Goods & Services

Veterinary apparatus and instruments.

Abstract

The invention relates to a device (1) for holding a microfluidic cartridge (3), the device comprising: - a base (19) arranged to support a microfluidic cartridge (3); and - a cover (21) having an opening (29) and connected to the base (19) by a pivot connection (31), which pivot connection (31) allows the cover (21) to pivot so as to reach a closed position in which, when a microfluidic cartridge (3) is supported by the base (19), the opening (29) is opposite a fluidic inlet (13) of the microfluidic cartridge (3). The device (1) further comprises a flushing system (23) arranged to selectively connect the opening (29) to a reservoir in order to flush a microfluidic cartridge (3) supported by the base (19).

IPC Classes  ?

• B01L 9/00 - Supporting devices; Holding devices

Abstract

The present invention concerns a method for the molecular detection of an infectious agent based on isothermal amplification by recombinase polymerase amplification (RPA) combined with a Magnetic Field-Enhanced Agglutination (MFEA) readout.

IPC Classes  ?

• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
• C12Q 1/6804 - Nucleic acid analysis using immunogens
• C12Q 1/6844 - Nucleic acid amplification reactions
• C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

Abstract

A measurement method for determining the concentration of reticulocytes or nucleated red blood cells contained in a blood specimen, the measurement method including a staining step, a removal step and a measurement step. In the staining step, reticulocytes or nucleated red blood cells, among red blood cells contained in the blood specimen, are stained. In the removal step, a surfactant is added to the blood specimen to take out hemoglobin from the red blood cells. In the measurement step, the concentration of the reticulocytes or nucleated red blood cells contained in the blood specimen is determined using the blood specimen after the staining and removal steps.

IPC Classes  ?

• G01N 33/49 - Physical analysis of biological material of liquid biological material blood

Abstract

The invention relates to a device (1) for counting and differentiating particles comprising: - a heating base (3) inside which a channel (9) for injecting a sample flow and a channel (11) for injecting a tubing flow are provided, and - a measuring cell (5) comprising an optical cell (17) arranged to be passed through by a tubed sample flow, a light source (33) arranged to illuminate the tubed sample flow, a detector (41) arranged to receive a fluorescence signal emitted by a light-absorbed particle and a channel (23) for discharging the tubed sample flow. The detector (41) is arranged to measure fluorescence in order to differentiate the particles. The heating base (3) and the discharge channel (23) form measuring electrodes arranged to measure resistivity in order to count the particles.

IPC Classes  ?

• G01N 15/12 - Coulter-counters
• G01N 1/30 - Staining; Impregnating
• G01N 15/14 - Electro-optical investigation

Abstract

The invention relates to a device for detecting particles by means of lensless imaging, the device comprising a memory (4) arranged to receive a plurality of z-stack images obtained from a lensless image of a biological sample, a picker (6) arranged to determine, on the basis of the z-stack images, a focus image in which each pixel is associated on the one hand with a z-stack image and on the other hand with the intensity of this pixel in this z-stack image, the picker (6) being arranged to determine the z-stack image for a given pixel by calculating, for each of the z-stack images and for the given pixel, the parsimony score on the basis of the intensity of the given pixel and on the intensities of neighbouring pixels, and by selecting the z-stack image for which the parsimony score is highest, a selector (10) arranged to determine, for each pixel of the focus image, whether this pixel is a maximum in a local neighbourhood centred on this pixel in the focus image or in the z-stack image associated with this pixel in the focus image, and, if if it is, to store this pixel in a list of selected sites, and a computer (12) arranged to calculate a metric value for each pixel in the list of selected sites on the basis of the intensity of these pixels to produce an image of the metric values for distinguishing the particles associated with each pixel in the list of selected sites from one another.

IPC Classes  ?

• G06T 5/50 - Image enhancement or restoration by the use of more than one image, e.g. averaging, subtraction
• G06T 5/00 - Image enhancement or restoration
• G03H 1/00 - HOLOGRAPHIC PROCESSES OR APPARATUS - Details peculiar thereto
• G03H 1/04 - Processes or apparatus for producing holograms
• G03H 1/08 - Synthesising holograms

Abstract

The invention relates to a device for determining sedimentation rate comprising at least one member (8) for sampling a blood sample, and a sensor (20) comprising an infrared light source (12) and an optical sensor (14) that are placed substantially opposite each other about a substantially transparent segment (16) of the sampling member (8) such that the light emitted by the infrared light source (12) reaches the optical sensor (14) after having passed through said substantially transparent segment (16). The optical sensor (14) is arranged to take a blank measurement, the device further comprising a converter (10) that is arranged to receive one or more measurements of light transmittance from the optical sensor (14), with a view to computing the ratio between the blank measurement and the one or more measurements of light transmittance and to returning a sedimentation rate.

IPC Classes  ?

• G01N 15/05 - Investigating sedimentation of particle suspensions in blood
• G01N 21/27 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection

Abstract

A device for spreading or staining and for determining a sedimentation rate comprises a first group (4) arranged to collect a blood sample from a tube and to produce a smear of this sample, and a second group (6) arranged to collect a blood sample from a tube and to carry out a sedimentation rate determination. The device comprises at least one sampling member (8) controllable for an operation by the first group (4) and an operation by the second group (6) for taking a blood sample so that a sample taken for the first group (4) is not used by the second group (6), and that a sample taken for the second group (6) is not used by the first group (4), the second group (6) being provided with a sensor (20) comprising an infrared light source (12) and an optical sensor (14) which are arranged substantially opposite each other around a tube (16) connected to an outlet end of the at least one sampling member (8) so that the light emitted by the infrared light source (12) reaches the optical sensor (14) after passing through said tube (16). The device further comprises a converter (10) arranged to receive one or more light-transmission measurements from the optical sensor (14) and to determine a sedimentation rate.

IPC Classes  ?

• G01N 1/28 - Preparing specimens for investigation
• G01N 1/30 - Staining; Impregnating
• G01N 15/05 - Investigating sedimentation of particle suspensions in blood
• G01N 21/27 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection

Abstract

A device for performing a full blood count and for determining a sedimentation rate comprises a first group (4) arranged to collect a blood sample from a tube and to carry out a full blood count on this sample, characterized in that it comprises a second group (6) arranged to take a blood sample from a tube and to carry out a sedimentation rate determination. This device comprises at least one sampling member (8) controllable for a measurement by the first group (4) and a measurement by the second group (6) for taking a blood sample so that a sample taken for the first group (4) is not used by the second group (6), and that a sample taken for the second group (6) is not used by the first group (4), the second group (6) being provided with a sensor (20) comprising an infrared light source (12) and an optical sensor (14) which are arranged substantially opposite each other around a tube (16) connected to an outlet end of the at least one sampling member (8) so that the light emitted by the infrared light source (12) reaches the optical sensor (14) after passing through said tube (16). The device further comprises a converter (10) arranged to receive one or more light-transmission measurements from the optical sensor (14) and to determine a sedimentation rate.

IPC Classes  ?

• G01N 15/05 - Investigating sedimentation of particle suspensions in blood
• G01N 21/27 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection

Abstract

The invention is directed to a method for assaying a target analyte in a biological sample in liquid medium, comprising the following steps: (a.) contacting the biological sample with first magnetic particles (10) bearing a first receptor (101) specific to a first site of attachment of the target analyte (20) so as to form first complexes by the bonding of first magnetic particles (10) with the target analyte (20), this contacting being accompanied, when an interfering analyte (30) is present in the sample, by the formation of interfering complexes by the non-specific bonding of said interfering analyte (30) to the first magnetic particles (10); (b.) applying a first magnetic field, and maintaining it, so as to locally combine all of the complexes formed in step a., and where appropriate to agglomerate interfering complexes with one another to form interfering aggregates; (c.) negating the magnetic field applied in step b. and adding second magnetic particles (11) to the liquid medium that bear a second receptor (111) specific to a second site of attachment of the target analyte (20); (d.) measuring a first quantity representative of the amount of interfering aggregates in the liquid medium, for identifying the presence or absence of said interfering aggregates; (e.) applying a second magnetic field so as to form second complexes (61) by the bonding of the first complexes with second magnetic particles (11); and (f.) measuring a second quantity representative of the collective amount of interfering aggregates and of second complexes (61) in the liquid medium so as to determine the amount of second complexes (61) formed in step e. as a function of the first quantity, for deducing therefrom the amount of target analyte (20) present in the biological sample and, where appropriate, the amount of interfering analyte.

IPC Classes  ?

• G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 27/74 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating magnetic variables of fluids

Abstract

A medical analysis device with cellular impedance signal processing comprises a memory (4) arranged to receive pulse data sets, each pulse data set comprising impedance value data that are associated each time with a time marker, these data together representing a curve of cellular impedance values that are measured as a cell passes through a polarised opening. This device further comprises a classifier (6) comprising a convolutional neural network receiving the pulse data sets as input and is provided with at least one convolutional layer, which convolutional layer has a depth greater than or equal to 3, and at least two fully connected layers, in addition to an output layer rendering a cell classification from which a pulse data set is derived.

IPC Classes  ?

• G01N 15/12 - Coulter-counters
• G01N 33/487 - Physical analysis of biological material of liquid biological material

Abstract

An electro-optical device for taking flow measurements includes a measurement tank through which a flow of fluid to be characterized flows, at least first and second guns for emitting light having separate spectra, a triggering gun allowing diffraction to be measured at small angles and a receiving gun allowing a measurement of attenuation and at least one fluorescence to be taken. The first emitting gun includes a light source defining a main optical axis perpendicular to the fluid flow, and the second emitting gun includes a second light source defining a secondary optical axis substantially orthogonal to the main optical axis and fluid flow. The first and second emitting guns are placed on one side of the measurement tank, the receiving gun is placed on the other side of the measurement tank along the main optical axis and the triggering gun is placed on the other side of the tank.

