QINGDAO CHENLAND PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO., LTD. (China)
Inventor
Cao, Tingfeng
Fan, Fang
Zou, Shengcan
Feng, Guojunnan
Liu, Jinli
Lu, Xiu
Zhang, Zengliang
Abstract
This application belongs to the field of biotechnology and discloses a method for producing a clam active peptide. The method for producing a clam active peptide comprises cleaning fresh clam meat with water, adding water and homogenizing with a colloid mill to prepare a clam meat slurry; adding water and complex protease for enzymolysis of the clam meat slurry, and heating to inactivate enzyme after the enzymolysis; centrifuging to collect an enzymatic hydrolyzate, capturing the enzymatic hydrolyzate having a molecular weight of lower than 2 KDa through microfiltration-ultrafiltration-nanofiltration membrane filtration, and drying to obtain the clam active peptide. The present disclosure produces a clam active peptide having pure color, outstanding taste, and blood pressure lowering function which is easily absorbed by human body using fresh clam meat as raw material, adopting a complex enzyme-membrane coupling technology through processing techniques such as enzymolysis, membrane separation purification and drying.
Qingdao Chenland Pharmaceutical Technology Development Co., Ltd. (China)
Inventor
Zou, Shengcan
Zhang, Zengliang
Wang, Min
Liu, Zhuqing
Lu, Sai
Li, Li
Wang, Shanglong
Abstract
A multi-efficacy traditional Chinese medicine compound composition and application thereof in pharmaceutical preparations are disclosed. The traditional Chinese medicine extracts are combined with the glucosamine, the collagen and the chondroitin sulfate, so that the multi-efficacy traditional Chinese medicine compound composition is prepared. The traditional Chinese medicine compound composition starts from improving the health of bone and joint and accompanying cardiovascular disease, selects the medicinal materials, and optimizes the extraction process of the traditional Chinese medicine for the diseases dominated by degenerative osteoarthritis. The disclosure has the efficacious of improving the symptoms of degenerative osteoarthritis, reducing blood pressure, improving the symptoms with osteoporosis, improving the symptoms with cardiovascular disease, improving the symptoms with urinary system disease, etc. It also has the characteristics of less dosage, significant curative effect and various functions, which is suitable for market promotion and application.
QINGDAO CHENLAND PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO., LTD. (China)
Inventor
Zou, Shengcan
Zong, Jiancheng
Li, Wenyu
Li, Xin
Zong, Lei
Zhang, Zengliang
Wang, Shanglong
Abstract
Provided are a traditional Chinese medicine compound composition having an anxiolytic effect, and a preparation method and application thereof: compounding extracts separately obtained from Peonia lactiflora, Fructus Gardeniae, Albizia julibrissin flower, and peony bark to prepare a traditional Chinese medicine compound composition having an anxiolytic effect; said traditional Chinese medicine compound composition has no side effects, has remarkable effectiveness, and can be used to treat conditions such as anxiety and agitation and insomnia; furthermore, the traditional Chinese medicine compound composition can be used as a dietary supplement or a health food ingredient, and is used for preventing or treating anxiety disorders and promoting mental health.
Qingdao Chenland Pharmaceutical Technology Development Co., Ltd. (China)
Inventor
Zou, Shengcan
Zong, Jiancheng
Li, Wenyu
Li, Xin
Zong, Lei
Zhang, Zengliang
Wang, Shanglong
Abstract
A traditional Chinese medicine compound composition with anti-anxiety effect and its preparation method and application are disclosed. The traditional Chinese medicine compound composition with anti-anxiety effect is prepared by compounding the Paeoniae Radix Alba extract, the Gardeniae Fructus extract, the Albiziae Flos extract and the Moutan Cortex extract. The traditional Chinese medicine compound composition has no toxic side effects and has remarkable treatment effect, and can be used as a dietary supplement or a health-care food ingredient to prevent and treat anxiety disorder, and promote mental health. It can be seen that the traditional Chinese medicine compound composition is suitable for promotion and application.
