Systems and methods for delivering a therapeutic agent to target tissue using a plurality of drug delivery platforms each having the therapeutic drug embedded as part of the drug delivery platform. Each drug delivery platform is implanted into a target tissue, and the active agent elutes out of the drug delivery platform for a target period of time, delivering a therapeutic dose of the drug for that period of time. The duration of therapy for an implant can be from 3 to 12 months, longer, or shorter.
A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A nasal stent includes an elongated tubular body having proximal and distal ends extending along a longitudinal axis. The elongated body includes a repeating pattern of W-shaped members extending around the tubular body separated by longitudinally-oriented and offset struts. The elongated tubular body is selectively transitionable between an expanded configuration and a crimped configuration, wherein the pattern of W-shaped members and struts interleave allowing the elongated tubular body to maintain substantially the same length when disposed in the expanded configuration and the crimped configuration.
A61F 2/915 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
A61F 2/958 - Inflatable balloons for placing stents or stent-grafts
A nasal stent includes an elongated tubular body having proximal and distal ends extending along a longitudinal axis. The elongated body includes a repeating pattern of W-shaped members extending around the tubular body separated by longitudinally-oriented and offset struts. The elongated tubular body is selectively transitionable between an expanded configuration and a crimped configuration, wherein the pattern of W-shaped members and struts interleave allowing the elongated tubular body to maintain substantially the same length when disposed in the expanded configuration and the crimped configuration.
A61F 2/915 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
Described here are delivery devices for delivering one or more implants to the body, and methods of using. The delivery devices may deliver implants to a variety of locations within the body, for a number of different uses. In some variations, the delivery devices have a cannula with one or more curved sections. In some variations, a pusher may be used to release one or more implants from the cannula. In some variations, one or more of the released implants may be a self-expanding device. Methods of delivering implants to one or more sinus cavities are also described here.
A61F 2/89 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
A61L 31/16 - Biologically active materials, e.g. therapeutic substances
A61F 2/04 - Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
A61F 2/18 - Internal ear or nose parts, e.g. ear-drums
Described here are systems, devices, and methods for delivery of an implant to a bodily cavity. The implant may include a hub and a plurality of legs, and may be moveable between a low-profile and expanded configuration. The systems may include a crimping device having a crimping member with a plurality of arms. The plurality of arms may engage the plurality of legs of the implant, and may move the legs to move the implant to the low-profile configuration. In some instances a delivery device may aid in crimping and/or delivery of the implant.
Described here are expandable devices and methods for using them. The devices generally comprise a hub and a plurality of legs extending therefrom. In some variations, the hub may comprise one or more domed portions, tapered portions, or the like. The legs may comprise one or more straight segments, one or more curved segments, or a combination thereof. The devices may comprise one or more polymers, and/or one or more portions of the device may be configured to biodegrade. In other variations, the device may be configured to release one or more drugs therefrom. Additionally, in some variations the devices may be configured to be self-expandable from a low-profile configuration to an expanded configuration.
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Providing a website featuring information in the field of sinusitis and medical devices and pharmaceuticals for the treatment of ear, nose, throat, sinus and respiratory-related conditions and symptoms
Described here are systems and methods for delivering an active agent to target tissues of the ear, nose, or throat using a drug delivery platform having the therapeutic drug embedded as part of the drug delivery platform. The drug delivery platform is implanted into a target tissue, and the active agent elutes out of the body of the drug delivery platform for a target period of time, delivering a therapeutic dose of the drug for that period of time. The duration of therapy for an implant into a sinus tissue can be from 3 to 12 months, or longer, thereby providing relief for the full duration of an allergy season. Moreover, the duration of therapy can provide relief to individuals with chronic paranasal sinus condition symptoms for a period of time longer than presently available therapies, thus allowing for only semi-annual or annual applications of the therapy.
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Described here are delivery devices for delivering one or more implants to the body, and methods of using. The delivery devices may deliver implants to a variety of locations within the body, for a number of different uses. In some variations, the delivery devices have a cannula with one or more curved sections. In some variations, a pusher may be used to release one or more implants from the cannula. In some variations, one or more of the released implants may be a self-expanding device. Methods of delivering implants to one or more sinus cavities are also described here.
A61F 2/89 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
A61L 31/16 - Biologically active materials, e.g. therapeutic substances
A61F 2/04 - Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61M 29/00 - Dilators with or without means for introducing media, e.g. remedies
A61F 2/915 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
Systems and methods for delivering a therapeutic agent to target tissue using a plurality of drug delivery platforms each having a polymer scaffold and the therapeutic agent contained within the polymer scaffold. Each drug delivery platform of the plurality of drug delivery platforms is implanted into the target tissue, allowing the therapeutic agent to elute from each drug delivery platform of the plurality of drug delivery platforms for a target period of time, delivering a therapeutic dose of the therapeutic agent for the target period of time. Each drug delivery platform of the plurality of drug delivery platforms is allowed to biodegrade within the target tissue.