IPC Classes  ?

• G01N 15/14 - Electro-optical investigation
• G01N 15/02 - Investigating particle size or size distribution

Abstract

The present invention concerns a method for the molecular detection of an infectious agent based on isothermal amplification by recombinase polymerase amplification (RPA) combined with a Magnetic Field-Enhanced Agglutination (MFEA) readout.

IPC Classes  ?

• C12Q 1/686 - Polymerase chain reaction [PCR]
• C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage

Abstract

The present invention concerns a method for the molecular detection of an infectious agent based on isothermal amplification by recombinase polymerase amplification (RPA) combined with a Magnetic Field-Enhanced Agglutination (MFEA) readout.

IPC Classes  ?

• C12Q 1/686 - Polymerase chain reaction [PCR]
• C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria

Abstract

A device for medical analyses with cellular impedance signal processing comprises a memory (4) arranged to receive pulse data sets, each pulse data set comprising impedance value data that are associated each time with a time marker, these data together representing a curve of cellular impedance values that are measured as a cell passes through a polarized opening, a computer (6) arranged to process a pulse data set by determining a rotation value indicating whether the cell from which this pulse data set has been taken has undergone a rotation during its passage through the polarized opening, and a classifier (8) arranged to retrieve from the computer (6) a given pulse data set, and to use the resulting rotation value to classify the given pulse data set in a rotation pulse data set group (10) or a rotationless pulse data set group (12).

IPC Classes  ?

• G01N 15/10 - Investigating individual particles
• G01N 15/12 - Coulter-counters
• G01N 15/02 - Investigating particle size or size distribution

Abstract

A method for characterizing a particle present in a sample, the sample lying between an image sensor and a light source and the sensor lying in a detection plane, includes illuminating the sample with the light source which emits an incident light wave propagating along a propagation axis, and acquiring an image of the sample with the sensor. The sensor is exposed to an exposure light wave. The image includes a plurality of elementary diffraction patterns each corresponding to one particle. The method also includes reconstructing a complex image representative of a complex amplitude of the light wave on a reconstruction surface passing through the sample, based on the acquired image; selecting a region of interest of the complex image corresponding to a particle of interest; forming an extracted image based on the region of interest; and characterizing the particle of interest depending on the extracted region of interest.

IPC Classes  ?

• G01N 15/1434 - Optical arrangements
• G03H 1/08 - Synthesising holograms

Abstract

A device for preparing a solution from a sample and a reagent, the device includes a microfluidic array having a sample supply inlet, a reagent supply inlet, a discharge outlet, a solution collection outlet, a sampling zone to which the inlets are connected, first and second preparation chambers connected to the sampling zone, arranged to either side of the sampling zone such that the liquid flowing from one preparation chamber to the other flows through the first sampling zone, the first preparation chamber having a volume that is variable between a minimum volume and a calibrated volume. The device includes valves interrupting the flow of the fluid at least at the two inlets and the collection and discharge outlets.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
• G01N 1/38 - Diluting, dispersing or mixing samples
• G01F 11/28 - Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with stationary measuring chambers having constant volume during measurement
• B01F 15/04 - Forming a predetermined ratio of the substances to be mixed

Abstract

An electro-optical device for taking measurements of flow comprises a measurement tank (8) through which a flow of fluid to be characterised flows, at least two guns (4, 6) for emitting light having separate spectra, a triggering gun (9) allowing diffraction to be measured at small angles and a receiving gun (10) allowing a measurement of attenuation and at least one fluorescence to be taken. The first emitting gun (4) comprises a light source (40) defining a main optical axis perpendicular to the fluid flow, and the second emitting gun (6) comprises a second light source (60) defining a secondary optical axis substantially orthogonal to the main optical axis and to the fluid flow. The first emitting gun (4) and the second emitting gun (6) are placed on one side of the measurement tank (8), the receiving gun (10) is placed on the other side of the measurement tank (8) along the main optical axis, and the triggering gun (9) is placed on the other side of the measurement tank (8) along the secondary optical axis. The receiving gun (10) comprises a detection channel (12) for measuring attenuation and at least one detection channel (14) for measuring at least one fluorescence signal, and a single objective (11) for collecting the beam originating from the interaction of the light beam between the first emitting gun (4) and the second emitting gun (6) and the particles in the fluid flow, said objective being arranged so that the light beam is substantially collimated along the main optical axis toward the detection channel (12) for measuring attenuation, the receiving gun (10) forming a single mechanical unit at least one portion of which is movable with respect to the measurement tank (8). The receiving gun (10) furthermore comprises a first dichroic mirror (18) located downstream of the collecting objective (11) where the light beam is substantially collimated, said mirror being arranged to partially transmits the light beam generated by the interaction between the first emitting gun (4) and the particles in the fluid flow to the detection channel (12) for measuring attenuation, and to partially reflect the light beam generated by the interaction between the second emitting gun (6) and the particles in the fluid flow to at least one detection channel (14) for measuring at least one fluorescence signal.

IPC Classes  ?

• G01N 15/14 - Electro-optical investigation
• G01N 21/64 - Fluorescence; Phosphorescence
• G01N 15/10 - Investigating individual particles

Abstract

A medical analysis device with cellular impedance signal processing comprises a memory (4) arranged to receive pulse data sets, each pulse data set comprising impedance value data that are associated each time with a time marker, these data together representing a curve of cellular impedance values that are measured as a cell passes through a polarised opening. This device further comprises a classifier (6) comprising a convolutional neural network receiving the pulse data sets as input and is provided with at least one convolutional layer, which convolutional layer has a depth greater than or equal to 3, and at least two fully connected layers, in addition to an output layer rendering a cell classification from which a pulse data set is derived.

IPC Classes  ?

• G01N 15/12 - Coulter-counters

Abstract

The invention relates to a method for counting particles, particularly blood cells, in a sample, using a lensless optical imaging device. The sample is arranged between a light source and an image sensor. The sample is illuminated by a light source and an image is acquired by the image sensor, said image sensor being exposed to a light wave called an exposition wave. A digital propagation operator is applied to the acquired image so as to obtain a complex amplitude of the exposition wave according to a surface facing the image sensor. An image, called a reconstructed image, is formed from the modulus and/or the phase of said complex amplitude, on which image the particles to be counted appear in the form of regions of interest. The method then comprises a step of selecting the regions of interest corresponding to the particles to be counted.

IPC Classes  ?

• G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
• G01N 15/14 - Electro-optical investigation
• G01N 15/00 - Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials

Abstract

A device for medical analyses with cellular impedance signal processing comprises a memory (4) arranged to receive pulse data sets, each pulse data set comprising impedance value data that are associated each time with a time marker, these data together representing a curve of cellular impedance values that are measured as a cell passes through a polarized opening, a computer (6) arranged to process a pulse data set by determining a rotation value indicating whether the cell from which this pulse data set has been taken has undergone a rotation during its passage through the polarized opening, and a classifier (8) arranged to retrieve from the computer (6) a given pulse data set, and to use the resulting rotation value to classify the given pulse data set in a rotation pulse data set group (10) or a rotationless pulse data set group (12).

IPC Classes  ?

• G01N 15/12 - Coulter-counters

Abstract

i) depending on the complex expressions calculated during step c).

IPC Classes  ?

• G01N 15/02 - Investigating particle size or size distribution
• G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
• G06T 7/11 - Region-based segmentation
• G01N 15/14 - Electro-optical investigation
• G03H 1/00 - HOLOGRAPHIC PROCESSES OR APPARATUS - Details peculiar thereto
• G03H 1/08 - Synthesising holograms
• G01N 15/00 - Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials

Abstract

Method for characterising a sample (10), lying in a sample plane, the method comprising the following steps: a) illuminating the sample using a light source (11, 11'), such that, under the effect of the illumination, an image sensor (20) is exposed to an exposing light wave (14) that is transmitted or reflected by the sample; b) obtaining a plurality of defocused images (Iz) of the sample; c) from the images obtained in step b), computing, at various radial coordinates (r), in the detection plane (P), an axial variation; d) from the axial variation computed in step c), obtaining a phase image (Iφ); e) characterising the sample using the obtained phase image (Iφ).

IPC Classes  ?

• G01N 21/956 - Inspecting patterns on the surface of objects
• G01J 9/00 - Measuring optical phase difference; Determining degree of coherence; Measuring optical wavelength
• G01N 21/41 - Refractivity; Phase-affecting properties, e.g. optical path length
• G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes
• G02B 21/08 - Condensers

Abstract

Method for characterising a particle present (10p) in a sample (10), the sample extending between an image sensor (16) and a light source (11), the image sensor extending along a plane of detection (Po), the method comprising: - illumination of the sample by the light source, the light source emitting an incident light wave (12) propagating along an axis of propagation (Z); - acquisition of an image of the sample by the image sensor (20), the image sensor being exposed to an exposure light wave (14), the image comprising a plurality of basic diffraction patterns, each basic diffraction pattern corresponding to a particle; - reconstruction, from the image acquired, of a complex image that is representative of a complex amplitude of the exposure light wave on a reconstruction surface passing through the sample; - selection of a region of interest in the complex image, the region of interest selected corresponding to a particle of interest; - formation of an image extracted from the region of interest selected in step d); characterisation of the particle of interest on the basis of the region of interest extracted in this manner.