QINGDAO CHENLAND PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO., LTD. (China)
Inventor
Zou, Shengcan
Zhang, Zengliang
Zong, Jiancheng
Li, Wenyu
Li, Xin
Li, Li
Wang, Shanglong
Zong, Lei
Abstract
A compound composition having the effect of promoting bone health, which consists of a traditional Chinese medicine extract, chicken cartilage collagen, magnesium, vitamin K2 and vitamin D3. The traditional Chinese medicine extract is a mixture of a Eucommia ulmoides extract, a Davallia mariesii extract and a Cuscuta chinensis Lam. extract, and the traditional Chinese medicine extract is obtained by heating, refluxing and extracting with ethanol. The present invention also relates to a preparation method for the compound composition and an application thereof in the preparation of health foods.
QINGDAO CHENLAND PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO., LTD. (China)
Inventor
Zou, Shengcan
Zong, Jiancheng
Li, Wenyu
Zong, Lei
Zhang, Zengliang
Wang, Shanglong
Abstract
Moutan cortex. The raw materials are weighed in proportion to obtain extracts respectively, and the extracts are mixed to prepare a compound preparation. The compound preparation prepared by the present invention has the advantages of simple preparation, safety, low toxic and side effects, no dependence, etc., and can effectively alleviate depression mood.
Qingdao Chenland Pharmaceutical Technology Development Co., Ltd. (China)
Inventor
Zou, Shengcan
Zhang, Zengliang
Zong, Jiancheng
Li, Wenyu
Li, Xin
Li, Li
Wang, Shanglong
Zong, Lei
Abstract
A compound composition for improving bone health and preparation and application thereof are provided. The compound composition is prepared by combining a traditional Chinese medicine extract with chicken cartilage collagen, magnesium, vitamin K2 and vitamin D3. The compound composition overcomes the food safety risk of the existing osteoporosis preventive drugs by adding the traditional Chinese medicine extract for improving osteoporosis and promoting bone health. And the compound composition disclosed can be used as a dietary supplement or health food raw material for preventing or treating osteoporosis. Therefore, the compound composition disclosed is suitable for promotion and application.
QINGDAO CHENLAND PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO., LTD. (China)
Inventor
Zou, Shengcan
Zhang, Zengliang
Wang, Min
Liu, Zhuqing
Lu, Sai
Li, Li
Wang, Shanglong
Abstract
A traditional Chinese medicine (TCM) compound composition having multiple effects and an application thereof in a pharmaceutical preparation. Only by combining a TCM extract with collagen, chondroitin sulfate and glucosamine can a TCM compound composition having multiple effects be prepared. Said TCM compound composition starts from the aspects of improving bone and joint health and cardiovascular disease, and the components of the prescription are carefully selected. In addition, the TCM is extracted and optimized for degenerative osteoarthritis-based diseases. The present invention further improves the curative effect, and not only has multiple effects such as improving the symptoms of degenerative osteoarthritis, lowering blood pressure, improving symptoms associated with osteoporosis, improving symptoms associated with cardiovascular diseases, and improving diseases associated with the urinary system, but also has the features of low dosage, significant curative effect and diverse functions, and is suitable for market promotion and application.
QINGDAO CHENLAND PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO., LTD. (China)
Inventor
Zou, Shengcan
Zhang, Zengliang
Wang, Min
Lu, Sai
Liu, Zhuqing
Zong, Jiancheng
Wang, Shanglong
Abstract
A compound composition with anti-oxidation and anti-aging effects, formed by mixing a traditional Chinese medicine extract and chitosan oligosaccharide in a weight ratio of (3-8):1. The traditional Chinese medicine extract is formed by individually extracting the following traditional Chinese medicinal materials and then mixing in percentage by weight: 7-15% of ginseng, 14-35% of poria cocos, 14-35% of radix rehmanniae, 14-35% of herba cistanche, 7-15% of radix salviae miltiorrhizae, 0-10% of radix codonopsis, 0-10% of peach seed, and 0-10% of radix ophiopogonis. The compound composition has no toxic and side effects, is easy to absorb, and can be used for delaying aging, repairing DNA damage and resisting oxidative damage, and can reduce risk of age-related diseases, and thus can be used as dietary supplements or health food ingredients to improve the content of telomerase and delay aging, and is suitable for promotion and application.
