Abstract

Compositions, systems and methods for multiplex detection of target biomarkers in a simple are provide, offering highly sensitive and multiplexed detection. The compositions and methods are preferably isothermal, label-free, and enzyme-free. The compositions include (i) a DNA carrier molecule comprising (decorated along its length – in a sequence-specific manner) with sequences complementary to sequences in the PNA based anchor and (ii) bifunctional PNA-based anchors which are complementary on the one end to the sequences the analytes of interest and complementary on the other end to sequences on the DNA carrier, the complementarity being provided by a first and a second PNA molecule. The disclosed systems and method include a nanopore sensor.

IPC Classes  ?

• C12Q 1/6816 - Hybridisation assays characterised by the detection means

Abstract

Embodiments of the disclosure relate to semiconductor surface-emitting light sources incorporating random asymmetric cavities. Compared to conventional vertical-cavity surface-emitting lasers (VCSELs), the designs proposed herein generate light that is less coherent, which results in a lower density of coherence artifacts (speckles) in the emitted beam. This is desirable for imaging, display, holographic, and tomographic applications. Embodiments of the disclosure teach different designs that can lower temporal and/or spatial coherence of light by breaking the symmetry of the cavity of the semiconductor light source.

IPC Classes  ?

• H01S 5/183 - Surface-emitting [SE] lasers, e.g. having both horizontal and vertical cavities having only vertical cavities, e.g. vertical cavity surface-emitting lasers [VCSEL]
• H01S 5/187 - Surface-emitting [SE] lasers, e.g. having both horizontal and vertical cavities having only horizontal cavities, e.g. horizontal cavity surface-emitting lasers [HCSEL] using Bragg reflection
• H01S 5/343 - Structure or shape of the active regionMaterials used for the active region comprising quantum well or superlattice structures, e.g. single quantum well [SQW] lasers, multiple quantum well [MQW] lasers or graded index separate confinement heterostructure [GRINSCH] lasers in AIIIBV compounds, e.g. AlGaAs-laser

Abstract

A dislocation-free GaN/InGaN-based nanowires-LED epitaxially grown on a transparent, electrically conductive template substrate. The simultaneous transparency and conductivity are provided by a thin, translucent metal contact integrated with a quartz substrate. The light transmission properties of the translucent metal contact are tunable during epitaxial growth of the nanowires LED. Transparent light emitting diodes (LED) devices, optical circuits, solar cells, touch screen displays, and integrated photonic circuits can be implemented using the current platform.

IPC Classes  ?

• H01L 33/24 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by the semiconductor bodies with a particular shape, e.g. curved or truncated substrate of the light emitting region, e.g. non-planar junction
• H01L 33/00 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof
• H01L 33/06 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by the semiconductor bodies with a quantum effect structure or superlattice, e.g. tunnel junction within the light emitting region, e.g. quantum confinement structure or tunnel barrier
• H01L 33/08 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by the semiconductor bodies with a plurality of light emitting regions, e.g. laterally discontinuous light emitting layer or photoluminescent region integrated within the semiconductor body
• H01L 33/42 - Transparent materials
• H01L 33/40 - Materials therefor
• H01L 33/16 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by the semiconductor bodies with a particular crystal structure or orientation, e.g. polycrystalline, amorphous or porous
• H01L 33/32 - Materials of the light emitting region containing only elements of group III and group V of the periodic system containing nitrogen
• H01L 33/38 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by the electrodes with a particular shape
• H01L 33/62 - Arrangements for conducting electric current to or from the semiconductor body, e.g. leadframe, wire-bond or solder balls
• H01L 33/18 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by the semiconductor bodies with a particular crystal structure or orientation, e.g. polycrystalline, amorphous or porous within the light emitting region
• H01L 33/20 - SEMICONDUCTOR DEVICES NOT COVERED BY CLASS - Details thereof characterised by the semiconductor bodies with a particular shape, e.g. curved or truncated substrate

Abstract

Embodiments include methods of fabricating a zeolite-like metal-organic framework with an ana-topology (ana-ZMOF) thin film membrane, the methods comprising: (1) modifying a substrate with ana-ZMOF crystal precursors in the presence of polyvinylpyrrolidone; and (2) intergrowing the ana-ZMOF crystal precursors in the presence of polyvinylpyrrolidone to form a continuous defect-free thin film of an ana-ZMOF intergrown on the substrate. Embodiments further include methods of separating chemical species comprising contacting an ana-ZMOF thin film membrane with a fluid composition containing one or more chemical species and separating at least one of the chemical species.

IPC Classes  ?

