Abstract

The present invention relates to the field of pharmaceutical chemistry, and in particular to a new aryl urea derivative, namely a compound of general formula I, or a pharmaceutically acceptable salt, solvate or prodrug thereof, a pharmaceutical composition comprising the compound, and the use thereof, wherein substituents R1, R2, R3and R4, X, Y, Z, m and n have the significances given in the description. The present invention further relates to the use of the compound of general formula I in the preparation of a drug for treating and/or preventing sEH-mediated diseases, and in particular in the preparation of a drug for treating inflammatory diseases, cardiovascular and cerebrovascular diseases, pain, diabetes, complications of diabetes, diabetes-related diseases, fibrotic diseases, neurological and psychiatric diseases, ulcerative diseases, etc.

IPC Classes  ?

• C07D 417/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 277/82 - Nitrogen atoms
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61K 31/428 - Thiazoles condensed with carbocyclic rings
• A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
• A61K 31/541 - Non-condensed thiazines containing further heterocyclic rings
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• A61P 25/00 - Drugs for disorders of the nervous system

Abstract

Provided is a method for preparing cyclosulfonone, which is characterized by comprising any one of the following steps.

IPC Classes  ?

• C07C 319/20 - Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
• C07C 15/04 - Benzene
• C07C 317/24 - SulfonesSulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
• C07C 315/04 - Preparation of sulfonesPreparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups

Abstract

1212321322232122321323213231233−.

IPC Classes  ?

• C07C 319/20 - Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
• C07D 231/20 - One oxygen atom attached in position 3 or 5
• C07D 405/14 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
• A01N 43/56 - 1,2-DiazolesHydrogenated 1,2-diazoles
• A01P 13/00 - HerbicidesAlgicides

Abstract

A current-type inverter input-series output-parallel photovoltaic power generation system, comprising: a direct-current side photovoltaic cell, an alternating-current side power supply, and a plurality of single-phase current source inverter modules. Input ends of the plurality of single-phase current source inverter modules are connected in series and then are connected to the direct-current side photovoltaic cell. Output ends of the plurality of single-phase current source inverter modules are connected in parallel and then are connected to the alternating-current side power supply. The photovoltaic power generation system is formed by combining the plurality of single-phase current source inverter modules, forming a single-stage grid-connected inverter modularly combined system, so that the capacity of grid-connected inverters is improved, and the voltage stress and current stress borne by each inverter are reduced, thereby improving the reliability of the system. Additionally, the system can realize multi-level grid-connected current output, and achieves the effect of reducing the total harmonic content of a grid-connected current, so that the size of an alternating-current side filter is reduced.

IPC Classes  ?

• H02J 3/38 - Arrangements for parallelly feeding a single network by two or more generators, converters or transformers
• H02J 3/01 - Arrangements for reducing harmonics or ripples
• H02M 7/493 - Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode the static converters being arranged for operation in parallel
• H02M 7/5395 - Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters with automatic control of output wave form or frequency by pulse-width modulation
• H02M 1/00 - Details of apparatus for conversion

Abstract

Disclosed in the present invention are a light-load operation control system and method for a three-phase CLLLC resonant converter. The light-load operation control system comprises: a PI regulator module, a VCO module, a comparison module, a phase shift module and a mode switching module; the PI regulator module is used for generating a required frequency and phase shift angle; the VCO module is used for generating a sine wave of the required frequency; the comparison module is used for outputting a rectangular wave pulse of the required frequency on the basis of the sine wave; the phase shift module is used for generating a rectangular wave pulse of the required phase shift angle; and the mode switching module is used for completing control mode switching on the basis of the rectangular wave pulse of the required frequency and the rectangular wave pulse of the required phase shift angle. Under a normal operating condition, the conduction loss can be reduced, and the efficiency is higher. Under a light load condition, one phase is cut off to realize a similar two-phase full-bridge structure, so that the switching loss and the loss generated by a circulating current are reduced, and the light load efficiency is improved. By means of two-phase phase shift control, the voltage gain range is widened, the switching frequency required for realizing a wide voltage gain requirement is reduced, and the switching loss is reduced.

IPC Classes  ?

