Abstract

It is provided a positioning device (1) for ultrasound probe (10) comprising a membrane (2) configured to adhere to a knee (100) of a user, defining one or more at a choice of a reference point (2a) configured to be positioned at the centre of the patella of the knee (100) and a reference line (2b) configured to be positioned at the rear bend line of the knee (100), and including a plurality of openings (3, 3', 3", 3"') each defining an amplitude configured to allow the probe (10) to be brought into contact with the knee (100) exclusively through the opening (3, 3', 3", 3") and a centre (3a, 3a', 3a") positioned at a predetermined point relative to the reference point (2a) or reference line (2b) to allow the probe (10) to investigate specific points of the knee (10) in a controlled manner.

IPC Classes  ?

• A61B 8/08 - Clinical applications
• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves

Abstract

Described herein is a device for an intervention of reconstruction of a cruciate ligament that includes a penetrator defining a first passage lumen, and sleeve member coupled to the penetrator and defining a second passage lumen that is in communication with the first passage lumen. The penetrator is configured for being introduced into a tibial plate and for receiving a replacement cruciate ligament through the first passage lumen. The sleeve member is configured for receiving the replacement cruciate ligament through the second passage lumen.

IPC Classes  ?

• A61F 2/08 - MusclesTendonsLigaments

Abstract

A system for the therapeutic treatment of joints comprising a composite material comprising a biodegradable polymer matrix and a plurality of piezoelectric particles adapted to generate local electric charges in response to an external stimulation made by means of ultrasound, said plurality of piezoelectric particles being dispersed in the matrix. The composite material also comprises a plurality of stamina cells dispersed in the biodegradable polymer matrix and a plurality of carbon-based particles. The system also comprises a releasing device, arranged to deposit the composite material in a joint cavity at predetermined areas of the cartilage, and a stimulator device arranged to emit ultrasound at a predetermined frequency, a predetermined intensity and for a predetermined time of application, in such a way that, when the device is located near a joint wherein the composite material has been deposited, said ultrasound stimulate the plurality of piezoelectric particles.

IPC Classes  ?

• A61L 27/38 - Animal cells
• A61L 27/44 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
• A61L 27/52 - Hydrogels or hydrocolloids
• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin
• A61N 1/20 - Applying electric currents by contact electrodes continuous direct currents
• A61N 1/32 - Applying electric currents by contact electrodes alternating or intermittent currents
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Abstract

Described herein is a device (1) for surgical reconstruction of a cruciate ligament (LC), comprising: • - a penetrator (2) defining a first passage lumen (6), and • - a sleeve member (4) coupled to the penetrator (2) and defining a second passage lumen (8), the second passage lumen (8) being in communication with the first passage lumen (6), wherein: • the penetrator (2) is configured for being introduced into a tibial plate (TP) and for receiving a replacement cruciate ligament (LC) through said first passage lumen (6), and • the sleeve member (4) is configured for receiving the replacement cruciate ligament (LC) through said second passage lumen (8).

IPC Classes  ?

• A61F 2/08 - MusclesTendonsLigaments
• A61L 27/38 - Animal cells

Abstract

A surgical instrument (1) to measure the tension between two soft tissues to be sutured. The surgical instrument (1) has two arms (2), which are hinged to one another so as to rotate relative to one another around a rotation axis (3). Each arm (2) has a holding end (4), which is provided with a holding member (5) designed to grip a corresponding soft tissue, and an operating end (6), which is opposite the holding end (4) and is designed to be pressed by a surgeon's fingers. The surgical instrument (1) has a measuring device (10), which is interposed between the two arms (2) and is designed to measure a return force with which the two holding ends (4) tend to be moved away from one another.

IPC Classes  ?

• A61B 17/28 - Surgical forceps

Abstract

A system for the therapeutic treatment of joints comprising a composite material (10) arranged to the therapeutic treatment of joints, said composite material (10) comprising a biodegradable polymer matrix (11) and a plurality of piezoelectric particles (12) adapted to generate local electric charges in response to an external stimulation made by means of ultrasound, said plurality of piezoelectric particles (12) being dispersed in the matrix. The composite material (10) also comprises a plurality of stamina cells (13) dispersed in the biodegradable polymer matrix (11) and a plurality of carbon-based particles. The system also comprises a releasing device (20), arranged to deposit the composite material (10) in a joint cavity at predetermined areas of the cartilage, and a stimulator device (30) arranged to emit ultrasound at a predetermined frequency, a predetermined intensity and for a predetermined time of application, in such a way that, when the device is located near a joint wherein the composite material (10) has been deposited, said ultrasound stimulate the plurality of piezoelectric particles (12).

IPC Classes  ?

• A61L 27/38 - Animal cells
• A61L 27/44 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
• A61L 27/52 - Hydrogels or hydrocolloids
• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin
• A61N 1/20 - Applying electric currents by contact electrodes continuous direct currents
• A61N 1/32 - Applying electric currents by contact electrodes alternating or intermittent currents
• B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Goods & Services

