A high-pressure fluid handling device. The high-pressure fluid handling device includes a housing, a tube, and a stationary phase medium. The housing includes a first component with a first interface surface and a second component with a second interface surface. The first and second components are securable to one another with the first and second interface surfaces in facing relationship with one another to form an interface therebetween. The housing includes a channel extending through the first component to and along the interface. The tube extends along the channel. The tube defines a lumen with a substantially circular cross-section having a lumen diameter equal to or less than 1000 μm. The stationary phase medium is positioned in the lumen. The stationary phase medium is suitable to chromatographically separate compounds present in a liquid sample.
G01N 30/22 - Injection in high pressure liquid systems
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
A method for sampling a liquidous material with a sampling system includes providing the sampling system having a gas/liquid separator. The gas/liquid separator includes a separation chamber having a membrane separating the separation chamber into a retentate portion and a permeate portion. The membrane is gas-permeable and liquid impermeable. The gas/liquid separator includes a pressure regulation system fluidically connected to the permeate portion of the separation chamber. The pressure regulation system is configured to control a gas pressure in the permeate portion. The method includes selectively operating the pressure regulation system in a first mode and a second mode. The first mode establishes a first gas pressure condition in the permeate portion of the separation chamber configured to draw a sample of the liquidous material from a reservoir through a first flow channel to the retentate portion of the separation chamber. The second mode establishes a second gas pressure condition in the permeate portion of the gas/liquid separation chamber to push the sample from the retentate portion of the separation chamber through the first flow channel toward the reservoir.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Optical components and instruments, namely, optical filters, optical mirrors, optical dichroic and polychroic filters, attenuators and antireflection coatings for optical lenses, optical assemblies in the nature of optical lens units composed of any of a combination of optical filters, optical mirrors, optical lasers and optical sensors and optical modules in the nature of optical transceivers Design services for others in the field of optical components; Providing online, non-downloadable software in the field of optical component design, namely, software to create simulations and optimizations of optical filters, optical mirrors, optical dichroic and polychronic filters; Providing temporary use of on-line non-downloadable software and applications for plotting and analyzing spectral performance of fluorophores, optical filters and optical lighting sources; Providing online, non-downloadable software for analyzing and selecting fluorescence microscopy, fluorescent dyes, light sources and detectors
Chromatography apparatus for laboratory use; fittings and connections for use in the field of chromatography, namely, fittings and connections for chromatography apparatuses for laboratory use; gas chromatography apparatus for laboratory use; plug connectors; fittings and accessories specially adapted for use with chromatography apparatus for laboratory use, namely, press-fit ferrules and lock-ring connectors
Various embodiments of a laser illumination system are disclosed. In some examples, a system includes one or more lasers and a beam combiner configured to direct a combined light beam along a path. The system can include a polychroic optical assembly that receives the combined light beam and to output a first beam of the first light of the first wavelength and a second beam of the second light of the second wavelength. The second beam can be offset from the first beam. The polychroic optical assembly can be a prism assembly. The system can include one or more optical elements configured alter a distribution of light of the first beam to output a first output line at a sample plane, and to alter a distribution of light of the second beam to output a second output line at the sample plane.
09 - Scientific and electric apparatus and instruments
Goods & Services
Pressure fittings and ferrules for laboratory equipment and apparatus in the nature of DNA sequencers, tubing assemblies therefor and sipper probes apparatus, for laboratory use
A magnetic particle suspension system includes a vessel defining a chamber and an opening to the chamber, particles magnetically responsive to a magnetic field disposed in the chamber, and a suspension apparatus for controllably moving the magnetic field along a path having an engagement portion in which the magnetic field effects a magnetic response in the particles, wherein the suspension apparatus includes a motor, an arm movably driven by the motor, and a magnet supported by the arm for movement along the path, wherein the motor rotatably drives the arm about a drive axis so that the magnet travels along a circumaxial path about the drive axis.
A fluid immersion control system may use a common electrode along with a plurality of sensor electrodes at a distal portion of an immersion microscope objective to monitor electrical resistance of a fluid as an indication of presence of a fluid layer used for immersion microscopy. The fluid immersion control system may activate replenishment of the fluid when the resistance indicates that a diameter of the microscope objective is not immersed in the fluid.
A method for processing a sample of a cell culture composition includes diluting the sample followed by filtering the diluted sample, wherein the dilution may be at least 10 parts by volume of a diluent to one part sample, and the filter may be a porous membrane with a molecular weight cutoff of less than 20,000 Daltons. The dilution may be carried out at a multiple-port dilution valve having a first condition and a second condition. The sample may be mixed with the diluent at a predetermined dilution ratio when the dilution valve is in the second condition.
An apparatus is described for controlling fluid flow and in particular fluid flow through a microfluidic multi-port control valve assembly of a High Pressure Liquid Chromatography (HPLC) unit. The flow control apparatus has a localized data repository for storing cumulative wear indications of components of the apparatus. The stored information travels with the apparatus allowing for more reliable predictive failure of components of the apparatus.
F16K 31/04 - Operating means; Releasing devices magnetic using a motor
F16K 37/00 - Special means in or on valves or other cut-off apparatus for indicating or recording operation thereof, or for enabling an alarm to be given
G05B 21/02 - Systems involving sampling of the variable controlled electric
42 - Scientific, technological and industrial services, research and design
Goods & Services
Platform as a service (PAAS) featuring computer software platforms for plotting and analyzing spectral performance of fluorophores, optical filters and optical lighting sources; Providing temporary use of a non-downloadable web application for plotting and analyzing spectral performance of fluorophores, optical filters and optical lighting sources; Providing temporary use of on-line non-downloadable software and applications for plotting and analyzing spectral performance of fluorophores, optical filters and optical lighting sources
16.
LASER SYSTEMS AND OPTICAL DEVICES FOR LASER BEAM SHAPING
Various embodiments of a laser illumination system are disclosed. In an example, a system includes one or more lasers, a beam combiner (if multiple lasers are used) configured to direct a combined light beam along a path, a focusing optical element to receive the light beam and focus the received light towards a focus point, a MEMS mirror positioned to receive light from the focusing optical element and output a moving light beam, moving in an angular range ar1 and at a frequency f1, a collimating element configured to receive the beam output by the MEMS mirror and output a beam that is more collimated than the light received from the MEMS mirror, and a CLA positioned to receive the light beam from the collimating optical element, alter the received light beam, and output a substantially flat-top distribution of light that propagates through an objective lens to a target plane.
G02B 26/08 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
09 - Scientific and electric apparatus and instruments
Goods & Services
complementary metal oxide semiconductor (CMOS) imaging sensors and cameras, all for the life sciences research industry; complementary metal oxide semiconductor (CMOS) imaging sensors and cameras not for medical purposes, all for the life sciences industry
09 - Scientific and electric apparatus and instruments
Goods & Services
Optical filters for use in lasers and optical systems in the life sciences and analytical instrumentation markets; scientific and technical apparatus, namely, optical mirrors
A multiple channel selector valve includes a stator and a rotor that is rotatable with respect to the stator. The rotor face includes first and second fluid flow paths for transferring fluids to selected sets of passages in the stator. The fluid flow paths in the rotor face are specifically configured to accommodate high fluid flow rate regimes while reducing flow restriction.
F16K 11/074 - Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves; Arrangement of valves and flow lines specially adapted for mixing fluid with all movable sealing faces moving as one unit comprising only sliding valves with pivoted closure members with flat sealing faces
The invention relates to a flow cell with a predetermined breaking barrier in a duct region (6, 7, 14, 71) of the flow cell. The flow cell according to the invention is characterized by a cut-out (7) in a substrate (1) of the flow cell, which forms a portion of the duct region (6, 7, 14, 7 ') and has an opening in a surface of the substrate (1), wherein the opening is hermetically sealed by a barrier film (8) fused and/or glued to the surface and forming the predetermined breaking barrier, and by a layer (9) provided to be arranged over the barrier film (8), which layer can be stretched into the cut-out (7) on breaking of the barrier film (8) and formation of an access to a duct region section (14) bounded by the barrier film (8) and the layer (9).
09 - Scientific and electric apparatus and instruments
Goods & Services
Filters for optical devices; Optical filters; Optical filters for screens, all the foregoing for spectrograph devices; Filters for optical devices; Optical filters; Optical filters for screens, all the foregoing for life sciences analytical and research devices
A fluid immersion control system may use a common electrode along with a plurality of sensor electrodes at a planar surface associated with a distal end of an immersion microscope objective to monitor electrical resistance of a fluid as an indication of presence of a fluid layer having a meniscus greater than a diameter of an optical axis used for immersion microscopy. The fluid immersion control system may activate replenishment of the fluid when the resistance indicates that the diameter is not immersed in the fluid.
A structural reinforcement and biocompatible pump head for a pump includes a reinforcement structure having a plurality of ports and fluid pathways therein. The fluid pathways in the reinforcement may be coated or lined with a biocompatible material to form a biocompatible pump head useful for liquid chromatography and other analytical instrument systems. The biocompatible material may be injection molded into the fluid pathways of the reinforcement structure and may be machined after core pins are removed to obtain a desired surface finish and/or size of the biocompatible fluid pathways of the pump head.
An apparatus for controlling fluid flow, and in particular fluid flow through a microfluidic multi-port control valve assembly of a High Pressure Liquid Chromatography (HPLC) unit includes a localized data repository for storing cumulative wear indications of components of the apparatus. The stored information may travel with the apparatus to enable predictive failure of components of the apparatus.
F16K 31/04 - Operating means; Releasing devices magnetic using a motor
F16K 37/00 - Special means in or on valves or other cut-off apparatus for indicating or recording operation thereof, or for enabling an alarm to be given
The pressure fluctuations in a fluid degassing system may be diminished by independently controlling the intake phase and the exhaust phase of an evacuation pump. The speed of the pump's drive element may be modulated at least during the intake phase to more closely align with a pressure set point in a degassing module.
A valve for use with liquid chromatography or other analytical systems may include a separate and removable stator plate. The stator plate may be a with a multi-piece stator plate with different layers. A mounting device mounting device may be adapted to engage the stator plate. The mounting plate may include a plurality of ports for fluidic connections in fluid communication with fluid passageways in the stator plate. Liquid chromatography elements, such as a packed chromatography column, a sample loop, or an electronic device may be formed on one or more layers of the stator plate. A first stator plate may be removed from a valve and replaced by a second stator having additional or different liquid chromatography elements than the first stator plate.
F16K 31/04 - Operating means; Releasing devices magnetic using a motor
F16K 25/00 - VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING - Details relating to contact between valve members and seats
F16K 11/074 - Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves; Arrangement of valves and flow lines specially adapted for mixing fluid with all movable sealing faces moving as one unit comprising only sliding valves with pivoted closure members with flat sealing faces
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
The invention relates to a system for transferring a sample from a sample recovery or provision device (3) to a microfluidic processing device (1), more particularly an analysis device, preferably in the form of a flow cell, with a sample carrier (2) that removes the sample (4) from the sample recovery or provision device (3) and can be transported to the processing device (1). According to the invention, the sample carrier (2) can be connected to the sample recovery or provision device (3) and can be detached from sample recovery or provision device (3), with the sample being automatically removed. The sample carrier (2) connected to the sample recovery or provision device (3) is preferably a functional component of the sample recovery or provision device (3), more particularly the sample carrier (2) closes a container space of the sample recovery or provision device (3) for receiving sample material.
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
B81B 1/00 - Devices without movable or flexible elements, e.g. microcapillary devices
A61J 1/05 - Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids
09 - Scientific and electric apparatus and instruments
Goods & Services
Chromatography apparatus for laboratory use; Chromatography columns for laboratory use; Chromatography apparatus for laboratory use, namely, plug connectors, fittings and seals being specially adapted for chromatography apparatuses for laboratory use; Scientific and technical apparatus, namely, plug connectors, fittings and seals being specially adapted for chromatography apparatuses for laboratory use; Scientific and technical apparatus, namely, plug connectors, fittings and seals; Gas chromatography apparatus for laboratory use; Liquid chromatography apparatus for laboratory use; Non-metal tubing and tubing connectors for joining ports and tubes in laboratory equipment and devices, namely, spinal crew connectors
A membrane-based fluid degassing system is arranged for automated control to a degassing efficiency set point, so that fluid is degassed only as necessary. The control variable may be assigned as the degassing environment, to provide the gas transfer driving force suitable to appropriately degas the fluid. By avoiding unnecessary degassing of the fluid, mobile phase pervaporation through the membrane is minimized.
B01D 15/16 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
A multiple channel selector valve includes a stator and a rotor that is rotatable with respect to the stator. The rotor face includes first and second fluid flow paths for transferring fluids to selected sets of passages in the stator. The fluid flow paths in the rotor face are specifically configured to accommodate high fluid flow rate regimes while reducing flow restriction.
F16K 11/074 - Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves; Arrangement of valves and flow lines specially adapted for mixing fluid with all movable sealing faces moving as one unit comprising only sliding valves with pivoted closure members with flat sealing faces
A chromatography column has a column assembly that further includes a column jacket tube and a column liner tube. The column assembly is configured with end fittings that have compression limiting features and are able to withstand very high pressure, such as used in UHPLC, in conjunction with flange portions of the column liner tube that seal the column assembly. The column liner tube may be biocompatible and may have a smooth consistent inner diameter of less than 2 mm, and an. inner diameter of 1 mm in particular embodiments. The end fittings for the microtube assembly may ensure durability and reliability by preventing over- or under-tightening.
Various embodiments of a multi-laser system are disclosed. In some embodiments, the multi-laser system includes a plurality of lasers, a plurality of laser beams, a beam positioning system, a thermally stable enclosure, and a temperature controller. The thermally stable enclosure is substantially made of a material with high thermal conductivity such as at least 5 W/(m K). The thermally stable enclosure can help maintain alignment of the laser beams to a target object over a range of ambient temperatures. Various embodiments of an optical system for directing light for optical measurements such laser-induced fluorescence and spectroscopic analysis are disclosed. In some embodiments, the optical system includes a thermally conductive housing and a thermoelectric controller, a plurality of optical fibers, and one or more optical elements to direct light emitted by the optical fibers to illuminate a flow cell. The housing is configured to attach to a flow cell.
G02B 26/08 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
H01S 3/23 - Arrangement of two or more lasers not provided for in groups , e.g. tandem arrangement of separate active media
Various claims of a multi-laser system are disclosed. In some claims, the multi-laser system includes a plurality of lasers, a plurality of laser beams, a beam positioning system, a thermally stable enclosure, and a temperature controller. Various claims of an optical system for directing light for optical measurements such laser-induced fluorescence and spectroscopic analysis are disclosed. In some claims, the optical system includes a beam shaping element configured to generate an illumination profile having a flat top.
