Abstract

Disclosed herein are a microorganism with excellent deacetoxycephalosporin C (DAOC) productivity and a use thereof. A mutant microorganism with improved DAOC productivity and a use thereof for producing 7-aminodeacetoxycephalosporanic acid (7-ADCA) are provided.

IPC Classes  ?

• C12P 13/02 - Amides, e.g. chloramphenicol
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12N 9/90 - Isomerases (5.)
• C12N 15/80 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi
• C12P 17/18 - Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin

Abstract

Provided are immunoglobulin-binding protein variants with increased alkali tolerance, and uses thereof, and more particularly to immunoglobulin-binding protein variants with increased alkali tolerance relative to the wild type due to mutations in amino acids at specific positions in the B3 domain of the immunoglobulin-binding proteins

IPC Classes  ?

• B01J 20/32 - Impregnating or coating
• C07K 1/22 - Affinity chromatography or related techniques based upon selective absorption processes

Abstract

Disclosed herein are a polypeptide having cephalosporin C(CPC) acylase activity and a use thereof. More specifically, a mutant CPC acylase comprising a point mutation introduced thereinto, thereby exhibiting improved enzymatic activity and/or stability, and a use of the mutant CPC acylase for producing 7-aminocephalosporanic acid (7-ACA), are provided.

IPC Classes  ?

• C12N 9/80 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides
• C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression

Goods & Services

Mixed vitamin preparations; pharmaceutical products for treating respiratory diseases and asthma; medical preparations for slimming purposes; medicines for human purposes; dietetic substances adapted for medical use; ferments for medical or veterinary use; nutritional supplements for medical use; adjuvants for medical purposes; antibiotic preparations; calcium supplements; food for babies (except lacteal flour for babies); medicines for the treatment of gastrointestinal diseases; chemico-pharmaceutical preparations; ferments for pharmaceutical purposes; allergy medications; ophthalmic preparations; nervines; cardiovascular pharmaceutical preparations; biological preparations for veterinary purposes; pharmaceutical agents affecting digestive organs; anti-inflammatory and antipyretic preparations; bouillons for bacteriological cultures; biological preparations; sterilising preparations; pharmaceutical products for the treatment of bone diseases; vitamin preparations; vaccines; pharmaceutical preparations for immunity adjustment; mineral food supplements; lactose for pharmaceutical purposes; pharmaceutical preparations for animals; pharmaceutical agents affecting metabolism; pharmaceutical preparations for treating diabetes; androgen preparations; pharmaceutical agents affecting sensory organs; nutritional supplements mainly based on lactic acid bacteria; nutritional supplements mainly based on aloe extracts; nutritional supplements mainly based on coenzyme Q10; nutritional supplements mainly based on grape seed extract; nutritional supplements mainly based on medicinal herbs; nutritional supplements mainly based on vitamin B complex (vitamin B1, B2, B12); nutritional supplements mainly based on fish oil for food; nutritional supplements mainly based on fucoidan; nutritional supplements mainly based on calcium derived from aquatic products; nutritional supplements mainly based on fructo-oligosaccharide from inulin derived from chicory roots; nutritional supplements mainly based on reishi mushroom extracts; nutritional supplements mainly based on folic acid; nutritional supplements mainly based on chitosan oligosaccharide derived from shell of crustaceans; nutritional supplements mainly based on garcinia cambogia; nutritional supplements mainly based on garlic; dietary drink mixes for loosing weight. Food products made from lactic acid bacteria; food products made from beans (excluding bean curds and foodstuffs made from bean curds); food products made primarily from fruits; yoghurt; milk; processed dairy products; lactic acid bacteria drinks; milk products; powdered milk (except for infants); processed meat products; processed vegetable products; cheese; processed seaweed products; protein milk; edible fats. Processed cereals; leaven; frozen yoghurt [confectionery ices]; fructo-oligosaccharide for culinary purposes; muesli; cereal-based processed products; oat-based food; farinaceous food pastes for human consumption; oatmeal; Korean rice-wine starter (Nuruk); baking powder; ferments for dough; wheat germ for human consumption; vinegar; ketchup [sauce]; processed coffee; cereal preparations; beverages with a tea base; glucose for food. Energy drinks containing carbohydrates/vitamins derived from fruits; fruit juices; powders for effervescing beverages; pastilles for effervescing beverages; non-alcoholic fruit extracts; non-alcoholic beverages; energy drinks containing vitamin C; soda pops; energy drinks containing medicinal herbs; energy drinks containing proteins/amino acids/calcium derived from milk; whey beverages; powders used in the preparation of fruit-based beverages; preparations for making non-alcoholic drinks; vegetable-based beverages and fruit-based beverages; energy drinks containing coenzyme Q10; carbonated water; energy drinks containing soybean milk.

Goods & Services

Mixed vitamin preparations; medical preparations for slimming purposes; medicines for human purposes; ferments for medical or veterinary use; adjuvants for medical purposes; antibiotic preparations; calcium supplements; food for babies (except lacteal flour for babies); chemico-pharmaceutical preparations; allergy medications; cardiovascular pharmaceutical preparations; pharmaceutical agents affecting digestive organs; anti-inflammatory and antipyretic preparations; bouillons for bacteriological cultures; biological preparations; pharmaceutical preparations for immunity adjustment; mineral food supplements; lactose for pharmaceutical purposes; pharmaceutical preparations for animals; pharmaceutical agents affecting sensory organs; nutraceuticals for medical or therapeutic purposes; vitamin supplements; nutraceuticals mainly based on red ginseng; capsules for medicines; nutraceuticals mainly based on glucosamine derived from shell of crustaceans (such as crabs or shrimps); nutraceuticals mainly based on N-acetylglucosamine derived from shell of crustaceans (such as crabs or shrimps, etc.); nutraceuticals mainly based on N-acetylglucosamine derived from bone of molluscs (such as squid, etc.); nutraceuticals mainly based on chitosans/chitosan oligosaccharide derived from crustaceans shell/molluscs bone; nutraceuticals mainly based on lutein derived from marigold; nutraceuticals mainly based on lactic acid bacteria; nutraceuticals mainly based on pinitol derived from carob (legumes); nutraceuticals mainly based on collagen peptide derived from pig's skin; nutraceuticals mainly based on collagen peptide derived from fish scales; nutraceuticals mainly based on fucoxanthin derived from brown algae (such as seaweed or gulf weed, etc.); nutraceuticals mainly based on coenzyme Q10 derived from vegetables; nutraceuticals mainly based on probiotics derived from milk products; dietetic beverages adapted for medical purposes containing N-acetylglucosamine (yoghurt); protein dietary supplements; dietary and nutritional supplements; dietary supplement drinks; nutritional supplements mainly based on red ginseng; nutritional supplements mainly based on ginseng; nutritional supplements mainly based on glucosamine derived from shell of crustaceans (such as crabs or shrimps); nutritional supplements mainly based on N-acetylglucosamine derived from shell of crustaceans (such as crabs or shrimps, etc.); nutritional supplements mainly based on N-acetylglucosamine derived from bone of molluscs (such as squid, etc.); nutritional supplements mainly based on chitosans/chitosan oligosaccharide derived from crustaceans shell/molluscs bone; nutritional supplements mainly based on lutein derived from marigold; nutritional supplements mainly based on lactic acid bacteria; nutritional supplements mainly based on pinitol derived from carob (legumes); nutritional supplements mainly based on collagen peptide derived from pig's skin; nutritional supplements mainly based on collagen peptide derived from fish scales; nutritional supplements mainly based on fucoxanthin derived from brown algae (such as seaweed or gulf weed, etc.); nutritional supplements mainly based on ginko biloba; nutritional supplements mainly based on dietary fiber derived from psyllium husk; nutritional supplements mainly based on coenzyme Q10 derived from vegetables; nutritional supplements mainly based on isoflavone derived from soya beans; nutritional supplements mainly based on polydextrose derived from chicory roots; nutritional supplements mainly based on probiotics derived from milk products; nutritional supplements mainly based on grain enzymes; nutritional supplements mainly based on edible saccharides; nutritional supplements mainly based on leaven; nutritional supplements mainly based on fructo-oligosaccharide for culinary purposes; nutritional supplements mainly based on brown rice; nutritional supplements mainly based on fermented grain powder; nutritional supplements against hangover mainly based on grain; nutritional supplements against hangover mainly based on enzymes derived from grain; nutritional supplements mainly based on enzymes derived from grain; dietary drink mixes for loosing weight. Lactic acid bacteria drinks; food products made from beans (excluding bean curds and foodstuffs made from bean curds); food products made primarily from fruits; yoghurt; milk; processed dairy products; nut-based snack foods; preserved, frozen, dried and cooked fruits and vegetables; jellies for food; food products made from fish and shellfish; dried edible mushrooms; milkthistle being processed food; milk products; powdered milk (except for infants); processed meat products; processed vegetable products; cheese; processed seaweed products; protein milk; edible fats; milk products containing N-acetylglucosamine; processed dairy products and lactic acid bacteria drinks containing N-acetylglucosamine. Cereal-based processed products; cereal preparations; processed cereals; mixed grains powder based on grain-fermented enzymes; bay salt for food; bamboo-salt; processed foods mainly based on grain-fermented enzymes; processed foods mainly based on grain; processed grain foods against hangover; processed foods against hangover mainly based on enzymes derived from grain; processed foods mainly based on enzymes derived from grain. Non-alcoholic beverages; soft drinks; sparkling juice based beverages; mushroom drinks; barley-based beverages; vitamin enriched water [beverages]; soda water; energy drinks against hangover, not for medical purposes; sports drinks; energy drinks; carbonated water; tonic water; powders for effervescing beverages; pastilles for effervescing beverages; syrups for beverages; waters [beverages]; concentrates, syrups and powders used in the preparation of soft drinks; whey beverages; non-alcoholic beverages flavoured with tea; coconut-based beverages; N-acetylglucosamine powder for beverages; collagen peptide powder for beverages; pinitol powder for beverages; fucoxanthin powder for beverages; energy drinks containing N-acetylglucosamine derived from shell of crustaceans (such as crabs or shrimps, etc.); energy drinks containing N-acetylglucosamine derived from bone of molluscs (such as squid, etc.); energy drinks containing collagen peptide derived from pig's skin; energy drinks containing collagen peptide derived from fish scales; energy drinks containing pinitol derived from carob (legumes); energy drinks containing fucoxanthin derived from brown algae (such as seaweed or gulf weed, etc.); non-alcoholic drinks enriched with N-acetylglucosamine; non-alcoholic drinks enriched with collagen peptide; non-alcoholic drinks enriched with pinitol; non-alcoholic drinks enriched with fucoxanthin; red ginseng drinks containing N-acetylglucosamine; red ginseng drinks containing collagen peptide; red ginseng drinks containing pinitol; red ginseng drinks containing fucoxanthin; vegetable-based beverages and fruit-based beverages.

Goods & Services

Peptides for making processed foods; peptides (raw materials) for use in the manufacture of food; peptides (other than for medical purposes); collagen peptides for cosmetics; peptides (raw materials) for use in the manufacture of food for animals; collagen used as a raw ingredient in the manufacture of cosmetics; proteins for use in the manufacture of food supplements; proteins for use in the manufacture of food and beverages; chemical additives for use in the manufacture of food; lactose for the food industry; proteins for the food industry; amino acid for food industry; enzymes for the beverage industry; enzymes for use in the manufacture of nutraceuticals; enzyme substrates; enzymes for use in the processing of food by-products; collagen for industrial purposes; active chemical ingredients for use in the manufacture of anti-cancer drugs; active chemical ingredients; probiotic bacteria for the food industry. Collagen preparations for cosmetic purposes; herbal extracts for cosmetic purposes; body and beauty care cosmetics; nail cosmetics; cosmetics; cosmetic preparations for slimming purposes; cosmetic preparations for the hair and scalp; natural essential oils; food flavourings [essential oils]; anti-aging cosmetic preparations; sunscreen preparations; creams for cellulite reduction for cosmetic use; seaweed for cosmetology; perfumes; extracts of flowers [perfumes]; natural perfumery made from plants; perfumery; tissues impregnated with cosmetics; shampoos; soaps for personal use. Dietary supplements for infants; pharmaceutical preparations for health care; medicinal healthcare preparations; dietetic beverages adapted for medical purposes; dietary supplements; nutraceuticals for use as a dietary supplement; dietary supplements consisting of amino acids, minerals and trace elements; dietary supplements for controlling cholesterol; enzyme dietary supplements; anti-oxidant food supplements; digestive enzymes; enzymes for veterinary purposes; enzymes for medical purposes; nutraceutical preparations for therapeutic or medical purposes; synthetic peptides for pharmaceutical purposes; meal replacement powders; collagen for medical purposes; probiotic preparations for medical use; dietary supplement drink mixes; dietary supplements for pets. Meal; processed cereals; high-protein cereal bars; cereal-based snack food; processed cereals for food for human consumption; gluten prepared as foodstuff; yeast; ferments for dough; frozen yoghurt [confectionery ices]; natural sweeteners; royal jelly; molasses for food; propolis; aromatic preparations for food; garden herbs, preserved [seasonings]; spices in the form of powders; flavourings, other than essential oils, for beverages; protein-enriched coffee; cookies; flavored jelly crystals for making jelly confectionery.

Goods & Services

Peptides for making processed foods; peptides (raw materials) for use in the manufacture of food; peptides (other than for medical purposes); collagen peptides for cosmetics; peptides (raw materials) for use in the manufacture of food for animals; collagen used as a raw ingredient in the manufacture of cosmetics; proteins for use in the manufacture of food supplements; proteins for use in the manufacture of food and beverages; chemical additives for use in the manufacture of food; lactose for the food industry; proteins for the food industry; amino acid for food industry; enzymes for the beverage industry; enzymes for use in the manufacture of nutraceuticals; enzyme substrates; enzymes for use in the processing of food by-products; collagen for industrial purposes; active chemical ingredients for use in the manufacture of anti-cancer drugs; active chemical ingredients; probiotic bacteria for the food industry; lactic acid bacteria powder. Collagen preparations for cosmetic purposes; herbal extracts for cosmetic purposes; body and beauty care cosmetics; nail cosmetics; cosmetics; cosmetic preparations for slimming purposes; cosmetic preparations for the hair and scalp; natural essential oils; food flavourings [essential oils]; anti-aging cosmetic preparations; sunscreen preparations; creams for cellulite reduction for cosmetic use; seaweed for cosmetology; perfumes; extracts of flowers [perfumes]; natural perfumery made from plants; perfumery; tissues impregnated with cosmetics; shampoos; soaps for personal use. Dietary supplements for infants; pharmaceutical preparations for health care; medicinal healthcare preparations; dietetic beverages adapted for medical purposes; dietary supplements; nutraceuticals for use as a dietary supplement; dietary supplements consisting of amino acids, minerals and trace elements; enzyme dietary supplements; anti-oxidant food supplements; digestive enzymes; enzymes for veterinary purposes; enzymes for medical purposes; nutraceutical preparations for therapeutic or medical purposes; synthetic peptides for pharmaceutical purposes; meal replacement powders; collagen for medical purposes; probiotic preparations for medical use; dietary supplement drink mixes; dietary supplements for pets; nutraceuticals mainly based on bifidus bacteria; nutritional supplements mainly based on lactic acid bacteria. Preserved, frozen, dried and cooked fruits and vegetables; milk substitutes; vegetable-based snack foods; nut-based snack foods; fruit-based snack food; dried edible mushrooms; milkthistle being processed food; soup concentrates; jellies for food; yogurt; beans, preserved; milk; milk products; lactic acid drinks; cheese; seaweed extracts for food; food products made from fish and shellfish; lactic acid bacteria beverages with collagen.

Goods & Services

Peptides for making processed foods; peptides (raw materials) for use in the manufacture of food; peptides (other than for medical purposes); collagen peptides for cosmetics; peptides (raw materials) for use in the manufacture of food for animals; collagen used as a raw ingredient in the manufacture of cosmetics; proteins for use in the manufacture of food supplements; proteins for use in the manufacture of food and beverages; chemical additives for use in the manufacture of food; lactose for the food industry; proteins for the food industry; amino acid for food industry; enzymes for the beverage industry; enzymes for use in the manufacture of nutraceuticals; enzyme substrates; enzymes for use in the processing of food by-products; collagen for industrial purposes; active chemical ingredients for use in the manufacture of anti-cancer drugs; active chemical ingredients; probiotic bacteria for the food industry; lactic acid bacteria powder. Collagen preparations for cosmetic purposes; herbal extracts for cosmetic purposes; body and beauty care cosmetics; nail cosmetics; cosmetics; cosmetic preparations for slimming purposes; cosmetic preparations for the hair and scalp; natural essential oils; food flavourings [essential oils]; anti-aging cosmetic preparations; sunscreen preparations; creams for cellulite reduction for cosmetic use; seaweed for cosmetology; perfumes; extracts of flowers [perfumes]; natural perfumery made from plants; perfumery; tissues impregnated with cosmetics; shampoos; soaps for personal use. Dietary supplements for infants; pharmaceutical preparations for health care; medicinal healthcare preparations; dietetic beverages adapted for medical purposes; dietary supplements; nutraceuticals for use as a dietary supplement; dietary supplements consisting of amino acids, minerals and trace elements; enzyme dietary supplements; anti-oxidant food supplements; digestive enzymes; enzymes for veterinary purposes; enzymes for medical purposes; nutraceutical preparations for therapeutic or medical purposes; synthetic peptides for pharmaceutical purposes; meal replacement powders; collagen for medical purposes; probiotic preparations for medical use; dietary supplement drink mixes; dietary supplements for pets; nutraceuticals mainly based on bifidus bacteria; nutritional supplements mainly based on lactic acid bacteria. Preserved, frozen, dried and cooked fruits and vegetables; milk substitutes; vegetable-based snack foods; nut-based snack foods; fruit-based snack food; dried edible mushrooms; milk thistle being processed food; soup concentrates; jellies for food; yogurt; beans, preserved; milk; milk products; lactic acid drinks; cheese; seaweed extracts for food; food products made from fish and shellfish; lactic acid bacteria beverages with collagen.

Goods & Services

Peptides for making processed foods; peptides (raw materials) for use in the manufacture of food; peptides (other than for medical purposes); collagen peptides for cosmetics; peptides (raw materials) for use in the manufacture of food for animals; collagen used as a raw ingredient in the manufacture of cosmetics; proteins for use in the manufacture of food supplements; proteins for use in the manufacture of food and beverages; chemical additives for use in the manufacture of food; lactose for the food industry; proteins for the food industry; amino acid for food industry; enzymes for the beverage industry; enzymes for use in the manufacture of nutraceuticals; enzyme substrates; enzymes for use in the processing of food by-products; collagen for industrial purposes; active chemical ingredients for use in the manufacture of anti-cancer drugs; active chemical ingredients; probiotic bacteria for the food industry; lactic acid bacteria powder. Collagen preparations for cosmetic purposes; herbal extracts for cosmetic purposes; body and beauty care cosmetics; nail cosmetics; cosmetics; cosmetic preparations for slimming purposes; cosmetic preparations for the hair and scalp; natural essential oils; food flavourings [essential oils]; anti-aging cosmetic preparations; sunscreen preparations; creams for cellulite reduction for cosmetic use; seaweed for cosmetology; perfumes; extracts of flowers [perfumes]; natural perfumery made from plants; perfumery; tissues impregnated with cosmetics; shampoos; soaps for personal use. Dietary supplements for infants; pharmaceutical preparations for health care; medicinal healthcare preparations; dietetic beverages adapted for medical purposes; dietary supplements; nutraceuticals for use as a dietary supplement; dietary supplements consisting of amino acids, minerals and trace elements; enzyme dietary supplements; anti-oxidant food supplements; digestive enzymes; enzymes for veterinary purposes; enzymes for medical purposes; nutraceutical preparations for therapeutic or medical purposes; synthetic peptides for pharmaceutical purposes; meal replacement powders; collagen for medical purposes; probiotic preparations for medical use; dietary supplement drink mixes; dietary supplements for pets; nutraceuticals mainly based on bifidus bacteria; nutritional supplements mainly based on lactic acid bacteria. Preserved, frozen, dried and cooked fruits and vegetables; milk substitutes; vegetable-based snack foods; nut-based snack foods; fruit-based snack food; dried edible mushrooms; milk thistle being processed food; soup concentrates; jellies for food; yogurt; beans, preserved; milk; milk products; lactic acid drinks; cheese; seaweed extracts for food; food products made from fish and shellfish; lactic acid bacteria beverages with collagen.

Goods & Services

Peptides for making processed foods; peptides (raw materials) for use in the manufacture of food; peptides (other than for medical purposes); collagen peptides for cosmetics; peptides (raw materials) for use in the manufacture of food for animals; collagen used as a raw ingredient in the manufacture of cosmetics; proteins for use in the manufacture of food supplements; proteins for use in the manufacture of food and beverages; chemical additives for use in the manufacture of food; lactose for the food industry; proteins for the food industry; amino acid for food industry; enzymes for the beverage industry; enzymes for use in the manufacture of nutraceuticals; enzyme substrates; enzymes for use in the processing of food by-products; collagen for industrial purposes; active chemical ingredients for use in the manufacture of anti-cancer drugs; active chemical ingredients; probiotic bacteria for the food industry; lactic acid bacteria powder. Collagen preparations for cosmetic purposes; herbal extracts for cosmetic purposes; body and beauty care cosmetics; nail cosmetics; cosmetics; cosmetic preparations for slimming purposes; cosmetic preparations for the hair and scalp; natural essential oils; food flavourings [essential oils]; anti-aging cosmetic preparations; sunscreen preparations; creams for cellulite reduction for cosmetic use; seaweed for cosmetology; perfumes; extracts of flowers [perfumes]; natural perfumery made from plants; perfumery; tissues impregnated with cosmetics; shampoos; soaps for personal use. Dietary supplements for infants; pharmaceutical preparations for health care; medicinal healthcare preparations; dietetic beverages adapted for medical purposes; dietary supplements; nutraceuticals for use as a dietary supplement; dietary supplements consisting of amino acids, minerals and trace elements; enzyme dietary supplements; anti-oxidant food supplements; digestive enzymes; enzymes for veterinary purposes; enzymes for medical purposes; nutraceutical preparations for therapeutic or medical purposes; synthetic peptides for pharmaceutical purposes; meal replacement powders; collagen for medical purposes; probiotic preparations for medical use; dietary supplement drink mixes; dietary supplements for pets; nutraceuticals mainly based on bifidus bacteria; nutritional supplements mainly based on lactic acid bacteria. Preserved, frozen, dried and cooked fruits and vegetables; milk substitutes; vegetable-based snack foods; nut-based snack foods; fruit-based snack food; dried edible mushrooms; milk thistle being processed food; soup concentrates; jellies for food; yogurt; beans, preserved; milk; milk products; lactic acid drinks; cheese; seaweed extracts for food; food products made from fish and shellfish; lactic acid bacteria beverages with collagen.

Goods & Services

Peptides for making processed foods; peptides (raw materials) for use in the manufacture of food; peptides (other than for medical purposes); collagen peptides for cosmetics; peptides (raw materials) for use in the manufacture of food for animals; collagen used as a raw ingredient in the manufacture of cosmetics; proteins for use in the manufacture of food supplements; proteins for use in the manufacture of food and beverages; chemical additives for use in the manufacture of food; lactose for the food industry; proteins for the food industry; amino acid for food industry; enzymes for the beverage industry; enzymes for use in the manufacture of nutraceuticals; enzyme substrates; enzymes for use in the processing of food by-products; collagen for industrial purposes; active chemical ingredients for use in the manufacture of anti-cancer drugs; active chemical ingredients; probiotic bacteria for the food industry. Collagen preparations for cosmetic purposes; herbal extracts for cosmetic purposes; body and beauty care cosmetics; nail cosmetics; cosmetics; cosmetic preparations for slimming purposes; cosmetic preparations for the hair and scalp; natural essential oils; food flavourings [essential oils]; anti-aging cosmetic preparations; sunscreen preparations; creams for cellulite reduction for cosmetic use; seaweed for cosmetology; perfumes; extracts of flowers [perfumes]; natural perfumery made from plants; perfumery; tissues impregnated with cosmetics; shampoos; soaps for personal use. Dietary supplements for infants; pharmaceutical preparations for health care; medicinal healthcare preparations; dietetic beverages adapted for medical purposes; dietary supplements; nutraceuticals for use as a dietary supplement; dietary supplements consisting of amino acids, minerals and trace elements; dietary supplements for controlling cholesterol; enzyme dietary supplements; anti-oxidant food supplements; digestive enzymes; enzymes for veterinary purposes; enzymes for medical purposes; nutraceutical preparations for therapeutic or medical purposes; synthetic peptides for pharmaceutical purposes; meal replacement powders; collagen for medical purposes; probiotic preparations for medical use; dietary supplement drink mixes; dietary supplements for pets. Meal; processed cereals; high-protein cereal bars; cereal-based snack food; processed cereals for food for human consumption; gluten prepared as foodstuff; yeast; ferments for pastes; frozen yoghurt [confectionery ices]; natural sweeteners; royal jelly; molasses for food; propolis; aromatic preparations for food; garden herbs, preserved [seasonings]; spices in the form of powders; flavourings, other than essential oils, for beverages; protein-enriched coffee; cookies; flavored jelly crystals for making jelly confectionery.

