The objective of this invention is to provide a feed for farming fish or crustaceans. The invention provides a feed for fish or crustaceans, the feed comprising: at least one kind selected from the group consisting of nucleotides and amino acids; a vegetable protein; and a carotenoid.
A23K 50/80 - Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
A23K 10/30 - Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hayAnimal feeding-stuffs from material of fungal origin, e.g. mushrooms
A simplified, rigorous and accurate method of measuring pH of an analyte solution with extreme precision, which does not cause errors against actual pH through compensating a pH variation by a liquid temperature or a concentration of potassium chloride of an internal liquid in a glass electrode or a reference electrode when pH is measured with respect to various analyte solutions such as a sample solution having a high concentration of salts, a sample solution contaminated with salts and a sample solution having a low concentration of salts.
The objective of the present invention is to provide a simple, high-precision, rigorous and accurate method of measuring the pH of an analyte solution, with which, when measuring the pH of various analyte solutions such as solutions having a high salinity, solutions contaminated with salt, or solutions having a low salinity, the occurrence of errors relative to the true pH is prevented by compensating for changes in pH resulting from the concentration of potassium chloride in an internal solution in a glass electrode or a reference electrode, or resulting from the temperature of the analyte solution. In this method of measuring the pH of an analyte solution, a voltage generated, with respect to an analyte solution (50), between a pair of electrodes (10) and (20) is detected using said electrodes (10) and (20), which have been set in such a way that the potential difference between the electrodes with respect to a solution outside a pH range of 7.2 to 8.2 is 0 mV, where the pair of electrodes comprise a glass electrode (10) enclosing a glass electrode internal solution (12) containing potassium chloride and a glass electrode buffer solution, and a reference electrode (20) enclosing a reference electrode internal solution (22) containing potassium chloride and a reference electrode buffer solution. The pH value of the analyte solution 50 is detected from the voltage, while compensation is performed using the concentration of the potassium chloride in the reference electrode internal solution (22) and the temperature of the analyte solution (50).
G01N 27/26 - Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variablesInvestigating or analysing materials by the use of electric, electrochemical, or magnetic means by using electrolysis or electrophoresis
Antibacterial materials for application to hygienic equipment, etc. are strongly required to have not only water resistance but also resistance to organic solvents including lower alcohols and to have higher performance which makes the antibacterial activity last stably over a long period. It is also desired to create an environmentally friendly material having biodegradability. The composition according to the present invention is characterized by comprising poly-γ-glutamic acid and dequalinium.
Using conventional synthesis methods, when an unsaturated carboxylic acid or a derivative thereof is synthesized from a hydroxycarboxylic acid or a derivative thereof by a dehydration reaction using a catalyst, the yield has been low. Accordingly, an object of the present invention is to provide a catalyst capable of synthesizing unsaturated carboxylic acids or derivatives thereof by a dehydration reaction that produces a high yield. The synthetic catalyst comprises an apatite compound containing an alkali metal in a crystal structure thereof, and the invention further includes methods for synthesizing an unsaturated carboxylic acid and/or a derivative thereof. The methods comprise contacting the aforementioned synthetic catalyst with the hydroxycarboxylic acid and/or a derivative thereof, so as to synthesize the unsaturated carboxylic acid and/or a derivative thereof by a dehydration reaction.
C07C 51/347 - Preparation of carboxylic acids or their salts, halides, or anhydrides by reactions not involving formation of carboxyl groups
B01J 35/00 - Catalysts, in general, characterised by their form or physical properties
B01J 27/18 - PhosphorusCompounds thereof containing oxygen with metals
C07C 67/327 - Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groupsPreparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by hydrogenolysis of functional groups by elimination of functional groups containing oxygen only in singly bound form
B01J 37/10 - Heat treatment in the presence of water, e.g. steam
An imaging system includes: a first lighting device for irradiating an imaging target object with visible light; a second lighting device for irradiating the imaging target object with near-infrared light; and an image sensor for photodetecting visible light caused by the visible light and coming from the imaging target object and fluorescence caused by the near-infrared light and coming from the imaging target object during a predetermined shutter open period every frame of a predetermined period. The image sensor outputs photodetection signals corresponding to photodetection amounts of the visible light and the fluorescence. The imaging system also includes a controller that generates a composite image of a visible image and a fluorescence image based on the photodetection signals, and has a lighting controller that turns on the second lighting device with optical power corresponding to the shutter open period in synchronism with the shutter open period.
G01N 21/359 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using near infrared light
The purpose of the present invention is to provide: an agent for inhibiting the invasion and metastasis of pancreatic cancer cells, the agent being capable of particularly effectively suppressing the invasion and metastasis of pancreatic cancer cells; DNA encoding RNA that is the active ingredient of this agent for inhibiting the invasion and metastasis of pancreatic cancer cells; and a vector including this DNA that can be used to suppress the invasion and metastasis of pancreatic cancer cells. The agent for inhibiting the invasion and metastasis of pancreatic cancer cells according to the present invention is characterized by including RNA (1) having one or more base sequences selected from SEQ ID NOS: 1-92.
A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
A61K 31/713 - Double-stranded nucleic acids or oligonucleotides
A61P 35/04 - Antineoplastic agents specific for metastasis
The purpose of the present invention is to provide a catalyst with which the past problem of low yield when synthesizing an unsaturated carboxylic acid or derivative thereof from a hydroxycarboxylic acid or derivative thereof by a dehydration reaction can be solved, and by which an unsaturated carboxylic acid and/or derivative thereof can be synthesized at high yield; as well as to provide a synthesis method with which an unsaturated carboxylic acid or derivative thereof can be synthesized at high yield. Provided are a synthesis catalyst for synthesizing an unsaturated carboxylic acid and/or a derivative thereof from a hydroxycarboxylic acid and/or a derivative thereof by a dehydration reaction, wherein the synthesis catalyst for synthesizing an unsaturated carboxylic acid and/or a derivative thereof is characterized by including an apatite compound in which an alkali metal is contained in a crystal structure; and a synthesis method for an unsaturated carboxylic acid and/or a derivative thereof by a dehydration reaction, wherein the synthesis catalyst is brought into contact with a hydroxycarboxylic acid and/or a derivative thereof and a catalyst.
B01J 27/18 - PhosphorusCompounds thereof containing oxygen with metals
C07C 67/327 - Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groupsPreparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by hydrogenolysis of functional groups by elimination of functional groups containing oxygen only in singly bound form
KOCHI ORGANIZATION FOR MEDICAL REFORMATION AND RENEWAL (Japan)
Inventor
Seki Kazuharu
Kitamura Yoritaka
Abe Teruyuki
Sugiura Tetsuro
Miyai Chie
Kusunose Tomoko
Kuramoto Shu
Abstract
An intravenous stand (1) comprises a trolley (4) provided with casters (3), a pole (5) provided upstanding on the trolley (4), and a hook (6) provided on the pole (5) for hanging an intravenous bag. A handle connecting means (11) and a cross bar connecting means (12) are provided on the intravenous stand (1). The handle connecting means is removably connected to left and right handles (2A) of a wheelchair from behind the wheelchair, and the cross bar connecting means is removably connected to a cross bar (13) of the wheelchair from behind the wheelchair. The intravenous stand can be very easily connected to the rear side of the wheelchair. Additionally, the intravenous stand can be connected in a very stable condition to the wheelchair at three points, the three points being the handles (2A) that are positioned on an upper portion of the wheelchair and on the left and right thereof and the cross bar (13) that is positioned on a lower portion of the wheelchair.
The purpose of the present invention is to provide an N-glycosyl acid amide amino acid-nucleic acid derivative, which would serve as a stepping stone to the synthesis of a glycoprotein containing an N-binding type sugar chain, and a method for producing the same. The N-glycosyl acid amide amino acid-nucleic acid derivative according to the present invention or a salt thereof is characterized by being represented by formula (I). In formula (I): R1 to R3 independently represent a hydrogen atom, etc.; R4 represents a hydrogen atom, etc.; B1 and B2 represent a nucleic acid base group; and one of R5 and R6 represents a hydrogen atom and the other represents an N-glycosyl acid amide amino acid group.
C07H 21/04 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
11.
RADIATION/CHEMOTHERAPY SENSITIZER TO BE USED FOR INTRATUMORAL LOCAL INJECTION AND FOR CONTROLLED RELEASE OF HYDROGEN PEROXIDE WITH HYDROGEL AS CARRIER
Provided is a radiation sensitizer or anti-cancer chemotherapy sensitizer which prevents the decomposition of hydrogen peroxide for a longer period of time, and maintains the effect thereof. This radiation sensitizer or anti-cancer chemotherapy sensitizer is characterized by using hydrogen peroxide together with a hydrogel containing a crosslinked gelatin gel.