An optical shutter apparatus for controllably blocking an aperture, the shutter apparatus having a rotary actuator configured to rotate a shaft about an axis from a closed-shutter angular position toward an open-shutter angular position and a shutter blade coupled to the shaft and extending along a plane that is in parallel with the axis of rotation, wherein a surface of the shutter blade is reflective. There is a ferromagnetic collar coupled to the shaft and having a protruding portion extending orthogonally from the shaft with respect to the axis. A stationary magnet is disposed to attract the protruding portion of the collar and urge the shaft toward the closed-shutter angular position.
G02B 26/04 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the intensity of light by periodically varying the intensity of light, e.g. using choppers
09 - Scientific and electric apparatus and instruments
Goods & Services
Chromatography columns; Chromatography apparatus for laboratory use; Automatic chromatography apparatus for laboratory use; Liquid chromatography columns for scientific use; Liquid chromatography apparatus for laboratory use; Chromatography instruments for scientific or laboratory use; chromatography connectors, tubing and plugs for laboratory use.
37.
High pressure valve with two-piece stator assembly
Valve with two-piece stator assembly for use with liquid chromatography or other analytical systems. A separate and removable stator plate is provided with a mounting device to provide a two-piece stator assembly. The mounting device is adapted on one side to engage and contact the stator plate, and on the other side includes a plurality of ports for fluidic connections which are in fluid communication with fluid passageways in the stator plate.
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
F16K 11/074 - Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves; Arrangement of valves and flow lines specially adapted for mixing fluid with all movable sealing faces moving as one unit comprising only sliding valves with pivoted closure members with flat sealing faces
F16K 31/04 - Operating means; Releasing devices magnetic using a motor
G01N 30/22 - Injection in high pressure liquid systems
42 - Scientific, technological and industrial services, research and design
Goods & Services
design, development, and consulting services related thereto in the field of life science instruments that use fluidic, laser and optical technologies and solutions; engineering design services; scientific and technological services, namely, research and design in the field of fluidic, laser and optical technologies and solutions; providing a web site that gives computer users the ability to upload and share user-generated videos, essays and articles in the field of scientific and laboratory technologies; providing technological and scientific information, consulting and design in the field of optical and fluidic devices and applications, namely, laboratory equipment fittings, polymers, high-performance liquid chromatography, chemical compatibility, chromatography equipment and micro pumps
A membrane gas-liquid contactor is arranged to define a fluid flow path for contact with a membrane in a manner to improve degassing efficiency. A degassing module housing the membrane is arranged with flow fields for distributing the fluid flow throughout the membrane contact area. The distributed fluid flow may have a uniform membrane contact opportunity.
B01D 15/16 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
09 - Scientific and electric apparatus and instruments
Goods & Services
Chromatography apparatus for laboratory use; fittings and connections for use in the field of chromatography, namely, fittings and connections for chromatography apparatuses for laboratory use; gas chromatography apparatus for laboratory use; plug connectors
The invention relates to a microfluidic flow cell for carrying out an analysis, having a substrate (1) of synthetic material, which has cavities for the formation of channel structures and chambers, wherein the cavities are closed on one side of the substrate (1) by a film (3) adhesively bonded or welded to the substrate (1), and having a housing component (2) that is produced with a hard and a soft component, which, on the side of the substrate (1) facing away from the film (3), is connected to the substrate (1), completing functional sections respectively fulfilling the function of the flow cell. According to the invention, the housing component (2) is formed as a multifunctional part completing more than two functional sections.
An apparatus is described for controlling fluid flow and in particular fluid flow through a microfluidic multi-port control valve assembly of a High Pressure Liquid Chromatography (HPLC) unit. The flow control apparatus has a localized data repository for storing cumulative wear indications of components of the apparatus. The stored information travels with the apparatus allowing for more reliable predictive failure of components of the apparatus.
Various embodiments of a multi-laser system are disclosed. In some embodiments, the multi-laser system includes a plurality of lasers, a plurality of laser beams, a beam positioning system, a thermally stable enclosure, and a temperature controller. The thermally stable enclosure is substantially made of a material with high thermal conductivity such as at least 5 W/(m K). The thermally stable enclosure can help maintain alignment of the laser beams to a target object over a range of ambient temperatures. Various embodiments of an optical system for directing light for optical measurements such laser-induced fluorescence and spectroscopic analysis are disclosed. In some embodiments, the optical system includes a thermally conductive housing and a thermoelectric controller, a plurality of optical fibers, and one or more optical elements to direct light emitted by the optical fibers to illuminate a flow cell. The housing is configured to attach to a flow cell.
G02B 26/08 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
H01S 3/23 - Arrangement of two or more lasers not provided for in groups , e.g. tandem arrangement of separate active media
An optical apparatus has an optic having a first flat surface and a second surface opposite the first flat surface. A frame has a first fixed contact point, a second fixed contact point, and a third fixed contact point that extend from the frame. The first surface of the optic seats against the first, second, and third fixed contact points. A clamping plate applies a three-point nesting force by extending, against the second flat surface of the optic, a first opposing contact point aligned with the first fixed contact point, a second opposing contact point aligned with the second fixed contact point, and a third opposing contact point aligned with the third fixed contact point.
A structural reinforcement and biocompatible pump head for a pump includes a reinforcement structure having a plurality of ports and fluid pathways therein. The fluid pathways in the reinforcement may be coated or lined with a biocompatible material to form a biocompatible pump head useful for liquid chromatography and other analytical instrument systems. The biocompatible material may be injection molded into the fluid pathways of the reinforcement structure and may be machined after core pins are removed to obtain a desired surface finish and/or size of the biocompatible fluid pathways of the pump head.
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
G01N 30/00 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
46.
Biocompatible component with structural reinforcement
A structural reinforcement and biocompatible pump head for a pump includes a reinforcement structure having a plurality of ports and fluid pathways therein. The fluid pathways in the reinforcement may be coated or lined with a biocompatible material to form a biocompatible pump head useful for liquid chromatography and other analytical instrument systems. The biocompatible material may be injection molded into the fluid pathways of the reinforcement structure and may be machined after core pins are removed to obtain a desired surface finish and/or size of the biocompatible fluid pathways of the pump head.
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
F04B 37/12 - Pumps specially adapted for elastic fluids and having pertinent characteristics not provided for in, or of interest apart from, groups for special use to obtain high pressure
F04B 15/00 - Pumps adapted to handle specific fluids, e.g. by selection of specific materials for pumps or pump parts
B29C 45/00 - Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
B29C 45/14 - Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor incorporating preformed parts or layers, e.g. injection moulding around inserts or for coating articles
A valve for use with liquid chromatography or other analytical systems may include a separate and removable stator plate. The stator plate may be a with a multi-piece stator plate with different layers. A mounting device mounting device may be adapted to engage the stator plate. The mounting plate may include a plurality of ports for fluidic connections in fluid communication with fluid passageways in the stator plate. Liquid chromatography elements, such as a packed chromatography column, a sample loop, or an electronic device may be formed on one or more layers of the stator plate. A first stator plate may be removed from a valve and replaced by a second stator having additional or different liquid chromatography elements than the first stator plate.
F16K 31/04 - Operating means; Releasing devices magnetic using a motor
F16K 25/00 - VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING - Details relating to contact between valve members and seats
F16K 11/074 - Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves; Arrangement of valves and flow lines specially adapted for mixing fluid with all movable sealing faces moving as one unit comprising only sliding valves with pivoted closure members with flat sealing faces
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
48.