IPC Classes  ?

• G03H 1/00 - HOLOGRAPHIC PROCESSES OR APPARATUS - Details peculiar thereto
• G03H 1/08 - Synthesising holograms
• G01N 21/27 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
• G01N 21/82 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a precipitate or turbidity

Abstract

Disclosed is a device for preparing a solution from a sample and a reagent, comprising a microfluidic array comprising a sample supply inlet (E1), a reagent supply inlet (E2), a discharge outlet (S1), a solution collection outlet (S2), a sampling zone (ZE) to which the inlets (E1, E2) are connected, first (4) and second (6) preparation chambers connected to the sampling zone (ZE), arranged to either side of the sampling zone (ZE) such that the liquid flowing from one preparation chamber to the other flows through the first sampling zone (ZE), the first preparation chamber (4) having a volume that is variable between a minimum volume and a calibrated volume. The device comprises valves interrupting the flow of the fluid at least at the two inlets (E1, E2) and the collection (S2) and discharge (S1) outlets.

IPC Classes  ?

• G01N 1/38 - Diluting, dispersing or mixing samples
• B01F 13/00 - Other mixers; Mixing plant, including combinations of dissimilar mixers
• B01J 19/00 - Chemical, physical or physico-chemical processes in general; Their relevant apparatus
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
• B01F 11/00 - Mixers with shaking, oscillating, or vibrating mechanisms
• B01F 15/04 - Forming a predetermined ratio of the substances to be mixed
• G05D 11/00 - Control of flow ratio
• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

Abstract

A biological analysis system comprising at least one inlet and one outlet, at least two biological analysis devices connected to one another by a conveyor defining a closed circuit, each biological analysis device comprising a region for the exchange of tube holding racks with the conveyor. The conveyor and the at least one inlet of the biological analysis system comprise a reader of an identifier of a tube holding rack which reader is designed to communicate an identifier it has read to a controller of the biological analysis system, which controller is designed to apply a specific treatment to a tube holding rack identified by the reader of the conveyor and the identifier of which has not previously been read by the reader of the at least one inlet of the biological analysis system.

IPC Classes  ?

• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
• B01L 9/06 - Test-tube stands; Test-tube holders
• G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system

Abstract

The invention relates to a method and a device for counting thrombocytes in a sample. It consists in illuminating a sample and acquiring an image thereof by means of an image sensor. A holographic reconstruction algorithm is applied to the acquired image such that a stack of reconstructed images is obtained. Every reconstructed image is representative of an exposing light wave to which the image sensor is exposed. Every reconstructed image undergoes segmentation such as to isolate regions of interest corresponding to one or more thrombocytes. Using every region of interest, the method makes it possible to count the number of thrombocytes in the sample.

IPC Classes  ?

• G01N 15/14 - Electro-optical investigation
• G03H 1/08 - Synthesising holograms
• G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
• G03H 1/04 - Processes or apparatus for producing holograms

Abstract

A biological analysis system comprises at least two biological analysis devices connected to one another by a conveyor defining a closed circuit, each biological analysis device comprising at least one inlet and one outlet for racks of tubes, and at least one exchange region for exchanging racks of tubes with the conveyor, which exchange region is distinct from the inlet and from the outlet. The inlet of at least two biological analysis devices each form an inlet of the biological analysis system for racks of tubes, and the outlet of at least two biological analysis devices each form an outlet of the biological analysis system for racks of tubes. The biological analysis system further comprises a controller designed to command the transfer of a rack of tubes received in the biological analysis system via the conveyor to another biological analysis device according to the operations to be performed on the tubes in that rack and/or according to a respective workload status of the biological analysis devices.

IPC Classes  ?

• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
• G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations

Abstract

The invention relates to a method and an apparatus that allow a fluorescent sample to be examined in two modes: - by fluorescence imaging, wherein the sample is optically conjugated to an image sensor (30); - by unfocused imaging, wherein the image is acquired in an unfocused configuration in relation to a focused position. The image obtained by unfocused imaging can be reconstructed using a holographic reconstruction algorithm such that information about the structure of the sample under examination is obtained.

IPC Classes  ?

• G01N 21/64 - Fluorescence; Phosphorescence
• G03H 1/00 - HOLOGRAPHIC PROCESSES OR APPARATUS - Details peculiar thereto
• G01N 15/14 - Electro-optical investigation
• G01N 21/45 - Refractivity; Phase-affecting properties, e.g. optical path length using Schlieren methods

Abstract

The invention relates to a method for analysing a medium through holographic imaging and to a corresponding imaging system, in which an image (101) of a sample of medium present in an observation chamber illuminated by a light source is acquired by a photosensitive sensor, the method being characterized in that it additionally comprises, after each acquisition, a fault detection phase using the grey levels of the acquired image, this fault detection phase comprising: dividing the acquired image (101) into a predetermined number N of frames (32, 33); for each frame and for the entire image, evaluating a statistical parameter characterizing the distribution of the grey levels in the frame and in the entire image, respectively; calculating a warning factor on the basis of the previously calculated statistical parameters; comparing the obtained warning factor with a predetermined warning threshold and classifying the acquired image as a defective or valid image according to the result of the previous comparison.

IPC Classes  ?

• G01N 15/02 - Investigating particle size or size distribution

Abstract

The invention relates to a clamp for a biological analysis device which comprises a plastic body that comprises a base (12) to which a first outer branch (6), a second outer branch (10) and a central branch (8) are connected, the first outer branch (6) being longer than the second outer branch (10) and said first outer branch (6) and second outer branch (10) being arranged to engage mutually when the clamp is closed. The first outer branch (6) and the second outer branch (10) each have a first recess (34, 40) and a second recess (32, 38) on the portion oriented towards the inside of the body (4), the first recess (34, 40) being further from the base (12). The central branch (8) has two pairs of recesses (44-46; 48-50) each provided on one side and comprising a first recess (46; 50) and a second recess (44; 48), which are homologous with the first recess (34; 40) and the second recess (32; 38), respectively, of the first outer branch (6) and the second outer branch (10), the second recesses (44; 48) being dimensioned so that the first outer branch (6) and the second outer branch (10) come substantially into contact with the central branch (8) when the clamp is closed, the first recesses (34-46; 40-50) then defining therebetween two annular pockets (54; 58), each suitable for clamping a pipe (56; 60) which it receives.

IPC Classes  ?

• F16L 3/227 - Supports for pipes, cables or protective tubing, e.g. hangers, holders, clamps, cleats, clips, brackets specially adapted for supporting a number of parallel pipes at intervals each support having one transverse base for supporting the pipes each pipe being supported by a separate element fastened to the base
• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
• B01L 99/00 - Subject matter not provided for in other groups of this subclass

Abstract

A device for preparing reagent for particle analysis devices comprises an input for the diluent (8), an input for the concentrated reagent (10), a first circuit (4) connected to the diluent (8) input, a second circuit (6) connected to an input for the concentrated reagent (10), and a mixer (14) connected to the first circuit (4) and to the second circuit (6) and arranged to produce a reagent by mixing the diulent and the concentrated reagent. Said device further comprises a heat exchanger (12) connected to the first circuit (4) and to the second circuit (6), upstream from the mixer (14) and downstream from the input for the diluent (8) and the input for the concentrated reagent (10) and designed to create a heat exchange between the diluent from the first circuit (4) and the concentrated reagent from the second circuit (6).

IPC Classes  ?

• G01N 1/38 - Diluting, dispersing or mixing samples

Abstract

A device for shaking and sampling biological liquids that is able to take a sample of a biological liquid in a tube including a shaker designed to mix a rack holding one or more tubes by performing a succession of tilting movements between two shaking positions. The shaker is also arranged to tilt beyond the shaking position furthest away from the insertion position of a rack to discharge same by gravity.

IPC Classes  ?

• G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
• B01F 31/20 - Mixing the contents of independent containers, e.g. test tubes
• B01F 31/23 - Mixing the contents of independent containers, e.g. test tubes by pivoting the containers about an axis
• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor

Abstract

i i P10I0P0I0Ax, y, zii ) depending on the complex expressions calculated during step c).

IPC Classes  ?

• G01N 15/02 - Investigating particle size or size distribution
• G01N 33/49 - Physical analysis of biological material of liquid biological material blood
• G01N 21/45 - Refractivity; Phase-affecting properties, e.g. optical path length using Schlieren methods
• G01N 21/47 - Scattering, i.e. diffuse reflection
• G03H 1/08 - Synthesising holograms
• G01N 15/14 - Electro-optical investigation
• G06T 7/62 - Analysis of geometric attributes of area, perimeter, diameter or volume
• G01N 15/00 - Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
• G03H 1/04 - Processes or apparatus for producing holograms

Abstract

A method for holographic characterization of a particle contained in a sample, based on an image, or hologram, of the sample obtained by an image sensor when the sample is illuminated by a light source. The hologram is the subject of a holographic reconstruction, to obtain a reference complex image, representative of the light wave transmitted by the sample in a reconstruction plane. A holographic propagation operator is applied to the reference complex image, to obtain a plurality of secondary complex images, from which a profile is determined describing the change in an optical feature of the light wave transmuted by the sample along the axis of propagation of the light wave.

IPC Classes  ?

