The present invention describes methods and techniques to improve scintigraphic images obtained by using nuclear medicine techniques for diagnostic analysis. The present invention describes a method and technique to up-sample and down-sample nuclear medicine images that models photon counts and noise characteristics of an image at its target resolution.
The present invention describes methods and techniques to improve scintigraphic images obtained by using nuclear medicine techniques for diagnostic analysis. The present invention describes a method and technique to up-sample and down-sample nuclear medicine images that models photon counts and noise characteristics of an image at its target resolution.
The present invention relates to a quality control system for generation of a concordance assessment of medical imaging data from the medical imaging unit, the infusion profile data from the infusion profile data unit, and/or patient characteristic's data using a computer executable algorithm stored in memory. The quality control system comprises a data processing unit, a memory that stores computer executable algorithm, a medical imaging data unit, an infusion profile data unit, and patient characteristic's data. The data processing unit determines a concordance assessment of the data; wherein: a) the concordance assessment is generated by comparing the medical imaging data from the medical imaging unit, the infusion profile data from the infusion profile data unit, and the patient characteristic's data using a computer executable algorithm stored in memory; b) a user warning is generated for excessive mismatches between infusion profile data, imaging data, and/or patient characteristic's data; and c) the infusion profile data unit is Sr-Rb elution system infusion data.
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
4.
Radiopharmaceutical Compositions of Radioactive Halogenated Benzylguandine
The present disclosure concerns radiopharmaceutical compositions of radioactive halogenated benzylguanidine (such as radioiodinated MIBG) or a pharmaceutically acceptable salt, hydrate, or solvate thereof. In a preferred embodiment, the composition has at least 97% of radiochemical purity for at least 4 days. Advantageously, the compositions of the present disclosure may be devoid of parabens, which are carcinogenic and yet are used in known radioactive MIBG compositions. The present disclosure also provides processes of preparing a radioactive halogenated benzylguanidine composition. The compositions of the present disclosure can be used in diagnosis and treatment of various diseases.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Artificial intelligence software for positron emission
tomography (PET) imaging; AI-enabled algorithm for positron
emission tomography (PET) imaging. Software as a service (SaaS) services offering software
utilizing artificial intelligence to assist in performing
pharmacokinetic modelling of positron emission tomography
(PET) imaging and quantifying output results; algorithm
utilizing artificial intelligence to assist in performing
pharmacokinetic modelling of positron emission tomography
(PET) imaging and quantifying output results, such as
myocardial blood flow (MBF).
6.
Radiopharmaceutical delivery system and use thereof for patient infusion
The invention is a theranostic delivery system or radiopharmaceutical drugs delivery system with movable workstation having handles. The workstation of theranostic delivery system or radiopharmaceutical drugs delivery system also has an on-board shielded disposal system for waste collection, which is operated by foot actuated system for locked and unlocked modes during the device journey. The theranostic delivery system or radiopharmaceutical drugs delivery system comprises a status light system that illuminates the working area to enable distance monitoring. Further, the delivery system includes a disposable secondary containment system that protects the core workstation from contamination, a configurable dose transporter and a disposable sealed fluid cartridge to withdraw custom volume from the vial or syringe. The delivery system includes a theranostic informatics management system, which contains a computer screen as a graphical user interface with a retractable rotating arm to receive the various patient infusion parameters.
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Artificial intelligence software for positron emission tomography (PET) imaging; AI-enabled algorithm for positron emission tomography (PET) imaging. Software as a service (SaaS) services offering software utilizing artificial intelligence to assist in performing pharmacokinetic modelling of positron emission tomography (PET) imaging and quantifying output results; algorithm utilizing artificial intelligence to assist in performing pharmacokinetic modelling of positron emission tomography (PET) imaging and quantifying output results, such as myocardial blood flow (MBF).
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) Artificial intelligence software for positron emission tomography (PET) imaging; AI-enabled algorithm for positron emission tomography (PET) imaging (1) Software as a service (SaaS) services offering software utilizing artificial intelligence to assist in performing pharmacokinetic modelling of positron emission tomography (PET) imaging and quantifying output results; algorithm utilizing artificial intelligence to assist in performing pharmacokinetic modelling of positron emission tomography (PET) imaging and quantifying output results, such as myocardial blood flow (MBF)
9.
RADIOPHARMACEUTICAL CONJUGATE COMPOUND FOR DIAGNOSIS AND/OR THERAPEUTIC USES THEREOF
The present invention provides a conjugate compound comprising a nanoparticulated enhanced permeability and retention (EPR) agent, which is an albumin, conjugated with one or more chelating agents, one or more target specific ligands and one or more detectable agents and optionally comprising one or more heterobifunctional crosslinkers and one or more pharmaceutically acceptable therapeutic agents. Further, the present invention provides a radiopharmaceutical composition and a kit comprising the said conjugate and also provides application of the same in diagnosis and therapy of various disease like cancer.
The present invention relates to a theranostic delivery system or radiopharmaceutical drugs delivery system (100) with movable ergonomic workstation (3) having handles on the side(s) to move the cart. The radiopharmaceutical drugs delivery system (100) comprises of simple design and multiple enhanced safety features for user. The delivery system (100) includes a disposable secondary containment system (2) that protect the core workstation from contamination, a configurable dose transporter (6) that allows for safe transport of the hot dose between the hot lab to the infusion site and a disposable sealed fluid cartridge (7) to withdraw custom volume from the vial or syringe. The delivery system (100) comprises a theranostic informatics management system with a computer screen (19) as graphical user interface (GUI) with retractable rotating arm (20) to receive the various patient infusion parameters and effectively manage delivery of desired dose to patient.
A61M 36/06 - Arrangements specially adapted for placing, e.g. inhaling or injecting, radioactive material within the body by fluid injection of radioactive or enhancing agent through a body-piercing conduit
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
11.
Radiopharmaceutical delivery system and use thereof for patient infusion
The invention is a theranostic delivery system or radiopharmaceutical drugs delivery system with movable workstation having handles. The workstation of theranostic delivery system or radiopharmaceutical drugs delivery system also has an on-board shielded disposal system for waste collection, which is operated by foot actuated system for locked and unlocked modes during the device journey. The theranostic delivery system or radiopharmaceutical drugs delivery system comprises a status light system that illuminates the working area to enable distance monitoring. Further, the delivery system includes a disposable secondary containment system that protects the core workstation from contamination, a configurable dose transporter and a disposable sealed fluid cartridge to withdraw custom volume from the vial or syringe. The delivery system includes a theranostic informatics management system, which contains a computer screen as a graphical user interface with a retractable rotating arm to receive the various patient infusion parameters.
G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
12.
RADIOPHARMACEUTICAL CONJUGATE COMPOUND FOR DIAGNOSIS AND/OR THERAPEUTIC USES THEREOF
The present invention provides a conjugate compound comprising a nanoparticulated enhanced permeability and retention (EPR) agent, which is an albumin, conjugated with one or more chelating agents, one or more target specific ligands and one or more detectable agents and optionally comprising one or more heterobifunctional crosslinkers and one or more pharmaceutically acceptable therapeutic agents. Further, the present invention provides a radiopharmaceutical composition and a kit comprising the said conjugate and also provides application of the same in diagnosis and therapy of various disease like cancer.
A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
Disclosed are new configurations of a rubidium elution system that offer several advantages. The rubidium elution systems of the present disclosure comprise an assembly including a 82Sr/82Rb generator, an activity detector, a waste container, a pump, a sensor, a tubing circuit and at least one valve. The waste container is located in the lower section of the assembly. More particularly, the top surface of the waste container compartment is either below the top surface of the generator compartment, or the waste container is at the same elevation than the generator or below the pump.
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes
14.
Container filling system for radioactive materials
Provided are systems for filling containers with radioactive and/or other types of potentially hazardous materials. In some aspects, the systems include a shielding material that substantially defines a chamber and, preferably, substantially blocks radioactivity, a conduit extending from outside to into the chamber, and a unit that is disposed in the chamber proximal to the conduit and is adapted to receive a capsule through the conduit. The systems of the present disclosure can further comprise a syringe, a syringe controller that is disposed in the dispensing chamber and adapted to meter an aliquot from a radioactive stock solution and inject the aliquot into the capsule or a vial.
The present invention provides a radioisotope generator system with enhanced safety features and implements such system. In particular, the present invention provides a radioisotope generator system comprising a surface that comprises three ports: an evacuation port, a loading port, and a saline flush port. The saline flush port is permanently connected with the loading port so that the rinsing solution can be placed on the saline port and pass it through the Mo-99 vial to minimize the wastage of the Mo-99. The present invention provides a robust design of the three-port radioisotope generator, which is cost-effective and ensures improved safety from needle contamination.
G21G 4/08 - Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical applications
G21F 5/015 - Transportable or portable shielded containers for storing radioactive sources, e.g. source carriers for irradiation unitsRadioisotope containers
G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes
16.
EXPERT SCORING SYSTEM FOR MEASUREMENT OF SEVERITY, TREATMENT RESPONSE AND PROGNOSIS OF PERIPHERAL ARTERIAL DISEASE
The present invention provides a method of diagnosing and/or treating a peripheral arterial disease (PAD) via Positron Emitting Tomography (PET) imaging technology. The invention provides artificial intelligence dose calculation, infusion or dose monitoring, image analysis, assessment and providing a severity score based on the image analysis and providing suitable therapy options for the subject diagnosed or at a risk of developing peripheral arterial disease.
A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
G16H 20/17 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
G16H 50/20 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
17.
CLOSED-LOOP ELUTION SYSTEM TO EVALUATE PATIENTS WITH SUSPECTED OR EXISTING PERIPHERAL ARTERIAL DISEASE
The present invention provides a closed loop generation and/or infusion system comprising a radionuclide generator, an activity detector, a controller, a dose calibrator, a pump, eluant source and an automated elution system controlled by software and hardware for generation and infusion of a radionuclide for administering a dose of generated radionuclide into a subject for diagnosing a peripheral arterial disease in a subject suffering from or suspected of suffering from peripheral arterial disease and/or metabolic disease via Positron Emitting Tomography (PET) or Single-photon emission computed tomography (SPECT) imaging technologies. More particularly, the present invention provides methods of determining whether a subject is suffering or at a risk of developing a peripheral arterial disease by performing quantitative assessment of blood flow in lower extremities or limbs of the subject: wherein the quantitative assessment is performed by analyzing one or more images and providing a severity score: and wherein the analysis of the one or more images is performed by using an automated system.
A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
The present invention discloses methods for automatically computing an arterial input function from one or more regions of interest, the method comprising: a. obtaining a plurality of dynamic image data sets comprising volumetric image data from the regions of interest over multiple scanning intervals; b. utilizing an artificial neural network to segment the plurality of dynamic image data sets displaying one or more arterial input function(s) (AIF) in the region(s) of interest; c. automatically estimating, using artificial intelligence, an arterial input function based on plurality of dynamic image data sets combined with one or more time activity curves (TAC) in the region(s) of interest in target organ(s); and d. computing a pre-trained predictive pharmacokinetic AI model arterial input function using time activity curve input associated with region(s) of interest of target organ(s).
A radioisotope elution system is provided that has a component in a cabinet with a door equipped with an authentication system to open. The system may also have a user interface equipped with an authentication system. The radioisotope elution system has a dose calibrator equipped with a lifting mechanism for lifting and/or lowering the vial to be tested in the dose calibrator. The lifting mechanism may be controlled for preventing the vial from being lifted during a quality control test on a sample of eluate in the vial. This feature prevents a user from tampering and/or interfering with the vial while a quality control testing is in progress. There also is provided a radioisotope elution system with a scanning system for entering information about the radioisotope generator and/or the patient in the system. Systems ensuring that the eluant reservoir contains a saline solution are proposed.
A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
G21F 5/015 - Transportable or portable shielded containers for storing radioactive sources, e.g. source carriers for irradiation unitsRadioisotope containers
G21G 4/08 - Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical applications
20.
IMPROVED AND SAFE TECHNIQUES FOR USE OF RADIOACTIVE GENERATOR
The present invention provides a radioisotope elution system for an improved method for the quality control testing of a radioactive generator. In particular, the present invention relates to a radioisotope elution system and its improved method for quality control testing in order to identify and/or extend the shelf-life of the radioactive generator, wherein the said radioisotope elution system is able to produce an increased amount of radioactive eluate by initiating two or more consecutive elutions at an increased flow rate and/or increased volume of the eluant; and wherein the shelf-life of the radioisotope generator is detected by measuring the enhancement of signal-to-noise ratio towards the end of the generator life.
G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes
21.
HEAT RESISTANT GENERATOR COLUMNS FOR ELUTION SYSTEMS
The present disclosure relates in general to nuclear medicine and generators for the production of radiopharmaceuticals for medical use. In particular, present disclosure relates to a generator column that resists high heat such as depyrogenation and sterilization. This allows some steps of the preparation of the column to be performed in a non-sterile environment. This also allows the generator column to be reusable. The present disclosure further describes methods for the preparation of a generator where a parent radioisotope is charged on the column matrix before or after the matrix is loaded in the column.