Method, apparatus, and computer-readable medium for switching optical paths
Presented is a method, apparatus, and computer-readable medium for selectively switching optical paths. The apparatus includes a directing mirror for redirecting light from an incoming path to one of a plurality of input paths and redirecting the light from one of a plurality of output paths to an outgoing path, and a plurality of input mirrors, each one of the plurality of input mirrors operable for redirecting the light from one of the plurality of input paths to one of a plurality of transition paths. The apparatus includes a plurality of light modifying elements, each one of the light modifying elements in a corresponding transition path and a plurality of output mirrors, each one of the plurality of output mirrors operable for redirecting the light from one of the plurality of transition paths to one of a plurality of output paths.
G02B 26/08 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
G02B 21/16 - Microscopes adapted for ultraviolet illumination
G02B 21/18 - Arrangements with more than one light-path, e.g. for comparing two specimens
G02B 26/00 - Optical devices or arrangements for the control of light using movable or deformable optical elements
The invention relates to an arrangement consisting of a plurality of carrier elements (1) for a reagent, which is to be introduced into a microfluidic device, in particular a flow cell, via the carrier element (1), and consisting of a holder (2) receiving the plurality of carrier elements (1). According to the invention, the carrier element (1) is fixed by positive fit in all spatial directions by the holder (2), keeping at least one region (5) of the carrier element (1) which receives the reagent clear.
Valve with multi-piece stator assembly for use with liquid chromatography or other analytical systems. A separate and removable stator plate is provided with a mounting device to provide a multi-piece stator assembly. The mounting device is adapted on one side to engage and contact the stator plate, and on the other side includes a plurality of ports for fluidic connections which are in fluid communication with fluid passageways in the stator plate. By making the stator face a separate component, the overall costs of the valve can be reduced, different materials can be used for the mounting device and the stator, and the valve can be used for ultra-high pressure applications, including in liquid chromatography and other analytical instrument systems.
G01N 30/00 - Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
F16K 11/074 - Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves; Arrangement of valves and flow lines specially adapted for mixing fluid with all movable sealing faces moving as one unit comprising only sliding valves with pivoted closure members with flat sealing faces
F16K 31/04 - Operating means; Releasing devices magnetic using a motor
F16K 27/06 - Construction of housings; Use of materials therefor of taps or cocks
F16K 27/00 - Construction of housings; Use of materials therefor
F16K 5/08 - Taps or cocks comprising only cut-off apparatus having at least one of the sealing faces shaped as a more or less complete surface of a solid of revolution, the opening and closing movement being predominantly rotary - Details
F16K 3/18 - Gate valves or sliding valves, i.e. cut-off apparatus with closing members having a sliding movement along the seat for opening and closing with flat sealing faces; Packings therefor with special arrangements for separating the sealing faces or for pressing them together by movement of the closure members
F16K 5/14 - Special arrangements for separating the sealing faces or for pressing them together
F16K 5/00 - Taps or cocks comprising only cut-off apparatus having at least one of the sealing faces shaped as a more or less complete surface of a solid of revolution, the opening and closing movement being predominantly rotary
Valve with two-piece stator assembly for use with liquid chromatography or other analytical systems. A separate and removable stator plate is provided with a mounting device to provide a two-piece stator assembly. The mounting device is adapted on one side to engage and contact the stator plate, and on the other side includes a plurality of ports for fluidic connections which are in fluid communication with fluid passageways in the stator plate. By making the stator face a separate component, the overall costs of the valve can be reduced, different materials can be used for the mounting device and the stator, and the valve can be used for ultra-high pressure applications, including in liquid chromatography and other analytical instrument systems.
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
F16K 11/074 - Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves; Arrangement of valves and flow lines specially adapted for mixing fluid with all movable sealing faces moving as one unit comprising only sliding valves with pivoted closure members with flat sealing faces
F16K 31/04 - Operating means; Releasing devices magnetic using a motor
G01N 30/22 - Injection in high pressure liquid systems
54.
HIGH PRESSURE VALVE WITH MULTI-PIECE STATOR ASSEMBLY
Valve with multi-piece stator assembly for use with liquid chromatography or other analytical systems, A separate and removable stator plate is provided with a mounting device to provide a multi-piece stator assembly. The mounting device is adapted on one side to engage and contact the stator plate, and on the other side includes a plurality of ports for fluidic connections which are in fluid communication with fluid passageways in the stator plate. By making the stator face a separate component, the overall costs of the valve can be reduced, different materials can be used for the mounting device and the stator, and the valve can be used for ultra-high pressure applications, including in liquid chromatography and other analytical instrument systems.
F16K 3/08 - Gate valves or sliding valves, i.e. cut-off apparatus with closing members having a sliding movement along the seat for opening and closing with flat sealing faces; Packings therefor with pivoted closure members in the form of closure plates arranged between supply and discharge passages with circular closure plates rotatable around their centres
F16K 5/00 - Taps or cocks comprising only cut-off apparatus having at least one of the sealing faces shaped as a more or less complete surface of a solid of revolution, the opening and closing movement being predominantly rotary
F16K 5/08 - Taps or cocks comprising only cut-off apparatus having at least one of the sealing faces shaped as a more or less complete surface of a solid of revolution, the opening and closing movement being predominantly rotary - Details
F16K 5/18 - Special arrangements for separating the sealing faces or for pressing them together for plugs with cylindrical surfaces
55.
Biocompatible tubing for liquid chromatography systems
A biocompatible tube and fitting system that can be used in a liquid chromatography system is described. The tube can have a polymer tip and can be used in conjunction with one or more fitting assembly.
F16L 19/06 - Joints in which sealing surfaces are pressed together by means of a member, e.g. a swivel nut, screwed on, or into, one of the joint parts in which radial clamping is obtained by wedging action on non-deformed pipe ends
F16L 9/147 - Compound tubes, i.e. made of materials not wholly covered by any one of the preceding groups comprising only layers of metal and plastics with or without reinforcement
F16L 9/14 - Compound tubes, i.e. made of materials not wholly covered by any one of the preceding groups
F16L 58/10 - Coatings characterised by the materials used by rubber or plastics
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
F16L 19/04 - Joints in which sealing surfaces are pressed together by means of a member, e.g. a swivel nut, screwed on, or into, one of the joint parts using additional rigid rings, sealing directly on at least one pipe end, which is flared either before or during the making of the connection
56.
Pulse dampener with automatic pressure-compensation
A fluid pulse dampener with automatic pressure-compensation is provided. A system of chambers and channels in the dampener creates an internal feedback mechanism that increases or decreases a compensating pressure on the membrane in response to increases or decreases in the pressure of a fluid moving past the other side of the membrane. Variations of the pulse dampener allow for the input and/or output of gas flow is be restricted or increased as may be desired.
The invention relates to a microfluidic flow cell, which has a storage space (3), which holds liquid reagent material and/or sample material (7) and which is connected to an inlet channel (7) for a fluid (8) that transports the reagent material and/or sample material (7) out of the storage space (3) and to an outlet channel (5) for the reagent material and/or sample material (7) and the fluid (8). According to the invention, the inlet channel (4) and the outlet channel (5) are connected by a bypass (6) that bypasses the storage space (3).
A device which includes a pulse dampener and a degasser or de-bubbler. The device includes a fluid flow path and a fluid chamber located within the device. In addition, the device includes a pulse dampening membrane for dampening pulses in the fluid as it flows through the device. The device also includes a degassing membrane for degassing the fluid as it flows through the device, and/or a de-bubbling membrane for removing gas bubbles from the fluid as it flows through the device. The degassing or de-bubbling membrane can be separate and distinct from the dampening membrane. The de-bubbling membrane can be in addition to or in place of the degassing membrane in some embodiments.
The invention relates to a flow cell having at least one reservoir region (13) containing a liquid reagent (8). According to the invention, the reservoir region (13) is delimited by a carrier element (7) introduced into an opening in the flow cell together with the reagent (8), wherein the carrier element (7) seals off the reservoir region (13) from the outside in a fluid-tight manner, and has a vessel and/or capillary structure (12) holding the liquid reagent (8) on the carrier element (7).
A fluidic connection assembly and methods for quickly connecting or disconnecting a tube to a port by hand and without the use of tools. A body is adapted to receive a tube therethrough, and may have at least two sides which are hinged. Each of the hinged sides has corresponding latching portions or projections located near a lower end of the body. These projections are adapted to fit into a port or other fitting and be securely held in place. The assembly may include a tube extending through a body and through a spring located between the end of the body and the end of the tube, whereby the spring exerts a force directly or indirectly against the end of the tube and against the body, thus holding the tubing securely and sealingly engaged in the port when the assembly is connected. The body may further comprise an additional body or an adapter, and/or a cap and latch. A second spring may be used to push a projecting member into a groove or notch of an adapter when an end of the adapter is inserted into one end of the latch or the body. The fluidic connection assembly is useful in analytical instrument systems, such as for in vitro applications and/or in high pressure applications, among other things, and may be used in methods for connecting, or disconnecting, tubing or a fluidic connection assembly from a port or other fitting or connection.
F16L 37/098 - Couplings of the quick-acting type in which the connection between abutting or axially-overlapping ends is maintained by locking members combined with automatic locking by means of flexible hooks
F16L 37/04 - Couplings of the quick-acting type in which the connection is maintained only by friction of the parts being joined with an elastic outer part pressing against an inner part by reason of its elasticity
F16L 37/084 - Couplings of the quick-acting type in which the connection between abutting or axially-overlapping ends is maintained by locking members combined with automatic locking
F16L 37/133 - Couplings of the quick-acting type in which the connection between abutting or axially-overlapping ends is maintained by locking members using hooks, pawls, or other movable or insertable locking members using flexible hooks
Microfluidic devises and process for making the devices include coating a substrate with an active oxygen layer and covalently bonding a polymeric microfluidic pattern to the substrate and devices made by the process.
A fluidic connection assembly and methods for quickly connecting or disconnecting a tube to a port by hand and without the use of tools. A body is adapted to receive a tube therethrough, and may have at least two sides which are hinged. Each of the hinged sides has corresponding latching portions or projections located near a lower end of the body. These projections are adapted to fit into a port or other fitting and be securely held in place. The assembly may include a tube extending through a body and through a spring located between the end of the body and the end of the tube, whereby the spring exerts a force directly or indirectly against the end of the tube and against the body, thus holding the tubing securely and sealingly engaged in the port when the assembly is connected. The body may further comprise an additional body or an adapter, and/or a cap and latch. A second spring may be used to push a projecting member into a groove or notch of an adapter when an end of the adapter is inserted into one end of the latch or the body. The fluidic connection assembly is useful in analytical instrument systems, such as for in vitro applications and/or in high pressure applications, among other things, and may be used in methods for connecting, or disconnecting, tubing or a fluidic connection assembly from a port or other fitting or connection.
F16L 33/22 - Arrangements for connecting hoses to rigid members; Rigid hose-connectors, i.e. single members engaging both hoses with means not mentioned in the preceding groups for gripping the hose between inner and outer parts
F16L 19/02 - Pipe ends provided with collars or flanges, integral with the pipe or not, pressed together by a screwed member
F16L 37/098 - Couplings of the quick-acting type in which the connection between abutting or axially-overlapping ends is maintained by locking members combined with automatic locking by means of flexible hooks
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
F16L 33/32 - Arrangements for connecting hoses to rigid members; Rigid hose-connectors, i.e. single members engaging both hoses comprising parts outside the hoses only
A manifold assembly has a manifold and can be located between a block and a plate, and serve as a stator for a valve or other component. The manifold, block or plate can have a plurality of ports either integral thereto or removably connected thereto, with the ports adapted to receive and sealingly engage with a tube having an inner tube layer, an outer tube layer, a sleeve, a tip portion, and a nut. Each of the nut, sleeve, inner and outer tubing layers, and tip portion have a passageway therethrough, with at least the passageways in the sleeve, tip portion, outer tube layer, and nut adapted to allow the inner tube layer to pass therethrough or extend over the inner layer. The ends of the tip portion and inner layer together can define a substantially flat surface which can form a seal in a flat-bottomed port of the manifold, block, or plate, which can be used in a component in an analytical instrument system, including for example a liquid chromatography system. The nut, tube, ferrule, and transfer tube or liner tube may comprise biocompatible materials. In addition, the nut may have a slot, such as a slot adapted to allow the tube and the nut to be easily and quickly separated or to allow a portion of the tube to be easily and quickly inserted in the nut.
G01N 1/00 - Sampling; Preparing specimens for investigation
F16L 15/08 - Screw-threaded joints; Forms of screw-threads for such joints with supplementary elements
F16L 19/02 - Pipe ends provided with collars or flanges, integral with the pipe or not, pressed together by a screwed member
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
B01D 15/14 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
B01D 15/16 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
G01N 30/32 - Control of physical parameters of the fluid carrier of pressure or speed
A biocompatible tube and fitting system that can be used in a liquid chromatography system is described. The tube can have a polymer tip and can be used in conjunction with one or more fitting assembly.
F16L 9/14 - Compound tubes, i.e. made of materials not wholly covered by any one of the preceding groups
F16L 58/10 - Coatings characterised by the materials used by rubber or plastics
F16L 9/147 - Compound tubes, i.e. made of materials not wholly covered by any one of the preceding groups comprising only layers of metal and plastics with or without reinforcement
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
F16L 19/04 - Joints in which sealing surfaces are pressed together by means of a member, e.g. a swivel nut, screwed on, or into, one of the joint parts using additional rigid rings, sealing directly on at least one pipe end, which is flared either before or during the making of the connection
A modular sensor for a fluidic analysis or biological assay system, such as an analytical instrument system, and other systems involving fluid flow, includes a cap and base which include one or more sensors therein, which may be a flow sensor, a pressure sensor, a temperature sensor, a pH sensor, and so forth. The base of the modular sensor includes input and output ports for fluid passageways therethrough to provide a fluid pathway which is at least partially adjacent to or near the sensor. The modular sensor may also include an adapter having ports adapted to sealingly engage with fitting assemblies. The sensor may be partially or wholly encapsulated as part of the base of the modular sensor. The modular sensor's base and cap are adapted so that a first modular sensor can be disconnected and removed from a fluidic system and a second modular sensor can be added and connected to the system in place of the first modular sensor. The modular sensor is adapted to be interchangeable with one or more other modular sensors.
A modular sensor for a fluidic analysis or biological assay system, such as an analytical instrument system, and other systems involving fluid flow, includes a cap and base which include one or more sensors therein. The base of the modular sensor includes input and output ports for fluid passageways therethrough to provide a fluid pathway which is at least partially adjacent to or near the sensor. The modular sensor may also include an adapter having ports adapted to sealingly engage with fitting assemblies. The sensor may be partially or wholly encapsulated as part of the base of the modular sensor. The modular sensor's base and cap are adapted so that a first modular sensor can be disconnected and removed from a fluidic system and a second modular sensor can be added and connected to the system in place of the first modular sensor. The modular sensor is adapted to be interchangeable with one or more other modular sensors.