• B01D 69/12 - Composite membranesUltra-thin membranes
• B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• B01D 71/02 - Inorganic material

Abstract

The present invention provides compounds comprising at least one unit of formula (1) or (1′) as well as a process for the preparation of the compounds, intermediates of this process, electronic devices comprising the compounds, and the use of the compounds as semiconducting materials.

IPC Classes  ?

• H10K 85/10 - Organic polymers or oligomers
• C07D 495/22 - Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
• C08G 61/12 - Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
• H10K 10/46 - Field-effect transistors, e.g. organic thin-film transistors [OTFT]

Abstract

A molecular building block composition can include a metal ion component; and a ligand component including a core including at least one functional group associated with the metal ion component and the core.

IPC Classes  ?

• C07D 209/88 - CarbazolesHydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
• B01J 20/22 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising organic material
• B01J 31/16 - Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
• C07C 63/66 - Polycyclic acids with unsaturation outside the aromatic rings
• C07C 65/05 - Compounds having carboxyl groups bound to carbon atoms of six-membered aromatic rings and containing any of the groups OH, O-metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
• C07C 65/11 - Compounds having carboxyl groups bound to carbon atoms of six-membered aromatic rings and containing any of the groups OH, O-metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups polycyclic with carboxyl groups on a condensed ring system containing two rings
• B01J 37/04 - Mixing
• B01J 37/06 - Washing
• C07D 317/36 - Alkylene carbonatesSubstituted alkylene carbonates

Abstract

The present invention relates to a method for protecting surfaces of components against cavitation erosion and components provided with such cavitation protection surfaces, wherein in the surface a plurality of microcavities is provided which entrap gas such as air; the gas, air, entrapped inside the microcavities expands in the vicinity of cavitation bubbles, forming a gas cushion layer that directs cavitation jets away from the surface, thereby protecting the surface against cavitation erosion; the cavitation having a reentrant or double reentrant inlet design with typical T-shape and T-shape profile

IPC Classes  ?

• B63H 1/18 - Propellers with means for diminishing cavitation, e.g. supercavitation
• C23C 14/58 - After-treatment

Abstract

Systems and methods include a number of optical pulses are transmitted by transmitting, by a distributed acoustic sensor (DAS), where the optical pulses are transmitted at an input port associated with a multimode fibers (MMF) used by the DAS, and where the fundamental mode of the MMF is excited. A number of backscattered Rayleigh signals are collected by the DAS. The Rayleigh signals are recorded as an output intensity profile. A position along the MMF that is subject to vibrations and corresponding vibration parameters are determined by analyzing the recorded output intensity profile.

IPC Classes  ?

• G01V 1/20 - Arrangements of receiving elements, e.g. geophone pattern
• G01V 1/22 - Transmitting seismic signals to recording or processing apparatus
• G01H 9/00 - Measuring mechanical vibrations or ultrasonic, sonic or infrasonic waves by using radiation-sensitive means, e.g. optical means
• G01D 5/353 - Mechanical means for transferring the output of a sensing memberMeans for converting the output of a sensing member to another variable where the form or nature of the sensing member does not constrain the means for convertingTransducers not specially adapted for a specific variable using optical means, i.e. using infrared, visible or ultraviolet light with attenuation or whole or partial obturation of beams of light the beams of light being detected by photocells influencing the transmission properties of an optical fibre

Abstract

The present invention provides compounds comprising at least one unit of formula (1) or (1') as well as a process for the preparation of the compounds, intermediates of this process, electronic devices comprising the compounds, and the use of the compounds as semiconducting materials.

IPC Classes  ?

• C07D 495/22 - Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
• C07D 517/22 - Heterocyclic compounds containing in the condensed system at least one hetero ring having selenium, tellurium, or halogen atoms as ring hetero atoms in which the condensed system contains four or more hetero rings
• C08G 61/12 - Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
• H01L 51/00 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof

Abstract

Cell-based phenotypic profiling and image based high-content screening are used to gain insight into the mode of action and potential cellular targets of plants historically used to determine anti-cancer activity of Saudi Arabian plants Juniperus phoenicea (Arar), Anastatica hierochuntica (Kaff Maryam), and Citrullus colocynthis (Hanzal). The cytological profiles of fractions taken from the plants were compared with a set of reference compounds with known modes of action. Cluster analyses of the cytological profiles were performed, which revealed detailed information on the modes of action of the tested compounds as potential topoisomerase inhibitors. Cytological profiles showed that some of these compounds inhibited cell proliferation causing cell cycle disruption.

IPC Classes  ?

• A61K 36/14 - Cupressaceae (Cypress family), e.g. juniper or cypress
• A61K 36/31 - Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
• A61K 36/42 - Cucurbitaceae (Cucumber family)
• A61P 35/00 - Antineoplastic agents

Abstract

Provided in some embodiments is a method of manufacturing a pipe conformable water-cut sensors system. Provided in some embodiments is method for manufacturing a water-cut sensor system that includes providing a helical T-resonator, a helical ground conductor, and a separator at an exterior of a cylindrical pipe. The helical T-resonator including a feed line, and a helical open shunt stub conductively coupled to the feed line. The helical ground conductor including a helical ground plane opposite the helical open shunt stub and a ground ring conductively coupled to the helical ground plane. The feed line overlapping at least a portion of the ground ring, and the separator disposed between the feed line and the portion of the ground ring overlapped by the feed line to electrically isolate the helical T-resonator from the helical ground conductor.

IPC Classes  ?

• G01R 27/26 - Measuring inductance or capacitanceMeasuring quality factor, e.g. by using the resonance methodMeasuring loss factorMeasuring dielectric constants
• G01N 22/04 - Investigating moisture content
• G01N 33/28 - Oils

Abstract

An apparatus for personal health maintenance has a sensor attached at least indirectly to a carrier member in turn attachable to a user or subject and configured for measurement of at least one physiological parameter of the user. A reservoir contains a preselected composition. An electronic processor is operatively connected to the sensor for receiving a signal therefrom encoding a measurement of the physiological parameter, the processor being configured for determining a divergence of the physiological parameter from a predetermined magnitude, the processor being operatively connected to a dispensing mechanism for ejecting, from the reservoir, an amount of the composition to be administered to the user to reduce divergence of the physiological parameter from the predetermined magnitude. The dispensing mechanism includes an expandable polymer composite layer with gas-filled micro-bubbles or microspheres expandable by operation of a heating element.

IPC Classes  ?

• A61B 5/00 - Measuring for diagnostic purposes Identification of persons

Abstract

A method for predicting new edges connecting a network node with a selected set of nodes, and ranking these edges based on a confidence score derived from all non-cyclic paths that connect the end nodes of the edges, is provided. The method is based on the assumption that the more paths connecting two nodes, the more confident a direct link between them would be. A function to calculate the confidence score is provided so that it accounts for the scores from different paths while giving different support for different paths length.

IPC Classes  ?

• H04L 12/24 - Arrangements for maintenance or administration

Abstract

A method for measuring thermal diffusivity/conductivity of a microscale sample includes placing a metallic disk atop the sample, and disposing a nanomembrane over the sample and over the metallic disk so that the nanomembrane, so that the metallic disk, the nanomembrane and the sample are in thermal equilibrium with one another. A laser beam is directed to fall onto the nanomembrane over the sample, while a radiation sensor is operated to detect photoluminescent radiation emitted by the nanomembrane in response to the laser beam. A spectral shift in the detected photoluminescent radiation emitted by the nanomembrane is determined, and thermal diffusivity/conductivity is calculated from the determined spectral shift of the photoluminescence.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• G01N 21/62 - Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
• G01N 25/18 - Investigating or analysing materials by the use of thermal means by investigating thermal conductivity

Abstract

A virtual reality viewer may be integrated with printed materials, such as pamphlets, flyers, magazines, or books. A user may be able to review the printed material regarding the advertised products or services and then activate a virtual reality scene on an electronic display, such as the user's mobile device, that provides the user with more information regarding the products or services. The virtual reality viewer may be attached to pages in the printed materials and constructed in a manner such that the viewer pops up when the pages are opened. The user may place a mobile device in the viewer and/or access an integrated display to view a virtual reality scene related to content in the printed materials.

IPC Classes  ?

• G02B 27/22 - Other optical systems; Other optical apparatus for producing stereoscopic or other three-dimensional effects
• A63H 33/38 - Picture books with additional toy effects, e.g. pop-up or slide displays

Abstract

In one embodiment, the invention provides methods of treatment which use therapeutically effective amounts of Choleste ryl Ester Transfer Protein (CETP) inhibitors to treat a variety of cancers. In certain embodiments, the inhibitor is a CETP-inhibiting small molecule, CETP-inhibiting antisense oligonucleotide, CETP-inhibiting siRNA or a CETP- inhibiting antibody. Related pharmaceutical compositions, kits, diagnostics and screens are also provided.

IPC Classes  ?

• A61K 31/05 - Phenols
• A61K 31/12 - Ketones
• A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
• A61K 39/395 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum
• A61P 35/00 - Antineoplastic agents
• C12N 15/28 - Tumor necrosis factors
• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• G01N 33/535 - Production of labelled immunochemicals with enzyme label
• G01N 33/574 - ImmunoassayBiospecific binding assayMaterials therefor for cancer

Abstract

Embodiments of the present disclosure provide for materials that include conch shell structures, methods of making conch shell slices, devices for storing energy, and the like.

IPC Classes  ?

• H01G 9/07 - Dielectric layers
• H01M 4/04 - Processes of manufacture in general
• H01M 4/36 - Selection of substances as active materials, active masses, active liquids
• H01M 4/58 - Selection of substances as active materials, active masses, active liquids of inorganic compounds other than oxides or hydroxides, e.g. sulfides, selenides, tellurides, halogenides or LiCoFySelection of substances as active materials, active masses, active liquids of polyanionic structures, e.g. phosphates, silicates or borates
• H01G 4/06 - Solid dielectrics

Abstract

Derivatives of plumbagin can be selectively cytotoxic to breast cancer cells. Derivative ‘A’ (Acetyl Plumbagin) has emerged as a lead molecule for testing against estrogen positive breast cancer and has shown low hepatotoxicity as well as overall lower toxicity in nude mice model. The toxicity of derivative ‘A’ was determined to be even lower than vehicle control (ALT and AST markers). The possible mechanism of action identified based on the microarray experiments and pathway mapping shows that derivative ‘A’ could be acting by altering the cholesterol-related mechanisms. The low toxicity profile of derivative ‘A’ highlights its possible role'as future anti-cancer drug and/or as an adjuvant drug to reduce the toxicity of highly toxic chemotherapeutic'drugs.

IPC Classes  ?

• A61K 31/235 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• C07C 69/157 - Acetic acid esters of monohydroxylic compounds of unsaturated alcohols containing six-membered aromatic rings
• A61K 31/05 - Phenols
• A61K 31/122 - Ketones having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
• A61K 31/136 - Amines, e.g. amantadine having aromatic rings, e.g. methadone having the amino group directly attached to the aromatic ring, e.g. benzeneamine
• A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
• A61K 31/222 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
• A61K 31/277 - NitrilesIsonitriles having a ring, e.g. verapamil
• A61K 31/495 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine

Goods & Services

(1) Real estate leasing; leasing of university housing and residential facilities; college consulting services, namely assisting students in applying for scholarships; providing educational scholarships. (2) Licensing of computer software; licensing of intellectual property.

Goods & Services

(1) Real estate leasing, leasing of university housing and residential facilities; college consulting services, namely assisting students in applying for scholarships; providing educational scholarships. (2) Licensing of computer software; licensing of intellectual property.

Goods & Services

(1) Printed matter namely books, directories, catalogues, manuals, diaries, information bulletins, all in printed and electronic format; office supplies namely decals, stickers, desk pads, identification tags; stationery namely memo pads, notebooks, book covers, pens, envelopes, folders, labels, posters, note pads, organizers, paper, postcards; desk accessories namely, posters and banners made of paper, sacks and bags for wrapping and packaging. (1) Educational services namely providing distribution of educational materials in connection therewith, ranging and conducting educational conferences, seminars, workshops; congresses namely for academic research in the field of science, engineering, computer science and information technologies; entertainment services namely arranging academic contests; providing web sites featuring information and links to other web sites regarding university admissions, academic programs, research programs, university housing, university administrative services, university counseling, student activities, university health care services; library services; On line library service; providing on-line university information services; providing on-line items to information concerning universities; on-line bulletin boards;' database management computer services. namely providing community for study, leaning and training; scientific and technological services, research services and design services in the field or biology, chemistry, physics, biosciences, bioengineering, materials science, engineering, applied mathematics, computational science, statistics, marine and ocean research of coral reefs, ocean circulation, fisheries, aquaculture and research related thereto.

Goods & Services

(1) Printed matter namely books, directories, catalogues, manuals, diaries, information bulletins, all in printed and electronic format; office supplies namely decals, stickers, desk pads, identification tags; stationery namely memo pads, notebooks, book covers, pens, envelopes, folders, labels, posters, note pads, organizers, paper, postcards; desk accessories namely, posters and banners made of paper, sacks and bags for wrapping and packaging. (1) Educational services namely providing distribution of educational materials in connection therewith, ranging and conducting educational conferences, seminars, workshops; congresses namely for academic research in the field of science, engineering, computer science and information technologies; entertainment services namely arranging academic contests; providing web sites featuring information and links to other web sites regarding university admissions, academic programs, research programs, university housing, university administrative services, university counseling, student activities, university health care services; library services; On line library service; providing on-line university information services; providing on-line items to information concerning universities; on-line bulletin boards;' database management computer services. namely providing community for study, leaning and training; scientific and technological services, research services and design services in the field or biology, chemistry, physics, biosciences, bioengineering, materials science, engineering, applied mathematics, computational science, statistics, marine and ocean research of coral reefs, ocean circulation, fisheries, aquaculture and research related thereto.