines for turning-machines with a single working-spindle
• G01B 5/008 - Measuring arrangements characterised by the use of mechanical techniques for measuring coordinates of points using coordinate measuring machines

Abstract

The present invention addresses the problem of providing: a bioelectrode for measuring an intestinal action potential to predict the timing of defecation on the basis of the waveform of the potential; and an intestinal potential measurement apparatus and a defecation prediction method each using the bioelectrode. A bioelectrode (2) has a sheet body (3) including a flexible sheet having a back surface (31) as an adhesive surface (31). The sheet body (3) has: a plurality of electrode pad portions (300, 301) which are arranged so as to be scattered along the large intestinal tract (91), and in which electrodes (4) for acquiring an intestinal potential are exposed on the back surface (31); central device receiving portions (310, 301) which are arranged within an area in which the plurality of electrode pad portions (300, 301) are connected in a ring shape, the central device receiving portions (310, 301) exposing, on an upper surface (30), a plurality of receiving connectors (311) for electrically connecting to connectors (50) of an intestinal electrometer (5) and a plurality of receiving portions (312) for receiving temporary fixation portions (51) of the intestinal electrometer (5); and lead extension portions (320, 321) on which lead wires (322) respectively connecting the plurality of electrode pad portions (300, 301) and the plurality of receiving connectors (311) are fixed.

IPC Classes  ?

• A61B 5/392 - Detecting gastrointestinal contractions
• A61B 5/257 - Means for maintaining electrode contact with the body using adhesive means, e.g. adhesive pads or tapes

Abstract

xyy (wherein x and y are each 1 or more), having a phosphorus atom, and at least one saturated hydrocarbon group in the main chain, and a basic polymer (3) that contains a basic functional group, while having at least one aromatic ring in the main chain, wherein an attractive interaction occurs between the oxo acid group and the basic functional group. This fuel cell is provided with the proton conductive electrolyte material. This method for producing a proton conductive electrolyte material includes: preparing a first solution by means of an acidic polymer and a mixed solvent; preparing a second solution in which a basic polymer is dissolved in a solvent; and preparing a mixed solution in which the first solution and the second solution are mixed. With respect to the preparation of the first or second solution, a mixed solvent which contains an inhibitor that is capable of inhibiting rapid aggregation of the oxo acid group and the basic functional group is prepared.

IPC Classes  ?

• H01M 8/103 - Polymeric electrolyte materials characterised by the chemical structure of the main chain of the ion-conducting polymer having nitrogen, e.g. sulfonated polybenzimidazoles [S-PBI], polybenzimidazoles with phosphoric acid, sulfonated polyamides [S-PA] or sulfonated polyphosphazenes [S-PPh]
• C08L 25/18 - Homopolymers or copolymers of aromatic monomers containing elements other than carbon and hydrogen
• C08L 79/08 - PolyimidesPolyester-imidesPolyamide-imidesPolyamide acids or similar polyimide precursors
• C08L 101/00 - Compositions of unspecified macromolecular compounds
• H01B 1/06 - Conductors or conductive bodies characterised by the conductive materialsSelection of materials as conductors mainly consisting of other non-metallic substances
• H01M 4/86 - Inert electrodes with catalytic activity, e.g. for fuel cells
• H01M 8/10 - Fuel cells with solid electrolytes
• H01M 8/102 - Polymeric electrolyte materials characterised by the chemical structure of the main chain of the ion-conducting polymer
• H01M 8/1044 - Mixtures of polymers, of which at least one is ionically conductive
• H01M 8/1081 - Polymeric electrolyte materials characterised by the manufacturing processes starting from solutions, dispersions or slurries exclusively of polymers

Abstract

The present invention provides a technique for forming a p-type region in a nitride semiconductor. A semiconductor device manufacturing method includes an ion implantation step for ion-implanting beryllium on the surface of a compound semiconductor substrate containing aluminum. The manufacturing method includes an annealing step for annealing the compound semiconductor substrate after the ion implantation step so that an aluminum atom is substituted with a beryllium atom.

IPC Classes  ?

• H01L 21/265 - Bombardment with wave or particle radiation with high-energy radiation producing ion implantation
• H10D 30/01 - Manufacture or treatment
• H10D 30/60 - Insulated-gate field-effect transistors [IGFET]

Abstract

A method of desulfurizing sulfur-crosslinked rubber includes adding at least one selected from the group consisting of primary and secondary phosphine oxides and analogues of the primary and secondary phosphine oxides, primary and secondary phosphines which become oxides when oxidized and analogues of the primary and secondary phosphines, sulfenic acid, and sulfinic acid as a desulfurizing agent that acts on a sulfur bond in the sulfur-crosslinked rubber and cleaves the sulfur bond to the sulfur-crosslinked rubber, and performing heating.

IPC Classes  ?

• C08C 19/30 - Addition of a reagent which reacts with a hetero atom or a group containing hetero atoms of the macromolecule

Abstract

The present invention provides a natural product-derived substance having an anti-inflammatory effect. It was found that a composition extracted from watermelon staminate flowers has the ability to suppress production of nitric oxide by macrophages, leading to the conception of an anti-inflammatory composition extracted from watermelon staminate flowers according to the present invention. An anti-inflammatory composition extracted from watermelon staminate flowers according to the present invention was confirmed to reduce the concentration of nitric oxide in cells in a concentration-dependent manner, and is expected to be suitably used in therapeutic agents against sepsis and autoimmune diseases. In addition, the anti-inflammatory composition is considered to have few side effects because of being derived from watermelon. Further, the anti-inflammatory composition can be expected to serve as an alleviation agent for some autoimmune diseases since the anti-inflammatory composition is considered to suppress iNOS induction and TNF-α production by inhibiting the activation of NF-κB.

IPC Classes  ?

• A61K 36/42 - Cucurbitaceae (Cucumber family)
• A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 31/04 - Antibacterial agents
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• A61K 133/00 - Containing or obtained from flowers or blossoms

Abstract

Provided is a cell culture or growth substrate that enables cells to be separated more easily without the use of a drug. Provided is a cell culture or growth substrate that enables cells to be separated more easily without the use of a drug. A cell culture or growth substrate comprising a composition in gel form or gel-forming sol form, or a dried product of the composition, the composition comprising a polypeptide comprising an elastin-like block peptide sequence that comprises a G sequence block consisting of (SEQ ID NO: 1: X1GGX2G)n, wherein each X1 is the same or different and represents V or L, each X2 is the same or different and represents V or L, and n represents an integer of 4 or more, and a P sequence block consisting of (SEQ ID NO: 2: VPGX3G)m, wherein each XV is the same or different and represents any amino acid, and m represents an integer of 5 or more.

IPC Classes  ?

• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor

Abstract

An electromagnetic wave input/output element 1 attachable to a waveguide includes a dielectric three dimensional object 10 in the shape of a parallelepiped. The ratio b/c of the length b of the long side of the aperture surface of the parallelepiped and the length c of the side of the parallelepiped in the direction perpendicular to the aperture surface is smaller than 0.75.

IPC Classes  ?

• H01Q 13/24 - Non-resonant leaky-waveguide or transmission-line antennas Equivalent structures causing radiation along the transmission path of a guided wave constituted by a dielectric or ferromagnetic rod or pipe

Abstract

A stacked body, including a reflective electrode layer, an intermediate layer having a MgZnO composition, and a semiconductor layer having an AlGaN composition in this order, where a thickness of the intermediate layer is 1-80 nm. An emitting device containing the stacked body. A method of producing the stacked body.

IPC Classes  ?

• H10H 20/832 - Electrodes characterised by their material
• H10H 20/825 - Materials of the light-emitting regions comprising only Group III-V materials, e.g. GaP containing nitrogen, e.g. GaN

Abstract

An observation device according to the present disclosure is for observing a cell suspension containing a plurality of cells. This observation device comprises: at least one irradiation unit that is disposed at a position opposing a cell suspension, and that irradiates the cell suspension with irradiation light that has at least one wavelength included in the ranges of 650-850 nm and 1060-1090 nm; at least one light-receiving unit that is disposed at a position opposing the cell suspension, and that receives emitted light emitted from the cell suspension, as a result of the cell suspension being irradiated with the irradiation light; and an analysis unit that is communicably connected to the light-receiving unit, and that obtains, on the basis of the intensity of the emitted light, a parameter relating to the cell concentration of the cells in the cell suspension.

IPC Classes  ?

• G01N 21/359 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• C12Q 1/06 - Quantitative determination
• G01N 15/01 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells

Abstract

An observation device according to the present disclosure is for observing the state of a cell population comprising of a plurality of cells. The observation device comprises: at least one irradiating unit which is disposed in a position facing the cell population, and which irradiates at least one irradiation region set in the cell population with irradiating light having at least one wavelength included in the ranges of 650 to 850 nm and 1060 to 1090 nm; at least one light receiving unit which is disposed in a position facing the cell population and which receives emitted light emitted from the cell population as a result of the irradiation of the irradiation region with the irradiating light; and an analyzing unit which is communicably connected to the light receiving unit, and which obtains, on the basis of the intensity of the emitted light, a parameter that includes at least one of the number of cells and the cell density of the cell population in the irradiation region.

IPC Classes  ?

