Provided are a drug and method for treating temporal lobe epilepsy (TLE) in a subject, the method comprising: administering a nucleic acid encoding a NeuroD1 polypeptide to glial cells in hippocampus region of the subject, so that the glial cells express NeuroD1 polypeptides and are transformed into GABAergic neurons. Also provided are a drug and method for forming GABAergic neurons in hippocampus region of a living mammalian brain, the method comprising: administering a nucleic acid encoding NeuroD1 polypeptides to glial cells located in hippocampus region, so that the glial cells express NeuroD1 polypeptides and are transformed into GABAergic neurons.
A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
223222322322233. When the thickness is 1 mm, the glass prepared by either of the two methods has light transmittance of 75-85% for 290-305 nm ultraviolet light that promotes the synthesis of vitamin D in human body, and can efficiently transmit visible light that has a caring effect on human skin and spirit, and mostly block ultraviolet light harmful to human body and infrared light that causes a sensation of heat; thus, the glass can achieve a health care function for human by sunlight that transmits through the glass without the concern of tanning and heat.
In a mass spectrometry method, a deuterium-resolved mass spectrum of a gas sample comprising volatile metabolites that have been excreted from a human or animal subject (50) after ingestion of deuterated water is determined. The deuterium-resolved mass spectrum to determine a presence or amount of at least one deuterated metabolite. Also disclosed is a corresponding mass spectrometry system.
G01N 33/497 - Physical analysis of biological material of gaseous biological material, e.g. breath
H01J 49/04 - Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locksArrangements for external adjustment of electron- or ion-optical components
H01J 49/16 - Ion sourcesIon guns using surface ionisation, e.g. field-, thermionic- or photo-emission
H01J 49/42 - Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
4.
Method for scheduling cars at narrow curve based on parking space for temporary avoidance
Disclosed is a method for scheduling cars at a narrow curve based on a parking space for temporary avoidance. The method includes: fusing car data obtained by laser radar and millimeter wave radar, so as to predict car states and driving trajectories of meeting cars; computing an expected meeting point of the cars through prediction of the driving trajectories of the cars; and executing, on the basis of the expected meeting point, different car avoidance strategies according to road conditions and a number of parking spaces for temporary avoidance, so as to implement car avoidance and scheduling of car meeting at the narrow curve.
G08G 1/00 - Traffic control systems for road vehicles
G08G 1/01 - Detecting movement of traffic to be counted or controlled
G08G 1/048 - Detecting movement of traffic to be counted or controlled with provision for compensation of environmental or other condition, e.g. snow, vehicle stopped at detector
G08G 1/14 - Traffic control systems for road vehicles indicating individual free spaces in parking areas
5.
Camera pose estimation method and system, electronic equipment and readable medium
The present invention relates to the field of artificial intelligence, and in particular, to a camera pose estimation method and system, electronic equipment and a readable medium. The camera pose estimation method includes: acquiring an initial matching set between a first image and a second image, where the first image and the second image are images from different angles for a same scene; performing a mismatch removal operation on the initial matching set based on an optimization network to obtain an optimized matching set, where the optimization network is constructed based on a multi-stage geometric semantic attention network; and acquiring a camera pose result based on the optimized matching set. By removing mismatches, feature matching results between the first image and the second image are more accurate, and thus a more accurate result can be obtained when performing camera pose estimation.
A hollow-core optical fiber with a crescent-shaped fiber core. The optical fiber comprises a crescent-shaped air fiber core (1) and a cladding microstructure region (2), wherein the cladding structure of the optical fiber uses a multi-tubular structure; the crescent-shaped fiber core is located between the outer side of an inner tube and the inner side of an outer tube of the cladding microstructure region (2), thereby forming a crescent-shaped structure; and an inner layer (21) of the cladding microstructure region (2) consists of a plurality of air layers (23) and tubular structures, and an outer layer (22) of the cladding microstructure region (2) also consists of a plurality of air layers (23) and tubular structures. By means of adjusting the size of the air layers and the wall thickness of the tubular structures, anti-resonant light guiding can be realized. The hollow-core optical fiber with a crescent-shaped fiber core has advantages such as an ultra-low transmission loss, a wide light-guide passband, polarization maintenance and an adjustable mode, and is suitable for applications in the fields of optical communications, fiber-optic gyroscopes, etc.
Provided in the present invention are an adjustment system of a water supply thermal storage type thermoelectric generating set, and a design method and operation method therefor. The adjustment system comprises a high-pressure regenerative system, which is provided with a water supply outlet and a water drain outlet, wherein the water supply outlet is connected to a boiler by means of a water supply pipe; and a working medium heat storage system, which is connected to the water supply outlet or the water drain outlet by means of a water intake pipe, and is connected to the water supply pipe by means of a water output pipe. High-temperature supplied water or high-temperature drained water outputted from the high-pressure regenerative system is subjected to heat storage by means of the working medium heat storage system, and the working medium heat storage system can be decoupled or adjustably coupled between the high-pressure regenerative system and the boiler. When a load needs to be rapidly adjusted, the high-pressure regenerative system is decoupled from the boiler, the working medium heat storage system is used to supply water to the boiler so as to increase the feedwater flow and thermal load, and the feedwater flow of the working medium heat storage system is adjusted in combination with the maximum load lifting rate and the maximum load rate adjusting range of the thermoelectric generating set.
Provided are viral vector and recombinant Simian adenovirus. The viral vector carries at least one recombinant genome preparing from the Simian adenovirus genome by replacing E4orf6 gene, knocking out E3 gene, inserting EGFP gene at the loci of E3, or knocking out E1B55K gene. Recombinant Simian adenovirus could be preparing by transfecting the viral vector into host cells for packaging.
Compounds useful for treating or preventing diabetes and related conditions, and for preventing, inhibiting or reversing amylin-amyloid fibril formation, preventing islets of Langerhans (Beta)-cell death, preventing or reversing the transition from soluble human amylin to insoluble human amylin, preventing and inhibiting or reversing cytotoxic amylin fibril formation. The invention relates to compounds of Formula (I): (I)
A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
A61P 5/48 - Drugs for disorders of the endocrine system of the pancreatic hormones
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
C07D 213/64 - One oxygen atom attached in position 2 or 6
10.
Multimodal data heterogeneous transformer-based asset recognition method, system, and device
This invention discloses a multimodal data heterogeneous Transformer-based asset recognition method, system, and device, the method including: collecting various-modal information of an asset, including text information and image information; building an ALBERT model, a ViT model, and a CLIP model; by the ALBERT model, extracting a text information feature; by the ViT model, extracting an image information feature; by the CLIP model, extracting image-text matching information feature; by different channels, applying asset type recognition to information in different modalities; outputting classification information from the different channels; by the CLIP model, generating asset void information; and discriminatively fusing the classification information from the different channels with the matching degree between the image information and the text information obtained by the CLIP model, and outputting final asset class information. This invention realizes comprehensive discrimination by drawing from multiple modalities to improve the accuracy of asset recognition.
A fault-tolerant asset transferring method is provided to prevent financial losses caused by human errors, specifically unintentional mistakes made by the payer. The system introduces a new definition for blockchain transaction parameters, allowing for multi-input transactions. Each payment transaction includes the payee's signature for confirmation and the payer's signature. In addition, a system is designed to handle multi-input asset transfer transactions which incorporate the payer's confirmation. Upon reaching an agreement on the transaction content, each participant generates an independent off-chain signature on the transaction's content. In the event that participants generate a signature on the erroneous content of a transaction, the transaction will be accepted in the blockchain with very low probability due to transaction validation.
G06Q 20/40 - Authorisation, e.g. identification of payer or payee, verification of customer or shop credentialsReview and approval of payers, e.g. check of credit lines or negative lists
12.
METHOD AND SYSTEM FOR ESCROW-FREE ATOMIC CROSS-CHAIN SWAP WITH RECIPIENT'S CONFIRMATION
A system for enabling escrow-free, secure, and convenient atomic asset swaps between blockchains are provided. In detail, when any group of users reach an agreement on the content of cross-chain asset swap transactions, each participant creates an individual signature on the content of each transaction, employs a reversible signature aggregate function to produce an aggregate signature from all his/her individual signatures, and optionally generates a proof to prove the relationship between the aggregated signature and the transaction contents. Sequentially, all the participants exchange these aggregated signatures and optional proofs. Once a participant publishes one of his/her individual signature, the other parties can use both signatures—one from the sender and the other from the recipient—to construct a complete transaction. Once a transaction is broadcast, its corresponding transactions are constructed, and broadcast. Upon all transactions being confirmed by the blockchain nodes or miners, the asset swap between participants is completed.
G06Q 20/36 - Payment architectures, schemes or protocols characterised by the use of specific devices using electronic wallets or electronic money safes
13.
DETECTION METHOD AND DEVICE FOR ENERGY STORAGE DEVICES
A method for detecting a state of an energy storage device (e.g. lithium-ion battery) is provided, which includes acquiring at least one of a change signal of a temperature or a change signal of a pressure inside the energy storage device, and determining the state of the energy storage device based thereon. The method may further include triggering a warning when the state of the energy storage device meets a preset condition, such as when the energy storage device is determined to be in an irreversible state, an internal short circuit state, a safety valve opening state, or a thermal runaway state. A detection device implementing the detection method is also provided, which comprises a sensing module and an analyzing module. The sensing module is arranged at an interior position of the energy storage device, and can include an optical sensor and/or an electrical sensor.
The present invention relates to a pharmaceutical composition for preventing and/or treating neurodegenerative diseases. On the one hand, the active ingredient C21 steroid saponin of the pharmaceutical composition can significantly reduce the generation of an amyloid β-protein in N2a-APP695 cells and increase the clearance of excess A3; and on the other hand, the active ingredient C21 steroid saponin of the pharmaceutical composition can promote the proliferation of neuron cells, and has a protective effect on the neuronal cytotoxicity induced by neurotransmitters such as glutamate caused by the excessive accumulation of A3, thereby comprehensively playing a role in the treatment of neurodegenerative diseases. Therefore, the pharmaceutical composition has good application prospects in the preparation of an A3 formation inhibitor and a neuroprotective agent, and in drugs for preventing or treating neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and Huntington's disease.