A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
Described here are systems and methods for delivering an active agent to target tissues of the ear, nose, or throat using a drug delivery platform having the therapeutic drug embedded as part of the drug delivery platform. The drug delivery platform is implanted into a target tissue, and the active agent elutes out of the body of the drug delivery platform for a target period of time, delivering a therapeutic dose of the drug for that period of time. The duration of therapy for an implant into a sinus tissue can be from 3 to 12 months, or longer, thereby providing relief for the full duration of an allergy season. Moreover, the duration of therapy can provide relief to individuals with chronic paranasal sinus condition symptoms for a period of time longer than presently available therapies, thus allowing for only semi-annual or annual applications of the therapy.
Described here are delivery devices for delivering one or more implants to the body, and methods of using. The delivery devices may deliver implants to a variety of locations within the body, for a number of different uses. In some variations, the delivery devices have a cannula with one or more curved sections. In some variations, a pusher may be used to release one or more implants from the cannula. In some variations, one or more of the released implants may be a self-expanding device. Methods of delivering implants to one or more sinus cavities are also described here.
A61F 2/89 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
A61L 31/16 - Biologically active materials, e.g. therapeutic substances
A61F 2/04 - Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61M 29/00 - Dilators with or without means for introducing media, e.g. remedies
A61F 2/915 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
Described here are devices, systems, and methods for treating conditions or diseases of the nose, ear, or throat with an expandable device having a drug coating. The expandable devices may be delivered to a body cavity in a low-profile configuration and expanded to contact surrounding tissue. The expandable devices may deliver or release the drug coating to the tissue. Multiple expansions of a single device may be employed during treatment. Various coating excipients and manufacturing parameters for the expandable devices may also be adjusted to enhance or slow transfer of the drug coating and/or release of the drug to the target tissue site. The drug transferred to the tissue may act as an in situ depot that enables maintenance of a therapeutic level of locally delivered drug for a desired time period after removal of the expandable devices.
Described here are systems and methods for delivering an active agent to target tissues of the ear, nose, or throat using an expandable member having drug crystals layered thereon, and methods for manufacturing such systems. The expandable member can be delivered to the target tissues in a low-profile configuration and expanded to contact and/or dilate surrounding tissue. Expansion of the expandable member transfers the drug crystals to the target tissues, which then act as an in situ depot that enables maintenance of a therapeutic level of an active agent for a desired time period after removal of the expandable member. Multiple expansions of a single expandable member can be employed during treatment. For example, the systems and methods can be useful when it is desired to treat multiple paranasal sinuses with a single expandable member.
A61L 29/06 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A61L 29/16 - Biologically active materials, e.g. therapeutic substances
A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
15.
EXPANDABLE MEMBER SYSTEMS AND METHODS FOR DRUG DELIVERY
Described here are systems and methods for delivering an active agent to target tissues of the ear, nose, or throat using an expandable member having drug crystals layered thereon, and methods for manufacturing such systems. The expandable member can be delivered to the target tissues in a low-profile configuration and expanded to contact and/or dilate surrounding tissue. Expansion of the expandable member transfers the drug crystals to the target tissues, which then act as an in situ depot that enables maintenance of a therapeutic level of an active agent for a desired time period after removal of the expandable member. Multiple expansions of a single expandable member can be employed during treatment. For example, the systems and methods can be useful when it is desired to treat multiple paranasal sinuses with a single expandable member.
Described here are delivery devices for delivering one or more implants to the body, and methods of using. The delivery devices may deliver implants to a variety of locations within the body, for a number of different uses. In some variations, the delivery devices have a cannula with one or more curved sections. In some variations, a pusher may be used to release one or more implants from the cannula. In some variations, one or more of the released implants may be a self-expanding device. Methods of delivering implants to one or more sinus cavities are also described here.
A61F 2/89 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
A61L 31/16 - Biologically active materials, e.g. therapeutic substances
A61F 2/04 - Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
A61F 2/18 - Internal ear or nose parts, e.g. ear-drums
A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61M 29/00 - Dilators with or without means for introducing media, e.g. remedies
A61F 2/915 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
Described here are devices, systems, and methods for treating conditions or diseases of the nose, ear, or throat with an expandable device having a drug coating. The expandable devices may be delivered to a body cavity in a low-profile configuration and expanded to contact surrounding tissue. The expandable devices may deliver or release the drug coating to the tissue. Multiple expansions of a single device may be employed during treatment. Various coating excipients and manufacturing parameters for the expandable devices may also be adjusted to enhance or slow transfer of the drug coating and/or release of the drug to the target tissue site. The drug transferred to the tissue may act as an in situ depot that enables maintenance of a therapeutic level of locally delivered drug for a desired time period after removal of the expandable devices.