G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes
G21G 4/08 - Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical applications
22.
IMAGING METHOD FOR DIAGNOSING CARDIOVASCULAR DISEASE
A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
G01R 33/563 - Image enhancement or correction, e.g. subtraction or averaging techniques of moving material, e.g. flow-contrast angiography
The present invention provides an image processing method to assess quantitative myocardial blood flow and/or myocardial flow reserve, comprising the steps of: (a) pre-processing of images comprises: (i) reconstructing dynamic cine 3D tomographic myocardial perfusion imaging (MPI) data, (ii) optionally, denoising to improve the quality of image, (iii) extracting blood input function from a region of interest (ROI) of the left ventricle blood cavity, (iv) estimating the distribution volume (DV), given by the ratio of uptake and washout rates (K1/k2) to stabilize and improve estimation of K1, k2 and total blood volume (TBV) and subsequent myocardial blood flow measures, and (v) data normalization by dividing by the maximum of the blood input function; (b) assessing the individual signals pre-processed in step (a) in order to generate K1 and TBV parametric maps using artificial neural network;
(c) post-processing of K1, k2 and TBV parametric maps; and of rest and stress myocardial blood flow to estimate myocardial flow reserve (MFR) and/or coronary flow reserve (CFR).
Ottawa Heart Institute Research Corporation (Canada)
Inventor
Lefort, Etienne
Teoli, Vicenzo
Dekemp, Robert A.
Klein, Ran
Abstract
Embodiments of the present invention provide for assessing the state of an 82Rb elution system. In certain embodiments, a system begins an assessment that comprises an elution, and a metric may be measured. This metric may be a concentration of 82Rb, 82Sr, or 85Sr in a fluid that is eluted from the generator, the volume of the fluid that is eluted from the generator, or the pressure of the fluid flowing through at least one portion of the system. If the assessment is completed, an output may be generated on a user interface that recommends a course of action, or no course of action, based on a result of the assessment. Should the assessment not complete successfully because it is interrupted, a 82Sr/82Rb generator of the system may be halted so as to prevent a user from performing an end-run around these quality control mechanisms of the 82Rb elution system.
G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes
The present invention relates to a stable pharmaceutical composition of tetrofosmin or pharmaceutically acceptable salts thereof. It also relates to a lyophilized non-radioactive kit which upon reconstitution with 99mTc-pertechnetate solution gives a stable 99mTc-tetrofosmin radiopharmaceutical composition. It also provides process for the preparation of said radiopharmaceutical compositions and their use in diagnostic imaging procedures. The compositions provide desirable technical attributes such as stability, high radiochemical purity (RCP) and desired bio-distribution.
The present invention relates to a medical radioisotope transport system that securely holds the radiopharmaceutical imaging system or medical elution system to the floor of a vehicle and ensures the protection of the elution system during transportation. The transport system as per the present invention includes at least a floor-mounting device, a support mechanism with transportation plates, and a locking device. The transport system as per the present invention is encompassed with advanced technical and safety features to ensure safe transportation of radiopharmaceuticals ensuring compliance to the regulatory and quality requirements. The transport system as per the present invention is easy to use, and successfully overcome all the complexities involved in prior available methods for transportation of radiopharmaceutical imaging systems or medical radioisotope elution systems.
G21F 5/14 - Devices for handling containers or shipping-casks, e.g. transporting devices
G16H 40/40 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes
G21F 5/015 - Transportable or portable shielded containers for storing radioactive sources, e.g. source carriers for irradiation unitsRadioisotope containers
G16H 40/67 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
27.
Elution Protocols and Dosages for Radiopharmaceutical Elution System
A radioisotope elution system is provided. The radioisotope elution system may comprise a controller that is configured to calculate the available amount of daughter radioisotope at any time during establishment of the equilibrium for decay of the parent radioisotope into its daughter radioisotope. The radioisotope elution system may comprise a controller that is configured to schedule various patient infusions planned for the next following days and weeks in accordance with the available amount of daughter radioisotope on each day. The elution system may also comprise a controller that is connected to the imaging software of a radioisotope imaging device, where the radioisotope imaging device is arranged for imaging the patient or a region of the patient; and the controller is configured to start an image acquisition at a predetermined time.
A61M 5/14 - Infusion devices, e.g. infusing by gravityBlood infusionAccessories therefor
G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes
28.
NON-INVASIVE IMAGING METHODS OF DIAGNOSING PERIPHERAL ARTERIAL DISEASE
The present invention provides a method of determining whether a subject is suffering or at a risk of developing a peripheral arterial disease via Positron Emitting Tomography (PET) imaging technology. The method comprises administering a PET radionuclide into the subject via automated generation and/or infusion system, performing PET scan of the region of interest, automated assessment of the PET images, performing assessment and suggesting the most appropriate therapeutic and/or management options for the patients based on the severity score, provides an assessment of regional lower proximity perfusion and perfusion reserve, and/or regional and mean standardized uptake values (SUVs). More particularly, the method of image processing identifies the regional differences in SMP (Skeletal muscle perfusion) and SMPR (Skeletal muscle perfusion reserve) across calf muscles at rest and cuff-induced hyperemia.
The present invention relates to a pharmaceutical cold kit composition comprising a chelating agent linked to somatostatin receptor binding organic moiety, a stabilizer, a buffer, and a caking agent or bulking agent, wherein the composition is free of sequestering agent. Further, the present invention also relates to the process of preparing reconstituted or radiolabeled solution composition having high in use stability and radiochemical purity and use thereof for diagnostic and/or therapeutic purposes.
The present disclosure relates in general to nuclear medicine and generators for the production of radiopharmaceuticals for medical use. In particular, present disclosure relates to a generator column that resists high heat such as depyrogenation and sterilization. This allows some steps of the preparation of the column to be performed in a non-sterile environment. This also allows the generator column to be reusable. The present disclosure further describes methods for the preparation of a generator where a parent radioisotope is charged on the column matrix before or after the matrix is loaded in the column.
G21G 4/06 - Radioactive sources other than neutron sources characterised by constructional features
G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes
The present invention provides a method of determining whether a subject is suffering or at a risk of developing a peripheral arterial disease via Positron Emitting Tomography (PET) imaging technology. The method comprises administering a PET radionuclide into the subject via automated generation and/or infusion system, performing PET scan of the region of interest, automated assessment of the PET images, performing assessment and suggesting the most appropriate therapeutic and/or management options for the patients based on the severity score. The patient can be concurrently suffering from one or more disease like diabetes mellitus.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61K 33/14 - Alkali metal chloridesAlkaline earth metal chlorides
A61M 5/14 - Infusion devices, e.g. infusing by gravityBlood infusionAccessories therefor
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
G05B 19/04 - Programme control other than numerical control, i.e. in sequence controllers or logic controllers
The present invention provides a closed loop generation and/or infusion system comprising a radionuclide generator, an activity detector, a controller, a dose calibrator, a pump, eluant source and an automated elution system controlled by software and hardware for generation and infusion of a radionuclide for administering a dose of generated radionuclide into a subject for diagnosing a peripheral arterial disease in a subject suffering from or suspected of suffering from peripheral arterial disease and/or metabolic disease via Positron Emitting Tomography (PET) or Single-photon emission computed tomography (SPECT) imaging technologies. More particularly, the present invention provides methods of determining whether a subject is suffering or at a risk of developing a peripheral arterial disease by performing quantitative assessment of blood flow in lower extremities or limbs of the subject; wherein the quantitative assessment is performed by analyzing one or more images and providing a severity score; and wherein the analysis of the one or more images is performed by using an automated system.
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A61K 33/14 - Alkali metal chloridesAlkaline earth metal chlorides
A61M 5/14 - Infusion devices, e.g. infusing by gravityBlood infusionAccessories therefor
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
G05B 19/04 - Programme control other than numerical control, i.e. in sequence controllers or logic controllers
viavia Positron Emitting Tomography (PET) imaging technology. The invention provides artificial intelligence dose calculation, infusion or dose monitoring, image analysis, assessment and providing a severity score based on the image analysis and providing suitable therapy options for the subject diagnosed or at a risk of developing peripheral arterial disease.
The present invention provides a method of diagnosing and/or treating a peripheral arterial disease (PAD) via Positron Emitting Tomography (PET) imaging technology. The invention provides artificial intelligence dose calculation, infusion or dose monitoring, image analysis, assessment and providing a severity score based on the image analysis and providing suitable therapy options for the subject diagnosed or at a risk of developing peripheral arterial disease.
viavia Positron Emitting Tomography (PET) or Single-photon emission computed tomography (SPECT) imaging technologies. More particularly, the present invention provides methods of determining whether a subject is suffering or at a risk of developing a peripheral arterial disease by performing quantitative assessment of blood flow in lower extremities or limbs of the subject; wherein the quantitative assessment is performed by analyzing one or more images and providing a severity score; and wherein the analysis of the one or more images is performed by using an automated system.
G05B 19/04 - Programme control other than numerical control, i.e. in sequence controllers or logic controllers
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
38.
NON-INVASIVE IMAGING METHODS OF DIAGNOSING PERIPHERAL ARTERIAL DISEASE
viaviavia automated generation and/or infusion system, performing PET scan of the region of interest, automated assessment of the PET images, performing assessment and suggesting the most appropriate therapeutic and/or management options for the patients based on the severity score. The patient can be concurrently suffering from one or more disease like diabetes mellitus.
G05B 19/04 - Programme control other than numerical control, i.e. in sequence controllers or logic controllers
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Ottawa Heart Institute Research Corporation (Canada)
Inventor
Lefort, Etienne
Teoli, Vincenzo
Dekemp, Robert A.
Klein, Ran
Abstract
Provided are 82Sr/82Rb elution systems that accept patient weight as a input function in order to determine an optimal quantity of radioactive rubidium-82 for delivery to a patient pursuant to an imaging scan. Also disclosed are systems that deliver a saline flush to remove residual 82Rb from the system downstream of the generator, and preferably deliver the removed residual 82Rb to the patient. Other disclosed systems measure the total volume of saline that flows through a 82Sr/82Rb generator, a total volume of saline that flows through the generator and through a bypass line, or a total volume of saline received by a waste reservoir, in order to monitor system components so that optimal system functioning is assured.
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
G16H 20/40 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
The present disclosure concerns radiopharmaceutical compositions of radioactive halogenated benzylguanidine (such as radioiodinated MIBG) or a pharmaceutically acceptable salt, hydrate, or solvate thereof. In a preferred embodiment, the composition has at least 97% of radiochemical purity for at least 4 days. Advantageously, the compositions of the present disclosure may be devoid of parabens, which are carcinogenic and yet are used in known radioactive MIBG compositions. The present disclosure also provides processes of preparing a radioactive halogenated benzylguanidine composition. The compositions of the present disclosure can be used in diagnosis and treatment of various diseases.
41 - Education, entertainment, sporting and cultural services
Goods & Services
Education services, namely, providing training, workshops,
courses, and instruction in the generation, administration,
and storage of radioisotopes for medical diagnostic use.
Elution apparatus for generating, calibrating, dispensing,
and storing radioisotopes for medical diagnostic use, and
parts and fittings therefor; elution apparatus for infusing
and monitoring infusions of radioisotope to patients for
medical diagnostic use; medical equipment, namely, tubing
lines for use in an elution apparatus which generates,
calibrates, dispenses, and stores radioisotopes for medical
diagnostic use.
Elution apparatus for generating, calibrating, dispensing,
and storing radioisotopes for medical diagnostic use, and
parts and fittings therefor; elution apparatus for infusing
and monitoring infusions of radioisotope to patients for
medical diagnostic use; medical equipment, namely, tubing
lines for use in an elution apparatus which generates,
calibrates, dispenses, and stores radioisotopes for medical
diagnostic use.
Elution apparatus for generating, calibrating, dispensing,
and storing radioisotopes for medical diagnostic use, and
parts and fittings therefor; portable generator with
variable radioisotopes and activity for use in an elution
apparatus.
Elution apparatus for generating, calibrating, dispensing,
and storing radioisotopes for medical diagnostic use, and
parts and fittings therefor; elution apparatus for infusing
and monitoring infusions of radioisotope to patients for
medical diagnostic use; medical equipment, namely, tubing
lines for use in an elution apparatus which generates,
calibrates, dispenses, and stores radioisotopes for medical
diagnostic use.
46.
CONTAINER FILLING SYSTEM FOR RADIOACTIVE MATERIALS
Provided are systems for filling containers with radioactive and/or other types of potentially hazardous materials. In some aspects, the systems include a shielding material that substantially defines a chamber and, preferably, substantially blocks radioactivity, a conduit extending from outside to into the chamber, and a unit that is disposed in the chamber proximal to the conduit and is adapted to receive a capsule through the conduit. The systems of the present disclosure can further comprise a syringe, a syringe controller that is disposed in the dispensing chamber and adapted to meter an aliquot from a radioactive stock solution and inject the aliquot into the capsule or a vial.
Provided are systems for filling containers with radioactive and/or other types of potentially hazardous materials. In some aspects, the systems include a shielding material that substantially defines a chamber and, preferably, substantially blocks radioactivity, a conduit extending from outside to into the chamber, and a unit that is disposed in the chamber proximal to the conduit and is adapted to receive a capsule through the conduit. The systems of the present disclosure can further comprise a syringe, a syringe controller that is disposed in the dispensing chamber and adapted to meter an aliquot from a radioactive stock solution and inject the aliquot into the capsule or a vial.
Shielded filling cell for storage, preparation and transferring radioactive iodide solutions to capsules and vials, namely, medical apparatus for the storage, preparation and transferring radioactive iodide solutions to capsules and vials
Elution apparatus for generating, calibrating, dispensing,
and storing radioisotopes for medical diagnostic use, and
parts and fittings therefor; elution apparatus for infusing
and monitoring infusions of radioisotope to patients for
medical diagnostic use.
Elution apparatus for generating, calibrating, dispensing,
and storing radioisotopes for medical diagnostic use, and
parts and fittings therefor; elution apparatus for infusing
and monitoring infusions of radioisotope to patients for
medical diagnostic use; medical equipment, namely, tubing
connectors to link tubing lines for use with an elution
apparatus which apparatus generates, calibrates, dispenses,
and stores radioisotopes for medical diagnostic use.
medical apparatus and instrument for diagnostic use, namely, elution medical apparatus for generating, calibrating, dispensing, and storing radioisotopes, and parts and fittings therefor, for medical diagnostic use; medical apparatus and instrument for diagnostic use, namely, elution apparatus for infusing and monitoring infusions of radioisotope to patients for medical diagnostic use; medical equipment, namely, medical tubing lines for use with an elution apparatus which apparatus generates, calibrates, dispenses, and stores radioisotopes for medical diagnostic use
medical apparatus and instrument for diagnostic use, namely, elution medical apparatus for generating, calibrating, dispensing, and storing radioisotopes, and parts and fittings therefor, for medical diagnostic use; medical apparatus and instrument for diagnostic use, namely, elution apparatus for infusing and monitoring infusions of radioisotope to patients for medical diagnostic use; medical equipment, namely, medical tubing lines for use with an elution apparatus which apparatus generates, calibrates, dispenses, and stores radioisotopes for medical diagnostic use
medical apparatus and instrument for diagnostic use, namely, elution medical apparatus for generating, calibrating, dispensing, and storing radioisotopes, and parts and fittings therefor, for medical diagnostic use; medical apparatus and instrument for diagnostic use, namely, elution apparatus for infusing and monitoring infusions of radioisotope to patients for medical diagnostic use; medical equipment, namely, medical tubing lines for use with an elution apparatus which apparatus generates, calibrates, dispenses, and stores radioisotopes for medical diagnostic use
medical apparatus and instrument for diagnostic use, namely, elution medical apparatus for generating, calibrating, dispensing, and storing radioisotopes, and parts and fittings therefor, for medical diagnostic use; medical apparatus and instrument for diagnostic use, namely, elution apparatus for infusing and monitoring infusions of radioisotope to patients for medical diagnostic use
medical apparatus and instrument for diagnostic use, namely, elution medical apparatus for generating, calibrating, dispensing, and storing radioisotopes, and parts and fittings therefor, for medical diagnostic use; medical apparatus and instrument for diagnostic use, namely, elution apparatus for infusing and monitoring infusions of radioisotope to patients for medical diagnostic use; medical equipment, namely, medical tubing connectors to link tubing lines for use with an elution apparatus which apparatus generates, calibrates, dispenses, and stores radioisotopes for medical diagnostic use
medical apparatus and instrument for diagnostic use, namely, elution medical apparatus for generating, calibrating, dispensing, and storing radioisotopes, and parts and fittings therefor, for medical diagnostic use; portable pulse generator featuring variable radioisotopes and variable radioisotope medical activity for use with the elution apparatus for medical diagnostic use
41 - Education, entertainment, sporting and cultural services
Goods & Services
Education services, namely, providing training, workshops, courses, and instruction in the generation, administration, and storage of radioisotopes for medical diagnostic use
(1) Elution apparatus for generating, calibrating, dispensing, and storing radioisotopes for medical diagnostic use, and parts and fittings therefor; elution apparatus for infusing and monitoring infusions of radioisotope to patients for medical diagnostic use.
41 - Education, entertainment, sporting and cultural services
Goods & Services
(1) Education services, namely, providing training, workshops, courses, and instruction in the generation, calibration, administration, and storage of radioisotopes for medical diagnostic use
(1) Elution apparatus for generating, calibrating, dispensing, and storing radioisotopes for medical diagnostic use, and parts and fittings therefor; elution apparatus for infusing and monitoring infusions of radioisotope to patients for medical diagnostic use; medical equipment, namely, tubing lines for use in an elution apparatus which apparatus generates, calibrates, dispenses, and stores radioisotopes for medical diagnostic use.
(1) Elution apparatus for generating, calibrating, dispensing, and storing radioisotopes for medical diagnostic use, and parts and fittings therefor; elution apparatus for infusing and monitoring infusions of radioisotope to patients for medical diagnostic use; medical equipment, namely, tubing lines for use with an elution apparatus which apparatus generates, calibrates, dispenses, and stores radioisotopes for medical diagnostic use.
(1) Elution apparatus for generating, calibrating, dispensing, and storing radioisotopes for medical diagnostic use, and parts and fittings therefor; elution apparatus for infusing and monitoring infusions of radioisotope to patients for medical diagnostic use; medical equipment, namely, tubing lines for use with an elution apparatus which apparatus generates, calibrates, dispenses, and stores radioisotopes for medical diagnostic use.
(1) Elution apparatus for generating, calibrating, dispensing, and storing radioisotopes for medical diagnostic use, and parts and fittings therefor; elution apparatus for infusing and monitoring infusions of radioisotope to patients for medical diagnostic use; medical equipment, namely, tubing connectors to link tubing lines for use with an elution apparatus which apparatus generates, calibrates, dispenses, and stores radioisotopes for medical diagnostic use.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
(1) Elution apparatus for generating, calibrating, dispensing, and storing radioisotopes for medical diagnostic use, and parts and fittings therefor; generator of radioisotopes for use in an elution apparatus.
Disclosed are new configurations of a rubidium elution system that offer several advantages. The rubidium elution systems of the present disclosure comprise an assembly including a 82Sr/82Rb generator, an activity detector, a waste container, a pump, a sensor, a tubing circuit, at least one valve, where the waste container is located in the lower section of the assembly. More particularly, the top surface of the waste container compartment is either below the top surface of the generator compartment, or the waste container is at the same elevation than the generator or below the pump.
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes
F04B 43/12 - Machines, pumps, or pumping installations having flexible working members having peristaltic action
F04B 17/03 - Pumps characterised by combination with, or adaptation to, specific driving engines or motors driven by electric motors
82Rb generator, an activity detector, a waste container, a pump system, a sensor, a tubing circuit, at least one valve, and a computer; and a dose calibrator outside the primary assembly. The system may have an interface for configuring the dose calibrator, and a locking means for preventing access to the interface and reconfigurations of its parameters. Moreover, the dose calibrator may be in electronic communication with the computer of the system. Furthermore, the electronic communication can be embodied with an electronic cable having a breakaway connector. Also, the dose calibrator may be positioned on a mobile platform.
G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes
Syringe shield for using a syringe that includes a barrel, a tip and a plunger when manipulating a radioactive solution. The syringe shield includes: a shield body in which the syringe is insertable, the shield body having a window; a first flange at a first open end of the syringe shield; a second flange at a second open end of the syringe shield; wherein the second flange, the shield body, and the window include radiation shielding material, and wherein the tip of the syringe is accessible by the second open end of the syringe shield and the plunger extends outside the first open end when the syringe is inserted in the syringe shield.
Syringe shield for using a syringe that includes a barrel, a tip and a plunger when manipulating a radioactive solution. The syringe shield Includes: a shield body In which the syringe is insertable, the shield body having a window; a first flange at a first open end of the syringe shield; a second flange at a second open end of the syringe shield; wherein the second flange, the shield body, and the window include radiation shielding material, and wherein the tip of the syringe is accessible by the second open end of the syringe shield and the plunger extends outside the first open end when the syringe is inserted in the syringe shield.
The present disclosure relates in general to nuclear medicine and generators for the production of radiopharmaceuticals for medical use. In particular, present disclosure relates to a generator column that resists high heat such as depyrogenation and sterilization. This allows some steps of the preparation of the column to be performed in a non-sterile environment. This also allows the generator column to be reusable. The present disclosure further describes methods for the preparation of a generator where a parent radioisotope is charged on the column matrix before or after the matrix is loaded in the column.
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
73.
HEAT RESISTANT GENERATOR COLUMNS FOR ELUTION SYSTEMS
The present disclosure relates in general to nuclear medicine and generators for the production of radiopharmaceuticals for medical use. In particular, present disclosure relates to a generator column that resists high heat such as depyrogenation and sterilization. This allows some steps of the preparation of the column to be performed in a non-sterile environment. This also allows the generator column to be reusable. The present disclosure further describes methods for the preparation of a generator where a parent radioisotope is charged on the column matrix before or after the matrix is loaded in the column.
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
B01D 15/10 - Selective adsorption, e.g. chromatography characterised by constructional or operational features
74.
GENERATOR COLUMNS FOR ELUTION SYSTEMS LOADED WITH PRE-CHARGED MATRIX
The present disclosure relates in general to nuclear medicine and generators for the production of radiopharmaceuticals for medical use. In particular, present disclosure relates to a generator column that resists high heat such as depyrogenation and sterilization. This allows some steps of the preparation of the column to be performed in a non-sterile environment. This also allows the generator column to be reusable. The present disclosure further describes methods for the preparation of a generator where a parent radioisotope is charged on the column matrix before or after the matrix is loaded in the column.
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
75.
Syringe shield assembly for housing and transporting a syringe containing radioactive drug
Syringe shield (2) includes a barrel housing (4), which includes: a barrel housing (6) with a radiation-shielding material, a first open end (8), and a second open end (10); and a removable cover (12) which is slidably connectable to the barrel housing (6). The removable cover (12) includes an end cap (14) which covers the second open end (10) when the removable cover (12) is slidably connected to the barrel housing (6). The barrel housing (4) also includes a plunger housing (16) with a radiation-shielding material. A first end (18) of the plunger housing (16) is open and is connectable to the first open end (8) of the barrel housing (4), and a second end (20) of the plunger housing (16) includes a top cap (22).
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
G21F 5/00 - Transportable or portable shielded containers
The present disclosure relates in general to nuclear medicine and generators for the production of radiopharmaceuticals for medical use. In particular, present disclosure relates to a generator column that resists high heat such as depyrogenation and sterilization. This allows some steps of the preparation of the column to be performed in a non-sterile environment. This also allows the generator column to be reusable. The present disclosure further describes methods for the preparation of a generator where a parent radioisotope is charged on the column matrix before or after the matrix is loaded in the column.
B01D 15/22 - Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
B01D 15/10 - Selective adsorption, e.g. chromatography characterised by constructional or operational features
77.
SYRINGE SHIELD FOR HOUSING AND TRANSPORTING A SYRINGE CONTAINING RADIOACTIVE DRUG
Syringe shield (2) includes a barrel housing (4), which includes: a barrel housing (6) with a radiation shielding material, a first open end (8), and a second open end (10); and a removable cover (12) which is slidably connectable to the barrel housing (6). The removable cover (12) includes an end cap (14) which covers the second open end (10) when the removable cover (12) is slidably connected to the barrel housing (6). The barrel housing (4) also includes a plunger housing (16) with a radiation shielding material. A first end (18) of the plunger housing (16) is open and is connectable to the first open end (8) of the barrel housing (4), and a second end (20) of the plunger housing (16) includes a top cap (22).
A61M 5/32 - NeedlesDetails of needles pertaining to their connection with syringe or hubAccessories for bringing the needle into, or holding the needle on, the bodyDevices for protection of needles
A61M 36/08 - Fluid reservoir shielding, e.g. syringe shielding
78.
Generator columns for elution systems loaded with pre-charged matrix
The present disclosure relates in general to nuclear medicine and generators for the production of radiopharmaceuticals for medical use. In particular, present disclosure relates to a generator column that resists high heat such as depyrogenation and sterilization. This allows some steps of the preparation of the column to be performed in a non-sterile environment. This also allows the generator column to be reusable. The present disclosure further describes methods for the preparation of a generator where a parent radioisotope is charged on the column matrix before or after the matrix is loaded in the column.
G21G 4/06 - Radioactive sources other than neutron sources characterised by constructional features
G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes
G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes
99mTc-tetrofosmin radiopharmaceutical composition. It also provides process for the preparation of said radiopharmaceutical compositions and their use in diagnostic imaging procedures. The compositions provide desirable technical attributes such as stability, high radiochemical purity (RCP) and desired bio-distribution.
Syringe shield for a syringe containing a radioactive solution and infusion pump system for delivering the radioactive solution to a patient. The syringe includes a barrel containing the radioactive solution, a plunger comprising a plunger flange and a plunger stem, and a tip. The syringe shield is made from a radiation-shielding material and includes: a shield body having a first open end and a second open end. The syringe is insertable in the syringe shield such that the plunger is extendable through the first open end and the tip is adjacent the second open end.
A radioisotope elution system is provided. The radioisotope elution system may comprise a controller that is configured to calculate the available amount of daughter radioisotope at any time during establishment of the equilibrium for decay of the parent radioisotope into its daughter radioisotope. The radioisotope elution system may comprise a controller that is configured to schedule various patient infusions planned for the next following days and weeks in accordance with the available amount of daughter radioisotope on each day. The elution system may also comprise a controller that is connected to the imaging software of a radioisotope imaging device, where the radioisotope imaging device is arranged for imaging the patient or a region of the patient; and the controller is configured to start an image acquisition at a predetermined time.
G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
A61M 5/14 - Infusion devices, e.g. infusing by gravityBlood infusionAccessories therefor
A radioisotope elution system is provided, that has at least a component comprised in a cabinet and accessible via a door equipped with an authentication system to ensure safety. The system may also have a user interface equipped with an authentication system. It is also provided a radioisotope elution system that has a dose calibrator equipped with a lifting mechanism for lifting and/or lowering the vial to be tested in the dose calibrator. Advantageously, the lifting mechanism may be controlled for preventing the vial from being lifted during a quality control test on a sample of eluate in the vial. This feature prevents a user from tampering and/or interfering with the vial while a quality control testing is in progress. In another feature, there is provided a radioisotope elution system with a scanning system for entering information about the radioisotope generator and/or the patient in the system. Systems ensuring that the eluant reservoir contains a saline solution are proposed.
A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
G21F 5/015 - Transportable or portable shielded containers for storing radioactive sources, e.g. source carriers for irradiation unitsRadioisotope containers
G21G 4/08 - Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical applications
84.
82RB ELUTION SYSTEM AND DOSE CALIBRATOR CONFIGURATIONS
Disclosed herein are rubidium elution systems comprising a primary assembly including a 82Sr/82Rb generator, an activity detector, a waste container, a pump system, a sensor, a tubing circuit, at least one valve, and a computer; and a dose calibrator outside the primary assembly. The system may have an interface for configuring the dose calibrator, and a locking means for preventing access to the interface and reconfigurations of its parameters. Moreover, the dose calibrator may be in electronic communication with the computer of the system. Furthermore, the electronic communication can be embodied with an electronic cable having a breakaway connector. Also, the dose calibrator may be positioned on a mobile platform.
A61B 50/10 - Furniture specially adapted for surgical or diagnostic appliances or instruments
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
B62B 3/00 - Hand carts having more than one axis carrying transport wheelsSteering devices thereforEquipment therefor
G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes
Disclosed are new configurations of a rubidium elution system that offer several advantages. The rubidium elution systems of the present disclosure comprise an assembly including a 82Sr/82Rb generator, an activity detector, a waste container, a pump, a sensor, a tubing circuit, at least one valve, where the waste container is located in the lower section of the assembly. More particularly, the top surface of the waste container compartment is either below the top surface of the generator compartment, or the waste container is at the same elevation than the generator or below the pump.
A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
A61B 6/58 - Testing, adjusting or calibrating thereof
F04B 23/02 - Pumping installations or systems having reservoirs
F04B 43/12 - Machines, pumps, or pumping installations having flexible working members having peristaltic action
G21G 1/00 - Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation, or particle bombardment, e.g. producing radioactive isotopes
Medical apparatus integrating the medical radioactive drug
generator which dispenses and administers doses of
radioactive rubidium and monitor radioisotopes infusion in
patient; medical apparatus used to precisely administer,
dose and monitor radioisotopes infusion in patient namely,
elution system.
The present disclosure concerns radiopharmaceutical compositions of radioactive halogenated benzylguanidine (such as radioiodinated MIBG) or a pharmaceutically acceptable salt, hydrate, or solvate thereof. In a preferred embodiment, the composition has at least 97% of radiochemical purity for at least 4 days. Advantageously, the compositions of the present disclosure may be devoid of parabens, which are carcinogenic and yet are used in known radioactive MIBG compositions. The present disclosure also provides processes of preparing a radioactive halogenated benzylguanidine composition. The compositions of the present disclosure can be used in diagnosis and treatment of various diseases.
A radioactive drug generator for use in a medical apparatus used to precisely administer, dose, monitor radioisotopes infusion in patients, namely, radioisotope elution system
90.
RADIOPHARMACEUTICAL COMPOSITIONS OF RADIOACTIVE HALOGENATED BENZYLGUANIDINE
The present disclosure concerns radiopharmaceutical compositions of radioactive halogenated benzylguanidine (such as radioiodinated MIBG) or a pharmaceutically acceptable salt, hydrate or solvate thereof. In a preferred embodiment, the compositions have at least 97% of radiochemical purity for at least 4 days. Advantageously, the compositions of the present disclosure are devoid of parabens, which are carcinogenic and yet are used in known radioactive MIBG compositions. The present disclosure also provides processes for preparing a radioactive halogenated benzylguanidine composition. The compositions of the present disclosure can be used in diagnosis and treatment of various diseases.
Medical apparatus which dispenses doses of radioactive
rubidium for diagnostic use; medical device used to
precisely administer, dose and monitor radioisotopes
infusion into patient namely, elution system and supplies
for use with the medical device including connector, IV
line, generator tubing line, saline tubing line, tubing set,
saline solution and radioactive drug generator.
(1) Medical apparatus consisting of a medical radioactive drug generator integrated into the medical device which dispenses and administers doses of radioactive rubidium and monitor radioisotopes infusion in patient; medical apparatus used to precisely administer, dose and monitor radioisotopes infusion in patient namely, elution system.
(1) Medical apparatus consisting of a medical radioactive drug generator integrated into the medical device which, dispenses doses of radioactive rubidium for diagnostic use and administers doses of radioactive rubidium and monitor radioisotopes infusion in patient; medical device used to precisely administer, dose and monitor radioisotopes infusion in patient namely, elution system.
OTTAWA HEART INSTITUTE RESEARCH CORPORATION (Canada)
Inventor
Lefort, Étienne
Teoli, Vincenzo
Dekemp, Robert A.
Klein, Ran
Abstract
Provided are 82Sr/82Rb elution systems that accept patient weight as a input function in order to determine an optimal quantity of radioactive rubidium-82 for delivery to a patient pursuant to an imaging scan. Also disclosed are systems that deliver a saline flush to remove residual 82Rb from the system downstream of the generator, and preferably deliver the removed residual 82Rb to the patient. Other disclosed systems measure the total volume of saline that flows through a 82Sr/82Rb generator, a total volume of saline that flows through the generator and through a bypass line, or a total volume of saline received by a waste reservoir, in order to monitor system components so that optimal system functioning is assured.
A61M 36/06 - Arrangements specially adapted for placing, e.g. inhaling or injecting, radioactive material within the body by fluid injection of radioactive or enhancing agent through a body-piercing conduit
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
OTTAWA HEART INSTITUTE RESEARCH CORPORATION (Canada)
JUBILANT DRAXIMAGE INC. (Canada)
Inventor
Dekemp, Robert A.
Klein, Ran
Lefort, Etienne
Teoli, Vincenzo
Abstract
Provided are 82Sr/82Rb elution systems that accept patient weight as a input function in order to determine an optimal quantity of radioactive rubidium-82 for delivery to a patient pursuant to an imaging scan. Also disclosed are systems that deliver a saline flush to remove residual 82Rb from the system downstream of the generator, and preferably deliver the removed residual 82Rb to the patient. Other disclosed systems measure the total volume of saline that flows through a 82Sr/82Rb generator, a total volume of saline that flows through the generator and through a bypass line, or a total volume of saline received by a waste reservoir, in order to monitor system components so that optimal system functioning is assured.
09 - Scientific and electric apparatus and instruments
16 - Paper, cardboard and goods made from these materials
41 - Education, entertainment, sporting and cultural services
Goods & Services
(1) Online downloadable newsletters and digital advertising, namely, downloadable informational flyers relating to an educational program in the field of thyroid cancer; downloadable webinars intended to healthcare professionals and general public, who have been diagnosed with thyroid cancer, explaining the disease, diagnoses, treatments and follow up
(2) Printed newsletters, informational flyers and brochures relating to an educational program in the field of thyroid cancer (1) Providing online newsletters relating to an educational program in the field of thyroid cancer; Educational services namely, conducting classes, seminars, conferences and workshops intended to healthcare professionals and general public, who have been diagnosed with thyroid cancer, explaining the disease, diagnoses, treatments and follow up; educational services, namely, providing non- downloadable webinars intended to healthcare professionals and general public, who have been diagnosed with thyroid cancer, explaining the disease, diagnoses, treatments and follow up; Providing a website featuring information relating to educational services intended to healthcare professionals and general public, who have been diagnosed with thyroid cancer, explaining the disease, diagnoses, treatments and follow up; Providing online non-downloadable newsletters and websites featuring information relating to an educational program in the field of thyroid cancer
09 - Scientific and electric apparatus and instruments
16 - Paper, cardboard and goods made from these materials
41 - Education, entertainment, sporting and cultural services
Goods & Services
Online downloadable newsletters and digital advertising, namely, downloadable informational flyers relating to an educational program in the field of thyroid cancer; downloadable webinars intended to healthcare professionals and general public, who have been diagnosed with thyroid cancer, explaining the disease, diagnoses, treatments and follow up Printed newsletters, informational flyers and brochures relating to an educational program in the field of thyroid cancer Providing online newsletters relating to an educational program in the field of thyroid cancer; Educational services, namely, conducting classes, seminars, conferences and workshops intended to healthcare professionals and general public, who have been diagnosed with thyroid cancer, explaining the disease, diagnoses, treatments and follow up; educational services, namely, providing non- downloadable webinars intended to healthcare professionals and general public, who have been diagnosed with thyroid cancer, explaining the disease, diagnoses, treatments and follow up; Providing a website featuring information relating to educational services intended to healthcare professionals and general public, who have been diagnosed with thyroid cancer, explaining the disease, diagnoses, treatments and follow up; Providing online non-downloadable newsletters and websites featuring information relating to an educational program in the field of thyroid cancer
09 - Scientific and electric apparatus and instruments
16 - Paper, cardboard and goods made from these materials
41 - Education, entertainment, sporting and cultural services
Goods & Services
Online downloadable newsletters and digital advertising, namely, downloadable informational flyers relating to an educational program in the field of thyroid cancer; downloadable webinars intended to healthcare professionals and general public, who have been diagnosed with thyroid cancer, explaining the disease, diagnoses, treatments and follow up Printed newsletters, informational flyers and brochures relating to an educational program in the field of thyroid cancer Providing online newsletters relating to an educational program in the field of thyroid cancer; Educational services, namely, conducting classes, seminars, conferences and workshops intended to healthcare professionals and general public, who have been diagnosed with thyroid cancer, explaining the disease, diagnoses, treatments and follow up; educational services, namely, providing non- downloadable webinars intended to healthcare professionals and general public, who have been diagnosed with thyroid cancer, explaining the disease, diagnoses, treatments and follow up; Providing a website featuring information relating to educational services intended to healthcare professionals and general public, who have been diagnosed with thyroid cancer, explaining the disease, diagnoses, treatments and follow up; Providing online non-downloadable newsletters and websites featuring information relating to an educational program in the field of thyroid cancer
09 - Scientific and electric apparatus and instruments
16 - Paper, cardboard and goods made from these materials
41 - Education, entertainment, sporting and cultural services
Goods & Services
(1) Online downloadable newsletters and digital advertising, namely, downloadable informational flyers relating to an educational program in the field of thyroid cancer; downloadable webinars intended to healthcare professionals and general public, who have been diagnosed with thyroid cancer, explaining the disease, diagnoses, treatments and follow up
(2) Printed newsletters, informational flyers and brochures relating to an educational program in the field of thyroid cancer (1) Providing online newsletters relating to an educational program in the field of thyroid cancer; Educational services namely, conducting classes, seminars, conferences and workshops intended to healthcare professionals and general public, who have been diagnosed with thyroid cancer, explaining the disease, diagnoses, treatments and follow up; educational services, namely, providing non- downloadable webinars intended to healthcare professionals and general public, who have been diagnosed with thyroid cancer, explaining the disease, diagnoses, treatments and follow up; Providing a website featuring information relating to educational services intended to healthcare professionals and general public, who have been diagnosed with thyroid cancer, explaining the disease, diagnoses, treatments and follow up; Providing online non-downloadable newsletters and websites featuring information relating to an educational program in the field of thyroid cancer
