Provided are a protein L-derived immunoglobulin binding protein having an increased alkali tolerance, and an affinity support using the same. Disclosed are an immunoglobulin binding protein comprising at least one mutant of an immunoglobulin binding domain, and an affinity support comprising a solid-phase support having the immunoglobulin binding protein bound thereto. A mutant of the immunoglobulin binding domain consists of an amino acid sequence having an identity of at least 85% with the sequence set forth in any one of SEQ ID NO:1 to SEQ ID NO:9 and a predetermined mutation, and the mutant has immunoglobulin κ chain binding activity.
To provide a chromatography carrier that has excellent antifouling properties and exhibits excellent pressure-resistant performance and shatter-resistant performance.
A chromatography carrier comprising: a polymer having a partial structure containing at least two groups represented by —C(═O)—NH—.
B01D 15/10 - Selective adsorption, e.g. chromatography characterised by constructional or operational features
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01J 20/28 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof characterised by their form or physical properties
C07K 1/22 - Affinity chromatography or related techniques based upon selective absorption processes
C07K 16/32 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products from oncogenes
3.
Composite particles, coated particles, method for producing composite particles, ligand-containing solid phase carrier and method for detecting or separating target substance in sample
The present invention relates to composite particles, coated particles, a method of producing composite particles, a ligand-containing solid phase carrier, and a method of detecting or separating a target substance in a sample. The above described composite particles each contains an organic polymer and inorganic nanoparticles, wherein the content of the inorganic nanoparticles in the composite particles is more than 80% by mass, and wherein the composite particles have a volume average particle size of from 10 to 1,000 nm.
H01F 41/02 - Apparatus or processes specially adapted for manufacturing or assembling magnets, inductances or transformersApparatus or processes specially adapted for manufacturing materials characterised by their magnetic properties for manufacturing cores, coils or magnets
H01F 1/36 - Magnets or magnetic bodies characterised by the magnetic materials thereforSelection of materials for their magnetic properties of inorganic materials characterised by their coercivity of soft-magnetic materials non-metallic substances, e.g. ferrites in the form of particles
H01F 1/00 - Magnets or magnetic bodies characterised by the magnetic materials thereforSelection of materials for their magnetic properties
Provided are an additive and a surface treatment agent capable of suppressing agglutination of latex particles contained in a reagent for a latex agglutination reaction during storage of the reagent although a synthetic polymer is contained as an active component.
An additive is to be added to latex particles used in a reagent for a latex agglutination reaction. The latex particles have not been subjected to blocking treatment. The additive includes a polymer containing more than 60% by mass and 99% by mass or less of hydrophilic repeating units (A) relative to all repeating units and 1% by mass or more and less than 40% by mass of hydrophobic repeating units (B) relative to all repeating units, and having a weight average molecular weight of 3,000 or more.
Provided are a protein L-derived immunoglobulin binding protein having an increased antibody dissociation rate under acidic conditions, and an affinity support using the same. Disclosed are an immunoglobulin binding protein comprising at least one mutant of an immunoglobulin binding domain, and an affinity support comprising a solid-phase support having the immunoglobulin binding protein bound thereto. A mutant of the immunoglobulin binding domain consists of an amino acid sequence having an identity of at least 85% with the sequence set forth in any one of SEQ ID NO:1 to SEQ ID NO:9 and a predetermined mutation, and the mutant has immunoglobulin κ chain binding activity.
C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
C07K 1/22 - Affinity chromatography or related techniques based upon selective absorption processes
C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01J 20/00 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof
B01J 20/30 - Processes for preparing, regenerating or reactivating
B01J 20/24 - Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives
To provide a novel technique with which the generation of aggregates over time in a dispersion liquid can be suppressed and a target substance can be detected with high sensitivity even if latex particles that have been stored are used. A method for storing in a container a latex particle dispersion liquid in which latex particles for an extracorporeal diagnostic agent are dispersed, the latex particles having a volume average particle size of 10 to 1000 nm and including a polymer containing 70 to 100% by mass of monomer units each derived from a monomer having an aryl group relative to the total monomer units, which is characterized in that the particle dispersion liquid is stored in the container by setting a ratio of a volume of a void space obtained by excluding a volume occupied by the particle dispersion liquid from an internal volume of the container to 0 to 25% (v/v) relative to the internal volume of the container.
The present invention relates to a magnetic particle dispersion, and the magnetic particle dispersion includes a magnetic particle, an isothiazoline compound, and an aqueous medium.
C07D 275/03 - Heterocyclic compounds containing 1, 2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C07D 275/04 - Heterocyclic compounds containing 1, 2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
C07D 275/02 - Heterocyclic compounds containing 1, 2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
in vivoin vivo observation. The hydrophilized dye-containing particles are for imaging, and contain a hydrophilic polymer and a fluorescent dye that emits fluorescent light having a wavelength within a range of 900 to 1700 nm.
A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
B82Y 40/00 - Manufacture or treatment of nanostructures
9.
METHOD FOR SEPARATING CELLS, AND PARTICLES AND KIT FOR CELL SEPARATION OR CONCENTRATION
One embodiment of the present invention relates to a method for separating cells, and to particles and a kit for cell separation or concentration. Said method is for separating target cells or non-target cells and comprises the following steps 1 and 2. The following organic polymer-containing magnetic particles comprise an organic polymer and magnetic particles. The content of the magnetic particles in the organic polymer-containing magnetic particles is ≥40 mass%. The volume-average particle diameter of the organic polymer-containing magnetic particles is 10-1000 nm. Step 1 is for bringing a material containing the target cells into contact with organic polymer-containing magnetic particles. Step 2 is for magnetically separating complexes of organic polymer-containing magnetic particles and target cells or non-target cells that are produced in step 1.
