Abstract

Methods for medical diagnosis of heat-related health conditions including heatstroke, compositions comprising RNA or protein biomarkers for heatstroke and heat-associated conditions, probes and primers and antibodies to such biomarkers.

IPC Classes  ?

• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids

Abstract

A microneedle balloon catheter includes a balloon fluidically coupled to a first fluidic channel and microneedles fluidically coupled to a second fluidic channel. The microneedles are on an exterior surface of the balloon. The catheter also includes a guiding sheath. In a first position of the microneedle balloon catheter the balloon, the microneedles, and a portion of the first and second fluidic channels are housed within the guiding sheath. In a second position of the microneedle balloon catheter the balloon and the microneedles are arranged outside of the guiding sheath. The first and second fluidic channels are fluidically isolated from each other.

IPC Classes  ?

• A61M 37/00 - Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
• A61M 25/10 - Balloon catheters

Abstract

A system comprising a stent and a stent delivery device configured with a tiny intravascular ultrasound (“IVUS”) transducer on the tip of a delivery catheter which can image the interior of blood vessels. Methods for treating ostial or bifurcated lesions using the system.

IPC Classes  ?

• A61F 2/958 - Inflatable balloons for placing stents or stent-grafts
• A61F 2/90 - Stents in a form characterised by wire-like elements; Stents in a form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
• A61F 2/97 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve the outer sleeve being splittable
• A61F 2/954 - Instruments specially adapted for placement or removal of stents or stent-grafts for placing stents or stent-grafts in a bifurcation

Abstract

A hybrid ID system for a medical practitioner and patient care includes a hybrid electronic ID/key having a transmitter device having circuitry for storing ID data and transmitting a signal containing the ID data, and a key having a predetermined shape on a surface of the hybrid electronic ID/key. A radio frequency receptor device having circuitry, storing location information, that detects the signal containing ID data, a matching detection section configured to match the predetermined shape of the key, and a movement tracking portion that tracks movement of the predetermined shape as the key is rotated. A computer system including a patient database is configured to receive the ID data in conjunction with the location information from the radio frequency receptor device when the predetermined shape is completely rotated to a final position, and store the ID data, location information, together with patient data associated with the location.

IPC Classes  ?

• G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
• G06K 19/077 - Constructional details, e.g. mounting of circuits in the carrier
• G06K 19/07 - Record carriers with conductive marks, printed circuits or semiconductor circuit elements, e.g. credit or identity cards with integrated circuit chips

Abstract

A device suitable for guiding a trajectory of a surgical shunt or needle comprising two protractors on a curved frame configured to fit over, or attach to, the skull of a patient, wherein the two protractors are respectively oriented in a circular dimension and anterior-posterior/medio-lateral directions. A method for using the device to guide a surgical needle, probe, shunt or other instrument during surgery.

IPC Classes  ?

• A61B 90/11 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis with guides for needles or instruments, e.g. arcuate slides or ball joints
• A61B 17/34 - Trocars; Puncturing needles
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
• A61B 90/10 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis
• A61M 25/06 - Body-piercing guide needles or the like
• A61M 27/00 - Drainage appliances for wounds, or the like

Abstract

A bifunctional expandable stent delivery assembly having a bifunctional expandable stent, a breakable cover, and a balloon. The bifunctional expandable stent has a balloon-expandable body portion and a self-expandable trumpet portion. The breakable cover fits over only the self-expandable trumpet portion and prevents self-expansion. The balloon is used to expand the balloon-expandable portion, which breaks the breakable cover and allows the self-expandable trumpet portion to self-expand. A method of stenting a patient using the bifunctional expandable stent delivery assembly is also provided.

IPC Classes  ?

• A61F 2/954 - Instruments specially adapted for placement or removal of stents or stent-grafts for placing stents or stent-grafts in a bifurcation
• A61F 2/958 - Inflatable balloons for placing stents or stent-grafts
• A61F 2/97 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve the outer sleeve being splittable
• A61L 31/02 - Inorganic materials
• A61F 2/962 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve
• A61F 2/82 - Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents

Abstract

A hybrid ID system for a medical practitioner and patient care includes a hybrid electronic ID/key having a transmitter device having circuitry for storing ID data and transmitting a signal containing the ID data, and a key having a predetermined shape on a surface of the hybrid electronic ID/key. A radio frequency receptor device having circuitry, storing location information, that detects the signal containing ID data, a matching detection section configured to match the predetermined shape of the key, and a movement tracking portion that tracks movement of the predetermined shape as the key is rotated. A computer system including a patient database is configured to receive the ID data in conjunction with the location information from the radio frequency receptor device when the predetermined shape is completely rotated to a final position, and store the ID data, location information, together with patient data associated with the location.

IPC Classes  ?

• G16H 10/60 - ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
• G06K 19/077 - Constructional details, e.g. mounting of circuits in the carrier
• G06K 19/07 - Record carriers with conductive marks, printed circuits or semiconductor circuit elements, e.g. credit or identity cards with integrated circuit chips
• G16H 40/20 - ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms
• G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment

Abstract

A microneedle balloon catheter (100) includes a balloon (104) fluidically coupled to a first fluidic channel (106) and microneedles (110) fluidically coupled to a second fluidic channel (112). The microneedles are on an exterior surface of the balloon. The catheter also includes a guiding sheath (114). In a first position of the microneedle balloon catheter the balloon, the microneedles, and a portion of the first and second fluidic channels are housed within the guiding sheath. In a second position of the microneedle balloon catheter the balloon and the microneedles are arranged outside of the guiding sheath. The first and second fluidic channels are fluidically isolated from each other.

IPC Classes  ?

• A61M 25/10 - Balloon catheters
• A61M 37/00 - Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

A method for applying a regional block of the articular sensory branch of femoral (FN), obturator (ON) and accessory obturator nerves (AON) comprising injection of an anesthetic at a single needle entry point into a these nerves anatomical sites. Another aspect of this technology is a kit for performing this method.

IPC Classes  ?

• A61B 8/08 - Detecting organic movements or changes, e.g. tumours, cysts, swellings
• A61B 8/00 - Diagnosis using ultrasonic, sonic or infrasonic waves
• A61K 31/485 - Morphinan derivatives, e.g. morphine, codeine
• A61P 23/02 - Local anaesthetics

Abstract

A finger protector to prevent lacerations to the fingers of a surgeon during suturing. A kit comprising the finger protector and a method of using it during surgery.

IPC Classes  ?

• A61B 17/04 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for suturing wounds; Holders or packages for needles or suture materials
• A61B 42/20 - Finger-stalls specially adapted for surgery
• A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
• A61L 31/02 - Inorganic materials

Abstract

3/g. The drug carrier is made using a hard mesoporous silica template which is completely removed from the deposited iron oxide. The drug carrier may be loaded with high amounts of hydrophilic anticancer chemotherapeutic drugs and/or hydrophobic hormonal anticancer drugs, and released in a pH-controlled manner inside cancerous cells. Compared to free drugs, the drug microparticle carrier displays enhanced drug accumulation inside tumor tissues, deeply penetrates into a tumor region and kills the tumor cells inside. The designed carriers described here entrap and release different kinds of anticancer drugs in a controlled manner for synergistic combinatorial chemo/hormonal cancer therapy.

IPC Classes  ?

• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 31/138 - Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
• A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin

Abstract

A ethically sound, safe, feasible, and cost-effective microsurgery practice technique that can easily be practiced by trainees having different skill levels and an adjustable device for holding and manipulating vascular tissue during microsurgery practice, especially for practicing anastomoses.

IPC Classes  ?

• A61B 17/11 - Surgical instruments, devices or methods, e.g. tourniquets for closing wounds, or holding wounds closed, e.g. surgical staples; Accessories for use therewith for performing anastomosis; Buttons for anastomosis
• G09B 23/30 - Anatomical models
• B33Y 80/00 - Products made by additive manufacturing
• B33Y 70/00 - Materials specially adapted for additive manufacturing
• B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
• A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
• B33Y 10/00 - Processes of additive manufacturing
• B29K 75/00 - Use of polyureas or polyurethanes as moulding material
• B29L 31/40 - Test specimens
• B33Y 50/00 - Data acquisition or data processing for additive manufacturing
• B29C 64/386 - Data acquisition or data processing for additive manufacturing

Abstract

A system for quickly determining antibiotic sensitivity of a microorganism comprising a triangular-shaped plate and cover for culturing, recovering, and re-suspending recovered microbial colonies and a second triangular-shaped plate comprising a non-liquid medium cut with concentric trenches over which the re-suspended microbial colonies are distributed by centrifugation and contacted with antimicrobial strips or disks.

IPC Classes  ?

• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
• C12Q 1/04 - Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
• C12N 1/02 - Separating microorganisms from their culture media

Abstract

A positioning splint for safely and securely positioning a pediatric patient into a lithotomy position. The splint comprises a toroid, wedge-shaped splint having an anterior and posterior jaw which is attached to shoulder straps or a jacket/vest that holds the splint in place during use. The wedge splint and shoulder attachments are padded. The wedge splint may have a disposable covering. Methods of using the splint to position a patient for urinary catheterization as well as for other procedures, exams and surgeries requiring unobstructed access to the perineal and anorectal areas. Additional wrist/hand and ankle/leg straps are used for conscious patients who are uncooperative or incompetent patients or in the case of a patient with involuntary movement disorders.

IPC Classes  ?

• A61F 5/058 - Splints
• A61F 5/37 - Restraining devices for the body or for body parts; Restraining shirts
• A61F 5/01 - Orthopaedic devices, e.g. long-term immobilising or pressure directing devices for treating broken or deformed bones such as splints, casts or braces

Abstract

Tecoma species. Methods of treating skin lesions (e.g. warts, corns, calluses, and umbilical granulomas) and reducing symptoms associated with the skin lesions using such compositions are specified.

IPC Classes  ?