• G01N 15/02 - Investigating particle size or size distribution
• G03H 1/08 - Synthesising holograms
• G01N 15/14 - Electro-optical investigation
• G01N 21/45 - Refractivity; Phase-affecting properties, e.g. optical path length using Schlieren methods
• G03H 1/04 - Processes or apparatus for producing holograms
• G03H 1/00 - HOLOGRAPHIC PROCESSES OR APPARATUS - Details peculiar thereto
• G01N 15/10 - Investigating individual particles

Abstract

A device for agitating and collecting biological liquid samples comprises an agitator of racks of tubes and a sampling apparatus capable of collecting a biological liquid sample in a tube. The device also comprises a scheduler arranged to specify an order of sampling from the tubes independently of the order in which the tubes are positioned in the respective racks and the order in which the racks are inserted into the device. The scheduler is arranged to control the agitator and the sampling apparatus to process the tubes in accordance with the sampling order.

IPC Classes  ?

• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

Abstract

A device for agitating and collecting biological liquid samples comprises an agitator of racks of tubes, a sampling apparatus capable of collecting a biological liquid sample in a tube, and a changer capable of gripping a tube on a rack received in the agitator and moving it to the sampling apparatus. The agitator is capable of agitating at least three racks simultaneously, and the device also comprises a scheduler capable of determining destination data for a tube and destination data for the rack which receives this tube, and of determining for each tube a final location based on the destination data of the tube and the destination data of the racks received in the device, which final location designates a rack, received on the agitator and a position on this rack and can be different from the location of the tube when the rack that received it has been introduced into the device, and arranged to control the changer in order to grip a tube, present it to the sampling apparatus and replace it after sampling at the final location.

IPC Classes  ?

• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
• B01F 29/321 - Containers specially adapted for coupling to rotating frames or the like; Coupling means therefor of test-tubes or the like
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
• G01N 1/00 - Sampling; Preparing specimens for investigation
• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
• B01L 9/06 - Test-tube stands; Test-tube holders
• B65G 65/00 - Loading or unloading
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
• G01N 33/96 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard
• G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system

Abstract

A biological analysis system comprising at least two biological analysis devices (4, 6, 8) connected to each other by a conveyor (10) defining a closed circuit, each biological analysis device () comprising at least one inlet (14, 16, 18) and one outlet (24, 26, 28) for racks (20) of tubes (22), and at least one area for exchanging racks (20) of tubes (22) by means of the conveyor (10), wherein the exchange area is separate from the inlet (14, 16, 18) and from the outlet (24, 26, 28). The inlet (14, 16, 18) of at least two biological analysis devices (4, 6, 8) each forms an inlet of the biological analysis system for racks (20) of tubes (22), and the outlet (24, 26, 28) of at least two biological analysis devices (4, 6, 8) each forms an outlet of the biological analysis system for racks (20) of tubes (22). The biological analysis system (2) further comprises a controller (12) arranged for controlling the transfer of a rack (20) of tubes (22) received in the biological analysis system (2) via the conveyor (10) to another biological analysis device (4, 6, 8) depending on the operations to be performed on the tubes (22) of this rack (20), and/or depending on a respective load state of the biological analysis devices (4, 6, 8).

IPC Classes  ?

• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
• G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system

Abstract

The invention relates to a biological analysis system comprising at least one inlet and one outlet, and at least two biological analysis devices (4, 6, 8) which are interconnected by a conveyor (10) defining a closed circuit, each biological analysis device (4, 6, 8) comprising a region for exchanging holders (20) of tubes (22) with the conveyor (10). The conveyor (10) and the at least one inlet of the biological analysis system comprise a reader for reading the identifier of holders (20) of tubes (22), arranged so as to communicate a read identifier to a controller (12) of the biological analysis system, said controller (12) being arranged so as to apply a specific treatment to a holder (20) of tubes (22) identified by the reader of the conveyor (10), the identifier thereof having not been read previously by the reader of the at least one inlet of the biological analysis system.

IPC Classes  ?

• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
• G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system

Abstract

The invention relates to a method for counting particles, particularly blood cells, in a sample, using a lensless optical imaging device. The sample is arranged between a light source and an image sensor. The sample is illuminated by a light source and an image is acquired by the image sensor, said image sensor being exposed to a light wave called an exposition wave. A digital propagation operator is applied to the acquired image so as to obtain a complex amplitude of the exposition wave according to a surface facing the image sensor. An image, called a reconstructed image, is formed from the modulus and/or the phase of said complex amplitude, on which image the particles to be counted appear in the form of regions of interest. The method then comprises a step of selecting the regions of interest corresponding to the particles to be counted.

IPC Classes  ?

• G01N 15/14 - Electro-optical investigation
• G03H 1/04 - Processes or apparatus for producing holograms
• G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
• G01N 15/00 - Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials

Abstract

The invention relates to a protection device intended to be used in a system for detecting objects of interest dispersed in a sample, said system comprising: - a source (1) of light radiation intended to emit light radiation (10) in a main direction (X); - an image sensor (2); - a transparent display zone (Z) intended to receive said sample and positioned between said source (1) of light radiation and said sensor (2), and said sensor (2) being arranged to acquire an image of the sample on its surface on the basis of radiation transmitted through the display zone by said radiation source; - said device comprising protection means to be interposed between the source (1) of light radiation and said display zone (Z) in order to protect said display zone from the deposition of impurities.

IPC Classes  ?

• G01N 21/45 - Refractivity; Phase-affecting properties, e.g. optical path length using Schlieren methods
• G01N 15/14 - Electro-optical investigation
• G01N 33/483 - Physical analysis of biological material
• G03H 1/04 - Processes or apparatus for producing holograms

Abstract

A method for identifying a state of a cell contained in a sample, including: illuminating the sample using a light source by producing an incident light wave propagating toward the sample; then acquiring, using a matrix-array photodetector, an image of the sample, the sample being placed between the light source and the matrix-array photodetector such that the matrix-array photodetector is exposed to a light wave resulting from interference between the incident light wave and a diffraction wave produced by each cell; applying a numerical reconstruction algorithm to the image acquired by the matrix-array photodetector, to estimate a characteristic quantity of the light wave reaching the matrix-array detector, at a plurality of distances from the matrix-array photodetector. The value of the characteristic quantity, or its variation as a function of distance, allows the state of the cell to be determined from among predetermined states.

IPC Classes  ?

• G01N 15/14 - Electro-optical investigation
• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• G01N 21/45 - Refractivity; Phase-affecting properties, e.g. optical path length using Schlieren methods
• G01N 21/47 - Scattering, i.e. diffuse reflection
• G01N 21/51 - Scattering, i.e. diffuse reflection within a body or fluid inside a container, e.g. in an ampoule
• G03H 1/08 - Synthesising holograms
• G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
• G06T 7/00 - Image analysis
• G03H 1/04 - Processes or apparatus for producing holograms
• G01N 33/483 - Physical analysis of biological material
• G01N 15/10 - Investigating individual particles
• G01N 21/17 - Systems in which incident light is modified in accordance with the properties of the material investigated
• G03H 1/00 - HOLOGRAPHIC PROCESSES OR APPARATUS - Details peculiar thereto
• G01N 15/00 - Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials

Abstract

The invention relates to a method for determining the number of white blood cells in a sample. The method is based on an image, or hologram, of the sample, obtained by an image sensor when the sample is illuminated by a light source. The hologram is reconstructed holographically, such as to obtain a complex image, known as the reference complex image, representing a light wave transmitted by the sample, in a reconstruction plane. A holographic propagation operator is applied to the reference complex image, such as to produce a plurality of so-called secondary complex images, forming a stack of images, from which a profile is determined describing the evolution of an optical characteristic of the light wave transmitted by the sample along the axis of propagation of said light wave. The presence of white blood cells and the number thereof are determined according to the aforementioned profiles.

IPC Classes  ?

• G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
• G01N 15/14 - Electro-optical investigation
• G03H 1/04 - Processes or apparatus for producing holograms
• G03H 1/08 - Synthesising holograms
• G01N 15/10 - Investigating individual particles
• G01N 15/00 - Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials

Abstract

The invention relates to a method for triggering a pulsed light source, wherein it comprises at least one iteration of the following steps: receiving a control signal; determining what is called a separation time between the reception of said control signal and at least one preceding control signal; adjusting at least one control parameter of said pulsed light source depending at least on said separation; generating at least one electrical signal for triggering the pulsed light source depending on said at least one control parameter adjusted during the preceding step; and triggering the pulsed light source depending on said at least one triggering electrical signal.

IPC Classes  ?

• H01S 3/10 - Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating
• G01N 15/14 - Electro-optical investigation
• G01N 15/10 - Investigating individual particles
• H01S 3/102 - Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating by controlling the active medium, e.g. by controlling the processes or apparatus for excitation

Abstract

A device for counting particles comprises a detector arranged to produce an electrical measurement signal in response to the passage of one or more particles, and a comparator arranged to compare the measurement signal with a threshold signal and to increment a counting value when the measurement signal exceeds the threshold signal, characterized in that it furthermore comprises a threshold-adjusting circuit that applies a lowpass filter to the measurement signal, and that is connected to the comparator in order to use the resulting signal as threshold signal.

IPC Classes  ?

• G01N 15/12 - Coulter-counters
• G01N 15/10 - Investigating individual particles

Abstract

A method for identifying a particle contained in a sample, including illuminating the sample using a light source, the light source producing an incident light wave propagating toward the sample, then acquiring, using a matrix-array photodetector, an image of the sample, the sample being placed between the light source and the photodetector such that the matrix-array photodetector is exposed to a light wave that is the result of interference between the incident light wave and a diffraction wave produced by each particle. The method further includes applying a numerical reconstruction algorithm to the image acquired by the photodetector, to estimate a characteristic quantity of the light wave reaching the detector, at a plurality of distances from the detector. The variation in the characteristic quantity as a function of distance allows the particle to be identified.

