Systems and methods for suppressing a patient cardiac inflammation condition with cardiac contractility modulation stimulation therapy, the system comprising a implantable controller, the controller configured to carry out the method of: a. receiving at least one parameter indicative of an increase and/or a change in an inflammatory state in said patient; and b. providing cardiac contractility modulation stimulation therapy and suppressing a patient cardiac inflammation condition.
A cardiac treatment device, including:
stimulation circuitry configured to generate a non-excitatory electrical signal which, when applied to ventricular tissue during a ventricular refractory period thereof improves a condition of heart failure in human patients;
atrial arrhythmia detection circuitry; and
decision circuitry which controls the stimulation circuitry to delivery said signal, also when said atrial arrhythmia detection circuitry detects an atrial arrhythmia.
A method of managing security of an implanted device including estimating a risk to, or a need of, a user in who the device is implanted; and automatically applying, by the device, a security level regarding communication to the device and/or actions by the device according, to said estimation. In some mebdoimnts, the need is a medical need, such as an emergency situation. In some mebdoimnts the risk is assessed base don a location of the implanted device.
During a cardiac arrhythmia, defibrillation shocks from an implanted cardiac defibrillator are suppressed based on the sensing of electrical wavefront arrival times which indicate a supraventricular origin to the cardiac arrhythmia. In some embodiments, times of electrical wavefront arrival in at least two ventricular locations of the heart are sensed; one location being relatively superior, and one relatively inferior (e.g., relatively superior and inferior locations of a ventricular septum). In some embodiments, if the arrival time at the more inferior position is within a predetermined interval after arrival at the more superior position, delivery of defibrillation shocks are suppressed. In some embodiments, additional sensing of electrical wavefront arrival at one or more non-septal ventricular locations is performed, and defibrillation shock suppression is optionally itself suppressed if the additional sensing indicates that the wavefront initiated in a ventricular location.
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
5.
MEANS AND METHODS FOR USING NON-EXCITATORY ELECTRICAL HEART FAILURE THERAPY AS A THERAPY FOR HEART FAILURE WITH PRESERVED EJECTION FRACTION
A system for cardiac electrical stimulation treatment, comprising: an implantable pulse generator; one or more leads extending from the pulse generator to the heart for applying cardiac electrical stimulation; a controller programmed with at least one treatment plan for applying cardiac electrical stimulations, the controller configured to automatically update the treatment plan in response to actual cardiac activity by updating one or more parameters including: a time period during which cardiac electrical stimulations are applied; a rate of cardiac electrical stimulations; an amount of energy delivered at each cardiac electrical stimulation.
Embodiments of communication systems are disclosed for protecting communication between an implanted device ID and an external device ED. Optionally, the ID communicates over the TET channel by modulating a load on the channel. While the ID is communicating the ED optionally adds noise to the TET channel, inhibiting malicious interception of the communication. Using knowledge of the noise signal, the ED cleans the noise from the TET signal to recover the communication from the ID. In some embodiments, the TET link is used to pass an encryption key and/or to verify communications over a radio channel. The TET channel may be authenticated. For example, authentication may include a minimum energy and/or power transfer.
H04B 5/72 - Near-field transmission systems, e.g. inductive or capacitive transmission systems specially adapted for specific purposes for local intradevice communication
H04W 12/03 - Protecting confidentiality, e.g. by encryption
H04W 12/0431 - Key distribution or pre-distributionKey agreement
An aspect of some embodiments of the invention relates to providing acute non-excitatory electrical heart failure therapy to a patient according to one or more criteria. Exemplary criteria are one or more of suffering from an acute angina episode, a patient after a myocardial infraction episode, a patient after heart surgery, a patient that is already on a Cath-Lab and would be beneficial to see if the treatment could help the patient, patients that suffer from heart failure and optionally already receive chronic non-excitatory electrical heart failure therapy, a patient that requires an improvement in blood flow, patients that show positive results from trial activation of acute non-excitatory electrical heart failure therapy, patients that require assistance in performing daily activities, like exercise, social events, after taking certain drugs, performing intercourse, sleeping and suffer from emotional stress.
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
A method for detecting lead failure in an implantable device using a multiple signal input configuration, including receiving a first signal from a first lead, receiving a second signal from a second lead, comparing the first signal and the second signal, and if the first signal is different from the second signal, determining whether one of the first lead and the second lead is faulty. Related apparatus and methods are also described.
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
An implantable cardiac device comprises a device can and a single lead extending from the device can for cardiac emplacement. The lead senses a first cardiac wave propagating along a first vector and the same cardiac wave propagating along a second vector. The first vector may be between first and second locations on the lead, and the second vector between the lead and the device can or involving other locations on the lead so that a second lead is not needed and it is possible to make a single lead device.
An implantable device containing a plurality of batteries, the plurality of batteries including at least one first non-rechargeable battery, and at least one second rechargeable battery. A method for providing power for a Cardiac Contractility Modulation Implantable Cardioverter Defibrillator (ICD) device, the method including providing power for cardioversion or defibrillation operation by a first, non-rechargeable battery, and providing power for Cardiac Contractility Modulation operation by a second, rechargeable battery. A method for controlling power for an implantable device having a rechargeable battery, a non-rechargeable battery and a Cardioverter Defibrillator module, the method including measuring electric power level of the rechargeable battery, comparing the rechargeable battery level to a threshold, if the electric power level of the rechargeable battery is less than the threshold, then providing power for the device from the non-rechargeable battery. Related apparatus and methods are also described.
Methods and devices for tying management of an implantable medical device to the activities of a primary care physician are described, including access control, simplified parameter optimization, support for tuning a device in response to the effects of other treatments in parallel, and support for helping a primary physician and a patient work together to tune device configuration to the activity and performance needs of the patient. In some embodiments, a medical device is self-configuring in a device parameter domain, based on inputs provided in a patient performance domain. The self-configuring of the medical device is based, for example, on an automatically applied transformation of inputs derived from patient performance domain observations into changes in the configuration of the medical device which affect technical parameters of its operation.
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
A61M 60/148 - Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient’s body implantable via, into, inside, in line, branching on, or around a blood vessel in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
A61M 60/178 - Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient’s body implantable in, on, or around the heart drawing blood from a ventricle and returning the blood to the arterial system via a cannula external to the ventricle, e.g. left or right ventricular assist devices
A61M 60/508 - Electronic control means, e.g. for feedback regulation
G05B 15/02 - Systems controlled by a computer electric
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
The present invention discloses means and methods for performing evaluation of an electrocardiogram (ECG) morphology in an implantable device, optionally the implantable device has a single ECG sensing lead.
A method of anti-tachycardia pacing via an implanted cardiac device, comprising: positioning at least one electrode of the implanted cardiac device at an intra-cardiac location; detecting a tachycardia episode; delivering, via the at least one electrode, anti-tachycardia pacing pulses, wherein an anti-tachycardia pacing pulse comprises at least one of: a duration of between 5-10 msec and an amplitude of between 7.5-10V.
A method of treating a heart, the method including providing an Implantable Pulse Generator (IPG) adapted to provide a combination of at least two treatment modalities including Cardiac Contractility Modulation therapy and one more modality selected from a group consisting of Cardiac pacing, Cardioversion, Defibrillation, Cardioversion and Defibrillation, and Cardiac Resynchronization Therapy (CRT), detecting a patient's physical condition, and selecting a combination of Cardiac Contractility Modulation therapy and at least one treatment modality from the group, and providing the combination of the Cardiac Contractility Modulation therapy and the at least one treatment modality. Related apparatus and methods are also described.
G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
19.
LEAD POSITIONING FOR AN IMPLANTABLE PULSE GENERATOR
A method of cardiac signal processing including: receiving measurements from at least two electrodes positioned within the heart; determining, using the measurements, relative positioning of the at least two electrodes relative to each other; evaluating suitability of the relative positioning of the at least two electrodes for measurement of cardiac activity to determine which cardiac cycles should receive cardiac contractility modulation stimulation.
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
A61N 1/372 - Arrangements in connection with the implantation of stimulators
A method of managing security of an implanted device including estimating a risk to, or a need of, a user in who the device is implanted; and automatically applying, by the device, a security level regarding communication to the device and/or actions by the device according, to said estimation. In some mebdoimnts, the need is a medical need, such as an emergency situation. In some mebdoimnts the risk is assessed base don a location of the implanted device.
A method of selecting a patient for cardiac contractility modulation therapy, comprising: selecting a patient meeting a criteria for cardiac resynchronization therapy (CRT); detecting a potential difficulty in effective delivery of CRT to the patient; and determining that the patient can benefit from cardiac contractility modulation therapy in spite of said potential difficulty.
