Abstract

The present invention pertains to a novel lappaconitine derivative, a method for producing same, and a pharmaceutical use thereof using osteogenesis-promoting activity. The lappaconitine derivative induces the differentiation of stem cells into osteoblasts, increases bone mineral density when administered to animal models of osteoporosis, and induces bone formation in animal models of bone fracture, and thus can be advantageously used for preventing, ameliorating, or treating bone-related diseases such as osteoporosis, as well as treating non-disease fractures caused by physical trauma.

IPC Classes  ?

• C07D 223/32 - Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
• A61K 9/20 - Pills, lozenges or tablets
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Abstract

The present invention relates to a novel lappaconitine derivative and a pharmaceutically acceptable salt thereof, a preparation method therefor, and a medical use thereof using osteogenesis-promoting activity. The lappaconitine derivative induces the differentiation of stem cells into preosteoblasts, and increases bone density when administered to an osteoporosis animal model, and induces osteogenesis, and thus can be effectively used for preventing, alleviating, or treating bone-related diseases such as osteoporosis.

IPC Classes  ?

• C07D 223/32 - Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• A61P 19/10 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Goods & Services

3-in-1 hair shampoos; make-up; cosmetic preparations for the hair and scalp; hair care preparations; cosmetic preparations for baths; beauty soap; shampoos; hand cleansers; whitening essences for skincare; cosmetic preparations for skin care; essential oils; tooth cleaning gels; toothpaste; foam cleansers for the skin; hair rinses; hair essences; toilet water; beauty masks; non-medicated hair treatment preparations for cosmetic purposes; cosmetics. nutraceuticals based on eggs; protein dietary supplements; hair growth stimulants; vitamins and mineral dietary supplements; pharmaceutical preparations for skin care; nutraceuticals for use as a dietary supplement; dietary supplements consisting of amino acids, minerals, and micronutrients; acne treatment preparations; medicated scalp treatment cream; medicated hair care preparations; medicated shampoos; medicated dietary supplements; medicated hair growth preparations; medicated toothpaste; medicated skin care preparations; pharmaceutical compounds; medicinal creams; pharmaceutical preparations; nutraceuticals for treatment and medical purposes; mixed vitamin preparations.

Goods & Services

3-in-1 hair shampoos; make-up; cosmetic preparations for the hair and scalp; hair care preparations; cosmetic preparations for baths; beauty soap; shampoos; hand cleansers; skin whitening preparations, namely, skin essences; cosmetic preparations for skin care; essential oils; tooth cleaning gels; toothpaste; skin cleansers in the nature of foam cleansers for the skin; hair rinses; hair essences in the nature of hair care creams; toilet water; beauty masks; non-medicated hair treatment preparations for cosmetic purposes; cosmetics Nutraceuticals for use as a dietary supplement in the nature of nutraceuticals based mainly on eggs; protein dietary supplements; hair growth stimulants; vitamins and mineral dietary supplements; pharmaceutical preparations for skin care; nutraceuticals for use as a dietary supplement; dietary supplements consisting of amino acids, minerals, and micronutrients; acne treatment preparations; medicated scalp treatment cream; medicated hair care preparations; medicated shampoos; medicated dietary supplements for foodstuff for humans; medicated hair growth preparations; medicated toothpaste; medicated skin care preparations; biometallic compounds being a component in pharmaceutical preparations for bone fractures; medicinal creams for skin care; nutraceuticals for treatment and medical purposes, namely, for the treatment of constipation and osteoporosis; mixed vitamin preparations

Abstract

The present invention relates to a novel use of a Sanguisorba officinalis Linne extract in inhibiting the 3CL protease and RdRp activity of SARS-CoV-2 virus, and a composition of the present invention comprising the Sanguisorba officinalis Linne extract as an active ingredient has the effect of preventing or treating infection with SARS-CoV-2 virus or variants thereof by inhibiting the 3CL protease and RdRp activity.

IPC Classes  ?

• A61K 36/739 - Sanguisorba (burnet)
• A61P 31/14 - Antivirals for RNA viruses

Abstract

The present invention relates to a novel oxidized lappaconitine derivative and a pharmaceutically acceptable salt thereof, a preparation method therefor, and a medical use thereof using osteogenesis-promoting activity. The lappaconitine derivative induces the differentiation of stem cells into preosteoblasts, and increases bone density when administered to an osteoporosis animal model, and induces osteogenesis, and thus can effectively used for preventing, alleviating, or treating bone-related diseases such as osteoporosis.

IPC Classes  ?

• C07D 223/32 - Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• A61P 19/00 - Drugs for skeletal disorders
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Abstract

The present invention pertains to a novel lappaconitine derivative, a method for producing same, and a pharmaceutical use thereof using osteogenesis-promoting activity. The lappaconitine derivative induces the differentiation of stem cells into osteoblasts, increases bone density when administered to animal models of osteoporosis, and induces bone formation in animal models of bone fracture, and thus can be advantageously used for preventing, ameliorating, or treating bone-related diseases such as osteoporosis, as well as for treating non-disease fractures caused by physical trauma.

IPC Classes  ?

• C07D 223/32 - Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
• A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
• A61P 19/00 - Drugs for skeletal disorders
• A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives

Goods & Services

Solid-type makeup soap being beauty soap; cosmetic preparations for skin care; shampoo; non-medicated scalp protection and treatment cream; make-up; hair essence being hair styling preparations; cosmetic preparations for bath and shower; non-medicated skin care lotion; essential oils; tooth whitening and cleansing gel; toothpaste; face and body care cosmetics; skin cleansing foam being foam cleansers for personal use; perfume; hair conditioner; non-medicated skin toner; cosmetic mask; flower essences for cosmetic purposes

Goods & Services

Solid-type makeup soap being beauty soap; cosmetic preparations for skin care; shampoo; non-medicated scalp protection and treatment cream; make-up; hair essence being hair styling preparations; cosmetic preparations for bath and shower; non-medicated skin care lotion; essential oils; tooth whitening and cleansing gel; toothpaste; face and body care cosmetics; skin cleansing foam being foam cleansers for personal use; perfume; hair conditioner; non-medicated skin toner; cosmetic mask; flower essences for cosmetic purposes