Abstract

The present disclosure relates to antigen multimers capable of detecting antigen-specific chimeric antigen receptor (CAR) T cells. In particular, it relates to antigen multimers comprising a first multimerization domain and a plurality of antigens. The disclosure further provides compositions comprising the multimers, and various methods for their use.

IPC Classes  ?

• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• C07K 14/725 - T-cell receptors
• G01N 33/566 - ImmunoassayBiospecific binding assayMaterials therefor using specific carrier or receptor proteins as ligand binding reagent
• C07K 14/705 - ReceptorsCell surface antigensCell surface determinants

Goods & Services

Chemical products for diagnostic (non-medical), industrial and scientific purposes; diagnostic reagents for diagnostic (not for medical or veterinary) and scientific purposes; research reagents for scientific and diagnostic purposes; diagnostic test materials for scientific and diagnostic purposes (not for medical or veterinary purposes); diagnostic kits for scientific and diagnostic purposes (not for medical or veterinary purposes); test kits for research and diagnostic purposes (not for medical or veterinary purposes); biochemical reagents (not for medical or veterinary purposes); analytical preparations for scientific purposes related to vaccines and immunotherapeutics, cancer vaccines, borrelia vaccines, tuberculosis vaccines, HIV vaccines, CMV vaccines and other vaccines, or for use in connection with therapy and immunotherapy, including cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissues, and for analysis of infectious diseases and autoimmunity, and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; chemical reagents, other than for medical or veterinary purposes. Preparations for pharmaceutical purposes, preparations for medical purposes, chemical-pharmaceutical preparations, diagnostic preparations for medical purposes, reagents for medical and veterinary purposes; vaccines; analytical preparations for medical purposes, including for each of the above preparations for the development or analysis of vaccines, immunotherapeutics and cellular therapy, including cancer vaccines and immunotherapeutics, borrelia vaccines, tuberculosis vaccines, HIV vaccines and CMV vaccines, T-cell treatments, or for use in connection with cancer therapy or other therapy, for the analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissues, and infectious diseases, and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring.

Abstract

Disclosed herein is a panel comprising one or more MHC multimers; and a panel comprising one or more pools of MHC multimers, wherein each pool comprises one or more MHC multimers; wherein said MHC multimers comprise an antigenic peptide P derived from a Borrelia antigenic polypeptide selected from the group consisting of OppA, DbpA, FlhF, FlaB and P37-42; as well as uses thereof in the detection of Borrelia-specific T cells and the diagnosis, treatment and monitoring of Borrelia disease in an individual.

IPC Classes  ?

• C07K 14/20 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/02 - Bacterial antigens
• A61K 49/14 - Peptides, e.g. proteins
• A61P 31/04 - Antibacterial agents
• C07K 14/74 - Major histocompatibility complex [MHC]
• G01N 15/01 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
• G01N 15/10 - Investigating individual particles
• G01N 15/1434 - Optical arrangements
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Goods & Services

Chemical products for diagnostic, industrial and scientific purposes, namely reagents and assays for activation, stimulation and proliferation of immune cells T cells and B cells, other than for medical or veterinary use; Diagnostic reagents for diagnostic and scientific purposes, other than for medical or veterinary use; Research reagents for scientific and diagnostic purposes, other than for medical or veterinary use; Diagnostic test materials in the nature of reagents and assays for scientific and diagnostic purposes, other than for medical or veterinary use; Diagnostic kits comprising diagnostic agents, preparations and substances for scientific and diagnostic purposes, other than for medical or veterinary use; Assays for research and diagnostic purposes, other than for medical or veterinary use; Biochemical reagents, other than for medical or veterinary use; Analytical preparations in the nature of reagents and assays for scientific purposes related to research and development of vaccines and immunotherapeutics, cancer vaccines, borrelia vaccines, tuberculosis vaccines, HIV vaccines, CMV vaccines and other vaccines, or for use in connection with research and development of drug therapy and immunotherapy, including cancer therapy, cancer immunotherapy, for scientific analysis of pharmaceuticals for T-cell lymphoma, T-cell infiltration of solid tumors and tissues, and for analysis of pharmaceuticals infectious diseases and autoimmunity, and for scientific and research use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring, other than for medical or veterinary use; Chemical reagents for diagnostic, industrial and scientific purposes Preparations for pharmaceutical purposes, for the treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; Preparations for medical purposes, namely, diagnostic preparations for medical purposes and medical preparations for treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; Chemical-pharmaceutical preparations for the treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; Diagnostic preparations for medical purposes; Reagents for medical and veterinary purposes; Vaccines; Analytical preparations in the nature of assays and reagents for medical purposes, including for the medical or diagnostic analysis of vaccines, immunotherapeutics and cellular therapy, including cancer vaccines and immunotherapeutics, borrelia vaccines, tuberculosis vaccines, HIV vaccines and CMV vaccines, T-cell treatments, or for use in connection with cancer therapy or other therapy, for the diagnosis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissues, and infectious diseases, and for use in connection with medical or diagnostic analysis of toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring

Goods & Services

(1) Chemical products for diagnostic (non-medical), industrial and scientific purposes; diagnostic reagents for diagnostic (not for medical or veterinary) and scientific purposes; research reagents for scientific and diagnostic purposes; diagnostic test materials for scientific and diagnostic purposes (not for medical or veterinary purposes); diagnostic kits for scientific and diagnostic purposes (not for medical or veterinary purposes); test kits for research and diagnostic purposes (not for medical or veterinary purposes); biochemical reagents (not for medical or veterinary purposes); analytical preparations for scientific purposes related to vaccines and immunotherapeutics, cancer vaccines, borrelia vaccines, tuberculosis vaccines, HIV vaccines, CMV vaccines and other vaccines, or for use in connection with therapy and immunotherapy, including cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissues, and for analysis of infectious diseases and autoimmunity, and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; chemical reagents, other than for medical or veterinary purposes. (2) Preparations for pharmaceutical purposes, preparations for medical purposes, chemical-pharmaceutical preparations, diagnostic preparations for medical purposes, reagents for medical and veterinary purposes; vaccines; analytical preparations for medical purposes, including for each of the above preparations for the development or analysis of vaccines, immunotherapeutics and cellular therapy, including cancer vaccines and immunotherapeutics, borrelia vaccines, tuberculosis vaccines, HIV vaccines and CMV vaccines, T-cell treatments, or for use in connection with cancer therapy or other therapy, for the analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissues, and infectious diseases, and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring.

Abstract

The present disclosure relates peptide pools and MHC class I/peptide multimers comprising peptides from said peptide pools. These pools and multimers are useful as MHC class I allele-matched negative control reagents for identifying peptide-unspecific binding of immune cells, such as T cells. The disclosure further provides compositions, nucleic acids and vectors comprising or encoding said pools or multimers, and methods for their use or production.

IPC Classes  ?

• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
• C07K 14/74 - Major histocompatibility complex [MHC]
• C40B 40/10 - Libraries containing peptides or polypeptides, or derivatives thereof

Abstract

The present disclosure relates to multimers capable of efficiently activating immune cells, such as T cells. In particular, it relates to multimers comprising at least two different ligands, such as a MHC-peptide and an anti-CD28 antibody, capable of binding to and together activate said immune cell. The disclosure further provides nucleic acid, vectors, and compositions encoding or comprising said multimers, and various methods for their use.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61K 40/11 - T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cellsLymphokine-activated killer [LAK] cells
• A61K 40/31 - Chimeric antigen receptors [CAR]
• A61K 40/42 - Cancer antigens
• A61K 47/00 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient
• C07H 1/00 - Processes for the preparation of sugar derivatives
• C07K 14/74 - Major histocompatibility complex [MHC]
• C09J 105/02 - DextranDerivatives thereof
• C12N 5/00 - Undifferentiated human, animal or plant cells, e.g. cell linesTissuesCultivation or maintenance thereofCulture media therefor
• C12P 19/08 - Dextran

IPC Classes  ?

• A61K 40/11 - T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cellsLymphokine-activated killer [LAK] cells
• A61K 40/31 - Chimeric antigen receptors [CAR]
• A61K 40/42 - Cancer antigens
• C07K 14/74 - Major histocompatibility complex [MHC]
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C09J 105/02 - DextranDerivatives thereof
• C12P 19/08 - Dextran

IPC Classes  ?

• C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans

Abstract

The present disclosure relates to MHC class I molecules, such as HLA-E, and peptide- MHC class I complexes with improved stability and/or refolding yield due to one or more introduced disulphide bridges. The disclosure further provides MHC class I multimers, cells, such as stem cells, comprising said MHC class I molecules, and various methods for their use.