A protein L-derived immunoglobulin binding protein with improved alkali resistance, and an affinity support using the same are provided. This immunoglobulin binding protein contains at least one mutant of an immunoglobulin binding domain, and this affinity support includes a solid-phase support to which said immunoglobulin binding protein is bonded. The mutant of the immunoglobulin binding domain is formed from an amino acid sequence which is at least 85% identical with an amino acid sequence represented in any of sequence numbers 1 to 9 and which has a given mutation, and said mutant has immunoglobulin κ-chain binding activity.
A protein L-derived immunoglobulin binding protein with an improved antibody dissociation rate under acidic conditions, and an affinity support using the same are provided. This immunoglobulin binding protein contains at least one mutant of an immunoglobulin binding domain, and this affinity support includes a solid-phase support to which said immunoglobulin binding protein is bonded. The mutant of the immunoglobulin binding domain is formed from an amino acid sequence which is at least 85% identical with an amino acid sequence represented in any of sequence numbers 1 to 9 and which has a given mutation, and said mutant has immunoglobulin κ-chain binding activity.
C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01J 20/24 - Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives
B01J 20/30 - Processes for preparing, regenerating or reactivating
C07K 1/22 - Affinity chromatography or related techniques based upon selective absorption processes
C12N 1/15 - Fungi Culture media therefor modified by introduction of foreign genetic material
C12N 1/19 - YeastsCulture media therefor modified by introduction of foreign genetic material
C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
C12N 15/31 - Genes encoding microbial proteins, e.g. enterotoxins
C12N 15/63 - Introduction of foreign genetic material using vectorsVectorsUse of hosts thereforRegulation of expression
C12P 21/02 - Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
12.
CHROMATOGRAPHY CARRIER, LIGAND-IMMOBILIZING CARRIER, CHROMATOGRAPHY COLUMN, TARGET SUBSTANCE PURIFICATION METHOD, AND CHROMATOGRAPHY CARRIER PRODUCTION METHOD
The present invention provides a chromatography carrier that has excellent antifouling properties and exhibits excellent pressure-resistant and fracture-resistant performance. This chromatography carrier comprises a polymer having a partial structure that includes at least two groups represented by -C(=O)-NH-.
B01D 15/00 - Separating processes involving the treatment of liquids with solid sorbentsApparatus therefor
B01D 15/38 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups , e.g. affinity, ligand exchange or chiral chromatography
B01J 20/24 - Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives
B01J 20/281 - Sorbents specially adapted for preparative, analytical or investigative chromatography
B01J 20/30 - Processes for preparing, regenerating or reactivating
C07K 1/16 - ExtractionSeparationPurification by chromatography
G01N 30/88 - Integrated analysis systems specially adapted therefor, not covered by a single one of groups
13.
PROTEIN, AND ISOLATION METHOD FOR ANTIBODIES OR FRAGMENTS THEREOF USING CARRIER INCLUDING SAID PROTEIN
Provided is a carrier for affinity chromatography having high immunoglobulin purification efficiency. This protein contains two or more domains linked together by a linker. The domains have affinity to immunoglobulins. The linker is a peptide having a rod-shaped structure, or the linker includes (a) a linker comprising a polypeptide containing at least one proline and/or (b) a linker comprising a polypeptide including at least one peptide unit comprising Xaii-Xbor Xbii-Xa(where Xarepresents an acidic amino acid, Xb represents a basic amino acid, A represents alanine, and i represents an integer of 3 or 4).
C07K 1/22 - Affinity chromatography or related techniques based upon selective absorption processes
C07K 14/31 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
C07K 17/02 - Peptides being immobilised on, or in, an organic carrier
C12N 1/15 - Fungi Culture media therefor modified by introduction of foreign genetic material
C12N 1/19 - YeastsCulture media therefor modified by introduction of foreign genetic material
C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
G01N 30/88 - Integrated analysis systems specially adapted therefor, not covered by a single one of groups
14.
METHOD FOR DETECTING OR MEASURING IMMUNE AGGLUTINATION
Provided is a novel means capable of detecting or measuring immune agglutination with high sensitivity and high accuracy. Disclosed is a method for detecting or measuring immune agglutination, the method comprising the following steps 1 and 2. Step 1: a specimen dilute solution preparation step for obtaining a specimen dilute solution by bringing, into contact with one another, a specimen that may include a target substance, a diluting liquid, and a polymer that includes a repeating unit (A) including a group represented by formula (1) in a side chain thereof. Step 2: a mixing step for mixing the specimen dilute solution and particles to which an antigen or antibody to the target substance is fixed. (In formula (1), R12-82-8 alkylene group, R21-401-40 organic group, and n represents 2 or greater on average.)
JAPAN AS REPRESENTED BY DIRECTOR-GENERAL OF NATIONAL INSTITUTE of INFECTIOUS DISEASES (Japan)
JSR LIFE SCIENCES CORPORATION (Japan)
Inventor
Naruse, Hidenori
Itou, Atsushi
Ikawa, Shigeru
Shimokawa, Tsutomu
Suzuki, Masato
Matsui, Mari
Suzuki, Satowa
Shibayama, Keigo
Ikkyuu, Kazuhiro
Abstract
6 each independently represent a hydrogen atom, or a substituted or unsubstituted hydrocarbon group), or a substituted or unsubstituted nitrogen-containing heterocyclic group, and X represents a single bond, or a divalent linking group.]
C08G 81/02 - Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers at least one of the polymers being obtained by reactions involving only carbon-to-carbon unsaturated bonds
This invention relates to a method of producing a probe-bound carrier, a probe-bound carrier and a method of detecting or separating a target substance. The method of producing a probe-bound carrier includes: step 1 of mixing a carrier having tosyl groups and a probe; and step 2 of reducing the amount of tosyl groups on a surface of a carrier, in which a proportion of area S2 that is occupied by one tosyl group on a surface of the carrier obtained in the step 2 with respect to area S1A that is occupied by one tosyl group on a surface of the carrier used in the step 1 (S2/S1A×100%) is not less than 140%.
(B) a repeating unit which has a polyoxyalkylene group in a side chain whose terminal is constituted by an alkyl group having 5 to 30 carbon atoms, an alkanoyl group having 5 to 30 carbon atoms, or an aryl group having 6 to 30 carbon atoms.
C08F 220/36 - Esters containing nitrogen containing oxygen in addition to the carboxy oxygen
C09D 4/00 - Coating compositions, e.g. paints, varnishes or lacquers, based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond
C09D 133/26 - Homopolymers or copolymers of acrylamide or methacrylamide
A61L 31/14 - Materials characterised by their function or physical properties
A61L 17/14 - Post-treatment to improve physical properties
C08F 216/12 - Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal, or ketal radical by an ether radical
C08F 220/28 - Esters containing oxygen in addition to the carboxy oxygen containing no aromatic rings in the alcohol moiety
C08F 299/08 - Macromolecular compounds obtained by interreacting polymers involving only carbon-to-carbon unsaturated bond reactions, in the absence of non-macromolecular monomers from unsaturated polycondensates from polysiloxanes
A61L 27/16 - Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
(B) a repeating unit having a polyoxyalkylene group in a side chain, the terminal of the side chain being composed of an alkyl group having 5 to 30 carbon atoms, an alkanoyl group having 5 to 30 carbon atoms, or an aryl group having 6 to 30 carbon atoms.
G02B 1/04 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements made of organic materials, e.g. plastics
C09D 5/00 - Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects producedFilling pastes
C09D 133/14 - Homopolymers or copolymers of esters of esters containing halogen, nitrogen, sulfur or oxygen atoms in addition to the carboxy oxygen
C09D 133/24 - Homopolymers or copolymers of amides or imides
C09D 139/06 - Homopolymers or copolymers of N-vinyl-pyrrolidones
C10M 107/28 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds containing monomers having an unsaturated radical bound to a carboxyl radical, e.g. acrylate
C10M 107/42 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
C10M 107/48 - Lubricating compositions characterised by the base-material being a macromolecular compound containing phosphorus
C10N 50/08 - Form in which the lubricant is applied to the material being lubricated solid
20.
Solid-phase support, ligand-binding solid-phase support, method for detecting or separating target substance, and method for producing the solid-phase support
The objective of the present invention is to provide a new technique which is capable of suppressing the generation over time of an agglutination in a dispersion liquid, and which allows a target substance to be detected with high sensitivity, even using latex particles that have been stored. A method of storing in a container a latex particle dispersion liquid which contains a polymer including 70 to 100 mass% of a monomer unit derived from a monomer having an aryl group relative to all monomer units, and in which are dispersed latex particles for extracorporeal diagnosis having a volume mean particle size of 10 to 1,000 nm is characterized in that the latex particle dispersion liquid is stored in the container in such a way that the proportion by volume of a void portion obtained by excluding a volume occupied by the particle dispersion liquid from the internal capacity of the container is 0 to 25% (v/v) of the internal capacity of the container.
The present invention provides a magnetic particle dispersion, said magnetic particle dispersion containing magnetic particles, an isothiazoline compound, and an aqueous medium.
Staphylococcus aureus protein A, in which at least one amino acid residue is inserted between positions corresponding to the 3-position and position 4 of the amino acid sequence of the B domain, Z domain or C domain.
C07K 14/31 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
C07K 1/22 - Affinity chromatography or related techniques based upon selective absorption processes
C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
C07K 17/04 - Peptides being immobilised on, or in, an organic carrier entrapped within the carrier, e.g. gel, hollow fibre
The purpose of the present invention is to provide a method for analyzing a nucleic acid in a vesicle, which rarely undergoes the reduction in accuracy caused by the existance of a substance other than an analyte such as a free nucleic acid. A method for analyzing a nucleic acid, comprising a vesicle capturing step of bringing a biological sample containing a vesicle containing a nucleic acid into contact with a capturing carrier for capturing the vesicle to thereby capture the vesicle, said method being characterized in that the vesicle capturing step is carried out by adding a polymer having an acidic group to the system.
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
G01N 33/538 - ImmunoassayBiospecific binding assayMaterials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by sorbent column, particles or resin strip
25.
COMPOSITE PARTICLES, COATED PARTICLES, METHOD FOR PRODUCING COMPOSITE PARTICLES, LIGAND-CONTAINING SOLID PHASE CARRIER, AND METHOD FOR DETECTING OR SEPARATING TARGET SUBSTANCE IN SAMPLE
The present invention pertains to: composite particles; coated particles; a method for producing composite particles; a ligand-containing solid phase carrier; and a method for detecting or separating a target substance in a sample. The composite particles contain an organic polymer and inorganic nanoparticles. The composite particles contain the inorganic nanoparticles in an amount exceeding 80% by mass, and have a volume average particle diameter of 10-1000 nm.