• G01N 21/359 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• C12Q 1/06 - Quantitative determination
• G01N 15/01 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells

Abstract

Provided is a more efficient method for producing a glycopeptide sample with a higher ratio of glycopeptides to non-glycopeptides. The method for producing a glycopeptide sample includes: (3) a step of bringing particles that retain a protein on the surface thereof into contact with a protease; (4) a step of adding an organic solvent after step (3); and (5) a step of washing the particles obtained in step (4). The particles are cellulose-coated particles. An ion pair agent is added together with the organic solvent in step (4).

IPC Classes  ?

• G01N 27/62 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosolsInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electric discharges, e.g. emission of cathode

Abstract

A filtering apparatus includes a cylindrical filter including a cylindrical screen filter, a treated water nozzle including a nozzle port, a casing where the cylindrical filter is accommodated, the casing containing the nozzle port in the inside, a filtered water flow channel through which filtered water obtained by passage of water to be treated through the screen filter is guided to the outside of the casing, the filtered water flow channel being provided with a flow inlet provided in the inside of the casing, and a rotation mechanism that rotates the cylindrical filter with a central axis of the cylindrical filter. A distance between a centerline of the nozzle port along a direction of outflow of water to be treated and the central axis of the cylindrical filter is shorter than a radius of the cylindrical filter.

IPC Classes  ?

• B01D 33/067 - Construction of the filtering drums, e.g. mounting or sealing arrangements
• B01D 24/46 - Regenerating the filtering material in the filter
• B01D 33/46 - Regenerating the filter material in the filter by scrapers, brushes or the like acting on the cake-side of the filtering element
• B01D 33/58 - Handling the filter cake in the filter for purposes other than for regenerating
• C02F 1/00 - Treatment of water, waste water, or sewage

Abstract

The present invention provides a plant body having improved growth ability.　Provided is a genome-edited plant body that includes a base insertion and/or base deletion mutation in a promoter of the AHA2 gene or an ortholog gene thereof, wherein the level of the AHA2 protein or the ortholog protein thereof in the leaves is improved by the mutation.

IPC Classes  ?

• A01H 5/00 - Angiosperms, i.e. flowering plants, characterised by their plant partsAngiosperms characterised otherwise than by their botanic taxonomy
• A01H 1/00 - Processes for modifying genotypes
• A01H 5/10 - Seeds
• A01H 6/20 - Brassicaceae, e.g. canola, broccoli or rucola
• C12N 15/09 - Recombinant DNA-technology
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/29 - Genes encoding plant proteins, e.g. thaumatin

Abstract

A signal detection device 1 comprises: an electro/optical conversion element 13 for modulating a first optical signal having a first frequency and a second optical signal having a second frequency using an electric signal; an optical filter for extracting light of a band including the second optical signal and a side band signal of the first optical signal, and also extracting light of a band including the first optical signal and a side band signal of the second optical signal; a first photodiode 16 for generating a first intermediate frequency signal from the second optical signal and the side band signal of the first optical signal; and a second photodiode 17 for generating a second intermediate frequency signal from the first optical signal and the side band signal of the second optical signal. The signal detection device detects an electro-optical signal on the basis of a difference between an output from the first photodiode and an output from the second photodiode.

IPC Classes  ?

• H04B 10/80 - Optical aspects relating to the use of optical transmission for specific applications, not provided for in groups , e.g. optical power feeding or optical transmission through water

Abstract

The present invention provides a bacteriophage having bacteriolytic activity against Pseudomonas aeruginosa, the bacteriophage genome comprising a nucleic acid sequence represented in the genome of a bacteriophage identified by accession numbers NITE BP-04040, NITE BP-04031, NITE BP-04033, NITE BP-04036, NITE BP-04034, NITE BP-04035, accession number NITE ABP-04200, or accession number NITE ABP-04201. The present invention also provides a bacteriophage having bacteriolytic activity against Pseudomonas aeruginosa, the bacteriophage including a nucleic acid sequence encoding a tail fiber gene including at least a portion of a tail fiber gene derived from another bacteriophage and/or a nucleic acid sequence encoding at least one protein or active domain selected from the group consisting of (a) Pyocin G, (b) PslGh, and (c) PelAh.

IPC Classes  ?

• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
• A61K 35/76 - VirusesSubviral particlesBacteriophages
• A61P 31/04 - Antibacterial agents
• C12N 7/01 - Viruses, e.g. bacteriophages, modified by introduction of foreign genetic material
• C12N 15/09 - Recombinant DNA-technology

Abstract

To provide a resin molded body having AlN whiskers with excellent thermal conductivity, and a method for producing the same. The resin molded body includes at least, AlN whiskers each having a fibrous AlN single-crystal body having a surface and an oxygen-containing layer covering the surface of the fibrous AlN single-crystal body, and a resin material, wherein a weight ratio of the AlN whiskers is in a range of 3.0 wt % or more and 65.0 wt % or less.

IPC Classes  ?

• C08J 5/24 - Impregnating materials with prepolymers which can be polymerised in situ, e.g. manufacture of prepregs
• C08J 3/12 - Powdering or granulating
• C08K 9/02 - Ingredients treated with inorganic substances

Abstract

A total primary combustion burner which includes a burner body with an air-fuel mixture chamber into which an air-fuel mixture of a fuel gas and primary air is supplied, a combustion plate portion covering an opening surface, which faces the air-fuel mixture chamber, of the burner body, and a backfire suppressing plate portion disposed opposite the combustion plate portion with a gap inside the air-fuel mixture chamber. The air-fuel mixture passing through the backfire suppressing plate portion ejects from the combustion plate portion and undergoes combustion. The total primary combustion burner is configured so that backfire can be suppressed as much as possible while suppressing pressure loss, even when using hydrogen as the fuel gas. The backfire suppressing plate portion has a sintered sheet obtained by sintering a laminate made by sintering an aggregate of metallic fibers or beads.

IPC Classes  ?

• F23D 14/82 - Preventing flashback or blowback
• F23D 14/02 - Premix gas burners, i.e. in which gaseous fuel is mixed with combustion air upstream of the combustion zone
• F23D 14/14 - Radiant burners using screens or perforated plates
• F23N 5/02 - Systems for controlling combustion using devices responsive to thermal changes or to thermal expansion of a medium

Abstract

A method for efficiently culturing mesenchymal stem cells (MSCs) on hollow fiber membranes and an object for applying cultured MSCs on hollow fiber membranes to diseases. MSCs are cultured by a method that includes: a step of hydrophilizing the outer luminal surface of a hollow fiber membrane; a step of placing the hydrophilized hollow fiber membrane in a culture solution for seeding MSCs on the outer luminal surface; and a step of culturing MSCs under conditions of applying hydrodynamic loading into the hollow fiber membrane with the cells seeded thereon. A column cartridge containing MSCs and the hollow fiber membrane, wherein the MSCs are adhered in multiple layers to the outer luminal surface of the hollow fiber membrane are present for therapeutic devices.

IPC Classes  ?

• C12N 5/0775 - Mesenchymal stem cellsAdipose-tissue derived stem cells
• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means

Abstract

This skin model for surgical practice has a skin simulation layer (62), a subcutaneous tissue simulation layer (63), and a muscle simulation layer (64). Each layer of the skin simulation layer (62), the subcutaneous tissue simulation layer (63), and the muscle simulation layer (64) is formed of an elastomer. The muscle simulation layer (64), the subcutaneous tissue simulation layer (63), and the skin simulation layer (62) are laminated in this order. A mold release agent is attached between adjacent layers of the skin simulation layer (62), the subcutaneous tissue simulation layer (63), and the muscle simulation layer (64).

IPC Classes  ?

• G09B 23/30 - Anatomical models
• G09B 9/00 - Simulators for teaching or training purposes

Abstract

This adhesive agent is a phosphorus-containing molten salt solution that is used in order to join powder materials together, or to join a powder material and a thin film material. The adhesive agent satisfies the following: (1) containing an ion conductive species and a phosphorus-containing compound which is an ion conductor precursor; (2) containing a phosphorus-containing molten salt as an ion conductor precursor, the phosphorus-containing molten salt being a salt of an ion conductive species of phosphoric acid; or (3) containing a phosphorus-containing molten salt as an ion conductor precursor, and having an ion conductive species on the surface of the powder material.

IPC Classes  ?

• C09J 1/00 - Adhesives based on inorganic constituents
• H01M 4/13 - Electrodes for accumulators with non-aqueous electrolyte, e.g. for lithium-accumulatorsProcesses of manufacture thereof
• H01M 4/139 - Processes of manufacture
• H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
• H01M 10/0562 - Solid materials

Abstract

This vehicle-mounted device is communicably connected to a plurality of vehicle-mounted ECUs that are mounted in a vehicle, and is provided with a control unit for performing processing related to reliability data transmitted from each of the plurality of vehicle-mounted ECUs, wherein: the reliability data transmitted from the vehicle-mounted ECUs includes an evaluation result of the correctness of other vehicle-mounted ECUs other than the vehicle-mounted ECU that is the transmission source; and the control unit receives the reliability data transmitted from each of the plurality of vehicle-mounted ECUs, and identifies an abnormal vehicle-mounted ECU among the plurality of vehicle-mounted ECUs on the basis of the received reliability data.

IPC Classes  ?

• H04L 43/08 - Monitoring or testing based on specific metrics, e.g. QoS, energy consumption or environmental parameters
• H04L 12/28 - Data switching networks characterised by path configuration, e.g. LAN [Local Area Networks] or WAN [Wide Area Networks]
• H04L 43/02 - Capturing of monitoring data

Abstract

In this method for searching for a crystal structure of an inorganic material, a model (GM) is trained to include a first function for receiving, as an input, material information relating to the crystal structure of the inorganic material and outputting a latent variable in a latent space (LS) corresponding to the material information, and a second function for receiving, as an input, the latent variable in the latent space (LS) and outputting the sample information. The search method additionally includes identifying the crystal structure of an inorganic material having a score that is close to or greater than a prescribed target score using an optimization algorithm from the trained model.

IPC Classes  ?

• G06N 99/00 - Subject matter not provided for in other groups of this subclass
• G06N 3/0455 - Auto-encoder networksEncoder-decoder networks
• G16C 20/70 - Machine learning, data mining or chemometrics
• G16C 60/00 - Computational materials science, i.e. ICT specially adapted for investigating the physical or chemical properties of materials or phenomena associated with their design, synthesis, processing, characterisation or utilisation

Abstract

The present invention relates to semiconductor nanoparticles comprising an AgCu chalcogen compound that contains Ag, Cu, and a chalcogen element (Ch) and is represented by formula. The present invention essentially contains Te as the chalcogen element. By applying Te having a relatively large mass among the chalcogen elements, the optical response characteristics are shifted to the long wavelength side. The semiconductor nanoparticles according to the present invention contain 90 atom% or more of the AgCu chalcogen compound, and has an absorption edge wavelength on the long wavelength side in the absorption spectrum of 1,200 nm or more. In the formula, Ch is a chalcogen element. x, y, and z represent the number of atoms of Ag, Cu and the chalcogen element, respectively, and 0.2≤z(x+y)≤1. In addition, 1.0≤x/y≤10.0.

IPC Classes  ?

• C09K 11/88 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing selenium, tellurium or unspecified chalcogen elements
• B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals
• C01B 19/00 - SeleniumTelluriumCompounds thereof
• C09K 11/08 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials

Abstract

A hydrogen combustion burner utilizing hydrogen gas as a fuel gas includes a burner body with an air-fuel mixture chamber into which an air-fuel mixture of hydrogen gas and primary air is supplied and a combustion plate portion covering an opening surface, which faces the air-fuel mixture chamber, of the burner body. In the hydrogen combustion burner, the air-fuel mixture ejects from the combustion plate portion and undergoes combustion. The hydrogen combustion burner is configured to effectively suppress backfire. The combustion plate portion includes a sintered sheet by sintering an aggregate of metallic fibers, and the aggregate is not formed by weaving or knitting the metallic fibers.

IPC Classes  ?

• F23D 14/16 - Radiant burners using permeable blocks
• F23D 14/82 - Preventing flashback or blowback

Abstract

A physical secondary battery (100) comprises: a first electrode (10); a second electrode (20); and a p-type semiconductor layer (30) disposed between the first electrode (10) and the second electrode (20).

IPC Classes  ?

• H01G 11/56 - Solid electrolytes, e.g. gelsAdditives therein

Abstract

A humanized antibody or a functional fragment thereof binding to a human-derived Eval protein, an antibody-drug conjugate comprising the humanized antibody or a functional fragment thereof, or a chimeric antigen receptor comprising an antibody or a functional fragment thereof binding to a human-derived Eval protein.

IPC Classes  ?

• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• A61K 40/11 - T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cellsLymphokine-activated killer [LAK] cells
• A61K 40/31 - Chimeric antigen receptors [CAR]
• A61K 40/42 - Cancer antigens
• A61P 35/00 - Antineoplastic agents
• C07K 14/725 - T-cell receptors
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants

Abstract

The present invention provides an article visual inspection method and a rationale-generative estimation method using a large vision–language model.　The article visual inspection method comprises: a pretraining step of performing context-sensitive pretraining by inputting information containing images and sentences into a large vision–language model; an additional training step of performing additional training by inputting training information on a good-quality group and training information on a poor-quality group of a plurality of articles into the large vision–language model; and an inspection step of inputting a visual appearance image for inspection into the large vision–language model and causing the large vision–language model to output an inspection result. The article visual inspection method is characterized in that the training information on a good-quality group includes visual appearance images of good-quality articles and text information about good-quality articles, the training information on a poor-quality group includes visual appearance images of poor-quality articles and text information about poor-quality articles, and the information to be inspected includes an image to be inspected and text information requesting an inspection result. The estimation method comprises: a pretraining step of performing pretraining by inputting a plurality of datasets into a large vision–language model, each dataset containing a single image paired with a sentence containing a specified subject's preference information regarding the image; and a result outputting step of inputting an image of an object to be estimated into the large vision–language model and causing the large vision–language model to output an estimation result regarding individual preference and a rationale. The specified subject's preference information includes a judgment of whether or not the subject prefers the single image and text information indicating a rationale for the judgment.

IPC Classes  ?

• G01N 21/88 - Investigating the presence of flaws, defects or contamination
• G06F 16/9032 - Query formulation
• G06Q 50/04 - Manufacturing
• G06T 7/00 - Image analysis
• G06V 10/70 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning

Abstract

This magnetic bearing apparatus is provided with a stator core (15) that accommodates axial coils (10A, 10B) and radial coils (12A-12D). The stator core (15) is provided with: second axial stator cores (17A, 17B) positioned on both sides of a second disk (8) and between the second disk (8) and the axial coils (10A, 10B); a plurality of radial stator cores (18) around which the radial coils (12A-12D) are wound; and first axial stator cores (19A, 19B) positioned on both sides of a first disk (7).

IPC Classes  ?

• F16C 32/04 - Bearings not otherwise provided for using magnetic or electric supporting means

Abstract

The present invention provides a prophylactic and/or therapeutic agent for cystic kidney diseases. Provided is a prophylactic and/or therapeutic agent for cystic kidney diseases comprising a single-strand oligonucleotide that includes a base sequence which is complementary to at least a portion of a base sequence of miR-21.

IPC Classes  ?

• A61K 31/688 - Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols both hydroxy compounds having nitrogen atoms, e.g. sphingomyelins
• A61K 31/7125 - Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

An object of the present invention is to provide a method capable of more easily screening for, with higher accuracy, a sequence that regulates display efficiency in a polynucleotide display method. The problem is solved by a method for screening for a sequence that regulates display efficiency in a polynucleotide display method, the screening method including steps of: (a) binding a polynucleotide-polypeptide complex, which is obtained through translation by a cell-free translation system from a polynucleotide including a polypeptide encoding sequence and random sequences, to a solid phase via a modification substance on the polypeptide in the polynucleotide-polypeptide complex; and (b) selecting a random sequence by using, as an index, a ratio (enrichment factor) of appearance frequency of each random sequence in the polynucleotide-polypeptide complex bound to the solid phase with respect to appearance frequency of each random sequence in the polynucleotide.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA

Abstract

A method for generating MXene includes: bringing a starting material containing MAX phase 10 having a chemical formula of Mn+1AXn or multilayer MXene 16 in which a plurality of monolayer MXenes 20 having a chemical formula of Mn+1Xn are bonded to each other by an element A into contact with a treatment solution containing a first solvent as a polar solvent, a second solvent as an organic solvent, and tetramethylammonium salt so as to remove the element A from the starting material to produce delaminated monolayer MXene 20.

IPC Classes  ?

• C01B 32/921 - Titanium carbide
• B82Y 40/00 - Manufacture or treatment of nanostructures

Abstract

The present disclosure provides a medicine for treating or preventing a hereditary disease, etc. The present disclosure provides a medicine for altering, preventing, or treating a condition, disease, disorder or symptom, which is caused by a frame-shift mutation due to the insertion or deletion of one or more bases, by cleaving at least one a target nucleic acid sequence in a nucleic acid within a cell, said medicine comprising a vector. This vector contains a construct that contains a promoter specific to the cell, a sequence encoding a Cas nuclease, a promoter enabling the expression of a gRNA in the cell after the introduction of the vector, and a sequence encoding a gRNA that binds to a target nucleic acid sequence having the insertion or deletion. This construct is configured so as to form a cleavage site, by the Cas nuclease, in proximity to the target nucleic acid sequence having the insertion or deletion.

IPC Classes  ?

• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• A61P 27/02 - Ophthalmic agents
• C12N 9/22 - Ribonucleases
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/86 - Viral vectors

Abstract

The present invention relates to a semiconductor nanoparticle composed of a compound containing Ag, Au, S and a metal M as essential constitutional elements. In the present invention, the metal M is at least any of Al, Ga, In, Tl, Zn, Cd, Hg and Cu, and the compound has a total content of Ag, Au, S and the metal M of 95 mass % or more. In addition, a ratio (x/(x+y)) of the number of atoms of Ag to a sum of the number of atoms of Ag, x, and the number of atoms of Au, y, in the AgAuS-based multicomponent compound is preferably 0.50 or more and 0.88 or less. The semiconductor nanoparticle of the present invention has appropriate emission and extinction characteristics and is biocompatible.

IPC Classes  ?

• C09K 11/62 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing gallium, indium or thallium
• C01G 7/00 - Compounds of gold
• C09K 11/02 - Use of particular materials as binders, particle coatings or suspension media therefor
• C09K 11/58 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing inorganic luminescent materials containing copper, silver or gold
• B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals
• B82Y 40/00 - Manufacture or treatment of nanostructures

Abstract

A polarization microscope 1 includes a sample stage 4 on which a sample 8 is placed, a polarizer 3 provided on a side of the sample 8 toward a light source, and an analyzer 6 provided on a side of the sample toward an observer. At least one of the polarizer 3 and the analyzer 6 is placed such that a polarization direction is inclined with respect to an optical main axis of the sample 8 or placed such that an angle formed by a polarization direction of the analyzer 6 and a polarization direction of the polarizer is deviated from a right angle.

IPC Classes  ?

• G01N 21/88 - Investigating the presence of flaws, defects or contamination
• G01N 21/84 - Systems specially adapted for particular applications
• G01N 21/95 - Investigating the presence of flaws, defects or contamination characterised by the material or shape of the object to be examined
• G02B 21/00 - Microscopes
• G06T 7/00 - Image analysis

Abstract

Provided are an agent containing RNA as an active ingredient and capable of strongly activating cells, and uses thereof. An RNA containing a base sequence represented by SEQ ID NO: 1 or a base sequence having 90% or more identity with the sequence has a cell activating ability.

IPC Classes  ?

• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides
• A61K 31/712 - Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
• A61K 31/7115 - Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
• A61P 35/00 - Antineoplastic agents
• A61P 35/04 - Antineoplastic agents specific for metastasis
• A61P 37/04 - Immunostimulants
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12N 15/24 - Interleukins
• C12N 15/26 - Interleukin-2

Abstract

This complex for use in tumor chemodynamic therapy comprises: nanoparticles that enclose iron oxide and include a hydrophilic polymer in a surface layer thereof; and target recognition molecules that bind to the nanoparticles and can bind to target molecules of the tumor cells.

IPC Classes  ?

• A61K 33/26 - IronCompounds thereof
• A61K 33/40 - Peroxides
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 47/36 - PolysaccharidesDerivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• A61K 49/00 - Preparations for testing in vivo
• A61K 49/16 - AntibodiesImmunoglobulinsFragments thereof
• A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• A61P 35/00 - Antineoplastic agents

Abstract

A UV-emitting element (1) has a layered structure comprising, in order: an active layer (13) containing a Group III-V nitride semiconductor; a p-AlGaN layer (15); a UV transparent electrode layer (16); and a p-type contact electrode (17).

IPC Classes  ?

• H10H 20/833 - Transparent materials
• H10H 20/825 - Materials of the light-emitting regions comprising only Group III-V materials, e.g. GaP containing nitrogen, e.g. GaN

Abstract

A nucleic acid delivery material comprising a polycyclic aromatic compound having one or more primary, secondary, or tertiary amino groups or nitrogen cation-containing groups and having no perylene diimide ring has excellent nucleic acid delivery efficiency while being a small molecule that can be precisely synthesized.

IPC Classes  ?

• A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
• A61K 31/711 - Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
• A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
• A61K 47/22 - Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
• C07C 217/22 - Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by carbon atoms having at least two bonds to oxygen atoms
• C07C 229/38 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
• C07D 295/037 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements with quaternary ring nitrogen atoms
• C07D 295/155 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/87 - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

Abstract

The main purpose of the present disclosure is to provide a technique capable of exerting an antitumor effect on various types of cancer including malignant melanoma. The present inventors have found that a certain antibody or an antigen-binding fragment thereof can exert an antitumor effect on various types of cancer including malignant melanoma. On the basis of this finding, the present disclosure has been accomplished.

IPC Classes  ?

• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61K 31/20 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid
• A61K 31/4706 - 4-Aminoquinolines8-Aminoquinolines, e.g. chloroquine, primaquine
• A61K 45/00 - Medicinal preparations containing active ingredients not provided for in groups
• A61P 35/00 - Antineoplastic agents
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• C07K 16/40 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against enzymes

Abstract

xyzz (In the formula, x, y, and z represent the number of atoms of Ag, Au, and Te, respectively, and 0.25 ≤ z/(x + y) ≤ 1 holds true. In addition, y/(x + y + z) > 0.10 also holds true.)

IPC Classes  ?

• C01B 19/00 - SeleniumTelluriumCompounds thereof
• B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals
• B82Y 40/00 - Manufacture or treatment of nanostructures

Abstract

The purpose of the present invention is to provide a material that has higher strength and/or bioadhesion after self-repair and is obtained by using an elastin-like polypeptide.　Provided is a composition comprising: a polypeptide that has an amino group and comprises an elastin-like block peptide sequence including a G sequence block comprising (SEQ ID NO: 1:X1GGX2nn (wherein: X1's are the same as or different from each other and each independently represent V or L; X2's are the same as or different from each other and each independently represent V or L; and n represents an integer of 4 or more) and a P sequence block comprising (SEQ ID NO: 2:VPGX3mm (wherein X3's are the same as or different from each other and each independently represent an arbitrary amino acid residue, and m represents an integer of 5 or more); and a water-soluble polymer having an aldehyde group.

IPC Classes  ?

• C08L 101/02 - Compositions of unspecified macromolecular compounds characterised by the presence of specified groups
• A61L 24/00 - Surgical adhesives or cementsAdhesives for colostomy devices
• A61L 24/08 - Polysaccharides
• A61L 24/10 - PolypeptidesProteins
• C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
• C07K 19/00 - Hybrid peptides
• C08L 3/02 - StarchDegradation products thereof, e.g. dextrin
• C08L 5/00 - Compositions of polysaccharides or of their derivatives not provided for in group or
• C08L 77/04 - Polyamides derived from alpha-amino carboxylic acids

Abstract

The present invention pertains to: a surface-modified material that has, on at least of a surface of a zirconium or titanium-containing base material, a surface modification layer containing a zirconium phosphate compound or a titanium phosphate compound; and a method for producing the surface-modified material, the method comprising a step for irradiating a surface of a zirconium or titanium-containing base material with a laser beam to form an antibacterial zirconium compound or an antibacterial titanium compound on said surface.

IPC Classes  ?

• A61K 6/74 - Fillers comprising phosphorus-containing compounds
• A61C 13/08 - Artificial teethMaking same
• A61K 6/58 - Preparations specially adapted for dental root treatment specially adapted for dental implants
• A61K 6/70 - Preparations for dentistry comprising inorganic additives

Abstract

Provided are a device and attachment for transcutaneous electrical stimulation of the second division and/or the third division of the trigeminal nerve, comprising electrodes held on a glasses-shaped frame (2) and an electric circuit for applying electric pulses to the electrode. The device and attachment comprise at least one electrode portion selected from a first electrode portion (31) including at least two electrodes for selectively electrically stimulating the right facial second division, a second electrode portion (32) including at least two electrodes for selectively electrically stimulating the left facial second division, a third electrode portion (33) including at least two electrodes for selectively electrically stimulating the right facial third division, and a fourth electrode portion (34) including at least two electrodes for selectively electrically stimulating the left facial third division. The electric circuit forms a circuit between the at least two electrodes of the first electrode portion (31), forms a circuit between the at least two electrodes of the second electrode portion (32), forms a circuit between the at least two electrodes of the third electrode portion (33), or forms a circuit between the at least two electrodes of the fourth electrode portion (34).

IPC Classes  ?

• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61N 1/04 - Electrodes

Abstract

The present inventors discovered that disease accompanied by osteonecrosis, specifically, femoral head necrosis, prosthesis loosening, and rheumatoid arthritis, can be treated by administration of anti-sclerostin antibody.

IPC Classes  ?

• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
• A61P 19/08 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• C07K 16/22 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors

Abstract

A deformable mirror includes a first substrate having a first surface and a second surface opposite to the first surface and made of a piezoelectric material; a reflecting electrode provided in the first surface and having a reflecting surface on which an X-ray is obliquely incident; a plurality of control electrodes arranged at intervals in a predetermined direction in the second surface; and a power supply structured to apply a voltage between the reflecting electrode and the plurality of control electrodes.

IPC Classes  ?

• G21K 5/10 - Irradiation devices with provision for relative movement of beam source and object to be irradiated
• G21K 5/08 - Holders for targets or for objects to be irradiated
• G21K 7/00 - Gamma ray or X-ray microscopes

Abstract

A synthetic anti-ubiquitin antibody, comprising a fibronectin type III polypeptide monobody.

IPC Classes  ?

• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The present invention addresses the problem of providing a simple information acquisition method for predicting the onset risk of an α-synuclein-related disease including a prodromal phase of Parkinson's disease, a device for use in the method, and a kit including the device.　The problem can be solved by an information acquisition method for predicting the onset risk of an α-synuclein-related disease, the information acquisition method comprising a step for measuring the content of a tubulin polymerization promoting protein contained in a blood sample.

IPC Classes  ?

• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• G01N 33/545 - Synthetic resin