IPC Classes  ?

• G01N 15/14 - Electro-optical investigation
• G03H 1/08 - Synthesising holograms
• G03H 1/04 - Processes or apparatus for producing holograms
• G01N 21/45 - Refractivity; Phase-affecting properties, e.g. optical path length using Schlieren methods
• G01N 21/47 - Scattering, i.e. diffuse reflection
• G06K 9/00 - Methods or arrangements for reading or recognising printed or written characters or for recognising patterns, e.g. fingerprints
• G06T 7/00 - Image analysis
• G01N 33/49 - Physical analysis of biological material of liquid biological material blood

Abstract

A device for shaking and sampling biological liquids suitable for carrying out a sampling of biological liquids in a tube (14) comprises a shaker (26) suitable for mixing a rack (12) that receives one or more tubes (14) by carrying out a succession of swings between two shaking positions. The shaker (26) is additionally arranged to swing beyond the shaking position furthest from the introduction position of a rack (12) in order to discharge it by gravity displacement.

IPC Classes  ?

• G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
• B01F 11/00 - Mixers with shaking, oscillating, or vibrating mechanisms

Abstract

The invention relates to a method for detecting, by means of flow cytometry, the presence of normal plasma cells and tumoral plasma cells in a sample of cells from a patient.

IPC Classes  ?

• G01N 33/574 - Immunoassay; Biospecific binding assay; Materials therefor for cancer
• G01N 15/14 - Electro-optical investigation
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

Abstract

The invention relates to a method for holographic characterisation of a particle (10b) contained in a sample (10), based on an image (lo), or hologram, of the sample obtained by an image sensor (16) when the sample is illuminated by a light source (11). The hologram is the subject of a holographic reconstruction, in such a way as to obtain a complex image, referred to as the reference complex image (Aref), representative of the light wave transmitted by the sample in a reconstruction plane. A holographic propagation operator is applied to said reference complex image, in such a way as to obtain a plurality of so-called secondary complex images (Aref, z), from which a profile is determined describing the change in an optical feature of the light wave transmitted by the sample along the axis of propagation z of said light wave.

IPC Classes  ?

• G03H 1/04 - Processes or apparatus for producing holograms
• G03H 1/08 - Synthesising holograms
• G01N 21/45 - Refractivity; Phase-affecting properties, e.g. optical path length using Schlieren methods
• G01N 15/14 - Electro-optical investigation

Abstract

The present invention provides a device and computer program that make it possible to more quickly identify the position of a bar code to be read, even when using a rotary drive mechanism in which the rotation angle of a target cannot be accurately known. A control unit 3: controls a rotary drive unit 1 and a bar code reader unit 2; in a first operation, identifies the position of a first region, which is a rough range of a bar code to be read, by a bar code scan at a faster first speed; then, in a second operation, scrutinizes just the first region by a bar code scan at a slower second speed; and identifies the position of a second region, which is a precise range of the bar code to be read. Further, the center part of the second region may be identified and rotated until reaching the reading position of the bar code reader unit.

IPC Classes  ?

• G06K 7/10 - Methods or arrangements for sensing record carriers by corpuscular radiation
• G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
• G06K 7/14 - Methods or arrangements for sensing record carriers by corpuscular radiation using light without selection of wavelength, e.g. sensing reflected white light

Abstract

Provided is a device comprising a driving unit 10 which includes a drive-source device 1 and a drive shaft 2. The drive shaft includes a drive-side roller 3 that rotates an object (specimen container) A1. The drive shaft is provided with a unidirectional transmission device 20 that includes a mechanism by which only a rotation drive force F1 in the first direction of the drive shaft is transmitted to a driven-side portion. The present device includes one of the following: a mechanism which converts the rotation drive force F1 in the first direction, and causes the drive unit 10 to move in a direction of separation from the object; and a mechanism which converts the rotation drive force F1 in the first direction, and causes a driven unit 40 to move in a direction of separation from the object. A second-direction rotation drive force F2 of the drive shaft 2 rotates the object A1.

IPC Classes  ?

• G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
• G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations

Abstract

The invention relates to a tube rack adapter (302) of the type comprising a base which can be inserted into one of the receptacles of the rack and at least two arms (304) extending generally away from the base in a first direction, the arms being arranged so move apart from one another when passing a tube, from an inoperative position to an operative position in which the arms contribute to holding said tube in the receptacle. The adapter also comprises at least one finger (306) resiliently hinged to one of the arms (304) and extending generally in a second direction, substantially opposite the first direction, the finger (306) projecting relative to the arm so as to be separated from the tube when the arms (304) are in the inoperative position and resting against the tube when the arms (304) are in the operative position in order to complete the holding of the tube in the receptacle.

IPC Classes  ?

• B01L 9/06 - Test-tube stands; Test-tube holders
• G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations

Abstract

The invention relates to a device for collecting biological liquid samples, which comprises a sampling member (50, 52) capable of collecting a biological liquid sample in a tube (10) received in a rack (8). The device also includes a changer (34) capable of moving a tube (10) on a rack (8) and a scheduler capable of determining destination data for a tube (10) and arranged to control the changer (34) so as to move a tube (10) held in a rack (8) vertically in accordance with destination data associated with said tube (10).

IPC Classes  ?

• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
• G01N 1/00 - Sampling; Preparing specimens for investigation
• G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system

Abstract

The invention relates to a device for agitating and collecting biological liquid samples, which comprises an agitator (30) of tube (10) racks (8), and a sampling member (51, 52) capable of collecting a biological liquid sample in a tube (10). The device also includes a scheduler arranged to define an order for collecting from the tubes (10) regardless of the order in which the tubes (10) are positioned in the respective racks (8) and of the order in which the racks (8) are inserted into the device (1), and arranged to control the agitator (30) and the sampling member (51, 52) in order to treat the tubes (10) according to this sampling order.

IPC Classes  ?

• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
• G01N 1/00 - Sampling; Preparing specimens for investigation
• G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system

Abstract

The invention relates to a device for agitating and collecting biological liquid samples, which comprises an agitator (30) of tube (10) racks (8), a sampling member (51, 52) capable of collecting a biological liquid sample in a tube (10), and a changer (34) capable of gripping a tube (10) on a rack (8) received in the agitator (30) and of moving same towards the sampling member (51, 52). The agitator (30) is capable of agitating at least three racks (8) simultaneously, and the device also includes a scheduler capable of determining destination data for a tube (10) and destination data for the rack (8) which receives said tube (10), and of determining a final location for each tube (10) in accordance with destination data of the tube (10) and destination data of the racks (8) received in the device, said final location designates a rack (8) received on the agitator (30) and a position on said rack (8) and can be different from the location of the tube (10) when the rack (8) which receives same has been inserted into the device (1), and arranged to control the changer (34) in order to grip a tube (10), present same to the sampling member (51, 52) and replace same after collection at said final location.

IPC Classes  ?

• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
• G01N 1/00 - Sampling; Preparing specimens for investigation
• G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system

Abstract

The invention relates to a sampling valve and to a device equipped with such a valve notably allowing haematology measurements to be taken from a blood sample. The valve comprise two external parts, one internal part clamped between said external parts, and means for regulating the relative angular position of these parts about an axis of rotation. The internal part has opposite surfaces pressing in a sealed and sliding manner against adjacent surfaces of the external parts. The external parts comprise orifices, loops and ducts, said loops and said ducts being arranged in such a way as to communicate selectively with orifices passing through the internal part. The valve parts have no aliquot return groove or recess or labyrinth, thereby eliminating regions of turbulence. The valve is characterized in that two of the parts are able to rotate about the axis of rotation with respect to one of the said parts which is stationary, the rotary parts preferably being the external parts. The sampling valve also makes it possible to form calibrated volumes of a sample taken in the loops and/or the orifices of the internal part.

IPC Classes  ?

• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
• F16K 11/074 - Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves; Arrangement of valves and flow lines specially adapted for mixing fluid with all movable sealing faces moving as one unit comprising only sliding valves with pivoted closure members with flat sealing faces
• F16K 11/16 - Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves; Arrangement of valves and flow lines specially adapted for mixing fluid with two or more closure members not moving as a unit operated by one actuating member, e.g. a handle which only slides, or only turns, or only swings in one plane
• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
• G01N 1/10 - Devices for withdrawing samples in the liquid or fluent state

Abstract

The invention relates to a method for triggering a pulsed light source, characterised in that it comprises at least one iteration of the following steps: receiving a control signal; determining what is called a separation time between the reception of said control signal and at least one preceding control signal; adjusting at least one control parameter of said pulsed light source depending at least on said separation; generating at least one electrical signal for triggering the pulsed light source depending on said at least one control parameter adjusted during the preceding step; and triggering the pulsed light source depending on said at least one triggering electrical signal.

IPC Classes  ?

• H01S 3/10 - Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating
• G01N 15/14 - Electro-optical investigation

Abstract

The invention relates to a device for counting particles, comprising a detector arranged to produce an electrical measurement signal in response to the passage of one or more particles, and a comparator arranged to compare the measurement signal with a threshold signal and to increase a count value when the measurement signal exceeds the threshold signal. The device is characterised in that it also comprises a threshold adjustment circuit which applies a low pass filter to the measurement signal and which is connected to the comparator in order to use the resulting signal as a threshold signal.

IPC Classes  ?