A61N 1/40 - Applying electric fields by inductive or capacitive coupling
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
22.
CARDIAC CONTRACTILITY MODULATION IN ASSOCIATION WITH RESPIRATION
A system comprising: one or more sensors for detecting parameters of a respiratory cycle in a patient; and an implantable cardiac device comprising: at least one lead comprising one or more electrodes for applying cardiac contractility modulation stimulation to the heart; and circuitry for controlling and activating the leads, the circuitry programmed to set parameters of the cardiac contractility modulation stimulation according to the parameters of the respiratory cycle detected by the one or more sensors.
An implantable device containing a plurality of batteries, the plurality of batteries including at least one first non-rechargeable battery, and at least one second rechargeable battery. A method for providing power for a Cardiac Contractility Modulation Implantable Cardioverter Defibrillator (ICD) device, the method including providing power for cardioversion or defibrillation operation by a first, non-rechargeable battery, and providing power for Cardiac Contractility Modulation operation by a second, rechargeable battery. A method for controlling power for an implantable device having a rechargeable battery, a non-rechargeable battery and a Cardioverter Defibrillator module, the method including measuring electric power level of the rechargeable battery, comparing the rechargeable battery level to a threshold, if the electric power level of the rechargeable battery is less than the threshold, then providing power for the device from the non-rechargeable battery. Related apparatus and methods are also described.
A method of increasing peak VO2 including selecting a patient having impaired peak VO2 and estimated to have a potential for improving peak VO2, and applying cardiac contractility modulation stimulation to the patient's heart. A method of increasing peak VO2 including detecting ventricle contraction using one or more leads in a patient's ventricle, and applying Cardiac Contractility Modulation stimulation to the patient's ventricle, after a delay from a time of the detecting, thereby increasing the patient's peak VO2. Related apparatus and methods are also described.
decision circuitry which controls the stimulation circuitry to delivery said signal, also when said atrial arrhythmia detection circuitry detects an atrial arrhythmia.
A system for cardiac electrical stimulation treatment, comprising: an implantable pulse generator; one or more leads extending from the pulse generator to the heart for applying cardiac electrical stimulation; a controller programmed with at least one treatment plan for applying cardiac electrical stimulations, the controller configured to automatically update the treatment plan in response to actual cardiac activity by updating one or more parameters including: a time period during which cardiac electrical stimulations are applied; a rate of cardiac electrical stimulations; an amount of energy delivered at each cardiac electrical stimulation.
Some embodiments relate to a method of testing a lead condition in an implanted cardiac device comprising a first defibrillation lead and a second non-defibrillation lead, the method comprising: measuring impedance between the first defibrillation lead and the second non-defibrillation lead by applying a test pulse; and determining a condition of at least one of the defibrillation lead and the non-defibrillation lead according to the measured impedance value.
Embodiments of communication systems are disclosed for protecting communication between an implanted device ID and an external device ED. Optionally, the ID communicates over the TET channel by modulating a load on the channel. While the ID is communicating the ED optionally adds noise to the TET channel, inhibiting malicious interception of the communication. Using knowledge of the noise signal, the ED cleans the noise from the TET signal to recover the communication from the ID. In some embodiments, the TET link is used to pass an encryption key and/or to verify communications over a radio channel. The TET channel may be authenticated. For example, authentication may include a minimum energy and/or power transfer.
H04W 12/122 - Counter-measures against attacksProtection against rogue devices
H04B 5/00 - Near-field transmission systems, e.g. inductive or capacitive transmission systems
H04B 5/72 - Near-field transmission systems, e.g. inductive or capacitive transmission systems specially adapted for specific purposes for local intradevice communication
H04W 12/03 - Protecting confidentiality, e.g. by encryption
H04W 12/0431 - Key distribution or pre-distributionKey agreement
During a cardiac arrhythmia, defibrillation shocks from an implanted cardiac defibrillator are suppressed based on the sensing of electrical wavefront arrival times which indicate a supraventricular origin to the cardiac arrhythmia. In some embodiments, times of electrical wavefront arrival in at least two ventricular locations of the heart are sensed; one location being relatively superior, and one relatively inferior (e.g., relatively superior and inferior locations of a ventricular septum). In some embodiments, if the arrival time at the more inferior position is within a predetermined interval after arrival at the more superior position, delivery of defibrillation shocks are suppressed. In some embodiments, additional sensing of electrical wavefront arrival at one or more non-septal ventricular locations is performed, and defibrillation shock suppression is optionally itself suppressed if the additional sensing indicates that the wavefront initiated in a ventricular location.
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
Embodiments of communication systems are disclosed for protecting communication between an implanted device ID and an external device ED. For example, a one way Transcutaneous energy transfer TET link may be used to secure two way communication over a radio channel. Optionally, the TET link may be protected from intrusion by a malicious party. For example, the TET link may be over a medium that decays very quickly over distance. In some embodiments, the TET link is used to pass an encryption key and/or to verify communications over the two-way radio channel. The TET channel may be authenticated. For example, authentication may include a minimum energy and/or power transfer.
A system comprising: one or more sensors for detecting parameters of a respiratory cycle in a patient; and an implantable cardiac device comprising: at least one lead comprising one or more electrodes for applying cardiac contractility modulation stimulation to the heart; and circuitry for controlling and activating the leads, the circuitry programmed to set parameters of the cardiac contractility modulation stimulation according to the parameters of the respiratory cycle detected by the one or more sensors.
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
A61B 5/08 - Measuring devices for evaluating the respiratory organs
A61B 5/091 - Measuring volume of inspired or expired gases, e.g. to determine lung capacity
Methods and devices for tying management of an implantable medical device to the activities of a primary care physician are described, including access control, simplified parameter optimization, support for tuning a device in response to the effects of other treatments in parallel, and support for helping a primary physician and a patient work together to tune device configuration to the activity and performance needs of the patient. In some embodiments, a medical device is self-configuring in a device parameter domain, based on inputs provided in a patient performance domain. The self-configuring of the medical device is based, for example, on an automatically applied transformation of inputs derived from patient performance domain observations into changes in the configuration of the medical device which affect technical parameters of its operation.
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
A61M 60/148 - Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient’s body implantable via, into, inside, in line, branching on, or around a blood vessel in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
A61M 60/178 - Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient’s body implantable in, on, or around the heart drawing blood from a ventricle and returning the blood to the arterial system via a cannula external to the ventricle, e.g. left or right ventricular assist devices
A61M 60/508 - Electronic control means, e.g. for feedback regulation
G05B 15/02 - Systems controlled by a computer electric
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
A system for cardiac electrical stimulation treatment, comprising: an implantable pulse generator; one or more leads extending from the pulse generator to the heart for applying cardiac electrical stimulation; a controller programmed with at least one treatment plan for applying cardiac electrical stimulations, the controller configured to automatically update the treatment plan in response to actual cardiac activity by updating one or more parameters including: a time period during which cardiac electrical stimulations are applied; a rate of cardiac electrical stimulations; an amount of energy delivered at each cardiac electrical stimulation.
A61N 1/365 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential
A61B 5/0245 - Measuring pulse rate or heart rate using sensing means generating electric signals
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
35.
2 IN PATIENTS WITH HF USING CARDIAC CONTRACTILITY MODULATION STIMULATION
A method of increasing peak VO2 including selecting a patient having impaired peak VO2 and estimated to have a potential for improving peak VO2, and applying cardiac contractility modulation stimulation to the patient's heart. A method of increasing peak VO2 including detecting ventricle contraction using one or more leads in a patient's ventricle, and applying Cardiac Contractility Modulation stimulation to the patient's ventricle, after a delay from a time of the detecting, thereby increasing the patient's peak VO2. Related apparatus and methods are also described.
A61N 1/365 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
36.
CARDIAC CONTRACTILITY MODULATION FOR ATRIAL ARRHYTHMIA PATIENTS
A cardiac treatment device, including: stimulation circuitry configured to generate a non-excitatory electrical signal which, when applied to ventricular tissue during a ventricular refractory period thereof improves a condition of heart failure in human patients; atrial arrhythmia detection circuitry; and decision circuitry which controls the stimulation circuitry to delivery said signal, also when said atrial arrhythmia detection circuitry detects an atrial arrhythmia.
Methods and devices for tying management of an implantable medical device to the activities of a primary care physician are described, including access control, simplified parameter optimization, support for tuning a device in response to the effects of other treatments in parallel, and support for helping a primary physician and a patient work together to tune device configuration to the activity and performance needs of the patient. In some embodiments, a medical device is self-configuring in a device parameter domain, based on inputs provided in a patient performance domain. The self-configuring of the medical device is based, for example, on an automatically applied transformation of inputs derived from patient performance domain observations into changes in the configuration of the medical device which affect technical parameters of its operation.
