The present disclosure relates to administration of carotenoids to provide a prebiotic effect for modification of gut microbiome, thereby increasing counts of Bifidobacterium adolescentis and/or decreasing counts of pathology-associated bacteria from phylum Bacteroidetes, and its particular genus Prevotella, and also genera from other phyla such as Desulfovibrio and Dialister, and resulting in improved systemic effects.
The present disclosure relates generally to lipid oxygen, and blood lipoprotein oxygen in particular, as a new treatment target and as screen for developing new therapeutic treatments, which in turn can support and improve lipid oxygen level. The present disclosure further generally relates to dry chemistry -based assays for catalymetric measurement of oxygen in biological samples, in particular to point-of- care tests for catalymetric measurement of oxygen in biological samples.
G01N 33/49 - Physical analysis of biological material of liquid biological material blood
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
G01N 33/92 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving lipids, e.g. cholesterol
3.
Methods for improving the microbiome and its systemic effect
We describe that carotenoids provide a prebiotic effect and can be used to improve the health of the gut microbiome. Specifically, it is shown that oral administration of lycopene to medium obese subjects resulted in such a modification of gut microbiome that counts of Bifidobacterium adolescentis were increased and counts of Bacteroidetes were decreased.
The invention relates to uses of hydrocarbon / lipid complexes with carotenoids for improvement properties of hydrocarbon-based products as well as related methods and uses.
A23D 9/007 - Other edible oils or fats, e.g. shortenings or cooking oils characterised by ingredients other than fatty acid triglycerides
A23G 1/42 - Cocoa products, e.g. chocolateSubstitutes therefor characterised by the composition containing microorganisms or enzymesCocoa products, e.g. chocolateSubstitutes therefor characterised by the composition containing paramedical or dietetical agents, e.g. vitamins
A23L 5/44 - Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives using carotenoids or xanthophylls
A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives
A23L 33/115 - Fatty acids or derivatives thereofFats or oils
A23D 9/007 - Other edible oils or fats, e.g. shortenings or cooking oils characterised by ingredients other than fatty acid triglycerides
A23L 5/00 - Preparation or treatment of foods or foodstuffs, in generalFood or foodstuffs obtained therebyMaterials therefor
A23L 29/00 - Foods or foodstuffs containing additivesPreparation or treatment thereof
A23L 29/10 - Foods or foodstuffs containing additivesPreparation or treatment thereof containing emulsifiers
A23L 5/43 - Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives
A23L 5/44 - Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives using carotenoids or xanthophylls
The invention relates to uses of hydrocarbon / lipid complexes with carotenoids for improvement properties of hydrocarbon-based products as well as related methods and uses.
A23L 29/00 - Foods or foodstuffs containing additivesPreparation or treatment thereof
A23L 5/44 - Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives using carotenoids or xanthophylls
A23D 9/007 - Other edible oils or fats, e.g. shortenings or cooking oils characterised by ingredients other than fatty acid triglycerides
A23G 1/42 - Cocoa products, e.g. chocolateSubstitutes therefor characterised by the composition containing microorganisms or enzymesCocoa products, e.g. chocolateSubstitutes therefor characterised by the composition containing paramedical or dietetical agents, e.g. vitamins
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
C07J 9/00 - Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Conventional methods for measuring carotenoids are HPLC based approaches which are cumbersome, expensive and not readily accessible. Moreover, these methods cannot be applied when only a small amount of biological sample is available from non-invasive procedures such as the collection of material from the surface of skin or from swabs. The present inventors have overcome a number of technical difficulties to successfully raise for the first time antibodies against carotenoids, particularly against carotenes such as lycopene or xanthophylls such as lutein. Hence, the present invention provides such antibodies against carotenoids, as well as assays for carotenoids employing such antibodies. Given the increasing recognition of the importance of carotenoids, the successful provision of such antibodies and assays allows for quicker, cheaper and more accessible measurement of carotenoids, including in the diagnosis and help of subjects with carotenoid deficiency. Moreover, availability of antibodies against carotenoids, naturally occurring molecules, provides an opportunity to create a range of new therapeutic vehicles not only to boost carotenoid transport to cells and tissues but for targeted delivery of pharmaceutical, nutraceutical and other agents.
This invention relates to the incorporation of bioactive cargo molecules into particles with carotenoids, such as lycopene. The incorporation of a cargo molecule into a carotenoid particle may for example increase the bioavailability of the cargo molecule in the bloodstream compared to other delivery systems. Carotenoid particles as described herein may be useful in the formulation of therapeutic and nutritional compounds for oral administration to individuals.
A61K 31/351 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
A61K 36/00 - Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
29 - Meat, dairy products, prepared or preserved foods
30 - Basic staples, tea, coffee, baked goods and confectionery
31 - Agricultural products; live animals
32 - Beers; non-alcoholic beverages
33 - Alcoholic beverages other than beer
Goods & Services
Soaps; perfumery, essential oils, cosmetics, hair lotions; dentifrices; non-medication toiletries; skincare, skin moisturizing, skin exfoliating and skin treatment creams, lotions, washes and gels; body care products, namely, body care, body moisturising, and body treatment creams, lotions and gels; footcare products, namely, non-medicated foot soaks, pumice stones for personal use, moisturising lotions, creams and gels; sunblock; deodorants for body care, deodorants for human beings, deodorants for personal use; body and shower products, namely, body washes and shower gels; bath salts; medicated toothpaste; toothpaste; mouthwashes Medicated mouthwashes; chewing gum for medical purposes; medicated chewing gum; medicated lotions and creams for the body, skin, face, hands; medicated pre-moistened tissues and wipes; plasters for medical purposes; medical dressings; dietary food supplements for medical use; dietary and nutritional supplements for medical use; chemical products for therapeutic use, namely, statins; pharmaceuticals for the treatment of heart failure, metabolic disorders and diseases, cardiovascular diseases, coronary heart disease, strokes, inflammatory disorders and diseases, viral infections, fungal infections, bacterial infections, cancer, dementia, Alzheimer's disease, diabetes, pre-diabetes, obesity and cellulitis; chemicals for medical use, namely, enzyme inhibiting statins; dietetic and nutritional supplements for medical use; food for babies; baby food; preparations for destroying vermin; fungicides; herbicides; food and dietary supplements, dietary food supplements Preserved, frozen, dried and cooked fruits and vegetables; jellies, jams, fruit preserves; eggs, milk and milk products excluding ice cream, ice milk and frozen yogurt; dairy products excluding ice cream, ice milk and frozen yogurt; yogurt; cheese; butter; hemp milk, soy-based milk and rice milk, all used as milk substitutes; milk based beverages containing milk concentrates, chocolate milk, and milk-based beverages with a chocolate base; chewing gum Processed cereals and preparations made from cereals, namely, oats, oatmeal, whole grains, wheat, bran, rice flakes, barley, rye, buckwheat, quinoa and millet; bread, pastry, confectionery made of sugar; biscuits; cakes; honey; ice cream; desserts, namely, dessert puddings, dessert souffles, ice cream desserts, bakery desserts and dessert mousse; chocolate; cocoa; coffee, tea Live animals; foodstuffs for animals, malt for brewing and distilling Beers; non-alcoholic beverages, namely, carbonated beverages, fruit-based beverages, energy drinks, isotonic drinks, vegetable drinks; mineral and aerated waters; fruit drinks and fruit juices; syrups for making beverages; preparations for making beverages, namely, fruit drinks Alcoholic beverages, except beers
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Dietary food supplements for the treatment of diabetes and metabolic disorders, syndromes and diseases, namely, abdominal obesity, high cholesterol, amyloidosis and high blood pressure; dietary and nutritional supplements for the treatment of diabetes and metabolic disorders, syndromes and diseases, namely, abdominal obesity, high cholesterol, amyloidosis and high blood pressure; pharmaceuticals for the treatment of diabetes and metabolic disorders, syndromes and diseases, namely, abdominal obesity, high cholesterol, amyloidosis and high blood pressure; pharmaceuticals for the treatment of hypertension, chronic inflammation, heart failure, metabolic disorders, syndromes and diseases, namely, abdominal obesity, high cholesterol, amyloidosis and high blood pressure, pre-diabetes, liver staetosis, liver damage, liver cirrhosis, dermatological disorders and diseases, namely, dermatitis, skin pigmentation diseases, sexually transmitted diseases, eczema, psoriasis, acne, burns, sun burns, cellulitis, dry skin, rosacea, scars, skin cancer, wrinkles, photo-aging, UVR damage and age spots, skin and tissue damage, cellulite, reproductive disorders and diabetes; dentifrices; sun block; chewing gum for cosmetic purposes; toothpaste; mouthwashes; body, face, skin and foot lotions and creams; mouthwashes; tissues and wipes impregnated with pharmaceutical lotions and creams; dietary and nutritional supplements for the treatment of hypertension, chronic inflammation, heart failure, metabolic disorders, syndromes and diseases, namely, abdominal obesity, high cholesterol, amyloidosis and high blood pressure, pre-diabetes, liver staetosis, liver damage, liver cirrhosis, dermatological disorders and diseases, namely, dermatitis, skin pigmentation diseases, sexually transmitted diseases, eczema, psoriasis, acne, burns, sun burns, cellulitis, dry skin, rosacea, scars, skin cancer, wrinkles, photo-aging, UVR damage and age spots, skin and tissue damage, cellulite, reproductive disorders and diabetes.
The invention is concerned with food products comprising one or more cocoa bean products and a carotenoid compound, particularly with food products which are, or comprise, chocolate. The products of the invention may be used in reducing elevated total cholesterol, triglycerides and inflammatory damage, as well as improving tissue microcirculation and tissue oxygenation.
A23G 1/42 - Cocoa products, e.g. chocolateSubstitutes therefor characterised by the composition containing microorganisms or enzymesCocoa products, e.g. chocolateSubstitutes therefor characterised by the composition containing paramedical or dietetical agents, e.g. vitamins
A23G 1/32 - Cocoa products, e.g. chocolateSubstitutes therefor characterised by the composition
The invention is in particular concerned with a food product comprising one or more fats or oils and a carotenoid compound. The products of the invention may be used in reducing elevated total cholesterol, triglycerides and inflammatory damage, as well as improving tissue microcirculation and tissue oxygenation.
A23D 7/005 - Edible oil or fat compositions containing an aqueous phase, e.g. margarines characterised by ingredients other than fatty acid triglycerides
A23D 9/007 - Other edible oils or fats, e.g. shortenings or cooking oils characterised by ingredients other than fatty acid triglycerides
The invention is concerned with food products comprising one or more cocoa bean products and a carotenoid compound, particularly with food products which are, or comprise, chocolate. The products of the invention may be used in reducing elevated total cholesterol, triglycerides and inflammatory damage, as well as improving tissue microcirculation and tissue oxygenation.
A23G 1/48 - Cocoa products, e.g. chocolateSubstitutes therefor characterised by the composition containing plants or parts thereof, e.g. fruits, seeds, extracts
A23G 1/42 - Cocoa products, e.g. chocolateSubstitutes therefor characterised by the composition containing microorganisms or enzymesCocoa products, e.g. chocolateSubstitutes therefor characterised by the composition containing paramedical or dietetical agents, e.g. vitamins
The invention is concerned with food products comprising one or more cocoa bean products and a carotenoid compound, particularly with food products which are, or comprise, chocolate. The products of the invention may be used in reducing elevated total cholesterol, triglycerides and inflammatory damage, as well as improving tissue microcirculation and tissue oxygenation.
A23G 1/48 - Cocoa products, e.g. chocolateSubstitutes therefor characterised by the composition containing plants or parts thereof, e.g. fruits, seeds, extracts
A23G 1/32 - Cocoa products, e.g. chocolateSubstitutes therefor characterised by the composition
A23G 1/42 - Cocoa products, e.g. chocolateSubstitutes therefor characterised by the composition containing microorganisms or enzymesCocoa products, e.g. chocolateSubstitutes therefor characterised by the composition containing paramedical or dietetical agents, e.g. vitamins
19.
ANTIBODY SPECIFIC FOR TRANS - RESVERATROL AND USE THEREOF
The present invention provides a method of detecting or measuring trans-Resveratrol (tRV) in a sample, comprising: contacting a sample to be tested with an antibody against tRV, or an antigen binding fragment of such an antibody; and detecting or measuring any tRV bound by the antibody or antibody fragment. The invention also provides an antibody against trans-Resveratrol.
The invention relates to fungal cells and spores, as well as extracts of either, for use,in particular, in prevention or treatment of Chlamydia, or Helicobacter pylori or other infections, inflammation, inflammatory, lysosomal, acidic, SOD- or IgG or other immunoglobulin - peroxidases or hydrogen peroxide induced or other forms of oxidative damage, atherosclerosis, heart disease, stomach, intestinal and liver inflammatory conditions and their complications, promoting or stimulating regeneration or healing of wounds, burns, ulcers, or other forms of damaged or aged tissues, or in reducing elevated cholesterol and/or triglycerides levels In a preferred instance, the fungal cells or spores are those used in the manufacture of fungal fermented cheeses or other food stuff or beverages, particular fungal blue or white cheeses.
A61K 8/99 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
G01N 33/564 - ImmunoassayBiospecific binding assayMaterials therefor for pre-existing immune complex or autoimmune disease
This invention relates to the incorporation of bioactive cargo molecules into particles with carotenoids, such as lycopene. The incorporation of a cargo molecule into a carotenoid particle may for example increase the bioavailability of the cargo molecule in the bloodstream compared to other delivery systems. Carotenoid particles as described herein may be useful in the formulation of therapeutic and nutritional compounds for oral administration to individuals.
03 - Cosmetics and toiletries; cleaning, bleaching, polishing and abrasive preparations
05 - Pharmaceutical, veterinary and sanitary products
29 - Meat, dairy products, prepared or preserved foods
30 - Basic staples, tea, coffee, baked goods and confectionery
31 - Agricultural products; live animals
32 - Beers; non-alcoholic beverages
33 - Alcoholic beverages other than beer
Goods & Services
Soaps; perfumery, essential oils, cosmetics, hair lotions;
dentifrices; toiletries; skincare products; body and foot
care products; sunblock; deodorants; body and shower
products; chewing gum for cosmetic purposes; bath salts;
medical toothpaste; toothpaste; mouthwashes; body, face,
skin and foot lotions and creams. Mouthwashes; chewing gum for medical purposes; medicated
chewing gum; medicated lotions and creams for the body,
skin, face, hands; tissues and wipes impregnated with
pharmaceutical lotions and creams; plasters; materials for
dressing; dietary food supplements and substances for
medical use; dietary and nutritional supplements for medical
use; chemical products for therapeutic use; therapeutic
drugs and agents; pharmaceuticals; chemicals for medical
use; dietetic substances for medical use; food for babies;
infants' food; preparations for destroying vermin;
fungicides; herbicides. Preserved, frozen, dried and cooked fruits and vegetables;
jellies, jams, preserves; eggs, milk and milk products;
dairy products; yoghurt; cheese; butter; milk substitutes;
milk based beverages; milk, cream and milk substitute based
desserts; food and dietary supplements, not for medical
purposes, not included in other classes. Cereals and preparations made from cereals; bread, pastry,
confectionery; biscuits; cakes; honey; ice cream; desserts;
chocolate; cocoa; coffee, tea; food and dietary supplements,
not for medical purposes, not included in other classes. Agricultural, horticultural and forestry products and grains
not included in other classes; live animals; foodstuffs for
animals, malt. Beers; non-alcoholic beverages; mineral and aerated waters
and other non-alcoholic drinks; fruit drinks and fruit
juices; syrups and other preparations for making beverages. Alcoholic beverages (except beers).
