The present disclosure relates generally to the assessment and treatment of vessels, including for percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG). For example, some embodiments of the present disclosure are suited for identifying the available intervention technique(s) suitable to achieve a desired outcome selected or input by a user. For example, in some implementations a method comprises receiving pressure measurements obtained by one or more intravascular pressure-sensing instruments positioned within a vessel of a patient; receiving an input from a user regarding a desired pressure value for the vessel of the patient; identifying an available treatment option based on the received pressure measurements and the desired pressure value; and outputting, to a display device, a screen display including a visual representation of the available treatment option. Related devices and systems are also described.
A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
A61B 5/0215 - Measuring pressure in heart or blood vessels by means inserted into the body
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
2.
APPARATUS AND METHOD FOR INSERTING ELECTRODE-BASED PROBES INTO BIOLOGICAL TISSUE
A probe assembly comprising: an electrode-based probe comprising a probe head and one or more slender electrodes extending from the probe head for insertion into biological tissue; and a support element disposed around one or more of said electrodes, distal from the probe head, the support element comprising one or more apertures through which said one or more electrodes pass, the probe head and said electrode(s) being movable relative to the support element during insertion; wherein the support element is configured to constrain the angle of the end of the said electrode(s) at the point of insertion into the tissue. Also provided is an insertion device for inserting the electrode(s) of such a probe assembly into biological tissue, the insertion device comprising: means for holding the support element against the tissue or in close proximity to the tissue; and means for applying an insertion force to the probe head, to drive the probe head towards the support element and thereby cause the electrode(s) to move through the aperture(s) in the support element and become inserted into the tissue.
An implantable intracardiac apparatus for implantation in a wall of the heart to secure a pressure sensor thereto, the apparatus comprising: a mesh configured to collapse to enable it to be carried, by a catheter, to a deployment site in the heart, and to expand upon deployment from the catheter to provide a conformable mesh layer for securement against the wall of the heart; wherein the conformable mesh layer comprises an opening occupied by a compliant diaphragm that is flush with the mesh layer, or recessed with respect to the mesh layer, when the mesh layer is secured against the wall of the heart; the apparatus further comprising a can for holding said pressure sensor, and the compliant diaphragm provides a wall of the can.
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE (United Kingdom)
IMPERIAL INNOVATIONS LIMITED (United Kingdom)
IP2IPO INNOVATIONS LTD. (United Kingdom)
Inventor
Edelson-Averbukh, Marina
Averbukh, Vitali
Driver, Taran
Ayers, Ruth
Frasinski, Leszek
Klug, David
Marangos, Jon
Abstract
mpp /Zpp p ; b) dividing each spectra into a plurality of m/z bins; c) determining a covariance or a partial covariance between different bins across the plurality of spectra and correlating the fluctuations of measured intensities in each bin; d) determining a statistical significance of each correlation to identify one or more true ion correlation peaks; e) obtaining a plurality of ion fragmentation patterns for one or more candidate parent ions; f) comparing the true ion correlation peaks to the candidate parent ion fragmentation patterns to determine if the candidate parent ion and the first parent ion are the same.
An implantable cardiovascular pressure sensor comprising a rigid enclosure sealed by a flexible membrane; and an elongate compliant member comprising a piezoelectric material, the member having a width and a length greater than the width, and two ends separated by the length and two sides separated by the width;wherein the flexible membrane is coupled to the elongate compliant member to transfer external fluid pressure load to the elongate compliant member to cause deflection of the elongate compliant member in response to changes in the external fluid pressure;the pressure sensor further comprising a first acoustic wave device provided by the piezoelectric material of the elongate compliant member for sensing said deflection.
A61B 5/0215 - Measuring pressure in heart or blood vessels by means inserted into the body
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
B81C 1/00 - Manufacture or treatment of devices or systems in or on a substrate
A61B 5/03 - Measuring fluid pressure within the body other than blood pressure, e.g. cerebral pressure
G01L 9/00 - Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by electric or magnetic pressure-sensitive elementsTransmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means
A method of automatically monitoring electrophysiological data in the brain and detecting clinically significant events comprises receiving signal inputs from at least one or more electrophysiological signal channels each indicative of electrical brain activity. For each of the one or more electrophysiological signal channels, the signals are filtered to obtain a first subchannel having a first frequency range and a second subchannel having a second frequency range. Appearance of a succession of correlated, non-synchronous events are detected in the waveforms of the one or more first subchannels to create a first detection output. Suppression of an amplitude of the signal is detected in one or more of the second subchannels correlated with the detected events in the one or more first subchannels to create a second detection output. The detected events are classified as a predetermined type of clinically significant event according to the first and second detection outputs. Spreading depolarization waves, peri-infarct depolarizations and other clinically significant events may be classified and displayed.
A surgical instrument having a proximal end, a distal end and a shaft, the shaft comprising a plurality of joint components connected in series, each joint component comprising first and second connectors, which connectors are axially spaced apart from one another at first and second ends of a respective joint component, characterised in that the first connector comprises a first rolling surface, and the second connector comprise a second rolling surface, and wherein each joint component comprises a first spur gear extending from the first rolling surface, and a second spur gear extending from the second rolling surface, wherein the first rolling surface of a first joint component is engageable with the second rolling surface of a second joint component to form a rolling joint, and the second rolling surface of the first joint component is engageable with a first rolling surface of a third rolling joint.
Herein is disclosed, a rechargeable flow battery, wherein the flow battery comprises: first and second electrodes, separated such that ions are allowed to flow between them, wherein a first reservoir comprising or for holding a first fluid electrolyte is fluidly connected to the first electrode, to allow circulation of the first fluid electrolyte from the first reservoir to the first electrode and from the first electrode to the first reservoir; and a first current collector comprising a layer of electrically conductive material having opposing first and second sides, wherein the first electrode is disposed on the first side of the first current collector, such that electrons can flow from the electrode to the first current collector, and a first layer of dielectric material is disposed on the second side of the first current collector.
The invention relates to novel biological markers for diseases associated with accelerated aging, such as accelerated lung aging, chronic obstructive pulmonary disease (COPD), ischemic heart disease and renal disease, and in particular to the use of microRNAs as diagnostic and prognostic markers in assays for detecting such disorders. The invention extends to the use of the novel biomarkers as a therapeutic target for treating any diseases associated with accelerated aging, and to methods of determining the efficacy of treating a disorder characterised by accelerated aging with a therapeutic agent, as well as kits for carrying out the assays and methods. The assays are qualitative and/or quantitative, and are adaptable to large-scale screening and clinical trials.
A method of determining a measure of wave speed or wave intensity in a fluid conduit uses ultrasound measurements to determine the conduit diameter, as a function of time, at a longitudinal position of the conduit, and uses ultrasound measurements to determine a measure of fluid velocity, as a function of time, in a volume element at said longitudinal position of the conduit. The ultrasound measurement to determine the measure of fluid velocity is effected by decorrelation of scattering objects within the fluid flow in successive frames sampling the volume element. A wave speed may be determined from a ratio of the change in fluid velocity at the longitudinal position as a function of time and the change in a logarithmic function of the conduit diameter as a function of time. A measure of wave intensity may be determined as a function of change in determined conduit diameter and corresponding change in fluid velocity.
A method of analysing a structure of a composition of matter in a sample includes obtaining a data set comprising a plurality of spectra from the composition, from a first method of analysis, dividing each of the spectra into a plurality of bins, determining a control parameter or parameters indicative of synchronised fluctuations in signal intensity across some or all channels, resulting in universal correlation between said bins, and determining a partial covariance of different bins across the plurality of spectra using the control parameter to correct the correlation of intensity fluctuations between said bins.
G16B 15/00 - ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
G16C 20/20 - Identification of molecular entities, parts thereof or of chemical compositions
H01J 49/00 - Particle spectrometers or separator tubes
G16C 20/70 - Machine learning, data mining or chemometrics
12.
METHODS AND MATERIALS FOR THE DETECTION OF LATENT TUBERCULOSIS INFECTION
There are provided methods of method of determining the latent tuberculosis (TB) infection status in an individual comprising: (i) providing a sample comprising T-cells; (ii) exposing the sample of (i) to one or more TB antigens; (iii) identifying T-cells in the sample that are CD4 positive and secrete IFN-y in response to TB antigens; (iv) identifying those cells of (iii) which are also HLA-DR positive; and optionally (v) calculating the cells identified in (iv) as a percentage of those identified in (iii); wherein the identification of cells in (iv) and/or the percentage of cells calculated in (v) correlates to latent TB infection status of the individual, and wherein steps (iii) and (iv) can be carried out either sequentially or simultaneously. There are also provided compositions and kits for use in such methods.
An ear examination tool comprises a handle and a speculum mount coupled to the handle. The speculum mount is configured for retaining a disposable speculum. An spacing element is coupled to the handle and extends from the handle. A smartphone mount is coupled to the spacing element, and the spacing element is configured to maintain an optical separation distance between the speculum mount and the smartphone mount. The tool enables a clear view of the ear canal while allowing access by, and manipulation of, a microsuction tool being inserted into the ear canal. The extensive optical and data processing functionality of a "smartphone" can be integrated at low cost into an ear examination tool to provide a substantially improved piece of equipment for assisting in ear examination and microsuction of the ear.
A61B 1/04 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor combined with photographic or television appliances
A61B 1/227 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor for ears, i.e. otoscopes
A61B 1/32 - Devices for opening or enlarging the visual field, e.g. of a tube of the body
Analogues of PYY differing from native human PYY by substitution of Ser23 with Ala23, Glu23, Lys23, Gln23 or AIB23. Further optional features include substitutions at further positions, loss of the Tyr1 residue of native human PYY and amidation of the C-terminus. Suitable for use as pharmaceuticals for treating and preventing disorders, in particular diabetes and obesity.
A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
The invention provides novel compounds which are peptide hormone analogues, and which are useful in treating disorders such as diabetes and obesity. The compounds of the general sequence recited in the specification possess a tailored profile with regards to potency properties at the glucagon and GLP-1 receptors. With regard to in vivo properties, administration of example peptides of the invention has been shown, in animal models, to result in increased weight loss.
A sewing device comprising: a curved needle having a first end and a second end, a first point at the first end and a second point at the second end, the needle further comprising a thread receiving portion; a first jaw and a second jaw, which jaws are moveable between an open position and a closed position, the first jaw being adapted to releasably hold the first end of the needle, and the second jaw being adapted to releasably hold the second end of the needle; a lock mechanism comprising a first lock for locking the needle in the first jaw, and a second lock for locking the needle in the second jaw.
A61B 17/04 - Surgical instruments, devices or methods for closing wounds or holding wounds closedAccessories for use therewith for suturing woundsHolders or packages for needles or suture materials
The present invention relates to a method for the diagnosis of sarcoidosis. In particular, the present invention relates to a method for the differential diagnosis of sarcoidosis versus tuberculosis infection.
The invention relates to the detection of biomarkers, and methods, compositions and kits for the detection of such biological markers for diagnosing various conditions, such as cancer. In particular, the invention relates to the detection of compounds as diagnostic and prognostic markers for detecting cancer, such as oesophago-gastric cancer.
A haptic device comprises an active surface comprising a tactile transducer configured to generate variable tactile modulation of the active surface according to a control signal. A physical property sensor is configured to determine a physical property of a target surface adjacent to the haptic device and to provide a surface characteristic signal indicative of the physical property thereof. A controller is configured to receive the surface characteristic signal from the physical property sensor and to generate the control signal as a function of the physical property of the target surface to thereby drive modulation of the active surface.
A sensor device comprising one or more sensors configured to measure data, a controller and memory. The controller comprises an arithmetic-logic unit "ALU". The controller is configured to cause the ALU to carry out computations for implementing an artificial neural network "ANN" comprising a network of interconnected nodes. The memory is coupled to the ALU, and is configured to store integers representing weights associated with interconnects between the nodes. The controller is operable to implement the ANN to: receive data measured by the one or more sensors; and determine a classification of the data based on the network of interconnected nodes and the weights associated with the interconnects.
The disclosure relates to a device and method of obtaining an electrocardiogram for a subject. The method comprises receiving electrical signals from at least two head- mounted sensors; and analysing said electrical signals to resolve shape and timing information for each of the P-, Q-, R-, S-, and T-waves available for the subject over a number of cardiac cycles, to derive a composite electrocardiogram, ECG, in which the composite electrocardiogram is derived using signals only from said head-mounted sensors.
This invention relates to pyrrolopyrimidine comprising compounds that may be useful as inhibitors of Mitogen-activated Protein Kinase Kinase Kinase Kinase-4 (MAP4K4). The invention also relates to the use of these pyrrolopyrimidine comprising compounds, for example in a method of treatment. There are also provided processes for producing compounds of the present invention and method of their use. In particular, the present invention relates to compounds of formula (I).
CANCER RESEARCH TECHNOLOGY LIMITED (United Kingdom)
IMPERIAL INNOVATIONS LIMITED (United Kingdom)
Inventor
Bahl, Ash
Ainscow, Ed
Bondke, Alexander
Barrett, Anthony, G.M.
Sunose, Mihiro
Shiers, Jason John
Chohan, Kamaldeep
Abstract
inter aliain vitroin vivoin vivo, to inhibit CDK; and to treat disorders including: disorders that are associated with CDK; disorders that result from an inappropriate activity of a cyclin-dependent kinase (CDK); disorders that are associated with CDK mutation; disorders that are associated with CDK overexpression; disorders that are associated with upstream pathway activation of CDK; disorders that are ameliorated by the inhibition of CDK; proliferative disorders; cancer; viral infections (including HIV); neurodegenerative disorders (including Alzheimer's disease and Parkinson's disease); ischaemia; renal diseases; cardiovascular disorders (including atherosclerosis); and autoimmune disorders (including rheumatoid arthritis). Optionally, the treatment further comprises treatment (e.g., simultaneous or sequential treatment) with a further active agent which is, e.g., an aromatase inhibitor, an anti-estrogen, a Her2 blocker, a cytotoxic chemotherapeutic agent, etc.
The disclosure relates to a dielectrophoretic tweezer, and associated methods of fabrication and use. The tweezer comprises a first end and a second end, in which the first end has a lateral dimension of less than 10 microns; a structure, extending in a longitudinal direction between the first and second ends, comprising an electrically insulating barrier defining a first chamber and a second chamber within the structure, in which the first and second chambers are insulated from each other by the electrically insulating barrier; a first electrode in the first chamber at the first end; and a second electrode in the second chamber at the first end, in which a width of the electrically insulating barrier separating the first electrode from the second electrode is 50 nm or less..
The invention relates to biomarkers, and to novel biological markers for diagnosing various conditions, such as cancer. In particular, the invention relates to the use of these compounds as diagnostic and prognostic markers in assays for detecting cancer, such as pancreatic cancer and/or colorectal cancer, and corresponding methods of detection. The invention also relates to methods of determining the efficacy of treating these diseases with a therapeutic agent, and apparatus for carrying out the assays and methods. The assays are qualitative and/or quantitative, and are adaptable to large- scale screening and clinical trials.
There is provided a method of preparing a sheet metal material for forming, the method comprising preparing the sheet metal material to have a desired resistance profile along an axis; heating the sheet metal material to a desired temperature by passing a current along the axis; and cutting the sheet metal material to define a blank for forming into a predefined arrangement. There is also provided a method of forming a sheet material
A method for forming a component from a Ti-alloy or Ni-alloy sheet material. The method comprising heat treating the sheet material, wherein a final temperature of the sheet material is above 100°C below a β-transus temperature of the sheet material. The sheet material is formed into a predefined configuration between two dies. Forming is completed before the temperature of the sheet material reaches a start temperature for β to martensite transformation within the sheet material and wherein the temperature of the dies is less than a finish temperature for β to martensite transformation within the sheet material.
C22F 1/18 - High-melting or refractory metals or alloys based thereon
C22F 1/10 - Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of nickel or cobalt or alloys based thereon
B21D 22/02 - Stamping using rigid devices or tools
A method of forming a part from sheet metal and a part formed by said method are disclosed, the method comprising the steps of: (a) heating a metal sheet to a temperature T; and (b) forming the sheet into the part between dies whilst applying cooling means to the sheet, where in step a) the metal sheet is heated at a rate of at least 50 °C.s-1, and temperature T is above a critical forming temperature and does not exceed a critical microstructure change temperature of said metal sheet.
C22F 1/04 - Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of aluminium or alloys based thereon
C22F 1/06 - Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of magnesium or alloys based thereon
C22F 1/18 - High-melting or refractory metals or alloys based thereon
The invention provides an apparatus for fluidic exfoliation of a layered material comprising: a housing of circular cross-section defined by a housing wall; a hollow rotor of circular cross-section having a first end and a second end and a wall positioned therebetween arranged concentrically within the housing, wherein the wall of the hollow rotor defines an inner chamber and the space between the wall of the hollow rotor and the housing wall defines an outer chamber, and wherein a fluid flow path is provided between the inner chamber and the outer chamber; a fluid inlet in fluid communication with the inner chamber or the outer chamber; and a fluid outlet in fluid communication with the other of the inner chamber or the outer chamber; wherein the outer chamber has a width such that on passage of a fluid comprising the layered material from the inlet to the outlet through the outer chamber, a shear rate sufficient to exfoliate the layered material may be applied to the fluid comprising the layered material in the outer chamber by rotation of the hollow rotor.
The invention provides compositions and systems that allow the sensitive determination of the level of creatinine in a particular solution. Through the optimisation of enzymatic methods to detect creatinine the real-time determination of creatinine levels and creatinine clearance rates are also provided, allowing the real-time monitoring of kidney function. This is considered to be useful both in the monitoring of live subjects, and in the monitoring of isolated organs, such as a kidney, intended for transplantation.
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
C12Q 1/26 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving oxidoreductase
G01N 33/70 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving creatine or creatinine
C12Q 1/34 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase
32.
BUILDING, INTEGRATED DAMPING UNIT, AND METHOD OF DAMPING
A building that is susceptible to oscillation in response to an externally induced load, comprising a lateral load-resisting structure, a floor plate, and an interface between the lateral load resisting structure and the floor plate. The interface comprises fluid viscous dampers to dissipate energy, provide damping, and control acceleration of the floor plate. The floor plate acts as a damping mass that oscillates in opposition to oscillation of the lateral load resisting structure to dampen the oscillations of the building. The interface further comprises elastic elements, mounted in parallel to the fluid viscous dampers, to resist static load and control movement of the floor plate relative to the lateral load resisting structure. An integrated building damper unit, and a method of providing damping for a building, is also disclosed.
E04B 1/98 - Protection against other undesired influences or dangers against vibrations or shocksProtection against other undesired influences or dangers against mechanical destruction, e.g. by air-raids
E04H 9/02 - Buildings, groups of buildings or shelters adapted to withstand or provide protection against abnormal external influences, e.g. war-like action, earthquake or extreme climate withstanding earthquake or sinking of ground
E04H 9/14 - Buildings, groups of buildings or shelters adapted to withstand or provide protection against abnormal external influences, e.g. war-like action, earthquake or extreme climate against other dangerous influences, e.g. tornadoes, floods
F16F 15/16 - Suppression of vibrations in rotating systems by making use of members moving with the system using a fluid
Apparatus for achieving masing at room temperature, the apparatus comprising: a microwave cavity which exhibits a resonance of sufficiently high Q-factor for maser oscillation; a resonator structure comprising a masing medium located within a resonant element, wherein the masing medium comprises spin-defect centres, the resonator structure being disposed within the microwave cavity; means for applying a magnetic field across the masing medium; an input of microwave radiation to be amplified, the input of microwave radiation being coupled to the resonator structure; and means for optically pumping the masing medium and thereby causing stimulated emission of microwave photons; wherein the microwave cavity has an effective magnetic mode volume matching the volume of the masing medium. A corresponding method for producing masing at room temperature is also provided.
A lattice structure according to an embodiment of the invention comprises a plurality of struts integrally connected to one another at a plurality of nodes, wherein the plurality of struts are arranged into at least a first region comprising a first repeating strut arrangement, a second region comprising a second repeating strut arrangement, the first repeating strut arrangement being different to the second repeating strut arrangement, and a boundary region disposed between the first region and the second region, the boundary region comprising a plurality of struts configured to connect nodes in the first region to nodes in the second region, a strut arrangement in the boundary region being different to the first and second repeating strut arrangements. The first repeating strut arrangement and/or the second repeating strut arrangement may be configured based on a crystallographic lattice, including but not limited to the Bravais lattices. Such an arrangement of lattices can mimic the polygrain structure in crystals so as to enhance the strength and ductility of the lattice structure, using strengthening mechanisms analogous to those in crystalline alloys. Methods and apparatus for designing a lattice structure are also disclosed.
Example embodiments described herein are directed towards dynamic state estimation of an operating state of a generator in a power system. Such estimation is performed for an individual generator in real time with improved accuracy and without the use of Global Position System (GPS) synchronization.
An oxidant production apparatus comprises an electrochemical reactant reservoir, an electrolysis compartment, a porous first electrode and a second electrode. The porous first electrode defines a boundary between the reservoir and the electrolysis compartment and is configured to allow an electrochemical reactant to pass from the reservoir, through the first electrode and into the electrolysis compartment. The second electrode disposed at least substantially in the electrolysis compartment and spaced apart from the first electrode. The apparatus is configured to produce an oxidant in an electrochemical reaction when a voltage is applied across the first and second electrodes and a current is passed through the first and second electrodes and an electrolyte disposed in the electrolysis compartment.
Provided are a solder joint in which βSn grains are oriented in a specific desired direction, the βSn grains having a desired structure, and a bonding method relating to the solder joint. Provided is a solder joint in which at least two copper substrates (2) are bonded to each other using a lead-free solder alloy including Sn. A solder ball (1) relating to the lead-free solder alloy comprises: one or a plurality of nucleation grains (4); and a single grain βSn of which a [001] direction is parallel with a facet plane of the nucleation grains (4), and which is crystal-oriented in a specific direction with respect to the copper substrates (2).
B23K 1/20 - Preliminary treatment of work or areas to be soldered, e.g. in respect of a galvanic coating
B23K 35/26 - Selection of soldering or welding materials proper with the principal constituent melting at less than 400°C
H05K 3/34 - Assembling printed circuits with electric components, e.g. with resistor electrically connecting electric components or wires to printed circuits by soldering
Processes for the preparation of composite membranes are disclosed, as well as the composite membranes obtainable by these processes. The processes employ a step of roller coating a porous support substrate with an essentially solventless coating mixture containing a cationically UV curable compound, which can then be cured in an oxygen-containing atmosphere. The process thereby dispenses with–or greatly reduces the impact of–a number of the prominent processing constraints of prior art techniques, thereby affording a more streamlined and less energetically burdensome membrane manufacturing process.
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
The present disclosure provides a prosthesis for a through-knee amputee.The prosthesis comprises a proximal limb portion and a distal limb portion. The proximal limb portion comprise a socket which is configured to receive the upper leg of a through-knee amputee.The prosthesis also comprises at least two hinges to connect the proximal limb portion to the distal limb portion so that they can rotate about a single axis of rotation. The prosthesis also comprises a contact member and an engagement element. One of the contact member and engagement element is attached the proximal limb portion and the other of the contact member and engagement element is attached to the distal limb portion. One of both of the contact member and engagement element are biased towards the other. The contact member is adapted so that when the proximal limb portion and the distal limb portion undergo extension from a position of flexion, the contact member contacts the engagement element to displace the engagement element and/or contact member against the bias.
The invention provides n-type conjugated polymers of formula -[-M1-M2-]n-. Such polymers may be used as the active layer in organic electronic devices, such as < electrochemical transistors.
A method of extruding a material, comprising providing the material into an extrusion chamber of an extrusion apparatus, wherein the extrusion chamber comprises an extrusion orifice and the extrusion apparatus comprises a first compression element and a second compression element in communication with the interior of the extrusion chamber, the first and second compression elements being independently movable relative to the extrusion chamber, moving at least one of the first and second compression elements to compress the material within the extrusion chamber and cause a velocity gradient in the extrusion material across the extrusion orifice and extruding the material through the extrusion orifice such that the velocity gradient forms an extrudate with a curved profile.
B29C 47/00 - Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor (extrusion blow-moulding B29C 49/04)
The present invention relates to novel truncated fragments of von Willebrand factor (VWF) and the use of such fragments and nucleic acids encoding such fragments in the treatment of von Willebrand disease (VWD) and haemophilia.
A compound for an infrared light sensing device may be represented by a particular chemical formula and may be included in an infrared light sensing device. An image sensor may include the infrared light sensing device, and an electronic device may include the image sensor.
C07D 495/00 - Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
H01L 51/00 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof
H01L 27/30 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including components using organic materials as the active part, or using a combination of organic materials with other materials as the active part with components specially adapted for either the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation
H01L 51/42 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted either for the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation
H01L 51/05 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted for rectifying, amplifying, oscillating or switching and having at least one potential-jump barrier or surface barrier; Capacitors or resistors with at least one potential-jump barrier or surface barrier
44.
SYSTEMS AND METHODS FOR TREATING CARDIAC ARRHYTHMIA
Apparatus for monitoring activation in a heart comprises a probe (101), a plurality of electrodes (102) supported on the probe and extending over a detection area of the probe, the detection area being arranged to contact a detection region of the heart. Each of the electrodes (102) is arranged to detect electrical potential at a respective position in the heart during movement of a series of activation wave fronts across the detection region. A processor is arranged to analyse the detected electrical potentials to identify a propagation direction of at least one of the wave fronts, and to generate an output indicative of that direction.
The present invention provides phagemid vectors and associated phagemid particles for cancer treatment, and in particular, to the use of novel phagemid particles and associated expression systems for the treatment, prevention, amelioration, or management of cancer. In particular, the invention relates to the use of phagemid particles and expression systems for the delivery of transgenes encoding cytokines, for the treatment, prevention, amelioration, or management of cancer. The invention also extends to the use of phagemid particles and expression systems for the delivery of transgenes, and for the combination of such treatment with the use of adoptively transferred T cells, for the treatment, prevention, amelioration, or management of cancer.
A micromanipulation apparatus comprises an outer tube defining a longitudinal z-axis of the apparatus and an inner tube is at least partially disposed within the outer tube. The inner tube has a continuous working channel and an endoscopy probe extending therethrough. A steering mechanism controllably varies the lateral x, y position of a distal end of the inner tube, relative to the device z-axis, and an ablation energy delivery device extends through the apparatus along the z-axis. A contrast agent delivery mechanism delivers contrast agent to the distal end of the inner tube via the continuous working channel or via a lumen of the outer tube. An image processor analyses images from the endoscopy probe and a controller optically determines magnitudes of displacements of the distal end of the inner tube based on said analysed images which is used as feedback to the steering mechanism.
A61B 18/22 - Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibreHand-pieces therefor
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
The invention relates to a pneumococcal vaccine, to pharmaceutical compositions comprising said vaccine and to their uses in vaccination against pathogenic pneumococcal strains.
C07K 14/315 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
THE present application relates to a method of detecting one or more analytes in a sample, the method comprising (a) providing a carrier nucleic acid molecule with at least one single- stranded region; (b) providing one or more aptamers specific for the analyte, wherein the aptamers additionally comprise a single-stranded portion complementary to at least one single-stranded region on the carrier nucleic acid; (c) contacting the carrier nucleic acid and one or more aptamers with the sample, forming a carrier nucleic acid/aptamer/analyte complex, and; (d) detecting the presence of the carrier nucleic acid/aptamer/analyte complex.
The present disclosure relates generally to the assessment and treatment of vessels, including for percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG). For example, some embodiments of the present disclosure are suited for identifying the available intervention technique(s) suitable to achieve a desired outcome selected or input by a user. For example, in some implementations a method comprises receiving pressure measurements obtained by one or more intravascular pressure-sensing instruments positioned within a vessel of a patient; receiving an input from a user regarding a desired pressure value for the vessel of the patient; identifying an available treatment option based on the received pressure measurements and the desired pressure value; and outputting, to a display device, a screen display including a visual representation of the available treatment option. Related devices and systems are also described.
A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
A61B 5/0215 - Measuring pressure in heart or blood vessels by means inserted into the body
G16H 50/50 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
A61B 17/22 - Implements for squeezing-off ulcers or the like on inner organs of the bodyImplements for scraping-out cavities of body organs, e.g. bonesSurgical instruments, devices or methods for invasive removal or destruction of calculus using mechanical vibrationsSurgical instruments, devices or methods for removing obstructions in blood vessels, not otherwise provided for
G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 30/20 - ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
This invention relates to Natural Killer (NK) cell populations, to methods of producing the same and therapeutic applications thereof. More specifically, the invention relates to the expansion of NK cells by increasing the expression of specific transcription factors associated with NK cell production.
C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells
A61K 35/17 - LymphocytesB-cellsT-cellsNatural killer cellsInterferon-activated or cytokine-activated lymphocytes
C07K 14/435 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
A vehicle suspension system is disclosed. The suspension system comprises: a control arm (2) having a first end connectable to a wheel carrier and a second end connectable to an inboard component of the vehicle (5); a rotary actuator (6); and a linkage (17) connecting the rotary actuator to the control arm, so that torque applied to the linkage by the rotary actuator (6) is translated into a force which acts on the control arm (2).
B60G 17/015 - Resilient suspensions having means for adjusting the spring or vibration-damper characteristics, for regulating the distance between a supporting surface and a sprung part of vehicle or for locking suspension during use to meet varying vehicular or surface conditions, e.g. due to speed or load the regulating means comprising electric or electronic elements
A kinase or kinase fragment comprising a first label and a second label, wherein: the kinase or kinase fragment has a first conformation and second conformation; one or both of the first and second label are fluorophores; the first label and second label comprise an interacting pair capable of interacting with each other by static quenching or Dexter quenching or PET (photoinduced electron transfer) or exciplex formation to produce a quenched pair; and wherein the first and second labels are positioned on the kinase or kinase fragment such that when the kinase or kinase fragment is in the first conformation the labels are distal to each other such that static quenching or PET or Dexter quenching or exciplex formation does not occur and when the kinase or kinase fragment is in the second conformation the labels are brought into close proximity such that static quenching or PET or Dexter quenching or exciplex formation of one or both labels occurs.
A61K 31/00 - Medicinal preparations containing organic active ingredients
C12Q 1/48 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving transferase
A method for producing a porous boron nitride material. The method comprises providing a mixture comprising a first nitrogen-containing organic compound, a second nitrogen-containing organic compound and a boron-containing compound. The method further comprises heating the mixture to cause thermal degradation of the mixture and form a porous boron nitride material.
C01B 21/064 - Binary compounds of nitrogen with metals, with silicon, or with boron with boron
B01D 15/00 - Separating processes involving the treatment of liquids with solid sorbentsApparatus therefor
B01D 53/02 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography
The present invention is directed to a method for detecting the presence or absence of a bacterium resistant to a cyclic cationic polypeptide antibiotic, comprising: (a) subjecting a test sample to mass spectrometry analysis and generating a mass spectrum output; wherein said test sample comprises a bacterial membrane or a fragment thereof, wherein the fragment comprises a non- Lipid A component; (b) identifying in said mass spectrum output a first defined peak indicative of the presence of Lipid A modified by phosphoethanolamine, wherein said first defined peak is a peak present in a mass spectrum output for Lipid A modified by phosphoethanolamine and wherein said first defined peak is absent from a corresponding mass spectrum output for native Lipid A; and (c) wherein the presence of said first defined peak indicates the presence of a bacterium resistant to a cyclic cationic polypeptide antibiotic, and wherein the absence of said first defined peak indicates the absence of a bacterium resistant to a cyclic cationic polypeptide antibiotic. This method is also used in a screening method to identify an inhibitor of cyclic cationic polypeptide antibiotic resistance in a bacterium. The matrix solution can contain 2,5-dihydroxybenzoic acid and aids in the selective extraction, co-crystallisation and ionisation of native Lipid A and/or modified Lipid A as an integral part of a bacterial membrane.
C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms
C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
This invention relates to Natural Killer (NK) cell populations, to methods of producing the same and therapeutic applications thereof. More specifically, the invention relates to the expansion of NK cells by increasing the expression of specific transcription factors associated with NK cell production.
The present invention relates to a system and method useful for determining the voltage of biological tissues and therefore to detect whether such tissues are cancerous.
A composition for aiding the removal of polyps, in the form of a submucosal injectable formulation, comprising one or more salts of hyaluronic acid, saline solution and indigo carmine, but not including a substance exhibiting an angiotonic effect such as epinephrine, norepinephrine, or isoproterenol is described. Further described are a method for removing a polyp from a mucous membrane, the composition for use in endoscopic procedures and a kit for use in an endoscopic procedure.
A non-volatile memory cell comprising: a storage layer comprised of a ferromagnetic or ferroelectric material in which data is recordable as a direction of magnetic or electric polarisation; a piezomagnetic layer comprised of an antiperovskite piezomagnetic material selectively having a first type of effect on the storage layer and a second type of effect on the storage layer dependent upon the magnetic state and strain in the piezomagnetic layer; and a strain inducing layer for inducing a strain in the piezomagnetic layer thereby to switch from the first type of effect to the second type of effect.
G11C 11/16 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect
A coated fibre comprising a fibre and a coating, wherein the coating comprises nanoplatelets and a polymer, wherein the coating has a layered structure comprising at least two bilayers, each bilayer comprising a nanoplatelet layer and a polymer layer is described. A composite material comprising a plurality of coated fibres and a matrix is also described.
An ultrasonic imaging device is disclosed. The device comprises an ultrasonic transducer array (11) comprising a plurality of transducer elements (12), a multiplexer (15) comprising a plurality of inputs and at least one output, each input coupled to a respective transducer element, an analogue front-end (23) comprising at least one channel, each channel coupled to a respective output of the multiplexer and each channel including a respective analogue demodulator (44, 45) arranged to extract in- phase and quadrature components of a signal from the transducer and to provide demodulated in-phase and quadrature signal components (50, 51), at least two analogue-to-digital converters (60, 61) configured to receive signals comprising or obtained from the in-phase and quadrature signal components and to provide digitised demodulated in-phase and quadrature signal components and a wireless interface (32) configured to transmit signals comprising or obtained from the digitised demodulated in-phase and quadrature signal components.
Disclosed herein is a rectifier circuit for receiving an AC signal from a receiver coil in an inductive power transfer system. The circuit is configured to operate at an operating frequency. The circuit comprises a Class-E rectifier; an AC signal supplier configured to supply an AC signal to the rectifier circuit; and a resonant network having an inductor and a capacitor. The resonant network has a resonant frequency, and the ratio of the resonant frequency to the operating frequency is within the range of 1.75 to 3.
H02M 3/335 - Conversion of DC power input into DC power output with intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate AC using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only
H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
PRIMERS, METHODS AND KITS FOR DIAGNOSING AND PREDICTING THERAPY RESPONSE OF CANCERS BY COLD-PCR BASED AMPLIFICATION OF MUTATION-RICH REGIONS OF KRAS, EGFR AND P53
Nucleic acids primers for use in the detection of mutations in KRAS, EGFR and P53 associated with cancer, and in particular provides nucleic acids and methods employing reaction conditions suitable for use in COLD-PCR and high resolution melting HRM analysis of circulating tumour DNA, particularly from lung and colon cancers. The invention further relates to a combination of KRAS and APC mutations in diagnosing cancer.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
The disclosure concerns a WPT link optimization and discloses a method for designing low- complexity multisine waveforms for WPT. Assuming the CSI is available to the transmitter, the waveforms are expressed as a scaled matched filter and shown through realistic simulations to achieve performance very close to the optimal waveforms that would result from a non-convex posynomial maximization problem. Given the low complexity of the design, the proposed waveforms are very suitable for practical implementation.
H02J 50/20 - Circuit arrangements or systems for wireless supply or distribution of electric power using microwaves or radio frequency waves
H02J 50/23 - Circuit arrangements or systems for wireless supply or distribution of electric power using microwaves or radio frequency waves characterised by the type of transmitting antennas, e.g. directional array antennas or Yagi antennas
CANCER RESEARCH TECHNOLOGY LIMITED (United Kingdom)
Inventor
O'Flaherty, Linda
Tavaré, Jeremy Myles
Seckl, Michael Julian
Pardo, Olivier Emmanuel Rafi
Abstract
The present invention provides a GSK3 inhibitor for use in treating cancer, wherein the GSK3 inhibitor is to be administered in combination with a chemotherapy agent, methods of treatment comprising the same and methods for identifying cancers sensitive to such treatment.
A61K 31/4025 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
A61K 31/403 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
A61K 31/497 - Non-condensed pyrazines containing further heterocyclic rings
A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
A61K 31/5355 - Non-condensed oxazines containing further heterocyclic rings
A61K 31/551 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
A61K 33/00 - Medicinal preparations containing inorganic active ingredients
An implantable device for sensing intravascular pressure, the device comprising a bulk acoustic wave (BAW) resonator arranged to be deflected by changes in intravascular fluid pressure to provide a pressure dependent sensing signal and an acoustic reflector arranged to separate the BAW resonator from the intravascular fluid and to mediate pressure from the intravascular fluid to the BAW resonator wherein the acoustic reflector comprises a layer structure arranged to provide a series of transitions in acoustic impedance between the intravascular fluid and the BAW resonator.
A photovoltaic diode comprising an emitter layer of doped Group III- V semiconductor material, having a first conductivity type and a first bandgap in at least part of the layer, an intrinsic layer of dilute nitride Group III-V semiconductor material having a composition given by the formula Ga1-zInzNxAsySb1-x-y , where 0 < z < 0.20, 0.01 < x < 0.05, and y > 0.80 having a second bandgap, a base layer of semiconductor material having a third bandgap and a second conductivity type opposite to the first conductivity type. The emitter, intrinsic and base layers form a diode junction. The first bandgap is greater than the second bandgap.
The invention provides nanocages, and in particular to protein nanocages, and especially ferritin nanocages. The invention extends to variant ferritin polypeptides and their encoding nucleic acids, mutant ferritin nanocages, and their uses in diagnostics and drug delivery, as well as in phenotypic screens in drug development.
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (France)
Inventor
Antonakakis, Tryfon
Craster, Richard
Achaoui, Younes
Enoch, Stefan
Guenneau, Sebastien
Brule, Stephane
Abstract
A seismic wave shield for protecting an area from seismic vibrations and a method of shielding an area from seismic waves by installing a seismic wave shield. The seismic wave shield comprises a set of columns (1) embedded in regolith (3) and in contact with bedrock (4). There is a material contrast between a material forming the columns (1) and the regolith (3).
E02D 27/34 - Foundations for sinking or earthquake territories
E04H 9/02 - Buildings, groups of buildings or shelters adapted to withstand or provide protection against abnormal external influences, e.g. war-like action, earthquake or extreme climate withstanding earthquake or sinking of ground
G01V 1/00 - SeismologySeismic or acoustic prospecting or detecting
A surgical fastener having a first part and a second part, each of the first and second parts comprising a clamping bar and a centrally-positioned perpendicular bracing bar extending therefrom, the clamping bar and bracing bar together defining a "T"- shape, wherein the surgical fastener further comprises at least one bracing element connecting the bracing bar of each of the first and second parts. A surgical apparatus for the application of a fastener to tissue comprising a handle assembly, a shaft extending distally from the handle assembly, a drive assembly, an articulation assembly and a jaw assembly mounted adjacent a distal end of the shaft comprising fixed support jaw and a clamping jaw, at least one of the jaws comprises a rotatable fastener support defining a T-shaped recess therein for receiving a surgical fastener, wherein the articulation assembly is operable to rotate the fastener support and the drive assembly is operable by the handle assembly to move the clamping jaw in and out of a closed configuration with respect to the support jaw.
A61B 17/122 - Clamps or clips, e.g. for the umbilical cord
A61B 17/128 - Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord for applying or removing clamps or clips
A61F 5/00 - Orthopaedic methods or devices for non-surgical treatment of bones or jointsNursing devices
The present invention provides a load sensing device for a surgical robot comprising a load sensing means and a hook mounted to the load sensing means, wherein the coupling is slideable longitudinally and engageable with a tendon for actuating a surgical instrument such that longitudinal movement of the hook imparts a load on the tendon and the load sensing means measures such load.
A61B 34/00 - Computer-aided surgeryManipulators or robots specially adapted for use in surgery
B25J 13/08 - Controls for manipulators by means of sensing devices, e.g. viewing or touching devices
A61B 17/00 - Surgical instruments, devices or methods
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
71.
METHOD OF CREATING A COMPONENT USING ADDITIVE MANUFACTURING
There is provided a method of manufacturing a component. The method comprises creating a preform from a material using additive manufacturing and heat treating the preform at a heating temperature to modify the microstructure of the material. The preform is geometrically unconstrained during the step of heat treating. The method then comprises compressive forming the preform into a predefined arrangement to create the component wherein the step of compressive forming is effective to close pores and diffusively bond the material. The material may then be geometrically constrained as it is cooled, for example within the die used for compressive forming.
B21J 5/00 - Methods for forging, hammering, or pressingSpecial equipment or accessories therefor
B22F 3/105 - Sintering only by using electric current, laser radiation or plasma
B22F 5/10 - Manufacture of workpieces or articles from metallic powder characterised by the special shape of the product of articles with cavities or holes, not otherwise provided for in the preceding subgroups
A surgical implant (100) comprising a body having proximal and distal ends and a longitudinal axis extending therebetween, the body comprising a core (105) and at least one end portion (115) at the distal end and a plurality of discrete whiskers (110) extending outwardly from the core (105) and at an acute angle relative to a longitudinal axis of the body in a proximal direction. The surgical implant preferentially allows direction in one direction and provides superior implant stability post-surgery due to the mechanical interaction between the whiskers and the bone structure providing increased resistance to pull-out of the implant.
A molecular complex comprising a therapeutic agent and a controlled release construct, the controlled release construct comprising a primary matrix conjugation site which is linked to an cell adhesive site, via a binding region and optionally via one or more spacer elements, wherein the binding region has a folded configuration in which it is bound to the therapeutic agent, wherein the construct is configured such that when mechanical tension is applied between the primary matrix conjugation site and the cell adhesive site, the binding region adopts a less folded configuration in which bound therapeutic agent is released. Related controlled release constructs for loading with the therapeutic agent, pharmaceutical compositions and methods of manufacture and use.
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61K 47/51 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
A61K 47/42 - ProteinsPolypeptidesDegradation products thereofDerivatives thereof, e.g. albumin, gelatin or zein
A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
An implantable intravascular pressure sensor comprising a first transducer arranged to provide a pressure dependent signal in response to alternating electrical signals of a first frequency band, a second transducer arranged to provide a reference signal in response to alternating electrical signals of a second frequency band different from the first frequency band and an antenna coupling for sending and receiving said signals.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61B 5/0215 - Measuring pressure in heart or blood vessels by means inserted into the body
A61B 5/03 - Measuring fluid pressure within the body other than blood pressure, e.g. cerebral pressure
G01L 9/00 - Measuring steady or quasi-steady pressure of a fluid or a fluent solid material by electric or magnetic pressure-sensitive elementsTransmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means
An implantable intravascular device for deployment inside a human or animal, the apparatus comprising a body of crystalline material and a membrane of crystalline material fixed to the body by a hermetic bond an assembly of components carried on said crystalline material and arranged for responding to electrical signals wherein the body and the membrane at least partially encapsulate the assembly.
An implantable intravascular anchor for supporting a device inside a vascular lumen, the anchor comprising a first part configured to expand when extending from a catheter, and to collapse upon retraction into said catheter; a second part for supporting the device in the lumen and a third part, proximal to the first part, and configured so that, upon release from the catheter, it expands in width to engage an interior wall of the lumen and is adapted for securing the anchor against axial movement along the lumen.
A61F 2/89 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
Composite materials are described, as well as their processes of preparation, and their specific uses. The composite materials comprise a 2-dimensional carbon thin film and at least one further material, where the 2-dimensional carbon thin films are fabricated by preparing an organic polymeric thin film precursor, which is then subjected to a carbonisation process to remove at least some of the non-carbon atoms. Using the disclosed process, composite materials having improved dimensional characteristics can be reliably prepared, which presents clear advantages in applications which have until now been restricted to the use of 2- dimensional carbon thin films having less useful dimensions.
An implantable device for deployment inside a human or animal body, the device comprising at least one sensing component arranged to respond to an electrical signal having a known frequency band and at least one antenna comprising at least one antenna pole connected to the at least one sensing component, the antenna pole comprising at least one helical coil and a connecting stem.
Apparatus (10) for establishing quantum oscillations at room temperature, the apparatus comprising: a cavity having a resonator structure therein, the resonator structure comprising a resonant element (18) and a gain medium (16), a species of the gain medium having an electronic spin multiplicity capable of supporting a two-level spin system; and optical pumping means (24) arranged to pump the resonator structure and thereby generate microwave output power through stimulated emission of thermal photons; wherein said species of the gain medium is of a sufficiently high concentration such as to have an ensemble spin-photon coupling rate which exceeds both the cavity mode decay rate and the spin-spin decoherence rate; and wherein the optical pumping means is configured to pump the resonator structure using a short pulse of nanosecond duration, or a burst of approximately a millisecond in duration at relatively low instantaneous optical power, to excite said species of the gain medium into a spin-polarized two-level system that exhibits quantum oscillations in the microwave output power. The outer casing (12) may be made from copper and has an inlet (20) for the pump beam (22) and an outlet (28) allowing coupling of the radiation into a transmission line (26).The resonance frequency of the resonator may be controlled with an adjustable top wall (13). A corresponding method for establishing quantum oscillations at room temperature is also provided.
A method of analysing a structure of a composition of matter in a sample comprising obtaining a data set comprising a plurality of spectra from the composition, from a first method of analysis dividing each of the spectra into a plurality of bins determining a control parameter or parameters indicative of synchronised fluctuations in signal intensity across some or all channels, resulting in universal correlation between said bins determining a partial covariance of different bins across the plurality of spectra using the control parameter to correct the correlation of intensity fluctuations between said bins.
G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
There is provided a system and method for guiding a flow of fluid having a variable mass flow rate onto a turbine (110), the turbine comprising a blade (115) and configured to rotate about an axis of rotation (150), the method using a flow-guidance element (120) in fluid communication with the turbine, the flow-guidance element comprising a flow-guiding vane (125), wherein a trailing edge of the flow-guiding vane is arranged at an angle of β 4 relative to a reference line extending perpendicular from the axis of rotation to the trailing edge of the flow-guiding vane and wherein the angle β 4 is less than or equal to 80 degrees, the flow-guidance element configured to guide a flow of fluid onto the turbine at a relative fluid flow angle to rotate the turbine about the axis of rotation. The method comprises rotating the flow-guidance element about the same axis of rotation as the turbine so as to alter a variation of the relative fluid flow angle at turbine ingress arising from a varying mass flow rate of the flow of fluid.
A method of adaptively determining one or more compensation factors in a closed-loop insulin delivery system comprising a continuous glucose level sensor, an insulin pump, and an insulin reservoir, where the system determines an insulin meal bolus taking into account an estimated amount of carbohydrates to be ingested, CHO, a difference between a currently sensed glucose level, G, and a glucose set point, Gsp, and at least one compensation factor, ICR. The method comprises for each postprandial time period, t3-t4, determining a bolus offset value, Bextra_new, by, if the sensed glucose level, G, exceeds a threshold level, Gl, determining a total insulin amount delivered by the insulin pump over the postprandial time period and setting the bolus offset value, Bextra_new, to that total insulin amount, or if the sensed glucose level, G, is less than the threshold level, Gl, determining an offset between the sensed glucose level, G, and the glucose set point, Gsp, and using that offset to determine the bolus offset value, Bextra_new, adapting the compensation factor, ICR, over time using the determined the bolus offset value, Bextra_new, in order to minimize the bolus offset value for subsequent postprandial time periods.
G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
83.
METHODS, SYSTEMS AND APPARATUS FOR IDENTIFYING PATHOGENIC GENE VARIANTS
A system for assessing the pathogenicity of a genetic variant, comprises a data analysis server connected to at least one of a genetic information data source storing frequency information relating to frequency of at least one genetic variant in at least a control population, a disease-variation association data source storing information on associations between at least one gene variant, at least one gene or other gene variants in the at least one gene with diseases; and a protein-related data source storing information on the known or predicted effects of at least one genetic variant on a gene product. The data analysis server is connected to a user device and is configured to receive information from a user about a genetic variant identified in an individual, and to determine and transmit a pathogenicity score to the user device.A method of assessing pathogenicity of a genetic variant, a data analysis server and a computing device are also disclosed.
G06F 19/18 - for functional genomics or proteomics, e.g. genotype-phenotype associations, linkage disequilibrium, population genetics, binding site identification, mutagenesis, genotyping or genome annotation, protein-protein interactions or protein-nucleic acid interactions
G06F 19/00 - Digital computing or data processing equipment or methods, specially adapted for specific applications (specially adapted for specific functions G06F 17/00;data processing systems or methods specially adapted for administrative, commercial, financial, managerial, supervisory or forecasting purposes G06Q;healthcare informatics G16H)
84.
METHOD OF DETECTING ACTIVE TUBERCULOSIS USING MINIMAL GENE SIGNATURE
A method of detecting active TB in the presence of a complicating factor, for example, latent TB and/or co-morbidities, such as those that present similar symptoms to TB. The disclosure also relates to a minimal gene signature employed in the said method and to a bespoke gene chip for use in the method. The disclosure further relates to use of gene chips and primer sets in the methods of the disclosure and kits comprising the elements required for performing the method. The disclosure also relates to use of the method to provide a composite expression score which can be used in the diagnosis of TB, particularly in a low resource setting.
The present invention relates to a method of measuring the rate of reaction between a target molecule and a ligand candidate, ligands of interest identified according to this method and drugs developed from such ligands. The present invention also relates to a method of measuring the rate of reaction between a thiol and a molecule capable of reacting with said thiol.
G01N 33/557 - ImmunoassayBiospecific binding assayMaterials therefor using kinetic measurement, i.e. time rate of progress of an antigen-antibody interaction
86.
METHOD OF IDENTIFYING A SUBJECT HAVING A BACTERIAL INFECTION
A method of identifying a subject having a bacterial infection, which includes discriminating said subject from a subject having a viral infection or an inflammatory disease. Also provided is a gene signature employed in the method and to a bespoke gene chip for use in the method. Further provided are probes and/or primers specific to genes in a signature of the present disclosure.
The present technique provides an apparatus comprising receiver circuitry to receive a signal formed from a plurality of multipath signal components, including a first set of multipath signal components that have been subjected to modulation by interaction with at least one moving part of a target machine. The first set of multipath signal components have time varying signal paths due to the interaction with said at least one moving part. Evaluation circuitry is used to generate, for at least one property of the received signal, an evaluation signal, and modification circuitry then produces a modified evaluation signal by applying a removal operation to at least partially remove from said evaluation signal a contribution to that evaluation signal from the multipath signal components whose associated signal paths are non-time-varying. Thereafter processing circuitry performs one or more processing operations on the modified evaluation signal to produce a motional signature indicative of the motion of said at least one moving part.
G01M 5/00 - Investigating the elasticity of structures, e.g. deflection of bridges or aircraft wings
G01B 17/04 - Measuring arrangements characterised by the use of infrasonic, sonic, or ultrasonic vibrations for measuring the deformation in a solid, e.g. by vibrating string
This invention relates to aqueous ink compositions comprising an aqueous solvent, particles comprising a metal or a metal compound or a mixture thereof, a dispersant, preferably selected from an electrostatic dispersant, a steric dispersant, an ionic dispersant, a non-ionic dispersant or a combination thereof, a polymeric binder and a non-ionic surfactant which may be used for 3D inkjet printing components, primarily for high- temperature electrochemical devices..
H01M 8/1253 - Fuel cells with solid electrolytes operating at high temperature, e.g. with stabilised ZrO2 electrolyte characterised by the process of manufacturing or by the material of the electrolyte the electrolyte consisting of oxides the electrolyte containing zirconium oxide
H01M 8/126 - Fuel cells with solid electrolytes operating at high temperature, e.g. with stabilised ZrO2 electrolyte characterised by the process of manufacturing or by the material of the electrolyte the electrolyte consisting of oxides the electrolyte containing cerium oxide
H01M 8/124 - Fuel cells with solid electrolytes operating at high temperature, e.g. with stabilised ZrO2 electrolyte characterised by the process of manufacturing or by the material of the electrolyte
An anatomical joint comprising a base and an end effector, wherein the end effector is movable relative to the base by way of a ball joint defined at least in part by a ball and socket, wherein the socket comprises a sidewall having at least one cut out therein such that less than 70% of the ball is encapsulated within the socket in the region of the at least one cut out
B25J 19/00 - Accessories fitted to manipulators, e.g. for monitoring, for viewingSafety devices combined with or specially adapted for use in connection with manipulators
90.
ACOUSTIC SUB-APERTURE PROCESSING FOR ULTRASOUND IMAGING
A method for ultrasound data processing comprises transmitting an ultrasound excitation signal from each element of a transducer array and receiving a response signal from each element of a transducer array. Each response signal corresponds to a respective channel. Each response signal is sampled at one or more time points in the response signal to create a plurality of samples, each sample corresponding to a channel and a time point. The samples are divided into at least two groups. Response signals from the first group are beamformed and response signals from the second group are beamformed separately. The process is repeated over multiple data frames. The beamformed signals of each group are correlated over the multiple data frames and beamformed signals having a lower degree of correlation or negative correlation are selectively attenuated. An image output is generated from the correlation output. The at least two groups of channels may be selected to minimise the similarity of noise and/or the received acoustic field outside the main lobe.
The present invention relates to a process for preparing an asymmetric integrally skinned membrane for the separation of at least one solute from a solution, comprising the steps of: (a) preparing a polybenzimidazole dope solution comprising: (i) a polybenzimidazole polymer, and (ii) a solvent system for said polybenzimidazole which is water miscible; (b) casting a film of said dope solution onto a support; (c) immersing the film cast on the support into a coagulating medium to form an asymmetric integrally skinned membrane; (d) treating the membrane from step (c) with a cross-linking agent; (e) treating the membrane from step (d) with a cross-link modification agent. Further aspects relate to an asymmetric integrally skinned membrane and uses thereof.
B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
B01D 71/62 - Polycondensates having nitrogen-containing heterocyclic rings in the main chain
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
92.
NEUTRALISING ANTIBODY AGAINST DENGUE FOR USE IN A METHOD OF PREVENTION AND/OR TREATMENT OF ZIKA INFECTION
A flavivirus Envelope Dimer Epitope (EDE) for use in vaccinating an individual against one or more flaviviruses wherein the EDE is a stabilized recombinant flavivirus, optionally dengue virus and/or zika envelope glycoprotein E ectodomain (sE) dimer, wherein the dimer is: covalently stabilized with at least one disulphide inter-chain bond between the two sE monomers, and/or non-covalently stabilized by substituting at least one amino acid residue in the amino acid sequence of at least one sE monomer with at least one bulky side chain amino acid, at the dimer interface or in domain 1 (D1) / domain 3 (D3) linker of each monomer, covalently stabilized with at least one sulfhydryl-reactive crosslinker between the two sE monomers, and/or covalently stabilised by being formed as a single polypeptide chain, optionally with a linker region, optionally a Glycine Serine rich linker region, separating the sE sequences, and/or covalently stabilized by linking the two sE monomers through modified sugars; and/or, wherein the dimer is a homodimer or heterodimer of native and/or mutant envelope polypeptides, from any one or two of DENV-1, DENV-2, DENV-3, DENV-4, Zika or other flavivirus; and wherein the one or more flaviviruses is selected from zika virus; zika virus and dengue virus; zika virus and other flaviviruses; flaviviruses other than dengue. The EDE may be a homodimer or heterodimer of native and/or mutant envelope polypeptides, from any one or two of DENV-1, DENV-2, DENV-3, DENV-4 and Zika. An isolated neutralizing antibody or antigen binding fragment thereof directed against the EDE as defined in any one of claims 1 to 29, optionally wherein said antibody or fragment thereof binds the five polypeptide segments of the dengue virus glycoprotein E ectodomain (sE) consisting of the residues 67-74, residues 97-106, residues 307-314, residues 148-159 and residues 243-251, or corresponding residues of the flavivirus or Zika virus glycoprotein E ectodomain, or consisting of Zika PF13 residues 67-77, residues 97-106, residues 313-315, residues 243-253, residue K373 or corresponding residues of the flavivirus glycoprotein E ectodomain, optionally wherein binding is unaffected by presence or absence of dengue N153 (Zika N154) glycan or corresponding residue, for use in a method for prevention and/or treatment of infection by one or more flaviviruses, wherein the one or more flaviviruses is selected from zika virus; zika virus and dengue virus; zika virus and other flaviviruses; flaviviruses other than dengue.
An electrically conductive composite coating comprises a layer of an electrically conductive coating material (101) comprising a carbon-based material and an azole corrosion inhibitor; and a layer of tin or a tin alloy (102), such as tin-antimony (Sn-6wt%Sb) alloy. The coating material may include an organic binder. The coating may be used to protect a component (100) in an electrochemical device such as a fuel cell assembly, a battery, a redox flow battery, an electrolyser or a supercapacitor. The coating shows no significant sign of corrosion after 9 days in accelerated long term corrosion tests in an aggressive environment.
The present invention relates to a method of reducing, cleaving and/or coupling at least one C=O, C-O, C=C or C=N bond of a compound, using a reagent comprising a stannyl cation.
C07C 29/145 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen-containing functional group of C=O containing groups, e.g. —COOH of ketones with hydrogen or hydrogen-containing gases
C07C 29/153 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of oxides of carbon exclusively with hydrogen or hydrogen-containing gases characterised by the catalyst used
C07C 67/303 - Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by hydrogenation of unsaturated carbon-to-carbon bonds
C07C 68/04 - Preparation of esters of carbonic or haloformic acids from carbon dioxide or inorganic carbonates
C07C 303/40 - Preparation of esters or amides of sulfuric acidsPreparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
C07C 209/26 - Preparation of compounds containing amino groups bound to a carbon skeleton by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds by reduction with hydrogen
C07C 209/52 - Preparation of compounds containing amino groups bound to a carbon skeleton by reduction of carboxylic acids or esters thereof in presence of ammonia or amines, or by reduction of nitriles, carboxylic acid amides, imines or imino-ethers by reduction of imines or imino-ethers
C07D 295/033 - Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
C07C 27/06 - Processes involving the simultaneous production of more than one class of oxygen-containing compounds by reduction of oxygen-containing compounds by hydrogenation of oxides of carbon
C07C 211/27 - Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
C07C 211/29 - Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
C07C 311/16 - Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
C07C 211/35 - Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of a saturated carbon skeleton containing only non-condensed rings
C07C 31/10 - Monohydroxylic acyclic alcohols containing three carbon atoms
C07C 69/06 - Formic acid esters of monohydroxylic compounds
C07C 33/20 - Monohydroxylic alcohols containing only six-membered aromatic rings as cyclic part monocyclic
C07C 31/12 - Monohydroxylic acyclic alcohols containing four carbon atoms
C07C 31/125 - Monohydroxylic acyclic alcohols containing five to twenty-two carbon atoms
C07C 69/24 - Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with monohydroxylic compounds
95.
Liposome nanoparticles for tumor magnetic resonance imaging
UNITED KINGDOM RESEARCH AND INNOVATION (United Kingdom)
IMPERIAL INNOVATIONS LIMITED (United Kingdom)
Inventor
Kamaly, Nazila
Kalber, Tammy Louise
Kenny, Gavin David
Thanou, Maya
Miller, Andrew David
Bell, Jimmy David
Abstract
The present invention provides novel liposomes comprising Gd.DOTA.DSA (gadolinium (III) 2-{4,7-bis-carboxymethyl-10-[(N,N-distearylamidomethyl-N′-amido-methyl]-1,4,7,10- =tetra-azacyclododec-1-yl}-acetic acid), characterised in that the liposome further comprises a neutral, fully saturated phospholipid component (e.g. DSPC (1,2-distearoyl-sn-glycero-3-phospocholine]), which are of particular use in the preparation of magnetic resonance contrast agents for enhancing a magnetic resonance image of tumours in a mammal.
A61K 49/18 - Nuclear magnetic resonance [NMR] contrast preparationsMagnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
96.
MULTI-JUNCTION SOLAR CELL, ITS FABRICATION AND ITS USE
There is provided a multi-junction solar cell comprising: a target subcell,a diffraction grating,a transparent spacer layer, a distributed Bragg reflector, and a lower subcell.
H01L 31/055 - Optical elements directly associated or integrated with the PV cell, e.g. light-reflecting means or light-concentrating means where light is absorbed and re-emitted at a different wavelength by the optical element directly associated or integrated with the PV cell, e.g. by using luminescent material, fluorescent concentrators or up-conversion arrangements
H01L 31/0687 - Multiple junction or tandem solar cells
H01L 31/0725 - Multiple junction or tandem solar cells
H01L 31/056 - Optical elements directly associated or integrated with the PV cell, e.g. light-reflecting means or light-concentrating means the light-reflecting means being of the back surface reflector [BSR] type
H01L 31/054 - Optical elements directly associated or integrated with the PV cell, e.g. light-reflecting means or light-concentrating means
97.
SURGICAL INSTRUMENT, ROBOTIC ARM AND CONTROL SYSTEM FOR A ROBOTIC ARM
A surgical instrument comprising: a rigid shaft, at least one elbow joint hingedly coupled to the rigid shaft and a wrist joint coupled to the at least one elbow joint, wherein the wrist joint is configured to provide a first degree of freedom of movement and a second degree of freedom of movement, wherein the second degree of freedom of movement is substantially perpendicular to the first degree of freedom of movement.
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 90/50 - Supports for surgical instruments, e.g. articulated arms
Apparatus for locating an attachment position for a reconstructed anterior cruciate ligament on an attachment surface of a bone comprises locating means 51, 61 arranged to locate at least one reference surface 4 of the bone and guide means 53, 54 arranged to define the attachment position in two dimensions on the attachment surface relative to the reference surface.
A61F 2/46 - Special tools for implanting artificial joints
A61B 17/16 - Instruments for performing osteoclasisDrills or chisels for bonesTrepans
A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
A61B 34/10 - Computer-aided planning, simulation or modelling of surgical operations
UNIVERSITY OF NEWCASTLE UPON TYNE (United Kingdom)
Inventor
Constandinou, Timothy
Jackson, Andrew
Abstract
A neural interface arrangement comprising: a plurality of probes for subdural implantation into or onto a human brain, each probe including at least one sensing electrode, a coil for receiving power via inductive coupling, signal processing circuitry coupled to the sensing electrode(s), and means for wirelessly transmitting data-carrying signals arising from the sensing electrode(s); an array of coils for implantation above the dura, beneath the skull, the array of coils being for inductively coupling with the coil of each of the plurality of probes, for transmitting power to the probes; and a primary (e.g. subcutaneous) coil connected to the array of coils, the primary coil being for inductively coupling with an external transmitter device, for receiving power from the external transmitter device; wherein, in use, the primary coil is operable to receive power from the external transmitter device by inductive coupling and to cause the array of coils to transmit power to the plurality of probes by inductive coupling; and wherein, in use, the plurality of probes are operable to wirelessly transmit data-carrying signals arising from the sensing electrodes.
A load-independent Class EF inverter may maintain ZVS operation, and produce a constant output current, rather than a constant output voltage, regardless of the load resistance. A constant output current allows the inverter to operate efficiently for a load range from zero resistance (short circuit) to a certain maximum load resistance, making the inverter more suitable as a coil driver for an IPT system. The resonant frequency of the resonant circuit may be tuned to a non-integer multiple of a switching frequency.
H02J 50/12 - Circuit arrangements or systems for wireless supply or distribution of electric power using inductive coupling of the resonant type
H02J 7/02 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries for charging batteries from AC mains by converters
H02M 7/537 - Conversion of DC power input into AC power output without possibility of reversal by static converters using discharge tubes with control electrode or semiconductor devices with control electrode using devices of a triode or transistor type requiring continuous application of a control signal using semiconductor devices only, e.g. single switched pulse inverters