Acaricides; Acids for pharmaceutical purposes; Mineral waters for medical purposes; Thermal water; Nutritional supplements; Alcohol for pharmaceutical purposes; Dietetic foods adapted for medical purposes; Infant formula; Analgesics; Anaesthetics; Antibiotics; Anticoagulants; Antiseptics; Antihistamines; Anti-viral agents; Sanitary towels; Styptic preparations; Balms for medical purposes; Cotton swabs for medical purposes; Bactericides; Bandages for dressings; Surgical bandages; Adhesive bandages; Beta blockers; Medicinal drinks; Dietetic beverages adapted for medical purposes; Biocides; Sedatives; Candy, medicated; Caustics for pharmaceutical purposes; Stem cells for medical purposes; Plasters, materials for dressings; Chloroform; Adjuvants for medical purposes; Collagen for medical purposes; Collyrium; Medicated mouthwash; Cultures of microorganisms for medical or veterinary use; Biological tissue cultures for medical purposes; Cachets for medicinal purposes; Cotton for medical purposes; Antibiotic creams; Therapeutic creams [medical]; Decongestants; Decoctions for pharmaceutical purposes; Depuratives; Deodorants, other than for human beings or for animals; Air deodorizing preparations; Slimming pills; Disinfectants; Disinfectants for hygiene purposes; Haemoglobin; Enzymes for medical purposes; Medicinal herbs; Balsamic preparations for medical purposes; Herbal extracts for medical purposes; Plant extracts for pharmaceutical purposes; Medicinal mud; Febrifuges; Ferments for pharmaceutical purposes; Phosphates for pharmaceutical purposes; Gauze for dressings; Gases for medical purposes; Gelatine for medical purposes; Germicides; Glycerine for medical purposes; Glycerophosphates; Glucose for medical purposes; Immunostimulants; Medicinal infusions; Transplants [living tissues]; Insulin; Dietary and nutritional supplements; Food supplements; Vitamin supplements; Iodine for pharmaceutical purposes; Isotopes for medical purposes; First-aid boxes, filled; Lecithin for medical purposes; Lotions for pharmaceutical purposes; Dental impression materials; Material for dental prostheses; Medicines for dental purposes; Narcotics; Medicinal oils; Oxygen for medical purposes; Nappies for babies and incontinents; Pastilles for pharmaceutical purposes; Blood plasma; Pomades for medical purposes; Multi-vitamin preparations; Bronchodilating preparations; Bacterial preparations for medical purposes; Pharmaceutical preparations; Medical preparations; Antiparasitic preparations; Sunburn ointments; Preparations for the treatment of burns; Pharmaceuticals; Sanitary preparations for medical purposes; Sterilizing preparations; Chemical reagents for medical use; Diagnostic reagents for medical use; Salts for medical purposes; Blood for medical purposes; Medicated and sanitising soaps and detergents; Serums; Soporifics; Dietetic substances adapted for medical use; Medicinal sprays; Vulnerary sponges; Steroids; Medicinal ointments; Vaccines. Clothing for protection against radiation; Laboratory apparatus and instruments; Precision measuring apparatus; Regulating apparatus, electric; Measuring devices, electric; Chemistry apparatus and instruments; Weighing apparatus and instruments; Photographic apparatus and instruments; Optical apparatus and instruments; Computer software applications, downloadable; Mobile apps; Talking books; Scales; Decompression chambers; Clothing especially made for laboratories; Optical lenses; Spectacle lenses; Magnets; Instruction manuals in electronic format; Microscopes; Measuring apparatus; Spectacles; Laboratory pipettes; Test tubes; Electronic publications, downloadable; Laboratory robots; Image scanners; Software; Mirrors [optics]; Measuring instruments; Instruments for diagnosis [for scientific use]; Temperature measuring instruments; Thermometers. Sterile clothing for surgical use; Protective clothing for medical purposes; Corsets for curative purposes; Needles for medical purposes; Infrared apparatus for surgical purposes; Medical and veterinary apparatus and instruments; Massage apparatus; Physical exercise apparatus for medical purposes; Physiotherapy and rehabilitation equipment; Exercising apparatus for medical rehabilitative purposes; Computer controlled exercise apparatus for therapeutic use; Electro-stimulation apparatus for use in therapeutic treatment; Heat treatment apparatus; Apparatus for electrical muscle stimulation; Heat therapy instruments; Heating cushions, electric, for medical purposes; Therapeutic devices adapted for the disabled; Transcutaneous electrical muscle stimulators; Medical apparatus and instruments; Apparatus for tumour diagnosis; Radiotherapy apparatus; Apparatus for the regeneration of stem cells for medical purposes; Resuscitation apparatus; Bandages for orthopaedic purposes; Instrument cases for use by doctors; Elastic stockings for surgical purposes; Cooling patches for medical purposes; Cervical collars; Defibrillators; Bandages, elastic; Plaster for medical or surgical purposes; Ultraviolet ray lamps for medical purposes; Lasers for medical purposes; Therapeutic facial masks; Magnets for therapeutic use; Armchairs for medical or dental purposes; Medical infusion pumps; Containers especially made for medical waste; Syringes for injections; Splinting materials for medical use; Medical instruments; Acupuncture instruments; Cases fitted for medical instruments; Diagnostic imaging apparatus for medical use; Diagnostic apparatus for medical purposes; Endoscopic apparatus; Medical imaging apparatus; Medical apparatus for use in laparoscopy; Testing apparatus for medical purposes; Sphygmotensiometers; Electrocardiographs; Endoscopes; Probes for medical purposes; Stethoscopes; Fibre optic instruments for medical purposes; Thermometers for medical purposes; Surgical amputaters; Surgical apparatus and instruments; Anaesthetic apparatus; Apparatus for orthopaedic purposes; Catheters for medical use; Knives for surgical purposes; Compressors [surgical]; Bone retractors; Surgical retractors; Scissors for surgery; Forceps; Suture and wound closing materials and products; Surgical forceps; Surgical robots; Scalpels; Saws for surgical purposes; Splints, surgical; Surgical instruments; Orthodontic appliances; Dental drills; Orthodontic instruments; Ambulance stretchers; Pads for preventing pressure sores on patient bodies; Air cushions for medical purposes; Cushions for medical purposes; Invalids' hoists; Surgical drapes; Waterbeds for medical purposes; Beds specially made for medical purposes; Air beds for medical purposes; Furniture especially made for medical purposes; Operating tables; Tables for use in the treatment of patients; Compression panty hose; Surgical scrub suits; Medical gowns; Abdominal belts; Belts for medical purposes; Abdominal corsets; Surgical gloves; Compression garments; Masks for use by medical personnel; Artificial limbs; Orthopaedic implants; Artificial organs and implants; Orthopaedic hip prostheses; Artificial cartilage; Artificial implants; Medical devices, namely, intravascular implants comprised of artificial material; Medical devices for spinal disc repair in the nature of spinal disc implants made from artificial substances; Spinal implants composed of artificial material; Transplant protheses for use in surgery; Orthopedic joint implant prostheses; Prostheses for surgical treatment; Prostheses for medical treatment; Biodegradable bone fixation implants; Implanted prosthesis; Artificial bones; Bone prostheses; Stents; Dental prostheses; Orthopaedic braces; Vertebral orthopedic apparatus; Orthopedic articles; Walking sticks for medical purposes; Corsets for medical purposes; Orthopaedic footwear; Orthopaedic belts; Wheeled walkers to aid mobility; Bandages for joints, anatomical; Knee bandages, orthopaedic; Arch supports for footwear; Crutches; Orthopaedic soles; Protective screens for protection whilst exposed to x-rays [medical use]; Radiology screens for medical purposes. Aquarelles; Desk top planners; Personal organisers; Pocket