Abstract

A system for high gain stimulated Raman spectroscopy comprises a first continuous wave laser having an output beam at a tunable optical frequency modulated at a first RF frequency, a second continuous wave laser having a second output beam at an optical frequency modulated at a second RF frequency, wherein the modulation frequencies are selected such that their beat notes represent a Raman resonance frequency, a dual-beam rasterizing probe including first and second photosensors and a rasterizer configured to scan the first and second laser output beams onto a sample, exposing the sample to a reduced average power of laser radiation stimulating the sample to emit Raman radiation signals. The Raman signals are directed to the photosensors and the outputs of the photosensors are supplied to a differential amplifier configured to provide sensitivity and gain to signals at the beat note resonant frequency and to filter signals at other frequencies.

IPC Classes  ?

• G01J 3/02 - SpectrometrySpectrophotometryMonochromatorsMeasuring colours Details
• G01J 3/10 - Arrangements of light sources specially adapted for spectrometry or colorimetry
• G01J 3/06 - Scanning arrangements
• G01N 21/65 - Raman scattering
• G01J 3/44 - Raman spectrometryScattering spectrometry

Abstract

A system for high gain stimulated Raman spectroscopy comprises a first continuous wave laser having an output beam at a tunable optical frequency modulated at a first RF frequency, a second continuous wave laser having a second output beam at an optical frequency modulated at a second RF frequency, wherein the modulation frequencies are selected such that their beat notes represent a Raman resonance frequency, a dual-beam rasterizing probe including first and second photosensors and a rasterizer configured to scan the first and second laser output beams onto a sample, exposing the sample to a reduced average power of laser radiation stimulating the sample to emit Raman radiation signals. The Raman signals are directed to the photosensors and the outputs of the photosensors are supplied to a differential amplifier configured to provide sensitivity and gain to signals at the beat note resonant frequency and to filter signals at other frequencies.

IPC Classes  ?

• G01J 3/44 - Raman spectrometryScattering spectrometry
• G01N 21/65 - Raman scattering
• G01J 3/10 - Arrangements of light sources specially adapted for spectrometry or colorimetry
• G01J 3/06 - Scanning arrangements

Abstract

A system for non-invasively interrogating an in vivo sample for measurement of analytes comprises a pulse sensor coupled to the in vivo sample for detect a blood pulse of the sample and for generating a corresponding pulse signal, a laser generator for generating a laser radiation having a wavelength, power and diameter, the laser radiation being directed toward the sample to elicit Raman signals, a laser controller adapted to activate the laser generator, a spectrometer situated to receive the Raman signals and to generate analyte spectral data; and a computing device coupled to the pulse sensor, laser controller and spectrometer which is adapted to correlate the spectral data with the pulse signal based on timing data received from the laser controller in order to isolate spectral components from analytes within the blood of the sample from spectral components from analytes arising from non-blood components of the sample.

IPC Classes  ?

• G01J 3/44 - Raman spectrometryScattering spectrometry
• G01J 3/02 - SpectrometrySpectrophotometryMonochromatorsMeasuring colours Details
• G01J 3/06 - Scanning arrangements
• G01N 21/65 - Raman scattering
• G01N 33/49 - Physical analysis of biological material of liquid biological material blood

Abstract

A system for non-invasively interrogating an in vivo sample for measurement of analytes comprises a pulse sensor coupled to the in vivo sample for detect a blood pulse of the sample and for generating a corresponding pulse signal, a laser generator for generating a laser radiation having a wavelength, power and diameter, the laser radiation being directed toward the sample to elicit Raman signals, a laser controller adapted to activate the laser generator, a spectrometer situated to receive the Raman signals and to generate analyte spectral data; and a computing device coupled to the pulse sensor, laser controller and spectrometer which is adapted to correlate the spectral data with the pulse signal based on timing data received from the laser controller in order to isolate spectral components from analytes within the blood of the sample from spectral components from analytes arising from non-blood components of the sample.

IPC Classes  ?

• G01J 3/02 - SpectrometrySpectrophotometryMonochromatorsMeasuring colours Details
• G01J 3/44 - Raman spectrometryScattering spectrometry
• G01N 21/65 - Raman scattering
• G01J 3/06 - Scanning arrangements
• G01N 33/49 - Physical analysis of biological material of liquid biological material blood

Abstract

A system for non-invasively interrogating an in vivo sample for measurement of analytes comprises a pulse sensor coupled to the in vivo sample for detect a blood pulse of the sample and for generating a corresponding pulse signal, a laser generator for generating a laser radiation having a wavelength, power and diameter, the laser radiation being directed toward the sample to elicit Raman signals, a laser controller adapted to activate the laser generator, a spectrometer situated to receive the Raman signals and to generate analyte spectral data; and a computing device coupled to the pulse sensor, laser controller and spectrometer which is adapted to correlate the spectral data with the pulse signal based on timing data received from the laser controller in order to isolate spectral components from analytes within the blood of the sample from spectral components from analytes arising from non-blood components of the sample.

IPC Classes  ?

• G01N 21/00 - Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
• A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
• G01N 21/65 - Raman scattering
• G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers

Abstract

A system for non-invasively interrogating an in vivo sample for measurement of analytes comprises a pulse sensor coupled to the in vivo sample for detect a blood pulse of the sample and for generating a corresponding pulse signal, a laser generator for generating a laser radiation having a wavelength, power and diameter, the laser radiation being directed toward the sample to elicit Raman signals, a laser controller adapted to activate the laser generator, a spectrometer situated to receive the Raman signals and to generate analyte spectral data; and a computing device coupled to the pulse sensor, laser controller and spectrometer which is adapted to correlate the spectral data with the pulse signal based on timing data received from the laser controller in order to isolate spectral components from analytes within the blood of the sample from spectral components from analytes arising from non-blood components of the sample.

IPC Classes  ?

• G01N 21/00 - Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
• G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers
• G01N 21/65 - Raman scattering
• A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters