Senna tora (L.) .Fagophyrum esculentum .Sorghum bicolorPhellinus linteusPhellinus linteus extract. The Senna tora (L.) Roxb. extract, the Fagophyrum esculentum MOENCH extract, the Sorghum bicolor extract, and/or the Phellinus linteus extract, according to the present invention, have the effect of restoring hearing function or ameliorating, preventing or treating hearing impairment, and thus can be effectively used as a pharmaceutical composition, a food composition, a health functional food, a quasi-drug composition, and a feed composition.
A23K 10/16 - Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives
A61K 36/899 - Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
A23K 10/30 - Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hayAnimal feeding-stuffs from material of fungal origin, e.g. mushrooms
2.
COMPOSITION FOR STABILIZING BACTERIOPHAGE AND STERILIZATION METHOD USING SAME
The present invention relates to a composition for stabilizing a bacteriophage, a bacteriophage composition comprising same, a food packaging material, and a sterilization method using same. The composition for stabilizing bacteriophage according to the present invention can be commercialized and stored in a more convenient, economical, and efficient manner even at room temperature compared to an existing bacteriophage storage method, and is manufactured into a bacteriophage composition comprising the composition for stabilizing bacteriophage or a packaging material coated with bacteriophage, whereby the composition can be directly applied to food for biological control and thus advantageously used for preventing bacterial contamination of food, maintaining food safety, and the like.
C08L 5/00 - Compositions of polysaccharides or of their derivatives not provided for in group or
B65D 81/28 - Applications of food preservatives, fungicides, pesticides or animal repellants
3.
COMPOSITION FOR ENHANCING IMMUNE FUNCTION OR PREVENTING, AMELIORATING OR TREATING OBESITY OR METABOLIC DISEASE COMPRISING ACORUS GRAMINEUS SOLANDER EXTRACT OR FRACTION THEREOF AS ACTIVE INGREDIENT
The present invention relates to a composition for enhancing immune function or preventing, ameliorating or treating obesity or a metabolic disease, a prebiotic composition or a composition for preventing, ameliorating or treating leaky gut syndrome, comprising an Acorus gramineus Solander extract as an active ingredient. The Acorus gramineus Solander extract and a fraction thereof, of the present invention, have the following effects of: a) very greatly enhancing immune function, and improving immune function through dietary and lifestyle habits of daily life for a long period of time due to no toxicity thereof; b) inhibiting an increase in body weight and body fat, inhibiting an increase in blood glucose, reducing blood insulin concentration and HOMA-IR levels, alleviating impaired glucose tolerance, reducing blood ALT and AST levels and blood triglyceride and total cholesterol concentrations, and suppressing liver damage, thus being effectively usable for preventing and treating metabolic diseases as well as obesity; and c) ameliorating, preventing or treating leaky gut syndrome, such as selectively promoting the growth of beneficial intestinal microorganisms, improving the destroyed intestinal environment of a host by promoting the production of useful components (short-chain fatty acids) therefrom, recovering beneficial intestinal microorganisms, reducing increased intestinal mucous membrane permeability, and recovering reduced intestinal length. In addition, the Acorus gramineus Solander extract and a fraction thereof can ameliorate, inhibit and prevent intestinal infection caused by pathogenic bacteria, by maintaining the intestinal environment to be slightly acidic. The Acorus gramineus Solander extract and a fraction thereof, of the present invention, are derived from natural products, and thus have no problem with side effects or cytotoxicity.
A61K 36/882 - Acoraceae (Calamus family), e.g. sweetflag or Acorus calamus
A61K 31/715 - Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkagesDerivatives thereof, e.g. ethers, esters
A61P 37/00 - Drugs for immunological or allergic disorders
A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives
The present invention relates to a composition for promoting hair growth, preventing hair loss, or alleviating hair loss, comprising a Lithospermum erythrorhizon extract as an active ingredient. The Lithospermum erythrorhizon extract according to the present invention causes no concern of toxicity and has effects of promoting hair growth and preventing or alleviating hair loss, and thus a food composition, a pharmaceutical composition, a health functional food, a quasi-drug composition, a feed composition, and a cosmetic composition comprising the Lithospermum erythrorhizon extract as an active ingredient can be usefully used for promoting hair growth and preventing or alleviating hair loss.
A23L 33/105 - Plant extracts, their artificial duplicates or their derivatives
A61K 36/30 - Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
A61P 17/14 - Drugs for dermatological disorders for baldness or alopecia
A23K 10/30 - Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hayAnimal feeding-stuffs from material of fungal origin, e.g. mushrooms
The present invention relates to a method for monitoring the quality of red pepper powder, comprising the steps of: estimating at least one of a first particle size and a first moisture content of a first red pepper powder, based on the spectroscopic image data of the first red pepper powder obtained in or before and after at least one of the grinding process, filtration process and sterilization process of red pepper powder; calculating a second spicy level, based on at least one of the first particle size and the first moisture content, and the spectroscopic image data; and estimating a third spicy level of a first mixed red pepper powder in the mixing process, based on at least one of the first particle size and the first moisture content, the second spicy level, and an input amount of the first red pepper powder.
The present invention relates to a plant seed germination promotion method using plasma discharge water, comprising the steps of: (A) preparing plasma-treated discharge water; (B) preparing seeds of a plant on a tray, and then immersing, into the plasma discharge water, the seeds located on the tray; and (C) transplanting the seeds immersed into the plasma discharge water so as to germinate same, and thus, since germination is promoted up to 94.0 to 99.0% on day 1 of transplantation, the germinated plant can be rapidly supplied.
The present invention relates to novel bacteriophages LBC1, LBC2, LEC1, LEC2, or LSE1 and, specifically, to the bacteriophages LBC1, LBC2, LEC1, LEC2, or LSE1 and uses thereof. The novel bacteriophages of the present invention have the capability to inhibit the growth or cause the death of Bacillus, Escherichia coli, or Salmonella and thus can be applied to antibiotics, disinfectants, cleaning agents, food additives, foods, feed additives, feeds, and pharmacological compositions for the prevention or treatment of infections caused by Bacillus, Escherichia coli, or Salmonella.
Cirsium setidensCapsellaSaurus chinensisSaurus chinensis extract as an active ingredient, and thus can ameliorate, prevent, or treat myocardial damage caused by cardiotoxic drugs. In addition, the composition has no toxicity and thus can be taken in the form of a food.
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Asimina trilobaAsimina triloba extract. The Asimina triloba extract according to the present invention has the effect of ameliorating, preventing or treating obesity, lipid metabolism, or lipid-related metabolic diseases, and thus, a pharmaceutical composition, a food composition, a health functional food, a quasi-drug composition, and a feed composition, which comprise the Asimina triloba extract as an active ingredient, can be effectively used for the prevention, treatment or amelioration of obesity.
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
10.
FERMENTATE, PRODUCED BY FERMENTING GINSENG SPROUT TRITURATION WITH NOVEL STRAIN, FOR ANTIOXIDANT OR ANTI-INFLAMMATORY COSMETIC COMPOSITION, PREPARATION METHOD THEREFOR, AND ANTIOXIDANT OR ANTI-INFLAMMATORY COSMETIC COMPOSITION COMPRISING SAME FERMENTATE AS ACTIVE INGREDIENT
Proposed is a quality analysis nanosensor using a metastructure, including: a metasurface structure resonating with a specific frequency of incident electromagnetic waves; a fixed binding body formed on a surface of the metasurface structure or inside the metasurface structure on a hotspot area; a movable binding body coupled to the fixed binding body by an attractive force; and a receptor or nanoparticles linked to the movable binding body. According to the nanosensor, there are provided a detection structure and method based on metamaterials and nanoparticles, thereby enabling efficient detection with only few nanoparticles by raising detection sensitivity to a high level.
The present invention relates to a composition for preventing or treating cancer, the composition comprising, as an active ingredient, Weissella paramesenteroides WiKim0137 or a culture thereof isolated from kimchi. The Weissella paramesenteroides WiKim0137 or culture thereof according to the present invention exhibits excellent anticancer activity and can thus be effectively used as a composition for treating, preventing, or alleviating human or animal cancer.
The present invention relates to a composition for prevention or treatment of cancer, the composition containing, as an active ingredient, a Leuconostoc pseudomesenteroides WiKim0138 strain isolated from kimchi or a culture thereof. The Leuconostoc pseudomesenteroides WiKim0138 strain or the culture thereof according to the present invention exhibits excellent anticancer activity, and thus can be advantageously used as a composition for use in treatment, prevention, or alleviation of human or animal cancer.
The present invention relates to a method for detecting a food-noxious substance and, more specifically, to a method for detecting a food-noxious substance wherein, with selective molecular affinity, a food-noxious substance-specific aptamer is bound to a capture probe fixed to a chip in the absence of the food-noxious substance, but departs from the capture probe and binds to the food noxious substance in the presence of the food-noxious substance, so that a circular DNA binds to the capture probe and undergoes an RCA reaction to form a metal body for signal amplification, whereby detection accuracy can be improved.
Artemisia gmeliniiArtemisia gmelinii extract as an active ingredient. Exhibiting immunopotentiation effects by proliferating T cells, increasing the production of the cytokines IL-2 and IFN-γ, the peritoneal macrophage-activating cytokines IL-6, TNF-α, and IL-12p70, and the immune cells whole blood cells (WBC), neutrophils, lymphocytes, and monocytes, upregulating the expression levels of serum IgG and fecal sIgA, and augmenting the activity of natural killer cells, the Artemisia gmelinii extract of the present invention can be advantageously used as an immunopotentiator. In addition, the Artemisia gmelinii extract of the present invention is stable in vivo because not causing cytotoxicity, and thus can also be utilized even in an immunopotentiation food composition, pharmaceutical composition, quasi-drug composition, or feed composition.
A23K 10/30 - Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hayAnimal feeding-stuffs from material of fungal origin, e.g. mushrooms
17.
COMPOSITION FOR PREVENTING, ALLEVIATING OR TREATING METABOLIC DISEASES, COMPRISING PASSIFLORA CAERULEA EXTRACT
The present invention relates to a composition for preventing, alleviating or treating metabolic diseases, containing a Passiflora caerulea extract as an active ingredient. The composition has the effects of reducing the expression of adipogenesis proteins so as to reduce fat tissue, reducing triglyceride and total cholesterol, and reducing body weight, and thus can be effectively used in the prevention, alleviation or treatment of metabolic diseases.
A61P 3/10 - Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
A61P 9/10 - Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Leuconostoc citreumcitreum WiKim0129 isolated from kimchi and a composition comprising same. The Leuconostoc citreum WiKim0129 according to the present invention exhibits excellent anticancer effects and thus can be variously applied to the prevention, alleviation, and treatment of cancerous diseases.
LactiplantibacillusparaplantarumWiKim0130WiKim0130 isolated from kimchi and a composition comprising same. The Lactiplantibacillus paraplantarum WiKim0130, according to the present invention, exhibits an excellent anticancer effect and thus may be variously employed for the use of prevention, reduction and treatment of a cancer disease.
The present invention relates to a food composition for enhancing respiratory function and improving respiratory diseases, using Lactobacillus plantarum KF511 strain; a health functional food comprising the food composition; and a pharmaceutical composition for preventing or treating the respiratory diseases, comprising Lactobacillus plantarum strain, its culture solution, its concentrate, or its dried product, as an active ingredient.
The present invention relates to a food composition for enhancing respiratory function and improving respiratory diseases, using Lactobacillus plantarum KF511 strain; a health functional food comprising the food composition; and a pharmaceutical composition for preventing or treating the respiratory diseases, comprising Lactobacillus plantarum strain, its culture solution, its concentrate, or its dried product, as an active ingredient.
The Lactobacillus plantarum KF511 strain, according to the present invention shows activities of inhibiting secretion of MUC5AC in a mucus hypersecretion model using a respiratory epithelial cell (H292) of a human, inhibiting Netosis activation of neutrophil extracellular traps, inhibiting expression of inflammatory cytokines by Cigarette Smoke Extraction (CSE) of NCI-H292 cells that are a bronchial epithelial cell line, and furthermore, inhibiting damage of a lung tissue in a mouse model of a respiratory disease induced by the CSE and PPE, inhibiting infiltration of immune cells such as total cells, macrophages, lymphocytes, eosinophils, and neutrophils in BALF, and inhibiting secretion of inflammatory cytokines and chemokines in the BALF and the lung tissue.
The present invention relates to: a composition, for diagnosis of lung cancer or for prediction of onset risk of lung cancer, comprising an agent capable for detecting oral microbiome; a kit comprising same; and an information provision method for diagnosis of lung cancer or for prediction of onset risk of lung cancer or for prognosis of lung cancer, wherein a saliva-derived oral microbiome is analyzed, whereby the present invention can make rapid and accurate early diagnosis of lung cancer, enables the prediction of onset risk of lung cancer and the prognosis of lung cancer, and thus can be advantageously used for prevention or treatment of lung cancer.
C12Q 1/6886 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
22.
COMPOSITION CONTAINING GELLAN GUM AS ACTIVE INGREDIENT FOR IMPROVING GUT MICROBIOTA AND COMPOSITION CONTAINING SAME FOR ALLEVIATION, PREVENTION, OR TREATMENT OF METABOLIC DISEASE
The present invention relates to a composition for improving gut microbiota and for alleviating, preventing, or treating metabolic diseases, wherein the composition contains gellan gum as an active ingredient to promote the proliferation of beneficial gut bacteria, inhibit an increase in body weight and body fat, reduce serum levels of endotoxins, cholesterol, and LDL cholesterol, and repress expression of liver injury indicators and hepatic inflammation indicators.
A23L 33/125 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing carbohydrate syrupsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugarsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugar alcoholsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing starch hydrolysates
A23L 33/21 - Addition of substantially indigestible substances, e.g. dietary fibres
A61K 31/715 - Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkagesDerivatives thereof, e.g. ethers, esters
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
The present invention relates to a microneedle patch, for sensing food quality, comprising: a patch base placed on food; and a plurality of microneedles protruding on the bottom surface of the patch base and inserted into the food. According to the present invention, changes in the internal quality of food can be measured and monitored in real time without a preprocessing step for the food, destruction of the food can be minimized by efficiently extracting an internal factor, and an economical sensing system capable of highly sensitive multi-sensing at a low cost can be provided by reducing manufacturing cost by means of the sensing system having a simple structure, and enhancing surface sensing sensitivity.
The present invention relates to a composition for preventing, alleviating or treating muscle diseases, a composition for strengthening muscles, a composition for promoting muscle differentiation, or a composition for improving exercise capacity, all of the compositions containing an extract of Gardenia jasminoides as an active ingredient, wherein the compositions promote muscle differentiation, inhibit muscle atrophy factors and myodifferentiation inhibitory factors and increases myodifferentiation regulatory factors, and thus can be effectively used in the prevention, alleviation or treatment of muscle diseases.
The present invention relates to a strain having liver function improving activity, and a use thereof. Specifically, the present invention relates to a health food composition for improving liver function and a pharmaceutical composition for improving liver function, which contain, as an active ingredient, one or more strains selected from the group consisting of a Lactobacillus pentosus KF8 (accession number KCCM11997P) strain, a Bacillus subtilis KF11 (accession number KCCM11981P) strain, and a Lactococcus lactis KF140 (accession number KCCM11673P) strain, a lysate thereof or a culture product thereof. The strain of the present invention shows excellent activity in inhibiting the activity of alanine aminotransferase (ALT) or aspartate aminotransferase (AST), inhibiting an increase in the concentration of total cholesterol or triglycerides in the liver, and inhibiting fat accumulation in the liver, thereby being effectively usable in the preparation of a food composition and a pharmaceutical composition for improving liver function.
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A23L 33/00 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof
A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
27.
COMPOSITION, FOR RELIEVING MUSCULAR DISEASE AND INCREASING MUSCLE MASS, COMPRISING SESAME DREGS
The present invention relates to a composition, for relieving muscular disease and increasing muscle mass, comprising sesame dregs. An ethanol fraction of a hot-water sesame dreg extract exhibits effects including sarcopenia relief, increased muscle mass and enhanced motor ability due to same, and thus can be effectively used in relieving, preventing or treating muscle disease, increasing muscle mass and enhancing motor ability.
The present disclosure relates to novel Lactobacillus sakei WIKIM0109 isolated from kimchi and a composition containing the same. The Lactobacillus sakei WIKIM0109 according to the present disclosure is a lactic acid bacterium having an activity of inhibiting IgG and IgG2a production in blood and an activity of inhibiting IFN-γ, IL-17 and TNF-α production, and can be used in various applications, such as for preventing and ameliorating arthritis or improving intestinal regulation in human or animals.
A23C 9/123 - Fermented milk preparationsTreatment using microorganisms or enzymes using only microorganisms of the genus lactobacteriaceaeYoghurt
A23K 10/12 - Animal feeding-stuffs obtained by microbiological or biochemical processes by fermentation of natural products, e.g. of vegetable material, animal waste material or biomass
A23K 10/18 - Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
A61P 19/02 - Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
The present disclosure relates to a composition for discriminating the species Lactobacillus acidophilus, which enables microorganisms belonging to the species Lactobacillus acidophilus to be discriminated, detected and identified simply, quickly and accurately from a target sample. Therefore, the present disclosure can be effectively used in the development of fermented milk, baby food, dairy products, livestock feed, cosmetics, health supplements, drugs for intestinal disorders, raw materials, etc. using the Lactobacillus acidophilus sp. strain.
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
30.
JELLYFISH PRETREATMENT METHOD FOR COLLAGEN EXTRACTION, AND JELLYFISH COLLAGEN EXTRACTION METHOD USING SAME
The present invention relates to: a jellyfish pretreatment method for collagen extraction; a jellyfish collagen extraction method using the pretreatment method; and a cosmetic composition for improving skin condition, wherein the cosmetic composition contains, as an active ingredient, jellyfish collagen extracted by the extraction method. The jellyfish pretreatment method according to the present invention can be used to minimize the moisture of jellyfish and thereby increase collagen extraction efficiency, and can reduce production costs and facilitate mass production. The jellyfish collagen extracted by the extraction method according to the present invention exhibits whitening activity, inflammation inhibitory activity, and collagenase MMP-1 inhibitory activity, and therefore the composition containing the jellyfish collagen can be useful as a cosmetic composition for improving skin condition.
A61K 8/98 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution of animal origin
A61K 8/64 - ProteinsPeptidesDerivatives or degradation products thereof
Pediococcus inopinatus strain can suppress neuroinflammation and can also alleviate the symptoms of ataxia in an animal model of Parkinson's disease and, thus, can be utilized for the prevention, alleviation and treatment of various neurodegenerative diseases including Parkinson's disease.
The present invention relates to a novel Lactobacillus fermentum WiKim0102 (Accession No. KCCM12356P) isolated from kimchi and a composition comprising the same as an active ingredient. Lactobacillus fermentum WiKim0102 according to the present invention shows excellent anti-cancer activity in conventional animal models and animal models in which a human cancer cell is transplanted, and therefore it can be usefully used as a composition in use of treatment, prevention or improvement of cancer of humans or animals.