Qingdao Chenland Pharmaceutical Technology Development Co., Ltd. (China)
Inventor
Zou, Shengcan
Zhang, Zengliang
Wang, Min
Lu, Sai
Liu, Zhuqing
Zong, Jiancheng
Wang, Shanglong
Abstract
A compound composition with anti-oxidation and anti-aging effects and preparation method and application thereof we disclosed. 5-8 kinds of traditional Chinese medicine extracts from separate extraction of Panax ginseng C. A. Meyer, Poria, Rehmannia glutinosa, Cistanche deserticola Ma, Salviae Miltiorrhizae, Codonopsis Radix, Persicae Semen and Ophiopogon japonicus (Linn.f.) Ker-Gawl. are compounded with chitooligosaccharide to prepare the compound composition with anti-oxidation and anti-aging effects. The compound composition has no toxic side effects, is easy to be absorbed, and can be used for delaying aging, repairing DNA damage and anti-oxidation damage, and can also reduce the risk of geriatric diseases. Moreover, the compound composition can be used as a raw material of dietary supplement or health food to improve telomerase content and delay aging. Therefore, the compound composition is suitable for promotion and application.
QINGDAO CHENLAND PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO., LTD. (China)
Inventor
Zou, Shengcan
Wang, Changwei
Wang, Yanmei
Wang, Shanglong
Cao, Tingfeng
Li, Bafang
Abstract
Provided are a method for preparing a sea cucumber protein peptide, and the use thereof. The preparation method comprises removing the viscera from fresh Iceland Red Ginseng, washing same and air-drying same, grinding same into a homogenate, then adding protease for enzymolysis, inactivating the enzyme in a boiling water bath, filtering same, decolorating same and spray-drying same to obtain a sea cucumber protein peptide. The sea cucumber protein peptide can be used as the raw material of a nutritional supplement, a health-care product or a cosmetic product.
C07K 1/34 - ExtractionSeparationPurification by filtration, ultrafiltration or reverse osmosis
C12P 21/06 - Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
12.
TRADITIONAL CHINESE MEDICINE COMPOUND COMPOSITION HAVING EFFECT OF PROMOTING BONE HEALTH AS WELL AS PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
QINGDAO CHENLAND PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO., LTD. (China)
Inventor
Zhang, Zengliang
Zong, Jiancheng
Li, Wenyu
Li, Xin
Li, Li
Wang, Shanglong
Zong, Lei
Zou, Shengcan
Abstract
A traditional Chinese medicine compound composition having the effect of promoting bone health as well as a preparation method therefor and an application thereof. The composition is prepared by compounding extracts obtained by separate extraction of Cortex Eucommiae, Rhizoma Drynariae and Semen Cuscutae. The composition may prevent serum E2 level in rats from reducing, increase bone density and increase the maximum load of the femur, and has the effect of preventing and treating osteoporosis.
QINGDAO CHENLAND PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO., LTD. (China)
Inventor
Cao, Tingfeng
Fan, Fang
Zou, Shengcan
Feng, Guojunnan
Liu, Jinli
Lu, Xiu
Zhang, Zengliang
Abstract
Disclosed is a method for preparing a clam active peptide. The method comprises: washing fresh clam meat with water, and adding water and homogenizing the mixture with colloids to prepare a clam pulp; adding water and a compound protease to the clam pulp for enzymolysis, and after enzymolysis, performing enzyme inactivation by means of heating; and centrifuging the mixture to collect an enzymatic hydrolysate, filtering same via a microfiltration-ultrafiltration-nanofiltration membrane, collecting the enzymatic hydrolysate with a molecular weight below 2 KDa, and drying same to obtain a clam active peptide. The active peptide has an ACE inhibitory activity.