• H02M 3/335 - Conversion of DC power input into DC power output with intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate AC using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only
• H02M 3/00 - Conversion of DC power input into DC power output
• H02M 1/00 - Details of apparatus for conversion

Abstract

Provided in the present invention are a method and apparatus for grading scrap preheating, and an electronic device and a storage medium. The method comprises: on the basis of a predetermined scrap classification standard, dividing into M grades scrap raw materials to be processed; on the basis of preset restriction conditions of the scrap raw material of each grade, determining the addition amount of the scrap raw material of each grade according to a preset objective function, wherein the preset restriction conditions are constructed according to attribute parameters of the scrap raw material of each grade, and the preset objective function is determined according to a specific surface area coefficient of the scrap raw material of each grade; according to the addition amount of the scrap raw material of each grade, determining N distribution manners of the scrap raw material of each grade in a scrap preheating apparatus; calculating a preheating temperature of the scrap raw material of each grade in each distribution manner, and determining an optimal distribution manner according to the preheating temperature of the scrap raw material of each grade in each distribution manner. By means of the present invention, scrap preheating efficiency can be improved, thereby reducing the power consumption.

IPC Classes  ?

• G06F 30/20 - Design optimisation, verification or simulation

Abstract

A compound represented by general formula (I) or stereoisomers thereof and pharmaceutically acceptable salts, solvates or prodrugs thereof, a preparation method therefor and a pharmaceutical composition containing the compound. An application of the compound of general formula (I) in preparation of drugs for treating and/or preventing she-mediated diseases, especially an application in preparation of drugs for treating inflammatory diseases, cardiovascular and cerebrovascular diseases, diabetes, diabetes complications, diabetes-related diseases, fibrotic diseases, neurological and mental diseases, pain, and ulcer diseases, etc. A compound represented by general formula (I) or stereoisomers thereof and pharmaceutically acceptable salts, solvates or prodrugs thereof, a preparation method therefor and a pharmaceutical composition containing the compound. An application of the compound of general formula (I) in preparation of drugs for treating and/or preventing she-mediated diseases, especially an application in preparation of drugs for treating inflammatory diseases, cardiovascular and cerebrovascular diseases, diabetes, diabetes complications, diabetes-related diseases, fibrotic diseases, neurological and mental diseases, pain, and ulcer diseases, etc.

IPC Classes  ?

• C07D 277/82 - Nitrogen atoms
• C07D 513/04 - Ortho-condensed systems
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
• A61P 27/02 - Ophthalmic agents
• A61P 25/04 - Centrally acting analgesics, e.g. opioids
• A61P 25/24 - Antidepressants

Abstract

Disclosed are an alumina-based heterojunction material with abundant oxygen vacancies and a preparation method thereof. The heterojunction material is composed of alumina with abundant oxygen vacancies and bismuth-rich bismuth oxychloride. The method includes mixing aluminum nitrate nonahydrate, bismuth nitrate pentahydrate, an ammonium salt and urea, each in certain amount, under stirring to obtain a mixture B, placing the mixture B in a muffle furnace, heating the mixture B and continuing the stirring to gradually melt the mixture B to form an ionic liquid B; and subjecting the ionic liquid B to a spontaneous combustion reaction in the muffle furnace to obtain a product B, and cooling the product B to room temperature to obtain the alumina-based heterojunction material with abundant oxygen vacancies.

IPC Classes  ?

• C01F 7/308 - Thermal decomposition of nitrates
• C01G 29/00 - Compounds of bismuth
• H01L 29/24 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only inorganic semiconductor materials not provided for in groups , ,  or

Abstract

The present disclosure discloses a method for modulating a switch of a converter. The method is applicable to a topological structure of a multiphase stacked interleaved buck converter, and includes: acquiring charge-discharge state information in the topological structure, wherein the charge-discharge state information comprises at least a first charge-discharge state of any one phase primary loop, a second charge-discharge state of a secondary loop corresponding to the any one phase primary loop, a third charge-discharge state of another primary loop, and a fourth charge-discharge state of another secondary loop; and adjusting, based on the first charge-discharge state, a closed state of a switch disposed on a bridge arm connected to the any one phase primary loop, and adjusting, based on the second charge-discharge state and the third charge-discharge state, a closed state of a switch disposed on another bridge arm.

IPC Classes  ?

• H02M 3/158 - Conversion of DC power input into DC power output without intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only with automatic control of output voltage or current, e.g. switching regulators including plural semiconductor devices as final control devices for a single load
• H02M 1/14 - Arrangements for reducing ripples from DC input or output
• H02M 1/088 - Circuits specially adapted for the generation of control voltages for semiconductor devices incorporated in static converters for the simultaneous control of series or parallel connected semiconductor devices

Abstract

A circuit system for weight modulation and image recognition of a memristor array includes a personal computer (PC), a field-programmable gate array (FPGA) chip, a digital-to-analog conversion unit, a switch unit, a memristor array unit, an integration and signal amplification circuit, and an analog-to-digital converter. The circuit system selects a to-be-realized function such as array reading and writing, weight modulation or image recognition, converts a command or an RGB value of an image collected by the PC into a corresponding grayscale value, and sends the grayscale value to the FPGA chip. The FPGA chip controls and selects a to-be-modulated memristor array unit through the digital-to-analog conversion unit and the switch unit. An application program of the PC controls the FPGA chip in real time to realize array reading and writing, weight modulation, and image recognition, and then the FPGA chip displays a result on the PC in real time.

IPC Classes  ?

• H03M 1/00 - Analogue/digital conversionDigital/analogue conversion
• H03M 1/46 - Analogue value compared with reference values sequentially only, e.g. successive approximation type with digital/analogue converter for supplying reference values to converter
• H03M 1/12 - Analogue/digital converters
• H03M 1/66 - Digital/analogue converters

Abstract

3 can reach 40 nm.

IPC Classes  ?

• C23C 14/08 - Oxides
• H10N 70/00 - Solid-state devices having no potential barriers, and specially adapted for rectifying, amplifying, oscillating or switching

Abstract

The present application belongs to the field of electrical steel fabrication, and provides a strongly magnetic oriented high-silicon steel ultrathin strip and a preparation method therefor. The strongly magnetic oriented high-silicon steel ultrathin strip comprises the following elements in percentage by mass: 0.0045 to 0.0060% C; 4.5% to 5.0% Si; 0.23% to 0.32% Mn; 0.02% to 0.03% S; 0.03% to 0.08% Bi; 0.027% to 0.035% Als; 0.02% to 0.03% Cu; 0.008% to 0.010% N; P<0.005%; and the remainder is iron, wherein the Cu, S and N elements are added into a strongly magnetic oriented high-silicon steel ultrathin strip in the form of a polynuclear coordination compound containing sulfur, nitrogen and copper during smelting. In the present application, by means of designing the raw material components of oriented high-silicon steel, and using the polynuclear coordination compound containing sulfur, nitrogen and copper, and a Bi element as alloy inhibitors, the prepared strongly magnetic oriented high-silicon steel ultrathin strip has fine grains, a uniform structure, and excellent magnetic properties having high magnetic induction intensity and low iron loss.

IPC Classes  ?

• C22C 38/02 - Ferrous alloys, e.g. steel alloys containing silicon
• C22C 38/04 - Ferrous alloys, e.g. steel alloys containing manganese
• C22C 38/06 - Ferrous alloys, e.g. steel alloys containing aluminium
• C22C 38/16 - Ferrous alloys, e.g. steel alloys containing copper
• C21D 1/26 - Methods of annealing
• C21D 1/773 - Methods of treatment in inert gas, controlled atmosphere, vacuum or pulverulent material under reduced pressure or vacuum
• C21D 1/74 - Methods of treatment in inert gas, controlled atmosphere, vacuum or pulverulent material
• C21D 1/70 - Temporary coatings or embedding materials applied before or during heat treatment while heating or quenching
• C21D 8/12 - Modifying the physical properties by deformation combined with, or followed by, heat treatment during manufacturing of articles with special electromagnetic properties

Abstract

Thiobacillus denitrificans. The embedding agent includes a poly(vinyl alcohol)-sodium alginate blend membrane and a crosslinked composite membrane. The embedded complex is embedded by the embedded agent.

IPC Classes  ?

• C02F 3/34 - Biological treatment of water, waste water, or sewage characterised by the microorganisms used
• C02F 3/30 - Aerobic and anaerobic processes
• C02F 3/32 - Biological treatment of water, waste water, or sewage characterised by the animals or plants used, e.g. algae
• C12N 11/08 - Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a synthetic polymer
• C02F 101/16 - Nitrogen compounds, e.g. ammonia
• C02F 3/00 - Biological treatment of water, waste water, or sewage
• C12N 11/084 - Polymers containing vinyl alcohol units

Abstract

Penicillium oxalicum SDF-25 strain can secrete a large amount of carboxymethyl cellulase at 10 to 16° C., and still produce enzyme at 6° C. The highest enzymatic activity can reach 993.3 U/mL.

IPC Classes  ?

• C12N 1/14 - Fungi Culture media therefor
• C05F 17/20 - Preparation of fertilisers characterised by biological or biochemical treatment steps, e.g. composting or fermentation using specific microorganisms or substances, e.g. enzymes, for activating or stimulating the treatment
• C12R 1/80 - Penicillium

Abstract

A Bacillus subtilis BS40-4 strain is deposited in China General Microbiological Culture Collection Center (CGMCC) with an accession number CGMCC No. 19757.

IPC Classes  ?

• C05F 17/20 - Preparation of fertilisers characterised by biological or biochemical treatment steps, e.g. composting or fermentation using specific microorganisms or substances, e.g. enzymes, for activating or stimulating the treatment
• C12N 1/20 - BacteriaCulture media therefor
• C12N 11/10 - Enzymes or microbial cells immobilised on or in an organic carrier the carrier being a carbohydrate
• C12N 11/14 - Enzymes or microbial cells immobilised on or in an inorganic carrier

Abstract

A device for treatment of organic waste includes a heating unit, a hydrolysis tank, a regulating tank, an aerobic fermentation reactor, an organic waste feeder, an aerobe feeder, a delivery mechanism, a deodorization unit, and an air distributor. The hydrolysis tank is connected to the regulating tank, and the regulating tank is connected to the aerobic fermentation reactor. The delivery mechanism is disposed between the regulating tank and the aerobic fermentation reactor. The heating unit is connected to the hydrolysis tank and is configured to heat an organic material in the hydrolysis tank. The organic waste feeder and the aerobe feeder are connected to the regulating tank. The deodorization unit is disposed on and connected to the aerobic fermentation reactor. The air distributor is disposed in the aerobic fermentation reactor and is configured to provide oxygen to the aerobic fermentation reactor.

IPC Classes  ?

• C02F 9/00 - Multistage treatment of water, waste water or sewage
• C02F 1/02 - Treatment of water, waste water, or sewage by heating
• C02F 101/30 - Organic compounds

Abstract

A compound represented by general formula (I) or stereisomers thereof and pharmaceutically acceptable salts, solvates or prodrugs thereof, a preparation method therefor and a pharmaceutical composition containing the compound. An application of the compound of general formula (I) in preparation of drugs for treating and/or preventing she-mediated diseases, especially an application in preparation of drugs for treating inflammatory diseases, cardiovascular and cerebrovascular diseases, diabetes, diabetes complications, diabetes-related diseases, fibrotic diseases, neurological and mental diseases, pain, and ulcer diseases, etc.

IPC Classes  ?

• C07D 277/82 - Nitrogen atoms
• C07D 417/12 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a chain containing hetero atoms as chain links
• C07D 513/04 - Ortho-condensed systems
• A61K 31/5377 - 1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
• A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 9/00 - Drugs for disorders of the cardiovascular system
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
• A61P 25/18 - Antipsychotics, i.e. neurolepticsDrugs for mania or schizophrenia
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 1/04 - Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• A61P 27/02 - Ophthalmic agents

Abstract

Provided are a penicillium oxalicum SDF-25 strain and the use thereof. The penicillium oxalicum SDF-25 strain has the deposit number of CGMCC No.19272, and penicillium oxalicum SDF-25 can be used for degrading straws. The penicillium oxalicum SDF-25 strain can grow normally at a temperature of 6°C-37°C, can secrete a large amount of carboxymethyl cellulase at a temperature of 10°C-16°C, and can still produce an enzyme at a low temperature of 6°C, wherein the activity of the enzyme can reach up to 993.3 U/mL.

IPC Classes  ?

• C12N 1/14 - Fungi Culture media therefor
• C05F 11/00 - Other organic fertilisers
• C05F 17/20 - Preparation of fertilisers characterised by biological or biochemical treatment steps, e.g. composting or fermentation using specific microorganisms or substances, e.g. enzymes, for activating or stimulating the treatment
• C12R 1/80 - Penicillium

Abstract

2 material. The neuro-bionic device of the present invention is prepared by an evaporating coating method and a drop-coating method. The preparation process is relatively simple. The prepared device can successfully simulate the characteristics of synapse. More importantly, the resistance of the device can be modulated continuously under a scanning of a pulse sequence with pulse width and interval of 10 ns, which is beneficial to the application of the device in the ultrafast synapse simulation.

IPC Classes  ?

• B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals
• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
• C23C 16/50 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating using electric discharges
• B82Y 10/00 - Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
• G06N 3/06 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons
• G11C 11/54 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using elements simulating biological cells, e.g. neuron
• G06N 3/04 - Architecture, e.g. interconnection topology

Abstract

The present application provides methods, compositions, and kits for transfecting a single-stranded DNA into a cell. Further provided are methods and compositions for modifying a target nucleic acid in a cell using a DNA-guided nuclease (such as an Argonaute) and a single-stranded guide DNA.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• C12N 15/55 - Hydrolases (3)
• C12N 9/22 - Ribonucleases
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression

Abstract

Provided is a method for preparing a single crystal of an anhydrous halogenated choline or a derivative thereof, comprising the steps of: (1) proportionally weighing the halogenated choline or a derivative thereof, an alcohol or ether compound or a mixture of an alcohol or ether compound and a polyol; (2) placing the alcohol or ether compound or the mixture of the alcohol or ether compound and the polyol in a reactor, heating to 70-90 DEG C, adding the halogenated choline or derivative thereof and reacting thermostatically until a uniform and transparent eutectic solvent is formed; (3) colling programmedly the eutectic solvent to 15 DEG C and keeping at 15 DEG C to age C for a certain time until no further single crystal is precipitated; (4) filtering, washing and drying under reduced vacuum to obtain the single crystals of the anhydrous halogenated choline or the derivative thereof. The product has good light and heat stability, high moisture, deliquescence or caking resistance, is easily operable, and has non-volatile, less polluting and recycled solvents.

IPC Classes  ?

• C07C 215/40 - Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton with quaternised nitrogen atoms bound to carbon atoms of the carbon skeleton
• C07C 213/10 - SeparationPurificationStabilisationUse of additives

Abstract

A multi-function cooling and thermo-sensitive rack includes horizontal bars, a base, positioning holes, connectors, a lateral frame, connecting holes, a temperature-displaying prompter, and N temperature sensors. The lateral frame and the base are connected through the connectors. The lateral frame and the base have their surfaces facing each other symmetrically provided with plural connecting holes thereon. The horizontal bars have two ends thereof received in the corresponding symmetrical connecting holes. The positioning holes are distributed over the surface of the base. The N temperature sensors have output ends thereof for outputting sensing signals connected with input ends of the temperature-displaying prompter for inputting the N temperature-sensing signals. The present invention is applied to apparatuses used in microbiology experiment.

IPC Classes  ?

• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• B01L 9/06 - Test-tube standsTest-tube holders

Abstract

A multi-function cooling and thermo-sensitive rack includes horizontal bars, a base, positioning holes, connectors, a lateral frame, connecting holes, a temperature-displaying prompter, and N temperature sensors. The lateral frame and the base are connected through the connectors. The lateral frame and the base have their surfaces facing each other symmetrically provided with plural connecting holes thereon. The horizontal bars have two ends thereof received in the corresponding symmetrical connecting holes. The positioning holes are distributed over the surface of the base. The N temperature sensors have output ends thereof for outputting sensing signals connected with input ends of the temperature-displaying prompter for inputting the N temperature-sensing signals. The present invention is applied to apparatuses used in microbiology experiment.

IPC Classes  ?

• B01L 9/06 - Test-tube standsTest-tube holders
• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters

Abstract

Provided is a surface passivation technique for a silicon wafer (1). By preparing a polystyrene sulfonic acid thin film (2) on the surface of a silicon wafer (1), passivation of the surface of the silicon wafer (1) is realized. The thickness of the polystyrene sulfonic acid thin film (2) prepared on the surface of the silicon wafer (1) is on the nano scale. After passivation of the surface of the silicon wafer (1) by the polystyrene sulfonic acid thin film (2), a high-quality passivation effect can be obtained, and the minority carrier lifetime can reach more than 20 ms. Besides this, the preparation of the polystyrene sulfonic acid thin film (2) can be realized by a spin-coating method, a spraying coating method or a printing method, etc., and the passivation technique has a simple process without requiring a vacuum or a high temperature, and is safe and convenient to operate. The provided passivation technique has a very important application value for silicon material detection and silicon solar energy cell surface passivation.

IPC Classes  ?

• H01L 31/18 - Processes or apparatus specially adapted for the manufacture or treatment of these devices or of parts thereof

Abstract

The present application provides methods, compositions, delivery systems, and kits for modifying a target nucleic acid using an Argonaute (Ago) and a single-stranded guide DNA. In some embodiments, methods of gene editing in a cell, such as a mammalian cell, are provided.

IPC Classes  ?

• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12N 15/85 - Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
• C12N 15/86 - Viral vectors
• C12N 15/55 - Hydrolases (3)
• C12N 9/22 - Ribonucleases
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

Abstract

Disclosed in the present invention is a protein tyrosine phosphatase inhibitor. The preparation method therefor is: extracting the crude product from the Isaria Fumosorosea Wize solid or liquid fermentation broth using ethyl acetate, ethanol, methanol, or a mixed solvent of chloroform and methanol; separating the obtained extract using column chromatography on silica gel; and obtaining the target product. The inhibitor can be used to prepare pharmaceutical compositions for treating and preventing diabetes, obesity and cancers.

IPC Classes  ?

• A61K 31/4412 - Non-condensed pyridinesHydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
• A61K 9/19 - Particulate form, e.g. powders lyophilised
• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/20 - Pills, lozenges or tablets
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• C07D 213/89 - Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
• C12P 17/12 - Nitrogen as only ring hetero atom containing a six-membered hetero ring
• A61K 9/00 - Medicinal preparations characterised by special physical form

Abstract

Disclosed are an apparatus for treating organic waste gas and a method for treating organic waste gas by using the apparatus. The apparatus comprises a pretreatment apparatus (1), a microwave reactor (5) and an absorption apparatus (6) that are sequentially connected by means of a gas delivery pipe and are used for deacidification, dealkalization and dust removal. An air pump (2), a volatile organic compound online detector (3) and a gas meter (4) are disposed on the gas delivery pipe between the pretreatment apparatus (1) and the microwave reactor (5). By using the apparatus and the method, high-concentration volatile organic waste gas can be treated, and low-concentration volatile organic gas can also be treated by means of the catalytic property of microwaves and the adsorption of a catalyst under the condition that the temperature of the organic gas is much lower than the catalytic combustion temperature.

IPC Classes  ?

• B01D 53/86 - Catalytic processes
• B01D 53/44 - Organic components

Abstract

A multi-function cooling and thermo-sensitive rack includes horizontal bars, a base, positioning holes, connectors, a lateral frame, connecting holes, a temperature-displaying prompter, and N temperature sensors. The lateral frame and the base are connected through the connectors. The lateral frame and the base have their surfaces facing each other symmetrically provided with plural connecting holes thereon. The horizontal bars have two ends thereof received in the corresponding symmetrical connecting holes. The positioning holes are distributed over the surface of the base. The N temperature sensors have output ends thereof for outputting sensing signals connected with input ends of the temperature-displaying prompter for inputting the N temperature-sensing signals. The present invention is applied to apparatuses used in microbiology experiment.

IPC Classes  ?

• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• B01L 9/06 - Test-tube standsTest-tube holders

Abstract

An assembled sterilization rack for sterile experiment relates to supporting devices used in experiment involving culture of microorganisms and/or cells. The rack includes a lateral frame, retaining wires, connectors, a base frame, heat resistant rods, connecting rings, a temperature-displaying control unit, and N temperature sensors. The lateral frame and the base frame are connected through the connectors. The lateral frame and the base frame have their surfaces facing each other provided with a plurality of retaining wires. The rods have two ends mounted on the symmetrically arranged retaining wires, respectively. The base frame has its upper surface provided with a plurality of connecting rings. The rods have the two ends received in the symmetrically arranged connecting rings, respectively. The temperature sensors are connected with the temperature-displaying control unit. In cell culture experiment, this invention can be applied to support elements used for vertical culture of cells in rectangular culture dishes.

IPC Classes  ?

• A61L 2/26 - Accessories
• B01L 9/00 - Supporting devicesHolding devices
• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
• B01L 9/06 - Test-tube standsTest-tube holders

Abstract

Disclosed is a method for synthesizing 3-ethoxy-4-ethoxycarbonyl phenylacetic acid. With m-hydroxyphenylacetic acid as a raw material, the 3-ethoxy-4-ethoxycarbonyl phenylacetic acid is separately synthesized in three ways. The involved reaction agents and reaction conditions are relatively mild, and the operation difficulty is lowered while the reaction risk is lowered. The present invention is applicable to the preparation of repaglinide intermediate-3-ethoxy-4-ethoxycarbonyl phenylacetic acid.

IPC Classes  ?

• C07C 67/313 - Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of doubly bound oxygen containing functional groups, e.g. carboxyl groups
• C07C 69/92 - Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with etherified hydroxyl groups

Abstract

Provided in the present invention is a sterilizable assembled bracket for aseptic technique experiments, comprising a side frame, stopper wires, a connecting member, a bottom frame, a heat-resistant bar, connecting rings, a temperature display and control unit and N temperature sensors, wherein the side frame and the bottom frame are connected by the connection member, a plurality of stopper wires are provided at the opposite surface of the side frame and the bottom frame, the two terminals of the heat-resistant bar are respectively symmetrically disposed on opposite stopper wires, a plurality of connection rings are provided on the upper surface of the bottom frame, the two teminals of the heat-resistant bar are respectively disposed symmetrically in opposite connection rings, and the N temperature sensors are in communication with the temperature display and control unit. The device is a support device for inoculation rings and spreaders in microorganism and cell culture experiments, and may also be used as a support device for vertical cell cultures in a square dish in cell culture experiments.

IPC Classes  ?

• C12M 1/00 - Apparatus for enzymology or microbiology
• B01L 9/00 - Supporting devicesHolding devices
• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus
• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters

Abstract

A microbial experiment cooling and temperature-sensing multipurpose rack comprising crossbars (1), a base (3), positioning holes (4), a connection element (5), an edge frame (6), and connection holes (7). The edge frame (6) is a U-shaped frame body and is identical in size with the base (3). The edge frame (6) and the base (3) are connected via the connection element (5). The multiple connection holes (7) are symmetrically provided on U-shaped arms of the edge frame (6). The crossbars (1) are horizontally fixed on the connection holes (7). The microbial experiment cooling and temperature-sensing multipurpose rack also comprises a temperature display prompter (8) and an N-number of temperature sensors (9). Alternatively, the crossbars (1) and/or the base (3) sense the temperature and change color.

IPC Classes  ?

• B01L 9/06 - Test-tube standsTest-tube holders
• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• C12M 3/00 - Tissue, human, animal or plant cell, or virus culture apparatus

Abstract

Disclosed in the present invention is a protein tyrosine phosphatase inhibitor. The preparation method therefor is: extracting the crude product from the Isaria fumosorosea Wize solid or liquid fermentation broth using ethyl acetate, ethanol, methanol, or a mixed solvent of chloroform and methanol; separating the obtained extract using column chromatography on silica gel; and obtaining the target product. The inhibitor can be used to prepare pharmaceutical compositions for treating and preventing diabetes, obesity and cancers.

IPC Classes  ?

• A61K 31/4418 - Non-condensed pyridinesHydrogenated derivatives thereof having a carbocyclic ring directly attached to the heterocyclic ring, e.g. cyproheptadine
• C07D 213/89 - Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
• A61P 3/04 - AnorexiantsAntiobesity agents
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
• A61P 35/00 - Antineoplastic agents