The invention relates to a microfluidic flow cell comprising an electrode (16, 19,...) or sensor device (39) which is located inside the flow cell and from which at least one connecting conductor (15, 18,...) leads to an externally accessible terminal contact. According to the invention, the electrode (16, 19,...) or sensor device (39) is arranged on an insulated substrate member, the connecting conductor (15, 18,...) is embedded in the substrate member, and the substrate member can be inserted into an opening (8) in the flow cell such that the electrode (16, 19,...) or sensor device (39) is placed in the flow cell.
A multi-dimensional liquid analysis system includes a first dimension system and a second dimension system, wherein outflow from the first dimension system is separated at a flow splitter under controlled conditions. The flow splitter separates the first dimension outflow into first and second split outlet flows, with one of the split outlet flows being metered to a designated flow rate with a flow metering device disposed downstream from the flow splitter. The flow metering device selectively closes or opens an outlet flow path to define a volumetric flow rate along that outlet flow path, so that the other split outlet flow is correspondingly controlled.
G01N 30/46 - Flow patterns using more than one column
B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
Presented is a method, apparatus, and computer-readable medium for selectively switching optical paths. The apparatus includes a directing mirror for redirecting light from an incoming path to one of a plurality of input paths and redirecting the light from one of a plurality of output paths to an outgoing path, and a plurality of input mirrors, each one of the plurality of input mirrors operable for redirecting the light from one of the plurality of input paths to one of a plurality of transition paths. The apparatus includes a plurality of light modifying elements, each one of the light modifying elements in a corresponding transition path and a plurality of output mirrors, each one of the plurality of output mirrors operable for redirecting the light from one of the plurality of transition paths to one of a plurality of output paths.
G02B 26/08 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
G02B 21/16 - Microscopes adapted for ultraviolet illumination
09 - Scientific and electric apparatus and instruments
Goods & Services
Chromatography apparatus for laboratory use; chromatography
columns for laboratory use; chromatography columns for use
in purification in the laboratory; scientific and technical
apparatus, namely, optical mirrors; scientific apparatus and
instruments, namely, chromatography columns for use in
purification in the laboratory and parts and fittings
therefor; scientific apparatus and instruments, namely,
fluid handling device used for disposable bioprocessing
applications and parts and fittings therefor; scientific
apparatus and instruments, namely, ultra-high vacuum
chambers; scientific apparatus, namely, sensing and
signaling devices for measurement and quality control of
materials processing by laser; scientific apparatus, namely,
spectrometers and parts and fittings therefor; apparatus for
automatic chromatography for laboratory use; fiber optic
connectors; gas chromatography apparatus for laboratory use;
laboratory apparatus and chromatography systems for use in
protein purification; laboratory filters; liquid
chromatography apparatus for laboratory use; pharmaceutical
and scientific research equipment for use in mass
spectrometers; plug connectors; scientific apparatus and
instruments, namely, chromatography columns for use in
purification in the laboratory and parts and fittings
therefor.
A membrane gas-liquid contactor is arranged to define a fluid flow path for contact with a membrane in a manner to improve degassing efficiency. A degassing module housing the membrane is arranged with flow fields for distributing the fluid flow throughout the membrane contact area. The distributed fluid flow may have a uniform membrane contact opportunity.
A membrane gas-liquid contactor is arranged to define a fluid flow path for contact with a membrane in a manner to improve degassing efficiency. A degassing module housing the membrane is arranged with flow fields for distributing the fluid flow throughout the membrane contact area. The distributed fluid flow may have a uniform membrane contact opportunity.
B01D 15/16 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
A torque limited fitting is provided having a head and a body, which in certain embodiments may be assembled by an operator. The body of the torque limited fitting has a passageway therethrough for receiving and removably holding tubing. The torque limited fitting may be adapted for use with a flat bottom port, such as in an analytical instrument, like liquid chromatography, gas chromatography, ion chromatography, or in in vitro diagnostic systems.
G01N 30/88 - Integrated analysis systems specially adapted therefor, not covered by a single one of groups
F16L 37/244 - Couplings of the quick-acting type in which the connection is made by inserting one member axially into the other and rotating it to a limited extent, e.g. with bayonet-action the coupling being co-axial with the pipe
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
F16L 19/065 - Joints in which sealing surfaces are pressed together by means of a member, e.g. a swivel nut, screwed on, or into, one of the joint parts in which radial clamping is obtained by wedging action on non-deformed pipe ends the wedging action being effected by means of a ring
F16L 15/08 - Screw-threaded joints; Forms of screw-threads for such joints with supplementary elements
F16L 19/02 - Pipe ends provided with collars or flanges, integral with the pipe or not, pressed together by a screwed member
09 - Scientific and electric apparatus and instruments
Goods & Services
Chromatography apparatus for laboratory use; Chromatography columns for laboratory use; Chromatography columns for use in purification in the laboratory; Scientific and technical apparatus, namely, optical mirrors; Scientific apparatus and instruments, namely, chromatography columns for use in purification in the laboratory and parts and fittings therefor; Scientific apparatus and instruments, namely, fluid handling device used for disposable bioprocessing applications and parts and fittings therefor; Scientific apparatus and instruments, namely, ultra-high vacuum chambers; Scientific apparatus, namely, sensing and signaling devices for measurement and quality control of materials processing by laser; Scientific apparatus, namely, spectrometers and parts and fittings therefor; Apparatus for automatic chromatography for laboratory use; Fiber optic connectors; Gas chromatography apparatus for laboratory use; Laboratory apparatus and chromatography systems for use in protein purification; Laboratory filters; Liquid chromatography apparatus for laboratory use; Pharmaceutical and scientific research equipment for use in mass spectrometers; Plug connectors
The invention relates to a sample carrier (7) comprising a region (9) for receiving a sample (18) which is to be analysed, the volume thereof being between 1 - 100 μΙ, and comprising an area (10) for handling the sample carrier. According to the invention, said sample carrier is characterized by devices for the fluid-tight placement of the sample carrier (7) together with the sample (18) in an analysis device. The invention also relates to an analysis device, in particular a flow cell, comprising said type of sample carrier.
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
A61J 1/05 - Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids
76.
Laser systems and optical devices for manipulating laser beams
Various embodiments of a multi-laser system are disclosed. In some embodiments, the multi-laser system includes a plurality of lasers, a plurality of laser beams, a beam positioning system, a thermally stable enclosure, and a temperature controller. The thermally stable enclosure is substantially made of a material with high thermal conductivity such as at least 5 W/(m K). The thermally stable enclosure can help maintain alignment of the laser beams to a target object over a range of ambient temperatures. Various embodiments of an optical system for directing light for optical measurements such laser-induced fluorescence and spectroscopic analysis are disclosed. In some embodiments, the optical system includes a thermally conductive housing and a thermoelectric controller, a plurality of optical fibers, and one or more optical elements to direct light emitted by the optical fibers to illuminate a flow cell. The housing is configured to attach to a flow cell.
G02B 26/08 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the direction of light
H01S 3/23 - Arrangement of two or more lasers not provided for in groups , e.g. tandem arrangement of separate active media
A composite membrane for separations includes a substrate sheet with a non-woven array of nanotubes, and a dopant incorporated with the substrate sheet to form a non-porous, permeable composite. The composite membrane may be used to separate a target gas from a liquid by mounting the composite membrane in a housing chamber, and conditioning a permeate side of the chamber to establish a driving force for the target gas across the non-porous, permeable composite membrane.