A61M 5/172 - Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters electrical or electronic
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
A61M 60/00 - Blood pumpsDevices for mechanical circulatory actuationBalloon pumps for circulatory assistance
A61M 60/148 - Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient’s body implantable via, into, inside, in line, branching on, or around a blood vessel in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
Methods and devices for tying management of an implantable medical device to the activities of a primary care physician are described, including access control, simplified parameter optimization, support for tuning a device in response to the effects of other treatments in parallel, and support for helping a primary physician and a patient work together to tune device configuration to the activity and performance needs of the patient. In some embodiments, a medical device is self-configuring in a device parameter domain, based on inputs provided in a patient performance domain. The self-configuring of the medical device is based, for example, on an automatically applied transformation of inputs derived from patient performance domain observations into changes in the configuration of the medical device which affect technical parameters of its operation.
An implantable lead connector configured for long term implantation and to electrically interconnect multiple medical devices and to channel electrical signals between said interconnected devices and a target organ, comprising: a first port adapted to receive a first signal suitable to stimulate a target tissue, a second port adapted to receive a second signal suitable to stimulate a target tissue, and a third port configured to connect to a target organ, wherein at least one of said first and second ports is configured to connect to a signal generator not integrated with said connector.
An implantable lead connector configured for long term implantation and to electrically interconnect multiple medical devices and to channel electrical signals between said interconnected devices and a target organ, comprising: a first port adapted to receive a first signal suitable to stimulate a target tissue, a second port adapted to receive a second signal suitable to stimulate a target tissue, and a third port configured to connect to a target organ, wherein at least one of said first and second ports is configured to connect to a signal generator not integrated with said connector.
An implantable lead connector configured for long term implantation and to electrically interconnect multiple medical devices and to channel electrical signals between said interconnected devices and a target organ, comprising: a first port adapted to receive a first signal suitable to stimulate a target tissue, a second port adapted to receive a second signal suitable to stimulate a target tissue, and a third port configured to connect to a target organ, wherein at least one of said first and second ports is configured to connect to a signal generator not integrated with said connector.
Method and apparatus for modifying gene expression in cardiac muscle cells, by the application of electric fields. In some embodiments, the modification provides treatment of heart failure. Optionally, the treatment also provides an immediate improvement in cardiac function.
An implantable lead connector configured for long term implantation and to electrically interconnect multiple medical devices and to channel electrical signals between said interconnected devices and a target organ, comprising: a first port adapted to receive a first signal suitable to stimulate a target tissue, a second port adapted to receive a second signal suitable to stimulate a target tissue, and a third port configured to connect to a target organ, wherein at least one of said first and second ports is configured to connect to a signal generator not integrated with said connector.
A method of modifying cardiac tissue behavior, comprising applying a therapeutically effective electric field having an effect of modifying protein activation levels of at least one protein, and repeatedly applying the field at time intervals timed to increase the activation levels of the at least one protein beyond an activation level achieved by natural and/or paced excitation of the muscle without the application, to an extent about at least as high as a decay of the activation between applications of the field.
Devices, systems and methods for controlling (inhibiting or enabling) the delivery of electrotherapeutic signals to a heart using sensing of local and/or global ECG signals to detect ventricular arrhythmia or indication of possible ventricular arrhythmia in the heart. The devices, systems and methods process the sensed signals and are capable of delivering electroptherapeutic signals to the heart in the presence of a supra-ventricular arrhythmia such as atrial fibrillation and atrial flutter, while inhibiting the delivering electroptherapeutic signals in the presence of PVCs and/or extopic beats, and/or ventricular arrhythmia. The electrotherapeutic signals may include, among others, pacing signals and cardiac contractility modulating signals.
A method of assessing contractility of a cardiac muscle which has at least one activation parameter, the method comprising: (a) utilizing time correlated data pertaining to at least one activation parameter to produce a profile of said parameter; (b) identifying from measurement of said at least one parameter a time interval during which interference from an artificial signal occurs; (c) ameliorating effects of said interference; and (d) analyzing changes in said profile to generate an indication of contractility, as a function of time to generate a cardiac activation profile.
H02J 7/00 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries
H02J 7/02 - Circuit arrangements for charging or depolarising batteries or for supplying loads from batteries for charging batteries from AC mains by converters