An HLA-binding peptide binding to a HLA-A type molecule, the HLA-binding peptide includes at least one type of amino acid sequence selected from the group consisting of SEQ ID NOS: 1 to 80, and consists of not less than 8 and not more than 11 amino acid residues. All of these amino acid sequences herein mentioned are the predicted amino acid sequences binding to a human HLA-A type molecule with the prediction program using the certain active learning method.
A61K 38/04 - Peptides having up to 20 amino acids in a fully defined sequenceDerivatives thereof
C07K 7/06 - Linear peptides containing only normal peptide links having 5 to 11 amino acids
C07K 14/47 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans from vertebrates from mammals
The present invention is a foodstuff for cultured fish containing animal products and/or vegetable products as a protein source in which a part or all of the animal products have been replaced with vegetable products, wherein there is provided a foodstuff for cultured fish capable of preventing a decline in growth of the fish and a decline in foodstuff effectiveness, a method for promoting growth of cultured fish using the foodstuff for cultured fish, and a foodstuff additive for preparing the foodstuff for cultured fish. The present invention is a foodstuff for cultured fish containing animal products and/or vegetable products as a protein source in which some or all of the animal products have been replaced with vegetable products, wherein the foodstuff for cultured fish is characterized in containing at least one amino acid selected from the group consisting of alanine, glutamic acid, glutamine, proline, ornithine, citrulline, and arginine.
The purpose of the present invention is to provide: a monomer for the synthesis of RNA, which can be produced with high efficiency and consequently enables the remarkable reduction in the cost for the production of RNA; a method for producing a monomer for the synthesis of RNA in fewer steps with high efficiency; and a method which can synthesize RNA with high efficiency even when a monomer for the synthesis of the RNA is used in an almost stoichiometric amount. The monomer for the synthesis of RNA according to the present invention is characterized by being represented by formula (I) or (I'). [In the formulae, R1 represents a protective group for a hydroxy group; and R2 represents an alkyl group or the like.]
C07H 19/10 - Pyrimidine radicals with the saccharide radical being esterified by phosphoric or polyphosphoric acids
C07H 19/20 - Purine radicals with the saccharide radical being esterified by phosphoric or polyphosphoric acids
C07H 21/02 - Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
15.
HLA-binding peptide, and DNA fragment and recombinant vector coding for said HLA-binding peptide
There is provided an HLA-binding peptide binding to a HLA-A type molecule, the HLA-binding peptide comprising at least one type of amino acid sequence selected from the group consisting of SEQ ID NOS: 1 to 80, and consisting of not less than 8 and not more than 11 amino acid residues. All of these amino acid sequences herein mentioned are the predicted amino acid sequences binding to a human HLA-A type molecule with the prediction program using the certain active learning method.
The problem to be solved by the present invention is to provide a highly-efficient transformation technology, specifically, a highly-efficient promoter used for transforming algae, a vector comprising the promoter, and a method for transforming algae by using the vector. The promoter according to the present invention is characterized in comprising a polynucleotide constituting a non-coding region located upstream of a gene encoding a structural protein of a ClorDNA virus, and the like.
The present invention provides a method of producing a sulfide compound semiconductor containing Cu, Zn, Sn and S, in which the method includes a solvothermal step of conducting a solvothermal reaction of Cu, Zn, Sn and S in an organic solvent, and a rod-like crystal of sulfide compound semiconductor containing Cu, Zn, Sn and S.
An appropriate catalyst is found for synthesis of an unsaturated carboxylic acid and/or a derivative thereof using as a raw material compound a hydroxycarboxylic acid and/or a derivative thereof that can easily be synthesized from a polysaccharide such as biomass-derived cellulose, and an efficient method for synthesizing the unsaturated carboxylic acid and/or the derivative thereof is provided. This method is a method for synthesizing an unsaturated carboxylic acid and/or a derivative thereof, wherein an apatite compound is used as a catalyst to synthesize the unsaturated carboxylic acid and/or the derivative thereof from a biomass-derived hydroxycarboxylic acid and/or a derivative thereof by a dehydration reaction.
C07B 35/00 - Reactions without formation or introduction of functional groups containing hetero atoms, involving a change in the type of bonding between two carbon atoms already directly linked
C07C 51/347 - Preparation of carboxylic acids or their salts, halides, or anhydrides by reactions not involving formation of carboxyl groups
A production method for a coated active material that is composed of an active material, and a coating layer of an- oxide that covers the active material includes a preparation step of mixing an active material, an ingredient of an oxide, and water to prepare a mixture, and a hydrothermal treatment step of hydrothermally treating the mixture to form a coating layer.
Japan Agency for Marine-Earth Science and Technology (Japan)
Inventor
Yanagisawa, Kazumichi
Sakaguchi, Arito
Sakaguchi, Hide
Abstract
The purpose of the invention is to provide a method capable of easily mass-producing moderately fine calcite single crystals. The method for producing calcite single crystals according to the present invention is characterized by comprising: a step of producing a raw material liquid mixture by mixing a raw material calcium carbonate into an ammonium nitrate solution which has a pH of 7.0 to 8.0 and a concentration of 2M or more, in a ratio of 4 g/L to 16 g/L; a step of heating the raw material liquid mixture to 125°C or above; and a step of slowly cooling the raw material liquid mixture.
C30B 7/08 - Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions by cooling of the solution
Provided are: a catalyst which is capable of synthesizing a butanol from ethanol with high selectivity; and a method for synthesizing a butanol using the catalyst. A catalyst which contains a halogenated strontium phosphate apatite which is obtained by substituting some or all of the hydroxy groups in a strontium phosphate apatite structure with bromine or iodine; and a method for synthesizing a butanol using the catalyst.
B01J 27/18 - PhosphorusCompounds thereof containing oxygen with metals
C07C 29/32 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions without formation of hydroxy groups
C07C 31/12 - Monohydroxylic acyclic alcohols containing four carbon atoms
Provided is a technique which has an anti-pruritogenic activity and an anti-inflammatory activity at levels equivalent to or higher than those of steroid drugs and is useful as a prophylactic or therapeutic agent for atopic dermatitis. This prophylactic or therapeutic agent for atopic dermatitis contains an extract of leaves of a plant Vernonia Amygdalina with an alcohol and/or water as an active ingredient.
A61K 36/28 - Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
A61K 8/97 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from algae, fungi, lichens or plantsCosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from derivatives thereof
Disclosed is a highly efficient transformation technique. Specifically disclosed are: a highly efficient promoter which is used for the transformation of algae; a vector which comprises the promoter; and a transformation method for algae, which uses the vector. The promoter is characterized by comprising a polynucleotide that constitutes a non-coding region located in the upstream of a gene encoding a structural protein of a Clor DNA virus, or the like.
The present invention is intended to provide a catalyst which is for synthesizing butanol from ethanol at a high selectivity and which comprises strontium phosphate apatite having the Sr/P atomic ratio of 1.5-2.0, and the synthesis method.
C07C 29/32 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions without formation of hydroxy groups
B01J 23/00 - Catalysts comprising metals or metal oxides or hydroxides, not provided for in group
25.
METHOD FOR SYNTHESIZING UNSATURATED CARBOXYLIC ACID AND/OR DERIVATIVE OF SAME
In the disclosed efficient method for synthesizing an unsaturated carboxylic acid and/or a derivative of same, an appropriate catalyst is found for synthesizing the unsaturated carboxylic acid and/or a derivative of same using as a starting material compound a hydroxycarboxylic acid and/or a derivative of same that can be easily synthesized from a polysaccharide such as biomass-derived cellulose. The method for synthesizing the unsaturated carboxylic acid and/or a derivative of same is characterized by synthesizing the unsaturated carboxylic acid and/or a derivative of same by means of a dehydration reaction from the biomass-derived hydroxycarboxylic acid and/or a derivative of same with an apatite compound as a catalyst.
C07C 51/377 - Preparation of carboxylic acids or their salts, halides, or anhydrides by reactions not involving formation of carboxyl groups by splitting-off hydrogen or functional groupsPreparation of carboxylic acids or their salts, halides, or anhydrides by reactions not involving formation of carboxyl groups by hydrogenolysis of functional groups
B01J 27/18 - PhosphorusCompounds thereof containing oxygen with metals
C07C 57/065 - Preparation by splitting-off H—X, X being halogen, OR, or NR2, R being hydrogen or a hydrocarbon group
C07C 67/327 - Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groupsPreparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by hydrogenolysis of functional groups by elimination of functional groups containing oxygen only in singly bound form
Disclosed is a catalyst for synthesizing butanol from ethanol with high selectivity, which comprises strontium phosphate apatite having an atomic ratio of Sr to P (Sr/P) of 1.5 to 2.0. Also disclosed is a synthesis method.
B01J 27/18 - PhosphorusCompounds thereof containing oxygen with metals
C07C 29/34 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions without formation of hydroxy groups by condensation involving hydroxy groups or the mineral ester groups derived therefrom, e.g. Guerbet reaction
C07C 31/12 - Monohydroxylic acyclic alcohols containing four carbon atoms
Provided is a sensitizing detection agent of an oral or intravenous administration type which enables the detection of bladder cancer with a higher sensitivity without causing pain to the patient. A sensitizing detection agent for bladder cancer comprising 5-aminolevulinic acid (ALA), a derivative thereof, or a salt of these is orally or intravenously administered, and a video camera system is inserted via the urethra and a blue light at 380-440 nm is irradiated to observe the red fluorescent part. Further, VLD-M1 is inserted and a blue light at 405 nm is irradiated to observe fluorescence intensity (relative intensity) of the red light part. For oral administration, 20 mg/kg (maximum of 1 g) of ALA is dissolved in 50 mL of a 5% glucose solution prior to the administration.
As a tumor-specific promoter, a polynucleotide is used which comprises the nucleotide sequence depicted in SEQ ID NO:1 or a nucleotide sequence capable of hybridizing to a nucleotide sequence complementary to the nucleotide sequence depicted in SEQ ID NO:1 under stringent conditions and which has a tumor-specific promoter activity.
Disclosed is a transformation technique which is applicable to a wide variety of algae and is highly efficient. Specifically disclosed is a promoter which is characterized by comprising a polynucleotide that constitutes a non-coding region located upstream from a gene encoding a protein involved in the replication of a Cdeb DNA virus, or the like.
Provided is a sensitizing detection agent for oral administration or intravenous administration type by which bladder can be detected at an improved sensitivity without pain sensation in a patient. A sensitizing detection agent for bladder cancer, which comprises 5-aminolevulinic acid (ALA), a derivative thereof or a salt of the same, is orally or intravenously administered. Then, a video camera system is inserted into the urinary tract and a red light site is monitored under irradiation with a blue fluorescent light at 380 to 440 nm. Further, a VLD-M1 is inserted and the fluorescence intensity (relative intensity) at the red light site is observed under irradiation with a blue fluorescent light at 405 nm. In the case of oral administration, 20 mg/kg (up to 1 g) of ALA is dissolved in 50 ml of a 5% glucose solution before administering.
Disclosed is a method for inducing a cytotoxic T-cell, which is characterized by binding a peptide which comprises at least one amino acid sequence selected from the group consisting of the sequences depicted in SEQ ID NOs:1, 2 and 3 and which is composed of 8 to 11 (inclusive) of amino acid residues or a peptide derived from a precursor of the aforementioned peptide to an HLA molecule on the surface of a cell targeted by the cytotoxic T-cell.
A method for storing a biological material is characterized by comprising a simultaneous voltage application step for applying a negative DC voltage and an AC voltage simultaneously to a biological material (O). In the simultaneous voltage application step, a voltage is preferably applied indirectly to the biological material (O) by containing the biological material (O) in a container (1) surrounding at least the periphery of the biological material (O), and laying one outer surface of the container (1) above a voltage application plate (2) onto which a negative DC voltage and an AC voltage are applied in a superimposed manner.
An examination value predicting device, a predicting method, and a predicting program for accurately predicting the quantity of specific substance or presence/absence of a disease. The examination value predicting method comprises a first step (S2) at which electrophoresis waveform data including a mobility and an absorbance corresponding to the mobility and a prediction formula used for predicting the quantity of predetermined substance in a sample or presence/absence of a disease of an organism from which the sample is taken is recorded in a recording unit, a prediction formula which is a regression formula of an explanation variable representing the absorbance corresponding to the mobility of corrected waveform data created by normalizing electrophoresis waveform data on subjects and correcting the electrophoresis waveform data on subjects with respect to the area and an object variable representing the quantity of predetermined substance or presence/absence of a disease concerning the subjects is used, and corrected waveform data is created by normalizing the electrophoresis waveform data recorded in the recording unit and by correcting the electrophoresis waveform data with respect to the area and a second step (S4) at which the absorbance of the corrected waveform data created from the recorded electrophoresis waveform data is substituted for the absorbance corresponding to the mobility which is the explanation variable of the recorded prediction formula and a prediction value of the quantity of predetermined substance is computed.