B01D 53/22 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
A manifold assembly has a manifold and can be located between a block and a plate, and serve as a stator for a valve or other component. The manifold, block or plate can have a plurality of ports either integral thereto or removably connected thereto, with the ports adapted to receive and sealingly engage with a tube having an inner tube layer, an outer tube layer, a sleeve, a tip portion, and a nut. Each of the nut, sleeve, inner and outer tubing layers, and tip portion have a passageway therethrough, with at least the passageways in the sleeve, tip portion, outer tube layer, and nut adapted to allow the inner tube layer to pass therethrough or extend over the inner layer. The ends of the tip portion and inner layer together can define a substantially flat surface which can form a seal in a flat-bottomed port of the manifold, block, or plate, which can be used in a component in an analytical instrument system, including for example a liquid chromatography system. The nut, tube, ferrule, and transfer tube or liner tube may comprise biocompatible materials. In addition, the nut may have a slot, such as a slot adapted to allow the tube and the nut to be easily and quickly separated or to allow a portion of the tube to be easily and quickly inserted in the nut.
A61B 10/00 - Other methods or instruments for diagnosis, e.g. for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
F16L 15/08 - Screw-threaded joints; Forms of screw-threads for such joints with supplementary elements
F16L 19/02 - Pipe ends provided with collars or flanges, integral with the pipe or not, pressed together by a screwed member
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
B01D 15/14 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
B01D 15/16 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
A device which includes a pulse dampener and a degasser or de-bubbler. The device includes a fluid flow path and a fluid chamber located within the device. In addition, the device includes a pulse dampening membrane for dampening pulses in the fluid as it flows through the device. The device also includes a degassing membrane for degassing the fluid as it flows through the device, and/or a de-bubbling membrane for removing gas bubbles from the fluid as it flows through the device. The degassing or de-bubbling membrane can be separate and distinct from the dampening membrane. The de-bubbling membrane can be in addition to or in place of the degassing membrane in some embodiments.
A device which includes a pulse dampener and a degasser or de-bubbler. The device includes a fluid flow path and a fluid chamber located within the device. In addition, the device includes a pulse dampening membrane for dampening pulses in the fluid as it flows through the device. The device also includes a degassing membrane for degassing the fluid as it flows through the device, and/or a de-bubbling membrane for removing gas bubbles from the fluid as it flows through the device. The degassing or de-bubbling membrane can be separate and distinct from the dampening membrane. The de-bubbling membrane can be in addition to or in place of the degassing membrane in some embodiments.
A fluid pulse dampener with automatic pressure-compensation is provided. A system of chambers and channels in the dampener creates an internal feedback mechanism that increases or decreases a compensating pressure on the membrane in response to increases or decreases in the pressure of a fluid moving past the other side of the membrane. Variations of the pulse dampener allow for the input and/or output of gas flow to be restricted or increased as may be desired.
A fluid pulse dampener with automatic pressure-compensation is provided. A system of chambers and channels in the dampener creates an internal feedback mechanism that increases or decreases a compensating pressure on the membrane in response to increases or decreases in the pressure of a fluid moving past the other side of the membrane. Variations of the pulse dampener allow for the input and / or output of gas flow to be restricted or increased as may be desired.
A composite membrane for separations includes a fabric with a non-woven array of intermingled carbon nanotubes, and a dopant incorporated with the fabric to form a non-porous, permeable composite. The composite membrane may be used to separate a target gas from a liquid by mounting the composite membrane in a housing chamber, and conditioning a permeate side of the chamber to establish a driving force for the target gas across the non-porous, permeable composite membrane.
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
B01D 53/22 - Separation of gases or vapours; Recovering vapours of volatile solvents from gases; Chemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
B82B 3/00 - Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
B82B 1/00 - Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
84.
Optical thin-film notch filter with very wide pass band regions
The present disclosure relates to thin film notch filters having the basic structure of an interference filter. In some embodiments, the filters according to the present disclosure exhibit at least one notch correlating to a pass band defect. The filters of the present disclosure may exhibit at least one of improved pass band bandwidth, improved edge steepness, narrower notch band FWHM, and lower sensitivity to material mismatch, relative to prior known thin film notch filters based on the basic structure of an interference filter. The present disclosure also relates to methods of making the filters described herein, and the use of these filters in optimal measurement systems.
A rotary shear valve having a rotor device and a stator device both with planar faces. The stator face includes a central port located at a common rotational axis, a second port radially spaced a radius R1 from the central port, and a third port spaced at radius R2. The second and third ports are in general linear alignment with the central port. The rotor face includes a first rotor groove extending radially outward from the common rotational axis to a position at radius R2 from the central port. The rotor device is rotatably mounted to the stator device for rotation thereof about the axis, providing fluid-tight, selective relative rotation therebetween between two or more discrete rotor positions. When in a discrete first rotor position, the first rotor groove is oriented in radial alignment with, and fluidly connects, the central port and the second port with the third port.
F16K 11/074 - Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves; Arrangement of valves and flow lines specially adapted for mixing fluid with all movable sealing faces moving as one unit comprising only sliding valves with pivoted closure members with flat sealing faces
An elongated fluid degassing apparatus may be employed as a fluid transfer line for fluidly connecting components in a liquid system, while at the same time degassing, or preventing re-gassing of, the fluid. The fluid transfer line degassing apparatus forms a shell and tube degassing arrangement, wherein shell-side fluid flow is facilitated by one or more spacer elements that centrally position a semi-permeable separation membrane in the shell chamber. The degasser may include one or more tubular separation membranes that provide a gas-permeable, liquid-impermeable contact surface to effect the gas-liquid separation of the process fluid.
A tubing or fitting assembly has an inner tube layer, an outer tube layer, a sleeve, a tip portion, and can have a nut. Each of the nut, sleeve, inner and outer tubing layers, and tip portion have a passageway therethrough, with at least the passageways in the sleeve, tip portion, outer tube layer, and nut adapted to allow the inner tube layer to pass therethrough or extend over the inner layer. The tip portion can be molded over an end portion of the inner tube layer and also over a portion of the sleeve. The sleeve may include a retention feature in the form of a lip which extends into the tip portion, and also a narrower portion so that the tip portion and sleeve remain coupled together. The inner and outer tubing layers can also be retained by an interference fit. The ends of the tip portion and inner layer together define a substantially flat surface which can form a seal in a flat-bottomed port of a component such as may be found in any one of a number of components in an analytical instrument system, including for example a liquid chromatography system. The nut, tube, ferrule, and transfer tube or liner tube may comprise biocompatible materials. In addition, the nut may have a slot, such as a slot adapted to allow the tube and the nut to be easily and quickly separated or to allow a portion of the tube to be easily and quickly inserted in the nut.
An elongated fluid degassing apparatus may be employed as a fluid transfer line for fluidly connecting components in a liquid system, while at the same time degassing, or preventing re-gassing of, the fluid. The fluid transfer line degassing apparatus forms a shell and tube degassing arrangement, wherein shell-side fluid flow is facilitated by one or more spacer elements that centrally position a semi-permeable separation membrane in the shell chamber. The degasser may include one or more tubular separation membranes that provide a gas-permeable, liquid-impermeable contact surface to effect the gas-liquid separation of the process fluid.