diaries; Albums; Stationery; Towels of paper; Writing cases [stationery]; Tickets; Note pads; Pads [stationery]; Paper bags for household use; Envelopes [stationery]; Calendars; Printing fonts; Paper; Writing paper; Paperweights; Desk mats; Folders for papers; Paper folders; Picture postcards; Catalogues; Printed certificates; Cardboard containers; Paper boxes; Photograph mounts; Covers for postage stamps; Date stamps; Transfers [decalcomanias]; Paintings; Graphic prints; Handkerchiefs of paper; Clips for offices; Photographs [printed]; Postage stamps; Newspapers; Rubber erasers; Pictures; Printed invitations; Blackboards; Small blackboards; Books; Lithographs; Manuals [handbooks]; Terrestrial globes; Pencils; Monographs; Adhesive tapes for stationery or household purposes; Paper ribbons, other than haberdashery or hair decorations; Pamphlets; Pastels [crayons]; Brush pens; Pens [office requisites]; Periodicals; Pencil holders; Penholders; Document holders [stationery]; Pen cases; Posters made of paper; Printed publications; Writing or drawing books; Art pictures; Daily newspaper; Loose-leaf binders; Portraits; Medical journals; Magazines [periodicals]; Index books; Conical paper bags; Paper sacks; Garbage bags of paper or of plastics; Face towels of paper; Cellulose wipes; Boxes of paper or cardboard; Bookmarkers; Place cards; Coasters of cardboard; Printed matter; Art prints; Fountain pens; Paper washcloths; Note books; Paper knives [letter openers]; Pencil sharpeners; Tablecloths of paper; Tablemats of paper; Table napkins of paper; Flyers. Clothing for pets; Travelling sets [leatherware]; Tie cases for travel; Key cases made of leather; Key cases; Luggage; Walking staffs; Trunks [luggage]; Bags; Travel baggage; Bags for sports; Wheeled shopping bags; Garment carriers; Book bags; Small bags for men; Purses; Handbags; Briefcases; School bags; Carrying cases for documents; Labels of leather; Leather leashes; Rucksacks; Daypacks; Suitcases; Attaché cases; Shoulder belts; Luggage tags; Haversacks; Coin purses, not of precious metal; Wrist mounted purses; Pocket wallets; Card cases [notecases]; Business card cases; Credit card cases [wallets]; Umbrellas and parasols; Bumbags. Indoor aquaria; Cruets; Shoe trees; Napkin rings; Bottle openers, electric and non-electric; Storage tins; Cocktail stirrers; Chopsticks; Drinking glasses; Cups of paper or plastic; Schnapps glasses; Tablecloth holders; Tankards; Kettles, non-electric; Milk pans; Drinking bottles; Isothermic bags; Bottles; Insulating flasks; Refrigerating bottles; Jugs; Busts of porcelain, ceramic, earthenware, terra-cotta or glass; Coffeepots, non-electric; Stemware; Shoe horns; Candelabra [candlesticks]; Pillar candle plates; Decanters; Straws for drinking; Corkscrews, electric and non-electric; Baskets for household purposes; Waste paper baskets; Biodegradable bowls; Droppers for cosmetic purposes; Droppers for household purposes; Glasses [receptacles]; Containers for ice; Containers for pot pourri; Lunch boxes; Heat-insulated containers; Thermal insulated containers for food or beverage; Coupes; Crystal [glassware]; Honey servers; Reusable ice cubes; Mixing spoons [kitchen utensils]; Insulating sleeve holder for beverage cups; Pomanders [containers]; Dental floss dispensers; Hand towel dispensers, other than fixed; Soap dispensers; Water apparatus for cleaning teeth and gums; Hip flasks; Medicated dental floss; Window-boxes; Flasks; Exfoliating mitts; Coffee percolators, non-electric; Spice grinders (Non-electric -); Coffee grinders, hand-operated; Majolica; Rolling pins, domestic; Serving ladles; Nebulizers for household use; Model vehicles [ornaments] made of glass; Model vehicles [ornaments] made of terra-cotta; Model vehicles [ornaments] made of porcelain; Works of art of porcelain, ceramic, earthenware, terra-cotta or glass; Cruet sets for oil and vinegar; China ornaments; Works of art made of glass; Works of art made of earthenware; Shaving brushes; Pestles for kitchen use; Hair combs; Table plates; Paper plates; Disposable table plates; Saucers; Ice tongs; Bread tongs; Sugar tongs; Spoon rests; Trivets [table utensils]; Soap holders; Table napkin holders; Bottle stands; Pill boxes for personal use; Potholders; Containers for household or kitchen use; Thermally insulated containers for food; Portable cool boxes, non-electric; Salt cellars; Coin banks; Cookie jars; Tea caddies; Nutcrackers; Ice buckets; Coffee services [tableware]; Liqueur sets; Tea services [tableware]; Spice sets; Services [dishes]; Vessels of metal for making ices and iced drinks; Brushes; Toothbrushes; Toothbrushes, electric; Sponges; Toothpicks; Knife boards; Glass stoppers; Cups; Teapots; Place mats, not of paper or textile; Kitchen utensils; Toilet utensils; Utensils for household purposes; Perfume vaporizers; Holloware; Pots; Vases; Chamber pots; Trays of paper, for household purposes; Trays for household purposes; Sugar bowls. Dresses; Bath robes; Bandanas [neckerchiefs]; Plastic baby bibs; Bibs, not of paper; Berets; Teddies [underclothing]; Waist cinchers; Leotards; Footwear; Stockings; Socks; Non-slip socks; Sweat-absorbent socks; Breeches for wear; Shirts; Tank tops; Headgear; Hoods [clothing]; Cardigans; Stuff jackets [clothing]; Belts [clothing]; Tights; Shoulder wraps [clothing]; Earbands; Bathing suits; Cravats; Bathing caps; Maternity bands; Headbands [clothing]; Swaddling clothes; Sweat shirts; Kerchiefs [clothing]; Foulards [clothing articles]; Knee-high stockings; Jackets [clothing]; Cagoules; Blousons; Skirts; Overalls; Gloves [clothing]; Clothing containing slimming substances; Paper clothing; Infant wear; Flip-flops; Denim jeans; Leggings [leg warmers]; Lingerie; Jerseys [clothing]; Hosiery; Sweaters; Muffs [clothing]; Sleep masks; Pants; Babies' pants [underwear]; Trousers; Trousers shorts; Slippers; Ear muffs [clothing]; Pyjamas; Polo shirts; Neck scarves [mufflers]; Footmuffs, not electrically heated; Galoshes; Collar protectors; Trouser straps; Tee-shirts; Combinations [clothing]; Uniforms; Dressing gowns; Sun visors; Ladies' clothing; Menswear; Clothing for gymnastics; Clothing; Underwear. Administrative management of hospitals; Hospital management; Organisation of events for commercial and advertising purposes. Maintenance and restoration of works of art; Restoration of architectural works; Restoration of works of art. Organization of sightseeing tours. Organizing cultural and arts events; Organisation of educational events; Rental of artwork; Conducting guided tours; Educational and training services relating to healthcare; Courses (Training -) relating to research and development; Research library services; Lending library services; Training services relating to orthopaedic medicine; Education services relating to medicine; Educational services in the healthcare sector. Consultancy in the field of scientific research; Consultancy in the field of pharmaceutical research; Clinical research; Research and development of vaccines and medicines; Research and development in the pharmaceutical and biotechnology fields; Research and development for the pharmaceutical industry; Research on the subject of pharmaceuticals; Medical research; Medical research laboratory services; Biomedical research services; Technological services and research relating thereto; Medical and pharmacological research services. Providing temporary accommodation; Services for providing food and drink; Preparation of meals; Hotel services; Bar and restaurant services; Food and drink catering. Hospital services; Rest home services; Nursing home services; Medical services; Arranging of accommodation in rest homes; Alternative medicine services; Sports medicine services; Medical examinations; Managed health care services. Psychic consultancy; Provision of expert legal opinions; Providing personal support services for families of patients with life threatening disorders; Mediation; Rental of protective clothing and equipment; Companionship services for the elderly and disabled; Legal services.

Goods & Services

Acaricides; Acids for pharmaceutical purposes; Mineral waters for medical purposes; Thermal water; Nutritional supplements; Alcohol for pharmaceutical purposes; Dietetic foods adapted for medical purposes; Infant formula; Analgesics; Anaesthetics; Antibiotics; Anticoagulants; Antiseptics; Antihistamines; Anti-viral agents; Sanitary towels; Styptic preparations; Balms for medical purposes; Cotton swabs for medical purposes; Bactericides; Bandages for dressings; Surgical bandages; Adhesive bandages; Beta blockers; Medicinal drinks; Dietetic beverages adapted for medical purposes; Biocides; Sedatives; Candy, medicated; Caustics for pharmaceutical purposes; Stem cells for medical purposes; Plasters, materials for dressings; Chloroform; Adjuvants for medical purposes; Collagen for medical purposes; Collyrium; Medicated mouthwash; Cultures of microorganisms for medical or veterinary use; Biological tissue cultures for medical purposes; Cachets for medicinal purposes; Cotton for medical purposes; Antibiotic creams; Therapeutic creams [medical]; Decongestants; Decoctions for pharmaceutical purposes; Depuratives; Deodorants, other than for human beings or for animals; Air deodorizing preparations; Slimming pills; Disinfectants; Disinfectants for hygiene purposes; Haemoglobin; Enzymes for medical purposes; Medicinal herbs; Balsamic preparations for medical purposes; Herbal extracts for medical purposes; Plant extracts for pharmaceutical purposes; Medicinal mud; Febrifuges; Ferments for pharmaceutical purposes; Phosphates for pharmaceutical purposes; Gauze for dressings; Gases for medical purposes; Gelatine for medical purposes; Germicides; Glycerine for medical purposes; Glycerophosphates; Glucose for medical purposes; Immunostimulants; Medicinal infusions; Transplants [living tissues]; Insulin; Dietary and nutritional supplements; Food supplements; Vitamin supplements; Iodine for pharmaceutical purposes; Isotopes for medical purposes; First-aid boxes, filled; Lecithin for medical purposes; Lotions for pharmaceutical purposes; Dental impression materials; Material for dental prostheses; Medicines for dental purposes; Narcotics; Medicinal oils; Oxygen for medical purposes; Nappies for babies and incontinents; Pastilles for pharmaceutical purposes; Blood plasma; Pomades for medical purposes; Multi-vitamin preparations; Bronchodilating preparations; Bacterial preparations for medical purposes; Pharmaceutical preparations; Medical preparations; Antiparasitic preparations; Sunburn ointments; Preparations for the treatment of burns; Pharmaceuticals; Sanitary preparations for medical purposes; Sterilizing preparations; Chemical reagents for medical use; Diagnostic reagents for medical use; Salts for medical purposes; Blood for medical purposes; Medicated and sanitising soaps and detergents; Serums; Soporifics; Dietetic substances adapted for medical use; Medicinal sprays; Vulnerary sponges; Steroids; Medicinal ointments; Vaccines. Clothing for protection against radiation; Laboratory apparatus and instruments; Precision measuring apparatus; Regulating apparatus, electric; Measuring devices, electric; Chemistry apparatus and instruments; Weighing apparatus and instruments; Photographic apparatus and instruments; Optical apparatus and instruments; Computer software applications, downloadable; Mobile apps; Talking books; Scales; Decompression chambers; Clothing especially made for laboratories; Optical lenses; Spectacle lenses; Magnets; Instruction manuals in electronic format; Microscopes; Measuring apparatus; Spectacles; Laboratory pipettes; Test tubes; Electronic publications, downloadable; Laboratory robots; Image scanners; Software; Mirrors [optics]; Measuring instruments; Instruments for diagnosis [for scientific use]; Temperature measuring instruments; Thermometers. Sterile clothing for surgical use; Protective clothing for medical purposes; Corsets for curative purposes; Needles for medical purposes; Infrared apparatus for surgical purposes; Medical and veterinary apparatus and instruments; Massage apparatus; Physical exercise apparatus for medical purposes; Physiotherapy and rehabilitation equipment; Exercising apparatus for medical rehabilitative purposes; Computer controlled exercise apparatus for therapeutic use; Electro-stimulation apparatus for use in therapeutic treatment; Heat treatment apparatus; Apparatus for electrical muscle stimulation; Heat therapy instruments; Heating cushions, electric, for medical purposes; Therapeutic devices adapted for the disabled; Transcutaneous electrical muscle stimulators; Medical apparatus and instruments; Apparatus for tumour diagnosis; Radiotherapy apparatus; Apparatus for the regeneration of stem cells for medical purposes; Resuscitation apparatus; Bandages for orthopaedic purposes; Instrument cases for use by doctors; Elastic stockings for surgical purposes; Cooling patches for medical purposes; Cervical collars; Defibrillators; Bandages, elastic; Plaster for medical or surgical purposes; Ultraviolet ray lamps for medical purposes; Lasers for medical purposes; Therapeutic facial masks; Magnets for therapeutic use; Armchairs for medical or dental purposes; Medical infusion pumps; Containers especially made for medical waste; Syringes for injections; Splinting materials for medical use; Medical instruments; Acupuncture instruments; Cases fitted for medical instruments; Diagnostic imaging apparatus for medical use; Diagnostic apparatus for medical purposes; Endoscopic apparatus; Medical imaging apparatus; Medical apparatus for use in laparoscopy; Testing apparatus for medical purposes; Sphygmotensiometers; Electrocardiographs; Endoscopes; Probes for medical purposes; Stethoscopes; Fibre optic instruments for medical purposes; Thermometers for medical purposes; Surgical amputaters; Surgical apparatus and instruments; Anaesthetic apparatus; Apparatus for orthopaedic purposes; Catheters for medical use; Knives for surgical purposes; Compressors [surgical]; Bone retractors; Surgical retractors; Scissors for surgery; Forceps; Suture and wound closing materials and products; Surgical forceps; Surgical robots; Scalpels; Saws for surgical purposes; Splints, surgical; Surgical instruments; Orthodontic appliances; Dental drills; Orthodontic instruments; Ambulance stretchers; Pads for preventing pressure sores on patient bodies; Air cushions for medical purposes; Cushions for medical purposes; Invalids' hoists; Surgical drapes; Waterbeds for medical purposes; Beds specially made for medical purposes; Air beds for medical purposes; Furniture especially made for medical purposes; Operating tables; Tables for use in the treatment of patients; Compression panty hose; Surgical scrub suits; Medical gowns; Abdominal belts; Belts for medical purposes; Abdominal corsets; Surgical gloves; Compression garments; Masks for use by medical personnel; Artificial limbs; Orthopaedic implants; Artificial organs and implants; Orthopaedic hip prostheses; Artificial cartilage; Artificial implants; Medical devices, namely, intravascular implants comprised of artificial material; Medical devices for spinal disc repair in the nature of spinal disc implants made from artificial substances; Spinal implants composed of artificial material; Transplant protheses for use in surgery; Orthopedic joint implant prostheses; Prostheses for surgical treatment; Prostheses for medical treatment; Biodegradable bone fixation implants; Implanted prosthesis; Artificial bones; Bone prostheses; Stents; Dental prostheses; Orthopaedic braces; Vertebral orthopedic apparatus; Orthopedic articles; Walking sticks for medical purposes; Corsets for medical purposes; Orthopaedic footwear; Orthopaedic belts; Wheeled walkers to aid mobility; Bandages for joints, anatomical; Knee bandages, orthopaedic; Arch supports for footwear; Crutches; Orthopaedic soles; Protective screens for protection whilst exposed to x-rays [medical use]; Radiology screens for medical purposes. Aquarelles; Desk top planners; Personal organisers; Pocket diaries; Albums; Stationery; Towels of paper; Writing cases [stationery]; Tickets; Note pads; Pads [stationery]; Paper bags for household use; Envelopes [stationery]; Calendars; Printing fonts; Paper; Writing paper; Paperweights; Desk mats; Folders for papers; Paper folders; Picture postcards; Catalogues; Printed certificates; Cardboard containers; Paper boxes; Photograph mounts; Covers for postage stamps; Date stamps; Transfers [decalcomanias]; Paintings; Graphic prints; Handkerchiefs of paper; Clips for offices; Photographs [printed]; Postage stamps; Newspapers; Rubber erasers; Pictures; Printed invitations; Blackboards; Small blackboards; Books; Lithographs; Manuals [handbooks]; Terrestrial globes; Pencils; Monographs; Adhesive tapes for stationery or household purposes; Paper ribbons, other than haberdashery or hair decorations; Pamphlets; Pastels [crayons]; Brush pens; Pens [office requisites]; Periodicals; Pencil holders; Penholders; Document holders [stationery]; Pen cases; Posters made of paper; Printed publications; Writing or drawing books; Art pictures; Daily newspaper; Loose-leaf binders; Portraits; Medical journals; Magazines [periodicals]; Index books; Conical paper bags; Paper sacks; Garbage bags of paper or of plastics; Face towels of paper; Cellulose wipes; Boxes of paper or cardboard; Bookmarkers; Place cards; Coasters of cardboard; Printed matter; Art prints; Fountain pens; Paper washcloths; Note books; Paper knives [letter openers]; Pencil sharpeners; Tablecloths of paper; Tablemats of paper; Table napkins of paper; Flyers. Clothing for pets; Travelling sets [leatherware]; Tie cases for travel; Key cases made of leather; Key cases; Luggage; Walking staffs; Trunks [luggage]; Bags; Travel baggage; Bags for sports; Wheeled shopping bags; Garment carriers; Book bags; Small bags for men; Purses; Handbags; Briefcases; School bags; Carrying cases for documents; Labels of leather; Leather leashes; Rucksacks; Daypacks; Suitcases; Attaché cases; Shoulder belts; Luggage tags; Haversacks; Coin purses, not of precious metal; Wrist mounted purses; Pocket wallets; Card cases [notecases]; Business card cases; Credit card cases [wallets]; Umbrellas and parasols; Bumbags. Indoor aquaria; Cruets; Shoe trees; Napkin rings; Bottle openers, electric and non-electric; Storage tins; Cocktail stirrers; Chopsticks; Drinking glasses; Cups of paper or plastic; Schnapps glasses; Tablecloth holders; Tankards; Kettles, non-electric; Milk pans; Drinking bottles; Isothermic bags; Bottles; Insulating flasks; Refrigerating bottles; Jugs; Busts of porcelain, ceramic, earthenware, terra-cotta or glass; Coffeepots, non-electric; Stemware; Shoe horns; Candelabra [candlesticks]; Pillar candle plates; Decanters; Straws for drinking; Corkscrews, electric and non-electric; Baskets for household purposes; Waste paper baskets; Biodegradable bowls; Droppers for cosmetic purposes; Droppers for household purposes; Glasses [receptacles]; Containers for ice; Containers for pot pourri; Lunch boxes; Heat-insulated containers; Thermal insulated containers for food or beverage; Coupes; Crystal [glassware]; Honey servers; Reusable ice cubes; Mixing spoons [kitchen utensils]; Insulating sleeve holder for beverage cups; Pomanders [containers]; Dental floss dispensers; Hand towel dispensers, other than fixed; Soap dispensers; Water apparatus for cleaning teeth and gums; Hip flasks; Medicated dental floss; Window-boxes; Flasks; Exfoliating mitts; Coffee percolators, non-electric; Spice grinders (Non-electric -); Coffee grinders, hand-operated; Majolica; Rolling pins, domestic; Serving ladles; Nebulizers for household use; Model vehicles [ornaments] made of glass; Model vehicles [ornaments] made of terra-cotta; Model vehicles [ornaments] made of porcelain; Works of art of porcelain, ceramic, earthenware, terra-cotta or glass; Cruet sets for oil and vinegar; China ornaments; Works of art made of glass; Works of art made of earthenware; Shaving brushes; Pestles for kitchen use; Hair combs; Table plates; Paper plates; Disposable table plates; Saucers; Ice tongs; Bread tongs; Sugar tongs; Spoon rests; Trivets [table utensils]; Soap holders; Table napkin holders; Bottle stands; Pill boxes for personal use; Potholders; Containers for household or kitchen use; Thermally insulated containers for food; Portable cool boxes, non-electric; Salt cellars; Coin banks; Cookie jars; Tea caddies; Nutcrackers; Ice buckets; Coffee services [tableware]; Liqueur sets; Tea services [tableware]; Spice sets; Services [dishes]; Vessels of metal for making ices and iced drinks; Brushes; Toothbrushes; Toothbrushes, electric; Sponges; Toothpicks; Knife boards; Glass stoppers; Cups; Teapots; Place mats, not of paper or textile; Kitchen utensils; Toilet utensils; Utensils for household purposes; Perfume vaporizers; Holloware; Pots; Vases; Chamber pots; Trays of paper, for household purposes; Trays for household purposes; Sugar bowls. Dresses; Bath robes; Bandanas [neckerchiefs]; Plastic baby bibs; Bibs, not of paper; Berets; Teddies [underclothing]; Waist cinchers; Leotards; Footwear; Stockings; Socks; Non-slip socks; Sweat-absorbent socks; Breeches for wear; Shirts; Tank tops; Headgear; Hoods [clothing]; Cardigans; Stuff jackets [clothing]; Belts [clothing]; Tights; Shoulder wraps [clothing]; Earbands; Bathing suits; Cravats; Bathing caps; Maternity bands; Headbands [clothing]; Swaddling clothes; Sweat shirts; Kerchiefs [clothing]; Foulards [clothing articles]; Knee-high stockings; Jackets [clothing]; Cagoules; Blousons; Skirts; Overalls; Gloves [clothing]; Clothing containing slimming substances; Paper clothing; Infant wear; Flip-flops; Denim jeans; Leggings [leg warmers]; Lingerie; Jerseys [clothing]; Hosiery; Sweaters; Muffs [clothing]; Sleep masks; Pants; Babies' pants [underwear]; Trousers; Trousers shorts; Slippers; Ear muffs [clothing]; Pyjamas; Polo shirts; Neck scarves [mufflers]; Footmuffs, not electrically heated; Galoshes; Collar protectors; Trouser straps; Tee-shirts; Combinations [clothing]; Uniforms; Dressing gowns; Sun visors; Ladies' clothing; Menswear; Clothing for gymnastics; Clothing; Underwear. Administrative management of hospitals; Hospital management; Organisation of events for commercial and advertising purposes. Maintenance and restoration of works of art; Restoration of architectural works; Restoration of works of art. Organization of sightseeing tours. Organizing cultural and arts events; Organisation of educational events; Rental of artwork; Conducting guided tours; Educational and training services relating to healthcare; Courses (Training -) relating to research and development; Research library services; Lending library services; Training services relating to orthopaedic medicine; Education services relating to medicine; Educational services in the healthcare sector. Consultancy in the field of scientific research; Consultancy in the field of pharmaceutical research; Clinical research; Research and development of vaccines and medicines; Research and development in the pharmaceutical and biotechnology fields; Research and development for the pharmaceutical industry; Research on the subject of pharmaceuticals; Medical research; Medical research laboratory services; Biomedical research services; Technological services and research relating thereto; Medical and pharmacological research services. Providing temporary accommodation; Services for providing food and drink; Preparation of meals; Hotel services; Bar and restaurant services; Food and drink catering. Hospital services; Rest home services; Nursing home services; Medical services; Arranging of accommodation in rest homes; Alternative medicine services; Sports medicine services; Medical examinations; Managed health care services. Psychic consultancy; Provision of expert legal opinions; Providing personal support services for families of patients with life threatening disorders; Mediation; Rental of protective clothing and equipment; Companionship services for the elderly and disabled; Legal services.

Abstract

The present invention relates to exosomes negative for the expression of CD99, that is, CD99- exosomes, characterized by specific molecular markers. Moreover, the present invention relates to a pharmaceutical composition which comprises said exosomes and the derived medical uses of said exosomes and/or of the composition.

IPC Classes  ?

• C12N 15/11 - DNA or RNA fragmentsModified forms thereof

Abstract

The invention relates to an articulated orthosis (1,1') comprising a first shell (2,2') to be associated to a foot (20,20'), a second shell (3,3') to be associated to a leg (30,30'), and a pair of joints (10,10',10",10"'); each joint (10,10',10",10"') in turn comprises a first inner plate (4,4',4",4"') integral with the first shell (2,2') on the opposite side to the foot (20,20'), a second outer plate (5,5',5",5"') integral with the second shell (3,3') on the opposite side to the leg (30,30') and provided with a hole (50,50',50",50"'), a spacer (6,6',6",6"'), a threaded counter-plate (7,7',7",7'"), and a connecting pin (8,8',8",8"') integral with the first inner plate (4,4',4",4"') and whose head is in abutment on the first shell (2,2') on the side opposite to the first inner plate (4,4',4",4"'), wherein the hole (50,50',50",50"') of the second outer plate (5,5',5",5"') has a diameter greater than the diameter of the spacer (6,6',6",6"') to obtain a mutual radial clearance, and wherein the spacer (6,6',6",6"') passes through the hole (50,50',50",50"') of the second outer plate (5,5',5",5"') and is arranged in contact with the first inner plate (4,4',4",4"') and with the threaded counter-plate (7,7' ',7" ',7'"), and wherein the distance between the outer surface (40) of the first plate (4,4',4",4"') and the inner surface (70) of the threaded counter-plate (7,7', 7", 7"') is determined by the length of the spacer (6,6',6",6"') and is greater than the thickness of the second outer plate (5,5',5",5"') to obtain a mutual axial clearance, so that the pair of said joints (10,10',10",10"') has the axes of the connecting pins (8,8',8",8"') aligned with each other and allows the first shell (2,2') and the second shell (3,3') to perform a relative movement with six degrees of freedom consisting in two independent translations in the sagittal plane, a translation in the mediolateral direction, a rotation in the sagittal plane with respect to a mediolateral axis, a rotation in the frontal plane with respect to an anterior-posterior axis and a rotation in the transverse plane with respect to a longitudinal axis, so that the axis of rotation of the pair of joints (10,10',10",10"') is floating around the anatomical center of a user's anatomical joint and the articulated orthosis (1,1') follows the natural kinematics of the user's anatomical joint.

IPC Classes  ?

• A61F 5/01 - Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces

Abstract

The invention relates to compounds of general formula (I) and pharmaceutically acceptable salts thereof: (I) wherein Ri is selected from an SCN— group or is an RCONH— group; in particular, where Ri=RCONH, R is selected from an aromatic benzene ring substituted with an SCN— group in the ortho, meta or para position, according to the following formula: SCN— or R is a C1-C4 alkyl chain, substituted with an SCN— group; n can be equal to 0 or else 1. The invention also relates to the use of such compounds for the treatment of osteoporosis and in general of bone pathologies characterized by a progressive loss of bone mass, for example rheumatoid arthritis, hyperparathyroidism or bone tumor metastases.

IPC Classes  ?

• C07C 331/28 - Isothiocyanates having isothiocyanate groups bound to carbon atoms of six-membered aromatic rings
• A61K 31/663 - Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
• C07C 331/24 - Isothiocyanates having isothiocyanate groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings
• C07F 9/38 - Phosphonic acids [R—P(:O)(OH)2]Thiophosphonic acids

Abstract

The invention relates to compounds of general formula (I) and pharmaceutically acceptable salts thereof: (I) wherein Ri is selected from an SCN- group or is an RCONH- group; in particular, where Ri = RCONH, R is selected from an aromatic benzene ring substituted with an SCN- group in the ortho, meta or para position, according to the following formula: SCN- or R is a C1 -C4 alkyl chain, substituted with an SCN- group; n can be equal to 0 or else 1. The invention also relates to the use of such compounds for the treatment of osteoporosis and in general of bone pathologies characterised by a progressive loss of bone mass, for example rheumatoid arthritis, hyperparathyroidism or bone tumour metastases

IPC Classes  ?

• C07C 331/24 - Isothiocyanates having isothiocyanate groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings
• A61K 31/663 - Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
• C07F 9/38 - Phosphonic acids [R—P(:O)(OH)2]Thiophosphonic acids

Abstract

Device for external orthopedic fixations, which comprises one or more frames (1; 61; 71) which have a substantially and/or partially annular shape and are suitable for being arranged around a limb to surround it at least partially, wherein one or more rods (2, 36; 46; 96; 106; 110) are fixed to at least one frame (1; 61; 71) by means of at least one locking mechanism (3, 6; 23; 56; 86) provided with at least two jaws (10, 11, 30, 31; 26, 27; 57, 58; 87, 88) which, when they are closed, tighten the locking mechanism (3, 6; 23; 56; 86) to a portion of the frame (1; 61;71) by exerting a prevalently axial force, wherein said jaws (10, 11, 30, 31; 26, 27; 57, 58; 87, 88) are closed by means of a cam mechanism (13, 33) suitable for being actuated by rotating at least one lever (12, 32; 90) pivoted to a first jaw (10, 30) and provided with one or more cam surfaces (13, 33) cooperating with at least one surface of the second jaw (11, 31).

IPC Classes  ?

• A61B 17/62 - Ring frames, i.e. devices extending around the bones to be positioned
• A61B 17/64 - Devices extending alongside the bones to be positioned

Abstract

The present invention relates to an in vitro method for determining a pathology associated with a local and/or systemic increase in bone resorption, said pathology preferably being selected from the group consisting in: osteoporosis, osteopenia and osteolysis. Moreover, the method of the present invention makes it possible to prevent and/or limit the complications associated with said pathological conditions, in particular pathological fractures.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The present invention relates to a single-chain variable fragment (scFv) able to recognize an epitope of the extracellular domain of CD99 human protein. The single-chain variable fragment is able to recognize and specifically and selectively bind the epitope of the extracellular domain of CD99 human protein expressed on Ewing sarcoma cells. The fragment can thus be used for the diagnosis and 10 treatment of Ewing sarcoma.

IPC Classes  ?

• C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum

Abstract

The present invention relates to a magnetic hybrid hydrogel comprising a biocompatible, bioreabsorbable polymer crosslinked with magnetic particles which act as crosslinking agents. The polymer can be a polysaccharide chosen from among carboxymethyl cellulose, hyaluronic acid, chitin, alginic acid, alginates, chitosan or combinations thereof; or else a synthetic polymer chosen from among polyacrylic acid, polylactic acid, polyvinylamine or combinations thereof. The magnetic nanoparticles can be nanoparticles of Fe2C>3, Fe304, Fe204 or else mixed nanoparticles of Fe and Co, Mn or Zn, preferably functionalized with -NH2, - COOH,-OH,-SH groups. The hydrogel is used in oncological medicine for the targeted administration and controlled release of a drug, or else in regenerative medicine for applications of cells or other factors for the purpose of regenerating or repairing a tissue or organ.