• A61K 47/20 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
• A61K 36/185 - Magnoliopsida (dicotyledons)
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/06 - Ointments; Bases therefor
• A61P 35/00 - Antineoplastic agents
• A61K 31/19 - Carboxylic acids, e.g. valproic acid
• A61P 17/12 - Keratolytics, e.g. wart or anti-corn preparations
• A61K 31/191 - Acyclic acids having two or more hydroxy groups, e.g. gluconic acid

Abstract

A method for detecting chromosomal abnormalities comprising conversion of a chromosomal image into an ideogram which is compared to a control or standard ideogram of a chromosome; or converting an ideogram of a chromosome into a chromosomal image.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G06T 5/70 - Denoising; Smoothing
• G06T 5/80 - Geometric correction
• G16B 20/20 - Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
• G16B 45/00 - ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks

Abstract

Aggregatibacter actinomycetemcomitans.

IPC Classes  ?

• A61K 35/02 - Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
• A61P 31/04 - Antibacterial agents
• A61P 1/02 - Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• A61K 31/7012 - Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid

Abstract

A steerable endovascular catheter which can be used and for diagnosis and endovascular treatment of vascular diseases. Methods of diagnosis and endovascular treatment comprising steering the catheter through vasculature of a patient.

IPC Classes  ?

• A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters
• A61M 25/09 - Guide wires
• A61M 25/00 - Catheters; Hollow probes
• A61L 29/08 - Materials for coatings
• A61L 29/16 - Biologically active materials, e.g. therapeutic substances
• A61L 29/14 - Materials characterised by their function or physical properties

Abstract

An apparatus and method for testing dissolution properties of a drug, especially anti-inflammatory drugs administered by aerosol into the respiratory system. The apparatus shortens the time it takes for a drug to dissolve and thus provides for rapid testing of new drugs for quality control as well as for regulatory purposes. It is suitable for evaluating bioequivalence or to study the pharmacokinetics of drugs administered into the respiratory system. This method shortens dissolution times for testing a drug to about 10 and 20 minutes and thus provides for rapid testing.

IPC Classes  ?

• G01N 15/02 - Investigating particle size or size distribution
• A61K 9/00 - Medicinal preparations characterised by special physical form
• G09B 23/30 - Anatomical models
• G01N 15/00 - Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials

Abstract

The invention pertains to a medical device: an ECMO (extracorporeal membrane oxygenation) catheter which can be used during right heart and lung failure. It pertains to a dual lumen catheter with a single port of entry which when in place bypasses the right heart and lungs while completing the veno-arterial circuit.

IPC Classes  ?

• A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
• A61M 1/16 - Dialysis systems; Artificial kidneys; Blood oxygenators with membranes
• A61M 25/00 - Catheters; Hollow probes
• A61M 1/26 - Dialysis systems; Artificial kidneys; Blood oxygenators with membranes which are moving

Abstract

A method for isolating a protein complex comprising BCL10 and at least one, preferably all, of ROS1, LSD1, BTK, KU80, KU70, CUL4A, IMP3, thioredoxin, hTID1, DAP3, CDK1/CDC2, PRL1/PTP4A1 or NM23. Methods for using this complex to diagnose or prognose diseases including diabetes, obesity, cancer, neurodegenerative disease or inflammatory diseases associated with activation of NF-κB. Methods for distinguishing lean, obese and diabetic subjects based on expression of BCL10 and its ligands are also disclosed. The invention also pertains to pharmaceutical compositions comprising ligands for BCL10 or other components of this complex or agents such as siRNA or miRNA that regulate the expression of the protein components of this complex.

IPC Classes  ?

• C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
• C07K 14/47 - Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from humans from vertebrates from mammals
• G01N 30/08 - Preparation using an enricher
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
• G01N 30/06 - Preparation

Abstract

Methods of preparing hollow charge transfer co-crystals with reproducible habits and morphology are disclosed. The disclosed methods utilize surfactant to guide the crystal growth in aqueous solutions. The size and shape of the co-crystal can be controlled by the surfactant used, the concentration of the surfactant, and electron donor and electron acceptor, incubation temperature, and mixing condition.

IPC Classes  ?

• C30B 7/14 - Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions the crystallising materials being formed by chemical reactions in the solution
• C09K 11/06 - Luminescent, e.g. electroluminescent, chemiluminescent, materials containing organic luminescent materials
• C30B 29/54 - Organic compounds

Abstract

The invention pertains to a method for temporarily conferring advantageous cancer cell phenotypes, such as a higher proliferation rate, resistance to apoptosis and cell death, and resistance to endogenous factors that inhibit cell growth, on non-cancer cells that help repair and regenerate damaged tissues.

IPC Classes  ?

• A61K 35/13 - Tumour cells, irrespective of tissue of origin
• A61K 35/28 - Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
• A61K 35/44 - Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
• A61K 35/34 - Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
• A61K 9/127 - Liposomes
• A61L 27/38 - Animal cells
• A61K 9/00 - Medicinal preparations characterised by special physical form
• C12N 5/09 - Tumour cells
• A61P 9/00 - Drugs for disorders of the cardiovascular system

Abstract

A blood collection tube for physically separating the plasma and red blood cell fractions of a centrifuged sample is described. The blood collection tube has an elastomeric sleeve with rigid tube segments at both ends. Following blood collection and centrifugation, the elastomeric sleeve may be twisted to constrict its inner diameter and physically separate the two fractions. The blood collection tube may be secured in this position with a pin and a clamp, and further with an adhesive tape with pH paper. This enables blood samples to be transferred over long distances to a central lab facility without spoiling.

IPC Classes  ?

• A61B 5/15 - Devices for taking samples of blood
• B04B 5/04 - Radial chamber apparatus for separating predominantly liquid mixtures, e.g. butyrometers
• A61J 1/20 - Arrangements for transferring fluids, e.g. from vial to syringe

Abstract

The invention is directed to a method for treating a cancer patient by administering an agent that depletes intracellular ATP along with a purine analog, such as fludarabine. It is also directed to a method for selecting a patient having cancer cells susceptible to depletion of their intracellular ATP.

IPC Classes  ?

• A01N 43/04 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atom with one hetero atom
• A61K 31/70 - Carbohydrates; Sugars; Derivatives thereof
• A61K 31/7076 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
• A61P 35/02 - Antineoplastic agents specific for leukemia
• A61K 31/519 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
• A61K 31/137 - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine

Abstract

A peptide that binds to the Si spike protein of Middle East Respiratory syndrome coronavirus or MERS-CoV and a method for inhibiting infection of a subject exposed to or having MERS-CoV by administering the peptide.

IPC Classes  ?

• A61K 38/08 - Peptides having 5 to 11 amino acids
• A61P 31/14 - Antivirals for RNA viruses
• A61K 9/00 - Medicinal preparations characterised by special physical form

Abstract

Compounds, methods of synthesis, and methods of cancer treatment by arylidene-1,3-dioxane-4,6-diones. A Meldrum's acid-based chemistry and hybrid solid-liquid method. The method includes protection of ketone and aldehyde components and simultaneous immobilization on the solid phase, introduction of substituents, grafts and derivatives compatible with the protection, detachment and restoration of active carbonyl reactivity, reaction of ketone library with malonate, reacting of the products with the aldehyde library in liquid phase and separation of the products by preparative HPLC.

IPC Classes  ?

• C07D 239/62 - Barbituric acids
• C07D 319/06 - 1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
• A61P 35/00 - Antineoplastic agents
• C07D 277/34 - Oxygen atoms
• C07D 409/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 417/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 405/06 - Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 407/10 - Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing aromatic rings
• C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

Tecoma plants is specified. A method of treating cancer (e.g. leukemia, lymphoma, breast, colon, and prostate cancer) with the pharmaceutical composition is also provided.

IPC Classes  ?

• C07D 403/14 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
• A61P 35/02 - Antineoplastic agents specific for leukemia

Abstract

Tecoma species. Methods of treating skin lesions (e.g. warts, corns, calluses, and umbilical granulomas) and reducing symptoms associated with the skin lesions using such compositions are specified.

IPC Classes  ?

• A61K 36/185 - Magnoliopsida (dicotyledons)
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/06 - Ointments; Bases therefor
• A61P 35/00 - Antineoplastic agents
• A61K 31/19 - Carboxylic acids, e.g. valproic acid
• A61K 47/20 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
• A61P 17/12 - Keratolytics, e.g. wart or anti-corn preparations
• A61K 31/191 - Acyclic acids having two or more hydroxy groups, e.g. gluconic acid

Abstract

A nanoparticle that has a membrane including a polylactide-block-poly(ethylene glycol)-block-polylactide (PLA-PEG-PLA) and a polyvinyl alcohol, a bovine serum albumin contacting the membrane on the outside of the nanoparticle, a targeting group attached to the outside of the nanoparticle, and a breast cancer therapeutic agent that is encapsulated by the membrane. A nanoparticle that consists of a membrane including a polylactide-block-poly(ethylene glycol)-block-polylactide (PLA-PEG-PLA) and a polyvinyl alcohol, a bovine serum albumin contacting the membrane on the outside of the nanoparticle, breast cancer therapeutic agent that is encapsulated by the membrane, and an anti-Her2 antibody attached to the outer surface of the nanoparticle. A range of a number average molecular weight of the PEG block is 800 Da to 3 kDa and a range of a number average molecular weight of each of the PLA blocks is from 1 kDa to 5 kDa.

IPC Classes  ?

• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
• C07K 16/32 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products from oncogenes
• A61K 31/4196 - 1,2,4-Triazoles
• A61K 9/51 - Nanocapsules

Abstract

A biocompatible curable composition and a method of detecting a border of a tumor, a tissue of interest, or both including injecting the biocompatible curable composition and contacting the border of a tumor or a tissue, the biocompatible curable composition crosslinks to form a three-dimensional cured nanocomposite, and imaging the three-dimensional (3D) cured nanocomposite, and imaging the 3D cured nanocomposite by at least one of MRI, CT, ultrasound, and X-ray, to detect the border of the tumor or the tissue of interest or track tumor motion during radiotherapy treatment. The biocompatible curable composition comprising an organic polymer having a hydrolysable functional group, a metallic nanoparticle, and a polar or a non-polar solvent. A brachytherapy strand consisting of a biocompatible curable composition and a radio-isotope seed. The biocompatible curable composition is shaped into an elongated cylinder and forms a 3D cured nanocomposite with a radio-isotope seed embedded.

IPC Classes  ?

• A61K 49/18 - Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• A61K 49/12 - Macromolecular compounds
• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
• A61K 51/06 - Macromolecular compounds

Abstract

A damping dental post key configured to implant a dental root post for restoration of a tooth is described. The dental post key includes a body for handling and a post carrier having a key shape with respect to a head portion of the dental root post. During implantation of the dental post, rotation of the body compresses a set of springs in contact with the post carrier reducing a reaction force to a tooth root. In this way a limited force will be applied and a root fracture can be prevented. Further, the dental post key can be configured to have a fixed movement in a counterclockwise direction to remove the dental post and a free quarter-cycle movement with effort in a clockwise direction.

IPC Classes  ?

• A61C 13/30 - Fastening of peg-teeth in the mouth; Root pins
• A61C 8/00 - Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools

Abstract

A method is described for exfoliating a microcrystal of an anthracene derivative by irradiation with short pulses of light having a wavelength of 220-420 nm. The irradiation induces a cis-trans isomerization of the anthracene derivative in a part of the microcrystal, which leads to the separation of an outer layer having a thickness of 200-600 nm. The exfoliated microcrystal may be irradiated again with pulses of light of a same or different wavelength.

IPC Classes  ?

• C09B 1/02 - Hydroxy anthraquinones; Ethers or esters thereof
• C07C 68/08 - Purification; Separation; Stabilisation
• A61L 15/62 - Hydrosoluble or hydrodegradable materials

Abstract

A method of regulating body temperature that involves (i) determining, via processing circuitry, if sensor data from a plurality of sensors is in a predetermined normal range, (ii) converting the sensor data to fuzzy values when the sensor data is not in the predetermined normal range, (iii) combining one or more related consequents of the predetermined fuzzy rules, (iv) evaluating the combined consequents to determine a centroid value using a centroid method; and (v) transmitting the centroid value to a thermal management system to activate the thermal management system to a predetermined activation level based on the centroid value, wherein the plurality of sensors include a core temperature sensor, a skin temperature sensor, a skin blood flow sensor, a cardiac output sensor, a neuromuscular activity output sensor, an electromyography sensor, a vibration sensor, and an imaging device.

IPC Classes  ?

• A61F 7/00 - Heating or cooling appliances for medical or therapeutic treatment of the human body
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
• A61B 5/0488 - Electromyography
• A61B 5/029 - Measuring blood output from the heart, e.g. minute volume
• A61B 5/026 - Measuring blood flow
• A61B 5/01 - Measuring temperature of body parts

Abstract

A method is described for exfoliating a microcrystal of an anthracene derivative by irradiation with short pulses of light having a wavelength of 220-420 nm. The irradiation induces a cis-trans isomerization of the anthracene derivative in a part of the microcrystal, which leads to the separation of an outer layer having a thickness of 200-600 nm. The exfoliated microcrystal may be irradiated again with pulses of light of a same or different wavelength.

IPC Classes  ?

• C09B 1/02 - Hydroxy anthraquinones; Ethers or esters thereof
• C07C 68/08 - Purification; Separation; Stabilisation
• A61L 15/62 - Hydrosoluble or hydrodegradable materials

Abstract

A skull-implantable electrode assembly for delivering pulses of electric current to a patient's brain, comprising a conductor housed in an insulated conduit and threaded through an electrically-conductive cannulated skull screw. Details of the exterior construction are discussed, as well as electrode arrangements and methods of treating a medical ailment of a patient.

IPC Classes  ?

• A61N 1/05 - Electrodes for implantation or insertion into the body, e.g. heart electrode
• A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
• A61B 5/0478 - Electrodes specially adapted therefor
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• A61N 1/375 - Constructional arrangements, e.g. casings
• A61N 1/378 - Electrical supply
• A61B 5/04 - Measuring bioelectric signals of the body or parts thereof

Abstract

A nanoparticle that has a membrane including a polylactide-block-poly(ethylene glycol)-block-polylactide (PLA-PEG-PLA) and a polyvinyl alcohol, a bovine serum albumin contacting the membrane on the outside of the nanoparticle, a targeting group attached to the outside of the nanoparticle, and a breast cancer therapeutic agent that is encapsulated by the membrane. A nanoparticle that consists of a membrane including a polylactide-block-poly(ethylene glycol)-block-polylactide (PLA-PEG-PLA) and a polyvinyl alcohol, a bovine serum albumin contacting the membrane on the outside of the nanoparticle, breast cancer therapeutic agent that is encapsulated by the membrane, and an anti-Her2 antibody attached to the outer surface of the nanoparticle. A range of a number average molecular weight of the PEG block is 800 Da to 3 kDa and a range of a number average molecular weight of each of the PLA blocks is from 1 kDa to 5 kDa.

IPC Classes  ?