• G01N 15/12 - Coulter-counters
• G01N 15/10 - Investigating individual particles

Abstract

The invention is a method for identifying a particle contained in a sample, including illuminating the sample using a light source, the latter producing an incident light wave propagating toward the sample, then acquiring, using a matrix-array photodetector, an image of the sample, the sample being placed between said light source and the photodetector in such a way that the matrix-array photodetector is exposed to a light wave that is the result of interference between the incident light wave and a diffraction wave produced by each particle. The method is characterised in that it includes applying a numerical reconstruction algorithm to the image acquired by the photodetector, in order to estimate a characteristic quantity of the light wave reaching the detector, at a plurality of distances from the detector. The variation in the characteristic quantity as a function of distance allows the particle to be identified.

IPC Classes  ?

• G01N 15/14 - Electro-optical investigation

Abstract

The present application relates to: (i) a sampler device for taking a sample of biological fluid, which comprises a capillary component, and a base rigidly connected to said capillary component and provided with a first connector capable of being reversibly attached in a leaktight manner to a second connector of a dispensing device; (ii) a dispensing device which also comprises means for transferring diluting fluid which open into said second connector. The application also relates to a biological analysis apparatus implementing the sampler and dispensing devices and to a method for sampling and dispensing a biological fluid.

IPC Classes  ?

• B01L 3/02 - Burettes; Pipettes
• A61B 5/15 - Devices for taking samples of blood
• A61B 5/157 - Devices for taking samples of blood characterised by integrated means for measuring characteristics of blood
• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

Abstract

The invention relates to a sampling valve and to a device equipped with such a valve notably allowing haematology measurements to be taken from a blood sample. The valve comprises two external parts, one internal part clamped between said external parts, and means for regulating the relative angular position of these parts about an axis of rotation. The internal part has opposite surfaces pressing in a sealed and sliding manner against adjacent surfaces of the external parts. The external parts comprise orifices, loops and ducts, said loops and said ducts being arranged in such a way as to communicate selectively with orifices passing through the internal part. The valve parts have no aliquot return groove or recess or labyrinth, thereby eliminating regions of turbulence. The valve is characterized in that two of the parts are able to rotate about the axis of rotation with respect to one of the said parts which is stationary, the rotary parts preferably being the external parts. The sampling valve also makes it possible to form calibrated volumes of a sample taken in the loops and/or the orifices of the internal part.

IPC Classes  ?

• F16K 11/074 - Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves; Arrangement of valves and flow lines specially adapted for mixing fluid with all movable sealing faces moving as one unit comprising only sliding valves with pivoted closure members with flat sealing faces
• F16K 11/14 - Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves; Arrangement of valves and flow lines specially adapted for mixing fluid with two or more closure members not moving as a unit operated by one actuating member, e.g. a handle
• B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
• G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers
• G01N 1/20 - Devices for withdrawing samples in the liquid or fluent state for flowing or falling materials

Abstract

The present invention relates to a method for compensating for the breakdown of a reagent stored in an aqueous phase comprising at least one fluorescent compound and enabling the identification of particles, including the steps of: (i) measuring the fluorescence level FLUOm(t) of particles marked with said reagent; (ii) measuring the absorbance at at least one wavelength of a solution of said reagent, at a time t close to the time of said fluorescence level FLUOm(t) measurements, so as to determine at least one current optical density DO(t) of the reagent; and (iii) calculating a correction of the fluorescent level measurements using said at least one current optical density DO(t) and at least one initial optical density DO(0) of the reagent that has not been broken down. The invention also relates to a biological analysis device implementing the method.

IPC Classes  ?

• G01N 21/64 - Fluorescence; Phosphorescence
• G01N 21/27 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
• G01N 15/14 - Electro-optical investigation
• G01N 33/49 - Physical analysis of biological material of liquid biological material blood
• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
• G01N 15/10 - Investigating individual particles

Goods & Services

Chemical, biological, biochemical and biotechnological reagents and preparations, for medical use or for veterinary use, designed for diagnosis or for in-vitro analysis of blood, urine or biological liquid samples, all these preparations and all these reagents used for hematology, biochemistry, immunology or coagulation. Apparatus and instruments, for medical or veterinary use, designed for in-vitro diagnosis or analysis of blood, urine or biological liquid samples; manipulators, needles and medical devices for these samples associated with the aforesaid apparatus and instruments, all these products for use in the field of hematology, biochemistry, immunology or coagulation.

Goods & Services

Chemical, biological, biochemical and biotechnological reagents and preparations, for medical use or for veterinary use, designed for diagnosis or for in-vitro analysis of blood, urine or biological liquid samples, all these preparations and all these reagents used for hematology, biochemistry, immunology or coagulation

Goods & Services

(1) Chemical, biological, biochemical, biotechnological preparations and reagents, for medical and veterinary use, for the in vitro diagnosis and analysis of blood, urine and biological liquid samples, all these preparations and all these reagents being used in the field of hematology, biochemistry, immunology and coagulation. (2) Apparatus and instruments, for medical and veterinary use, for the in vitro diagnosis and analysis of blood, urine and biological liquid samples; manipulators, needles and medical devices namely blood sample analyzers, blood sample handlers, blood sample needles, syringe needles for these samples in connection with the above apparatus and instruments, all the above goods being used in hematology, biochemistry, immunology and coagulation.

Goods & Services

Chemical, biological, biochemical and biotechnological reagents and preparations, for medical use or for veterinary use, designed for diagnosis or for in-vitro analysis of blood, urine or biological liquid samples, all these preparations and all these reagents used for hematology, biochemistry, immunology or coagulation Apparatus and instruments, for medical or veterinary use, designed for in-vitro diagnosis or analysis of blood, urine or biological liquid samples; needle manipulators, needles, and medical devices, namely blood testing and diagnostic apparatus, for medical purposes, for manipulation of blood, urine or biological liquid samples, all the foregoing goods for use in the field of hematology, biochemistry, immunology or coagulation

Abstract

The subject of the invention is a device for positioning an object in space, comprising at least 4 plates, each one able to move with respect to another of said plates which is contiguous with it along one of the 3 axes of space, it being possible for the movement of one plate with respect to another plate to be guided by a tenon/mortise assembly in which said tenon is secured to one of the plates and its mortise is produced in the other plate, the spatial orientation of each of the tenon/mortise assemblies being different from the other 2 and along one of the 3 axes of space.

IPC Classes  ?

• G01B 5/00 - Measuring arrangements characterised by the use of mechanical techniques
• F16M 11/04 - Means for attachment of apparatus; Means allowing adjustment of the apparatus relatively to the stand
• G01N 15/02 - Investigating particle size or size distribution
• G01N 15/14 - Electro-optical investigation
• G01N 35/08 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis

Abstract

The present application relates to: (i) a sampler device (11) for taking a sample of biological fluid, which comprises a capillary component (13), and a base (14) rigidly connected to said capillary component (13) and provided with a first connector (16) capable of being reversibly attached in a leaktight manner to a second connector (22) of a dispensing device (21); (ii) a dispensing device (21) which also comprises means for transferring diluting fluid (23) which open into said second connector (22). The application also relates to a biological analysis apparatus implementing the sampler and dispensing devices and to a method for sampling and dispensing a biological fluid.

IPC Classes  ?

• A61B 5/15 - Devices for taking samples of blood

Goods & Services

Chemical, biological, biochemical and biotechnological reagents and preparations, for medical use or for veterinary use, designed for diagnosis or for in-vitro analysis of blood, urine or biological liquid samples, all these preparations and all these reagents used for hematology, biochemistry, immunology or coagulation.

Abstract

The present invention concerns a device for analyzing biological parameters from a sample (6) comprising (i) first transferring means (5, 20, 25), (ii) first preparing means (7), (iii) means for measuring cellular components (8), (iv) second preparing means (10, 11, 22, 23, 24) capable of carrying out, on a sample from the first preparing means (7), at least one dilution with an assay reagent (R3) comprising particles functionalized at the surface with at least one ligand specific to at least one analyte of interest, (v) immunodetection measurement means (30, 31) capable of assaying at least one analyte of interest by measuring the aggregation of functionalized particles, said device further comprising (i) second transferring means (4, 21, 22, 26) at least partially separate from the first transferring means (5, 20, 25) and (ii) means for applying a magnetic field (28) capable of causing, by magnetic interaction, an acceleration of the aggregation of said functionalized particles, which comprise magnetic colloidal particles. The invention also concerns a method implemented in said device.

IPC Classes  ?

• G01N 33/49 - Physical analysis of biological material of liquid biological material blood
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
• G01N 1/38 - Diluting, dispersing or mixing samples
• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
• G01N 21/82 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a precipitate or turbidity
• G01N 15/14 - Electro-optical investigation

Abstract

The present invention relates to a flow assay method in a liquid medium for an object (or element) of interest via the formation of aggregates of particles that are surface-functionalized by at least one functionalizing molecule, or receptor, specific for said object of interest.

IPC Classes  ?

• G01N 33/543 - Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

The present invention relates to a method for compensating for the breakdown of a reagent stored in an aqueous phase comprising at least one fluorescent compound and enabling the identification of particles, including the steps of: (i) measuring the fluorescence level FLUOm(t) of particles marked with said reagent; (ii) measuring the absorbance at at least one wavelength of a solution of said reagent, at a time t close to the time of said fluorescence level FLUOm(t) measurements, so as to determine at least one current optical density DO(t) of the reagent; and (iii) calculating a correction of the fluorescent level measurements using said at least one current optical density DO(t) and at least one initial optical density DO(0) of the reagent that has not been broken down. The invention also relates to a biological analysis device implementing the method.

IPC Classes  ?

