09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Clinical research laboratory analyzers for analysis of
bodily fluids; downloadable computer software for quality
control of clinical research data, clinical research
laboratory analyzers, medical data and medical diagnostic
instruments. Medical diagnostic instruments for the analysis of bodily
fluids; medical apparatus and instruments for medical
diagnostic testing; blood analyzers for medical diagnostic
and critical care diagnostic use; medical apparatus, namely,
medical instruments for testing, analysis and reporting on
basic metabolic indicators, namely, glucose, electrolyte,
fluid balance, kidney function; apparatus for blood analysis
for use by physicians for diagnostic and critical care.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Clinical research laboratory analyzers for analysis of
bodily fluids; downloadable computer software for quality
control of clinical research data, clinical research
laboratory analyzers, medical data and medical diagnostic
instruments. Medical diagnostic instruments for the analysis of bodily
fluids; medical apparatus and instruments for medical
diagnostic testing; blood analyzers for medical diagnostic
and critical care diagnostic use; medical apparatus, namely,
medical instruments for testing, analysis and reporting on
basic metabolic indicators, namely, glucose, electrolyte,
fluid balance, kidney function; apparatus for blood analysis
for use by physicians for diagnostic and critical care.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
(1) Clinical research laboratory analyzers for analysis of bodily fluids; downloadable computer software for quality control of clinical research data, clinical research laboratory analyzers, medical data and medical diagnostic instruments.
(2) Medical diagnostic instruments for the analysis of bodily fluids; medical apparatus and instruments for medical diagnostic testing; blood analyzers for medical diagnostic and critical care diagnostic use; medical apparatus, namely, medical instruments for testing, analysis and reporting on basic metabolic indicators, namely, glucose, electrolyte, fluid balance, kidney function; apparatus for blood analysis for use by physicians for diagnostic and critical care.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
(1) Clinical research laboratory analyzers for analysis of bodily fluids; downloadable computer software for quality control of clinical research data, clinical research laboratory analyzers, medical data and medical diagnostic instruments.
(2) Medical diagnostic instruments for the analysis of bodily fluids; medical apparatus and instruments for medical diagnostic testing; blood analyzers for medical diagnostic and critical care diagnostic use; medical apparatus, namely, medical instruments for testing, analysis and reporting on basic metabolic indicators, namely, glucose, electrolyte, fluid balance, kidney function; apparatus for blood analysis for use by physicians for diagnostic and critical care.
An example cartridge includes a base having a channel configured to receive fluid, where the fluid includes a test sample to be tested on the cartridge, and a structure including at least part of a fluidic duct. The structure is configured to move relative to the base between a first position and a second position. In the first position, the channel and fluidic duct are aligned to create a fluidic connection between the channel and the fluidic duct and, in the second position, the channel and the fluidic duct are unaligned to block a fluidic connection between the channel and the fluidic duct.
An example method detecting a presence of one or more oral anticoagulants or intravenous (IV) direct thrombin inhibitors in a blood sample may include the following operations: receiving parameters that are based on viscoelastic tests; comparing the parameters to predefined threshold values, where the parameters and the predefined threshold values are based on an identity of the one or more oral anticoagulants or the IV direct thrombin inhibitors; and detecting, based on the comparing, the presence of the one or more oral anticoagulants or IV direct thrombin inhibitors in the blood sample. The viscoelastic tests are performed on portions of the blood sample to obtain the parameters. The viscoelastic tests include both a viscoelastic test based on Ecarin activation and a viscoelastic test with low tissue factor activation.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G01N 11/00 - Investigating flow properties of materials, e.g. viscosity or plasticityAnalysing materials by determining flow properties
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
An example cartridge includes a base having a channel configured to receive fluid, where the fluid includes a test sample to be tested on the cartridge, and a structure including at least part of a fluidic duct. The structure is configured to move relative to the base between a first position and a second position. In the first position, the channel and fluidic duct are aligned to create a fluidic connection between the channel and the fluidic duct and, in the second position, the channel and the fluidic duct are unaligned to block a fluidic connection between the channel and the fluidic duct.
A device and method for analyte detection and analytes in a particulate bearing fluid such as whole blood having an instrument for partitioning the particles from the fluid that is integrated with a detector for analyses of one or more particulate bearing fluid analytes while the particles in the particulate bearing fluid are partitioned.
An example composition that is liquid includes thrombin and a constituent that includes one or more of guanidine derivatives or one or more anticoagulants. The one or more guanidine derivative may include 1-methylguanidine, 1,1-dimethylguanidine, 1,1-diethylguanidine, or N-benzyl-N-methylguanidine. The one or more anticoagulants may include rivaroxaban, apixaban, edoxaban, betrixaban, or a factor Xa anticoagulant.
C07C 279/14 - Derivatives of guanidine, i.e. compounds containing the group the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
The embodiments of the present disclosure provide a stopper comprising a plug and a pierceable membrane, the plug including a cavity between a pierceable membrane and a lower opening. The pierceable membrane and the cavity can form a tortuous path that reduces interactions between the contents of the container and the ambient environment. The cavity can be bounded by a plastic insert disposed within the plug. The plastic insert can include insert walls, the lower opening, and an insert flange. The pierceable membrane can be bonded to an upper surface of the insert flange.
Technology described herein includes a method that includes obtaining an image of a fluid of a microfluidic analysis system. The microfluidic analysis system includes or receives a container that contains the fluid for measurement of analyte or quality determination. A region of interest (ROI) is identified based on the image. The ROI is a set of pixel values for use in the measurement of the analyte or the quality determination of the fluid, fluidic path, or measuring system. Identifying the ROI includes: determining an alignment of the container of the fluid with the imaging device based on the image, and identifying the ROI based on information about the measurement of the fluid or based on information about non-analyte features of the fluid. An analysis of the image of the fluid is performed using the set of pixel values of the ROI.
A system comprising a tray and methods of loading and unloading units for sample racks. The system provides a tray for loading and unloading of samples to a system, wherein the tray comprises a base plate comprising on its upper surface a longitudinal extending guiding rail which is arranged closer to one of the two longitudinal sides of the tray, wherein the tray comprises at least one element that is configured to extend through an opening in the upper surface of the base plate, when the tray is lifted from a surface. Further, a system, comprising a tray as described above; and at least one rack comprising on its lower surface an acceptance slot configured for accommodating a guiding rail of the tray, and a loading area comprising two toothed conveyer belts arranged in a distance corresponding to the trays width.
An apparatus includes a probe configured to provide at least a portion of capacitance of an inductance-capacitance (LC) circuit of a detection circuit, the capacitance of the LC circuit being dependent on a distance between the probe and a surface of a liquid in a biochemical analysis system. The apparatus includes a movement mechanism configured to move the probe. The apparatus includes circuitry configured to perform operations that include causing the movement mechanism to move the probe with respect to the liquid; measuring one or more characteristics of an output signal of the detection circuit, the one or more characteristics being dependent on the capacitance of the LC circuit; and detecting, based on the one or more characteristics of the output signal, a contact between the probe and the surface of the liquid.
G01F 23/26 - Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water by measuring variations of capacity or inductance of capacitors or inductors arising from the presence of liquid or fluent solid material in the electric or electromagnetic fields
G01F 23/263 - Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water by measuring variations of capacity or inductance of capacitors or inductors arising from the presence of liquid or fluent solid material in the electric or electromagnetic fields by measuring variations in capacitance of capacitors
Technology described in this document can be embodied in a system for detecting analytes in a biochemical sample. The system includes a container configured to contain the biochemical sample. The system also includes a light source, an optical detector, a lens, and an optical aperture. The lens is disposed between the container and the optical detector, and the optical aperture is disposed between the lens and the optical detector. The system further includes a structure configured to house the container, the optical aperture, the lens, and the optical detector.
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
Diagnostic testing apparatus in the nature of cartridges
comprised of analytical sensors and reagents for in vitro
diagnostic purposes for measuring, testing and analyzing
blood and other bodily fluids.
Technology described herein includes a method that includes providing, by an optical light source, a light beam configured to traverse an optical path through a fluid comprising the biological sample in a container. A length of the optical path through the fluid is between 3.3 mm to 5.5 mm, and a center of the light beam is at a height less than 1.6 mm from a bottom interior surface of the container, and a volume of the fluid is less than 120 μL. An optical detector receives optical information after the light beam traverses the optical path. An output of the optical detector is associated with at least one parameter representing the one or more characteristics of the biological sample.
An example method includes: analyzing a clot curve for a test sample that is based on an assay performed on the test sample in order to obtain two or more parameters associated with the clot curve; analyzing the two or more parameters to determine at least one of (i) whether a fibrinogen concentration in the test sample is below a threshold, or (ii) whether there is a therapeutic or pharmaceutical anticoagulant present in the test sample; and outputting, to a user interface, information based on the determination.
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
G01N 33/86 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood coagulating time
C12Q 1/56 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
An example sensor includes a conductive electrode and an ion-selective membrane over the conductive electrode. The ion-selective membrane includes an ionophore that is selective for ionized magnesium (iMg) and at least two types of anionic lipophilic salts. The at least two types of anionic lipophilic salts may include one or more fluorinated borate salts and one or more chlorinated borate salts.
An example medical diagnostic system includes one or more containers that are usable in a medical diagnostic test. Each container has an identification (ID) tag associated therewith. An ID tag of a container includes memory that is readable and writeable. The memory is for storing information relating to the container. Antennas are configured to communicate wirelessly with ID tags associated with the one or more containers. A control system is configured to store a location of the container based on an identify of the antenna, to select the antenna for communication with the ID tag, and to use the antenna to read at least some of the information from, or to write at least some of the information to, the memory on the ID tag.
An example sensor includes a conductive electrode and an ion-selective membrane over the conductive electrode. The ion-selective membrane includes an ionophore that is selective for ionized magnesium (iMg) and at least two types of anionic lipophilic salts. The at least two types of anionic lipophilic salts may include one or more fluorinated borate salts and one or more chlorinated borate salts.
An example method includes the following operations: obtaining a dotting parameter based on a mixture including a test sample and a reagent, where the reagent includes a polycation; using the dotting parameter to identify at least one of a potential presence of a direct oral factor Xa inhibitor in the test sample or an estimated concentration of the direct oral factor Xa inhibitor in the test sample; and reporting a result that is based on the potential presence or the estimated concentration,
Systems and methods for probe tip heating are disclosed. An exemplary system for probe tip heating can include an enclosure enclosing a probe tip, a heating device, and a fan. The probe tip can be configured to access an internal volume of a stoppered container and to aspirate or dispense a material from or to the internal volume of the stoppered container. The heating device can be configured to heat air circulating within the enclosure. The fan can be positioned to circulate air within the enclosure to heat the tip of the probe.
Technology described herein includes a method that includes obtaining an image of a fluid of a microfluidic analysis system. The microfluidic analysis system includes or receives a container that contains the fluid for measurement of analyte or quality determination. A region of interest (ROI) is identified based on the image. The ROI is a set of pixel values for use in the measurement of the analyte or the quality determination of the fluid, fluidic path, or measuring system. Identifying the ROI includes: determining an alignment of the container of the fluid with the imaging device based on the image, and identifying the ROI based on information about the measurement of the fluid or based on information about non-analyte features of the fluid. An analysis of the image of the fluid is performed using the set of pixel values of the ROI.
(1) Diagnostic testing apparatus in the nature of cartridges comprised of analytical sensors and reagents for in vitro diagnostic purposes for measuring, testing and analyzing blood and other bodily fluids.
31.
Preparing substances in a medical diagnostic system
Operations performed according to the example techniques described herein include controlling a probe to pierce a stopper of a container containing a substance, where the stopper provides an air-tight seal for the container, and where the air-tight seal supports an internal pressure in the container. The operations also include detecting the internal pressure based on information from a pressure sensor; determining that the internal pressure is not at a target pressure and, based on determining that the internal pressure is not at the target pressure, controlling the probe either to aspirate air from the container or to dispense air into the container in order to move the internal pressure toward the target pressure.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Chemical preparations, namely, chemical reagents and diagnostic preparations for scientific or research use Chemical reagents, diagnostic reagents and diagnostic preparations for medical or veterinary purposes; medical diagnostic reagents and assays, namely, immunoassays and functional assays for blood and bodily fluid testing Clinical laboratory analyzers and components thereof for measuring, testing and analyzing blood and other bodily fluids; medical instruments for laboratory research and diagnostic use, namely, blood analyzers, blood gas and immunoglobin analyzers, coagulation analyzers, optical analyzers and medical instruments comprising blood gas, electrolyte, CO-oximetry, and bilirubin analyzers for analysis of blood and bodily fluids; downloadable and recorded computer software allowing user access to medical data on a blood gas analyzer from a display or a networked computer workstation via a web browser interface; downloadable and recorded computer software and mobile application software that provides access to applications and services through a web operating system or portal interface in the fields of medical and clinical laboratory analysis and instruments; downloadable and recorded computer software for regulatory compliance management; cartridges comprised of analytical sensors and reagents for in vitro diagnostic purposes for measuring, testing and analyzing blood and other bodily fluids Optical analyzers for medical use; blood analyzers and components of for medical diagnostic use; medical apparatus, namely, medical instruments comprising blood gas, electrolyte, CO-oximetry and bilirubin analyzers for analysis of blood and bodily fluids including optical analyzers; apparatus for blood analysis for point-of-care applications and use by physicians for diagnostic purposes; disposable cartridges containing reagents, disposable vessels containing reagents, disposable sample holders, and mixing tubes for diagnostic testing of body fluids in an automated body fluid analyzer; sensors for detecting the presence of analytes in body fluids; calibration devices for calibrating medical instruments, namely, clinical laboratory analyzers and blood analyzers Providing an Internet website featuring non-downloadable software that enables users to monitor the performance of and to manage customer service queries in the fields of medical and clinical laboratory analysis and instruments, namely, blood analyzers, blood gas and immunoglobin analyzers, coagulation analyzers, and medical instruments comprising blood gas, electrolyte, CO-oximetry, hemolysis, and bilirubin analyzers for analysis of blood and bodily fluids; technical support services, namely, troubleshooting of computer software, diagnosing problems with medical and scientific equipment
A cleaning device, and method of using the same, for cleaning a probe. The device includes a body defining an inner chamber. An air intake is connected to at least one air channel through the body, the at least one air channel configured to allow air from the air intake to flow into the inner chamber and towards the inner chamber. A liquid intake is connected to at least one liquid channel through the body, the at least one liquid channel configured to allow liquid from the liquid intake to flow into the inner chamber.
The embodiments of the present disclosure provide a pierceable stopper, comprising a plug portion, and a disk portion disposed on top of the plug portion and comprising a flange extending radially beyond an outer diameter of the plug portion. The embodiments also provide a lyophilization stopper, comprising a body comprising an integral hinge means, and a flange extending radially beyond an outer diameter of the body. Additionally, the embodiments provide a probe assembly, comprising a first needle comprising a hollow cavity and a pointed tip, and a second needle disposed inside the hollow cavity and comprising a rounded tip. The embodiments further provide a cartridge assembly, comprising a first housing comprising a first set of cavities configured to accommodate one or more containers, and a second housing comprising a second set of cavities corresponding to the first set of cavities when the second housing is coupled to the first housing.
An example blood cell lysis composition includes a buffer and a secondary alcohol ethoxylate at a concentration in the range of about 2.5 percent (%) to about 20% weight per volume (w/v). The secondary alcohol ethoxylate may include Tergitol™ TMN-100X or Tergitol™ 15-S-9. The composition may be configured to lyse at least 90% of blood cells in a blood sample.
An example system includes a chamber to hold a mixture that includes a whole blood sample from a patient, a light source to illuminate the mixture in the chamber, a detector to detect light from the light source transmitted through the mixture in the chamber, and one or more processing devices to determine, based on the light detected by the detector, a platelet aggregation value of the whole blood sample that is substantially independent of a hematocrit of the whole blood sample.
A61B 5/1459 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
G01N 21/49 - Scattering, i.e. diffuse reflection within a body or fluid
09 - Scientific and electric apparatus and instruments
Goods & Services
cartridges comprised of analytical sensors and reagents for in vitro diagnostic purposes for measuring, testing and analyzing blood and other bodily fluids
38.
MULTI-ENZYMATIC BIOSENSORS AND STABILIZATION OF MULTI-ENZYMATIC BIOSENSORS AT ROOM TEMPERATURE
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
G01N 27/333 - Ion-selective electrodes or membranes
G01N 33/70 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving creatine or creatinine
G01N 33/96 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood or serum control standard
G01N 27/30 - Electrodes, e.g. test electrodesHalf-cells
C12Q 1/54 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving glucose or galactose
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
The present disclosure relates to biocide compositions compatible with enzyme biosensors and methods for using same. More particularly, the disclosure relates to biocide compositions compatible with enzymes used for measuring creatine and creatinine levels.
C12Q 1/18 - Testing for antimicrobial activity of a material
C12Q 1/34 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase
An apparatus for measuring hemolysis in a cartridge based automated blood analyzer is described. The apparatus allows hemolysis testing to be performed on a sample which is presented as a whole blood sample for other testing by the cartridge based automated blood analyzer. A disposable module is configured for optically analyzing one or more plasma analytes in a flow cell while red blood cells are acoustically separated from plasma in the flow cell.
A device and method for analyte detection and analytes in a particulate bearing fluid such as whole blood having an instrument for partitioning the panicles from the fluid that is integrated with a detector for analyses of one or more particulate bearing fluid analytes while the particles in the particulate bearing fluid are partitioned.
An example method detecting a presence of one or more oral anticoagulants or intravenous (IV) direct thrombin inhibitors in a blood sample may include the following operations: receiving parameters that are based on viscoelastic tests; comparing the parameters to predefined threshold values, where the parameters and the predefined threshold values are based on an identity of the one or more oral anticoagulants or the IV direct thrombin inhibitors; and detecting, based on the comparing, the presence of the one or more oral anticoagulants or IV direct thrombin inhibitors in the blood sample. The viscoelastic tests are performed on portions of the blood sample to obtain the parameters. The viscoelastic tests include both a viscoelastic test based on Ecarin activation and a viscoelastic test with low tissue factor activation.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G01N 11/00 - Investigating flow properties of materials, e.g. viscosity or plasticityAnalysing materials by determining flow properties
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
This invention relates to an optical system and method for performing turbidity assay, e.g. coagulation of blood or plasma, comprising a standard optical reference, a sample handling structure, a light source and an optical detection unit. The standard optical reference, such as a fluorophore-doped glass, provides constant optical signal under controlled optical conditions. The sample handling structure, such as a microfluidic system with reaction chamber, can be placed beneath or above the standard optical reference. During operation, the coagulating plasma/blood changes its optical absorbance and reflection properties, which results in changes in optical signal that reaches the optical reading unit. The variation of the optical signal, such as fluorescence signal indicates the kinetics of the turbidity varying process, such as plasma/blood coagulation process. This invention is used for performing turbidity assay with optical system, including photometry system, fluorescence system, Raman Spectroscopy system and so on.
The invention relates to a method of performing an optical or electrical measurement in a sample of a disperse fluid, the sample comprising particles and a fluid. The method comprises the steps of: a) positioning the sample in a microfluidic cavity having a resonance frequency, b) subjecting the sample, in the cavity, to an acoustic standing wave configured for causing the particles to congregate in at least one first region of the cavity, thereby causing the fluid to occupy at least one second region of the cavity, wherein the frequency of the acoustic standing wave is varied between a frequency below the resonance frequency and a frequency above the resonance frequency, and c) performing an optical or electrical measurement in the fluid in at least one of the at least one second region of the cavity. Varying the frequency ensures reproducible results. The invention also relates to a system therefore and a method and system for measuring hematocrit.
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
G01N 29/22 - Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic wavesVisualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object Details
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Clinical research laboratory analyzers for analysis of bodily fluids; downloadable computer software for quality control of clinical research data, clinical research laboratory analyzers, medical data and medical diagnostic instruments Medical diagnostic instruments for the analysis of bodily fluids; medical apparatus and instruments for medical diagnostic testing; Blood analyzers for medical diagnostic and critical care diagnostic use; medical apparatus, namely, medical instruments for testing, analysis and reporting on basic metabolic indicators, namely, glucose, electrolyte, fluid balance, kidney function; apparatus for blood analysis for use by physicians for diagnostic and critical care
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Clinical research laboratory analyzers for analysis of bodily fluids; downloadable computer software for quality control of clinical research data, clinical research laboratory analyzers, medical data and medical diagnostic instruments Medical diagnostic instruments for the analysis of bodily fluids; medical apparatus and instruments for medical diagnostic testing; Blood analyzers for medical diagnostic and critical care diagnostic use; medical apparatus, namely, medical instruments for testing, analysis and reporting on basic metabolic indicators, namely, glucose, electrolyte, fluid balance, kidney function; apparatus for blood analysis for use by physicians for diagnostic and critical care
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Hemostasis laboratory automation systems, namely, data
management and laboratory computer hardware; data management
and laboratory automation systems comprised of computer
hardware and software for use in the fields of hemostasis
and medical diagnostics; laboratory equipment used to
automate the sorting of laboratory samples; data management
and laboratory computer hardware; data management and
laboratory automation systems comprised of computer hardware
and software for use in the fields of medical diagnostics
and hemostasis; data management computer software and
hardware sold as a unit. Hemostasis laboratory automation systems and parts therefor,
namely, medical apparatus for medical diagnostic testing in
the field of hemostasis; laboratory equipment for use in the
fields of hemostasis and medical diagnostics, namely,
automation equipment to automate the sorting of laboratory
samples; medical sample tube sorting apparatus; sample
container transfer apparatus for medical purposes;
laboratory automation systems for use in the field of
hemostasis analysis and medical diagnostics; diagnostic
instruments for medical use, namely, automated coagulation
analyzers for measuring clotting characteristics and
clotting constituents in blood; hemostasis laboratory
apparatus for medical diagnostic analysis of body fluids and
structural parts therefor.
A rack for automated analyser systems and provides a rack for automated analyser systems, the rack comprising a main body having an extended front side and a corresponding extended reverse side as well as at least two side walls defining at least one opening that is accessible from the main body's upper side for taking up a container for a sample that is to be processed; an upper insert that is arranged onto an upper end of the main body, wherein the upper insert has openings with a predefined diameter defining the upper surface of the rack.
G01N 35/02 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
G01N 35/00 - Automatic analysis not limited to methods or materials provided for in any single one of groups Handling materials therefor
Aspects of the present disclosure include a titration probe that mitigate the occurrences of titration probe clots. A bar such as segment of music wire, is extended across the tip of a titration probe and attached at both ends to the titration probe. The bar is configured to catch clots and prevent the clots from being collected along with a blood sample to be analyzed. The bar effectively reduces the cross sectional area of the titration probe tip.
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
G01N 33/86 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood coagulating time
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
53.
LUPUS ANTICOAGULANT (LA) MIXING METHOD AND KIT WITH REDUCED FACTOR DEFICIENCY EFFECT AND REDUCED INHIBITOR INTERFERENCE FOR IDENTIFYING LA ASSOCIATED WITH ANTIPHOSPHOLIPID SYNDROME
The invention described herein relates to a kit for the diagnosis of antiphospholipid syndrome in patients, wherein a coagulation inhibitor and normal pooled plasma mixture reduce the factor deficiency effect of patient plasma, and coagulation inhibitor interference in patient plasma, and increases specificity and the sensitivity for detecting lupus anticoagulants in the patient's blood in a phospholipid-dependent clotting assay.