Disclosed is a method for detecting a wide variety of compounds each interacting with a target molecule located on a cell membrane in a simple manner and at low cost, which can use a living cell without the need of separating a cell membrane or the like from the cell. Also disclosed is a kit for achieving the method. The method for detecting a compound interacting with a molecule located on a cell membrane comprises the steps of: reacting a cell with a compound having a moiety capable of binding selectively to the molecule located on the cell membrane and a radicalization-promoting moiety; further reacting the cell with a compound having a group capable of being radicalized by the radicalization-promoting moiety and a labeling group; and identifying a compound to which the compound radicalized by the radicalization-promoting moiety is bound.
C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms
G01N 21/78 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
It is intended to provide an HLA-binding peptide which is excellent in the ability to bind to an HLA-A type molecule. Namely, an HLA-binding peptide having an ability to bind to an HLA-A type molecule, which contains one or more amino acid sequences selected from the group consisting of SEQ ID NOS:1 to 50 and consists of 8 or more but not more than 11 amino acid residues, is provided. These amino acid sequences are each an amino acid sequence the ability of which to bind to an HLA-A type molecule has been predicted by a prediction program with the use of the active learning technology as shown in Fig. 1.
Disclosed is a novel radiation sensitizer or anti-cancer chemotherapy sensitizer. Specifically disclose is a radiation sensitizer or anti-cancer chemotherapy sensitizer which can relieve the irritation of an affected area caused by hydrogen peroxide, is safe when injected into a human body, and can delay or reduce the degradation of hydrogen peroxide so as to exert a radiation sensitizing effect or an anti-cancer chemotherapy sensitizing effect with efficiency. The radiation sensitizer or anti-cancer chemotherapy sensitizer comprises a combination of (a) hydrogen peroxide and (b) hyaluronic acid or a salt thereof.
A method of inducing cytotoxic T-cell, characterized by including linking, to an HLA molecule on the surface of a cell targeted by cytotoxic T-cell, either a peptide having at least one amino acid sequence selected from the group consisting of SEQ ID NOS: 1 to 13 and comprised of 8 to 11 amino acid residues, or a peptide derived from a precursor thereof.
It is intended to provide an HLA-binding peptide capable of binding to an HLA-A type molecule, containing at least one amino acid sequence selected from the group consisting of SEQ ID NOS: 1 to 52, and composed of 8 or more and 11 or less amino acid residues. These amino acid sequences are amino acid sequences which are predicted to bind to a human HLA-A molecule using a prediction program utilizing an active learning system shown in FIG. 1.
It is intended to provide a process whereby poly--glutamic acid having a high L-glutamic acid content and excellent qualities can be efficiently produced. Namely, a process for producing poly--glutamic acid characterized by comprising using a bacterium belonging to the species Bacillus megaterium.
A device, method, and program for normalizing a mobility without using any marker, a self-organized map, a method and program for detecting a substance by using a normalized mobility, a detection rule creating method, and a data structure are provided. The mobility normalizing method comprises a step of determining warping functions for converting correction object data which is unit time series data into reference waveform data and the DTW distance corresponding to each warping function, a step of determining the minimum value of the DTW distances and the warping function corresponding to the minimum DTW distance, and a step of determining the slope and intercept of a line approximating the determined warping function and correcting the correction object data by using a linear function specified by the slope and intercept.
Disclosed is an HLA-binding peptide which is capable of binding to an HLA-A-type molecule, comprises at least one amino acid sequence selected from the group consisting of the those depicted in SEQ ID NOs:1 to 30, and is composed of 8 to 11 (inclusive) amino acid residues. It is predicted, by using a predicting program utilizing an active leaning task shown in Fig. 1, that all of the amino acid sequences are capable of binding to a human HLA-A molecule.
The present invention provides a method for detecting and judging lipid metabolism disorders and a risk of developing diseases caused thereby, and reagents, such as a probe and primer, for lipid metabolism disorder diagnosis, and a reagent kit comprising at least one of such reagents, all of which can be effectively used in the detection method. The present invention can be accomplished by detecting a genetic polymorphism that causes a change (TRA) of the 94th amino acid of FABP1 (fatty acid binding protein 1, liver [Homo sapience]) in a subject.
patents
