K.l.r.m., LLC

United States of America

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        United States 6
        World 5
Date
2024 3
Before 2021 8
IPC Class
A61K 36/77 - Sapindaceae (Soapberry family), e.g. lychee or soapberry 9
A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA] 8
A61K 36/185 - Magnoliopsida (dicotyledons) 7
A61K 36/9068 - Zingiber, e.g. garden ginger 7
A61K 36/906 - Zingiberaceae (Ginger family) 5
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Status
Pending 2
Registered / In Force 9
Found results for  patents

1.

NUTRACEUTICAL COMPOSITION AND METHOD FOR THE PROTECTION OF HUMAN ARTERIAL ENDOTHELIAL CELLS FROM ENDOTHELIAL CELL DYSFUNCTION

      
Application Number 18800611
Status Pending
Filing Date 2024-08-12
First Publication Date 2024-12-05
Owner K.L.R.M., LLC (USA)
Inventor Rajfer, Jacob

Abstract

A method for protecting human arterial endothelial cells from endothelial cell dysfunction. The method includes administering a pharmaceutically effective amount of a composition over a sufficient period of time to stimulate the endothelial cells themselves to produce NO resulting in the protection of the endothelial cells and the vasculature from endothelial cell dysfunction.

IPC Classes  ?

  • A61K 36/906 - Zingiberaceae (Ginger family)
  • A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
  • A61K 36/77 - Sapindaceae (Soapberry family), e.g. lychee or soapberry
  • A61P 9/00 - Drugs for disorders of the cardiovascular system

2.

NUTRACEUTICAL COMPOSITION AND METHOD FOR THE PROTECTION OF HUMAN ARTERIAL ENDOTHELIAL CELLS FROM ENDOTHELIAL CELL DYSFUNCTION

      
Application Number 18514609
Status Pending
Filing Date 2023-11-20
First Publication Date 2024-06-06
Owner K.L.R.M., LLC (USA)
Inventor Rajfer, Jacob

Abstract

A method for protecting human arterial endothelial cells from endothelial cell dysfunction. The method includes administering a pharmaceutically effective amount of a composition over a sufficient period of time to stimulate NOS and protecting human arterial endothelial cells from endothelial cell dysfunction.

IPC Classes  ?

  • A61K 36/9068 - Zingiber, e.g. garden ginger
  • A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
  • A61K 36/185 - Magnoliopsida (dicotyledons)
  • A61K 36/77 - Sapindaceae (Soapberry family), e.g. lychee or soapberry
  • A61P 9/00 - Drugs for disorders of the cardiovascular system

3.

NUTRACEUTICAL COMPOSITIONS AND METHODS FOR THE PROTECTION OF HUMAN ARTERIAL ENDOTHELIAL CELLS FROM ENDOTHELIAL CELL DYSFUNCTION

      
Application Number US2023080558
Publication Number 2024/112683
Status In Force
Filing Date 2023-11-20
Publication Date 2024-05-30
Owner K.L.R.M., LLC (USA)
Inventor Rajfer, Jacob

Abstract

A method for protecting human arterial endothelial cells from endothelial cell dysfunction. The method includes administering a pharmaceutically effective amount of a composition over a sufficient period of time to stimulate NOS and protecting human arterial endothelial cells from endothelial cell dysfunction.

IPC Classes  ?

  • A61P 9/08 - Vasodilators for multiple indications
  • A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
  • A61K 36/77 - Sapindaceae (Soapberry family), e.g. lychee or soapberry
  • A61K 36/9068 - Zingiber, e.g. garden ginger
  • A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
  • A61P 15/10 - Drugs for genital or sexual disordersContraceptives for impotence

4.

COMPOSITIONS AND METHODS FOR THE TREATMENT OF CONSTIPATION AND OTHER AILMENTS OF THE GASTROINTESTINAL SYSTEM

      
Application Number US2020016870
Publication Number 2020/163519
Status In Force
Filing Date 2020-02-05
Publication Date 2020-08-13
Owner K.L.R.M., LLC (USA)
Inventor Rajfer, Jacob

Abstract

A method for treatment of constipation and other ailments of the gastrointestinal system includes administering a pharmaceutically effective amount of a composition over a sufficient period of time that results in the production of nitric oxide in gastrointestinal cells and ultimately has beneficial results in treating constipation and other ailments of the gastrointestinal system. The composition comprises ginger or a ginger derivative, muira puama, and paullinia cupana that stimulates nitric oxide in gastrointestinal cells to increase NO and improve bowel functioning thereof.

IPC Classes  ?

  • A23G 4/12 - Chewing gum characterised by the composition containing microorganisms or enzymesChewing gum characterised by the composition containing paramedical or dietetical agents, e.g. vitamins
  • A61K 36/185 - Magnoliopsida (dicotyledons)

5.

Compositions and methods for the treatment of orthopedic ailments

      
Application Number 16809759
Grant Number 10792324
Status In Force
Filing Date 2020-03-05
First Publication Date 2020-07-09
Grant Date 2020-10-06
Owner K.L.R.M., LLC (USA)
Inventor
  • Rajfer, Jacob
  • Rajfer, Rebecca

Abstract

Paullinia cupana, and at least one of the group consisting of L-arginine and L-citrulline.

IPC Classes  ?

  • A61K 36/906 - Zingiberaceae (Ginger family)
  • A61K 36/185 - Magnoliopsida (dicotyledons)
  • A61K 36/77 - Sapindaceae (Soapberry family), e.g. lychee or soapberry
  • A61P 19/10 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
  • A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
  • A61K 36/9068 - Zingiber, e.g. garden ginger

6.

Compositions and methods for treating, inhibiting the onset, and slowing the progression of erectile dysfunction including naturally occurring age related erectile dysfunction

      
Application Number 16444906
Grant Number 10973866
Status In Force
Filing Date 2019-06-18
First Publication Date 2019-10-10
Grant Date 2021-04-13
Owner K.L.R.M., LLC (USA)
Inventor
  • Rajfer, Jacob
  • Milchteim, Mauro
  • Katske, Floyd Alexander

Abstract

Fructus aurantil immaturus (FAI). The compositions of the present inventions are administered in a pharmaceutically effective amount to treat erectile dysfunction. Essential ingredients in formulations of the present inventions for treatment of ED and ARED are ginger (or ginger derivative) and L-citrulline or L-arginine. A daily dosage of at least about 250 mg ginger and at least about 400 mg L-citrulline or L-arginine for a sufficient period of time will result in improved IIEF scores in a substantial number of patients.

IPC Classes  ?

7.

Compositions and methods for the treatment of orthopedic ailments

      
Application Number 15719783
Grant Number 10426812
Status In Force
Filing Date 2017-09-29
First Publication Date 2018-04-19
Grant Date 2019-10-01
Owner K.L.R.M., LLC (USA)
Inventor
  • Rajfer, Jacob
  • Rajfer, Rebecca

Abstract

Muira puama, Paullinia cupana, and at least one of the group consisting of L-arginine and L-citrulline.

IPC Classes  ?

  • A61K 36/906 - Zingiberaceae (Ginger family)
  • A61P 19/10 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
  • A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
  • A61K 36/77 - Sapindaceae (Soapberry family), e.g. lychee or soapberry
  • A61K 36/9068 - Zingiber, e.g. garden ginger
  • A61K 36/185 - Magnoliopsida (dicotyledons)

8.

COMPOSITIONS AND METHODS FOR THE TREATMENT OF ORTHOPEDIC AILMENTS

      
Application Number US2017054284
Publication Number 2018/064469
Status In Force
Filing Date 2017-09-29
Publication Date 2018-04-05
Owner K.L.R.M., LLC (USA)
Inventor
  • Rajfer, Jacob
  • Rajfer, Rebecca

Abstract

A composition for enhancing treatment of orthopedic ailments stimulates iNOS and enhances treatment of orthopedic ailments when a pharmaceutically effective amount is administered over a sufficient period of time. The composition comprises ginger, Muira puama, Paullinia cupana, and at least one of the group consisting of L-arginine and L-citrulline.

IPC Classes  ?

  • A61K 36/9068 - Zingiber, e.g. garden ginger
  • A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
  • A61K 36/185 - Magnoliopsida (dicotyledons)
  • A61K 36/77 - Sapindaceae (Soapberry family), e.g. lychee or soapberry

9.

METHODS AND COMPOSITIONS FOR EXTENDING THE EFFICACY OF PHOSPHODIESTERASE INHIBITORS FOR TREATING ERECTILE DYSFUNCTION

      
Application Number US2016020983
Publication Number 2016/141331
Status In Force
Filing Date 2016-03-04
Publication Date 2016-09-09
Owner K.L.R.M., LLC (USA)
Inventor
  • Milchteim, Mauro
  • Katske, Floyd, Alexander
  • Rajfer, Jacob

Abstract

The duration of treatment of erectile dysfunction ("ED") with phosphodiesterase inhibitors can be extended by concomitant administrations of compositions comprising ginger, and a compound that produces L-arginine in vivo. Preferred compositions of the present invention comprise ginger, L-citrulline, Muira Puama and Paullinia cupana. The compositions are administered in a pharmaceutically effective amount for a sufficient period of time to treat or as a prophylaxis against ED or conditions associated with tissue fibrosis.

IPC Classes  ?

  • A61K 36/906 - Zingiberaceae (Ginger family)
  • A61K 36/752 - Citrus, e.g. lime, orange or lemon
  • A61K 36/185 - Magnoliopsida (dicotyledons)
  • A61K 36/77 - Sapindaceae (Soapberry family), e.g. lychee or soapberry
  • A61P 15/10 - Drugs for genital or sexual disordersContraceptives for impotence

10.

Compositions and methods for treating, inhibiting the onset, and slowing the progression of erectile dysfunction including naturally occurring age related erectile dysfunction

      
Application Number 13786117
Grant Number 10406196
Status In Force
Filing Date 2013-03-05
First Publication Date 2014-09-11
Grant Date 2019-09-10
Owner K.L.R.M., LLC (USA)
Inventor
  • Rajfer, Jacob
  • Milchteim, Mauro
  • Katske, Floyd Alexander

Abstract

Paullinia cupana), Muira puama cortex magnoliae officinalis (CMO) and/or fructus aurantil immaturus (FAI). The compositions of the present inventions are administered in a pharmaceutically effective amount to treat erectile dysfunction. Essential ingredients in formulations of the present inventions for treatment of ED and ARED are ginger (or ginger derivative) and L-citrulline or L-arginine. A daily dosage of at least about 250 mg ginger and at least about 400 mg L-citrulline or L-arginine for a sufficient period of time will result in improved IIEF scores in a substantial number of patients.

IPC Classes  ?

  • A61K 36/9068 - Zingiber, e.g. garden ginger
  • A61K 31/198 - Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
  • A61K 36/63 - Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
  • A61K 36/77 - Sapindaceae (Soapberry family), e.g. lychee or soapberry

11.

COMPOSITIONS AND METHODS FOR TREATING ERECTILE DYSFUNCTION

      
Application Number US2011056965
Publication Number 2012/067745
Status In Force
Filing Date 2011-10-19
Publication Date 2012-05-24
Owner K.L.R.M., LLC (USA)
Inventor Rajfer, Jacob

Abstract

Compositions for treating erectile dysfunction ("ED"), including age related erectile dysfunction (ARED), comprise in a preferred embodiment ginger and an amino acid. Preferably the amino acid is L-arginine and/or L-citrulline. Additionally, the compositions may comprise guarana (Paullinia cupana), Muira puama cortex magnoliae officinalis (CMO) and/or fructus aurantil immaturus (FAI). A daily dosage of at least about 250 mg ginger (or ginger derivative) and at least about 400 mg L-citrulline or L-arginine (or a mixture of L- citrulline and L-arginine) for a sufficient period of time (e.g., at least 30 days) will result in improved IIEF scores in a substantial number of patients that are experiencing ED or ARED and/or will result in maintenance of IIEF scores for patients that might otherwise experienced a decrease in IIEF scrores.

IPC Classes  ?

  • A01N 65/00 - Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
  • A61K 36/906 - Zingiberaceae (Ginger family)