Described here are delivery devices for delivering one or more implants to the body, and methods of using. The delivery devices may deliver implants to a variety of locations within the body, for a number of different uses. In some variations, the delivery devices have a cannula with one or more curved sections. In some variations, a pusher may be used to release one or more implants from the cannula. In some variations, one or more of the released implants may be a self-expanding device. Methods of delivering implants to one or more sinus cavities are also described here.
A61F 2/89 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
A61L 31/16 - Biologically active materials, e.g. therapeutic substances
A61F 2/04 - Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
A61F 2/18 - Internal ear or nose parts, e.g. ear-drums
A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61M 29/00 - Dilators with or without means for introducing media, e.g. remedies
A61F 2/915 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
Described here are devices, systems, and methods for treating conditions or diseases of the nose, ear, or throat with an expandable device having a drug coating. The expandable devices may be delivered to a body cavity in a low-profile configuration and expanded to contact surrounding tissue. The expandable devices may deliver or release the drug coating to the tissue. Multiple expansions of a single device may be employed during treatment. Various coating excipients and manufacturing parameters for the expandable devices may also be adjusted to enhance or slow transfer of the drug coating and/or release of the drug to the target tissue site. The drug transferred to the tissue may act as an in situ depot that enables maintenance of a therapeutic level of locally delivered drug for a desired time period after removal of the expandable devices.
This application is generally related to systems and methods for accessing the paranasal sinuses and other passages of the nose, ear, and throat. The systems and methods generally employ devices capable of maintaining a fixed handle orientation with respect to the patient while generating the appropriate applicator deflection angle required to rotationally align or orient the applicator tip to the intended target tissue/anatomy for treatment. Methods are also described for deploying drug delivery devices within these body structures using the systems to treat medical conditions associated therewith.
Described here are systems, devices, and methods for delivery of an implant to a bodily cavity. The implant may include a hub and a plurality of legs, and may be moveable between a low-profile and expanded configuration. The systems may include a crimping device having a crimping member with a plurality of arms. The plurality of arms may engage the plurality of legs of the implant, and may move the legs to move the implant to the low-profile configuration. In some instances a delivery device may aid in crimping and/or delivery of the implant.
Described here are expandable devices and methods for using them. The devices generally comprise a hub and a plurality of legs extending therefrom. In some variations, the hub may comprise one or more domed portions, tapered portions, or the like. The legs may comprise one or more straight segments, one or more curved segments, or a combination thereof. The devices may comprise one or more polymers, and/or one or more portions of the device may be configured to biodegrade. In other variations, the device may be configured to release one or more drugs therefrom. Additionally, in some variations the devices may be configured to be self-expandable from a low-profile configuration to an expanded configuration.
Described here are delivery devices for delivering one or more implants to the body, and methods of using. The delivery devices may deliver implants to a variety of locations within the body, for a number of different uses. In some variations, the delivery devices have a cannula with one or more curved sections. In some variations, a pusher may be used to release one or more implants from the cannula. In some variations, one or more of the released implants may be a self-expanding device. Methods of delivering implants to one or more sinus cavities are also described here.
A61L 31/16 - Biologically active materials, e.g. therapeutic substances
A61F 2/89 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
A61F 2/04 - Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61M 29/00 - Dilators with or without means for introducing media, e.g. remedies
A61B 17/24 - Surgical instruments, devices or methods for use in the oral cavity, larynx, bronchial passages or noseTongue scrapers
A61F 2/915 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
Medical devices consisting of artificial materials for the
treatment of nose and sinus and respiratory-related
conditions and symptoms, namely, implants comprised of
drug-eluting stents; drug delivery systems; surgical devices
and instruments for the treatment of nose and sinus and
respiratory-related conditions and symptoms.