The present disclosure relates to biocide compositions compatible with enzyme biosensors and methods for using same. More particularly, the disclosure relates to biocide compositions compatible with enzymes used for measuring creatine and creatinine levels.
C12Q 1/18 - Testing for antimicrobial activity of a material
C12Q 1/34 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving hydrolase
G01N 33/70 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving creatine or creatinine
55.
BIOCIDE COMPOSITIONS COMPATIBLE WITH ENZYME BIOSENSORS AND METHODS OF USE THEREOF
The present disclosure relates to biocide compositions compatible with enzyme biosensors and methods for using same. More particularly, the disclosure relates to biocide compositions compatible with enzymes used for measuring creatine and creatinine levels.
G01N 33/96 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood or serum control standard
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
Goods & Services
Chemical preparations and reagents for use in quality
control of medical and scientific equipment. Computer software for quality control of medical data and
medical diagnostic instruments.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Clinical research laboratory analyzers for measuring,
testing and analyzing blood and other bodily fluids;
clinical research laboratory analyzers for measuring,
testing and analyzing basic metabolic indicators, namely,
glucose, electrolyte, fluid balance, kidney function. Blood analyzers for medical diagnostic and critical care
diagnostic use; medical apparatus, namely, medical
instruments for testing, analysis and reporting on basic
metabolic indicators, namely, glucose, electrolyte, fluid
balance, kidney function; apparatus for blood analysis for
use by physicians for diagnostic and critical care
diagnostic purposes.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemical preparations, namely, chemical reagents and
diagnostic preparations for scientific or research use. Chemical reagents and diagnostic preparations for clinical,
medical or veterinary purposes.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemical preparations, namely, chemical reagents and
diagnostic preparations for scientific or research use. Chemical preparations, namely, chemical reagents and
diagnostic preparations for clinical, medical, or veterinary
purposes.
61.
Two component “mix and use” liquid thromboplastin reagent, methods of making, and methods of use thereof
What is described is a kit for preparing a liquid thromboplastin reagent for a prothrombin time assay. The kit simplifies and minimizes reagent preparation time and is stable for 2-5 years.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Chemical preparations, namely, chemical reagents and diagnostic preparations for scientific or research use
(2) Chemical preparations, namely, chemical reagents and diagnostic preparations for clinical, medical, or veterinary purposes
63.
COMPOSITIONS AND METHODS FOR IMPROVED CALIBRATION ACCURACY OF CREATININE/CREATINE SENSORS AND USES THEREOF
The present disclosure relates to electrochemical sensors for measuring creatinine and creatine in a patient's blood. More particularly, the disclosure relates to compositions and methods for improving calibration accuracy of electrochemical sensors used for measuring creatinine and creatine.
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G06F 17/18 - Complex mathematical operations for evaluating statistical data
The disclosure relates to electrochemical sensors for measuring creatinine and creatine in a patient's blood. More particularly, the disclosure relates to compositions and methods for improving measurement accuracy of electrochemical sensors used for measuring creatinine and creatine.
G01N 33/70 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving creatine or creatinine
G01N 33/96 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood or serum control standard
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
G01N 27/333 - Ion-selective electrodes or membranes
G01N 27/30 - Electrodes, e.g. test electrodesHalf-cells
C12Q 1/54 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving glucose or galactose
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G06F 17/18 - Complex mathematical operations for evaluating statistical data
C12Q 1/58 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving urea or urease
G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
G06F 30/331 - Design verification, e.g. functional simulation or model checking using simulation with hardware acceleration, e.g. by using field programmable gate array [FPGA] or emulation
65.
UREA BIOSENSORS AND STABILIZATION OF UREA BIOSENSORS AT ROOM TEMPERATURE
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
66.
COMPOSITIONS AND METHODS FOR IMPROVED CREATININE MEASUREMENT ACCURACY AND USES THEREOF
The disclosure relates to electrochemical sensors for measuring creatinine and creatine in a patient's blood. More particularly, the disclosure relates to compositions and methods for improving measurement accuracy of electrochemical sensors used for measuring creatinine and creatine.
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
G01N 27/00 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
67.
MULTI-ENZYMATIC BIOSENSORS AND STABILIZATION OF MULTI-ENZYMATIC BIOSENSORS AT ROOM TEMPERATURE
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
68.
IMPROVED CALIBRATION ACCURACY METHOD FOR CREATININE/CREATINE SENSORS
The present disclosure relates to electrochemical sensors for measuring creatinine and creatine in a patient's blood. More particularly, the disclosure relates to compositions and methods for improving calibration accuracy of electrochemical sensors used for measuring creatinine and creatine.
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
The disclosure relates to electrochemical sensors for measuring creatinine and creatine in a patient's blood. More particularly, the disclosure relates to compositions and methods for improving measurement accuracy of electrochemical sensors used for measuring creatinine and creatine.
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
G01N 27/00 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
70.
OUTER MEMBRANE COMPOSITIONS FOR CREATININE/CREATINE SENSORS
Disclosed herein are compositions for permeable outer diffusion control membranes for creatinine and creatine sensors and methods of making such membranes.
B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
G01N 27/333 - Ion-selective electrodes or membranes
G01N 33/70 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving creatine or creatinine
G01N 33/96 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood or serum control standard
G01N 27/30 - Electrodes, e.g. test electrodesHalf-cells
C12Q 1/54 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving glucose or galactose
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G06F 17/18 - Complex mathematical operations for evaluating statistical data
C12Q 1/58 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving urea or urease
G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
G06F 30/331 - Design verification, e.g. functional simulation or model checking using simulation with hardware acceleration, e.g. by using field programmable gate array [FPGA] or emulation
72.
Urea biosensors and stabilization of urea biosensors at room temperature
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
G01N 27/333 - Ion-selective electrodes or membranes
G01N 33/70 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving creatine or creatinine
G01N 33/96 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood or serum control standard
G01N 27/30 - Electrodes, e.g. test electrodesHalf-cells
C12Q 1/54 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving glucose or galactose
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G06F 17/18 - Complex mathematical operations for evaluating statistical data
C12Q 1/58 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving urea or urease
G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
G06F 30/331 - Design verification, e.g. functional simulation or model checking using simulation with hardware acceleration, e.g. by using field programmable gate array [FPGA] or emulation
73.
Outer membrane compositions for creatinine/creatine sensors
Disclosed herein are compositions for permeable outer diffusion control membranes for creatinine and creatine sensors and methods of making such membranes.
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
G01N 27/333 - Ion-selective electrodes or membranes
G01N 33/70 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving creatine or creatinine
G01N 33/96 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood or serum control standard
G01N 27/30 - Electrodes, e.g. test electrodesHalf-cells
C12Q 1/54 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving glucose or galactose
G16H 10/40 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for data related to laboratory analysis, e.g. patient specimen analysis
G06F 17/18 - Complex mathematical operations for evaluating statistical data
C12Q 1/58 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving urea or urease
G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
G06F 30/331 - Design verification, e.g. functional simulation or model checking using simulation with hardware acceleration, e.g. by using field programmable gate array [FPGA] or emulation
74.
IMPROVED CALIBRATION ACCURACY METHOD FOR CREATININE/CREATINE SENSORS
The present disclosure relates to electrochemical sensors for measuring creatinine and creatine in a patient's blood. More particularly, the disclosure relates to compositions and methods for improving calibration accuracy of electrochemical sensors used for measuring creatinine and creatine.
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
Disclosed herein are compositions for permeable outer diffusion control membranes for creatinine and creatine sensors and methods of making such membranes.
B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemical preparations, namely, chemical reagents and diagnostic preparations for scientific or research use; Chemicals for use in industry, science and photography, as well as in agriculture, horticulture and forestry; Biological preparations for use in industry and science. Chemical reagents and diagnostic preparations for clinical, medical or veterinary purposes; Pharmaceuticals, medical and veterinary preparations.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Chemical preparations, namely, chemical reagents and diagnostic preparations for scientific or research use; Chemicals for use in industry, science and photography, as well as in agriculture, horticulture and forestry; Biological preparations for use in industry and science. Chemical preparations, namely, chemical reagents and diagnostic preparations for clinical, medical, or veterinary purposes; Pharmaceuticals, medical and veterinary preparations.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
chemical preparations, namely, chemical reagents and diagnostic preparations for scientific or research use chemical reagents and diagnostic preparations for clinical, medical or veterinary purposes
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
chemical preparations, namely, chemical reagents and diagnostic preparations for scientific or research use chemical preparations, namely, chemical reagents and diagnostic preparations for clinical, medical, or veterinary purposes
80.
HEMATOCRIT LEVEL DETECTION USING IR LASER REFRACTION
Principals of refraction of a light ray are used to identify the location of an interface between two materials having different refractive indices. The interface may be an interface between a plasma layer and a red blood cell layer of a centrifuged container, for example. An array of light detector elements are arranged to receive light that has been refracted through different layers in a centrifuged sample. Elements of the light detector array are arranged at known locations relative to an emitter of the light so detection of light by one or more particular detector elements is indicative of the angle of refraction of the light. Vertical position of the sample is tracked and correlated with corresponding angles of refraction to determine the vertical position of the sample when a change in the angle of diffraction is detected.
Principals of refraction of a light ray are used to identify the location of an interface between two materials having different refractive indices. The interface may be an interface between a plasma layer and a red blood cell layer of a centrifuged container, for example. An array of light detector elements are arranged to receive light that has been refracted through different layers in a centrifuged sample. Elements of the light detector array are arranged at known locations relative to an emitter of the light so detection of light by one or more particular detector elements is indicative of the angle of refraction of the light. Vertical position of the sample is tracked and correlated with corresponding angles of refraction to determine the vertical position of the sample when a change in the angle of diffraction is detected.
A system and method for lysing of whole blood for CO-Ox measurement uses a lysing chamber for acoustic lysing of whole blood in a module in which the lysing chamber is separate from a CO-Ox measurement chamber. The disclosed acoustic lysing system and method avoids the expense and complexity of chemical lysing methods and allows the whole blood sample to be lysed while under continuous flow through the lysing chamber. The acoustic lysing chamber is provided upstream from a CO-Ox measurement chamber. The separation of the lysing chamber from the Co-Ox measurement chamber provides freedom to arrange and orient various optical components and/or other CO-Ox measuring components around the CO-Ox measurement chamber. The decoupling of the lysing chamber from the CO-Ox measurement chamber allows for more efficient design of the ultrasonic lysing transducer and CO-Ox measurement optics.
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
G01N 33/72 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving blood pigments, e.g. hemoglobin, bilirubin
A system and method for lysing of whole blood for CO-Ox measurement uses a lysing chamber for acoustic lysing of whole blood in a module in which the lysing chamber is separate from a CO-Ox measurement chamber. The disclosed acoustic lysing system and method avoids the expense and complexity of chemical lysing methods and allows the whole blood sample to be lysed while under continuous flow through the lysing chamber. The acoustic lysing chamber is provided upstream from a CO-Ox measurement chamber. The separation of the lysing chamber from the Co-Ox measurement chamber provides freedom to arrange and orient various optical components and/or other CO-Ox measuring components around the CO-Ox measurement chamber. The decoupling of the lysing chamber from the CO-Ox measurement chamber allows for more efficient design of the ultrasonic lysing transducer and CO-Ox measurement optics.
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Providing non-downloadable software application to enable users to access, transmit, receive, process, display and store data and to access computer applications and services through a web operating system or portal interface for use in the fields of in vitro diagnostic testing, and medical and clinical laboratory analysis via an Internet website; technical support services, namely, troubleshooting of computer software and hardware, diagnosing problems with medical and scientific equipment
42 - Scientific, technological and industrial services, research and design
Goods & Services
Scientific services and design relating thereto; Technological services and design relating thereto; Science and technology services; Scientific research; Technological research; design and development of computer hardware and software; hosting an Internet website featuring non-downloadable software that enables users to access, transmit, receive, process, display and/or store data and/or to access computer applications and services through a web operating system or portal interface for use in the fields of in vitro diagnostic testing, and medical and clinical laboratory analysis; technical support services, troubleshooting of computer software and hardware, diagnosing problems with medical and scientific equipment; advice and consultancy services relating to the aforesaid services.
86.
Container stopper for high pierce count applications
A pierceable self-resealing stopper for a container is disclosed. The disclosed stopper is suitable for sealing a container containing reagents for use in a high-throughput analysis system in which reagents in the container are accessed by an aspirator probe piercing the stopper. The stopper is configured for being pierced and resealing itself a large number of times without degradation of the stopper by coring or fragmentation, for example. A set of protrusions extending from a top surface of the stopper is depressed to stretch a thin diaphragm area between the protrusions prior to and during insertion of the probe. After extraction of the probe, the protrusions are allowed to return to a relaxed state, which discontinues stretching of the diaphragm area and reseals the container.
A pierceable self-resealing stopper for a container is disclosed. The disclosed stopper is suitable for sealing a container containing reagents for use in a high-throughput analysis system in which reagents in the container are accessed by an aspirator probe piercing the stopper. The stopper is configured for being pierced and resealing itself a large number of times without degradation of the stopper by coring or fragmentation, for example. A set of protrusions extending from a top surface of the stopper is depressed to stretch a thin diaphragm area between the protrusions prior to and during insertion of the probe. After extraction of the probe, the protrusions are allowed to return to a relaxed state, which discontinues stretching of the diaphragm area and reseals the container.
B65D 81/00 - Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
G01N 1/38 - Diluting, dispersing or mixing samples
B65D 81/32 - Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
An apparatus for measuring blood clotting time includes a blood clot detection instrument and a cuvette for use with the blood clot detection instrument. The cuvette includes a blood sample receptor-inlet; a channel arrangement including at least one test channel for performing a blood clotting time measurement, a sampling channel having at least one surface portion that is hydrophilic, communicating with the blood sample receptor-inlet and the at least one test channel, and a waste channel having at least one surface portion that is hydrophilic, communicating with the sampling channel; and a vent opening communicating with the sampling channel. The sampling channel, the vent opening and the waste channel, coact to automatically draw a requisite volume of a blood sample deposited at the blood receptor-inlet, into the sampling channel. More specifically, air compressed within the blood clot detection instrument, the at least one test channel of the cuvette, and the section of the sampling channel extending beyond the vent opening of the cuvette, coacts with the waste channel to cause a leading edge of the blood sample drawn into the sampling channel from the blood receptor-inlet, to pull back within the sampling channel and uncover an optical sensor in of the blood clot detection instrument. The uncovering of the optical sensor activates a pump module of the blood clot detection instrument, which draws the requisite volume of the blood sample into the at least one test channel.
A fluid aspiration probe apparatus for automatic fluid testing equipment includes a pair of electrodes mounted on a distal probe tip. The electrodes are coupled to an impedance measurement apparatus via conductive pathways along the probe. The impedance measurements and probe tip height are monitored as the probe tip is lowered into a fluid sample. Boundaries between layers of fluid in the container are detected by recognizing sudden changes in the impedance measurements and heights of the boundaries are determined by tracking the position of probe tip when the sudden changes of impedance occur.
A fluid aspiration probe apparatus for automatic fluid testing equipment includes a pair of electrodes mounted on a distal probe tip. The electrodes are coupled to an impedance measurement apparatus via conductive pathways along the probe. The impedance measurements and probe tip height are monitored as the probe tip is lowered into a fluid sample. Boundaries between layers of fluid in the container are detected by recognizing sudden changes in the impedance measurements and heights of the boundaries are determined by tracking the position of probe tip when the sudden changes of impedance occur.
G01F 23/24 - Indicating or measuring liquid level or level of fluent solid material, e.g. indicating in terms of volume or indicating by means of an alarm by measuring physical variables, other than linear dimensions, pressure or weight, dependent on the level to be measured, e.g. by difference of heat transfer of steam or water by measuring variations of resistance of resistors due to contact with conductor fluid
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
G01N 15/05 - Investigating sedimentation of particle suspensions in blood
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
A disposable hemolysis sensor module (100) is described. The module comprises a flow cell (104) for housing a column of whole blood, an acoustic transducer (106) for generating acoustic forces on said flow cell for temporarily partitioning the whole blood in the flow cell into a first region comprising cell free plasma and a second region comprising blood cells, a light source (108), such as a light source comprising red LED and a yellow LED, for illuminating the cell free plasma in the first region, one or more optical imaging sensors (110), such as a camera, for acquiring one or more digital images of the cell free plasma in the first region while said cell free plasma is illuminated by said light source, and a housing (112) configured for removable installation in an instrument cartridge of a blood analysis instrument, wherein the housing is further configured to locate the flow cell, the light source and the optical imaging sensors in fixed alignment relative to each other.
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
An apparatus for measuring hemolysis in a cartridge based automated blood analyzer is described. The apparatus allows hemolysis testing to be performed on a sample which is presented as a whole blood sample for other testing by the cartridge based automated blood analyzer. A disposable module is configured for optically analyzing one or more plasma analytes in a flow cell while red blood cells are acoustically separated from plasma in the flow cell.
Described is an automated reagent dispensing cap and methods of use in an automated clinical analyzer for introducing one or more reagent components housed in the reagent dispensing cap into a container enclosing another reagent component with which it is combined to achieve a reagent useful for diagnostic testing.