IPC Classes  ?

• C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans

Abstract

The present invention relates to detection molecules comprising at least one binding molecule, at least one linker and at least one label, and detection methods making use of same. The invention provides a high-throughput method for detection, isolation and/or identification of specific entities or cells.

IPC Classes  ?

• G01N 33/532 - Production of labelled immunochemicals
• G01N 33/533 - Production of labelled immunochemicals with fluorescent label
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

The present invention relates to detection molecules comprising at least one binding molecule, at least one linker and at least one label, and detection methods making use of same. The invention provides a high-throughput method for detection, isolation and/or identification of specific entities or cells.

IPC Classes  ?

• G01N 33/532 - Production of labelled immunochemicals
• G01N 33/533 - Production of labelled immunochemicals with fluorescent label
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Goods & Services

Scientific and technological services; scientific research; diagnostic services related to research; industrial analysis and research services; basic research and clinical research, hereunder for medicine and vaccine development; research and development in the field of diagnostic preparations; scientific analysis services; scientific laboratory services; quality control testing and consultancy related thereto; scientific research, testing and analysis services; providing scientific technology and methods to others; providing scientific information about industrial analysis and research services; development of scientific, chemical and medical products for others for medical and research purposes; development of scientific, chemical and medical products for others in the fields of biochemistry and biotechnology; providing scientific information, advice and consultancy to others in the fields of biochemistry and biotechnology.

Abstract

The present invention relates to detection molecules comprising at least one binding molecule, at least one linker and at least one label, and detection methods making use of same. The invention provides a high-throughput method for detection, isolation and/or identification of specific entities or cells.

IPC Classes  ?

• G01N 33/532 - Production of labelled immunochemicals
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• G01N 33/533 - Production of labelled immunochemicals with fluorescent label

Abstract

Disclosed herein include systems, methods, compositions, and kits suitable for the use of dextramers in single cell analysis. In some embodiments, one or more primers allowing generation of separate libraries for proteins (e.g., antibodies) and for dextramers are used.

IPC Classes  ?

• C12Q 1/6804 - Nucleic acid analysis using immunogens
• C12Q 1/6806 - Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
• C12Q 1/6869 - Methods for sequencing
• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing

Abstract

Disclosed herein include systems, methods, compositions, and kits suitable for the use of dextramers in single cell analysis. In some embodiments, one or more primers allowing generation of separate libraries for proteins (e.g., antibodies) and for dextramers are used.

IPC Classes  ?

• C12Q 1/6874 - Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation [SBH]
• C12Q 1/6804 - Nucleic acid analysis using immunogens

Goods & Services

Scientific and technological services, namely, scientific research, analysis and testing in the fields of medicine, pharmaceuticals, the immune system, medical diagnostic analysis and vaccines; scientific research; scientific research services, namely, diagnostic services related to research; analysis of medicine, pharmaceuticals and vaccines of others to assure compliance with industry standards; industrial research services in the fields of medicine, pharmaceuticals, the immune system, medical diagnostic analysis and vaccines; basic scientific research and clinical scientific research, hereunder for medicine and vaccine development; product research and development in the field of diagnostic preparations; scientific analysis services in fields of medicine, pharmaceuticals, the immune system, medical diagnostic analysis and vaccines; scientific laboratory services; quality control testing and consultancy related thereto; scientific research, testing and analysis services in the fields of medicine, pharmaceuticals, the immune system, medical diagnostic analysis and vaccines; providing scientific technology and methods to others, namely, rental of laboratory apparatus and instruments and scientific research consulting; providing scientific information about industrial analysis and research services in the fields of medicine, pharmaceuticals, the immune system, medical diagnostic analysis and vaccines; development of scientific, chemical and medical products for others for medical and research purposes; development of scientific, chemical and medical products for others in the fields of biochemistry and biotechnology; providing scientific information, advice and consultancy to others in the fields of biochemistry and biotechnology

Goods & Services

Scientific and technological services; scientific research; diagnostic services related to research; industrial analysis and research services; basic research and clinical research, hereunder for medicine and vaccine development; research and development in the field of diagnostic preparations; scientific analysis services; scientific laboratory services; quality control testing and consultancy related thereto; scientific research, testing and analysis services; providing scientific technology and methods to others; providing scientific information about industrial analysis and research services; providing scientific, chemical and medical products to others for medical and research purposes; providing scientific, chemical and medical products to others in the fields of biochemistry and biotechnology; providing scientific information, advice and consultancy to others in the fields of biochemistry and biotechnology.

Abstract

Borrelia disease in an individual.

IPC Classes  ?

• A61K 47/61 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
• A61K 39/02 - Bacterial antigens
• A61K 49/14 - Peptides, e.g. proteins
• A61P 31/04 - Antibacterial agents
• C07K 14/20 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
• C07K 14/74 - Major histocompatibility complex [MHC]
• G01N 15/1434 - Optical arrangements
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• G01N 15/01 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
• G01N 15/10 - Investigating individual particles

Goods & Services

Chemicals used in diagnostics, industry and science; diagnostic reagents for diagnostic (other than medical and veterinary) and scientific purposes; research reagents for scientific and diagnostic purposes; diagnostic test materials for scientific and diagnostic (other than medical and veterinary) purposes; diagnostic kits for scientific and diagnostic (other than medical and veterinary) purposes; assays for research and diagnostic (other than medical and veterinary) purposes; biochemical reagents (other than medical and veterinary); preparations for analysis for research purposes related to vaccines and immunotherapy, cancer vaccines, Lyme disease vaccines, TB-vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, including cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue; preparations for analysis for research purposes related to analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; chemical reagents for other than medicinal and veterinary purposes. Preparations for pharmaceutical purposes; preparations for medical purposes; chemico-pharmaceutical preparations; diagnostic preparations for medical purposes; reagents for medical and veterinary purposes; vaccines; preparations for analysis for medical purposes, hereunder for each of the abovementioned preparations for development or analysis of vaccines, immunotherapeutics and cellular therapies, including cancer vaccines and immunotherapeutics, Lyme disease vaccines, TB-vaccines, HIV-vaccines and CMV-vaccines, T-cell therapies, or for use in connection with cancer therapy or other therapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for infectious diseases; preparations for analysis for medical purposes, hereunder for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring.

Goods & Services

Chemicals used in diagnostics, industry and science; diagnostic reagents for diagnostic (other than medical and veterinary) and scientific purposes; research reagents for scientific and diagnostic purposes; diagnostic test materials for scientific and diagnostic (other than medical and veterinary) purposes; diagnostic kits for scientific and diagnostic (other than medical and veterinary) purposes; assays for research and diagnostic (other than medical and veterinary) purposes; biochemical reagents (other than medical and veterinary); preparations for analysis for research purposes related to vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB-vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, including cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue; preparations for analysis for research purposes related to analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; chemical reagents for other than medicinal and veterinary purposes. Preparations for pharmaceutical purposes; preparations for medical purposes; chemical-pharmaceutical preparations; diagnostic preparations for medical purposes; reagents for medical and veterinary purposes; vaccines; preparations for analysis for medical purposes, hereunder for each of the abovementioned preparations for development or analysis of vaccines, immunotherapeutics and cellular therapies, including cancer vaccines and immunotherapeutics, borrelia vaccines, TB-vaccines, HIV-vaccines and CMV-vaccines, T-cell therapies, or for use in connection with cancer therapy or other therapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for infectious diseases; preparations for analysis for medical purposes, hereunder for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring. Scientific and technological services; scientific research; diagnostic services related to research; industrial analysis and research services; basic research and clinical research, hereunder for medicine and vaccine development; research and development in the field of diagnostic preparations.