(1) Medical devices consisting of artificial materials for the treatment of nose and sinus and respiratory-related conditions and symptoms, namely, implants comprised of drug-eluting stents; drug delivery systems, namely, dissolvable implants for a sustained drug delivery and localized release of pharmaceutical preparations for the treatment of anti-inflammation of sinuses and sinus linings post-surgery; surgical devices, namely, medical stents and surgical instruments for the treatment of nose and sinus and respiratory-related conditions and symptoms and instruments for the treatment of nose and sinus and respiratory-related conditions and symptoms.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceuticals for the treatment of nose and sinus and
respiratory-related conditions and symptoms. Medical devices consisting of artificial materials for the
treatment of nose and sinus and respiratory-related
conditions and symptoms, namely, implants comprised of
drug-eluting stents; drug delivery systems; surgical devices
and instruments for the treatment of nose and sinus and
respiratory-related conditions and symptoms.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
(1) Pharmaceuticals for the treatment of nose and sinus and respiratory-related conditions and symptoms.
(2) Medical devices consisting of artificial materials for the treatment of nose and sinus and respiratory-related conditions and symptoms, namely, implants comprised of drug-eluting stents; drug delivery systems; surgical devices and instruments for the treatment of nose and sinus and respiratory-related conditions and symptoms.
Medical devices consisting of artificial materials for the treatment of nose and sinus and respiratory-related conditions and symptoms, namely, implants comprised of drug-eluting stents; drug delivery systems; surgical devices and instruments for the treatment of nose and sinus and respiratory-related conditions and symptoms
Medical devices consisting of artificial materials for the treatment of nose and sinus and respiratory-related conditions and symptoms, namely, implants comprised of drug-eluting stents; drug delivery systems; surgical devices and instruments for the treatment of nose and sinus and respiratory-related conditions and symptoms
Medical devices consisting of artificial materials for the treatment of nose and sinus and respiratory-related conditions and symptoms, namely, implants comprised of drug-eluting stents; drug delivery systems; surgical devices and instruments for the treatment of nose and sinus and respiratory-related conditions and symptoms
Described here are devices, systems, and methods for treating conditions or diseases of the nose, ear, or throat with an expandable device having a drug coating. The expandable devices may be delivered to a body cavity in a low-profile configuration and expanded to contact surrounding tissue. The expandable devices may deliver or release the drug coating to the tissue. Multiple expansions of a single device may be employed during treatment. Various coating excipients and manufacturing parameters for the expandable devices may also be adjusted to enhance or slow transfer of the drug coating and/or release of the drug to the target tissue site. The drug transferred to the tissue may act as an in situ depot that enables maintenance of a therapeutic level of locally delivered drug for a desired time period after removal of the expandable devices.
Described here are devices, systems, and methods for treating conditions or diseases of the nose, ear, or throat with an expandable device having a drug coating. The expandable devices may be delivered to a body cavity in a low-profile configuration and expanded to contact surrounding tissue. The expandable devices may deliver or release the drug coating to the tissue. Multiple expansions of a single device may be employed during treatment. Various coating excipients and manufacturing parameters for the expandable devices may also be adjusted to enhance or slow transfer of the drug coating and/or release of the drug to the target tissue site. The drug transferred to the tissue may act as an in situ depot that enables maintenance of a therapeutic level of locally delivered drug for a desired time period after removal of the expandable devices.
05 - Pharmaceutical, veterinary and sanitary products
10 - Medical apparatus and instruments
Goods & Services
Pharmaceuticals for the treatment of nose and sinus and respiratory-related conditions and symptoms Medical devices consisting of artificial materials for the treatment of nose and sinus and respiratory-related conditions and symptoms, namely, implants comprised of drug-eluting stents; drug delivery systems; surgical devices and instruments for the treatment of nose and sinus and respiratory-related conditions and symptoms
34.
Systems, devices, and method for treating a sinus condition
Described here are systems, devices, and methods for delivery of an implant to a bodily cavity. The implant may include a hub and a plurality of legs, and may be moveable between a low-profile and expanded configuration. The systems may include a crimping device having a crimping member with a plurality of arms. The plurality of arms may engage the plurality of legs of the implant, and may move the legs to move the implant to the low-profile configuration. In some instances a delivery device may aid in crimping and/or delivery of the implant.
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
A website providing information in the field of sinusitis and medical devices and/or pharmaceuticals for the treatment of ear, nose, throat, sinus and respiratory-related conditions and symptoms
Medical devices consisting of artificial materials for the
treatment of nose and sinus and respiratory-related
conditions and symptoms, namely, implants comprised of
drug-eluting stents; drug delivery systems; surgical devices
and instruments for the treatment of nose and sinus and
respiratory-related conditions and symptoms.
37.
SYSTEMS, DEVICES, AND METHOD FOR TREATING A SINUS CONDITION
Described here are systems, devices, and methods for delivery of an implant to a bodily cavity. The implant may include a hub and a plurality of legs, and may be moveable between a low-profile and expanded configuration. The systems may include a crimping device having a crimping member with a plurality of arms. The plurality of arms may engage the plurality of legs of the implant, and may move the legs to move the implant to the low-profile configuration In some instances a delivery device may aid in crimping and/or delivery of the implant.