• A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
• A61K 9/51 - Nanocapsules
• A61K 9/50 - Microcapsules
• A61K 31/4196 - 1,2,4-Triazoles
• C07K 16/32 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products from oncogenes
• A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment

Abstract

A method of treating leukemia in a patient, the method including obtaining a plasma sample from a patient at a first time point and at a second time point, measuring a gene expression level of a set of core clock genes, and at least one of a first set of peripheral clock genes and a second set of peripheral clock genes, each in the plasma sample at the first time point and in the plasma sample at the second time point. Then determining that a first treatment is effective or ineffective for the patient when a correlation of the gene expression level of the set of core clock genes, the first set of peripheral clock genes, and the second set of peripheral clock genes, and treating the patient accordingly.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
• G01N 33/53 - Immunoassay; Biospecific binding assay; Materials therefor
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
• A61K 31/506 - Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 31/498 - Pyrazines or piperazines ortho- or peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
• A61K 31/5025 - Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
• A61K 31/255 - Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
• A61K 31/675 - Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
• A61K 31/7068 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid

Abstract

A skull-implantable magnet assembly for delivering a static magnetic field to a patient's brain, comprising a rod-shaped magnet housed within a skull screw, removably attached to a casing housing at least one flat magnet, is described. Details of the exterior construction are discussed, as well as magnet arrangements and methods of treating a brain tumor or neurological ailment of a patient.

IPC Classes  ?

• A61N 2/06 - Magnetotherapy using magnetic fields produced by permanent magnets
• A61N 2/00 - Magnetotherapy

Abstract

A damping dental post key configured to implant a dental root post for restoration of a tooth is described. The dental post key includes a body for handling and a post carrier having a key shape with respect to a head portion of the dental root post. During implantation of the dental post, rotation of the body compresses a set of springs in contact with the post carrier reducing a reaction force to a tooth root. In this way a limited force will be applied and a root fracture can be prevented. Further, the dental post key can be configured to have a fixed movement in a counterclockwise direction to remove the dental post and a free quarter-cycle movement with effort in a clockwise direction.

IPC Classes  ?

• A61C 13/30 - Fastening of peg-teeth in the mouth; Root pins
• A61C 8/00 - Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools

Abstract

18O-enriched water, and a contrast agent. The biocompatible capsule may be inserted near or inside a tumor under the guidance of X-ray, magnetic resonance, or ultrasonography imaging. Upon proton beam irradiation, the capsule emits positrons, allowing the tumor to be imaged and tracked by a PET detector.

IPC Classes  ?

• A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
• A61N 5/10 - X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
• A61B 6/03 - Computerised tomographs
• G01R 33/48 - NMR imaging systems
• A61K 51/02 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier
• A61K 49/00 - Preparations for testing in vivo
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges
• A61B 8/08 - Detecting organic movements or changes, e.g. tumours, cysts, swellings
• A61B 6/12 - Devices for detecting or locating foreign bodies

Abstract

A biocompatible curable composition and a method of detecting a border of a tumor, a tissue of interest, or both including injecting the biocompatible curable composition and contacting the border of a tumor or a tissue, the biocompatible curable composition crosslinks to form a three-dimensional cured nanocomposite, and imaging the three-dimensional (3D) cured nanocomposite, and imaging the 3D cured nanocomposite by at least one of MRI, CT, ultrasound, and X-ray, to detect the border of the tumor or the tissue of interest or track tumor motion during radiotherapy treatment. The biocompatible curable composition comprising an organic polymer having a hydrolysable functional group, a metallic nanoparticle, and a polar or a non-polar solvent. A brachytherapy strand consisting of a biocompatible curable composition and a radio-isotope seed. The biocompatible curable composition is shaped into an elongated cylinder and forms a 3D cured nanocomposite with a radio-isotope seed embedded.

IPC Classes  ?

• A61K 49/18 - Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• A61K 49/12 - Macromolecular compounds
• A61K 51/06 - Macromolecular compounds
• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes

Abstract

A device for in vivo detecting and quantifying a concentration of an analyte in a peritoneal fluid of a subject. The device includes (a) a catheter having an open proximal end configured to be disposed external to the subject, an open distal end configured to be disposed within the peritoneal cavity comprising the peritoneal fluid, an anchor portion, an outer wall, and an inner wall, (b) a sensor disposed adjacent to the open distal end and configured to detect and quantify the concentration of the analyte in the peritoneal fluid, and (c) a main control unit disposed external to the subject, connected to the sensor via a wire, and configured to control the sensor, receive and store detection and quantification data from the sensor, and transmit the data to a second device. A portion of the wire is disposed between the inner wall and the outer wall of the catheter.

IPC Classes  ?

• A61B 5/05 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
• A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons

Abstract

An apparatus and method are provided for surgical removal of a ring. The apparatus includes guards rotatably connected, handles rotatably connected to the guards that each include a portion partially disposed within the respective guard, a guide connected to the guards, and blades disposed on the portion of the handles. The blades contact with at least one of the guide and an inner surface of the respective guard. A rotational axis of a joint between the guards, a rotational axis of a first handle and a first guard, and a rotational axis of a second handle and a second guard are substantially parallel. Movement of a first end of the first handle toward a first end of the second handle results in movement of a second end of the first handle toward a second end of the second handle, and movement of a first blade toward a second blade.

IPC Classes  ?

• B26B 13/00 - Hand shears; Scissors
• B26B 17/00 - Hand cutting tools with two jaws which come into abutting contact
• B26B 29/06 - Arrangements for guiding hand cutting tools
• B26B 11/00 - Hand knives combined with other implements, e.g. with corkscrew, with scissors, with writing implement

Abstract

An artificial hypothalamus system for regulating body temperature for a human can include monitoring data from a plurality of sensors. The sensor data can be used in a control system to optimize temperature regulation in real time through a feedback loop. The feedback loop can include monitoring the sensor data, evaluating a predetermined set of fuzzy rules using the data, and combining the output of the fuzzy rules to produce a precise value. The precise value can correspond to an output level for various temperature regulation devices, and a signal can be transmitted based on the precise value to activate the temperature regulation devices to a corresponding level of output.

IPC Classes  ?

• A61F 7/00 - Heating or cooling appliances for medical or therapeutic treatment of the human body
• A61B 5/00 - Measuring for diagnostic purposes ; Identification of persons
• A61B 5/01 - Measuring temperature of body parts
• A61B 5/026 - Measuring blood flow
• A61B 5/029 - Measuring blood output from the heart, e.g. minute volume
• A61B 5/0488 - Electromyography
• A61B 5/11 - Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb

Abstract

A therapeutic liposome including a bilayer comprising at least one poly-unsaturated fatty acid (omega-3 fatty acid, omega-6 fatty acid, and omega-9 fatty acid), a beta-glucan, a cholesterol, and a doxorubicin. The liposome has a diameter of 100 nm to 1.5 μm. The beta-glucan and the doxorubicin are encapsulated in the liposome and the cholesterol is integral to the bilayer of the liposome.

IPC Classes  ?

• A61K 9/127 - Liposomes
• A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin

Abstract

Size-controlled ultra-small iron-based metal oxide nanoparticles, nanocolloids comprising the nanoparticles, and methods of making the nanoparticles. The method for making the iron-based nanoparticles include sequential mixing of an iron(III) salt, a metal (II) salt, a carboxylic acid, an amine, and an inorganic base in water at temperatures ranging from 25-80° C. Nanoparticles in the size ranging from 2 nm to 10 nm with a narrow size distribution are obtained with the method. The nanoparticles have an iron-based core surrounded by molecules such as a panel of different carboxylates, polycarboxylates, and amines. Depending on the hydrophilicity of the carboxylates used, the functional nanoparticulate colloid can be dispersed in either organic or aqueous solvents. The nanocolloids comprise the nanoparticles in a concentration ranging from 1-10 mg/ml, and are stable for at least several months.

IPC Classes  ?

• H01F 1/44 - Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of magnetic liquids, e.g. ferrofluids
• H01F 1/00 - Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
• B82Y 40/00 - Manufacture or treatment of nanostructures
• B82Y 30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites

Abstract

This disclosure relates to a cartilage prosthetic implant that can be used in orthopedics for a replacement of a damaged cartilage in a joint between opposing bones, for example in the case of osteoarthritis or trauma. The cartilage prosthetic implant described herein can replace the damaged cartilage at the joint without cutting bones of the joint. The cartilage prosthetic implant can maintain or restore a native joint anatomy, allowing for a natural movement at the joint. The cartilage prosthetic implant can be used as a permanent treatment or an intermediate treatment before requiring a total joint replacement. An example of the cartilage prosthetic implant is described for a knee joint replacement and is divided into a proximal implant configured to replace a cartilage at a distal end of a femur bone and a distal implant configured to replace a cartilage on a proximal end of a tibia bone.

IPC Classes  ?

• A61F 2/08 - Muscles; Tendons; Ligaments
• A61F 2/30 - Joints
• A61F 2/38 - Joints for elbows or knees

Abstract

A method for detecting cancer by determining ratios of alternatively spliced Lamin A/C gene mRNAs in tissue samples, especially an increased ratio of Lamin C to Lamin A mRNAs. Therapeutic for subjects having a tumor or cancer characterized by an elevated ratio of Lamin C to Lamin A mRNA or protein.

IPC Classes  ?

• C12Q 1/68 - Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
• C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer

Abstract

This disclosure relates to a cartilage prosthetic implant that can be used in orthopedics for a replacement of a damaged cartilage in a joint between opposing bones, for example in the case of osteoarthritis or trauma. The cartilage prosthetic implant described herein can replace the damaged cartilage at the joint without cutting bones of the joint. The cartilage prosthetic implant can maintain or restore a native joint anatomy, allowing for a natural movement at the joint. The cartilage prosthetic implant can be used as a permanent treatment or an intermediate treatment before requiring a total joint replacement. An example of the cartilage prosthetic implant is described for a knee joint replacement and is divided into a proximal implant configured to replace a cartilage at a distal end of a femur bone and a distal implant configured to replace a cartilage on a proximal end of a tibia bone.

IPC Classes  ?