Goods & Services

Chemicals used in industry and science, in the nature of immune related chemicals for immune cell analysis, immune cell monitoring, immune cell detection and immune cell stimulation and immune related chemicals used in science in the nature of MHC monomer and multimer reagents, MR1 monomer and multimer reagents, CD1 monomer and multimer reagents, antibodies, antigen monomer and multimer reagents, reagents, diagnostic agents, control reagents, oligonucleotide conjugated multimer reagents in the nature of DNA/RNA oligo conjugated multimer reagents; diagnostic reagents for diagnostic being research use, other than medical and veterinary use, and scientific use; research diagnostic reagents for scientific use; diagnostic test materials for scientific and diagnostic, other than medical and veterinary, purposes, namely, diagnostic reagents and preparations, except for medical or veterinary use; diagnostic kits for scientific and diagnostic, other than medical and veterinary, purposes comprised of diagnostic reagents and preparations, except for medical or veterinary use and also comprised of immune related chemicals used in science, in the nature of MHC monomer and multimer reagents, MR1 monomer and multimer reagents, CD1 monomer and multimer reagents, antibodies, antigen monomer and multimer reagents, reagents, diagnostic agents, control reagents, oligonucleotide conjugated multimer reagents in the nature of DNA/RNA oligo conjugated multimer reagents; assays for research purposes; biochemical reagents for non- medical purposes, other than medical and veterinary; chemical and diagnostic preparations for analysis for research purposes related to vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB- vaccines, HIV-vaccines, CMV-vaccines and other vaccines, and for use in scientific research in connection with therapy and immunotherapy, in particular, for use in cancer therapy, cancer immunotherapy, for analysis of T-cell lymphoma, T-cell infiltration of solid tumors and tissue; chemical, and diagnostic preparations for analysis for research purposes related to analysis of infectious diseases, autoimmunity and for use in scientific research in connection with toxicological studies, transplantation, immune monitoring, and vaccines and T-cell monitoring; chemical reagents for other than medicinal and veterinary purposes Preparations for pharmaceutical purposes, namely, pharmaceutical preparations for the treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; preparations for medical purposes, namely, diagnostic preparations for medical purposes and medical preparations for treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; chemical-pharmaceutical preparations for treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T- cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; diagnostic preparations for medical purposes; vaccines; diagnostic preparations for analysis for medical purposes, hereunder for each of the abovementioned preparations for medical analysis of vaccines, immunotherapeutics and cellular therapies, in particular cancer vaccines and immunotherapeutics, borrelia vaccines, TB-vaccines, HIV- vaccines and CMV-vaccines, T-cell therapies, and for use in connection with cancer therapy or other therapy, for medical analysis and treatment of T- cell lymphoma, T-cell infiltration of solid tumors and tissue, and for infectious diseases; diagnostic preparations for analysis for medical purposes, hereunder for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring Scientific and technological services, namely, scientific research, analysis and testing in the fields of medicine, pharmaceuticals, the immune system, medical diagnostic analysis and vaccines; scientific research; scientific research services, namely, diagnostic services related to research; analysis of medicine, pharmaceuticals and vaccines of others to assure compliance with industry standards; industrial research services in the fields of medicine, pharmaceuticals, the immune system, medical diagnostic analysis and vaccines; basic scientific research and clinical scientific research, hereunder for medicine and vaccine development; product research and development in the field of diagnostic preparations

Goods & Services

Chemicals used in industry and science, in the nature of immune related chemicals for immune cell analysis, immune cell monitoring, immune cell detection and immune cell stimulation and immune related chemicals used in science in the nature of MHC monomer and multimer reagents, MR1 monomer and multimer reagents, CD1 monomer and multimer reagents, antibodies, antigen monomer and multimer reagents, reagents, diagnostic agents, control reagents, oligonucleotide conjugated multimer reagents in the nature of DNA/RNA oligo conjugated multimer reagents; diagnostic reagents for diagnostic being research use, other than medical and veterinary use, and scientific use; research diagnostic reagents for scientific use; diagnostic test materials for scientific and diagnostic, other than medical and veterinary, purposes, namely, diagnostic reagents and preparations, except for medical or veterinary use; diagnostic kits for scientific and diagnostic, other than medical and veterinary, purposes comprised of diagnostic reagents and preparations, except for medical or veterinary use and also comprised of immune related chemicals used in science, in the nature of MHC monomer and multimer reagents, MR1 monomer and multimer reagents, CD1 monomer and multimer reagents, antibodies, antigen monomer and multimer reagents, reagents, diagnostic agents, control reagents, oligonucleotide conjugated multimer reagents in the nature of DNA/RNA oligo conjugated multimer reagents; assays for research purposes; biochemical reagents for non-medical purposes, other than medical and veterinary; chemical and diagnostic preparations for analysis for research purposes related to vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB-vaccines, HIV-vaccines, CMV-vaccines and other vaccines, and for use in scientific research in connection with therapy and immunotherapy, in particular, for use in cancer therapy, cancer immunotherapy, for analysis of T-cell lymphoma, T-cell infiltration of solid tumors and tissue; chemical, and diagnostic preparations for analysis for research purposes related to analysis of infectious diseases, autoimmunity and for use in scientific research in connection with toxicological studies, transplantation, immune monitoring, and vaccines and T-cell monitoring; chemical reagents for other than medicinal and veterinary purposes Preparations for pharmaceutical purposes, namely, pharmaceutical preparations for the treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; preparations for medical purposes, namely, diagnostic preparations for medical purposes and medical preparations for treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; chemical-pharmaceutical preparations for treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; diagnostic preparations for medical purposes; vaccines; diagnostic preparations for analysis for medical purposes, hereunder for each of the abovementioned preparations for medical analysis of vaccines, immunotherapeutics and cellular therapies, in particular cancer vaccines and immunotherapeutics, borrelia vaccines, TB-vaccines, HIV-vaccines and CMV-vaccines, T-cell therapies, and for use in connection with cancer therapy or other therapy, for medical analysis and treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for infectious diseases; diagnostic preparations for analysis for medical purposes, hereunder for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring

Goods & Services

(1) Chemicals used in medical diagnostics in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; diagnostic preparations for medical-scientific research use; diagnostic reagents for medical-scientific research use; diagnostic reagents for use in medical diagnostics applications in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; research reagents for use in medical diagnostics applications in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; diagnostic reagents for medical-scientific research use in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis and treatment of T-cell lymphoma, T-cell infiltration of solid tumours and tissue, and for analysis of infectious diseases, auto-immunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; biochemical reagents for use in medical diagnostics applications in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; preparations for analysis for research purposes related to vaccines and immunotherapy, cancer vaccines, Lyme disease vaccines, TB-vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring. (2) Preparations for pharmaceutical purposes for treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious disease; preparations for medical purposes for treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; chemico-pharmaceutical preparations for treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; diagnostic preparations for medical purposes for use in the diagnosis and treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases related to immune suppression, autoimmune disease and infectious diseases; reagents for medical and veterinary purposes for use in the diagnosis and treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; human vaccines; chemical preparations for analysis for medical diagnostic purposes in relation to vaccines, immunotherapeutics and cellular therapies, cancer vaccines and immunotherapeutics, Lyme disease vaccines, TB-vaccines, HIV-vaccines and CMV-vaccines, T-cell therapies, and for use in connection with cancer therapy and other therapy, for analysis and treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and infectious diseases; preparations for analysis for medical diagnostic purposes in relation to medical procedures and diagnosis, namely transplantation, immune monitoring, and vaccines and T-cell monitoring; Chemicals used in medical treatment in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for treatment of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; diagnostic reagents for use in medical diagnostics applications in the field of vaccines and immunotherapy, cancer vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue; diagnostic chemical reagents for use in medical diagnostics applications in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis and treatment of T-cell lymphoma, T-cell infiltration of solid tumours and tissue, and for analysis of infectious diseases, auto immunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; diagnostic kits for use in medical diagnostics applications in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; assays for use in medical diagnostics applications in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; chemical reagents for use in medical diagnostics applications in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring.

Goods & Services

Chemicals used in diagnostics, industry and science; diagnostic reagents for diagnostic (other than medical and veterinary) and scientific purposes; research reagents for scientific and diagnostic purposes; diagnostic test materials for scientific and diagnostic (other than medical and veterinary) purposes; diagnostic kits for scientific and diagnostic (other than medical and veterinary) purposes; assays for research and diagnostic (other than medical and veterinary) purposes; biochemical reagents (other than medical and veterinary); preparations for analysis for research purposes related to vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB-vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, including cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue; preparations for analysis for research purposes related to analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; chemical reagents for other than medicinal and veterinary purposes. Preparations for pharmaceutical purposes; preparations for medical purposes; chemical-pharmaceutical preparations; diagnostic preparations for medical purposes; reagents for medical and veterinary purposes; vaccines; preparations for analysis for medical purposes, hereunder for each of the abovementioned preparations for development or analysis of vaccines, immunotherapeutics and cellular therapies, including cancer vaccines and immunotherapeutics, borrelia vaccines, TB-vaccines, HIV-vaccines and CMV-vaccines, T-cell therapies, or for use in connection with cancer therapy or other therapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for infectious diseases; preparations for analysis for medical purposes, hereunder for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring. Scientific and technological services; scientific research; diagnostic services related to research; industrial analysis and research services; basic research and clinical research, hereunder for medicine and vaccine development; research and development in the field of diagnostic preparations.

Goods & Services

(1) Preparations for pharmaceutical purposes for analysis and treatment of immune cell related diseases, cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; pharmaceutical preparations for medical purposes for analysis and treatment of immune cell related diseases, cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; chemical-pharmaceutical preparations for analysis and treatment of immune cell related diseases, cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; diagnostic preparations for medical purposes for use in the diagnosis and treatment of immune cell related diseases, cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; reagents for medical and veterinary purposes for use in the diagnosis and treatment of immune cell related diseases, cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; chemical preparations for development, use and analysis of cancer vaccines, COVID-19 vaccines, borrelia vaccines, TB vaccines, HIV vaccines and CMV vaccines, and for use in connection with immune related therapy, cancer therapy, for analysis or treatment of immune related diseases, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for infectious diseases, and for use in connection with medical analysis, procedures and diagnosis, namely transplantation, immune cell detection, immune cell monitoring, immune cell isolation, immune cell stimulation, immune cell therapy, immune monitoring, and vaccines and T-cell monitoring. (1) Scientific and technological services and research and design services in the field of immune cell detection, immune cell monitoring, immune cell isolation, immune cell stimulation, immune cell therapy, diagnosis involving analysis of immune cells, medicine and vaccine development; industrial analysis and research services in the field of immune cell detection, immune cell monitoring, immune cell isolation, immune cell stimulation, immune cell therapy, diagnosis involving analysis of immune cells, medicine and vaccine development; basic research and clinical research in the field of immune cell detection, immune cell monitoring, immune cell isolation, immune cell stimulation, immune cell therapy, diagnosis involving analysis of immune cells, medicine and vaccine development.

Goods & Services

Chemicals used in diagnostics, industry and science; diagnostic reagents for diagnostic (other than medical and veterinary) and scientific purposes; research reagents for scientific and diagnostic purposes; diagnostic test materials for scientific and diagnostic (other than medical and veterinary) purposes; diagnostic kits for scientific and diagnostic (other than medical and veterinary) purposes; assays for research and diagnostic (other than medical and veterinary) purposes; biochemical reagents (other than medical and veterinary); preparations for analysis for research purposes related to vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB-vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, including cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue; preparations for analysis for research purposes related to analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; chemical reagents for other than medicinal and veterinary purposes. Preparations for pharmaceutical purposes; preparations for medical purposes; chemical-pharmaceutical preparations; diagnostic preparations for medical purposes; reagents for medical and veterinary purposes; vaccines; preparations for analysis for medical purposes, hereunder for each of the abovementioned preparations for development or analysis of vaccines, immunotherapeutics and cellular therapies, including cancer vaccines and immunotherapeutics, borrelia vaccines, TB-vaccines, HIV-vaccines and CMV-vaccines, T-cell therapies, or for use in connection with cancer therapy or other therapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for infectious diseases; preparations for analysis for medical purposes, hereunder for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring.

Goods & Services

Chemicals used in diagnostics, industry and science; diagnostic reagents for diagnostic (other than medical and veterinary) and scientific purposes; research reagents for scientific and diagnostic purposes; diagnostic test materials for scientific and diagnostic (other than medical and veterinary) purposes; diagnostic kits for scientific and diagnostic (other than medical and veterinary) purposes; assays for research and diagnostic (other than medical and veterinary) purposes; biochemical reagents (other than medical and veterinary); preparations for analysis for research purposes related to vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB-vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, including cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue; preparations for analysis for research purposes related to analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; chemical reagents for other than medicinal and veterinary purposes. Preparations for pharmaceutical purposes; preparations for medical purposes; chemical-pharmaceutical preparations; diagnostic preparations for medical purposes; reagents for medical and veterinary purposes; vaccines; preparations for analysis for medical purposes, hereunder for each of the abovementioned preparations for development or analysis of vaccines, immunotherapeutics and cellular therapies, including cancer vaccines and immunotherapeutics, borrelia vaccines, TB-vaccines, HIV-vaccines and CMV-vaccines, T-cell therapies, or for use in connection with cancer therapy or other therapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for infectious diseases; preparations for analysis for medical purposes, hereunder for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring.

Goods & Services

(1) Chemicals used in medical diagnostics and treatment in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; diagnostic preparations for medical scientific research use; diagnostic reagents for medical-scientific research use; diagnostic reagents for use in medical diagnostics applications in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; research reagents for use in medical diagnostics applications in the field of vaccines and Immunotherapy, cancer vaccines, borrelia vaccines, TB vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; diagnostic test materials for use in medical diagnostics applications in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumours and tissue, and for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; diagnostic kits for use in medical diagnostics applications in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TBvaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis and treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; assays for use in medical diagnostics applications in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TBvaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; biochemical reagents for use in medical diagnostics applications in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TBvaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumours and tissue, and for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; preparations for analysis for research purposes related to vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB-vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue; preparations for analysis for research purposes related to analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; chemical reagents for use in medical diagnostics applications in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TBvaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring. (2) Preparations for pharmaceutical purposes for treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; preparations for medical purposes for treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; chemical-pharmaceutical preparations for treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; diagnostic preparations for medical purposes for use in the diagnosis and treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; reagents for medical and veterinary purposes for use in the diagnosis and treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious disease; vaccines; chemical preparations for analysis for medical diagnostic purposes in relation to vaccines, immunotherapeutics and cellular therapies, cancer vaccines and immunotherapeutics, borrelia vaccines, TB vaccines, HIV-vaccines and CMV-vaccines, T-cell therapies, and for use in connection with cancer therapy and other therapy, for analysis and treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, infectious diseases; chemical preparations for analysis for medical diagnostic purposes, in relation to organ transplantation, immune monitoring, and vaccines and T-cell monitoring.

Goods & Services

Chemicals used in diagnostics, industry and science, other than for medical or veterinary purposes; diagnostic and research reagents for scientific and diagnostic purposes other than medical or veterinary diagnostic purposes; diagnostic test materials for scientific and diagnostic purposes other than medical or veterinary diagnostic purposes; diagnostic kits for scientific and diagnostic purposes other than medical or veterinary diagnostic purposes consisting primarily of MHC multimer reagents, monoclonal antibodies, reagents, diagnostic agents, control reagents, DNA/RNA oligo's and DNA/RNA oligo conjugated reagents; assays for research and diagnostic purposes other than medical or veterinary diagnostic purposes; biochemical reagents used for non-medical purposes; chemical preparations for analysis for research purposes related to vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB-vaccines, HIV-vaccines, CMV-vaccines and other vaccines, and for analysis for research purposes of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for analysis for research purposes of infectious diseases, autoimmunity and for use in connection with toxicological studies and research in relation to transplantation, immune monitoring, vaccines and T-cell monitoring; chemical reagents other than for medicinal and veterinary purposes Preparations for pharmaceutical purposes for treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; preparations for medical purposes for treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; chemical-pharmaceutical preparations for treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; diagnostic preparations for medical purposes; reagents for medical and veterinary purposes; vaccines; chemical preparations for analysis for medical diagnostic purposes in relation to vaccines, immunotherapeutics and cellular therapies, including cancer vaccines and immunotherapeutics, borrelia vaccines, TB-vaccines, HIV-vaccines and CMV-vaccines, T-cell therapies, and for use in connection with cancer therapy and other medical therapies, for analysis and treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for infectious diseases, and for use in connection with medical procedures and diagnosis, namely, transplantation, immune monitoring, and vaccines and T-cell monitoring

Goods & Services

Chemicals used in diagnostics, industry and science; diagnostic reagents for diagnostic (other than medical and veterinary) and scientific purposes; research reagents for scientific and diagnostic purposes; diagnostic test materials for scientific and diagnostic (other than medical and veterinary) purposes; diagnostic kits for scientific and diagnostic (other than medical and veterinary) purposes; assays for research and diagnostic (other than medical and veterinary) purposes; biochemical reagents (other than medical and veterinary); preparations for analysis for research purposes related to vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB-vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, including cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue; preparations for analysis for research purposes related to analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; chemical reagents for other than medicinal and veterinary purposes. Preparations for pharmaceutical purposes; preparations for medical purposes; chemical-pharmaceutical preparations; diagnostic preparations for medical purposes; reagents for medical and veterinary purposes; vaccines; preparations for analysis for medical purposes, hereunder for each of the abovementioned preparations for development or analysis of vaccines, immunotherapeutics and cellular therapies, including cancer vaccines and immunotherapeutics, borrelia vaccines, TB-vaccines, HIV-vaccines and CMV-vaccines, T-cell therapies, or for use in connection with cancer therapy or other therapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for infectious diseases; preparations for analysis for medical purposes, hereunder for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring.

Abstract

Disclosed herein is a panel comprising one or more MHC multimers; and a panel comprising one or more pools of MHC multimers, wherein each pool comprises one or more MHC multimers; wherein said MHC multimers comprise an antigenic peptide P derived from a Borrelia antigenic polypeptide selected from the group consisting of OppA, DbpA, FlhF, FlaB and P37-42; as well as uses thereof in the detection of Borrelia-specific T cells and the diagnosis, treatment and monitoring of Borrelia disease in an individual.

IPC Classes  ?

• C07K 14/74 - Major histocompatibility complex [MHC]
• A61K 39/02 - Bacterial antigens
• C07K 14/20 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
• A61P 31/04 - Antibacterial agents
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Goods & Services

Chemicals used in diagnostics, industry and science; diagnostic reagents for diagnostic (other than medical and veterinary) and scientific purposes; research reagents for scientific and diagnostic purposes; diagnostic test materials for scientific and diagnostic (other than medical and veterinary) purposes; diagnostic kits for scientific and diagnostic (other than medical and veterinary) purposes; assays for research and diagnostic (other than medical and veterinary) purposes; biochemical reagents (other than medical and veterinary); preparations for analysis for research purposes related to vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB-vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, including cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; chemical reagents for other than medicinal and veterinary purposes. Preparations for pharmaceutical purposes; preparations for medical purposes; chemico-pharmaceutical preparations; diagnostic preparations for medical purposes; reagents for medical and veterinary purposes; vaccines; preparations for analysis for medical purposes, hereunder for each of the abovementioned preparations for development or analysis of vaccines, immunotherapeutics and cellular therapies, including cancer vaccines and immunotherapeutics, borrelia vaccines, TB-vaccines, HIV-vaccines and CMV-vaccines, T-cell therapies, or for use in connection with cancer therapy or other therapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for infectious diseases, and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring. Scientific and technological services and research and design relating thereto; diagnostic services related to research; industrial analysis and research services; basic research and clinical research, hereunder for medicine and vaccine development; research and development in the field of diagnostic preparations.

Goods & Services

Chemicals used in diagnostics, industry and science; diagnostic reagents for diagnostic (other than medical and veterinary) and scientific purposes; research reagents for scientific and diagnostic purposes; diagnostic test materials for scientific and diagnostic (other than medical and veterinary) purposes; diagnostic kits for scientific and diagnostic (other than medical and veterinary) purposes; assays for research and diagnostic (other than medical and veterinary) purposes; biochemical reagents (other than medical and veterinary); preparations for analysis for research purposes related to vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB-vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, including cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; chemical reagents for other than medicinal and veterinary purposes. Preparations for pharmaceutical purposes; preparations for medical purposes; chemico-pharmaceutical preparations; diagnostic preparations for medical purposes; reagents for medical and veterinary purposes; vaccines; preparations for analysis for medical purposes, hereunder for each of the abovementioned preparations for development or analysis of vaccines, immunotherapeutics and cellular therapies, including cancer vaccines and immunotherapeutics, borrelia vaccines, TB-vaccines, HIV-vaccines and CMV-vaccines, T-cell therapies, or for use in connection with cancer therapy or other therapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for infectious diseases, and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring.

Goods & Services

(1) Chemicals used in medical diagnostics and treatment in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; diagnostic preparations for medical-scientific research use; diagnostic reagents for medical-scientific research use; diagnostic reagents for use in medical diagnostics applications in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; research reagents for use in medical diagnostics applications in the field of vaccines and Immunotherapy, cancer vaccines, borrelia vaccines, TB vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for analysis of infections diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; diagnostic test materials for use in medical diagnostics applications in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumours and tissue, and for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; diagnostic kits for use in medical diagnostics applications in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TBvaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis and treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; assays for use in medical diagnostics applications in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TBvaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for analysis of infections diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; biochemical reagents for use in medical diagnostics applications in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TBvaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumours and tissue, and for analysis of infections diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; preparations for analysis for research purposes related to vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; chemical reagents for use in medical diagnostics applications in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TBvaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for analysis of infections diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring (2) Preparations for pharmaceutical purposes for treatment of cancer, T-cell lymphoma, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; preparations for medical purposes for treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; chemical-pharmaceutical preparations for treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infections diseases; diagnostic preparations for medical purposes for use in the diagnosis and treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; reagents for medical and veterinary purposes for use in the diagnosis and treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious disease; vaccines; chemical preparations for analysis for medical diagnostic purposes in relation to vaccines, immunotherapeutics and cellular therapies, cancer vaccines and immunotherapeutics, borrelia vaccines, TB-vaccines, HIV-vaccines and CMV-vaccines, T-cell therapies, and for use in connection with cancer therapy and other therapy, for analysis and treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, infectious diseases, and for use in connection with medical procedures and diagnosis, namely transplantation, immune monitoring, and vaccines and T-cell monitoring

Goods & Services

Chemicals used in [ diagnostics, ] industry and science, other than for medical or veterinary purposes; [ diagnostic and ] research reagents for scientific and diagnostic purposes other than medical or veterinary diagnostic purposes; [ diagnostic test materials for scientific and diagnostic purposes other than medical or veterinary diagnostic purposes; diagnostic kits for scientific and diagnostic purposes other than medical or veterinary diagnostic purposes consisting primarily of MHC multimer reagents, monoclonal antibodies, reagents, diagnostic agents, control reagents, DNA/RNA oligo's and DNA/RNA oligo conjugated reagents; ] assays for research and diagnostic purposes other than medical or veterinary diagnostic purposes; biochemical reagents used for non-medical purposes; chemical preparations for analysis for research purposes related to vaccines and immunotherapy, cancer vaccines, [ borrelia vaccines, TB-vaccines, HIV-vaccines, CMV-vaccines ] and other vaccines, and for analysis for research purposes of [ T-cell lymphoma, ] T-cell infiltration of solid tumors and tissue, and for analysis for research purposes of infectious diseases, autoimmunity and for use in connection with toxicological studies and research in relation to transplantation, immune monitoring, vaccines and T-cell monitoring; chemical reagents other than for medicinal and veterinary purposes [ Preparations for pharmaceutical purposes for treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; preparations for medical purposes for treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; chemical-pharmaceutical preparations for treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; diagnostic preparations for medical purposes; reagents for medical and veterinary purposes; vaccines; chemical preparations for analysis for medical diagnostic purposes in relation to vaccines, immunotherapeutics and cellular therapies, including cancer vaccines and immunotherapeutics, borrelia vaccines, TB-vaccines, HIV-vaccines and CMV-vaccines, T-cell therapies, and for use in connection with cancer therapy and other medical therapies, for analysis and treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for infectious diseases, and for use in connection with medical procedures and diagnosis, namely, transplantation, immune monitoring, and vaccines and T-cell monitoring ]

Goods & Services

(1) Chemicals used in medical diagnostics and treatment in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; diagnostic preparations for medical-scientific research use; diagnostic reagents for medical-scientific research use; diagnostic reagents for use in medical diagnostics applications in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; research reagents for use in medical diagnostics applications in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; diagnostic test materials for use in medical diagnostics applications in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB vaccines, HIV vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumours and tissue, and for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T cell monitoring; diagnostic kits for use in medical diagnostics applications in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TBvaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; assays for use in medical diagnostics applications in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TBvaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; biochemical reagents for use in medical diagnostics applications in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TBvaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; preparations for analysis for research purposes related to vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TBvaccines, HIV-vaccines, CMVvaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; chemical reagents for use in medical diagnostics applications in the field of vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TBvaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring (2) Preparations for pharmaceutical purposes for treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; preparations for medical purposes for treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; chemical-pharmaceutical preparations for treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; diagnostic preparations for medical purposes for use in the diagnosis and treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; reagents for medical and veterinary purposes for use in the diagnosis and treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; vaccines; chemical preparations for analysis for medical diagnostic purposes in relation to vaccines, immunotherapeutics and cellular therapies, cancer vaccines and immunotherapeutics, borrelia vaccines, TB-vaccines, HIV-vaccines and CMV-vaccines, T-cell therapies, and for use in connection with cancer therapy and other therapy, for analysis and treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, infectious diseases, and for use in connection with medical procedures and diagnosis, namely transplantation, immune monitoring, and vaccines and T-cell monitoring (1) Scientific and technological services and research and design services in the field of medicine and vaccine development; diagnostic services related to research in the field of medicine and vaccine development; industrial analysis and research services in the field of medicine and vaccine development; basic research and clinical research, hereunder for medicine and vaccine development; research and development in the field of diagnostic preparations in the field of medicine and vaccine development

Goods & Services

Chemicals used in diagnostics, industry and science; diagnostic reagents for diagnostic (other than medical and veterinary) and scientific purposes; research reagents for scientific and diagnostic purposes; diagnostic test materials for scientific and diagnostic (other than medical and veterinary) purposes; diagnostic kits for scientific and diagnostic (other than medical and veterinary) purposes; assays for research and diagnostic (other than medical and veterinary) purposes; biochemical reagents (other than medical and veterinary); preparations for analysis for research purposes related to vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB-vaccines, HIV-vaccines, CMV-vaccines and other vaccines; or for use in connection with therapy and immunotherapy, including cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; chemical reagents for other than medicinal and veterinary purposes. Preparations for pharmaceutical purposes; preparations for medical purposes; chemical-pharmaceutical preparations; diagnostic preparations for medical purposes; reagents for medical and veterinary purposes; vaccines; preparations for analysis for medical purposes, hereunder for each of the abovementioned preparations for development or analysis of vaccines, immunotherapeutics and cellular therapies, including cancer vaccines and immunotherapeutics, borrelia vaccines, TB-vaccines, HIV-vaccines and CMV-vaccines, T-cell therapies; or for use in connection with cancer therapy or other therapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for infectious diseases, and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring.

Goods & Services

Chemicals used in diagnostics, industry and science, other than for medical or veterinary purposes; diagnostic and research reagents for scientific and diagnostic purposes other than medical or veterinary diagnostic purposes; diagnostic test materials for scientific and diagnostic purposes other than medical or veterinary diagnostic purposes; diagnostic kits for scientific and diagnostic purposes other than medical or veterinary diagnostic purposes consisting primarily of MHC multimer reagents, monoclonal antibodies, reagents, diagnostic agents, control reagents,[ DNA/RNA oligo's and ] DNA/RNA oligo conjugated reagents; assays for research and diagnostic purposes other than medical or veterinary diagnostic purposes; biochemical reagents used for non-medical purposes; chemical preparations for analysis for research purposes related to vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB-vaccines, HIV-vaccines, CMV-vaccines and other vaccines, and for analysis for research purposes of [T-cell lymphoma,] T-cell infiltration of solid tumors and tissue, and for analysis for research purposes of infectious diseases, autoimmunity and for use in connection with toxicological studies and research in relation to transplantation, immune monitoring, vaccines and T-cell monitoring; chemical reagents other than for medicinal and veterinary purposes [ Preparations for pharmaceutical purposes for treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; preparations for medical purposes for treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases; chemical-pharmaceutical preparations for treatment of cancer, T-cell lymphoma, T-cell infiltration of solid tumors and tissue, T-cell diseases in blood, transplantation related diseases and diseases related to immune suppression, autoimmune disease and infectious diseases;] diagnostic preparations for medical purposes; reagents for medical and veterinary purposes; vaccines; chemical preparations for analysis for medical diagnostic purposes in relation to vaccines, immunotherapeutics and cellular therapies, including cancer vaccines and immunotherapeutics, borrelia vaccines, TB-vaccines, HIV-vaccines and CMV-vaccines, T-cell therapies, and for use in connection with cancer therapy and other medical therapies, for analysis and treatment o [T-cell lymphoma,] T-cell infiltration of solid tumors and tissue, and for infectious diseases, and for use in connection with medical procedures and diagnosis, namely transplantation, immune monitoring, and vaccines and T-cell monitoring Scientific research services; diagnostic services related to scientific research; basic research and clinical research in relation to medicine and vaccine development; research and development in the field of diagnostic preparations

Abstract

The present invention relates to detection molecules comprising at least one binding molecule, at least one linker and at least one label, and detection methods making use of same. The invention provides a high-throughput method for detection, isolation and/or identification of specific entities or cells.

IPC Classes  ?

• G01N 33/532 - Production of labelled immunochemicals
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• G01N 33/533 - Production of labelled immunochemicals with fluorescent label

Goods & Services

Chemicals used in diagnostics, industry and science; diagnostic reagents for diagnostic (other than medical and veterinary) and scientific purposes; research reagents for scientific and diagnostic purposes; diagnostic test materials for scientific and diagnostic (other than medical and veterinary) purposes; diagnostic kits for scientific and diagnostic (other than medical and veterinary) purposes; assays for research and diagnostic (other than medical and veterinary) purposes; biochemical reagents (other than medical and veterinary); preparations for analysis for research purposes related to vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB-vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, including cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; chemical reagents for other than medicinal and veterinary purposes. Preparations for pharmaceutical purposes; preparations for medical purposes; chemical-pharmaceutical preparations; diagnostic preparations for medical purposes; reagents for medical and veterinary purposes; vaccines; preparations for analysis for medical purposes, hereunder for each of the abovementioned preparations for development or analysis of vaccines, immunotherapeutics and cellular therapies, including cancer vaccines and immunotherapeutics, borrelia vaccines, TB-vaccines, HIV-vaccines and CMV-vaccines, T-cell therapies, or for use in connection with cancer therapy or other therapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for infectious diseases, and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring. Scientific and technological services and research and design relating thereto; diagnostic services related to research; industrial analysis and research services; basic research and clinical research, hereunder for medicine and vaccine development; research and development in the field of diagnostic preparations.

Goods & Services

Chemicals used in diagnostics, industry and science; diagnostic reagents for diagnostic (other than medical and veterinary) and scientific purposes; research reagents for scientific and diagnostic purposes; diagnostic test materials for scientific and diagnostic (other than medical and veterinary) purposes; diagnostic kits for scientific and diagnostic (other than medical and veterinary) purposes; assays for research and diagnostic (other than medical and veterinary) purposes; biochemical reagents (other than medical and veterinary); preparations for analysis for research purposes related to vaccines and immunotherapy, cancer vaccines, borrelia vaccines, TB-vaccines, HIV-vaccines, CMV-vaccines and other vaccines, or for use in connection with therapy and immunotherapy, including cancer therapy, cancer immunotherapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for analysis of infectious diseases, autoimmunity and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring; chemical reagents for other than medicinal and veterinary purposes. Preparations for pharmaceutical purposes; preparations for medical purposes; chemical-pharmaceutical preparations; diagnostic preparations for medical purposes; reagents for medical and veterinary purposes; vaccines; preparations for analysis for medical purposes, hereunder for each of the abovementioned preparations for development or analysis of vaccines, immunotherapeutics and cellular therapies, including cancer vaccines and immunotherapeutics, borrelia vaccines, TB-vaccines, HIV-vaccines and CMV-vaccines, T-cell therapies, or for use in connection with cancer therapy or other therapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for infectious diseases, and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring.

Abstract

The present invention describes the use of nucleic acid barcodes as specific labels for MHC multimers to determine the antigen responsiveness in biological samples. After cellular selection the barcode sequence will be revealed by sequencing. This technology allows for detection of multiple (potentially >1000) different antigen-specific cells in a single sample. The technology can be used for T-cell epitope mapping, immune-recognition discovery, diagnostics tests and measuring immune reactivity after vaccination or immune-related therapies.

IPC Classes  ?

• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• C07K 19/00 - Hybrid peptides
• C07K 14/74 - Major histocompatibility complex [MHC]
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

The present invention relates to detection molecules comprising at least one binding molecule, at least one linker and at least one label, and detection methods making use of same. The invention provides a high-throughput method for detection, isolation and/or identification of specific entities or cells.

IPC Classes  ?

• G01N 33/533 - Production of labelled immunochemicals with fluorescent label
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Abstract

The present invention describes the use of nucleic acid barcodes as specific labels for MHC multimers to determine the antigen responsiveness in biological samples. After cellular selection the barcode sequence will be revealed by sequencing. This technology allows for detection of multiple (potentially >1000) different antigen-specific cells in a single sample. The technology can be used for T-cell epitope mapping, immune-recognition discovery, diagnostics tests and measuring immune reactivity after vaccination or immune-related therapies.

IPC Classes  ?

• C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
• C07K 14/74 - Major histocompatibility complex [MHC]
• C07K 19/00 - Hybrid peptides
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• C40B 30/04 - Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
• C40B 70/00 - Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or barcodes
• G01N 33/566 - ImmunoassayBiospecific binding assayMaterials therefor using specific carrier or receptor proteins as ligand binding reagent

Abstract

The present invention describes the use of nucleic acid barcodes as specific labels for MHC multimers to determine the antigen responsiveness in biological samples. After cellular selection the barcode sequence will be revealed by sequencing. This technology allows for detection of multiple (potentially >1000) different antigen-specific cells in a single sample. The technology can be used for T-cell epitope mapping, immune-recognition discovery, diagnostics tests and measuring immune reactivity after vaccination or immune-related therapies.

IPC Classes  ?

• C07H 21/00 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
• C07K 14/74 - Major histocompatibility complex [MHC]
• C12N 15/11 - DNA or RNA fragmentsModified forms thereof
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• C40B 30/04 - Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
• C40B 40/10 - Libraries containing peptides or polypeptides, or derivatives thereof
• C40B 70/00 - Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or barcodes
• G01N 33/566 - ImmunoassayBiospecific binding assayMaterials therefor using specific carrier or receptor proteins as ligand binding reagent

Abstract

The present invention describes the use of nucleic acid barcodes as specific labels for MHC multimers to determine the antigen responsiveness in biological samples. After cellular selection the barcode sequence will be revealed by sequencing. This technology allows for detection of multiple (potentially >1000) different antigen-specific cells in a single sample. The technology can be used for T-cell epitope mapping, immune-recognition discovery, diagnostics tests and measuring immune reactivity after vaccination or immune-related therapies.

IPC Classes  ?

• C07K 14/74 - Major histocompatibility complex [MHC]
• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
• C12N 15/10 - Processes for the isolation, preparation or purification of DNA or RNA
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses

Goods & Services

Preparations for pharmaceutical purposes, preparations for medical purposes, chemical preparations for pharmaceutical purposes, diagnostic preparations for medical purposes, reagents for medical and veterinary purposes and for research, medical preparations including for research and analysis purposes, hereunder for each of the abovementioned preparations for development or analysis of cancer vaccines, borrella vaccines, TB vaccines, HIV vaccines and CMV vaccines, or for use in connection with cancer therapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for infectious diseases, and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring. Scientific and technological services and research and design relating thereto; industrial analysis and research services; basic research and clinical research, hereunder for medicine and vaccine development.

Abstract

A method for the repair of a unit, by specific diagnosis of the undesired state, and its appropriate repair, using said specific diagnosis as a means to repair in an appropriate way said unit. The diagnosis and repair processes may involve chemical, physical, or mechanical means. The units being diagnosed and repaired include live matter (e.g. human beings, animals, plants) as well as non-live matter (e.g. buildings, electronic equipment, polymer materials).

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/02 - Bacterial antigens

Goods & Services

Preparations for pharmaceutical purposes, preparations for medical purposes, chemical-pharmaceutical preparations, diagnostic preparations for medical purposes, reagents for medical and veterinary purposes and for research, preparations for analysis for medical and research purposes, hereunder for each of the abovementioned preparations for development or analysis of cancer vaccines, borrelia vaccines, TB vaccines, HIV vaccines and CMV vaccines, or for use in connection with cancer therapy, for analysis or treatment of T-cell lymphoma, T-cell infiltration of solid tumors and tissue, and for infectious diseases, and for use in connection with toxicological studies, transplantation, immune monitoring, or vaccines and T-cell monitoring. Scientific and technological services and research and design relating thereto; industrial analysis and research services; basic research and clinical research, hereunder for medicine and vaccine development.

Goods & Services

Preparations for pharmaceutical purposes, pharmaceutical preparations for medical purposes, and chemical-pharmaceutical preparations, namely vaccines and for treating infections caused by CMV, LCMV, EBV, HIV, HPV, BK polyomavirus, HTLV, Hepatitis B, Hepatitis C, TB, Graft versus Host Disease, Diabetes, JC Polyomavirus, HHV-3 (Human Herpes Virus), Influenza, Murine Herpes, Malaria, Murine Polyomavirus, RSV, HPV, Herpes Simplex Virus II, Sendai Virus, M Bovis, Vesicular Stromatitis Virus, Vaccinia Virus, Toxoplasmosis, Trypanosomacruzi, SIV, and vaccines and treatments for cancer, diabetes, arthritis, schlerosis, Achlorhydra Autoimmune Active Chronic Hepatitis, Acute Disseminated Encephalomyelitis, Acute hemorrhagic leukoencephalitis, Addison's Disease, Agammaglobulinemia, Alopecia areata, Amyotrophic Lateral Sclerosis, Ankylosing Spondylitis, Anti-GBM/TBM Nephritis, Antiphospholipid syndrome, Antisynthetase syndrome, Arthritis, Atopic allergy, Atopic Dermatitis, Autoimmune Aplastic Anemia, Autoimmune cardiomyopathy, Autoimmune hemolytic anemia, Autoimmune hepatitis, Autoimmune inner ear disease, Autoimmune lymphoproliferative syndrome, Autoimmune peripheral neuropathy, Autoimmune pancreatitis, Autoimmune polyendocrine syndrome Types I, II, and III, Autoimmune progesterone dermatitis, Autoimmune thrombocytopenic purpura, Autoimmune uveitis, Balo disease/Balo concentric sclerosis, Bechets Syndrome, Berger's disease, Bickerstaff's encephalitis, Blau syndrome, Bullous Pemphigoid, Castleman's disease, Chagas disease, Chronic Fatigue Immune Dysfunction Syndrome, Chronic antiflammatory demyelinating polyneuropathy, Chronic recurrent multifocal ostomyelitis, Chronic lyme disease, Chronic obstructive pulmonary disease, Churg-Strauss syndrome, CicatricialPemphigoid, Coeliac disease, Cogan syndrome, old agglutinin disease, Complement component 2 deficiency, Cranial arteritis, CREST syndrome, Crohns Disease, Cushing's Syndrome, Cutaneous leukocytoclasticangiitis, Dego's disease, Dercum's disease, Dermatitis herpetiformis, Dermatomyositis, Diabetes mellitus type 1, Diffuse cutaneous systemic sclerosis, Dressler's syndrome, Discoid lupus erythematosus, Eczema, Endometriosis, Enthesitis-related arthritis, Eosinophilic fasciitis, Epidermolysisbullosaacquisita, Erythema nodosum, Essential mixed cryoglobulinemia, Evan's syndrome, Fibrodysplasiaossificans progressive, Fibromyalgia, Fibromyositis, Fibrosingaveolitis, Gastritis, Gastrointestinal pemphigoid, Giant cell arteritis, Glomerulonephritis, Goodpasture's syndrome, Graves' disease, Guillain-Barré syndrome (GBS), Hashimoto's encephalitis, Hashimoto's thyroiditis, Haemolyticanemia, Henoch-Schonleinpurpura, Herpes gestationis, Hidradenitissuppurativa, Hughes syndrome, Hypogammaglobulinemia, Idiopathic Inflammatory Demyelinating Diseases, Idiopathic pulmonary fibrosis, Idiopathic thrombocytopenic purpura, IgA nephropathy (Berger's disease), Inclusion body myositis, Inflammatory demyelinating , olyneuopathy, Interstitial cystitis, Irritable Bowel Syndrome (IBS), Juvenile idiopathic arthritis, Juvenile heumatoid arthritis, Kawasaki's Disease, Lambert-Eaton myasthenic syndrome, Leukocytoclasticvasculitis, Lichen planus, Lichen sclerosus, Linear IgA disease (LAD), Lou Gehrig's Disease (Amyotrophic lateral sclerosis), Lupoid hepatitis, Lupus erythematosus, Majeed syndrome, Ménière's disease, Microscopic, polyangiitis, Miller-Fisher syndrome, Mixed Connective Tissue Disease, Morphea, Mucha-Habermann disease, Muckle-Wells syndrome, Multiple Myeloma, Multiple Sclerosis, Myasthenia gravis, Myositis, Narcolepsy, Neuromyelitisoptica(Devic's Disease), Neuromyotonia, Occularcicatricialpemphigoid, Opsoclonus myoclonus syndrome, Ord's thyroiditis, Palindromic rheumatism, PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus), Paraneoplastic cerebellar degeneration, Paroxysmal nocturnal hemoglobinuria (PNH), Parry Romberg syndrome, Parsonnage-Turner syndrome, Pars planitis, Pemphigus, Pemphigus vulgaris, Pernicious anaemia, Perivenous encephalomyelitis, POEMS syndrome, Polyarteritisnodosa, Polymyalgia rheumatic, Polymyositis, Primary biliary cirrhosis, Primary sclerosing cholangitis, Progressive inflammatory neuropathy, Psoriasis, Psoriatic Arthritis,Pyodermagangrenosum, Pure red cell aplasia, Rasmussen's encephalitis, Raynaud phenomenon, Relapsing polychondritis, Reiter's syndrome, Restless leg syndrome, Retroperitoneal fibrosis, Rheumatoid arthritis, Rheumatoid fever, Sarcoidosis, Schizophrenia, Schmidt syndrome, Schnitzler syndrome, Scleritis, Scleroderma, Sjögren's syndrome, Spondyloarthropathy, Sticky blood syndrome, Still's Disease, Stiff person syndrome, Subacute bacterial endocarditis (SBE), Susac's syndrome, Sweet syndrome, Sydenham Chorea, Sympathetic ophthalmia, Takayasu's arteritis, Temporal arteritis (giant cell arteritis), Tolosa-Hunt syndrome, Transverse Myelitis, Ulcerative Colitis, Undifferentiated connective tissue disease, Undifferentiated spondyloarthropathy, Vasculitis, Vitiligo, Wegener's granulomatosis, Wilson's syndrome, Wiskott-Aldrich syndrome, T-cell lymphoma, and T-cell infiltration of solid tumors and tissue; diagnostic preparations for medical purposes, reagents for medical and veterinary purposes and for research, preparations for analysis for medical and research purposes, hereunder for each of the abovementioned preparations for development and analysis of vaccines and treatments targeting infections by CMV, LCMV, EBV, HIV, HPV, BK polyomavirus, HTLV, Hepatitis B, Hepatitis C, TB, Graft versus Host Disease, Diabetes, JC Polyomavirus, HHV-3 (Human Herpes Virus), Influenza, Murine Herpes, Malaria, Murine Polyomavirus, RSV, HPV, Herpes Simplex Virus II, Sendai Virus, M Bovis, Vesicular Stromatitis Virus, Vaccinia Virus, Toxoplasmosis, Trypanosomacruzi, SIV, and vaccines and treatments for cancer, diabetes, arthritis, schlerosis, Achlorhydra Autoimmune Active Chronic Hepatitis, Acute Disseminated Encephalomyelitis, Acute hemorrhagic leukoencephalitis, Addison's Disease, Agammaglobulinemia, Alopecia areata, Amyotrophic Lateral Sclerosis, Ankylosing Spondylitis, Anti-GBM/TBM Nephritis, Antiphospholipid syndrome, Antisynthetase syndrome, Arthritis, Atopic allergy, Atopic Dermatitis, Autoimmune Aplastic Anemia, Autoimmune cardiomyopathy, Autoimmune hemolytic anemia, Autoimmune hepatitis, Autoimmune inner ear disease, Autoimmune lymphoproliferative syndrome, Autoimmune peripheral neuropathy, Autoimmune pancreatitis, Autoimmune polyendocrine syndrome Types I, II, and III, Autoimmune progesterone dermatitis, Autoimmune thrombocytopenic purpura, Autoimmune uveitis, Balo disease/Balo concentric sclerosis, Bechets Syndrome, Berger's disease, Bickerstaff's encephalitis, Blau syndrome, Bullous Pemphigoid, Castleman's disease, Chagas disease, Chronic Fatigue Immune Dysfunction Syndrome, Chronic inflammatory demyelinating polyneuropathy, Chronic recurrent multifocal ostomyelitis, Chronic lyme disease, Chronic obstructive pulmonary disease, Churg-Strauss syndrome, CicatricialPemphigoid, Coeliac disease, Cogan syndrome, old agglutinin disease, Complement component 2 deficiency, Cranial arteritis, CREST syndrome, Crohns Disease, Cushing's Syndrome, Cutaneous leukocytoclasticangiitis, Dego's disease, Dercum's disease, Dermatitis herpetiformis, Dermatomyositis, Diabetes mellitus type 1, Diffuse cutaneous systemic sclerosis, Dressler's syndrome, Discoid lupus erythematosus, Eczema, Endometriosis, Enthesitis-related arthritis, Eosinophilic fasciitis, Epidermolysisbullosaacquisita, Erythema nodosum, Essential mixed cryoglobulinemia, Evan's syndrome, Fibrodysplasiaossificans progressive, Fibromyalgia, Fibromyositis, Fibrosingaveolitis, Gastritis, Gastrointestinal pemphigoid, Giant cell arteritis, Glomerulonephritis, Goodpasture's syndrome, Graves' disease, Guillain-Barré syndrome (GBS), Hashimoto's encephalitis, Hashimoto's thyroiditis, Haemolytic anemia,Henoch-Schonleinpurpura, Herpes gestationis, Hidradenitissuppurativa, Hughes syndrome, Hypogammaglobulinemia, Idiopathic Inflammatory Demyelinating Diseases, Idiopathic pulmonary fibrosis, Idiopathic thrombocytopenic purpura, IgA nephropathy (Berger's disease), Inclusion body myositis, Inflammatory demyelinating, olyneuopathy, Interstitial cystitis, Irritable Bowel Syndrome (IBS), Juvenile idiopathic arthritis, Juvenile heumatoid arthritis, Kawasaki's Disease, Lambert-Eaton myasthenic syndrome, Leukocytoclasticvasculitis, Lichen planus, Lichen sclerosus, Linear IgA disease (LAD), Lou Gehrig's Disease (Amyotrophiclateral sclerosis), Lupoid hepatitis, Lupus erythematosus, Majeed syndrome, Ménière's disease, Microscopic polyangiitis, Miller-Fisher syndrome, Mixed Connective Tissue Disease, Morphea, Mucha-Habermann disease, Muckle-Wells syndrome, Multiple Myeloma, Multiple Sclerosis, Myasthenia gravis, Myositis, Narcolepsy, Neuromyelitisoptica (Devic's Disease), Neuromyotonia, Occularcicatricialpemphigoid, Opsoclonus myoclonus syndrome, Ord's thyroiditis, Palindromic rheumatism, PANDAS (Pediatric autoimmune Neuropsychiatric Disorders Associated withStreptococcus), Paraneoplastic cerebellar degeneration, Paroxysmal nocturnal hemoglobinuria (PNH), Parry Romberg syndrome, Parsonnage-Turner syndrome, Pars planitis, Pemphigus, Pemphigus vulgaris, Pernicious anaemia, Perivenous encephalomyelitis, POEMS syndrome, Polyarteritisnodosa, Polymyalgia rheumatic, Polymyositis, Primary biliary cirrhosis, Primary sclerosing cholangitis, Progressive inflammatory neuropathy, Psoriasis, Psoriatic Arthritis, Pyodermagangrenosum, Pure red cell aplasia, Rasmussen's encephalitis, Raynaud phenomenon, Relapsingpolychondritis, Reiter's syndrome, Restless leg syndrome, Retroperitoneal fibrosis, Rheumatoid arthritis, Rheumatoid fever, Sarcoidosis, Schizophrenia, Schmidt syndrome, Schnitzler syndrome, Scleritis, Scleroderma, Sjögren's syndrome, Spondyloarthropathy, Sticky blood syndrome, Still's Disease, Stiff person syndrome, Subacute bacterial endocarditis (SBE), Susac's syndrome, Sweet syndrome, Sydenham Chorea, Sympathetic ophthalmia, Takayasu's arteritis, Temporal arteritis (giant cell arteritis), Tolosa-Hunt syndrome, Transverse Myelitis, Ulcerative Colitis, Undifferentiated connective tissue disease, Undifferentiated spondyloarthropathy, Vasculitis, Vitiligo, Wegener's granulomatosis, Wilson's syndrome, Wiskott-Aldrich syndrome, T-cell lymphoma, and T-cell infiltration of solid tumors and tissue, and for use in connection with toxicological studies, transplantation, immune monitoring, and vaccines and T-cell monitoring Scientific and technological services and research and design relating thereto in the field of vaccines, immunotherapy, and the measurement of immune responses; industrial analysis and research services in the field of vaccines, immunotherapy, and the measurement of immune responses; basic research and clinical research in the field of medicine and vaccine development