• G01N 21/27 - Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
• G01N 21/64 - Fluorescence; Phosphorescence
• G01N 15/14 - Electro-optical investigation

Abstract

A device for inspecting a biological fluid, including a channel through which the fluid flows, a first inspection module arranged in a first region of the channel, and a second inspection module arranged in a second region of the channel, the device configured to provide a quantity that is representative of output of the second inspection module. The first inspection module is configured to measure at least one electrical property of the fluid passing through the first region. The second inspection module is configured to measure at least one optical property of the fluid passing through the second region. The inspection device also includes a controller connected to the first inspection module and to the second inspection module and configured to control the second inspection module according to the output of the first inspection module.

IPC Classes  ?

• G01N 15/06 - Investigating concentration of particle suspensions
• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups
• G01N 33/48 - Biological material, e.g. blood, urine; Haemocytometers
• G01N 21/64 - Fluorescence; Phosphorescence
• G01N 15/10 - Investigating individual particles
• G01N 15/14 - Electro-optical investigation
• G02B 27/09 - Beam shaping, e.g. changing the cross-sectioned area, not otherwise provided for

Abstract

"Device for positioning an object in space" Abstract The subject matter of the invention is a device for positioning an object in space comprising at least 4 plates (T1, T2, T3, T4), each capable of moving in relation to one of the other said plates with which it is contiguous along one of the 3 axes of space, the movement of a plate in relation to another plate potentially being guided by a mortise/tenon assembly in which said tenon may be rigidly connected with one of said plates and the mortise thereof may be built into the other plate, the orientation in space of each of the mortise/tenon assemblies being different from the other 2 and along one of the 3 axes of space, characterised in that: Said device is free of all return springs; At least one of the mortise/tenon assemblies may be in a dovetailed shape; A pre-tension aimed at limiting the movement of a plate with respect to another is laterally applied to one of the edges of the tenon of the mortise/tenon assembly, said pre-tension limiting but not preventing the movement of said plates with respect to one another; The movement of at least one plate with respect to another plate may be assured by means of at least one micrometric screw that can act on at least one of the 2 plates that must be moved with respect to one another, said micrometric screw potentially being rigidly connected with one of said 2 plates, said micrometric screw potentially being fastened in direct contact with said plate; The immobilisation of one plate with respect to another plate in the desired position may be assured, independently for each of the mortise/tenon assemblies, by at least one means of immobilisation.

IPC Classes  ?

• G01B 7/00 - Measuring arrangements characterised by the use of electric or magnetic techniques
• G01B 11/00 - Measuring arrangements characterised by the use of optical techniques
• G01B 21/00 - Measuring arrangements or details thereof, where the measuring technique is not covered by the other groups of this subclass, unspecified or not relevant
• B23Q 1/00 - Members which are comprised in the general build-up of a form of machine, particularly relatively large fixed members
• G01B 5/00 - Measuring arrangements characterised by the use of mechanical techniques

Abstract

The present invention concerns a device for analysing biological parameters from a sample (6) comprising (i) first transferring means (5, 20, 25), (ii) first preparing means (7), (iii) means for measuring cellular components (8), (iv) second preparing means (10, 11, 22, 23, 24) capable of carrying out, on a sample from the first preparing means (7), at least one dilution with an assay reagent (R3) comprising particles functionalised at the surface with at least one ligand specific to at least one analyte of interest, (v) immunodetection measurement means (30, 31) capable of assaying at least one analyte of interest by measuring the aggregation of functionalised particles, said device further comprising (i) second transferring means (4, 21, 22, 26) at least partially separate from the first transferring means (5, 20, 25) and (ii) means for applying a magnetic field (28) capable of causing, by magnetic interaction, an acceleration of the aggregation of said functionalised particles, which comprise magnetic colloidal particles. The invention also concerns a method implemented in said device.

IPC Classes  ?

• G01N 1/38 - Diluting, dispersing or mixing samples
• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

Abstract

The invention relates to a method of classifying and flow measuring the refringence of at least two populations of particles present in a fluid. The method uses a light source that has small coherence time, with a coherence length Lc<100 μm, that is used under extinction conditions at a center wavelength selected as a function of a range of volumes and of a range of refractive indices expected for the particles under consideration. The method uses a device that, together with the light source, forms a converging illuminating beam of aperture angle that is selected as a function of the range of volumes and the range of refractive indices expected for the particles under consideration at the selected center wavelength.

IPC Classes  ?

• G01N 15/02 - Investigating particle size or size distribution

Abstract

The invention relates to an electro-optical device for measurements of flow for the characterization of microparticles, comprising a measurement chamber (CM) in which there circulates the flow of the fluid to be characterized, at least two luminous sources (S1, S2) of disjoint spectra, a device for measuring resistivity (RES) and at least three other detectors (D1,D2,D3) each allowing the measurement of an optical parameter, the optical parameters being chosen from among the fluorescence (FL), the extinction (EXT), the diffraction at large angles (SSC) and the diffraction at small angles (FSC).

IPC Classes  ?

• G01N 15/14 - Electro-optical investigation
• G01N 15/02 - Investigating particle size or size distribution
• G01N 21/64 - Fluorescence; Phosphorescence

Abstract

The invention relates to a device for inspecting a biological fluid, including a channel (2) through which the fluid flows, a first inspection module (4) arranged in a first region (10) of said channel (2), and a second inspection module (8) arranged in a second region (12) of said channel (2), said device being arranged to provide a quantity that is representative of the output of the second inspection module (8). The first inspection module (4) is arranged so as to measure at least one electrical property of the fluid passing through the first region (10). The second inspection module (8) is arranged so as to measure at least one optical property of the fluid passing through the second region (12). The inspection device also includes a controller (6) connected to the first inspection module (4) and to the second inspection module (8) and arranged so as to control the second inspection module (8) according to the output of the first inspection module (4).

IPC Classes  ?

• G02B 27/09 - Beam shaping, e.g. changing the cross-sectioned area, not otherwise provided for
• G01N 15/12 - Coulter-counters
• G01N 15/14 - Electro-optical investigation

Goods & Services

Chemical, biological, biochemical, biotechnological preparations and reagents, for medical or veterinary purposes, intended for in vitro analysis or diagnosis of blood, urine or biological liquid samples, all these preparations and all these reagents for use in hematology, biochemistry, immunology or coagulation. Apparatus and instruments, for medical or veterinary use, designed for in vitro analysis or diagnosis of blood, urine or biological liquid samples; medical devices, needles and handling devices for these samples in relation to the above apparatus and instruments, all these goods for use in connection with hematology, biochemistry, immunology or coagulation.

Goods & Services

Apparatus and instruments, for medical or veterinary use, designed for diagnostic in vitro analysis or diagnostic analysis of blood, urine or biological liquid samples; medical devices, namely, blood, urine and other bodily fluid analyzers, and holders, needles and sampling tubes for use therewith, all these goods for use in connection with hematology, biochemistry, immunology or coagulation

Abstract

The invention relates to a method for the flow measurement and classification of the refringence of at least two populations of particles present in a fluid. This method uses a light source of short temporal coherence, having a coherence length Lc < 100 μm, used in extinction mode with a central wavelength chosen according to the expected volume interval and expected refractive index interval of the particles in question. The method uses a device that forms, with the light source, a converging illumination beam with an angular width chosen according to the expected volume interval and expected refractive index interval of the particles in question at the chosen central wavelength. The fluid of particles is then made to flow through a measurement orifice so as to measure impedance variations (RES) as the particles pass therethrough. The fluid of particles flows through the measurement window illuminated by the beam and extinctions (EXT) are measured, on the axis of the beam, as the particles pass through the measurement window by means of a device or a detector, of which the convergent receiving beam having a certain angular width is chosen according to the expected volume interval and expected refractive index interval of the particles in question. The method combines the RES and EXT data to form therefrom events that make it possible to determine a relative refractive index for each of the events and to classify all the events using at least one parameter chosen from RES, EXT or IDX.

IPC Classes  ?

• G01N 15/14 - Electro-optical investigation

Abstract

The present invention relates to a device, to a system, and to a method for the preparation and fractioned dispensing of samples of a fluid. The device of the invention comprises a body having formed therein guide means suitable for receiving a sample-taker member and for guiding it in translation through the device, and at least one preparation chamber enabling an aliquot of a fluid sample dispensed into the chamber by a said sample-taker member to be prepared in a stream of a suitable reagent. The guide means pass through the preparation chamber and communicate therewith to enable an aliquot of fluid to be dispensed into the chamber in a determined position of the sample-taker member in the guide means. The preparation chamber has an introduction orifice for introducing at least one reagent into the chamber for mixing the reagent with an aliquot, and at least one dispensing orifice for dispensing the mixture formed by said aliquot and said reagent to recovery and/or analysis means.

IPC Classes  ?

• B01L 3/02 - Burettes; Pipettes
• B01L 99/00 - Subject matter not provided for in other groups of this subclass
• G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
• G01N 35/08 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

Abstract

The invention relaters to a device (100) for biological analysis by measurement of photoluminescence in a fluid in a measurement tank (111). This device (100) comprises at least two light sources (121, 131) adapted to emit in different spectral areas respectively appropriate for measurement of absorption and fluorescence, and a sensor device (140) comprising a sensor (141), an optical system (142), and filter means (144), which three elements are mutualized in accordance with the invention to enable absorption and/or fluorescence to be measured. In accordance with the invention the internal gain of the sensor (141) is configurable to enable the fluorescence and absorption measurements to be executed sequentially.

IPC Classes  ?