QINGDAO CHENLAND PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO, LTD (China)
Inventor
Zou, Shengcan
Han, Min
Zong, Jiancheng
Zong, Lei
Wang, Shanglong
Li, Xin
Abstract
A curcumin complex, a preparation method therefor and a detection method therefor, the curcumin complex comprising a solid complex formed by grinding an auxiliary material and curcumin, the auxiliary material comprising Soluplus, poloxamer 407, or poloxamer 188; when the auxiliary material comprises the Soluplus, the mass ratio of the curcumin to the Soluplus is 1:8-10; and when the auxiliary material comprises the poloxamer 407 or poloxamer 188, the mass ratio of the curcumin to the poloxamer 407 is 1:0.4-0.6, and the mass ratio of the curcumin to the poloxamer 188 is 1:0.4-0.6. Also disclosed is a preparation method for a curcumin complex. The curcumin complex has high bioavailability and a simple prescription process; in addition, the crystal form of the curcumin is not changed, and not only is quality control more complete and reliable, but costs are also lower, and large-scale production is facilitated.
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61P 39/06 - Free radical scavengers or antioxidants
A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
15.
TRADITIONAL CHINESE MEDICINE COMPOSITION HAVING EFFECT OF IMPROVING COGNITION, PREPARATION METHOD THEREFOR, AND TRADITIONAL CHINESE MEDICINE PREPARATION
QINGDAO CHENLAND PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO., LTD. (China)
Inventor
Zou, Shengcan
Zhang, Zengliang
Li, Xin
Wang, Shanglong
Zong, Lei
Zong, Jiancheng
Abstract
Disclosed are a traditional Chinese medicine composition which has the effect of improving cognition, a preparation method therefor, and a traditional Chinese medicine preparation. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 1 to 20 parts of Gastrodiae rhizoma, 1 to 15 parts of Polygalae radix, 1 to 30 parts of Acori tatarinowii rhizoma, 0.1 to 10 parts of Cistanches herba, 0.1 to 10 parts of Rehmanniae radix preparata, and 0.01 to 1 part of curcumin. A prescription is extracted by means of a composite extraction method, and as many of the pharmacodynamic substances of the Gastrodiae rhizoma, the Polygalae radix, the Acori tatarinowii rhizoma, the Cistanche herba and the Rehmanniae radix preparata are completely extracted, concentrated and dried; and Acori tatarinowii rhizoma volatile oil and the curcumin are included and dried by means of a volatile oil inclusion technique, a traditional Chinese medicine compound extract dry powder and a volatile oil inclusion compound are evenly mixed, and then, the final traditional Chinese medicine composition is obtained. By means of pharmacological experiments, it is proved that compound traditional Chinese medicine has the effect of improving brain cognition.
QINGDAO CHENLAND PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO., LTD. (China)
Inventor
Zou, Shengcan
Zhang, Zengliang
Li, Xin
Wang, Shanglong
Zong, Lei
Zong, Jiancheng
Abstract
Disclosed is an method for establishing a fingerprint spectrum of a traditional Chinese medicine complex having the effect of improving cognition or a preparation thereof. The traditional Chinese medicine complex is prepared from the following raw materials in parts by weight: 1 to 20 parts of Gastrodiae radix, 1 to 15 parts of Polygalae radix, 1 to 30 parts of Acori tatarinowii rhizoma, 0.1 to 10 parts of Cistanche herba, 0.1 to 10 parts of Rehmanniae radix preparata and 0.01 parts to 1 part of curcumin; a spectrum of a test sample solution is constructed by using high-performance liquid chromatography, with the chromatography conditions being as follows: an octadecyl silane chemically bonded silica chromatographic column is used as a chromatographic column; the column temperature is 25 to 35℃; the flow rate is 0.9 to 1.1 mL/min; the detection wavelengths respectively are 210 to 230 nm and 310 to 330 nm; and mobile phase A is acetonitrile, mobile phase B is water, and gradient elution is carried out. The fingerprint spectrum obtained by the method comprehensively reflects quality information of the traditional Chinese medicine complex, so that the aim of more comprehensively and effectively controlling the product quality of the traditional Chinese medicine complex can be achieved.
TRADITIONAL CHINESE MEDICINE EXTRACT COMPOSITION HAVING FUNCTION OF REGULATING DEPRESSION, PREPARATION METHOD THEREFOR, AND CHINESE MEDICINE PREPARATION
QINGDAO CHENLAND PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO., LTD. (China)
Inventor
Zhang, Zengliang
Wang, Shanglong
Li, Wenyu
Zong, Lei
Zong, Jiancheng
Zou, Shengcan
Abstract
Disclosed is a traditional Chinese medicine extract composition having the function of regulating depression, a preparation method therefor, and a Chinese medicine preparation. The composition is composed of the following traditional Chinese medicine extracts, in parts by weight, 40-80 parts of Hypericum perforatum extract, 10-40 parts of Eleutherococcus senticosus extract, and 2-20 parts of Moutan bark extract. The traditional Chinese medicine composition has the functions of relieving depression, aiding sleep, and the like.
