Abstract

A useful and novel aromatic amino acid derivative which is soluble in water, has a selective inhibitory activity against LAT1 that is specifically expressed in a cancer cell, and has a high cancer cell growth inhibitory activity, an LAT1 inhibitor containing the same and a method for producing the same.

IPC Classes  ?

• C07D 263/54 - BenzoxazolesHydrogenated benzoxazoles
• A61K 31/423 - Oxazoles condensed with carbocyclic rings
• A61K 31/4427 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems
• A61K 31/4439 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
• A61P 35/00 - Antineoplastic agents
• A61P 43/00 - Drugs for specific purposes, not provided for in groups
• C07D 413/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring- member bond