THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
Inventor
Badwan, Adnan
Al-Remawi, Mayyas
Abstract
The present invention relates to a solid pharmaceutical formulation comprising at least one hydrophilic water-soluble superdisintegrating oligo-polymer having a molecular weight in the range of 200-3000 Da and having from 3 to 20 monomeric repeating units forming the oligo-polymer as matrix and at least one active agent dispersed throughout the matrix, wherein the oligo-polymer simultaneously dissolves and disintegrates in a liquid.
THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
Inventor
Badwan, Adnan
Al-Remawi, Mayyas
Said Rashid, Iyad
Abstract
A mineral-fiber solid dispersion comprising at least one hydrophilic polymeric material selected from the group consisting of hydrophilic polysaccharides having the ability to form a gel in water with minimal dissolution nature, and at least one silica-based trivalent or divalent salt of a water-absorbable compound selected from the group consisting of silicon dioxide, derivatives thereof or any mixtures thereof is described in this invention. Also a method for preparing the mineral-fiber solid dispersion, wherein the method in conducted via a solid-in-solid dispersion technique which comprises mixing the fiber material with the water-absorbable compound in a presence of water and allowing the absorption of the water- absorbable compound in an appropriate ratio in the intimate structure of the fiber material, and next adjusting the process conditions in order to allow the precipitation of the water-absorbable compound into the mineral solid within the structure of the fiber material to form a solid-in-solid dispersion of mineral and fiber is described. The mineral-fiber solid dispersion is used for manufacturing of multifunctional pharmaceutical filler or direct compressible excipient that can be used as a pharmaceutical tableting aid possessing powerful compaction, disintegration and flow properties.
THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
Inventor
Badwan, Adnan
Al-Remawi, Mayyas
Abstract
The present invention relates to a composition comprising an aqueous solvent and a conjugate of at least one hydrophilic polymer having a primary amine functional group, a derivative or monomer thereof and at least one acidic drug; a method for its preparation and use thereof.
A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
4.
COMPOSITION COMPRISING COVALENT CONJUGATES OF CHITOSAN AND AN ACIDIC DRUG FOR PARENTERAL ADMINISTRATION
THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
Inventor
Badwan, Adnan
Al Remawi, Mayyas
Abstract
The present invention relates to a composition comprising an aqueous solvent and a conjugate of at least one hydrophilic polymer having a primary amine functional group, a derivative or monomer thereof and at least one acidic drug; a method for its preparation and use thereof.
A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
5.
COMPOSITION COMPRISING CHITOSAN AND AN ACIDIC DRUG FOR ORAL CONTROLLED RELEASE
THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
Inventor
Al-Remawi, Mayyas
Badwan, Adnan
Abstract
The present invention relates to a composition comprising an aqueous solvent and a conjugate of at least one hydrophilic polymer having a primary amine functional group, a derivative or monomer thereof and at least one acidic drug; a method for its preparation and use thereof.
A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
Inventor
Badwan, Adnan
Ginna, Nidal, Adel
Taha, Hashem
Abstract
The present invention relates to a combination of herbal extracts to treat male sexual dysfunction. More precisely, the present invention relates to a combination of five different herbal extracts including Ginseng extract, Tongkat AIi extract, Epimedium extract, Gotu Kola extract and flower pollen extract to restore male erectile function. The composition has a promoting effect on penile erectility, so that it can be effectively used for the improvement of erectile dysfunction.
THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
Inventor
Badwan, Adnan
Al-Remawi, Mayyas
Rashid, Lyad, Said
Abstract
The invention relates to a co-precipitate comprising at least one hydrophilic polymeric compound selected from the group consisting of xanthan gum, sodium alginate, propylene glycol alginate, pectin, guar gum, cellulose, sodium carboxymethyl cellulose, hydroxymethyl propyl cellulose, methyl cellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, cyclodextrins, tragacanth, locust bean gum, carrageenan, polydextrose, dextrin, maltodextrin, polyethylene glycol, polyethylene oxide, polyvinyl alcohol, povidone, microcrystalline cellulose, croscarmellose sodium, calcium carboxymethyl cellulose, crospovidone, alginic acid and docosate sodium, or any other salts, solvates, derivatives or mixtures thereof, and at least one water-absorbable compound selected from the group consisting silicon dioxide, derivatives thereof, or any mixtures thereof; a method of preparing the same and uses thereof.
THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
Inventor
Badwan, Adnan
Mohammed, Murshed, Abdel-Qader
Abstract
The present invention refers to positively charged water-soluble chitosan, preferably chitosan oligosaccharide, used as a membrane-blocking agent in the manufacture of a rapid immunochromatographic test device.
THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
Inventor
Badwan, Adnan
Mohammed, Murshed, Abdel-Qader
Abstract
The present invention refers to a lateral-flow immunochromatographic test device comprising an optionally dye conjugated water-soluble chitosan and a dye conjugated water-soluble chitosan oligosaccharide. The present invention further refers to a use of said test device for observing a sample fluid flow. The present invention also refers to a use of an optionally dye conjugated water-soluble chitosan solution as a blocking solution, and to a dye conjugated chitosan oligosaccharide solution as a masking solution in the manufacture of said test device.
THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
TERRAMARK MARKENCREATION GMBH (Germany)
Inventor
Badwan, Adnan
Mohammed, Murshed, Abdel-Qader
Abstract
The present invention relates to a rapid immunochromatographic test device suitable to detect an antibody and/or antigen in a sample, uses of said device for detecting diseases in a sample, a method for the production of said device as well as a kit comprising the device.
THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
TERRAMARK MARKENCREATION GMBH (Germany)
Inventor
Badwan, Adnan
Mohammed, Murshed, Abdel-Qader
Abstract
The present invention relates to a method for rapid immunochromatographic detection of a target in a sample by double sandwich immunoassay detection, wherein the target is an antibody and/or an antigen, using different colloidal gold conjugates conjugated with a first and a second specific antibody or antigen and with at least one oligonucleotide and its at least one complementary oligonucleotide and/or at least one non-specific antibody and its related non-specific antigen, to a rapid immunochromatographic detection device, to uses of the method for detecting diseases or specific conditions, and to a method for the manufacture of the device as well as to a kit which comprises the device.
THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
TERRAMARK MARKENCREATION GMBH (Germany)
Inventor
Badwan, Adnan
Mohammed, Murshed, Abdel-Qader
Abstract
The present invention relates to a method for rapid immunochromatographic detection of a target in a sample, wherein the target is an antibody and/or an antigen, using different colloidal gold conjugates conjugated with a specific antibody and some oligonucleotides and their complementary oligonucleotides and/or antibodies and their related antigens, rapid immunochromatographic detection devices, uses of the method for detecting diseases or specific conditions, and a method for the manufacture of the devices as well as a kit which comprises the devices.
THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
TERRAMARK MARKENCREATION GMBH (Germany)
Inventor
Badwan, Adnan
Mohammed, Murshed, Abdel-Qader
Abstract
The present invention relates to a rapid immunochromatographic test device suitable to detect an antibody and/or antigen in a sample, uses of said device for detecting diseases in a sample, a method for the production of said device as well as a kit comprising the device.
THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
TERRAMARK MARKENCREATION GMBH (Germany)
Inventor
Badwan, Adnan
Mohammed, Murshed, Abdel-Qader
Abstract
The present invention refers to an immuno-chromatographic detection cup and its use for simultaneously detecting at least one antigen, e.g. tuberculosis antigen, malaria antigen and pneumonia antigen, and at least one antibody, e.g. HIV antibody, HCV antibody and H. pylori antibody, in a urine sample. The urinary detection cup comprises (a) a sample-collecting container; (b) a conjugate releasing pad comprising a gold labelled antibody X and an oligonucleotide linked antibody X', wherein both antibodies are directed against the same antigen, and a gold labelled antigen Y and an oligo-nucleotide linked antigen Y', wherein both antigens are recognized by the same antibody; (c) a test means inside the container separated from the conjugate releasing pad, which test means comprises a region comprising an oligo- nucleotide complementary to the oligo-nucleotide linked to antibody X', a region comprising an oligo-nucleotide complementary to the oligo-nucleotide linked antigen Y', and at least one region comprising a control antibody and/or a control antigen; and (d) at least two sample absorbent pads linked to the test device at different positions.
THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
TERRAMARK MARKENCREATION GMBH (Germany)
Inventor
Badwan, Adnan
Mohammed, Murshed, Abdel-Qader
Abstract
The present invention refers to a rapid immunochromatographic test device for antigen detection, comprising a first and a second conjugate releasing pad, wherein the first conjugate pad comprises a gold conjugated protein linked first oligonucleotide and a gold conjugated antigen specific antibody, and the second conjugate pad comprises a gold conjugated protein linked second oligonucleotide, which second oligonucleotide is complementary to the first oligonucleotide. The present invention further refers to a use of such test device for antigen detection in urine or saliva, e.g. human choriogonadotropin (hCG) in urine. Embodiments of the test device are a test strip and a detection cup. The present invention also refers to a method for manufacturing such test device.
THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
TERRAMARK MARKENCREATION GMBH (Germany)
Inventor
Badwan, Adnan
Mohammed, Murshed, Abdel-Qader
Abstract
The present invention relates to a method for rapid immunochromatographic detection of a target in a sample by double sandwich immunoassay detection, wherein the target is an antibody and/or an antigen, using different colloidal gold conjugates conjugated with a first and a second specific antibody or antigen, respectively, to a rapid immunochromatographic detection device, to uses of the method for detecting diseases or specific conditions, and to a method for the manufacture of the device as well as to a kit which comprises the device.
THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
TERRAMARK MARKENCREATION GMBH (Germany)
Inventor
Badwan, Adnan
Mohammed, Murshed, Abdel-Qader
Abstract
The present invention relates to a rapid immunochromatographic test device suitable to detect an antibody and/or antigen in at least one sample, uses of said device for detecting diseases in a sample, a method for the production of said device as well as a kit comprising the device.
THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
TERRAMARK MARKENCREATION GMBH (Germany)
Inventor
Badwan, Adnan
Mohammed, Murshed, Abdel-Qader
Abstract
The present invention refers to a rapid immunochromatographic test device for antibody detection, comprising at least a first and a second conjugate releasing pad, wherein the first conjugate pad comprises a gold conjugated protein linked first oligonucleotide and a gold conjugated anti-antibody, and the second conjugate pad comprises a gold conjugated protein linked second oligonucleotide, which second oligonucleotide is complementary to the first oligonucleotide. The present invention further refers to a use of such test device for antibody detection in urine or saliva, e.g. HIV antibody. Embodiments of the test device are a test strip and a detection cup. The present invention also refers to a method for manufacturing such test device.
THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
TERRAMARK MARKENCREATION GMBH (Germany)
Inventor
Badwan, Adnan
Mohammed, Murshed, Abdel-Qader
Abstract
The present invention relates to a rapid immune chromatographic test device suitable to detect more than one target in a single assay at the same time, uses of said device for detecting diseases in a sample, a method for the production of said device as well as a kit comprising the device.
THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
TERRAMARK MARKENCREATION GMBH (Germany)
Inventor
Badwan, Adnan
Al-Remawi, Mayyas
Rashid, Iyad, Said
Abstract
The invention is related to a co-precipitate comprising at least one hydrophilic polymeric compound selected from the group consisting of hydrophilic starch or its derivatives, and at least one water-absorbable compound selected from the group consisting of silicon dioxide, derivatives thereof, or any mixtures thereof, a method of preparing the same and use thereof.
THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
TERRAMARK MARKENCREATION GMBH (Germany)
Inventor
Badwan, Adnan
Al-Remawi, Mayyas
Fakherddin, Fadi, Mohammed, Tawfeeq
Al-Taani, Bashar, Mohammed
Abstract
The present invention relates to a microemulsified drug formulation comprising at least one surfactant, at least one co-surfactant, an oil phase, water and at least one drug selected from classes II-IV of the biopharmaceutical classification system (BCS).
THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
Inventor
Badwan, Adnan
Mohammed, Murshed Abdel-Qader
Abstract
The present invention refers to an immunochromatographic detection cup and its use for detecting human HIV-I, HIV-2, HCV and H. pylori antibodies in oral fluid.
B01L 3/00 - Containers or dishes for laboratory use, e.g. laboratory glasswareDroppers
A61B 10/00 - Instruments for taking body samples for diagnostic purposesOther methods or instruments for diagnosis, e.g. for vaccination diagnosis, sex determination or ovulation-period determinationThroat striking implements
24.
URINARY IMMUNOCHROMATOGRAPHIC ANTIGEN DETECTION CUP
THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
Inventor
Badwan, Adnan
Mohammed, Murshed, Abdel-Qader
Abstract
The present invention refers to an immunochromatographic detection cup and its use for detecting antigens in urine indicative of tuberculosis, Leishmania infection, malaria, Schistosoma infection and pneumonia.
THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
Inventor
Badwan, Adnan
Mohammed, Murshed Abdel-Qader
Abstract
The present invention refers to an indication means comprising an indicator, preferably a humidity colour indicator, and chitosan. The invention further refers to a lateral-flow test device comprising said indication means, and to a use of said test device for diagnosis, prognosis and/or observation of a disease. The invention also refers to a use of chitosan for the preparation of an indication means and/or a lateral-flow test device.
THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
AL-JBOUR, Nawzat, Dieb, Abedalghani (Jordan)
Inventor
Badwan, Adnan
Al-Remawi, Mayyas
Abstract
The present invention relates to a process for collecting and separating of water-insoluble pollutant from aqueous or soil environments, comprising the steps of: (i) applying an adsorbent composition comprising chitin, chitosan or derivatives thereof and at least one anionic surfactant to the aqueous or soil environment polluted with water-insoluble pollutant, so that the polymer having pollutant entrapped therein is coagulated, and (ii) separating the coagulated polymer from the aqueous or soil environment; and an absorbent composition utilized in that process.
THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
Inventor
Badwan, Adnan
Al-Remawi, Mayyas
Rashid, Iyad, Said
Abstract
The invention is related to a co-precipitate comprising at least one hydrophilic polymeric compound selected from the group consisting of chitin, chitin derivatives, other polyglucosamines, or any salts, solvates or mixtures thereof, and at least one water-absorbant compound selected from the group consisting of silicon dioxide, derivatives thereof, or any mixtures thereof, a method of preparing the same and novel uses thereof, novel co-precipitate, method for preparing the same and novel uses thereof.
THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
Inventor
Badwan, Adnan
Mohammed, Murshed Abdel-Qader Murshed
El-Taher, Tala Saleh Hamdan
Abstract
This invention provides a device for the simple and rapid detection of HIV in a sample that allows the detection of early human HIV infection. The device comprises a rapid immunochromatographic test for ultra sensitive p24 antigen detection. The device furthermore enables to distinguish between HIV-1 and HIV-2 infection. The invention further provides uses of the device in a method as well as a kit for the rapid detection of HIV in a sample.
THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
Inventor
Badwan, Adnan Ali
Al-Remawi, Mayyas
El-Taher, Talal
Elsayed, Amani
Abstract
A novel method of encapsulating a drug, preferably a peptide and/or protein drug in a biodegradable complex, which comprises: a) a biodegradable polymer that contains primary amine groups such as chitosan oligosaccharide, b) an organic carboxylic acid such as oleic acid, and c) optionally, an emulsifying agent such as plurol (glycerol-6-dioleate). The formula results in the formation of a continuous oily phase containing nanoparticles having the drug encapsulated therein.
A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
Inventor
Murshed, Abdelquader, Mohammed
Badwan, Adnan
Abstract
The present invention refers to a lateral-flow test device comprising means for releasing a test buffer harboured by the test device such that a sample to be tested, preferably body fluid, is exposed to the test buffer. The invention also refers to a whole blood lateral-flow test device additionally comprising a lancet (13) and means for ejecting the lancet (14). Preferably, the analyte in the sample to be tested, e.g. whole blood, is an antibody or antigen. Furthermore, the invention refers to uses of said test devices.
THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
Inventor
Badwan, Adnan
Al-Remawi, Mayyas
Abstract
Chitosan silicone dioxide coprecipitate composition, method of production thereof, pharmaceutical composition comprising the chitosan silicone dioxide coprecipitate composition and use of the chitosan silicone dioxide coprecipitate composition for manufacturing a sustained or immediate release formulation.
THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
TERRAMARK MARKENCREATION GMBH (Germany)
Inventor
Badwan, Adnan
Al-Remawi, Mayyas
Abstract
The invention relates to a molecular ionic complex formed between an acidic pharmaceutical drug or its salt or solvate and glucosamine, chondroitin, hyaluronic acid or heparin or its salts or derivatives. The complex can provide for a liquid oral controlled drug delivery. For example, ibuprofen sodium complex with glucosamine sulfate potassium (GSP) was found to have a zero order controlled drug delivery when given orally to rabbits.
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
A61K 31/196 - Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
A61K 31/195 - Carboxylic acids, e.g. valproic acid having an amino group
A61K 31/545 - Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula , e.g. cephalosporins, cefaclor, cephalexine
A61K 31/546 - Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula , e.g. cephalosporins, cefaclor, cephalexine containing further heterocyclic rings, e.g. cephalothin
33.
COMPOSITION CONTAINING CHITOSAN FOR SUSTAINED DRUG RELEASE
THE JORDANIAN PHARMACEUTICAL MANUFACTURING CO. (Jordan)
Inventor
Badwan, Adnan
Al-Remawi, Mayyas, Mohammed, Ahmad
Mohammed, Murshed, Abdel-Qader
Abstract
The present invention relates to a composition for sustained drug release, comprising chitosan dissolved in a solvent having a pH of below about 4.0, wherein the chitosan is selected from the group of chitosans precipitating in a pH range of between about 3.0 and about 7.5; and at least one drug compound soluble in the above chitosan solution.