• G01J 1/58 - Photometry, e.g. photographic exposure meter using luminescence generated by light
• G01N 21/00 - Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
• G01N 21/49 - Scattering, i.e. diffuse reflection within a body or fluid

Abstract

The invention relates to a method to be used in an automaton for biological fluid analysis, measuring at least four physical parameters (n>3) for the discriminatory classification and counting of each detected cell into a set of at least three cell classes, and also relates to the representation thereof. According to said method, the following are stored and carried out as needed: mathematical transformations of a plurality of n-uplets into m-uplets, m

IPC Classes  ?

• G01N 15/14 - Electro-optical investigation

Abstract

The invention relates to a biological analysis device (100) for measuring photoluminescence in a fluid present in a measurement cell (111). This device (100) comprises at least two light sources (121, 131) capable of emitting in different spectral ranges, suitable for carrying out absorption and fluorescence measurements respectively, and a detection device (140) comprising a detector (141), an optical system (142) and filtering means (144), these three latter components being mutually designed, according to the invention, to allow the measurement of absorption and/or fluorescence signals. According to the invention, the detector (141) can also be in an internal-gain configuration so as to allow fluorescence measurements and absorption measurements to be carried out sequentially.

IPC Classes  ?

• G01N 15/14 - Electro-optical investigation
• G01N 15/12 - Coulter-counters

Abstract

The invention relates to a valve for sampling a fluid from the same collecting vessel in order to carry out a plurality of analyses using reagents. The valve of the invention includes two members (1, 2) mobile relative to each other, including a so-called sampling member (2) that comprises sampling loops each intended for receiving an aliquot of fluid, and another so-called connection member (1) capable of assuming at least three distinct functional positions relative to the sampling member. These three positions enable the delayed access to two separate sampling circuits for filling the same, and for supplying the loops forming them, with reagents.

IPC Classes  ?

• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
• G01N 1/18 - Devices for withdrawing samples in the liquid or fluent state with provision for splitting samples into portions

Abstract

robotic gripper and displacement means controlled by an automatic controller and suitable for taking hold of and replacing said tubes individually in said storage zone and for conveying them in at least three directions XYZ between said storage zone, said preparation zone and said access zone giving access to said analyzer, said analyzer preferably being connected to and/or controlled by said automatic controller.

IPC Classes  ?

• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor
• G01N 35/04 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations - Details of the conveyor system
• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices

Abstract

The invention relates to a device (1), a system and a method for the preparation and the fractioned dispensing of fluid samples. The device of the invention includes a body (2) in which are formed a guiding means (3) capable of receiving and guiding a sampling member (10) in translation in the device, and at least one preparation chamber (4, 5) for preparing an aliquot of a fluid sample dispensed in the chamber by said sampling organ (10) in a flow of an appropriate reagent. The guiding means (3) extends through the preparation chamber (4, 5) and communicates therewith for dispensing an aliquot of fluid in the chamber upon a predetermined position of the sampling member (10) in the guiding means. The preparation chamber (4, 5) includes an opening (4a, 5a) for inserting at least one reagent into the chamber, for mixing the reagent with the aliquot, and at least one dispensing device (4b, 5b) for dispensing the mixture formed by said aliquot and said reagent towards recovery and/or analysis means (26, 27).

IPC Classes  ?

• G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
• G01N 1/38 - Diluting, dispersing or mixing samples

Abstract

A dedicated polychromatic light generating device including optical pumping devices used to deliver radiation with at least two different excitation wavelengths and a light-guiding device used to deliver polychromatic light at an output when excited by the radiation in a non-linear interaction regime.

IPC Classes  ?

• G02F 2/02 - Frequency-changing of light, e.g. by quantum counters
• H01S 3/10 - Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating

Abstract

The invention concerns a device and a method for measuring photoluminescence in a fluid contained in a measuring vessel [CM]. According to the invention, the fluid in the measuring vessel [CM] receives simultaneously at least two excitation beams from two optical systems [Ci]. Said optical systems [Ci] are positioned so that their axes [Xi] form between them a non-null and separate angle of 180° about the measuring vessel [CM]. A measurement of photoluminescence is deduced according to the invention from a coupling of data obtained from the emission beams captured simultaneously by the capturing elements [CEi]. The optical systems [Ci] are further positioned such that there exists at least one partial overlapping beam [FCba] between the excitation beam and the source [Sb] of a first optical system [Cb] and the emission beam captured by the capturing element [CEa] of a second optical system [Ca]. The device is further provided with at least one so-called capturing element [DTa] in the neighbourhood of at least one of the sources [Sa] to capture a light at the wavelength of excitation in the partial overlapping beam [FCba], a measurement of absorbance and/or of diffraction being deduced from data obtained from said light captured by the attenuating capturing element [DTa].

IPC Classes  ?

• G01N 15/14 - Electro-optical investigation

Abstract

The subject of the invention is a method of discriminating and counting at least two populations of biological elements carrying specific characteristics, possibly present in a specimen. The invention makes it possible for at least three populations of biological elements to be detected unambiguously by using only two detection means. This implies that at least two populations of biological elements are detected by one and the same detection means. The invention may be carried out if three different probes are used, each recognizing and being fixed onto one of the populations of biological elements to be detected, each of the probes itself being made detectable by a different marker, two of said different markers exhibiting two emission spectra having at least one common part (overlapping emission spectra) and a third marker exhibiting an emission spectrum essentially not having any part common with the other two (non-overlapping spectrum).

IPC Classes  ?

• G01N 33/569 - Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
• G01N 33/58 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
• G01N 15/14 - Electro-optical investigation

Abstract

The invention relates to a modular device (100) which is intended for use in a biological fluid analysis system. The inventive device consists of functional modules (101, 102) which each comprise a support for supporting hydraulic components (103, 104, 105), said support including at least two plates (101' and 101', 102' and 102') containing etched circuits which define channels when the two plates are assembled side by side. According to the invention, the functional modules comprise at least a first functional preparation module (101) which is used to prepare the fluid to be analysed and which is equipped with at least one dilution tank (103) and a second functional injection module (102) which is used to inject the fluid prepared in the dilution tank (103) into an analysis unit, said first (101) and second (102) functional modules being connected to one another.

IPC Classes  ?

• G01N 1/38 - Diluting, dispersing or mixing samples

Abstract

The invention concerns a method for preparing total blood sample analyses and a device (1) for implementing said method, said samples being preserved in tubes (3) comprising at least one means for identifying (8) the sample, said device comprising: at least one compartment forming the storage zone (6, 11, 12) for said tubes (3, 19, 23) before and after analysis, and at least one means for reading (9) said identifying means (8) of said tubes; and at least one zone for preparing (10) said blood samples prior to analysis including means (14, 15, 16, 17, 18) for verifying and/or processing said tubes (3, 19, 23) containing said samples, in particular at least one means for stirring (14) said tubes, and at least one zone for accessing (13a, 13b) at least one automatic analyzer (28, 30) on total blood, said access zone enabling one said tube (3, 19, 23) to be placed in said analyzer, and robotized gripping and displacing means (24, 25, 26, 27) controlled by a control automaton (5) and adapted to grip and set down said tubes (3, 19, 23) individually in said storage zone (6, 11, 12) and transport same in at least three directions XYZ between said storage zone, said preparation zone (10) and said access zone (13a, 13b) to said analyzer, said analyzer (28, 30) being preferably connected to and/or controlled by said control automaton (5).

IPC Classes  ?

• G01N 1/00 - Sampling; Preparing specimens for investigation
• G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups ; Handling materials therefor

Abstract

A quality control device for a blood analyzer using whole blood, which specifically can be used to check the correct operation of the blood analyzer. The device includes a storage for storing control bloods by cooling; a mechanism for bringing the control bloods back to the temperature specified by the control blood manufacturer; a stirring mechanism used for resuspension of the cells; and a mechanism for sampling the blood thus prepared.

IPC Classes  ?

• G01N 33/00 - Investigating or analysing materials by specific methods not covered by groups

Abstract

The invention concerns a device (DA) for analyzing microscopic elements, comprising firstly a measuring space (CM) for microscopic elements to be analyzed, secondly at least one source (S) delivering conjugated rays at the measuring space (CM), having at least two different analyzing wavelengths and designed to interact with the microscopic elements in the measuring space (CM) to form interacting rays, thirdly coding means (M) for encoding the rays upstream of the measuring space (CM) with different codes, fourthly optical filtering means (FO) for selectively filtering the interacting rays of fluorescence and/or diffusion depending on their wavelength, fifthly detecting means (DE, DF) for transforming into electric signals part at least of the interacting rays from the measuring space (CM), and sixthly analyzing means (MA) including decoding means (DRE, DRF) for decoding the electric signals to enable data representing the analyzed microscopic elements to be determined.

IPC Classes  ?

• G01N 15/02 - Investigating particle size or size distribution

Goods & Services

Chemical preparations and reagents for in vitro diagnosis, for medical use; chemical preparations and reagents for the laboratory analyses, for medical use, all these goods being exclusively used in haemoatology.

Goods & Services

Chemical preparations and reagents for in vitro diagnosis, for medical use; chemical preparations and reagents for laboratory analyses, for medical use; all these products being exclusively used in haematology.

Goods & Services

Chemical preparations and reagents for in vitro diagnostics, for medical use; diagnostic preparations and reagents for clinical or medical laboratory use in the field of hematology, all of these products being exclusively used in hematology

Goods & Services

Chemical preparations and reagents for in vitro diagnostics, for medical use; diagnostic preparations and reagents for clinical or medical laboratory use in the field of hematology, all of these products being exclusively used in hematology

Goods & Services

(1) Chemicals and reagents used for medical in vitro diagnostic in the field of haematology; chemicals and reagents for clinical and medical laboratory use in the field of haematology.