A61K 31/573 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
A61K 31/58 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Provided is an optical fiber transmission system, which relates to the field of optical communications and has a better transmission performance. The optical fiber transmission system comprises a first optical fiber, a second optical fiber and a third optical fiber, which are sequentially coupled, wherein the first optical fiber comprises a first port and a second port, and the first port of the first optical fiber is used for coupling a sending device; the second optical fiber comprises a first port and a second port, and the first port of the second optical fiber is coupled to the second port of the first optical fiber; the third optical fiber comprises a first port and a second port, the first port of the third optical fiber is coupled to the second port of the second optical fiber, and the second port of the third optical fiber is used for coupling a receiving device; and the first optical fiber and the third optical fiber are hollow-core optical fibers, and the second optical fiber is a solid-core optical fiber. The embodiments of the present application are applied to optical communications.
Provided in the present application is a hollow-core optical fiber, comprising N first tubular units, N second tubular units and a protective sleeve, wherein the N first tubular units are arranged in a circle, and lean against the protective sleeve; the N second tubular units correspond to the N first tubular units on a one-to-one basis, and each first tubular unit among the N first tubular units is nested inside a corresponding second tubular unit, thus forming, together with the second tubular unit, cladding for confining light beams' propagation within a fiber core; and the cross section of each second tubular unit comprises at least one circular arc structure, the central angle of each circular arc structure being 180-340°. By constructing the cladding from units which comprise one or more circular arc microstructures and confining light beams' propagation within the fiber core, while low loss of the optical fiber is ensured, the size of the optical fiber is also effectively reduced, such that the structure of the hollow-core optical fiber in the present application has good compatibility and is applicable to more extensive application scenarios.
Provided are a self-assembled small molecule peptide and a use thereof in anti-angiogenesis. An amino acid sequence of the self-assembled small molecule peptide is as follows: FFKRPPLKRVRMSADAML. Experiments show that the self-assembled small molecule peptide can inhibit proliferation of vascular endothelial cells, formation of intestinal vessels, and corneal angiogenesis and can achieve an anti-tumor effect by inhibiting angiogenesis, and the self-assembled small molecule peptide has good enzymolysis stability and long half-life, and can be retained in vivo for a long time. Therefore, the self-assembled small molecule peptide can be used for preparing an anti-angiogenesis drug, an anti-tumor drug, or a drug for treating neovascular ocular diseases.
A multi-source image correspondence method and system based on heterogeneous model fitting is provided, the method includes the following steps: constructing a multi-orientation phase consistency model, fusing phase consistency, image amplitude, and orientation detection feature points, constructing logarithmic polar coordinate descriptors with variable-size bins using sub-region grids and orientation histograms, effectively estimating model parameters through heterogeneous model fitting, accumulating matching pairs from different heterogeneous models that meet a preset joint position offset transformation error, outputting a final matching pair, and completing multi-source image correspondence. The present disclosure alleviate the influence of nonlinear radiation distortion by constructing the multi-orientation phase consistency model, constructing logarithmic polar coordinate descriptors with variable-size bins by sub-region grids and orientation histograms, removing an abnormal matching relationship in multi-source images with the heterogeneous model fitting method, thereby improving the accuracy and robustness of feature detection and improving multi-source image correspondence performance.
G06V 10/75 - Organisation of the matching processes, e.g. simultaneous or sequential comparisons of image or video featuresCoarse-fine approaches, e.g. multi-scale approachesImage or video pattern matchingProximity measures in feature spaces using context analysisSelection of dictionaries
G06T 7/73 - Determining position or orientation of objects or cameras using feature-based methods
G06V 10/44 - Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersectionsConnectivity analysis, e.g. of connected components
G06V 10/50 - Extraction of image or video features by performing operations within image blocksExtraction of image or video features by using histograms, e.g. histogram of oriented gradients [HoG]Extraction of image or video features by summing image-intensity valuesProjection analysis
19.
INTRACELLULAR ANTIBODY AND PREPARATION METHOD AND USE THEREOF
Disclosed are an intracellular antibody (intrabody) and a preparation method and a use thereof. The intrabody includes a fragment of the variable region of the heavy chain (VH) of a monoclonal antibody that recognizes mutant huntingtin (mHTT) and a signal sequence of lysosome-associated membrane protein I (LAMP1). The VH fragment includes an amino acid sequence as shown in any one of SEQ. ID NO. 1-3. The intrabody described in this application possesses a bidirectional recognition function, enabling it to bind to and recognize mHTTs as well as specifically recognize lysosomes, thereby realizing the targeted degradation of mutant proteins and improving the degradation efficiency of the mutant proteins.
A pharmaceutical composition for preventing and treating diseases caused by fungi, which pharmaceutical composition comprises a polyene antifungal drug or a pharmaceutically acceptable salt thereof and vitamin D or an analog thereof. The mass ratio of the polyene antifungal drug to vitamin D is from 600:1 to 5:1, preferably from 250:1 to 25:1. The pharmaceutical composition has good antifungal activity, and the active ingredients thereof have a good synergistic effect.
A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
A61K 31/592 - 9,10-Secoergostane derivatives, e.g. ergocalciferol, vitamin D2
A61K 31/593 - 9,10-Secocholestane derivatives, e.g. cholecalciferol, vitamin D3
Disclosed in the present invention is the use of Crassifolin A in promoting mitophagy and treating neurodegenerative diseases. According to the present invention, experiments show that the diterpene compound Crassifolin A can significantly increase mitophagy levels, promote the removal of damaged mitochondria, maintain homeostasis in cells, and has potential effects of treating neurodegenerative diseases and other related diseases; moreover, Crassifolin A is a small-molecule compound that can easily penetrate through the blood-brain barrier to reach the brain so as to play a role, can be extracted from a Thickleaf croton root medicinal material, has the advantages of abundant medicinal sources, easy availability, low drug toxicity and few side effects, and has a good application prospect in the treatment of neurodegenerative diseases.
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
22.
Antioxidant Edible Oil Based on Nano Reverse Micelle System and Preparation Method Thereof
The disclosure belongs to the technical field of edible oil processing, and particularly relates to a preparation method of a novel antioxidant edible oil based on a nano reverse micelle system. The novel antioxidant edible oil includes the following ingredients: 22.5-100 parts by mass of vegetable oil rich in unsaturated fatty acids (>50 wt %); 0.5-6 parts by mass of edible emulsifier; and 3.75-10 parts by mass of dried natural plant. A vegetable oil-edible emulsifier mixture is used as a solvent to extract natural active ingredients in a natural plant (such as rosemary), and a nano reverse micelle system is formed by self-assembly, such that water-soluble and oil-soluble antioxidants coexist in the oil system, thereby jointly improving oxidation stability of oil. The preparation method of the disclosure is simple, efficient, green and safe, has no organic solvent in the whole process, and is easy for scale-up production.
A fiber connecting apparatus and a fiber ferrule preparation method are provided. The connecting apparatus includes a first fiber connector, a second fiber connector, and a pair of adapters. The first fiber connector includes a first fiber ferrule having a central axis through-hole structure, and a first fiber is capable of passing through the first fiber ferrule. The second fiber connector includes a second fiber ferrule having a central axis through-hole structure, and a second fiber is capable of passing through the second fiber ferrule. Two adapters in the pair of adapters are configured to implement docking between the first fiber and the second fiber inside the pair of adapters. Ahead of the first fiber ferrule includes a first fiber limiting structure; and/or a head of the second fiber ferrule includes a second fiber limiting structure.
Method, device and system for building blockchain-based secure aggregation in federated learning with data removal are provided. The method includes: selecting a first quantity of client nodes, to participate in an i-th iteration; sending a list of the selected client nodes to each of the first quantity of client nodes; acquiring model training information transmitted by each of a second quantity of client nodes, the model training information being transmitted in a form of cypher text, where the cypher text is generated by performing homomorphic encryption on the model training information based on pairwise seeds computed for each of the first quantity of client nodes from a symmetric bivariate polynomial and a private seed computed from asymmetric bivariate polynomial; aggregating the cypher text to obtain an aggregate result; and broadcasting a list of the second quantity of client nodes and the aggregate result via a blockchain.
The present invention provides a multi-port converter circuit for integrated grid connection of new energy and energy storage, and a control method. The circuit comprises: at least two alternating-current and direct-current converter units and at least one multi-winding transformer. Two alternating-current and direct-current converter units are in series connection on a direct-current side and then lead out three direct-current terminals. A distributed power generation apparatus and a direct-current load are connected to a direct-current bus. Alternating-current terminals connected to an alternating-current side of the converter units and alternating-current ports connected to an alternating-current power grid are led out from the multi-winding transformer. A three-port converter circuit comprises a "lever" effect of power conversion, device multiplexing of a second converter unit, and direct conversion between alternating-current and direct-current ports. A multi-port converter circuit is further formed by connecting one or more converter units in series or in parallel on the basis of the three-port converter circuit. According to the present invention, optimal design and configuration of key parameters are performed on the basis of the described three-port or multi-port topology, such that the costs of a converter apparatus are significantly reduced and the conversion efficiency is improved.
A method and system for atomic, consistent and accountable cross-chain rewriting are provided. The method is applicable for a blockchain network comprising a set of correlative blockchains. The method includes: in response to a user redaction proposal for any of the correlative blockchains, generating a set of correlative redaction proposals that involve all related transactions depending on a target transaction to be redacted by the user redaction proposal, based on a transaction dependency graph representing a dependency relationship of transactions, wherein at least one of the transactions in the transactions is to be redacted by the user redaction proposal; validating the user redaction proposal and the correlative redaction proposals, according to a predefined cross-chain redaction policy; calling the correlative blockchains for executing the validated redaction proposals; and updating the transaction dependency graph in response to execution of the validated redaction proposals.
An on-chip light splitting mid-infrared detection apparatus and device, and an imaging method. The apparatus comprises a double-color coupling light splitting grating (5), a first spot-size conversion structure (4), a second spot-size conversion structure (6), a first transmission waveguide (2), a second transmission waveguide (7), a first photodetector (1), and a second photodetector (8). Mid-infrared light is incident from the double-color coupling light splitting grating (5) and then undergoes double-color coupling, then passes through the first spot-size conversion structure (4) and the second spot-size conversion structure (6) on two sides of the double-color coupling light splitting grating (5), respectively, and is then transmitted to the first photodetector (1) and the second photodetector (8) via the first transmission waveguide (2) and the second transmission waveguide (7), respectively, and detection for a first wavelength and a second wavelength is output. The first photodetector (1) and the second photodetector (8) are respectively packaged by a first packaging module (3) and a second packaging module (9), and a first refrigeration structure (10) and a second refrigeration structure (11) respectively cover the first packaging module (3) and the second packaging module (9). Interference can be reduced, double-color imaging and high-efficiency, large-bandwidth and multi-wavelength detection are realized, and detector costs are reduced.
G02B 6/42 - Coupling light guides with opto-electronic elements
G02B 6/10 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type
G01J 1/42 - Photometry, e.g. photographic exposure meter using electric radiation detectors
28.
Diversified recommendation method for news based on graph neural network and its device
The embodiment of the invention discloses a diversified recommendation method for news based on graph neural network and its device, which comprises the followings: word segmentation processing is performed on the target news text to obtain a word segmentation set, and vectorization processing is performed on the word segmentation set, so that each word segmentation in the word segmentation set has a word segmentation embedding vector; vectorization processing is performed on a target user group, so that each user in the target user group has a user embedding vector; the word segmentation embedding vector and the user embedding vector are input into the attention mechanism algorithm to obtain the news embedding vector; a graph neural network is constructed according to the user embedding vector and the news embedding vector, and the recommendation model is trained to obtain diversified recommendation results. In the embodiment, firstly, a word segmentation tool is used to segment each news text, and then the embedding vector of news is obtained by using attention mechanism, user interest and word segmentation information, and the corresponding expression is obtained by graph neural network, and the model is optimized, and finally the diversified recommendation results are obtained by calculation.
A battery cell (7), a battery (2), and an electric apparatus. The battery cell (7) comprises a shell (20), an electrode assembly (11) and an optical fiber (8). The electrode assembly (11) is accommodated in the shell (20). The optical fiber (8) comprises a first section (81) and a second section (82), the first section (81) is attached to the electrode assembly (11), the second section (82) is connected to the first section (81) and extends out of the shell (20), the axis of the first section (81) and the axis of the second section (82) are arranged in a staggered manner, and the optical fiber (8) is used for acquiring a state signal of the battery cell (7). By means of the embodiments, a temperature change and a stress of a battery cell can be monitored at the same time, thereby improving the safety and stability of the operation of the battery cell (7).
H01M 10/48 - Accumulators combined with arrangements for measuring, testing or indicating the condition of cells, e.g. the level or density of the electrolyte
G01B 11/16 - Measuring arrangements characterised by the use of optical techniques for measuring the deformation in a solid, e.g. optical strain gauge
G01K 11/32 - Measuring temperature based on physical or chemical changes not covered by group , , , or using changes in transmittance, scattering or luminescence in optical fibres
G01R 31/396 - Acquisition or processing of data for testing or for monitoring individual cells or groups of cells within a battery
30.
THERMAL BARRIER COATING MATERIAL HAVING HIGH FRACTURE TOUGHNESS, CMAS CORROSION RESISTANCE AND ULTRA-HIGH-TEMPERATURE SINTERING RESISTANCE AND PREPARATION AND APPLICATION THEREOF, AND THERMAL BARRIER COATING
EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (China)
JINAN UNIVERSITY (China)
AECC BEIJING INSTITUTE OF AERONAUTICAL MATERIALS (China)
Inventor
Zhang, Xiancheng
Chen, Xiaolong
Tian, Haoliang
Shi, Junmiao
Sun, Binhan
Tu, Shantung
Abstract
22, the crystal defect concentration and the lattice distortion degree are regulated and controlled by means of the doping amount of the rare earth oxides, and a completely stabilized cubic fluorite crystal structure is presented, so that no phase change occurs at room temperature to 1,600°C; and the present invention has the advantages of high toughness, CMAS corrosion resistance, ultra-high-temperature sintering resistance and a long service life.
C04B 35/48 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxides based on zirconium or hafnium oxides or zirconates or hafnates
C04B 35/50 - Shaped ceramic products characterised by their compositionCeramic compositionsProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on rare earth compounds
C04B 35/622 - Forming processesProcessing powders of inorganic compounds preparatory to the manufacturing of ceramic products
C04B 35/626 - Preparing or treating the powders individually or as batches
A specific target-oriented social media tweet sentiment analysis method includes: preprocessing social media tweet data to obtain a target text and a specific target; passing the target text and the specific target through an embedding layer to obtain target text word vectors and obtain a specific target word vector, respectively; passing the target text word vectors through a self-attention structure to obtain a self-attention result; combining the self-attention result with the specific target word vector and passing through a cross-attention structure to obtain cross-attention results; concatenating the cross-attention results to obtain an attention representation matrix; and passing the attention representation matrix through a pooling layer, a fully connected layer and a softmax layer to obtain a sentiment tendency of the specific target. The method, based on an attention mechanism in the transformer structure, fuses a local attention mechanism and an attention mechanism containing position information, the analysis accuracy is improved.
G06Q 50/00 - Information and communication technology [ICT] specially adapted for implementation of business processes of specific business sectors, e.g. utilities or tourism
32.
PYRIDOPYRIMIDINE-BASED COMPOUND AND APPLICATION THEREOF
SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY, CHINESE ACADEMY OF SCIENCES (China)
Inventor
Ding, Ke
Zhang, Xin
Xu, Fang
Ren, Xiaomei
Lu, Xiaoyun
Ma, Dawei
Huang, Weixue
Abstract
The present disclosure provides a class of Pyridopyrimidine compounds having a structure shown in Formula (I) or their pharmaceutically acceptable salts, or stereoisomers or prodrug molecules and applications thereof. The compounds in the present disclosure can efficiently and selectively degrade AKT3 protein in cells without affecting AKT1/2, thereby significantly inhibiting tumor cell proliferation mediated by high expression of AKT3 protein. It can be used to prepare therapeutic drugs for cancer and other diseases related to abnormal expression of AKT3 protein.
The present disclosure provides a class of Pyridopyrimidine compounds having a structure shown in Formula (I) or their pharmaceutically acceptable salts, or stereoisomers or prodrug molecules and applications thereof. The compounds in the present disclosure can efficiently and selectively degrade AKT3 protein in cells without affecting AKT1/2, thereby significantly inhibiting tumor cell proliferation mediated by high expression of AKT3 protein. It can be used to prepare therapeutic drugs for cancer and other diseases related to abnormal expression of AKT3 protein.
C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
33.
Method for Extracting and Separating Various Components from Flaxseed Meal based on Subcritical Composite Solvent
Disclosed in the present disclosure is a method for extracting and separating various components from flaxseed meal based on a subcritical composite solvent, including the following steps: adding an extraction agent to flaxseed meal for subcritical extraction to obtain a crude flax lignan extract and crude flaxseed oil in one step, where the extraction agent includes n-butane and anhydrous ethanol at a volume ratio of 1:1; adding n-hexane to the crude flaxseed oil for fractional extraction, and conducting rotary evaporation to obtain flaxseed oil; and subjecting the flaxseed meal used to hot water extraction to obtain flaxseed gum. In the present disclosure, the subcritical composite solvent used in an extraction process can replace a large number of organic reagents used in a traditional extraction process, and has the characteristics of good solvent effect, environmental friendliness, recyclability, and low burden on the environment.
B01D 3/08 - Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping in rotating vesselsAtomisation on rotating discs
B01D 15/18 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
B01D 15/42 - Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
The present invention belongs to the technical field of homojunction two-dimensional materials, and specifically relates to a preparation method for and use of a two-dimensional double-layer tungsten sulfide homojunction. A chemical vapor deposition method is employed for the two-dimensional tungsten sulfide homojunction, and the growth of nucleation is controlled by adjusting the heating rate and flow rate, thus achieving the formation of a two-dimensional tungsten sulfide homogeneous junction having different twist angles. The Raman peak position of the obtained homogeneous junction experiences an obvious shift. The surface of said junction is clean, undamaged, large in size and high in quality. Moreover, the preparation method of the present invention is simple, features one-step synthesis, and is easy to operate. The present invention provides a material basis for studying fields such as the properties of twisted two-dimensional materials and uses thereof in optoelectronic devices.
Disclosed in the present application are a battery sensor, a battery, and a battery inspection system and method. The battery sensor comprises a transmission optical fiber and a grating assembly consisting of optical fiber gratings with different diameters, wherein the grating assembly is connected to one end of the transmission optical fiber, so as to transmit optical signals by means of the transmission optical fiber. According to the embodiments of the present application, the diameters of the optical fiber gratings are different, so that sensitivities of the optical fiber gratings to temperatures and strains are also different. The grating assembly is disposed inside the battery, and the end of the transmission optical fiber that is not connected to the grating assembly is led out to the outside of the battery, such that in an operating process of the battery, light fields of fiber core modes of the optical fiber gratings in the grating assembly are modulated as the internal temperature and strain of the battery change, such that optical signals output by means of the optical fiber gratings with different diameters present different wavelength changes on a spectrum collection instrument, and change amounts in the internal temperature and strain of the battery can be determined by analyzing wavelength information in a spectrum, thereby realizing in-situ inspection of the battery.
H01M 10/48 - Accumulators combined with arrangements for measuring, testing or indicating the condition of cells, e.g. the level or density of the electrolyte
36.
USE OF SMO INHIBITOR IN PREPARATION OF DRUG FOR PREVENTING, DELAYING OR ALLEVIATING ACCESS STENOSIS OF ARTERIOVENOUS FISTULA
Provided is use of a SMO inhibitor in the preparation of a drug for preventing, delaying or alleviating access stenosis of arteriovenous fistula. It is creatively found herein that a SMO inhibitor can protect endothelial cells under the stimulation of high glucose and alleviate endothelial cell dysfunction, and specifically reduce lactate dehydrogenase (LDH), reduce apoptosis and reduce the production of inflammatory cytokines TNF-α, MCP-1, and IL-6. Furthermore, it is found herein that the SMO inhibitor can improve endothelial cell dysfunction by increasing the blood flow velocity in blood vessels, increasing the inner diameter of the blood vessel, improving the vascular intima thickening and reducing the production of inflammatory cytokines, thereby achieving the purpose of preventing, delaying or alleviating the access stenosis of arteriovenous fistula.
A61K 31/4355 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
A61K 31/4418 - Non-condensed pyridinesHydrogenated derivatives thereof having a carbocyclic ring directly attached to the heterocyclic ring, e.g. cyproheptadine
A61K 31/454 - Non-condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61P 9/14 - VasoprotectivesAntihaemorrhoidalsDrugs for varicose therapyCapillary stabilisers
A broadband anti-resonance hollow-core optical fiber, which inhibits increased losses caused by mode interaction at the long-wavelength side of a light guide passband, thereby effectively widening the low-loss passband of the optical fiber. The broadband anti-resonance hollow-core optical fiber comprises an outer cladding layer and an inner cladding layer; the outer cladding layer is of a hollow tubular structure, and the inner cladding layer is arranged in the outer cladding layer; the inner cladding layer comprises a plurality of rotational symmetry structures, each rotational symmetry structure comprises at least one sheet-shaped structure, and two opposing ends of each sheet-shaped structure are connected to the outer cladding layer.
An in-situ and in-operando internal state detecting system for an energy storage device comprises a first acoustic signal-emitting acoustic signal emission module, an interior-residing optical sensing module, and a first input optical signal-providing signal demodulation module. The optical sensing module receives a second acoustic signal when the first acoustic signal transmits inside the energy storage device, and outputs a first optical signal, which is demodulated and analyzed by the signal demodulation module to obtain acoustic feature information. Optionally, the signal demodulation module also provides a second input optical signal, and the optical sensing module outputs a second optical signal, which is analyzed by the signal demodulation modulation module to obtain optical feature information. Based on the acoustic and optical feature information, one or more internal states of the energy storage device, such as dendrite growth, internal gas generation, electrode expansion, electrolyte aging, or refractive index, etc., can be determined.
H01M 10/48 - Accumulators combined with arrangements for measuring, testing or indicating the condition of cells, e.g. the level or density of the electrolyte
39.
SELENIUM-CONTAINING HETEROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF
The present invention provides a selenium-containing heterocyclic compound with a structure represented by formula (I) or a pharmaceutically acceptable salt thereof or a stereoisomer thereof or a prodrug molecule thereof or a deuterated form thereof. The compound can be used as a KRAS G12D inhibitor for treating highly proliferative diseases, such as cancer.
C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
C07D 421/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having selenium, tellurium, or halogen atoms as ring hetero atoms containing three or more hetero rings
A61K 31/517 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
The present disclosure provides a chitosan-modified opto-hydrodynamic micromotor and a preparation method and use thereof, and belongs to the technical field of micromotors. The chitosan-modified opto-hydrodynamic micromotor provided by the present disclosure is composed of Phaeodactylum tricornutum Bohlin and a chitosan solution. The chitosan-modified opto-hydrodynamic micromotor provided by the present disclosure has high biocompatibility, can non-invasively remove biological threats in a microenvironment containing cells with a sterilization rate reaching about 98%, and can achieve high-efficiency sterilization without affecting cell viability.
Provided in the embodiments of the present application are a battery state detection method and apparatus, and a device and a computer-readable storage medium. The method comprises: collecting an internal spectral curve of a battery; performing envelope analysis on the basis of the spectral curve; and determining change information of an internal state of the battery according to the envelope analysis result. A change in an internal state of a battery usually causes a change in an internal spectral curve of the battery. Envelope analysis is performed on a spectral curve, such that regular envelope change information of an entire spectrum in a plurality of modes can be determined, so as to achieve a continuous response to an internal change of a battery, and state information of the battery can then be accurately analyzed according to the envelope information, which is obtained by means of the analysis, thereby realizing accurate detection of the internal state of the battery.
G01R 31/00 - Arrangements for testing electric propertiesArrangements for locating electric faultsArrangements for electrical testing characterised by what is being tested not provided for elsewhere
42.
APPLICATION OF RILUZOLE IN TREATMENT OF OLIGOSPERMIA
An application of riluzole, a non-hormone compound, in a treatment of oligospermia provides a useful help for solving the problem of male sterility, and has potential application prospects in the field of medicine.
A61K 31/428 - Thiazoles condensed with carbocyclic rings
A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 15/08 - Drugs for genital or sexual disordersContraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
43.
USE OF SESQUITERPENE POLYKETONE COMPOUND AS IMMUNOMODULATOR IN PREVENTING AND TREATING IMMUNE DISEASES
Provided are a sesquiterpene polyketone compound, a pharmaceutical composition, and use thereof as an immunomodulator and in preventing and treating immune diseases. Biological activity assay shows that the sesquiterpene polyketone compound provided herein can be used as an immunomodulator for preventing and/or treating immune-related diseases.
Provided are genes having a key effect on isopentenyl chain cyclization and post-translational modification in biosynthesis of sesquiterpene polyketone compounds, and respectively named as myrD, myrF, myrJ, and myrK, and polypeptides encoded by the genes. Also provided is a use of the polypeptides in biosynthesis of the sesquiterpene polyketone compounds.
The present invention relates to a sesquiterpene polyketone compound that can be used as immunomodulator, or a pharmaceutical composition. An activity experiment shows that the sesquiterpene polyketone compound provided by the present invention can be used as an immunomodulator for preventing and/or treating immune-related diseases.
The present invention relates to use of a sesquiterpene polyketone compound and a salt thereof for preventing and treating pulmonary arterial hypertension. A biological activity experiment shows that the compound can reverse pulmonary vasculature reconstruction and is used for treating pulmonary arterial hypertension.
An external combined pressure-stage steam turbine set and an operating method therefor. A steam turbine generator set comprises a boiler (10), a high-pressure cylinder (11), and a first rotating shaft (12); a main steam valve (15) and a main path control valve (16) are sequentially arranged on a main steam pipeline along a steam flowing direction; a second rotating shaft (13), an energy conversion apparatus (14), and at least two adjustment pressure stages (21, 22, 23) are further comprised; the adjustment pressure stages (21, 22, 23) are connected in parallel, and then a steam inlet branch thereof is connected to an inlet end of the main path control valve (16), and a steam outlet branch thereof is connected to an outlet end of the main path control valve (16) by means of a bypass control valve (17); and each adjustment pressure stage (21, 22, 23) can be selectively turned on. By combining the adjustment pressure stages having different flow areas into multiple combination forms by using different connection modes, and then binding different combination forms with different load intervals one by one, under different load intervals, active adaption can be performed by switching to different external combined pressure stages, and a working link is gradually increased under a medium-low load working condition, thereby improving the adjustment capability of the generator set, and improving the operation energy efficiency.
F01K 7/22 - Steam engine plants characterised by the use of specific types of enginePlants or engines characterised by their use of special steam systems, cycles or processesControl means specially adapted for such systems, cycles or processesUse of withdrawn or exhaust steam for feed-water heating the engines being only of turbine type the turbines having inter-stage steam heating
F01K 11/02 - Steam engine plants characterised by the engines being structurally combined with boilers or condensers the engines being turbines
F01K 7/16 - Steam engine plants characterised by the use of specific types of enginePlants or engines characterised by their use of special steam systems, cycles or processesControl means specially adapted for such systems, cycles or processesUse of withdrawn or exhaust steam for feed-water heating the engines being only of turbine type
F01K 13/02 - Controlling, e.g. stopping or starting
F01D 15/10 - Adaptations for driving, or combinations with, electric generators
Disclosed in the present invention are intermediate I and intermediate II which have structural formulas as represented by formula (I) and formula (II), respectively, and can be used for preparing galantamine, and a preparation method therefor, and a method for the asymmetric total synthesis of galantamine and a derivative thereof with a short synthetic route and a high yield. According to the present invention, the intermediates required for the preparation of galantamine and the derivative thereof, i.e., the intermediates as represented by formula (I) and formula (II), are synthesized in sequence by means of using the simple, cheap and readily available compound 2, tert-butyl vinylcarbamate and 3-hydroxy-2-iodo-4-methoxybenzaldehyde as starting materials, and performing multiple reactions, such as a Suzuki cross-coupling reaction and a Mitsunobu reaction, and galantamine and the derivative thereof are then prepared by means of using the intermediates. The methods provided in the present invention for preparing galantamine, the derivative thereof and the intermediate thereof have a short synthesis route and a high yield, and large-scale production is easily achieved.
A preparation method for a nanostructured lipid carrier based on medium- and long-chain diglyceride embedded litsea cubeba essential oil and an application thereof in fruit and vegetable fresh-keeping. The preparation method comprises the following steps: using litsea cubeba essential oil, vegetable oil and medium- and long-chain diglyceride in a molten state as an oil phase; and then mixing an aqueous phase into the oil phase, carrying out high-speed shearing homogenization, carrying out ultrasonic treatment, and stirring and cooling in an ice bath to obtain the nanostructured lipid carrier based on medium- and long-chain diglyceride embedded litsea cubeba essential oil. The litsea cubeba essential oil embedded nanostructured lipid carrier has the advantages of small particle size, high encapsulation efficiency and good stability, and the problems that litsea cubeba essential oil is difficult to dissolve in water due to the oiliness thereof and is relatively difficult to utilize due to high volatility thereof are solved, so that efficient embedding and delayed release of litsea cubeba essential oil are realized, the broad-spectrum antibacterial property and the oxidation resistance of the litsea cubeba essential oil are fully exerted, the blueberry decay can be effectively inhibited, the shelf life of blueberries is prolonged, and the economic value is improved.
B65D 85/34 - Containers, packaging elements or packages, specially adapted for particular articles or materials for articles particularly sensitive to damage by shock or pressure for fruit, e.g. apples, oranges or tomatoes
B65D 81/24 - Adaptations for preventing deterioration or decay of contentsApplications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
50.
2-AMINOPYRIMIDINE COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF AND APPLICATION THEREOF
The present disclosure provides a class of 2-aminopyrimidine compounds with a structure shown in Formula (I) or their pharmaceutically acceptable salts, isotope derivatives, solvates, or their stereoisomers, geometric isomers, tautomers, or prodrug molecules or metabolites and pharmaceutical compositions and application thereof. The compounds of the present disclosure can efficiently and selectively inhibit the kinase activity of Janus Kinase 3 (JAK3), and have strong signal inhibition and cell proliferation inhibition effects on various blood tumor cells (especially human acute myeloid leukemia cell U937 cells) and solid tumor cells. They can be used to prepare anti-tumor drugs and drugs for preventing and treating inflammatory diseases.
The present disclosure provides a class of 2-aminopyrimidine compounds with a structure shown in Formula (I) or their pharmaceutically acceptable salts, isotope derivatives, solvates, or their stereoisomers, geometric isomers, tautomers, or prodrug molecules or metabolites and pharmaceutical compositions and application thereof. The compounds of the present disclosure can efficiently and selectively inhibit the kinase activity of Janus Kinase 3 (JAK3), and have strong signal inhibition and cell proliferation inhibition effects on various blood tumor cells (especially human acute myeloid leukemia cell U937 cells) and solid tumor cells. They can be used to prepare anti-tumor drugs and drugs for preventing and treating inflammatory diseases.
C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
The present invention relates to the technical field of perovskite solar cells. Disclosed are a perovskite material and an application thereof in a solar cell. The perovskite material is a perovskite material in which [Ag(I)TMA]+ions and Cs+2x1-x32x1-x1-yy32x1-x1-yy33. The perovskite material can be used as a perovskite absorption layer material of a perovskite type solar cell, and is used for preparing the perovskite type solar cell. The preparation method for the perovskite material is controllable in operation and has high reproducibility, and energy conversion efficiency and device stability of the perovskite type solar cell can be obviously improved when the perovskite material is applied to the solar cell.
H01L 51/42 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof specially adapted either for the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation
H01L 51/48 - Processes or apparatus specially adapted for the manufacture or treatment of such devices or of parts thereof
52.
LONG-DISTANCE REAL-TIME DISPLAY CAMERA COMMUNICATION SYSTEM AND METHOD
A long-distance real-time display camera communication system and method. The system comprises a concealed information input module, a display content input module, an LED display communication group modulation module, an LED display screen driving module, an LED display screen, a CMOS image sensor, and an image processing and information demodulation module; the concealed information input module and the display content input module are respectively connected to the LED display communication group modulation module; the LED display communication group modulation module modulates, in a grouping manner, signals to be transmitted to a plurality of adjacent light emitting chips of the LED display screen to emit visible light signals; the visible light signals are captured by the CMOS image sensor as image information within a preset range; the image information is transmitted to the image processing and information demodulation module connected to the CMOS image sensor for processing.
G09G 3/32 - Control arrangements or circuits, of interest only in connection with visual indicators other than cathode-ray tubes for presentation of an assembly of a number of characters, e.g. a page, by composing the assembly by combination of individual elements arranged in a matrix using controlled light sources using electroluminescent panels semiconductive, e.g. using light-emitting diodes [LED]
H04N 5/262 - Studio circuits, e.g. for mixing, switching-over, change of character of image, other special effects
53.
Method for constructing emergency reporting system of vehicle networking based on multi-signatures
Disclosed is a method for constructing an emergency reporting system of vehicle networking based on multi-signatures, which comprises the following steps: initializing an emergency reporting system to obtain a public-private key pair and pre-calculation parameters of a vehicle set; obtaining authentication information of the emergency based on the public-private key pair and the pre-calculation parameters; integrating the authentication information to obtain multi-signatures of the emergency; and completing the system construction by regulating a traffic state based on the multi-signatures. The method realizes the efficient signature generation function of the vehicle with limited computing resources, reduces the communication pressure and computing pressure of roadside units, and may effectively prevent the common rogue key attacks in other schemes.
H04L 9/32 - Arrangements for secret or secure communicationsNetwork security protocols including means for verifying the identity or authority of a user of the system
H04W 4/44 - Services specially adapted for particular environments, situations or purposes for vehicles, e.g. vehicle-to-pedestrians [V2P] for communication between vehicles and infrastructures, e.g. vehicle-to-cloud [V2C] or vehicle-to-home [V2H]
H04L 9/30 - Public key, i.e. encryption algorithm being computationally infeasible to invert and users' encryption keys not requiring secrecy
H04W 4/90 - Services for handling of emergency or hazardous situations, e.g. earthquake and tsunami warning systems [ETWS]
54.
TESTIS ORGANOID PREPARATION, CULTURE AND CRYOPRESERVATION RESUSCITATION METHODS AND APPLICATION
Provided are a cultured testis organoid, and preparation, culture and cryopreservation resuscitation methods therefor and an application thereof. The testis organoid can maintain specific functions of testes and can realize high-throughput drug screening.
A series auxiliary regulation-based steam turbine unit, a thermodynamic system and an operation method: multiple regulating pressure level groups (6) capable of using full-arc admission are connected in series in front of a conventional pressure level group (41), each regulating pressure level group (6) being provided with a corresponding regulating steam admission channel (10) to convey steam; different regulating pressure level groups (6) are commissioned according to different load intervals, and when the regulating pressure level groups (6) located upstream are commissioned, the regulating pressure level groups (6) located downstream are also commissioned to operate therewith due to the serial connection, so as to achieve the structural adaptability reconstruction of the steam turbine unit, increase the low-load efficiency of the unit, reduce the vibration amplitude, and construct different pressure-level structures merely by means of using length space of the unit along an axial direction. Under medium and low loads, the boiler flue temperature is low and there is a risk of denitration requirements not being met. Thus, a gas extraction pipeline is led out from a tail end of the regulating pressure level groups and connected to an adjustable heater, the water temperature at an admission end of a boiler is increased, and the flue temperature at a denitration site is adjusted according to actual needs, so that the denitration requirements are met.
A full-load efficient steam turbine unit, a thermodynamic system and an operation method. At least two steam channels (7) are arranged, in a radial direction, in an adjustment stage (6) at a front end of a high-pressure cylinder (4). When the thermodynamic system is in different load intervals, the thermodynamic system can be switched to corresponding steam channels (7) for operation, and different load working conditions are adapted by using steam flow capacities, which are not exactly the same, of different steam channels (7) and matching pressure stages, the numbers of which are not exactly the same, in the different steam channels (7), thereby ensuring relatively high cycle efficiency and relatively low system energy consumption under medium and low loads. A main steam valve (5) and an adjustment valve (51) arranged in a pipeline system are used to control the on/off of each steam channel (7). A multi-stage branch steam pipe network can also be provided, such that when a switch is made between the different steam channels (7), a smooth transition can be realized, thereby avoiding a sudden change in steam flow quantity. Under the medium and low loads, a steam extraction pipeline is led out from a tail end of the adjustment stage (6) so as to be connected to an adjustable heater (19), such that the water temperature at an inlet end of a boiler (1) is increased, and the gas temperature at a denitration position is adjusted according to actual requirements, thereby meeting a denitration requirement.
The present invention provides use of a non-hormone compound riluzole in the treatment of oligospermia, which provides beneficial help for solving the problem of male sterility and has a potential application prospect in the pharmaceutical field.
A61K 31/428 - Thiazoles condensed with carbocyclic rings
A61P 15/08 - Drugs for genital or sexual disordersContraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
58.
METHOD FOR PREPARING CODEINE AND DERIVATIVE AND INTERMEDIATE THEREOF
Disclosed are a method for preparing codeine and a derivative and intermediate thereof. Simple, cheap and easily-available commercially available compounds are used as starting materials in the present invention, various intermediates that are required for the preparation of codeine and a derivative thereof, i.e., intermediates shown in formulas (I) - (VI), are synthesized sequentially by means of various reactions such as Suzuki-Miyaura cross-coupling reaction, Mitsunobu reaction and Heck reaction, and then, codeine, deoxycodeine, norcodeine and other derivatives are prepared using these intermediates, respectively. The method for preparing codeine and a derivative and intermediate thereof provided by the present invention has a short synthesis route and high yield, and various intermediate compounds involved in the synthesis process all can be prepared on a gram scale.
C07C 271/08 - Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
C07C 269/06 - Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
C07D 307/77 - Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
C07D 489/02 - Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
The present invention provides a tricyclic fused heterocyclic compound having a structure represented by formula (I) or a pharmaceutically acceptable salt thereof or a stereoisomer thereof, a pharmaceutical composition thereof and use thereof. The compound and the pharmaceutically acceptable salt thereof to which the present invention relates can effectively inhibit the growth of various tumor cells, and can be used to prepare anti-tumor drugs.
A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
In a mass spectrometry method, a deuterium-resolved mass spectrum of a gas sample comprising volatile metabolites that have been excreted from a human or animal subject (50) after ingestion of deuterated water is determined. The deuterium-resolved mass spectrum to determine a presence or amount of at least one deuterated metabolite. Also disclosed is a corresponding mass spectrometry system.
A composition for preventing or treating osteoporosis, a preparation thereof, and use thereof in preventing or treating osteoporosis. The composition is mainly composed of a GPX4 agonist and a lipoxygenase 15(Alox-15) inhibitor, and cooperates with vitamin E to exert a synergistic effect. The GPX4 agonist comprises one or more of 6-gingerol, 8-gingerol, 10-gingerol and PKUMDL-LC-101-D04; the Alox-15 inhibitor comprises one or more of quercetin, ferulic acid, baicalein, hesperetin, nobiletin, PD146176, sinensetin and ML351; the composition comprises a ginger extract, a sea-buckthorn extract, and a wheat germ extract.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
Disclosed are a uniaxial crystal-based phase contrast microscopy module, device and method. The module comprises: a first polarizing plate, a second polarizing plate, and a uniaxial crystal arranged therebetween. Polarization states of the first polarizing plate and the second polarizing plate are orthogonal or parallel. The first polarizing plate is used for converting incident light carrying information of an object to be detected into linearly polarized light; the uniaxial crystal is used for enabling, on the basis of a photonic spin Hall effect and/or an angular dispersion effect, left-handed circularly polarized light and right-handed circularly polarized light generated by the linearly polarized light to generate displacements in opposite directions; and the second polarizing plate is used for performing sum or difference operation on a left-handed circularly polarized light field and a right-handed circularly polarized light field, so that when the displacements of the left-handed circularly polarized light and the right-handed circularly polarized light are much less than a spot size, a transmitted light field thereof is a first-order differential of the original incident light field. The present method can be used for edge enhancement of object strength information and visualization of object phase information. Compared with a traditional phase contrast microscopy technology, the present invention is more visual, convenient and time-saving.
Disclosed in the present invention are a living cell bionic corneal anterior lamellar and a preparation method therefor, comprising the following steps: A1, mixing corneal stromal cells and collagen, and preparing a bionic corneal stroma having ordered collagen; A2, arranging extracellular matrix proteins on the surface of the bionic corneal stroma; and A3, printing an epithelial cell spheroid, and culturing same to obtain a living cell bionic corneal anterior lamellar. According to the preparation method of the present invention, a living cell bionic corneal anterior lamellar containing a biological material can be constructed by combining a bionic platform and 3D bioprinting technology; the preparation method is simple, convenient and efficient, and the prepared living cell bionic corneal anterior lamellar has a structure and a physiological function similar to those of a natural cornea, has good biocompatibility and repairing effect, can effectively repair a damaged cornea tissue, and is expected to be used for constructing a natural cornea substitute to treat diseases such as corneal blindness.
Provided is a use of C. minuta in preparation of a medication for treating and/or preventing hyperuricemia-related diseases. A model mouse is used as a study object, and a control group, a model group, and a C. minuta group are set to study the effect of C. minuta in lowering body serum uric acid. The result shows that C. minuta can significantly inhibit the value of serum uric acid in a mouse of the C. minuta group, and the C. minuta group is significantly different from the model group, indicating that C. minuta has an obvious uric acid lowering effect and can mitigate symptoms such as hyperuricemia and gout diseases.
The present invention provides a preparation method for a large-area nanodisk. The method comprises: preparing a polystyrene microsphere colloidal solution, and spin-coating and dispersing the colloidal solution onto a clean substrate; selecting different angles from which to deposit a layer of a metal thin film onto the surface of the polystyrene microsphere substrate; carrying out a microsphere removal treatment on the polystyrene microsphere substrate with the layer of the metal thin film deposited thereon, depositing a layer of a material thin film onto the surface of the metal hole thin film, and then stripping the layer of the material thin film from the layer of the metal thin film to obtain a first nanodisk structure; directly depositing another layer of the material thin film onto the surface of the polystyrene microsphere substrate with the layer of the metal thin film deposited thereon, and then stripping the layer of the material thin film from the layer of the metal thin film to obtain a second nanodisk structure. Compared with the existing electron beam photoetching and focused ion beam etching methods, the preparation method does not need the dry etching process required by the traditional nanodisk preparation methods, so that the preparation efficiency of the nanodisk structure is greatly improved, and the preparation cost is reduced.
The present disclosure relates to the field of medicine, and specifically to the use of a new-type securinine dimer or a pharmaceutically acceptable salt thereof in the preparation of a drug for treating Alzheimer's disease. The new-type securinine dimer has a structural formula as shown in general formula (I) or a pharmaceutically acceptable salt thereof or a stereoisomer thereof or a prodrug molecule thereof. In the formula, the linking group Linker is selected from formula (A) or formula (B), wherein X is selected from formula (II) or formula (III), and n is 1, 2, 3 or 4.
C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
A61K 31/439 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
67.
ANTIOXIDANT EDIBLE OIL BASED ON NANO REVERSE MICELLAR SYSTEM AND PREPARATION METHOD THEREFOR
An antioxidant edible oil based on a nano reverse micellar system, comprising the following components: 22.5-100 parts by mass of vegetable oil rich in unsaturated fatty acid, 0.5-6 parts by mass of edible emulsifier, and 3.75-10 parts by mass of natural plant dry material. A preparation method for the antioxidant edible oil based on the nano reverse micellar system, comprising the following steps: step (1): uniformly mixing the vegetable oil and the edible emulsifier, and stirring and dissolving until the system is stable, so as to obtain a vegetable oil-edible emulsifier compound oil sample; and step (2): adding the natural plant dry material into the vegetable oil-edible emulsifier compound oil sample obtained in step (1), extracting antioxidant components in a natural plant raw material, and then centrifuging, so as to obtain the antioxidant edible oil.
A dynamically-reconfigurable steam turbine generator set. The steam turbine generator set comprises a high-voltage compensation pressure stage (9) and/or a medium-voltage compensation pressure stage (8); an operation load working condition of the steam turbine set is firstly determined; under a high-load working condition, a regular high-pressure cylinder (3) and a regular medium-pressure cylinder (4) are put into operation, and the high-voltage compensation pressure stage (9) and/or the medium-voltage compensation pressure stage (8) idles or stops; under a low-load working condition, the high-voltage compensation pressure stage (9) operates in series with the high-pressure cylinder (3), and/or the medium-voltage compensation pressure stage (8) operates in series with the medium-pressure cylinder (4). Pressures stages are connected in series in a throughflow system, a working link is added, and a high set operation pressure is maintained by means of pressure transmission. Depending on the operation load working condition, a throughflow state of the steam turbine set is dynamically reconfigured, thereby avoiding the problem that energy efficiency is sharply reduced due to the fact that the operation pressure of main reheated steam is reduced under a medium/low load working condition of the steam turbine set, and improving the working condition adaptability of the steam turbine set. Also provided is an operation method.
F01K 7/22 - Steam engine plants characterised by the use of specific types of enginePlants or engines characterised by their use of special steam systems, cycles or processesControl means specially adapted for such systems, cycles or processesUse of withdrawn or exhaust steam for feed-water heating the engines being only of turbine type the turbines having inter-stage steam heating
F01K 11/02 - Steam engine plants characterised by the engines being structurally combined with boilers or condensers the engines being turbines
69.
USE OF INDACATEROL MALEATE AS CGAS-STING PATHWAY TARGETED AGONIST
Provided is the use of indacaterol maleate as a cGAS-STING pathway targeted agonist. By means of in-vitro level verification and biotin photoaffinity labeling combined with proteomics, bioinformatics and molecular biology, the results show that indacaterol maleate can target and activate a cGAS-STING pathway, inhibits cancer cell proliferation, and has good therapeutic prospects for the adjuvant treatment of colorectal cancer-related diseases.
The present invention relates to the technical field of medicines, and in particular to a use of brevilin in preparation of a Rab5 protein inhibitor. In the present invention, by using various instruments and methods such as a fluorescence titration experiment, an isothermal titration calorimeter, and a circular dichroism spectrometer, it is proved that brevilin and Rab5 can interact with each other. In the present invention, a molecular docking condition between brevilin and Rab5 protein is further simulated to obtain potential interaction sites. On the basis of the finding that brevilin can be used to obtain action sites of Rab5 protein in the present invention, brevilin can be used in synthesis of compounds having similar structures and research of drugs, and can also be used to screen for compounds capable of acting on the action sites to provide new ideas for design of anti-tumor drugs. By means of the finding that brevilin can be used as an inhibitor of Rab5 protein in the present invention, the effect of inhibiting tumor formation and development can be achieved, and the finding in the present invention has a good prospect in respect of treatment of Rab5 protein related diseases and screening of related drugs.
Disclosed in the present invention are a new polypeptide for promoting tissue repair, and the use thereof. The new polypeptide can promote the proliferation of human immortalized epidermal cells and the migration of human epidermal fibroblasts at a relatively low concentration, can promote the repair of wounds and ulcers, improves the aesthetic feeling of the skin, has low toxic side effects, has good application prospects, and can be used for preparing a drug and a medical instrument for treating wound surfaces, scalds and ulcers or for preparing an everyday chemical for improving the aesthetic feeling of the skin.
A61K 38/16 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof
A61K 8/64 - ProteinsPeptidesDerivatives or degradation products thereof
A61P 1/02 - Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
A61P 1/04 - Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Provided is a Lactobacillus plantarum strain and an application thereof in the biotransformation of secoisolariciresinol diglucoside (SDG), relating to the technical field of food microorganisms. The bacterium is called Lactobacillus plantarum FCC5 and has an accession number of GDMCC NO: 61973. The Lactobacillus plantarum FCC5 comes from a conventional fermented soybean product, shows a high survival rate in gastrointestinal fluid in in-vitro experiments, is safe and non-hemolytic, has a good application prospect in food, and also has a transformation function of performing deglucosidation, demethylation and dehydroxylation on SDG to obtain an SDG metabolic mixture, thereby improving bioavailability of SDG. The FCC5 features high transformation efficiency in whole-cell catalytic transformation of SDG and a simple reaction system; and the whole-cell transformation product is a mixture of a lignan and a live probiotic, has dual effects of the live probiotic and the lignan, is safe and simple in ingredients, and thus can be directly added into food.
A 5-formyl heterocyclic amide compound and a use thereof, said class of compound having a structure represented by formula (I) or a pharmaceutically acceptable salt, stereoisomer or prodrug molecule thereof. Said class of compound has FGFR4 inhibitory activity, and may be used to prevent or treat diseases related to abnormal FGFR4 activity such as fusion or overexpression, such as liver cancer, bile duct cancer, breast cancer, gastric cancer and prostate cancer, and may also be used in combination with other drugs and used in anti-tumor and anticancer drugs.
A61K 31/4375 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring hetero atom, e.g. quinolizines, naphthyridines, berberine, vincamine
A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (China)
Inventor
Ding, Ke
Ding, Jian
Chen, Hao
Xie, Hua
Lu, Xiao Yun
Zhang, Tao
Ren, Xiao Mei
Tong, Lin Jiang
Abstract
Disclosed are a cyclic 2-aminopyrimidine compound having a structure represented by formula (1), or a pharmaceutically acceptable salt or a stereoisomer or a prodrug molecule thereof, and an application thereof. The disclosed compound can effectively inhibit the activity of EGFR protein kinase drug-resistant mutants (such as EGFRT790Mand EGFR19del/T790M/C797S), and can overcome clinical drug resistance in tumor patients suffering from non-small cell lung cancer, etc., induced by existing third-generation selective EGFRT790M small-molecule inhibitors such as Osimertinib (AZD9291), Olmutinib (HM6171), and Rociletinib (CO-1686).
C07D 403/04 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
Disclosed are a novel coronavirus protein antigen nanovaccine, a preparation method therefor and an application thereof. The preparation method comprises: respectively dissolving lentinan, sodium selenite and vitamin C in high pressure sterilized water to respectively prepare a lentinan stock solution, a sodium selenite stock solution and a vitamin C stock solution; adding RBD into the sodium selenite stock solution and stirring, adding the mixture into the lentinan stock solution and continuing to stir, then adding the resulting mixture into high-pressure sterilized water and stirring to enable the polymer to be fully and uniformly mixed with the RBD and the sodium selenite, so as to form a mixed solution; and dropwise adding the vitamin C stock solution into the mixed solution, stirring at low temperature after dropwise adding, and finally putting the solution obtained after reaction into a dialysis bag to obtain a novel coronavirus protein antigen nanovaccine. According to the present invention, by utilizing the advantages of a nano-selenium carrier to load RBD for effective presentation, the immunogenicity of the RBD vaccine is improved, and the body is induced to produce a potent immune response.
A61K 33/04 - Sulfur, selenium or telluriumCompounds thereof
A61K 31/715 - Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkagesDerivatives thereof, e.g. ethers, esters
The present invention relates to a selenium-doped hydroxyapatite nano-enhanced collagen GBR film and a preparation method therefor. The preparation method comprises the steps of: (1) preparing selenium-doped hydroxyapatite (Se-HAP), synthesizing a Se-HAP nanostructure from Se/(Se+P) by means of a solvothermal method; and (2) adding animal skin collagen into an acetic acid solution and stirring to prepare a collagen solution, mechanically stirring until completely dissolved, and uniformly dispersing the collagen by using an intermittent low-temperature ultrasonic mode; adding Se-HAP nanowire powder into an aqueous solution, sufficiently stirring to prepare a Se-HAP slurry, uniformly mixing the collagen solution with the Se-HAP slurry to obtain a collagen/Se-HAP mixture solution that undergoes ultrasonic treatment, then carrying out centrifugal treatment on the concentrated collagen solution, placing same on a cooling device and cooling the collagen solution to 0°C or lower, and carrying out freeze drying to obtain the selenium-doped hydroxyapatite nanowire-enhanced collagen GBR film, which can be applied to medical rehabilitation for guided bone regeneration and has antibacterial properties and excellent performance in promoting bone differentiation and regeneration.
Disclosed in the present invention is an application of a polycyclic polyketide compound in the preparation of an anti-SARS-CoV-2 drug. The polyketide compound discovered in the present invention has an inhibition effect on SARS-CoV-2 at a cellular level, can significantly reduce the toxicity of the virus in cells, inhibits virus-induced cytopathy, and is concentration-dependent. In addition, the polyketide compound has a different chemical structure type from remdesivir and chloroquine phosphate, and is expected to develop into a novel anti-SARS-CoV-2 drug. Therefore, such a compound has good application prospects in the treatment of related diseases caused by SARS-CoV-2 infection.
A61K 31/352 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
The present invention relates to the technical field of active substance development, and especially relates to the use of Fructus lycii glucopeptide. In the present invention, the protection effect of the Fructus lycii glucopeptide on Parkinson-like dyskinesia is studied by means of using a Parkinson's disease animal model as a study object. The result shows that the Fructus lycii glucopeptide can improve the Parkinson-like dyskinesia of the model animal.
A simulated surgery guidance method based on a three-dimensional heart model, relating to the field of medical teaching. An animal heart is used as a simulation material of a surgery, a three-dimensional virtual heart model is constructed, the boundary of a surgery incision is rapidly determined according to surgery requirements and in combination with image processing technology, and parameters such as a maximum diameter and a minimum diameter of the surgery incision are obtained, so that reference is provided for subsequent installation and entrance of assisting instruments, and the success rate of surgical operation is improved. The present invention further provides a corresponding simulated surgery guidance apparatus (20) and device (30) and a storage medium (32). Therefore, effective operation assistance can be provided for a heart surgery, the safety and intuition of a surgery teaching process are improved, and the teaching effect of heart surgery teaching is facilitated to improve.
Disclosed are a VR-based cardiac surgery simulation method and apparatus. The method comprises: receiving an operation instruction transmitted by a user, the operation instruction comprising a surgical operation instruction and/or a medication instruction; generating a real-time surgical response picture according to the operation instruction, a preset response rule, and a cardiac three-dimensional model, the surgical response picture being configured to be displayed to the user by means of a VR wearable device; and determining whether the operation instruction meets a preset safety rule, and if not, generating an error prompt picture, the error prompt picture being configured to be displayed to the user by means of the VR wearable device. Hence, in the present invention, the cardiac surgery can be simulated by means of the VR technology, and the operation safety of the user is determined, thereby realizing a more vivid cardiac surgery simulation effect, facilitating correction of an error of the user in the cardiac simulation surgery, and further improving the training effect of physician training by means of the present invention.
The present invention relates to a pharmaceutical composition for preventing and/or treating neurodegenerative diseases. On the one hand, the active ingredient C21 steroid saponin of the pharmaceutical composition can significantly reduce the generation of an amyloid β-protein in N2a-APP695 cells and increase the clearance of excess Aβ; and on the other hand, the active ingredient C21 steroid saponin of the pharmaceutical composition can promote the proliferation of neuron cells, and has a protective effect on the neuronal cytotoxicity induced by neurotransmitters such as glutamate caused by the excessive accumulation of Aβ, thereby comprehensively playing a role in the treatment of neurodegenerative diseases. Therefore, the pharmaceutical composition has good application prospects in the preparation of an Aβ formation inhibitor and a neuroprotective agent, and in drugs for preventing or treating neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and Huntington's disease.
A61K 31/57 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
A61K 36/27 - Asclepiadaceae (Milkweed family), e.g. hoya
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
An optical fiber connector, and a preparation method for an optical fiber ferrule. The connector comprises: a first optical fiber connecting head, a second optical fiber connecting head and an adapter pair, wherein the first optical fiber connecting head comprises a first optical fiber ferrule having a central axis through-hole structure, and a first optical fiber can pass through the first optical fiber ferrule; the second optical fiber connecting head comprises a second optical fiber ferrule having a central axis through-hole structure, and a second optical fiber can pass through the second optical fiber ferrule; two adapters in the adapter pair are used for connecting the first optical fiber and the second optical fiber in the adapter pair; the head of the first optical fiber ferrule comprises a first optical fiber limiting structure for fixing the head of the first optical fiber in the first optical fiber ferrule; and/or the head of the second optical fiber ferrule comprises a second optical fiber limiting structure for fixing the head of the second optical fiber in the second optical fiber ferrule, thereby reducing the connection loss of the optical fibers and improving the coupling efficiency.
The use of octenidine dihydrochloride (OCT) in the preparation of an antitumor drug. The octenidine dihydrochloride can inhibit the growth and proliferation of nasopharyngeal carcinoma cells, can obviously inhibit in-vivo subcutaneous tumorigenesis in nude mice, has good safety, and can be used for preparing a drug for treating tumors such as nasopharyngeal carcinoma, esophageal squamous cell carcinoma, colorectal cancer or lung cancer.
A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
A cyclone separation device, comprising an inner barrel (1), wherein a gas inlet (2) is provided in a peripheral face of the inner barrel (1) in a tangent direction, and a gas output pipe (3) is arranged at the top of the inner barrel (1). The cyclone separation device further comprises an outer barrel (5), wherein the inner barrel (1) is arranged in the outer barrel (5); an outer wall of the inner barrel (1) is a filter screen (4) for liquid-solid separation; a cavity (6) is formed between the outer wall of the inner barrel (1) and an inner side wall of the outer barrel (5); and the cavity (6) is internally provided with a purging device for blowing off solids on the filter screen (4) into a hollow cavity arranged in the inner barrel (1). After gas mixed with solid particles and liquid enter the inner barrel (1), the liquid passes through the filter screen (4) and enters the outer barrel (5), most of the solid particles blocked by the filter screen (4) fall into the inner barrel (1), a small amount of same are adhered to the filter screen (4), the purging device can gradually blow off the solid particles attached to the filter screen (4) to the bottom of the inner barrel (1), and the incoming gas is discharged by means of a gas output pipe (3), thereby separating a gas-liquid-solid three-phase mixture.
The invention discloses a microlens and an application thereof, wherein the microlens is a lipid particle. The microlens prepared by the invention is simple in preparation and extraction methods, and does not need extra processing. The lipid particle is capable of serving as an optical element inside a cell to exert an optical function and has a complete biocompatibility; and meanwhile, the lipid particle is naturally generated inside the cell, and has a natural position-close relationship with a microstructure inside the cell, and is capable of collecting and re-positioning an optical signal of the microstructure in a near field, so that an imaging quality of the cell microstructure of an optical microscope is effectively improved.
G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes
G02B 21/16 - Microscopes adapted for ultraviolet illumination
C12P 7/64 - FatsFatty oilsEster-type waxesHigher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl groupOxidised oils or fats
86.
SUBCRITICAL COMPOSITE SOLVENT EXTRACTION AND SEPARATION METHOD FOR MULTIPLE COMPONENTS IN FLAXSEED MEAL
Disclosed is a subcritical composite solvent extraction and separation method for multiple components in flaxseed meal, comprising the following steps: taking flaxseed meal, and adding an extractant for subcritical extraction to obtain a crude flax lignan extract and flaxseed crude oil in one step, wherein the extractant is composed of n-butane and absolute ethanol at a volume ratio of 1:1; adding n-hexane to the flaxseed crude oil to carry out liquid separation extraction, so that flaxseed oil may be obtained after rotary evaporation; and taking the used flaxseed meal for hot water extraction to obtain flaxseed gel. The subcritical composite solvent used in the extraction process of the present invention may replace a large number of organic reagents used in traditional extraction, has the characteristics of a good solvent effect, environmental-friendliness and recyclability, a low environmental burden, etc., and may reduce the risk of harm to operators and the natural environment during the process caused by organic reagents. Moreover, the subcritical extraction in the present invention has lower requirements for operations and professionals, and obtains a variety of high value-added components while reducing operation units, which maximizes resource utilization, reduces costs and increases efficiency.
Disclosed in the present invention are a method for analyzing a targeted exposure group of environmental pollutants in blood plasma, and the use thereof. The method comprises the following steps: (1) adding a recovery indicator to plasma to obtain a mixture of the plasma and the recovery indicator; (2) adding a mixed solvent of ethyl acetate and n-hexane that contains formic acid to perform extraction, then adding ethyl acetate to perform extraction, and combining extraction solutions; (3) performing blow-drying on the extraction solution using nitrogen, then adding methanol for redissolution, then freezing and centrifuging same, and taking a supernatant to obtain a pretreated sample; (4) adding an internal standard to the pretreated sample, and then performing quantitative analysis on environmental pollutants by means of using a liquid chromatography-tandem mass spectrometry and/or a gas chromatography-tandem mass spectrometry. The method in the present invention can realize the simultaneous detection of hundreds of different types of environmental pollutants in plasma, has a simple and convenient processing method, a short analysis time and is low cost, and can maximize analytical efficiency.
Disclosed in the present invention is the use of Crassifolin A in promoting mitophagy and treating neurodegenerative diseases. According to the present invention, experiments show that the diterpene compound Crassifolin A can significantly increase mitophagy levels, promote the removal of damaged mitochondria, maintain homeostasis in cells, and has potential effects of treating neurodegenerative diseases and other related diseases; moreover, Crassifolin A is a small-molecule compound that can easily penetrate through the blood-brain barrier to reach the brain so as to play a role, can be extracted from a Thickleaf croton root medicinal material, has the advantages of abundant medicinal sources, easy availability, low drug toxicity and few side effects, and has a good application prospect in the treatment of neurodegenerative diseases.
A61K 36/47 - Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 25/14 - Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
A61P 25/00 - Drugs for disorders of the nervous system
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
The present disclosure relates to an application of miR-31-5p in acute myeloid leukemia (AML), particularly, a use of a product for detecting the miR-31-5p in preparation of a reagent, chip, or reagent kit for auxiliary diagnosis of a subject suffering from the AML and/or for prognosis of survival time of the subject, and a use of a miR-31 primary/precursor miRNA (pri/pre-miR-31) and/or a miR-31 mature miRNA (miR-31-5p) in preparation of a drug for treatment of the AML. Introduction of the miR-31-5p into cells by means of gene transduction can induce cell death of bone marrow AML cells and AML leukemic stem cells (AML-LSCs) and enhance the cytotoxicity of cytosine arabinoside as a chemotherapeutic drug, and expression of the miR-31-5p can inhibit the growth of the AML cells and the AML-LSCs, and prolong the lifetime of animals. The present disclosure provides a novel method for AML diagnosis and prognostic assessment, and further provides a gene therapeutic drug for the AML.
C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
A multi-component and high-throughput analysis method for plastic additives. The analysis method comprises the following steps: (1) a sample to be detected and a recovery indicator are mixed uniformly; (2) a tetrahydrofuran solution containing aqueous ammonia is added to the mixed solution obtained in step (1), which is stirred, mixed and subject to ultrasonic treatment until completely mixed; (3) an aqueous methanol solution is added to the mixed solution obtained in step (2), which is mixed uniformly, stirred, centrifuged, concentrated and filtered; (4) an internal standard is added to the filtrate obtained in step (3); and (5) the sample obtained in step (4) is quantitatively analyzed by means of an ultra-performance liquid chromatography tandem mass spectrometer. The analysis method can simultaneously detect plastic additives of different structures and uses in lipstick and nail polish, and improve the analysis efficiency by shortening the analysis time and reducing the analysis cost.
An electrode material, its manufacturing method, and its use as a cathode material in batteries are provided. The electrode material comprises a plurality of nanoparticles, each having a diameter of approximately 100-400 nm and comprising a core and a shell encapsulating the core. The shell comprises carbon and nitrogen, respectively having a mass fraction of approximately 70-90% and approximately 5-20% relative to a total mass of the shell. The core comprises sulfur, having a mass fraction of approximately 40-97% relative to a total mass of the core. The core has a mass fraction of approximately 50-90% relative to a total mass of each nanoparticle. The electrode material can be used in a cathode of a Li—S battery, which has a good energy storage capacity, a high electrochemical stability, and a low capacity decay.
H01M 4/36 - Selection of substances as active materials, active masses, active liquids
H01M 4/587 - Carbonaceous material, e.g. graphite-intercalation compounds or CFx for inserting or intercalating light metals
H01M 4/58 - Selection of substances as active materials, active masses, active liquids of inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFySelection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates
H01M 4/62 - Selection of inactive substances as ingredients for active masses, e.g. binders, fillers
A social recommendation method based on a multi-feature heterogeneous graph neural network is provided and includes: extracting attribute information of users and topics to code; processing user coding information and topic coding information through a multi-layer perceptron to obtain initial feature vectors of the users and the topics; establishing a heterogeneous graph by taking the users and the topics as nodes; inputting the heterogeneous graph into a heterogeneous graph neural network to perform information transmission in combination with an attention mechanism, and updating the feature vectors; and performing similarity calculation on the feature vectors of the users, and selecting the user and the topic with the highest similarity with the feature vector of the user for recommendation. Social information can be mined more comprehensively, features of users and interested topics of the users can be deeply fused, and recommendation accuracy and user experience can be improved.
G06Q 50/00 - Information and communication technology [ICT] specially adapted for implementation of business processes of specific business sectors, e.g. utilities or tourism
G06N 3/063 - Physical realisation, i.e. hardware implementation of neural networks, neurons or parts of neurons using electronic means
93.
RADIAL CAVITY QUARTZ-ENHANCED PHOTOACOUSTIC SPECTROPHONE AND GAS DETECTION DEVICE COMPRISING SAME
A photoacoustic spectrophone (5) and a gas detection device comprising the photoacoustic spectrophone (5). The photoacoustic spectrophone (5) comprises: a cylindrical barrel (50), which has a central axis (A1) and a symmetry line (A2) perpendicular to the central axis (A1); an incident window (51), which is arranged at an inlet end of the cylindrical barrel (50); a light-transmitting emergent window (52), which is arranged at an outlet end of the cylindrical barrel (50); a gas inlet (53) and a gas outlet (54), which are arranged on the outer wall of the cylindrical barrel (50); a radial-cavity gas chamber (56), which is sealed between the incident window (51) and the emergent window (52); and a quartz tuning fork (55), which is fixedly arranged in the radial-cavity gas chamber (56), wherein the symmetry line (A2) of the cylindrical barrel (50) penetrates a quartz tuning fork base along the middle of a gap between two fork arms of the quartz tuning fork (55), and the central axis (A1) of the cylindrical barrel (50) passes through the gap between the two fork arms of the quartz tuning fork (55). The radial resonance mode has a low requirement for the length of a resonant cavity, such that beam collimation is more convenient; a strong radial resonance mode greatly enhances an output signal; and a radial cavity is used as a resonant cavity and a gas chamber at the same time, thereby simplifying the structure and reducing the volume.
A text sentiment analysis method based on multi-level graph pooling includes steps of: preprocessing a target text; taking collocate point mutual information between word nodes as an edge weight between the word nodes, and building a graph for each text independently; constructing a multi-level graph pooling model, of which a gated graph neural network layer transfers low-level information, a first graph self-attention pooling layer performs an initial graph pooling operation and uses a Readout function to extract low-level features, a second graph self-attention pooling layer performs a graph pooling operation again, performs a pruning update on the graph structure by calculating attention scores of nodes in the graph and uses a Readout function to extract high-level features; obtaining a multi-level final vector representation through a feature fusion function; and selecting a sentiment category corresponding to a maximum probability value as a final sentiment category output of the text.
Disclosed in the present invention are a DMD-based method, apparatus and system for generating a multi-parameter adjustable light field. The method comprises: performing beam expansion and collimation processing on a femtosecond laser beam, determining a laser beam after beam expansion and collimation; filtering the laser beam, determining a first filtered laser beam; performing dispersion compensation processing on a first filtered laser beam, determining a dispersion-compensated laser beam; combining a complex amplitude expression of a target light field and a binary holographic algorithm, determining a binary hologram of the target light field; loading the binary hologram to a DMD and performing wavefront modulation on the dispersion-compensated laser beam by means of the DMD, determining a modulated laser beam; filtering the modulated laser beam to filter out zero-order diffracted light and negative first-order diffracted light, determining first-order diffracted light passing through; and performing focusing processing on the first-order diffracted light, generating a multi-parameter adjustable array light field. The present invention can reduce use costs of a system, and can be widely used in the technical field of light field regulation and control.
G02B 26/06 - Optical devices or arrangements for the control of light using movable or deformable optical elements for controlling the phase of light
G03H 1/00 - Holographic processes or apparatus using light, infrared, or ultraviolet waves for obtaining holograms or for obtaining an image from themDetails peculiar thereto
A fiber-optic sensing apparatus is provided, including an outer sleeve, an optical fiber sensor arranged within the outer sleeve, and a filling medium. The optical fiber sensor is capable of detecting a change of a refractive index or a change of surface plasmon waves over an outer surface of the outer sleeve. The filling medium may have a matching refractive index with the outer sleeve and with the optical fiber sensor. The outer sleeve may be exposed directly to the outside medium, or may be coated with at least one functional film layer such as a surface plasmon resonance (SPR)-active base film layer, or a reactive film layer that is reactive to a target molecule in the outside medium.
A fiber-optic sensing apparatus, system, and method for characterizing at least one metal ion in a solution are provided. The sensing apparatus includes a fiber-optic sensor and a controller. The sensor includes an optical fiber with tilted grating in its core, and includes a conductive and surface plasmon resonance (SPR)-active coating assembly that allows the sensor to also serve as an electrochemical working electrode. The controller is electrically connected with the sensor, configured to provide an adjustable potential such that when the coating assembly is in contact with the solution, redox reactions of each of the at least one metal ion occur on an outer surface thereof, resulting in a detectable change of the surface plasmon waves generated in the fiber-optic sensor. Based on the change thus detected, identities and/or concentration of the at least one metal ion in the solution can be determined with high accuracy and sensitivity.
114121431445141466 is independently selected from carbonyl, hydroxy or hydrogen. The bisindole alkaloid compound of the present invention can selectively relax the pulmonary artery, inhibit the proliferation of pulmonary arterial endothelial cells and vascular smooth muscle cells, and reduce the right ventricular diastolic pressure in a mouse with pulmonary hypertension and inhibit the right ventricular hypertrophy thereof. The bisindole alkaloid compound of the present invention can resist drug addiction in a dose-dependent manner, is of a chemical structure type different from existing anti-addiction drugs, and is expected to be developed into a new anti-addiction drug.
C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or
A61K 31/55 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
Provided are a drug and method for treating temporal lobe epilepsy (TLE) in a subject, the method comprising: administering a nucleic acid encoding NeuroD1 polypeptides to glial cells in the hippocampus region of the subject, so that the glial cells express NeuroD1 polypeptides and are transformed into GABAergic neurons. Also provided are a drug and method for forming GABAergic neurons in the hippocampus region of a living mammalian brain, the method comprising: administering a nucleic acid encoding NeuroD1 polypeptides to glial cells located in the hippocampus region, so that the glial cells express NeuroD1 polypeptides and are transformed into GABAergic neurons.
A dual-pulse excitation method for ultra-fast, super-resolution all-optical magnetic recording includes the steps of: providing a first excitation pulse and a second modulation pulse; and focusing the first excitation pulse and the second modulation pulse, and then radiating the two pulses in sequence to a magneto-optical recording medium, so that an area of the magneto-optical recording medium irradiated undergoes opto-magnetic reversal. By controlling the time delay, spatial overlapping area, and energy density ratio between the dual femtosecond laser pulses, it can induce a second reversal of the magnetization field in the spatial overlapping area of the two pulses on the magneto-optical material that can achieve single-pulse opto-magnetic reversal to obtain all-optical magnetic recording beyond the diffraction limit. This process takes place within several hundred picoseconds, thus providing an effective technical means for ultra-high density and ultra-fast magnetic storage.
G11B 13/04 - Recording simultaneously or selectively by methods or means covered by different main groupsRecord carriers thereforReproducing simultaneously or selectively therefrom magnetically and optically
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