Goods & Services

Capsules for medicines, namely, pharmaceutical agents affecting digestive organs; health functional food containing glucosamine extracted from shellfish such as crab or shrimp, namely, food for enteral feeding; health functional food containing N-acetylglucosamine extracted from shellfish such as crab or shrimp, namely, food for enteral feeding; health functional food containing N-acetylglucosamine extracted from the bones of mollusks such as squid as the main ingredient, namely, food for enteral feeding; health functional food made from chitosan or chitooligosaccharides extracted from crustacean shells or mollusk bonds, namely, food for enteral feeding; health functional food with collagen peptide extracted from pig skin as the main ingredient, namely, food for enteral feeding; health functional food using collagen peptides extracted from fish scales as the main ingredient, namely, food for enteral feeding

Abstract

The present invention relates to a novel Aspergillus niger AG1 strain and, more specifically, to: a method for preparing β-glycosidase, comprising a step of culturing the strain; a method for preparing compound K, comprising a step in which β-glycosidase derived from the strain comes into contact with a substrate; and a food composition, a cosmetic composition and a pharmaceutical composition, containing, as an active ingredient, compound K produced by means of the compound K preparation method.

IPC Classes  ?

• C12N 1/14 - Fungi Culture media therefor
• C12N 9/24 - Hydrolases (3.) acting on glycosyl compounds (3.2)
• C12P 33/20 - Preparation of steroids containing heterocyclic rings
• A23L 29/00 - Foods or foodstuffs containing additivesPreparation or treatment thereof
• A61K 8/63 - SteroidsDerivatives thereof
• A61Q 19/00 - Preparations for care of the skin
• A61K 31/56 - Compounds containing cyclopenta[a]hydrophenanthrene ring systemsDerivatives thereof, e.g. steroids
• A61P 17/10 - Anti-acne agents
• A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Goods & Services

Processed cereals; cereal-based processed products, namely, namely, cereal-bars; foods and health functional foods containing enzymes made by fermenting grains, namely, cereal based snack foods; food made from fermented grain enzymes, namely, processed grains; grain-based foods and health functional foods, namely, grain-based snack foods; cereal preparations, namely, cereal-bars; health functional food containing grain enzymes as the main ingredient, namely, grain-based snack foods

Goods & Services

Medicinal tonics, namely, mineral, vitamin, or nutritionally enhanced water for medical purposes; pharmaceutical preparations to regulate an immune system; mineral nutritional supplements; mineral supplements; nutritive substances for microorganisms for medical purposes; vitamin tablets; vitamin preparations; pharmaceutical products for the treatment of bone diseases; fungicides; insecticides; medium for bacterial culture, namely, bacteriological culture mediums; food for infants; ferments for medical or veterinary use; adjuvants for medical purposes; fodder additives in the nature of dietary supplements for medical purposes; medical nutritional supplements; calcium supplements; anti-diabetic pharmaceuticals; hypoglycemic agents; mixed vitamins; health functional food with ginseng as the main ingredient, namely, dietetic foods adapted for medical use; health food supplement made with lactic acid bacteria as the main ingredient; a health food supplement made with calcium from seaweed as the main ingredient; health food supplements containing EPA/DHA ingredients from edible fish; health food supplements with aloe extract as the main ingredient; a health food supplement containing chitosan extracted from crabs; Health dietary supplement drink mixes with protein, amino acids, and calcium extracted from milk; a health dietary supplement drink mix made with carbohydrates and vitamins extracted from fruits Health functional food with ginseng as the main ingredient, namely, vegetable-based snack food; health functional food with red ginseng as the main ingredient, namely, vegetable-based snack food; health functional food with refined fish oil as the main ingredient, namely, powdered oils and fats for food; health functional food containing garcinia cambogia extract as the main ingredient, namely, vegetable-based snack foods; health functional food containing glucosamine extracted from the shells of crustaceans, namely, fish-based snack food; a health functional food containing N-acetylglucosamine extracted from shellfish shells as the main ingredient, namely, fish-based snack food; health functional food containing chitosan extracted from the shells of crustaceans, namely, fish-based snack food; health functional food containing chitooligosaccharide extracted from the shells of crustaceans, namely, fish-based snack food; health functional food with collagen extracted from fish scales as the main ingredient, namely, fish-based snack food; health functional food with collagen peptide extracted from fish scales as the main ingredient, namely, fish-based snack food; health functional food with collagen extracted from pig skin as the main ingredient, namely, meat-based snack food; health functional food with collagen peptide extracted from pig skin as the main ingredient, namely, jellies, jams; health functional food with fucoxanthin extracted from seaweed as the main ingredient, namely, seaweed-based snacks; Health functional food containing lactic acid bacteria as the main ingredient, namely, lactic acid bacteria drinks; health functional food containing vitamin B group such as B1, B2, B12 as the main ingredient, namely, fungal extracts for use as ingredients of nutritional supplements and vitamins; Health functional food containing folic acid such as folinic acid as the main ingredient, namely, lactic acid drinks; processed ginseng for use as a vegetable; processed red ginseng for use as a vegetable; lactic acid bacteria drink Processed cereals; food leavening agents; fructo-oligosaccharide for culinary purposes in the nature of fructose for food; muesli; cereal-based processed products, namely, cereal bars; oat-based food, namely, processed oats; farinaceous food pastes for human consumption; oatmeal; Korean rice-wine starter in the nature of yeast, namely, Nuruk; baking powders; ferments for pastes, namely, dough ferments for culinary purposes; malt for food purposes; vinegar; ketchup; processed coffee; cereal preparations, namely, processed cereals; beverages with a tea base; glucose for food, namely, glucose for culinary purposes; Confectionery, namely, pastilles for effervescing beverages; Processed ginseng extract used as a flavoring for drinks Health functional beverage made from glucosamine extracted from shellfish shells in the nature of non-alcoholic water-based beverages; health functional beverage made with N-acetylglucosamine extracted from shellfish shells in the nature of non-alcoholic water-based beverages; a functional health drink containing chitooligosaccharide extracted from the shells of crustaceans as the main ingredient in the nature of non-alcoholic water-based beverages; a health functional beverage made with collagen extracted from fish scales as the main ingredient in the nature of non-alcoholic water-based beverages; a health functional beverage made from collagen peptides extracted from fish scales in the nature of non-alcoholic water-based beverages; a health functional beverage made with collagen extracted from pig skin as the main ingredient in the nature of non-alcoholic water-based beverages; a health functional beverage made with collagen peptides extracted from pig skin as the main ingredient in the nature of non-alcoholic water-based beverages; functional health drink with fucoxanthin extracted from seaweed as the main ingredient in the nature of non-alcoholic water-based beverages; health functional beverage containing vitamin C as the main ingredient in the nature of non-alcoholic water-based beverages; health functional beverage with coenzyme Q10 as the main ingredient in the nature of non-alcoholic water-based beverages; health functional beverage made with ginseng as the main ingredient in the nature of non-alcoholic beverages containing ginseng juice; Health functional beverage made with red ginseng as the main ingredient in the nature of non-alcoholic beverages containing red ginseng juice; health functional beverage made with soybean oil as the main ingredient in the nature of non-alcoholic water-based beverages; health functional beverage with evening primrose oil as the main ingredient in the nature of non-alcoholic water-based beverages; Health supplement drink with protein/amino acids/calcium extracted from milk in the nature of non-alcoholic water-based beverages; a health supplement drink made with carbohydrates/vitamins extracted from fruits in the nature of non-alcoholic water-based beverages; health functional beverage with garcinia cambogia extract as the main ingredient in the nature of non-alcoholic water-based beverages; functional food and drink for diet, namely, non-alcoholic vegetable juice beverages