IPC Classes  ?

• C08J 3/075 - Macromolecular gels
• C08J 3/24 - Crosslinking, e.g. vulcanising, of macromolecules
• C08K 3/00 - Use of inorganic substances as compounding ingredients
• C08B 15/00 - Preparation of other cellulose derivatives or modified cellulose
• A61K 9/06 - OintmentsBases therefor
• A61K 9/00 - Medicinal preparations characterised by special physical form
• C08B 37/00 - Preparation of polysaccharides not provided for in groups Derivatives thereof
• C08F 20/00 - Homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide, or nitrile thereof
• C08F 26/00 - Homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
• C08G 63/00 - Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule

Abstract

The present invention relates to a single-chain variable fragment (scFv) able to recognize an epitope of the extracellular domain of CD99 human protein. The single-chain variable fragment is able to recognize and specifically and selectively bind said epitope expressed on Ewing sarcoma cells. The fragment can thus be used for the diagnosis and treatment of Ewing sarcoma.

IPC Classes  ?

• A61P 35/00 - Antineoplastic agents
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants

Abstract

The present invention relates to a single-chain variable fragment (scFv) able to recognize an epitope of the extracellular domain of CD99 human protein. The single-chain variable fragment is able to recognize and specifically and selectively bind said epitope expressed on Ewing sarcoma cells. The fragment can thus be used for the diagnosis and treatment of Ewing sarcoma.

IPC Classes  ?

• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• A61P 35/00 - Antineoplastic agents

Abstract

An orthopaedic device (1) for the mobile connection of a first bone segment (4) with a second bone segment (5) of an organic system to replace or assist a damaged joint (2) comprises a first component (10) that can be associated with the first bone segment (4) and a second component (11) that can be associated with the second bone segment (5); the first and second components (10, 11) are coupled virtually or physically by a spherical kinematic pair centred at a point (O) that is the centre of a 1-degree-of-freedom spherical motion representing the real relative spatial motion between the first bone segment (4) and the second bone segment (5); the device (1) also comprises connecting elements (20, 21) which guide the relative motion between the first and the second bone segment (4, 5).

IPC Classes  ?

• A61F 2/38 - Joints for elbows or knees

Abstract

The acetabular prosthesis (1) comprises a cup (2) designed to be inserted in a relative acetabulum and a first screw (6) for fixing the cup (2) designed to engage by screwing in a portion of pelvic bone, the cup (2) comprising a wall (3) with a substantially smooth outer face (3a), and a protrusion (4) extending outwards from the wall (3) and connected to the smooth face (3a).

IPC Classes  ?

• A61F 2/34 - Acetabular cups
• A61B 17/80 - Cortical plates

Abstract

The present invention is related to a method for improving human cancer prognostics and diagnostics, to a probe specific for CDKN2A locus at chromosome region 9p 21.3, used in said method and to the use of the method for preparation of a diagnostic tool for analyzing malignancies or aberrations caused by deletions in the specific regions at chromosome 9 and to optimizing clinical trial design for selecting a cancer therapy and to the method for selecting cancer therapy for treatment of cancer.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids

Abstract

A method of treatment of connective tissue includes the steps of providing a biological tissue or organ, coating the tissue or organ with an enzymatic solution capable of phagocytizing at least partly fibroblasts, macrophages, mast cells and other cells responsible for immune and rejection reactions in homologous and heterologous transplantations. The biological tissue or organ, after the treatment with the enzymatic solution is irradiated with ionizing electromagnetic radiations in order to obtain an acellular tissue which maintains its own extracellular matrix unchanged. Preferably, such radiations are gamma radiations having a frequency between 1019 and 1022 Hz, beta radiations or mixtures thereof.

IPC Classes  ?

• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy
• A61F 2/10 - Hair or skin implants
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61F 2/08 - MusclesTendonsLigaments

Abstract

A process for controlling transfusions of blood components, comprising: associating a first transponder (10) with a patient; providing a bag (30) for containing a blood component intended for that patient, said bag (30) comprising a second transponder (40); detecting the UID code of the first transponder (10) and storing it into a predetermined memory area (41a) of the second transponder (40); before giving said patient the transfusion of that blood component, performing the following steps: carrying out a first detection for detecting the UID code of the first transponder (10), carrying out a second detection for detecting the contents of the predetermined memory area (41a) of the second transponder (40), checking whether the results of said first and second comparisons are identical. Also described is a system (1) for putting said method into practice.

IPC Classes  ?

• A61M 1/02 - Blood transfusion apparatus
• G09F 3/00 - Labels, tag tickets, or similar identification or indication meansSealsPostage or like stamps

Abstract

The present invention refers to a porous composite material, wherein at least one interdispersed biopolymer is present, with a calcium-phosphate mineral component comprising from 50 w/% to 95 w/% of α-tricalcium phosphate (α-TCP, α-Ca3 (PO4) 2) and from 5 w/% to 50 w/% of octacalcium phosphate (OCP, Ca8H2(PO4)6-5H2O), to the total weight of the mineral component. Such combination of α-TCP and OCP allows an in vivo faster resorption rate and thereby a faster formation of new bone tissue having a low cristallinity mineral component with nanocrystal structure, features very similar to those of biological apatites. This porous composite material may find application as bone and/or osteal- chart ilagineous substitute (scaffold) and in producing tissue engineering devices.

IPC Classes  ?

• A61L 27/46 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
• A61L 27/42 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having an inorganic matrix
• A61L 27/56 - Porous or cellular materials

Abstract

Composition including autologous mononuclear cells supported on scaffold chosen from the group including lyophilized scaffold or pre-constituted scaffold in the form of membrane or tissue, with possible addition of platelet gel, as well as use of said composition for the preparation of medicaments for surgical treatments.

IPC Classes  ?

• A61K 35/28 - Bone marrowHaematopoietic stem cellsMesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61K 35/32 - BonesOsteocytesOsteoblastsTendonsTenocytesTeethOdontoblastsCartilageChondrocytesSynovial membrane