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
B65D 39/08 - Threaded or like closure members secured by rotationBushes therefor
B65D 51/28 - Closures not otherwise provided for combined with auxiliary devices for non-closing purposes with auxiliary containers for additional articles or materials
B65D 81/32 - Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
G01N 35/10 - Devices for transferring samples to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
(1) Hemostasis laboratory automation systems, namely, data management and laboratory computer hardware; data management and laboratory automation systems comprised of computer hardware and software for use in the fields of hemostasis and medical diagnostics; laboratory equipment for use in the field of clinical research diagnostics, namely automation equipment consisting of robots, automated conveyor systems, sample decappers, sample recappers, racks, drawers, sorting trays, barcode scanners, centrifuges, machine vision, and computer hardware and software to automate the sorting and analysis of laboratory samples and tubes, online storage of medical and biological data relating to medical samples, sample transport, centrifugation, sample resealing and desealing, and aliquoting; data management and laboratory computer hardware; data management and laboratory automation systems comprised of computer hardware and software for use in the fields of medical diagnostics and hemostasis
(2) Hemostasis laboratory automation systems and parts therefor, namely, medical apparatus for diagnostic testing in the field of hemostasis; laboratory equipment for use in the fields of hemostasis and medical diagnostics, namely, automation equipment consisting of robots, conveyor systems, machine vision, and computer hardware and software to automate the sorting of laboratory samples and tubes and aliquoting for medical diagnostic use; apparatus and instruments for transferring and sorting blood collecting tubes and sample tubes or containers for samples, all for medical use; medical sample tube sorting apparatus; sample container transfer apparatus for medical purposes; sample rack transfer apparatus for medical purposes; laboratory automation systems for use in the field of hemostasis analysis and medical diagnostics Laboratory equipment for use in the fields of hemostasis and medical diagnostics, namely, automation equipment consisting of robots, conveyor systems, machine vision, and computer hardware and software to automate the sorting of laboratory samples and tubes and aliquoting for medical diagnostic use; diagnostic instruments for medical use, namely, automated coagulation analyzers for measuring clotting characteristics and clotting constituents in blood; hemostasis laboratory automation systems comprised of medical diagnostic instruments for the analysis of body fluids and related data management computer software and hardware sold as a unit, and structural parts therefor
96.
Optical flow cell apparatus and method for reducing deflection of sample chamber
A sample cell apparatus for use in spectroscopic determination of an analyte in a body fluid sample includes a first plate member and a second plate member made from an optically clear material. A channel extending into a surface of the first plate member and an opposing surface of the second plate member houses a floating seal, which surrounds a fluid sample chamber. The fluid chamber is closed to define a repeatable optical path-length therethrough by urging the first plate member against the second plate member without compressing the floating seal between the first plate member and the second plate member. The seal channel is vented to prevent fluid pressure from flexing the first plate member or the second plate member. An actuator having an extended foot portion extends over the fluid chamber to help prevent flexing of the first plate member or the second plate member.
G01N 21/31 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
An optical system and method for quantifying total protein in whole blood or other multi-phase liquids and colloidal suspensions uses refractometry without preliminary steps such as cell separation or centrifugation. A refractometer is integrated with a flow cell to enable the refractive index of a flowing sample to be measured based on a substantially cell free boundary layer of the sample that is present under certain flow conditions. Dimensions of the flow cell are selected to produce a cell-free layer in a flow of whole blood in which the cell free layer is thick enough to reduce scattering of light from the refractometer light source. A numerical method is used to compensate for scattering artifacts. The numerical compensation method is based on the slope and width of a peak in the derivative curve of an angular spectrum image of the flowing sample produced by refractometry.
G01N 21/41 - RefractivityPhase-affecting properties, e.g. optical path length
G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
Analyte content in a cell free portion of a body fluid, such as blood, is optically determined without centrifugation or other preliminary steps for separating the cell free portion from the body fluid. A channel is configured for containing a flowing sample of the body fluid along an optical boundary. The channel is configured so that a cell free layer of the fluid naturally forms along the boundary of the channel which coincides with the optical boundary. A light source is directed onto the optical boundary at an angle selected to generate total reflection from the boundary and to generate an evanescent field across the boundary in the cell free layer of fluid. A light detector is configured to detect absorption of the light in the evanescent field. The light source and light detector are matched to the wavelength range of an absorption peak of the analyte being detected.
An apparatus for measuring blood clotting time includes a blood clot detection instrument and a cuvette for use with the blood clot detection instrument. The cuvette includes a blood sample receptor-inlet; a channel arrangement including at least one test channel for performing a blood clotting time measurement, a sampling channel having at least one surface portion that is hydrophilic, communicating with the blood sample receptor-inlet and the at least one test channel, and a waste channel having at least one surface portion that is hydrophilic, communicating with the sampling channel; and a vent opening communicating with the sampling channel. The sampling channel, the vent opening and the waste channel, coact to automatically draw a requisite volume of a blood sample deposited at the blood receptor-inlet, into the sampling channel. More specifically, air compressed within the blood clot detection instrument, the at least one test channel of the cuvette, and the section of the sampling channel extending beyond the vent opening of the cuvette, coacts with the waste channel to cause a leading edge of the blood sample drawn into the sampling channel from the blood receptor-inlet, to pull back within the sampling channel and uncover an optical sensor in of the blood clot detection instrument. The uncovering of the optical sensor activates a pump module of the blood clot detection instrument, which draws the requisite volume of the blood sample into the at least one test channel.
An optical system and method for quantifying total protein in whole blood or other multi-phase liquids and colloidal suspensions uses refractometry without preliminary steps such as cell separation or centrifugation. A refractometer is integrated with a flow cell to enable the refractive index of a flowing sample to be measured based on a substantially cell free boundary layer of the sample that is present under certain flow conditions. Dimensions of the flow cell are selected to produce a cell-free layer in a flow of whole blood in which the cell free layer is thick enough to reduce scattering of light from the refractometer light source. A numerical method is used to compensate for scattering artifacts. The numerical compensation method is based on the slope and width of a peak in the derivative curve of an angular spectrum image of the flowing sample produced by refractometry.
G01N 21/41 - RefractivityPhase-affecting properties, e.g. optical path length
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
G01N 21/27 - ColourSpectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands using photo-electric detection