Abstract

The present invention relates to a penicillin G acylase mutant having increased cefazoline productivity and a use thereof, wherein Achromobacter sp. CCM 4824-derived penicillin G acylase mutants having unique mutation forms disclosed in the present invention have a very high synthesis activity specifically for cefazoline, compared to wild-type enzyme thereof and other known mutant forms, and have a remarkably high synthesis ratio (S/H ratio) compared to the degradation activity of a substrate used for synthesis of cefazoline, and thus the productivity of cefazoline is remarkably increased to a significant level in industrial applications.

IPC Classes  ?

• C12N 9/84 - Penicillin amidase
• C12P 35/04 - Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position

Abstract

The present invention relates to a method for preparing a recombinant acremonium chrysogenum strain producing a high concentration of deacetoxycephalosporin C (DAOC), and a strain prepared by same method and, more specifically, to a method for preparing an acremonium chrysogenum strain producing DAOC with high yield, a recombinant acremonium chrysogenum strain prepared by same method, a DAOC production method for culturing the strain under conditions capable of producing DAOC and recovering the DAOC, a polynucleotide for high DAOC expression in the acremonium chrysogenum strain used in the production method, an expression vector for high DAOC expression in the acremonium chrysogenum strain, and a method for producing 7-ADCA by treating the produced DAOC with CPC acylase.

IPC Classes  ?

• C12N 9/10 - Transferases (2.)
• C12N 9/02 - Oxidoreductases (1.), e.g. luciferase
• C12P 35/00 - Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin

Abstract

The present invention relates to an antibody-purifying resin having an excellent impurity removal potential and, more particularly, to an antibody-purifying resin wherein a part of amino acid residues of protein A is substituted, whereby the resin can exhibit an excellent potential to remove impurities such as host cell-derived proteins (HCP), host cell-derived DNA (HCD), etc. Having an excellent potential of removing host cell-derived impurities, the resin according to the present invention allows the omission of subsequent processes for removing impurities in the antibody purification procedure therethrough or the reduction of a load of impurities to be treated in subsequent processes, whereby the resin can be used for an increased number of cycles in a subsequent process-friendly manner.

IPC Classes  ?

• C07K 1/22 - Affinity chromatography or related techniques based upon selective absorption processes
• C07K 16/06 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies from serum
• B01J 20/32 - Impregnating or coating

Abstract

The present invention relates to acetylcholine receptor inhibitory peptides and uses thereof, wherein phages with high binding affinity for acetylcholine receptors were screened using a random peptide recombinant phage, and acetylcholine receptor-binding peptides were selected through DNA of the phages. By having confirmed, using the selected peptides, the binding affinity for acetylcholine receptors and the effect of inhibiting the action of acetylcholine receptors, and having confirmed, via the modifications of the peptides, peptide sites and sequences that are vital in binding to acetylcholine receptors, the acetylcholine receptor inhibitory peptides of the present invention are expected to be used in the development of a cosmetic composition for alleviating wrinkles, a medicine for the prevention or treatment of acetylcholine receptor-associated diseases, and a health functional food for the amelioration thereof.