A tubing or fitting assembly has an inner tube layer, an outer tube layer, a sleeve, a tip portion, and can have a nut. Each of the nut, sleeve, inner and outer tubing layers, and tip portion have a passageway therethrough, with at least the passageways in the sleeve, tip portion, outer tube layer, and nut adapted to allow the inner tube layer to pass therethrough or extend over the inner layer. The tip portion can be molded over an end portion of the inner tube layer and also over a portion of the sleeve. The ends of the tip portion and inner layer together define a substantially flat surface which can form a seal in a flat-bottomed port of a component such as may be found in any one of a number of components in an analytical instrument system, including for example a liquid chromatography system.
Optical filters and methods of making optical filters are provided. The optical filter can include a first and second stack of layers. The first stack of layers can be configured to provide a cut-on edge for s-polarized radiation incident at a second wavelength value and a cut-off edge for s-polarized radiation incident at a third wavelength value. The second stack of layers can be configured to provide a cut-off edge for s-polarized radiation incident on the second stack of layers at a fourth wavelength value. Further, the fourth wavelength value can lie between the second wavelength value and the third wavelength value. Furthermore, a curve or line of full-width half-maximum (FWHM) values of the optical filter pass-band can define a first derivative with respect to angle-of-incidence values at at least one angle-of-incidence value that is substantially positive or substantially zero.
A springless rotary shear that produces compression forces by utilizing the stiffness properties of polymer seals. The valve is designed to produce an effective spring load, with inherent sealing force, by deflecting polymer elements whose response depends on stiffness that is governed by each component's elastic modulus and geometry. A stator seal protrudes thousandths of an inch beyond a stator seal housing. When a stator is fastened down to the stator seal housing the clamping forces are transmitted to the stator seal, rotor seal, shaft adapter, bearings and housings, and the assembly is deflected to a flush position, resulting in a sealing force between the rotor and stator seal. The transmitted sealing force is as a function of the stiffness of each component and the protrusion distance of the stator seal above the mating surface prior to fastening the stator.
F16K 11/074 - Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves; Arrangement of valves and flow lines specially adapted for mixing fluid with all movable sealing faces moving as one unit comprising only sliding valves with pivoted closure members with flat sealing faces
A springless rotary shear that produces compression forces by utilizing the stiffness properties of polymer seals. The valve is designed to produce an effective spring load, with inherent sealing force, by deflecting polymer elements whose response depends on stiffness that is governed by each component's elastic modulus and geometry. A stator seal protrudes thousandths of an inch beyond a stator seal housing. When a stator is fastened down to the stator seal housing the clamping forces are transmitted to the stator seal, rotor seal, shaft adapter, bearings and housings, and the assembly is deflected to a flush position, resulting in a sealing force between the rotor and stator seal. The transmitted sealing force is as a function of the stiffness of each component and the protrusion distance of the stator seal above the mating surface prior to fastening the stator.
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
F16K 99/00 - Subject matter not provided for in other groups of this subclass
F16K 11/074 - Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves; Arrangement of valves and flow lines specially adapted for mixing fluid with all movable sealing faces moving as one unit comprising only sliding valves with pivoted closure members with flat sealing faces
A multi-path selector valve used in liquid chromatography and other analytical methods for directing fluid along alternate paths of a flowstream. The selector valve has a stator and a rotor. The dynamic face of the stator has a plurality of openings arranged along an inner ring, a plurality of openings arranged along an outer ring, and an annular collection groove formed in the dynamic face. The inner ring, outer ring, and annular collection groove are concentric circles. The rotor's dynamic face is configured to mate with the rear face of the stator, and has two fluid flow paths. One fluid flow path has one end at a rotational center of the rotor and another end of the fluid flow path is configured to be aligned with a stator opening along the inner ring. The second fluid flow path has one end that is configured to be aligned with the annular collection groove and another end that is configured to be aligned with a stator opening along the outer ring.
F16K 11/074 - Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves; Arrangement of valves and flow lines specially adapted for mixing fluid with all movable sealing faces moving as one unit comprising only sliding valves with pivoted closure members with flat sealing faces
The present disclosure relates to thin film optical interference filters. The filters include a substrate and a plurality of alternating material layers deposited on the substrate. When operated at about 45° angle of incidence, the filters exhibit at least one of improved polarization splitting, edge steepness, bandpass bandwidth, and blocking, relative to conventional thin film interference filters.
The invention relates to a flow cell, in particular for analyzing or/and synthesizing substances, comprising at least one storage zone (10; 19; 33) connected to a duct (7-9; 20) for conducting fluid out of, into or/and through the storage zone; the duct includes a duct section (14) which is delimited by a substrate (1) and a film (3) joined to the substrate and in which the duct is sealed and can be opened at a predetermined breaking point by deflecting the film. The flow cell of the invention is characterized in that the film covers a recess (15) in the substrate which forms the duct section; a sealing wall (16) that seals the duct and is integrally joined to the substrate is placed in said recess (15); furthermore, the predetermined breaking point is formed by a breakable joining region between the film and an edge portion (17) of the sealing wall facing the film; and finally, the dimensions of a peripheral area of the sealing wall which is formed in the edge portion and runs parallel to the film determine the surface area of the joining region.
The invention relates to a reagent reservoir for fluids as part of a microfluidic flow cell or as a separate module, comprising a storage chamber (8) connected to a duct (10) for conducting fluid out of, into or/and through the storage chamber (8); the duct (10) includes a duct section which is delimited by a substrate (1) and a film (6) joined to the substrate (1) and in which the duct (10) is sealed and can be opened at a predetermined breaking point by deflecting the film (6); the film (6) joined to the substrate (1) also delimits the storage chamber (8) in addition to the duct section. The reagent reservoir of the invention is characterized in that the film (6) covers a recess in the substrate (1) which forms the duct section; a sealing wall (11) that seals the duct (10) and is integrally joined to the substrate (1) is placed in said recess (15); furthermore, the predetermined breaking point is formed by a breakable joining region between the film and an edge portion of the sealing wall (11) facing the film (6); and finally, the dimensions of a peripheral area of the sealing wall which is formed in the edge portion and runs parallel to the film determine the surface area of the joining region.
Frits for use in analytical instrument systems, including liquid chromatography systems, particularly HPLC and UHPLC systems, and methods of making and using the frits, are provided. The frits can have multiple layers, which may have different surface finishes on different surfaces.
B01D 15/12 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the preparation of the feed
B01D 29/56 - Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups ; Filtering elements therefor with multiple filtering elements, characterised by their mutual disposition in series connection
Frits for use in analytical instrument systems, including liquid chromatography systems, particularly HPLC and UHPLC systems, and methods of making and using the frits, are provided. The frits can have multiple layers, which may have different surface finishes on different surfaces. The present disclosure overcomes one or more of the deficiencies of the prior art by providing fits that are well-suited for use in liquid chromatography systems, and are particularly well-suited for use in high pressure and ultra-high pressure liquid chromatography systems, such as HPLC and UHPLC.
Fluidic connection assemblies, ports, unions and other components are provided that are well-suited for use in HPLC and UHPLC, as well as in other analytical instrument systems. Such assemblies, ports, unions and components can be biocompatible. The present disclosure overcomes one or more of the deficiencies of the prior art by providing fluidic connection assemblies that are well-suited for use in Al and LC systems, and are particularly well-suited in some embodiments for use in high pressure and ultra-high pressure liquid chromatography systems, such as HPLC and UHPLC.
F16L 19/06 - Joints in which sealing surfaces are pressed together by means of a member, e.g. a swivel nut, screwed on, or into, one of the joint parts in which radial clamping is obtained by wedging action on non-deformed pipe ends