• A61F 2/30 - Joints

Abstract

The nano-liposomal aminoglycoside-thymoquinone formulations (100) are suitable for administration to a mammal and include an aminoglycoside antibiotic (amikacin, gentamicin, or tobramycin) and thymoquinone (TQ) encapsulated within a liposome. The liposome-encapsulated aminoglycoside-thymoquinone (TQ) formulations (100) can be administered to a subject in need thereof. The liposome-encapsulated aminoglycoside- thymoquinone formulations (100) are prepared by a method, which comprises forming a lipid film from a mixture of phospholipids and cholesterol; mixing the lipid film with methanol containing thymoquinone in molar ratio; evaporating off the methanol from the mixture; adding polysaccharides and/or polyethylene glycol (PEG) in PBS (phosphate-buffered saline) buffer in volume ratio to form a liposomal mixture; sonicating the liposomal mixture for at least five minutes; adding an aminoglycoside antibiotic in molar ratio with the thymoquinone; sonicating the mixture for at least five minutes; lyophilizing the liposomal aminoglycoside- thymoquinone formulation; and storing it at -80 °C until use.

IPC Classes  ?

• A61K 9/127 - Liposomes
• A61K 31/7036 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins

Abstract

The releasable torque device obviates the need for removal of the wire introducer in order to torque or manipulate a vascular or other guide wire and/or catheter in a medical procedure, and further obviates the need to remove the torque device for wire and/or catheter introduction. The device may include a base cylinder and an inflation cylinder defining a variable fluid volume therebetween. As the inflation cylinder is pushed toward the base cylinder, the fluid is forced through a port in the inner wall of the inflation cylinder and between a tubular inner cylinder and an inflatable guide wire grip within the inner cylinder to squeeze the grip onto the guide wire passing axially therethrough. Alternatively, the device only has a central tube and an inflatable guide wire grip therein, using a remotely disposed fluid pump and reservoir supplying fluid to the tube and guide wire grip.

IPC Classes  ?

• A61M 25/09 - Guide wires

Abstract

A medical material delivery device includes a shaft having a lumen that receives a therapeutic agent, and can include a guide having a channel for receiving a medical instrument adapted for positioning in conjunction with a bodily part. An expandable member positioned in conjunction with the guide is adapted for communication with the bodily part and is arranged to burst open when the expandable member is disrupted by a disrupting mechanism to deliver the therapeutic agent to the bodily part. Further embodiments include a medical instrument and an expandable member in conjunction with the medical instrument to burst or leak to deliver a therapeutic agent. The medical material delivery device can include a bodily fluid locator attached with the device, as well as can include a second expandable member to inflate and deflate to localize a bodily part, with a first expandable member bursting to deliver a therapeutic agent.

IPC Classes  ?

• A61B 17/00 - Surgical instruments, devices or methods, e.g. tourniquets
• A61B 17/12 - Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
• A61B 17/70 - Spinal positioners or stabilisers
• A61B 17/88 - Methods or means for implanting or extracting internal fixation devices
• A61M 25/10 - Balloon catheters
• A61M 37/00 - Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Abstract

The thermometer using differential temperature measurements utilizes a pair of adjacent temperature sensors in order to measure the temperature of a common surface over a pre-selected period of time. The thermometer includes a housing and first and second thermistors mounted adjacent one another on the housing. The first and second thermistors are positioned against the surface, which can be a body part (for oral, rectal or axial body temperature measurements) or can be any other desired surface for which a spot check temperature reading is desired. A programmable current source pre-heats the second thermistor to a pre-selected temperature, while the first thermistor is initially at room temperature. A controller inside the housing causes both the first and second thermistors to take instantaneous temperature measurements of the surface at two successive times. The controller linearizes the measurements to predict the temperature of the surface, which is then displayed to the user.

IPC Classes  ?

• G01N 25/00 - Investigating or analysing materials by the use of thermal means
• G01K 3/14 - Thermometers giving results other than momentary value of temperature giving differentiated values in respect of space
• G01K 1/02 - Means for indicating or recording specially adapted for thermometers
• G01K 7/22 - Measuring temperature based on the use of electric or magnetic elements directly sensitive to heat using resistive elements the element being a non-linear resistance, e.g. thermistor
• G01K 7/42 - Circuits effecting compensation of thermal inertia; Circuits for predicting the stationary value of a temperature
• G01K 13/00 - Thermometers specially adapted for specific purposes

Abstract

The pneumatic system for intussusception treatment, i.e., invagination of a segment of the intestine into an adjacent segment, includes a pressurized gas supply connected to a series of filters, valves, regulators, and sensors connected to a rectal insertion tube to introduce gas at moderate pressure into the intestine of the patient. A computerized control and monitoring subsystem is included. The system preferably includes a heating system to warm the gas as desired. The system also preferably includes an exhaust portion to relieve internal intestinal pressure as required or desired. The exhaust portion of the system preferably includes a filter to absorb undesirable fecal odors that accompany the exhausted gas. At least the rectal insertion tube and the odor filter may be separable from the remainder of the system for convenient disposal. An alarm may be provided to alert the doctor or medical professional of conditions other than normal.

IPC Classes  ?

• A61M 31/00 - Devices for introducing or retaining media, e.g. remedies, in cavities of the body
• A61M 13/00 - Insufflators for therapeutic or disinfectant purposes
• A61M 16/10 - Preparation of respiratory gases or vapours