Provided is a solid phase carrier which has high water dispersibility, allows facilitated binding of a ligand to a reactive functional group, and exhibits suppressed non-specific adsorption, and with which, in the case of using the solid phase carrier by having a ligand bound thereto, for example, detection of a target substance can be carried out with high sensitivity and low noise. Disclosed is a solid phase carrier having bound thereto a polymer including a structural unit represented by the following Formula (1) and a structural unit represented by the following Formula (2):
wherein in Formula (1),
1 represents a hydrogen atom or a methyl group; and
2 represents an organic group having a zwitterionic structure,
in Formula (2),
3 represents a hydrogen atom or a methyl group
5 in Formula (2)), or a phenylene group;
5 represents an organic group having a reactive functional group,
5 is not an organic group having a zwitterionic structure.
G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
G01N 33/547 - Synthetic resin with antigen or antibody attached to the carrier via a bridging agent
C08F 293/00 - Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
C08F 257/02 - Macromolecular compounds obtained by polymerising monomers on to polymers of aromatic monomers as defined in group on to polymers of styrene or alkyl-substituted styrenes
C08L 43/02 - Homopolymers or copolymers of monomers containing phosphorus
27.
POROUS CARRIER FOR AFFINITY CHROMATOGRAPHY, LIGAND-CONJUGATED POROUS CARRIER, PURIFICATION METHOD OF TARGET, AND ANTIBODY
Provided is a porous carrier which is for affinity chromatography and has excellent balance between hardness and toughness. The porous carrier for affinity chromatography comprises a polymer having a monomer unit (component A) derived from a polyvinyl monomer and a monomer unit (component B) having an alkyl group having 1-8 carbon atoms in the side chain thereof, and is characterized in that the mass ratio [(A):(B)] between component A and component B contained in the polymer is 95:5-50:50 and the content of component A is 0.5-40 mass% with respect to the entirety of the monomer units in the polymer.
Provided are an additive and a surface treatment agent with which it is possible to suppress the agglutination of latex particles contained in a reagent for a latex agglutination reaction during storage of the reagent, irrespective of whether a synthetic polymer is used as an active component. An additive for addition to latex particles used in a reagent for a latex agglutination reaction, wherein: the latex particles have not undergone a blocking process; hydrophilic repeating units (A) constitute over 60% by mass and no more than than 99% by mass of all repeating units in the additive, and hydrophobic repeating units (B) constitute at least 1% by mass and less than 40% by mass of all repeating units in the additive; and the additive includes a polymer having a weight-average molecular weight of 3,000 or higher.
JAPAN AS REPRESENTED BY DIRECTOR-GENERAL OF NATIONAL INSTITUTE OF INFECTIOUS DISEASES (Japan)
JSR LIFE SCIENCES CORPORATION (Japan)
Inventor
Naruse, Hidenori
Itou, Atsushi
Ikawa, Shigeru
Shimokawa, Tsutomu
Suzuki, Masato
Matsui, Mari
Suzuki, Satowa
Shibayama, Keigo
Ikkyuu, Kazuhiro
Abstract
To provide a polymer having antibacterial/disinfectant properties against a wide range of types of germs. A polymer having a polymer chain having repeating units represented by formula (1), and a partial structure (excluding the polymer chain) derived from a compound including a group represented by –NH-. [In formula (1), R1 represents a hydrogen atom or a methyl group, Z represents a group forming an organic ammonium salt, -NR5R6 (where R5 and R6 each independently represent a hydrogen atom or a substituted or unsubstituted hydrocarbon group), or a substituted or unsubstituted nitrogen-containing heterocyclic group, and X represents a single bond or a divalent linking group.]
A01N 37/12 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group , wherein Cn means a carbon skeleton not containing a ringThio-analogues thereof
Solid support, ligand-bound solid support, detection or separation method for target substance, solid support production method, and ligand-bound solid support production method
To provide a solid-phase carrier to which impurities are hard to nonspecifically adsorb. A solid-phase carrier, formed by binding a chain polymer, wherein the chain polymer comprises a random polymer structure containing a first structural unit having a reactive functional group, and a second structural unit having no reactive functional group or having a reactive functional group having a reactivity lower than that of the reactive functional group of the first structural unit, and the content ratio of the number of moles “a” of the reactive functional group contained in the first structural unit to the number of moles “b” of the entire structural unit contained in the chain polymer, (a/b), is from 0.01 to 0.7.
To provide a solid-phase carrier that has extremely low nonspecific adsorption of biological substances such as proteins, peptides, nucleic acids and cells, and is capable of maintaining the activity of bound ligands at a high level; and a method for capturing a target substance using the solid-phase carrier.
A method for capturing a target substance, including: a step for preparing a solid-phase carrier for capturing a target substance, the carrier having a base material, at least a portion of the surface thereof being formed of or coated with a saccharide, and having a linker of 5-100 atoms having a reactive functional group for binding a ligand that specifically binds to the target substance, wherein the saccharide is chemically bound to the linker; a step for binding the ligand to the solid-phase carrier to obtain a solid-phase carrier having a ligand bound thereto; and a step for bringing the solid-phase carrier having the ligand bound thereto into contact with a sample containing the target substance that specifically binds to the ligand.
The present invention relates to: a composition; a contact lens coating agent; a method for producing a contact lens; and a contact lens. This composition contains: a polymer that has a repeating unit (A) having an HLB value of 14 or more and a repeating unit (B) having an HLB value of 1 or more but less than 14; and a bactericidal compound having a cationic group.
C08L 101/00 - Compositions of unspecified macromolecular compounds
A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
C08L 53/00 - Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bondsCompositions of derivatives of such polymers
C09D 201/00 - Coating compositions based on unspecified macromolecular compounds
(B) a repeating unit having a polyoxyalkylene group in a side chain and having the end of the side chain formed from an alkyl group having 5 to 30 carbon atoms, an alkanoyl group having 5 to 30 carbon atoms, or an aryl group.