QINGDAO CHENLAND PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO., LTD. (China)
Inventor
Zhang, Zengliang
Zou, Shengcan
Li, Wenyu
Wang, Shanglong
Zong, Lei
Zong, Jiancheng
Abstract
Disclosed is a method for establishing a fingerprint spectrum of a traditional Chinese medicine composition having the effect of regulating low mood or a preparation thereof, which method comprises: preparing a traditional Chinese medicine composition from 40 to 80 parts of Hypericum perforatum extract, 10 to 40 parts of Acanthopanacis senticosi radix et rhizoma seu caulis and 2 to 20 parts of Moutan cortex extract; and constructing a spectrum by using high-performance liquid chromatography, with the chromatography conditions being as follows: an octadecyl silane chemically bonded silica chromatographic column is used as a chromatographic column; the column temperature is 25 to 35℃; the flow rate is 0.5 to 1.1 mL/min; the detection wavelength is 290 to 310 nm; and mobile phase A is a phosphoric acid aqueous solution, mobile phase B is acetonitrile, and gradient elution is carried out. The fingerprint spectrum obtained by the method for establishing a fingerprint spectrum of a traditional Chinese medicine composition with effect of regulating low mood comprehensively reflects the quality information of the traditional Chinese medicine composition, so that the aim of more comprehensively and effectively controlling the product quality of the traditional Chinese medicine composition can be achieved.
Qingdao Chenland Pharmaceutical Technology Development Co., Ltd. (China)
Inventor
Zou, Shengcan
Zong, Jiancheng
Li, Wenyu
Zong, Lei
Zhang, Zengliang
Wang, Shanglong
Abstract
The present invention discloses a fingerprint detection method for an antidepressant drug, which adopts liquid chromatography to characterize pharmacological active ingredients of the antidepressant drug composed of Hypericum perforatum L., Paeonia lactiflora Pall, Gardenia jasminoides Ellis, Albizia julibrissin Durazz, and Moutan Cortex, provides an effective detection method, and realizes the quality control of traditional Chinese medicine compositions. The fingerprint detection method provided by the present invention has the advantages of high repeatability and high stability.
B01J 20/286 - Phases chemically bonded to a substrate, e.g. to silica or to polymers
B01J 20/10 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
QINGDAO CHENLAND PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO., LTD. (China)
CHENLAND NUTRITIONALS, INC. (USA)
Inventor
Zou, Shengcan
Li, Li
Zong, Lei
Zong, Jiancheng
Wang, Shanglong
Zhang, Zengliang
Abstract
Disclosed is a complex composition with a function of promoting bone and joint health and an application thereof. The complex composition with the function of promoting bone and joint health can be prepared by combining amino sugar, collagen, chondroitin sulfate, and a traditional Chinese medicine extract. The complex composition can shorten onset time and can be used as a raw material for a dietary supplement or health food to prevent or treat mild to moderate osteoarthritis.
A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives
A23L 33/125 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing carbohydrate syrupsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugarsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugar alcoholsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing starch hydrolysates
QINGDAO CHENLAND PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO., LTD. (China)
CHENLAND NUTRITIONALS, INC. (USA)
Inventor
Zou, Shengcan
Li, Li
Zong, Lei
Zong, Jiancheng
Wang, Shanglong
Zhang, Zengliang
Abstract
A method for the quality control and chromatographic fingerprinting of an epimedium compound product. In the method, high performance liquid chromatography is used, which may effectively achieve the quality control of products containing Chinese medicine ingredients, especially the stable quality control of products containing a large amount of non-Chinese medicine ingredients in the formula. Step-by-step quality control reduces fluctuations in product quality and ensures the stability of quality. Meanwhile, the method is simple and does not require additional instruments, standard products, and so on, which saves on costs and is more conducive to actual production.