Abstract

The present invention relates to a composition containing a plant extract of the genus Philadelphus as an active ingredient, for the prevention, alleviation, or treatment of tuberculosis. The plant extract of the genus Philadelphus significantly reduces the number of Mycobacterium tuberculosis in (in vivo samples of) mice as well as macrophages derived from mouse bone marrow infected with Mycobacterium tuberculosis, and exhibits synergistic effects on the reduction of Mycobacterium tuberculosis when co-administered with an antituberculosis agent, and thus the plant extract of the genus Philadelphus of present invention may be usefully employed as an antituberculosis agent.

IPC Classes  ?

• A61K 36/185 - Magnoliopsida (dicotyledons)
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61P 31/06 - Antibacterial agents for tuberculosis
• A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives
• A23K 10/30 - Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hayAnimal feeding-stuffs from material of fungal origin, e.g. mushrooms

Abstract

The present invention relates to a hemostatic balloon catheter for a bronchoscope, which is stably fixed to a bronchus as a preventive measure against the possibility of massive bleeding in the bronchus during a bronchoscopic procedure and can immediately stop the bleeding at a precise location when bleeding occurs. More specifically, the present invention relates to a balloon catheter for bronchial hemostasis, characterized in that an anchoring balloon is formed at a distal end inserted into the body and one or more hemostatic balloons are formed at a predetermined distance from the anchoring balloon.

IPC Classes  ?

• A61B 17/12 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
• A61M 25/10 - Balloon catheters
• A61B 17/00 - Surgical instruments, devices or methods

Abstract

Provided is a method for providing the information for diagnosing nonalcoholic steatohepatitis.

IPC Classes  ?

• A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
• A61B 6/03 - Computed tomography [CT]
• A61B 6/46 - Arrangements for interfacing with the operator or the patient

Abstract

The present invention relates to novel biomarkers for diagnosing and predicting the prognosis of cholangiocarcinoma, and use thereof. More specifically, the present invention provides a method for the diagnosis, prognosis prediction and treatment of cholangiocarcinoma by using, as biomarkers, changes in the level of fucosylation and the sugar chain structure of serum-derived exosomes of cholangiocarcinoma patients. The biomarkers of the present invention exhibit excellent specificity and sensitivity for cholangiocarcinoma so as to be used in methods for diagnosis, prognosis prediction and treatment of cholangiocarcinoma patients, and thus can contribute to increasing the treatment efficiency of cholangiocarcinoma patients and reducing mortality from cholangiocarcinoma.

IPC Classes  ?

• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The present invention provides an air aspiration prevention device comprising: a catheter (10) including an insertion tube (11) to be inserted in a subject in which the catheter is to be inserted, and a hub body (12) having a plurality of connectors (13); and an air aspiration prevention module (100) provided in the insertion tube (11) of the catheter (10), wherein the air aspiration prevention module (100) includes: a body (110) having a first insertion hole (111) in which the insertion tube (11) is inserted so as to pass therethrough; a syringe connector (112) communicating with the first insertion hole (111); and an extension part (120) which is connected to the body (110) so as to communicate with the first insertion hole (111) of the body (110), and which has a second insertion hole (121) in which the insertion tube (11) is inserted so as to pass therethrough, and the extension part (120) has an adjustable length from the body (110), and thus air aspiration, when the catheter (10) is removed from the subject in which the catheter is to be inserted, into the body of the subject in which the catheter is to be inserted can be prevented.

IPC Classes  ?

• A61M 25/00 - CathetersHollow probes
• A61M 25/02 - Holding devices, e.g. on the body

Abstract

The present invention relates to a novel method for preparing an organoid, that addresses the issue of low organoid generation rate by enzymatic treatment by replacing the enzymatic cell dissociation for organoid preparation in the conventional art with physical dissociation and, more specifically, to a method for preparing an organoid, comprising the steps of: (A) rapidly freezing biological tissue; (B) thawing the rapidly frozen sample; (C) mechanically dissociating the thawed sample to obtain dissociated cells; and (D) preparing an organoid by using the dissociated cells.

IPC Classes  ?

• C12N 5/09 - Tumour cells
• A01N 1/02 - Preservation of living parts

Abstract

A method for predicting an anticoagulant prescription dose implemented by a processor, according to one embodiment, may comprise the steps of: receiving clinic data of a patient; generating input data on the basis of the clinic data; by applying the input data to a first machine learning model comprising sub-machine learning models corresponding to each of a plurality of prescription dose intervals in which an expected prescription range of an anticoagulant is divided into unit doses, outputting a plurality of prediction results for the plurality of prescription dose sections; and predicting an anticoagulant prescription dose for the patient on the basis of the outputted plurality of prediction results.

IPC Classes  ?

• G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
• G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
• G16H 10/00 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data
• G16H 70/00 - ICT specially adapted for the handling or processing of medical references
• G06N 20/00 - Machine learning

Abstract

The present invention relates to a pneumatic distractor for orthopedic surgery. The pneumatic distractor can use air pressure to facilitate fixing during distraction and fracture reduction, thus making it easy to perform three-dimensional fracture reduction by rotating a ball joint, and immediately fixing a fracture once the fracture has been reduced.

IPC Classes  ?

• A61B 17/60 - Surgical instruments or methods for treatment of bones or jointsDevices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements for external osteosynthesis, e.g. distractors or contractors
• A61B 17/00 - Surgical instruments, devices or methods

Abstract

The present invention relates to an arterial cannula and an ECMO cannula set comprising same, and more particularly, to an arterial cannula having two or more blood flows in a single catheter and an ECMO cannula set comprising same. The arterial cannula according to one embodiment of the present invention may comprise: a catheter that is inserted into the body; a graspable main body in fluid communication with the catheter; and an auxiliary lumen having an outlet on the outer surface of the catheter and an inlet on the outer surface of the main body. The present invention has the advantage that blood flow to the distal parts can be generated using the structure of an existing arterial cannula.

IPC Classes  ?

• A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
• A61M 25/00 - CathetersHollow probes

Abstract

The present invention relates to a method for detecting Mycobacterium tuberculosis, which can replace the conventional culture method that takes a long time of four to eight weeks to detect active tuberculosis, and which is a method for detecting active Mycobacterium tuberculosis by using isotopes on a sample of a patient's sputum or bronchoalveolar lavage fluid.

IPC Classes  ?

• C12Q 1/16 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor using radioactive material
• C12Q 1/58 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving urea or urease

Abstract

Provided are a composition for treating or preventing recurrence of keloid comprising tauroursodeoxycholic acid as an active ingredient, and a method for treating keloid or preventing recurrence of keloid using the composition.

IPC Classes  ?

• A61K 31/575 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
• A61K 8/46 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/06 - OintmentsBases therefor
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Abstract

A surgical polygonal locking screw removal device includes: a body including a passage part in which a passage having a preset diameter is formed, and a polygonal expansion part configured to be coupled to a polygonal groove formed in a surgical locking screw to remove the surgical locking screw, the polygonal expansion part protruding from a leading end of the passage part; and a handle configured to be inserted into a rear end of the passage part and screw-coupled to the passage part, and configured to expand the polygonal expansion part.

IPC Classes  ?

• A61B 17/92 - Impactors or extractors, e.g. for removing intramedullary devices
• A61B 17/88 - Methods or means for implanting or extracting internal fixation devices
• A61B 17/90 - Guides therefor

Abstract

The present invention relates to a drainage tube having a novel expandable fixing structure not requiring to be fixed to skin, the drainage tube comprising: an expandable fixing part which surrounds the part of the drainage tube that, when inserted, becomes positioned inside the body near the skin, and which expands due to a fluid supplied from the outside; and a fluid channel the distal part of which is connected to the inside of the expandable fixing part in order to supply and discharge the fluid to the expandable fixing part, and the proximal part of which comprises a fluid supply tube that is exposed to the outside of the body when the drainage tube is inserted. According to the drainage tube of the present invention, the drainage tube adheres and is fixed to the inside of the body due to the expansion of the expandable fixing part inserted into the body, and, thus, a drainage tube operation and collection can be easily performed without any separate fixing member and without causing any additional would besides a minimal hole for the insertion of the drainage tube.

IPC Classes  ?

• A61M 25/04 - Holding devices, e.g. on the body in the body, e.g. expansible
• A61M 27/00 - Drainage appliances for wounds, or the like
• A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
• A61M 25/10 - Balloon catheters
• A61M 25/02 - Holding devices, e.g. on the body

Abstract

A wound dressing patch includes a backing film; an absorbent foam pad coupled to the a portion of one surface of the backing film; an adhesive sheet provided on a remaining portion of the one surface of the backing film; and a lining material provided along a peripheral edge portion of the adhesive sheet and configured to impart a predetermined stiffness to the backing film. The lining material is spaced apart from the absorbent foam pad to surround the absorbent foam pad in a form of a substantially closed curve along the peripheral edge portion of the adhesive sheet, and a distance between the lining material and an end of the adhesive sheet is shorter than a distance between the lining material and an edge of the absorbent foam pad.

IPC Classes  ?

• A61F 13/02 - Adhesive bandages or dressings
• A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials

Abstract

An auxiliary device for use in a trocar instrument, including a trocar needle having a fastening groove formed on an outer circumferential surface thereof. The auxiliary device includes: a body into which at least a portion of the trocar needle is inserted; and a hook connected to the body and configured to be inserted into the fastening groove of the trocar needle. The hook includes a fixing portion fixed to the body and a coupling portion extending from one end of the fixing portion and configured to be inserted into the fastening groove when the trocar needle is disposed inside the body. A gap is formed between the fixing portion and the coupling portion.

IPC Classes  ?

• A61B 17/34 - TrocarsPuncturing needles

Abstract

Disclosed is an apparatus for measuring the distribution of radiation dose emitted from a brachytherapy insertion tool, the apparatus including a housing having defined therein a measurement space in which the brachytherapy insertion tool is located, a fluorescent member disposed at the housing, the fluorescent member being configured to react with radiation emitted to the measurement space and to emit light, a camera disposed in the housing, and a cover coupled to one surface of the housing, the cover being configured to cover the fluorescent member. The portion of the fluorescent member to which radiation from a radiation source of the brachytherapy insertion tool is applied reacts with the radiation and generates light, brightness of the light varies depending on distribution of the radiation, and the position at which the light is bright is calculated to measure the direction in which the brachytherapy insertion tool has no shielding.

IPC Classes  ?

• G01T 1/10 - Luminescent dosimeters
• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy
• G01T 1/161 - Applications in the field of nuclear medicine, e.g. in vivo counting
• G01T 1/29 - Measurement performed on radiation beams, e.g. position or section of the beamMeasurement of spatial distribution of radiation
• G01T 7/00 - Details of radiation-measuring instruments

Abstract

The present invention relates to an experimental animal managing method. Disclosed is an experimental animal managing method comprising: a receiving step (S10) of receiving user log data and individual data of an experimental animal; and a processing step (S20) of calculating at least one of an expected production amount of individuals, the expected number of cages to be produced, and the expected total number of cages, on the basis of the user log data and the individual data, and optimizing at least one among the calculated expected production amount of individuals, the calculated expected number of cages to be produced, and the calculated expected total number of cages according to optimization requirement.

IPC Classes  ?

• A01K 67/02 - Breeding vertebrates
• G06N 3/08 - Learning methods

Abstract

The present invention relates to human thyroid cells and an isolation method therefor, the cells having a survival rate of 90% or higher and being usable in novel human thyroid research including single cell genomics, single cell metabolomics and organoid preparation.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor

Abstract

The present invention relates to a method for detecting Mycobacterium tuberculosis, which can replace the conventional culture method that takes a long time of four to eight weeks to detect active tuberculosis, and which is a method for detecting active Mycobacterium tuberculosis by using isotopes on a sample of a patient's sputum or bronchoalveolar lavage fluid.

IPC Classes  ?

• C12Q 1/16 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor using radioactive material
• C12Q 1/58 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving urea or urease

Abstract

The present invention relates to a gas removing kit, and a gas removing device comprising same and, more specifically, to a gas removing kit which expels gas in the thorax, and a gas removing device comprising same. Disclosed is a gas expelling kit comprising: a catheter (100) comprising an insertion part (110) which is inserted into the body so as to expel gas accommodated in the body to the outside of the body, and a flexible part (120) which extends from the insertion part (110) and is exposed to the outside of the body, wherein the catheter (100) has therein a flow path (S) through which the gas flows; and a main body part (200) having one end to which the catheter (100) is coupled, and the other end at which a discharge port (210) is formed, so as to expel the gas, which is introduced therein through the flow path (S), to the outside. The flexible part (120) is bent such that the longitudinal direction of the main body part (200) is changed from a direction parallel to the direction in which the catheter (100) is inserted into the body to a direction that intersects the direction in which the catheter (100) is inserted into the body.

IPC Classes  ?

• A61M 1/04 - Pneumothorax apparatus
• A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
• A61M 25/06 - Body-piercing guide needles or the like
• A61M 25/02 - Holding devices, e.g. on the body
• A61B 17/34 - TrocarsPuncturing needles

Abstract

According to the present invention, polydopamine can convert a hydrophobic surface to a hydrophilic surface, and can modify various surfaces regardless of the surface properties. The polydopamine coated on the surface can form a covalent bond with an amine group and a thiol group, and secondarily modify the surface by coordinate bonding with various metals. Utilizing this versatility increases the bonding of the polydopamine with silica and DNA, and the polydopamine can also be utilized as an adsorbent.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

Disclosed is an apparatus for removing a surgical polygonal locking screw. According to one embodiment of the present invention, an apparatus for removing a surgical polygonal locking screw may be provided, the apparatus comprising: a body comprising a passage part which has a passage having a predetermined diameter formed therein, and a polygonal expansion part which is coupled to a polygonal groove formed in a surgical locking screw, and protrudes from the front end of the passage part so as to remove the locking screw; and a handle inserted in the rear end of the passage part and screw-coupled to the passage part, and configured so as to expand the polygonal expansion part.

IPC Classes  ?

• A61B 17/92 - Impactors or extractors, e.g. for removing intramedullary devices
• A61B 17/88 - Methods or means for implanting or extracting internal fixation devices
• A61B 17/90 - Guides therefor

Abstract

A wound dressing patch according to an embodiment of the present invention may include: a backing film; an absorbent foam pad coupled to a portion of the one surface of the backing film; an adhesive sheet provided on the remaining portions of the one surface of the backing film; and a lining material provided along a peripheral edge portion of the adhesive sheet and imparting a certain degree of rigidity to the backing film. Also, the lining material is spaced apart from the absorbent foam pad and forms a substantially closed curve along the peripheral edge portion of the adhesive sheet while covering the surroundings of the absorbent foam pad, and the distance between the lining material and the end of the adhesive sheet may be shorter than the distance between the lining material and the edge of the absorbent foam pad.

IPC Classes  ?

• A61F 13/02 - Adhesive bandages or dressings
• A61L 15/22 - Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
• A61F 13/00 - Bandages or dressingsAbsorbent pads

Abstract

Provided is an assistant device used for a trocar device which comprises a trocar needle having a coupling groove in an outer circumferential surface thereof. The assistant device comprises: a body in which at least a portion of the trocar needle is inserted; and a hook which is connected to the body and can be inserted into the coupling groove of the trocar needle. The hook comprises: a fixing portion which is fixed to the body; and a coupling portion which extends from one end of the fixing portion and is inserted into the coupling groove when the trocar needle is disposed inside the body, wherein a gap is provided between the fixing portion and the coupling portion.

IPC Classes  ?

• A61B 17/34 - TrocarsPuncturing needles
• A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
• A61B 17/00 - Surgical instruments, devices or methods

Abstract

The present invention measures the dose distribution of radiation discharged from an insertion tool for radiation brachytherapy, and includes: a housing having, formed therein, a measurement space in which the insertion tool for radiation brachytherapy is positioned; a fluorescent member which is disposed in the housing and emits light upon reacting with the radiation discharged into the measurement space; a camera disposed in the housing; and a cover coupled to one surface of the housing and covering the fluorescent member. A fluorescent member portion, which is irradiated with the radiation radiated from a radiation source of the insertion tool for radiation brachytherapy, generates light upon reacting with the radiation, and the brightness of the light varies according to the distribution of the radiation. Thus, the positions at which the light is bright are calculated to measure the direction in which the insertion tool for radiation brachytherapy does not have shielding.

IPC Classes  ?

• G01T 1/29 - Measurement performed on radiation beams, e.g. position or section of the beamMeasurement of spatial distribution of radiation
• G01T 1/161 - Applications in the field of nuclear medicine, e.g. in vivo counting
• G01T 7/00 - Details of radiation-measuring instruments
• G01T 1/10 - Luminescent dosimeters
• G01D 11/24 - Housings