G02B 1/04 - Optical elements characterised by the material of which they are madeOptical coatings for optical elements made of organic materials, e.g. plastics
The present invention relates to a polymer composition, an article, a medical device, an article production method, and a cell cluster production method. The polymer composition includes a polymer having the following repeating unit (A) and repeating unit (B), and is one selected from the group consisting of medical device compositions, cell adhesion preventive agents, and silicone substrate treatment compositions. (A) A hydrophilic repeating unit. (B) A repeating unit having a polyoxyalkylene group on a side chain thereof, wherein the end of said side chain is formed from a C5-30 alkyl group, a C5-30 alkanoyl group, or a C6-30 aryl group.
The present invention relates to a method for producing a medical device and a medical device. The production method comprises a step for heating a device together with a liquid containing a polymer having repeating units (A) and repeating units (B) or a step for bringing a device into contact with a heated solution containing a polyemer having repeating units (A) and repeating units (B). Repeating units (A) are hydrophilic repeating units and repeating units (B) are repeating units having polyoxyalkylene groups in the side chain formed from C5-30 alkyl groups, C5-30 alkanoyl groups, or C6-30 aryl groups.
Provided is an affinity support with improved ligand binding to a target substance. Provided is an affinity support, including a solid phase support and a protein ligand, in which the protein ligand is represented by formula (1): R-R1 (in formula (1), R is a linker including polyproline, which chemically bonds with the solid phase support, and R1 indicates a protein demonstrating an affinity for an immunoglobulin, wherein R is bonded to the C-terminal or the N-terminal of the amino acid sequence of R1).
The present invention relates to a method for producing a medical device and a medical device. The production method comprises a step for heating a device together with a liquid containing a polymer having repeating units (A) and repeating units (B) or a step for bringing a device into contact with a heated solution containing a polyemer having repeating units (A) and repeating units (B). Repeating units (A) are hydrophilic repeating units and repeating units (B) are repeating units having polyoxyalkylene groups in the side chain formed from C5-30 alkyl groups, C5-30 alkanoyl groups, or C6-30 aryl groups.
The present invention relates to a method for assaying soluble GPC3 protein in a test sample, comprising using two different antibodies binding to different epitopes present in the N-terminal region of GPC3 protein.
G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer
C07K 16/30 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
A61K 39/00 - Medicinal preparations containing antigens or antibodies
39.
GEL, GEL MANUFACTURING METHOD, LENS, CONTACT LENS SURFACE MODIFIER, POLYMERIZABLE COMPOSITION, AND POLYMER
Provided is a gel that has excellent surface hydrophilicity, lubricity, and antifouling property, and that is useful as a contact lens material or the like. This gel is characterized by containing a polymer a having 2.5-95 mass% of repeat unit (A) and 2.5-95 mass% of repeat unit (B), and a polymer b obtained through polymerization of a hydrophilic monomer with a crosslinking agent. (A): A hydrophilic repeat unit. (B) A repeat unit having a polyoxyalkylene group at a side chain thereof, wherein the terminal of the side chain is formed of an alkyl group having 5-30 carbon atoms, an alkanoyl group having 5-30 carbon atoms, or an aryl group.
Separation method, detection method, signal measurement method, method for determining disease, method for evaluating drug efficacy of disease treatment drug, kit, and liquid composition
A method for separating a vesicle having a lipid bilayer membrane from a biological sample, includes forming a complex of a vesicle and a solid phase carrier by bringing the biological sample containing the vesicle having the lipid bilayer membrane into contact with the solid phase carrier to which a ligand for recognizing a surface antigen present on a surface of the vesicle is bound. The complex is washed. The forming is performed in the presence of a nonionic surfactant which does not comprise an aromatic group to reduce an aggregation of the complex.
Provided is a method which makes it possible to reduce nonspecific adsorption to a solid-phase carrier, and to selectively and efficiently separate vesicles having a lipid bilayer. This method for separating vesicles having a lipid bilayer includes: a composite formation step for forming a composite comprising a vesicle and a solid-phase carrier, by contacting a biological specimen that contains a vesicle having a lipid bilayer with a solid-phase carrier to which a ligand is bonded that recognizes a surface antigen present on the vesicle surface; and a cleaning step for cleaning the composite. The method is characterized by performing the composite formation step and/or the cleaning step in an environment having a salt concentration of 0.15-2M.
Provided is an affinity chromatography carrier in which high immunoglobulin-binding capacity and alkali resistance are maintained. Provided is an immunoglobulin-binding protein, wherein: the immunoglobulin-binding protein contains at least one modified immunoglobulin-binding domain; and the modified immunoglobulin-binding domain is a polypeptide comprising an amino acid sequence having at least one amino acid residue inserted between positions corresponding to 3 and 4 of the amino acid sequence of the B domain, Z domain, or C domain in an amino acid sequence of an immunoglobulin-binding domain selected from the group consisting of the B domain, Z domain, C domain, and variants thereof of Staphylococcus aureus protein A.
C07K 1/22 - Affinity chromatography or related techniques based upon selective absorption processes
C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria
C07K 17/04 - Peptides being immobilised on, or in, an organic carrier entrapped within the carrier, e.g. gel, hollow fibre
C12N 1/15 - Fungi Culture media therefor modified by introduction of foreign genetic material
C12N 1/19 - YeastsCulture media therefor modified by introduction of foreign genetic material
C12N 1/21 - BacteriaCulture media therefor modified by introduction of foreign genetic material
C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
C12P 21/02 - Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
43.
SOLID-PHASE SUPPORT, LIGAND-BONDING SOLID-PHASE SUPPORT, TARGET-SUBSTANCE DETECTING OR SEPARATING METHOD, AND METHOD OF MANUFACTURING SOLID-PHASE SUPPORT
Provided is a solid-phase support that can be manufactured by means of a simple method, that is unlikely to exhibit non-specific adsorption, and that exhibits an excellent target-substance capturing capability when bonded with a ligand. The present invention is a solid-phase support characterized in that at least a solid-phase surface is formed of a copolymer including the following structural units (A) to (C): (A) a structural unit that is derived from monomers having zwitterion structures and that is contained at 1 to 35 % by mass relative to all structural units; (B) a structural unit that is derived from monomers having functional groups capable of chemically bonding with ligands and that is contained at 70 % or less by mass relative to all structural units; and (C) a structural unit that is derived from slightly water-soluble monomers having no functional group capable of chemically bonding with ligands.
SEPARATION METHOD, DETECTION METHOD, SIGNAL MEASUREMENT METHOD, METHOD FOR DETERMINING DISEASE, METHOD FOR EVALUATING DRUG EFFICACY, KIT, LIQUID COMPOSITION, AND ANALYTE DILUENT
The purpose of the present invention is to provide a method by which non-specific adsorption to a solid-phase carrier can be reduced, and vesicles having lipid bilayer membranes can be separated selectively and efficiently. Provided is a method for separating vesicles having lipid bilayer membranes, characterized by including a complex formation step for bringing a biological specimen that includes vesicles having lipid bilayer membranes, and a solid-phase carrier to which are bonded ligands that recognize a surface antigen present on the surfaces of the vesicles, into contact, causing a complex of the vesicles and the solid-phase carrier to form, and a washing step for washing the complex, the complex formation step and/or the washing step being carried out in the presence of an inorganic salt or organic salt at a final concentration of 0.15-2 M.
G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving nucleic acids
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids
45.
Surface treatment agent for surface configured from inorganic material, tool and device having modified surface, and method for manufacturing tool and device
A surface treatment method for treating a surface formed of an inorganic material by using a polymer is provided. The polymer contains a repeating unit (A) having a cationic group with a particular structure in a side chain thereof and a repeating unit (B) having a group of a particular structure in a side chain thereof. Also provided are a tool and a device having a modified surface, and a method for producing the tool and the device.
C03C 17/32 - Surface treatment of glass, e.g. of devitrified glass, not in the form of fibres or filaments, by coating with organic material with synthetic or natural resins
C08F 220/28 - Esters containing oxygen in addition to the carboxy oxygen containing no aromatic rings in the alcohol moiety
Provided is a method of preparing spheroids by which spheroids including, as a main component, cells derived from primary cancer cells are obtained by inhibiting the proliferating ability of cells having a rapid proliferation rate and by providing a culturing environment favorable for culturing cancer cells, in tissue in which the cells having a rapid proliferating rate have been incorporated. The method for preparing spheroids of primary cancer cells is characterized by including the steps for: preparing a culture medium including at least 1 vol% of serum with respect to the total volume thereof; preparing a cell culture substrate on which a treatment for inhibiting adhesiveness to cells is performed; isolating cells from a tissue fragment including cancer cells; and seeding the cells on the cell culture substrate in the culture medium and culturing the cells.
The present invention provides a germicidal composition in which a decrease in germicidal performance due to adsorption of a germicidal compound on a wall surface is minimized. A germicidal composition characterized in containing: at least one polymer selected from a water-soluble polymer (I) having a hydrophilic repeating unit (A) and a hydrophobic repeating unit (B) that has an HLB value of 1-15, and a water-soluble polymer (II) having a repeating unit (C) that has an acidic group and a repeating unit (D) derived from a (meth)acrylamide monomer; and a germicidal compound having a cationic group.
A01N 25/00 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests
Provided is a solid phase carrier which exhibits high water dispersibility, in which ligands readily bond to a reactive functional group, in which non-specific adsorption is suppressed, and by which detection or the like of a target substance can be carried out with high sensitivity and low noise when a ligand is bound thereto. The solid phase carrier is obtained by binding a polymer, which contains a structural unit represented by formula (1) and a structural unit represented by formula (2). (In formula (1), R1 denotes a hydrogen atom or a methyl group, and R2 denotes an organic group having a zwitterion structure) (In formula (2), R3 denotes a hydrogen atom or a methyl group, R4 denotes -(C=O)-O-* or -(C=O)-NR6-*(therein, R6 denotes a hydrogen atom or a methyl group and * denotes the site that bonds to R5 in formula (2)) or a phenylene group, R5 denotes a hydrogen atom or an organic group having a reactive functional group in cases where R4 is -(C=O)-O-*, and R5 denotes an organic group having a reactive functional group in cases where R4 is -(C=O)-NR6-* or a phenylene group, with the proviso that R5 is not an organic group having a zwitterion structure.)
G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
C08F 257/02 - Macromolecular compounds obtained by polymerising monomers on to polymers of aromatic monomers as defined in group on to polymers of styrene or alkyl-substituted styrenes
C08F 293/00 - Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
G01N 33/547 - Synthetic resin with antigen or antibody attached to the carrier via a bridging agent
49.
Solid-phase support, ligand-binding solid-phase support, method for detecting or separating target substance, and method for producing the solid-phase support
JAPAN AS REPRESENTED BY DIRECTOR-GENERAL OF NATIONAL INSTITUTE OF INFECTIOUS DISEASES (Japan)
JSR LIFE SCIENCES CORPORATION (Japan)
Inventor
Naruse, Hidenori
Imoto, Hiroaki
Itou, Atsushi
Shimokawa, Tsutomu
Suzuki, Masato
Matsui, Mari
Suzuki, Satowa
Shibayama, Keigo
Ikkyuu, Kazuhiro
Abstract
In order to provide an antibacterial and/or sterilizing agent having excellent antibacterial properties and sterilizing properties even at low concentration, the present invention provides an antibacterial agent, sterilizing agent, or antibacterial and sterilizing agent having a repeat unit represented by formula (1) and a repeat unit represented by formula (2), and having as an active component a copolymer having an Mw (Mw denoting weight average molecular weight in terms of polystyrene, measured by gel permeation chromatography, wherein the mobile phase in the gel permeation chromatography is tetrahydrofuran.) of 3,000 or less. [In formula (1), R1 represents a hydrogen atom or methyl group, Z represents a group forming an organic ammonium salt, -NR5R6 (R5 and R6 each independently representing hydrogen atoms, or substituted or unsubstituted hydrocarbon groups.), or substituted or unsubstituted nitrogen-containing heterocyclic groups, and X represents a single-bond or divalent linking group.] [In formula (2), R7 represents a hydrogen atom or methyl group, and A represents an aromatic hydrocarbon group, -(C=O)OR8, -(C=O)NHR9, or -OR10 (R8-R10 representing a hydrocarbon group or a group having a chain or cyclic ether structure.)]
A01N 61/00 - Biocides, pest repellants or attractants, or plant growth regulators containing substances of unknown or undetermined composition, e.g. substances characterised only by the mode of action
The purpose of the present invention is to provide a carrier for affinity chromatography that has excellent storage stability and minimizes the reduction of dynamic binding capacity caused by long-term storage and the nonspecific adsorption of impurities. The carrier for affinity chromatography comprises: a solid-phase carrier containing a copolymer that comprises, relative to all the structural units, between >20 and ≤99.5 parts by mass of a structural unit (M-1) derived from an epoxy-group–containing monovinyl monomer, and between ≥0.5 and ≤80 parts by mass of a structural unit (M-2) derived from a polyvinyl monomer; a ring-opened epoxy group obtained by ring-opening an epoxy group; and a ligand bound to the solid-phase carrier. The carrier for affinity chromatography is characterized in that, when the carrier for affinity chromatography is filled into an arbitrary column container and the column is substituted with 20 mM of a sodium phosphate buffer solution of pH 7.5 that contains 2 M of NaCl, the pH inside the column increases by at most 2 after the container is left to stand for 7 days at 40°C.
C07K 1/22 - Affinity chromatography or related techniques based upon selective absorption processes
B01D 15/08 - Selective adsorption, e.g. chromatography
B01J 20/24 - Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives
G01N 30/26 - Conditioning of the fluid carrierFlow patterns
G01N 30/88 - Integrated analysis systems specially adapted therefor, not covered by a single one of groups
C07K 16/00 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies
52.
SOLID SUPPORT, LIGAND-BOUND SOLID SUPPORT, DETECTION OR SEPARATION METHOD FOR TARGET SUBSTANCE, SOLID SUPPORT PRODUCTION METHOD, AND LIGAND-BOUND SOLID SUPPORT PRODUCTION METHOD
Provided is a solid support to which contaminants do not easily non-specifically adhere. A solid support that has a linear polymer bound thereto. The solid support is characterized in that the linear polymer contains a random polymer structure that includes a first structural unit that has a reactive functional group and includes a second structural unit that does not have a reactive functional group or that has a reactive functional group that is less reactive than the reactive functional group of the first structural unit, the content ratio (a/b) of the number of moles (a) of the reactive functional group included in the first structural unit and the number of moles (b) of the total structural units included in the linear polymer being 0.01-0.7.
Provided is a lens solution that has excellent lipid detergency, that exhibits high hydrophilization performance, and that exhibits an excellent lipid adhesion prevention effect and a lubricity-imparting effect when used to coat a lens. The lens solution contains a polymer that comprises 2.5-95 mass% of the repeating unit (A) that is indicated below and 2.5-95 mass% of the repeating unit (B) that is indicated below. (A) is a hydrophilic repeating unit. (B) is a repeating unit that comprises a polyoxyalkylene group on a side chain thereof and in which the end of said side chain is configured from an alkyl group having 5-30 carbon atoms, an alkanoyl group having 5-30 carbon atoms, or an aryl group.
A61L 12/14 - Organic compounds not covered by groups or
C08L 51/08 - Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bondsCompositions of derivatives of such polymers grafted on to macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
C09D 151/08 - Coating compositions based on graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bondsCoating compositions based on derivatives of such polymers grafted on to macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
Provided is a lens solution that has excellent lipid detergency, that exhibits high hydrophilization performance, and that exhibits an excellent lipid adhesion prevention effect and a lubricity-imparting effect when used to coat a lens. The lens solution contains a polymer that comprises 2.5-95 mass% of the repeating unit (A) that is indicated below and 2.5-95 mass% of the repeating unit (B) that is indicated below. (A) is a hydrophilic repeating unit. (B) is a repeating unit that comprises a polyoxyalkylene group on a side chain thereof and in which the end of said side chain is configured from an alkyl group having 5-30 carbon atoms, an alkanoyl group having 5-30 carbon atoms, or an aryl group.
Provided are: a solid-phase carrier that has extremely low non-specific adsorption of biological substances such as proteins, peptides, nucleic acids and cells, and is capable of maintaining the activity of bound ligands at a high level; and a method for capturing a target substance using said solid-phase carrier. The method for capturing a target substance is characterized by comprising: a step for preparing a solid-phase carrier for capturing a target substance, said carrier having a base material, at least a portion of the surface thereof being formed of or coated with saccharides, and having a linker of 5-100 atoms having a reactive functional group for binding ligands that specifically bind to the target substance, wherein the saccharides are chemically bound to the linker; a step for binding the ligands to the solid-phase carrier to obtain a solid-phase carrier having ligands bound thereto; and a step for bringing the solid-phase carrier having the ligands bound thereto into contact with a sample containing the target substance that specifically bind to the ligands.
SOLID-PHASE SUPPORT, METHOD FOR PRODUCING SOLID-PHASE SUPPORT, SUPPORT FOR AFFINITY PURIFICATION, FILLER, CHROMATOGRAPHY COLUMN AND PURIFICATION METHOD
The present invention provides a solid-phase support which has both high hydrophilicity and excellent pressure resistance. The solid-phase support is characterized by containing a resin that has a divalent to tetravalent structure represented by formula (1). (In formula (1), R1 represents an n-valent organic group; each X1 independently represents a divalent group represented by formula (2), or the like; and n represents an integer of 2-4.) (In formula (2), R2 represents a divalent hydrocarbon group having 1-2 carbon atoms; and Y1 represents a thio group, a sulfinyl group, an oxy group or an imino group.)
The present invention relates to a method for measuring soluble GPC3 protein in a sample of interest, said method being characterized by using different two antibodies which respectively bind to different epitopes occurring in an N-terminal region of GPC3 protein.
SOLID-PHASE CARRIER, PRODUCTION METHOD FOR SOLID-PHASE CARRIER, CARRIER FOR AFFINITY REFINING, PRODUCTION METHOD FOR FILLER FOR AFFINITY CHROMATOGRAPHY, FILLER FOR AFFINITY CHROMATOGRAPHY, CHROMATOGRAPHY COLUMN, AND REFINING METHOD
The purpose of the present invention is to provide a solid-phase carrier and a carrier for affinity refining that exhibit high dynamic binding capacity when a ligand is immobilized, have excellent antifouling properties, and are unlikely to have non-specific absorption of impurities. The solid-phase carrier has a functional group capable of fixing ligands and is characterized by having a group having: a sulfinyl group, a sulphide group, an oxy group, or an imino group; and a hydroxyl group, a thiol group, an amino group, a carboxy group, a sulfate group, a phosphate group, or an alkanoyl group.
G01N 30/88 - Integrated analysis systems specially adapted therefor, not covered by a single one of groups
59.
SEPARATION METHOD, DETECTION METHOD, SIGNAL MEASUREMENT METHOD, METHOD FOR DETERMINING DISEASE, METHOD FOR EVALUATING DRUG EFFICACY OF DISEASE TREATMENT DRUG, KIT, AND LIQUID COMPOSITION
The purpose of the present invention is to provide a method for separating a vesicle having a lipid bilayer membrane, the method having excellent efficiency of impurity removal, and the method not being prone to rupture a vesicle having a lipid bilayer membrane. A method for separating a vesicle having a lipid bilayer membrane, the method characterized by including a complex-forming step for bringing a biological sample including a vesicle having a lipid bilayer membrane into contact with a solid-phase carrier to which is bound a ligand for recognizing a surface antigen present on a surface of the vesicle and forming a complex of the vesicle and the solid-phase carrier, and a washing step for washing the complex, at least the complex-forming step or the washing step being performed in the presence of a nonionic surfactant.
G01N 33/544 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
The purpose of the present invention is to provide a washing composition with excellent impurity-removing capacity to be used in processes for separating and purifying a target protein. A washing composition to be used in processes for separating and purifying a target protein from a mixed solution containing the target protein and impurities, the washing composition being characterized in containing at least one selected from the following component (A), component (B) and component (C). (A) A cationic surfactant selected from quaternary ammonium salt cationic surfactants having an organic group of at least five carbons and amine salt cationic surfactants having an organic group of at least five carbons (B) A hydroxyl acid ester (C) An amide solvent
SURFACE TREATMENT AGENT FOR SURFACE CONFIGURED FROM INORGANIC MATERIAL, TOOL AND DEVICE HAVING MODIFIED SURFACE, AND METHOD FOR MANUFACTURING TOOL AND DEVICE
To provide a surface treatment agent having excellent peel resistance and excellent effects for suppressing nonspecific adsorption with respect to a surface configured from an inorganic material, a tool and device having a modified surface, and a method for manufacturing the tool and device. A surface treatment agent for a surface configured from an inorganic material, the surface treatment agent including a polymer having the repeating units (A) and (B). (A): A repeating unit including the cationic group represented by formula (1) in a side chain thereof (In formula (1), R1 and R2 are each independently a C1-10 organic group.). (B): A repeating unit including the group represented by formula (2) in a side chain thereof (In formula (2), R3 represents a C2-8 alkanediyl group, R4 represents a hydrogen atom or a C1-40 organic group, and n has a mean value of 1 or greater.).
A61L 27/00 - Materials for prostheses or for coating prostheses
A61L 31/00 - Materials for other surgical articles
C03C 17/32 - Surface treatment of glass, e.g. of devitrified glass, not in the form of fibres or filaments, by coating with organic material with synthetic or natural resins
C08F 220/28 - Esters containing oxygen in addition to the carboxy oxygen containing no aromatic rings in the alcohol moiety
C08F 220/36 - Esters containing nitrogen containing oxygen in addition to the carboxy oxygen
C08F 220/60 - Amides containing nitrogen in addition to the carbonamido nitrogen
C09D 201/02 - Coating compositions based on unspecified macromolecular compounds characterised by the presence of specified groups
G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
patents