Described here are systems, devices, and methods for delivery of an implant to a bodily cavity. The implant may include a hub and a plurality of legs, and may be moveable between a low-profile and expanded configuration. The systems may include a crimping device having a crimping member with a plurality of arms. The plurality of arms may engage the plurality of legs of the implant, and may move the legs to move the implant to the low-profile configuration In some instances a delivery device may aid in crimping and/or delivery of the implant.
Described here are devices and methods for crimping self-expanding devices. The crimping devices may be useful for crimping a variety of different self-expanding devices (whether such devices are biodegradable or bio-durable). The crimping devices may have crimping members to engage the self-expanding device to reduce the device from an expanding configuration to an unexpanded configuration. The crimping member may comprise or include a suture, wire, ribbon, guiding hoop, pusher, prong, holding bar, balloon, jaws, combinations thereof, or the like. The crimping devices may also include or comprise a holding structure to hold the self-expanding device in an unexpanded or expanded configuration.
B23P 19/00 - Machines for simply fitting together or separating metal parts or objects, or metal and non-metal parts, whether or not involving some deformationTools or devices therefor so far as not provided for in other classes
A61F 2/95 - Instruments specially adapted for placement or removal of stents or stent-grafts
B25B 27/10 - Hand tools or bench devices, specially adapted for fitting together or separating parts or objects whether or not involving some deformation, not otherwise provided for for connecting objects by press fit or detaching same inserting fittings into hoses
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
Systems, devices, and methods may be used for delivery of an implant to a bodily cavity. The implant may include a hub and a plurality of legs, and may be moveable between a low-profile and expanded configuration. The systems may include a crimping device having a crimping member with a plurality of arms. The plurality of arms may engage the plurality of legs of the implant, and may move the legs to move the implant to the low-profile configuration. In some instances a delivery device may aid in crimping and/or delivery of the implant.
Described here are delivery devices for delivering one or more implants to the body, and methods of using. The delivery devices may deliver implants to a variety of locations within the body, for a number of different uses. In some variations, the delivery devices have a cannula with one or more curved sections. In some variations, a pusher may be used to release one or more implants from the cannula. In some variations, one or more of the released implants may be a self-expanding device. Methods of delivering implants to one or more sinus cavities are also described here.
A61F 2/86 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure
A61F 2/95 - Instruments specially adapted for placement or removal of stents or stent-grafts
A61F 5/08 - Devices for correcting deformities of the nose
A61L 31/14 - Materials characterised by their function or physical properties
A61L 31/16 - Biologically active materials, e.g. therapeutic substances
A61F 2/89 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
A61F 2/18 - Internal ear or nose parts, e.g. ear-drums
A61F 2/915 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheets or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
Described here are self-expanding devices and methods of using and making them. The devices may be useful in a variety of locations within the body, for a number of different uses. In some variations, the devices have a first compressed configuration enabling low profile delivery through a delivery device, a second expanded configuration for apposition against tissue, and comprise either a single continuous filament or at least two non-intersecting filaments. In some variations, the device is formed into a shape having a series of peaks and valleys. At least one of the peaks and valleys may have a loop at then end thereof. At least a portion of these devices may be capable of biodegrading over a predetermined period of time, and the devices may be configured for drug delivery. Methods of treating one or more sinus cavities are also described here.
A61F 2/86 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure
A61F 5/08 - Devices for correcting deformities of the nose
A61L 31/14 - Materials characterised by their function or physical properties
A61L 31/16 - Biologically active materials, e.g. therapeutic substances
A61F 2/89 - Stents in a form characterised by wire-like elementsStents in a form characterised by a net-like or mesh-like structure the wire-like elements comprising two or more adjacent rings flexibly connected by separate members
A61F 2/04 - Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
A61F 2/18 - Internal ear or nose parts, e.g. ear-drums
Medical devices consisting of artificial materials for the
treatment of nose and sinus and respiratory-related
conditions and symptoms, namely, implants comprised of
drug-eluting stents; drug delivery systems; surgical devices
and instruments for the treatment of nose and sinus and
respiratory-related conditions and symptoms.
(1) Medical devices consisting of artificial materials for the treatment of nose and sinus and respiratory-related conditions and symptoms, namely, implants comprised of drug-eluting stents; drug delivery systems, namely, controlled timed release and/or targeted release pharmaceutical preparations for the treatment of nose and sinus and respiratory-related conditions and symptoms; surgical instruments for the treatment of nose and sinus and respiratory-related conditions and symptoms.
Medical devices consisting of artificial materials for the
treatment of nose and sinus and respiratory-related
conditions and symptoms, namely, implants comprised of
drug-eluting stents; drug delivery systems; surgical devices
and instruments for the treatment of nose and sinus and
respiratory-related conditions and symptoms.
Medical devices consisting of artificial materials for the treatment of nose and sinus and respiratory-related conditions and symptoms, namely, implants comprised of drug-eluting stents; drug delivery systems; surgical devices and instruments for the treatment of nose and sinus and respiratory-related conditions and symptoms
47.
Expandable devices and methods for treating a nasal or sinus condition
Described here are expandable devices and methods for using them. The devices generally comprise a hub and a plurality of legs extending therefrom. In some variations, the hub may comprise one or more domed portions, tapered portions, or the like. The legs may comprise one or more straight segments, one or more curved segments, or a combination thereof. The devices may comprise one or more polymers, and/or one or more portions of the device may be configured to biodegrade. In other variations, the device may be configured to release one or more drugs therefrom. Additionally, in some variations the devices may be configured to be self-expandable from a low-profile configuration to an expanded configuration.
Described here are devices and methods for treating one or more conditions or symptoms associated with a tonsil procedure. In some variations, a drug-releasing device may be at least partially delivered to one or more tonsillar tissues before, during, or after a tonsil procedure. In some variations, the drug-releasing device may be configured to be biodegradable. In other variations, the drug-releasing device may comprise one or more hemostatic materials or one or more adhesives. The drug-releasing device may be configured to release one or more drugs or agents, such as, for example, one or more analgesics, local anesthetics, vasoconstrictors, antibiotics, combinations thereof and the like.
Described here are expandable devicesand methods for using them. The devices generally comprise a hub and a plurality of legs extending therefrom. In some variations, the hub may comprise one or more domed portions, taperedportions, or the like. The legs may comprise one or more straight segments, one or more curved segments, or a combination thereof. The devices may comprise one or more polymers, and/ or one or more portions of the device may be configured to biodegrade. In other variations, the devicemay be configured to release one or more drugs therefrom. Additionally, in some variations the devices may be configured to be self-expandablefrom a low-profile configuration to an expandedconfiguration.
Described here are expandable devices and methods for using them. The devices generally comprise a hub and a plurality of legs extending therefrom. In some variations, the hub may comprise one or more domed portions, tapered portions, or the like. The legs may comprise one or more straight segments, one or more curved segments, or a combination thereof. The devices may comprise one or more polymers, and/or one or more portions of the device may be configured to biodegrade. In other variations, the device may be configured to release one or more drugs therefrom. Additionally, in some variations the devices may be configured to be self-expandable from a low-profile configuration to an expanded configuration.
Described here are devices and methods for treating one or more conditions or symptoms associated with a tonsil procedure. In some variations, a drug-releasing device may be at least partially delivered to one or more tonsillar tissues before, during, or after a tonsil procedure. In some variations, the drug-releasing device may be configured to be biodegradable. In other variations, the drug-releasing device may comprise one or more hemostatic materials or one or more adhesives. The drug-releasing device may be configured to release one or more drugs or agents, such as, for example, one or more analgesics, local anesthetics, vasoconstrictors, antibiotics, combinations thereof and the like.
Described here are devices and methods for dilating tissues. In other variations, the dilatation device comprises a slotted or expandable tube that may expand to dilate tissue. In still other variations, the dilatation device comprises two or more hinged or movable plate members that separate to dilate tissue. In yet other variations, the dilation device may comprise one or more flexible members. One or more portions of the dilatation device may be detachable from the device in the body, and dilatation device may release one or more implants into the body. In some of these variations, the dilatation device may additionally be used to expand one or more implants or other devices within the body. In some variations the dilatation device may release one or more substances that may hold dilated tissue in a dilated configuration.
Described here are devices and methods for dilating tissues. In other variations, the dilatation device comprises a slotted or expandable tube that may expand to dilate tissue. In still other variations, the dilatation device comprises two or more hinged or movable plate members that separate to dilate tissue. In yet other variations, the dilation device may comprise one or more flexible members. One or more portions of the dilatation device may be detachable from the device in the body, and dilatation device may release one or more implants into the body. In some of these variations, the dilatation device may additionally be used to expand one or more implants or other devices within the body. In some variations the dilatation device may release one or more substances that may hold dilated tissue in a dilated configuration.
Medical devices consisting of artificial materials for the
treatment of ear, nose, throat, sinus and
respiratory-related conditions and symptoms, namely
implants; drug delivery systems; surgical devices and
instruments.