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• A23L 33/18 - PeptidesProtein hydrolysates
• A61K 8/64 - ProteinsPeptidesDerivatives or degradation products thereof
• A61P 25/14 - Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
• A61Q 19/00 - Preparations for care of the skin
• A61K 38/00 - Medicinal preparations containing peptides

Abstract

The present invention relates to a mutated immunoglobulin-binding protein having increased alkaline tolerance and, more specifically, to an immunoglobulin-binding protein in which, with respect to the A-domain of Staphylococcal protein A, or a functional variant thereof, an amino acid at a specific site is mutated and thereby exhibits an increased chemical stability at an alkaline pH value in comparison to a parental molecule. The present invention can provide an antibody-purifying immunoglobulin-binding protein ligand and matrix which have enhanced alkaline tolerance and accordingly enhanced stability in multiple times of alkaline cleaning.

IPC Classes  ?

• C07K 14/31 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
• B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
• C07K 1/12 - General processes for the preparation of peptides by hydrolysis

Abstract

The present invention relates to an acetylcholine receptor-binding peptide and, more particularly, to a novel peptide that blocks the release of acetylcholine by binding to an acetylcholine receptor on which acetylcholine acts, thus exerting a reductive effect on wrinkles. A peptide according to the present invention has strong affinity for an acetylcholine receptor and thus binds strongly to acetylcholine to repress the release of acetylcholine, whereby a cosmetic composition and a pharmaceutical composition, each comprising the peptide of the present invention as an effective ingredient, exhibit superb wrinkle reduction effects.

IPC Classes  ?

• C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
• C07K 7/08 - Linear peptides containing only normal peptide links having 12 to 20 amino acids
• A61K 8/64 - ProteinsPeptidesDerivatives or degradation products thereof
• A61Q 19/08 - Anti-ageing preparations
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
• A61K 38/00 - Medicinal preparations containing peptides

Abstract

Acremonium chrysogenumAcremonium chrysogenumAcremonium chrysogenumAcremonium chrysogenumAcremonium chrysogenumAcremonium chrysogenumAcremonium chrysogenum strain and fermenting the same.

IPC Classes  ?

• C12N 15/80 - Vectors or expression systems specially adapted for eukaryotic hosts for fungi
• C12N 9/80 - Hydrolases (3.) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides
• C12P 35/06 - Cephalosporin CDerivatives thereof

Abstract

The present invention relates to a mutated immunoglobulin-binding protein having increased alkaline tolerance and, more specifically, to an immunoglobulin-binding protein in which, with respect to the A-domain of Staphylococcal protein A, or a functional variant thereof, an amino acid at a specific site is mutated and thereby exhibits an increased chemical stability at an alkaline pH value in comparison to a parental molecule. The present invention can provide an antibody-purifying immunoglobulin-binding protein ligand and matrix which have enhanced alkaline tolerance and accordingly enhanced stability in multiple times of alkaline cleaning.

IPC Classes  ?

• C07K 14/31 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
• C07K 1/22 - Affinity chromatography or related techniques based upon selective absorption processes
• B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography

Abstract

The present invention relates to a collagen hydrolysate with a high content of collagen tripeptides, and the use thereof and, more particularly, to a collagen hydrolysate prepared by using a collagenase that specifically produces a predominant amount of collagen tripeptides and a composition comprising the same as an effective ingredient for preventing hair loss and/or for promoting hair regrowth. Remarkably rich in collagen tripeptide content compared to previously reported collagen hydrates, the collagen hydrolysate of the present invention has an outstanding absorption rate in the body and exhibits an excellent capability of preventing hair loss and promoting hair regrowth and an excellent effect of improving skin wrinkles and/or moisturizing the skin.

IPC Classes  ?

• C07K 14/78 - Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
• C07K 1/12 - General processes for the preparation of peptides by hydrolysis
• C07K 1/18 - Ion-exchange chromatography
• B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
• A23L 33/18 - PeptidesProtein hydrolysates
• A61K 8/65 - CollagenGelatinKeratinDerivatives or degradation products thereof
• A61K 38/01 - Hydrolysed proteinsDerivatives thereof
• A61Q 9/04 - Depilatories

Abstract

The present invention relates to a composition for the prevention or treatment lipid metabolic disorders comprising fucoxanthin or marine plant extract comtaining the same as an effective indredients. Fucoxanthin or a marine plant extract comprising the same is effective in reducing weight increase and reducing triglyceride and cholesterol level in liver tissue, or plasma through inhibiting the synthesis of fatty acid and promoting the oxidation of fatty acid. Therefore, the composition comprising fucoxanthin or a marine plant extract comprising the same as an effective ingredient may be effectively used for the prevention and treatment of lipid metabolic disorders.

IPC Classes  ?

• A61K 31/336 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin