A method and a system for preparing a biomaterial from at least two components, said method comprising the steps of:
providing at least two biomaterial components in a mixing compartment (3) of the preparation system (1; 1′);
measuring at least one feature in the preparation system with at least one sensor (7), said at least one feature comprising at least temperature and/or humidity;
mixing said at least two biomaterial components by a mixing device (5) of the preparation system (1; 1′) to which mixing device (5) said mixing compartment (3) can be or is connected;
controlling said mixing by a control unit (9) of the preparation system (1; 1′), said control unit (9) being in communication contact with said mixing device (5) and with said at least one sensor (7), wherein said mixing is controlled such that at least one mixing parameter of said mixing is dependent on a value of said at least one measured feature.
The devices, systems, and methods herein described provide uniform biomaterial delivery to produce robust adhesion between an implant (e.g., an implantable screw) and a bone tissue. Furthermore, the devices, systems, and methods of the disclosure overcome challenges associated with the repair of weak or deficient bone and augmentation using injected biomaterials.
The present invention relates to a powder composition that may be used as an adhesive when mixed with water. The composition is based on a calcium phosphate, a phosphorylated amino acid and an acidic compound.
The present invention relates to a soft tissue adhesive comprising an aqueous composition comprising α-TCP and a phosphorylated amino acid. The composition has improved mechanical strength and is casily applied to the tissue.
The present invention relates the use of bone graft particles for the preparation of a porous bone graft material comprising an acid containing self-setting adhesive composition. Said bone graft particles have a porous core with an outer surface which is at least partially covered by an outer layer. The core comprises a core material selected from the group consisting of an alloplast, a bone xenograft, and a bone allograft, or a mixture thereof. The outer layer of said particles comprises a carbonate salt.
A61L 27/46 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
The present invention relates to a two-component composition comprising a first component A comprising water or an aqueous solution and a second component B comprising a self-setting adhesive powder comprising at least a multivalent metal salt and phosphoserine, and at least one hydrogen carbonate, characterized in that the hydrogen carbonate is present in a concentration between 1 and 8 % by weight of component B.
A61L 24/00 - Surgical adhesives or cementsAdhesives for colostomy devices
A61L 27/44 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
A61L 27/46 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
A61K 6/30 - Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives
A61K 6/60 - Preparations for dentistry comprising organic or organo-metallic additives
The present invention relates to a two-component composition comprising a first component A comprising water or an aqueous solution, and a second component B comprising a self-setting adhesive powder comprising at least a multivalent metal salt and phosphoserine, and at least one monocarbonate selected from the group consisting of sodium carbonate, ammonium carbonate and potassium carbonate, characterized in that the monocarbonate is present in a concentration between 4 and 12% by weight of component B.
A61L 24/00 - Surgical adhesives or cementsAdhesives for colostomy devices
A61L 27/44 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
A61L 27/46 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
A preparation system (1a-1h) for preparing a biomaterial from at least two components, said preparation system comprising a flexible mixing pouch (3a-3f) and a preparation housing (21a-21h) inside which said mixing pouch (3a-3f) is provided when the biomaterial is to be prepared. The preparation housing (21a-21h) comprises a housing outlet (23), at least one mixing pouch contacting device (25a-25h) configured for affecting said mixing pouch (3a-3f) by compressing the mixing pouch from an outside of the mixing pouch and at least one actuator (27; 27a, 27b) connected to the at least one mixing pouch contacting device (25a- 25h) and by which a position of said at least one mixing pouch contacting device (25a-25h) can be controlled such that both mixing of the components inside said mixing pouch (3a-3f) and delivery of the mixed components out from the mixing pouch via the pouch outlet (11) and the housing outlet (23) can be performed.
B01F 31/55 - Mixers with shaking, oscillating, or vibrating mechanisms the materials to be mixed being contained in a flexible bag submitted to periodical deformation
A method and a system for preparing a biomaterial from at least two components, said method comprising the steps of: providing at least two biomaterial components in a mixing compartment (3) of the preparation system (1; 1'); measuring at least one feature in the preparation system with at least one sensor (7), said at least one feature comprising at least temperature and/or humidity; mixing said at least two biomaterial components by a mixing device (5) of the preparation system (1; 1') to which mixing device (5) said mixing compartment (3) can be or is connected; controlling said mixing by a control unit (9) of the preparation system (1; 1'), said control unit (9) being in communication contact with said mixing device (5) and with said at least one sensor (7), wherein said mixing is controlled such that at least one mixing parameter of said mixing is dependent on a value of said at least one measured feature.
B01F 35/221 - Control or regulation of operational parameters, e.g. level of material in the mixer, temperature or pressure
B01F 35/222 - Control or regulation of the operation of the driving system, e.g. torque, speed or power of motorsControl or regulation of the position of mixing devices or elements
10.
DEVICES, SYSTEMS, AND METHODS FOR BONE REPAIR OR IMPLANT FIXATION
The devices, systems, and methods herein described provide uniform biomaterial delivery to produce robust adhesion between an implant (e.g., an implantable screw) and a bone tissue. Furthermore, the devices, systems, and methods of the disclosure overcome challenges associated with the repair of weak or deficient bone and augmentation using injected biomaterials.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical preparations and veterinary preparations for use in wound healing and osteoporosis; Bone morphogenetic protein material for use in body implantable medical devices to induce bone formation and growth into such devices; biomimetic adhesive for bone repair and bone adhesive preparation Medical devices and apparatus for medical and veterinary use in skeletal repair and wound healing; medical devices for enhancing fixation in bone Custom manufacturing of medical devices for others; custom manufacturing of medical devices incorporating Bone morphogenetic protein material for use in body implantable medical devices to induce bone formation and growth into such devices Product development for the medical devices industry; Consultancy in the field of medical devices development; Scientific and technological services, namely, scientific research, analysis, testing of medical devices in the field of medical and veterinary applications; Development of medical devices prototypes
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
40 - Treatment of materials; recycling, air and water treatment,
42 - Scientific, technological and industrial services, research and design
Goods & Services
Pharmaceutical preparations and veterinary preparations for professional use; Bone morphogenetic protein material for use in body implantable medical devices to induce bone formation and growth into such devices; biomimetic adhesive for bone repair and bone adhesive preparation. Medical devices and apparatus for medical and veterinary use; medical devices for enhancing fixation in bone. Custom manufacturing of medical devices for others; manufacturing of medical devices incorporating Bone morphogenetic protein material for use in body implantable medical devices to induce bone formation and growth into such devices. Product development for the medical devices industry; Consultancy in the field of medical devices development; Scientific and technological services relating to medical devices; Development of medical devices prototypes.
13.
COMPOSITION OF ALPHA-TCP, SILICATE AND PHOSPHORYLATED AMINO ACID
The present invention relates to an aqueous composition comprising an aqueous solution, α-TCP, a silicate compound and a phosphorylated amino acid. The composition has improved mechanical strength and is easily applied and may be used as a tissue adhesive, implant or a filler.
The present invention relates to a soft tissue adhesive comprising an aqueous composition comprising α-TCP and a phosphorylated amino acid. The composition has improved mechanical strength and is easily applied to the tissue.