55.
Methods and devices for crimping self-expanding devices
Described here are devices and methods for crimping self-expanding devices. The crimping devices may be useful for crimping a variety of different self-expanding devices (whether such devices are biodegradable or bio-durable). The crimping devices may have crimping members to engage the self-expanding device to reduce the device from an expanding configuration to an unexpanded configuration. The crimping member may comprise or include a suture, wire, ribbon, guiding hoop, pusher, prong, holding bar, balloon, jaws, combinations thereof, or the like. The crimping devices may also include or comprise a holding structure to hold the self-expanding device in an unexpanded or expanded configuration.
B23P 19/00 - Machines for simply fitting together or separating metal parts or objects, or metal and non-metal parts, whether or not involving some deformationTools or devices therefor so far as not provided for in other classes
B25B 27/10 - Hand tools or bench devices, specially adapted for fitting together or separating parts or objects whether or not involving some deformation, not otherwise provided for for connecting objects by press fit or detaching same inserting fittings into hoses
A61F 2/95 - Instruments specially adapted for placement or removal of stents or stent-grafts
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
Described here are devices and methods for crimping self-expanding devices. The crimping devices may be useful for crimping a variety of different self-expanding devices (whether such devices are biodegradable or bio-durable). The crimping devices may have crimping members to engage the self-expanding device to reduce the device from an expanding configuration to an unexpanded configuration. The crimping member may comprise or include a suture, wire, ribbon, guiding hoop, pusher, prong, holding bar, balloon, jaws, combinations thereof, or the like. The crimping devices may also include or comprise a holding structure to hold the self-expanding device in an unexpanded or expanded configuration.
Medical devices consisting of artificial materials for the treatment of ear, nose, throat, sinus and respiratory-related conditions and symptoms, namely, implants; drug delivery systems; surgical devices and instruments
58.
Devices and methods for delivering active agents to the osteomeatal complex
Described here are devices, methods, and kits for treating sinusitis and related respiratory conditions by locally delivering active agents to the osteomeatal complex over a sustained period of time. The devices may be passively fixed within the osteomeatal complex and/or include one or more features that actively fix it within the osteomeatal complex. The devices may optionally include a portion that extends into a sinus ostium, sinus cavity, and/or the nasal passage to deliver an active agent.
Medical devices consisting of artificial materials for the treatment of ear, nose, throat, sinus and respiratory-related conditions and symptoms, namely, implants comprised of drug-eluting stents; drug delivery systems; surgical devices and instruments for the treatment of ear, nose, throat, sinus and respiratory-related conditions and symptoms
Medical devices consisting of artificial materials for the treatment of ear, nose, throat, sinus and respiratory-related conditions and symptoms, namely, implants comprised of drug-eluting stents; drug delivery systems; surgical devices and instruments for the treatment of ear, nose, throat, sinus and respiratory-related conditions and symptoms
A stent comprises a flexible tube having a proximal end, a distal end, and a passageway extending from said proximal end toward said distal end. A first generally straight tube segment extends from the proximal end while a first generally curved segment extends from an end region of the first generally straight tube segment disposed away from the proximal end of the stent. A second generally straight tube segment extends from an end region of the first curved segment away from the first generally straight tube segment and is arranged at an acute angle relative to the first generally straight tube segment. A second generally curved tube segment extends from one end of the second generally straight tube segment and includes a channel on an exterior surface of the second generally curved tube segment. The first generally curved tube segment and the second generally straight tube segment further include at least one cavity irrigation hole extending from the tube passageway, for providing irrigation fluids into the cavity into which the stent is inserted. At least one segments includes a channel on an exterior surface. The channel is sized to serve as a reservoir to contain a predetermined amount of at least one form of medication for delivery, over a period of time, of the medication to a cavity region proximate which the stent has been inserted.
A stent comprises a flexible tube having a proximal end, a distal end, and a passageway extending from said proximal end toward said distal end. A first generally straight tube segment extends from the proximal end while a first generally curved segment extends from an end region of the first generally straight tube segment disposed away from the proximal end of the stent. A second generally straight tube segment extends from an end region of the first curved segment away from the first generally straight tube segment and is arranged at an acute angle relative to the first generally straight tube segment. A second generally curved tube segment extends from one end of the second generally straight tube segment and includes a channel on an exterior surface of the second generally curved tube segment. The first generally curved tube segment and the second generally straight tube segment further include at least one cavity irrigation hole extending from the tube passageway, for providing irrigation fluids into the cavity into which the stent is inserted. At least one segments includes a channel on an exterior surface. The channel is sized to serve as a reservoir to contain a predetermined amount of at least one form of medication for delivery, over a period of time, of the medication to a cavity region proximate which the stent has been inserted.
Described here are paranasal sinus devices for treating paranasal sinus conditions. The devices include a cavity member, ostial member, and nasal portion. One or more of the cavity member, ostial member, and nasal portion may deliver an active agent for sustained release to treat the paranasal sinus condition. Exemplary paranasal sinus conditions are sinus inflammation due to functional endoscopic sinus surgery (FESS) and rhinosinusitis.
Described here are delivery devices for delivering one or more implants to the body, and methods of using. The delivery devices may deliver implants to a variety of locations within the body, for a number of different uses. In some variations, the delivery devices have a cannula with one or more curved sections. In some variations, a pusher may be used to release one or more implants from the cannula. In some variations, one or more of the released implants may be a self-expanding device. Methods of delivering implants to one or more sinus cavities are also described here.
Described here are self-expanding devices and methods of using and making them. The devices may be useful in a variety of locations within the body, for a number of different uses. In some variations, the devices have a first compressed configuration enabling low profile delivery through a delivery device, a second expanded configuration for apposition against tissue, and comprise either a single continuous filament or at least two non-intersecting filaments. In some variations, the device is formed into a shape having a series of peaks and valleys. At least one of the peaks and valleys may have a loop at then end thereof. At least a portion of these devices may be capable of biodegrading over a predetermined period of time, and the devices may be configured for drug delivery. Methods of treating one or more sinus cavities are also described here.
Described here are self-expanding devices and methods of using and making them. The devices may be useful in a variety of locations within the body, for a number of different uses. In some variations, the devices have a first compressed configuration enabling low profile delivery through a delivery device, a second expanded configuration for apposition against tissue, and comprise either a single continuous filament or at least two non-intersecting filaments. In some variations, the device is formed into a shape having a series of peaks and valleys. At least one of the peaks and valleys may have a loop at then end thereof. At least a portion of these devices may be capable of biodegrading over a predetermined period of time, and the devices may be configured for drug delivery. Methods of treating one or more sinus cavities are also described here.
Described here are self-expanding devices and methods of using and making them. The devices may be useful in a variety of locations within the body, for a number of different uses. In some variations, the devices have a first compressed configuration enabling low profile delivery through a delivery device, a second expanded configuration for apposition against tissue, and comprise either a single continuous filament or at least two non-intersecting filaments. In some variations, the device is formed into a shape having a series of peaks and valleys. At least one of the peaks and valleys may have a loop at then end thereof. At least a portion of these devices may be capable of biodegrading over a predetermined period of time, and the devices may be configured for drug delivery. Methods of treating one or more sinus cavities are also described here.
Described here are paranasal sinus devices for treating paranasal sinus conditions. The devices include a cavity member, ostial member, and nasal portion. One or more of the cavity member, ostial member, and nasal portion may deliver an active agent for sustained release to treat the paranasal sinus condition. Exemplary paranasal sinus conditions are sinus inflammation due to functional endoscopic sinus surgery (FESS) and rhinosinusitis.
A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
A61B 17/24 - Surgical instruments, devices or methods for use in the oral cavity, larynx, bronchial passages or noseTongue scrapers
Described here are devices, methods, and kits for treating sinusitis and related respiratory conditions by locally delivering active agents to the osteomeatal complex over a sustained period of time. The devices may be passively fixed within the osteomeatal complex and/or include one or more features that actively fix it within the osteomeatal complex. The devices may optionally include a portion that extends into a sinus ostium, sinus cavity, and/or the nasal passage to deliver an active agent.
A01N 25/00 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests
A61K 47/00 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient
70.
Device and methods for treating paranasal sinus conditions
Described here are paranasal sinus devices for treating paranasal sinus conditions. The devices include a cavity member, ostial member, and nasal portion. One or more of the cavity member, ostial member, and nasal portion may deliver an active agent for sustained release to treat the paranasal sinus condition. Exemplary paranasal sinus conditions are sinus inflammation due to functional endoscopic sinus surgery (FESS) and rhinosinusitis.
The invention provides biodegradable implants for treating sinusitis. The biodegradable implants have a size, shape, density, viscosity, and/or mucoadhesiveness that prevents them from being substantially cleared by the mucociliary lining of the sinuses during the intended treatment period. The biodegradable implants include a sustained release therapeutic, e.g., an antibiotic, a steroidal anti-inflammatory agent, or both. The biodegradable implants may take various forms, such as rods, pellets, beads, strips, or microparticles, and may be delivered into a sinus in various pharmaceutically acceptable carriers.