The present disclosure relates to a composition for preventing, alleviating or treating depression or anxiety disorder, which contains Lactobacillus sakei as an active ingredient. The Lactobacillus sakei strain according to the present disclosure can be used to prevent, alleviate or treat a mental disorder such as depression or anxiety disorder.
Schisandra chinensis fruit water and bean juice as active ingredients, has a high inhibitory activity against α-glucosidase and prevents a rise of the blood sugar after meals, thereby alleviating diabetes. The food composition for alleviating diabetes can be prepared in different forms, such as soy milk, powdered soy milk, other forms of soy milk, or processed bean curd, and used in the preparation of health functional foods for blood sugar control or foods for diabetics according to the Special Purpose Foods of the general foods. In addition, the food composition for alleviating diabetes according to the present invention, when further containing a saccharified material of grain, maintains viscosity similar to that of regular soy milk by preventing agglomeration of the liquid soy milk and improves sensory properties, so it can be suitable for use in beverages such as soy milk or other forms of soy milk.
Hippophae rhamnoidesHippophae rhamnoides leaf extract as an active ingredient and as such, can alleviate, prevent, or treat diseases caused by diabetes mellitus complications and can be used as a food composition and furthermore as a health functional food or a pharmaceutical composition, a feed composition, or a pharmaceutical composition for animals.
A23K 20/00 - Accessory food factors for animal feeding-stuffs
A23K 10/30 - Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hayAnimal feeding-stuffs from material of fungal origin, e.g. mushrooms
36.
ONE-STOP DETECTION SYSTEM FOR RAPID AND SIMULTANEOUS DETECTION OF FOOD POISONING BACTERIA
The present invention relates to a one-stop detection system and, more particularly to, a one-stop detection system wherein a sample preprocessing device and a detection and diagnosis device capable of preprocessing a sample for detection of multiple types of food poisoning bacteria and detecting a gene are integrally formed with each other, and transport of a sample between the sample preprocessing device and the detection and diagnosis device is automatically performed by a sample transport device, whereby even non-specialist can quickly detect multiple types of food poisoning bacteria from a sample in the field.
Leuconostoc citreum WiKim0104 according to the present invention shows an inhibitory effect for fatty liver production by inhibiting fat accumulation in liver cells and reducing expression of fatty liver-related genes, and thus it may be variously utilized for uses in prevention, improvement and treatment of inflammation, obesity or fatty liver disease.
A61K 35/744 - Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
A23L 29/00 - Foods or foodstuffs containing additivesPreparation or treatment thereof
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
38.
COMPOSITION FOR PREVENTING, AMELIORATING OR TREATING MUSCLE WEAKNESS-RELATED MUSCLE DISEASES COMPRISING CHESTNUT FLOWER EXTRACT
The present invention relates to a composition for preventing, improving or treating muscle weakness-related muscle diseases, comprising a chestnut flower extract as an active ingredient. The composition is effective in the amelioration or treatment of muscle weakness-related muscle diseases, has the effect of strengthening muscle strength and improving exercise performance, and has anti-aging efficacy or life extension efficacy by inducing or increasing autophagy activity, and thus can be usefully used in the pharmaceutical field and the food field.
The present invention relates to a novel Weissella cibaria WIKIM28 (Accession No. KCCM11879P) isolated from kimchi and a composition comprising the same as an active ingredient. Weissella cibaria WIKIM28 according to the present invention shows excellent anti-cancer activity in animal models in which a cancer cell is transplanted, and therefore it can be usefully used as a composition in use of treatment, prevention or improvement of cancer of humans or animals.
A23L 33/00 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof
A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
A23K 10/18 - Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
40.
COMPOSITION FOR PREDICTING OR DIAGNOSING DISEASE RISK USING INTESTINAL MICROBES, DIAGNOSTIC KIT USING SAME, METHOD FOR PROVIDING INFORMATION, AND METHOD FOR SCREENING AGENT FOR PREVENTING OR TREATING DIABETES
The present invention relates to: a composition which is for predicting or diagnosing the risk of at least one disease selected from among diabetes, obesity, liver disease, and renal disease by using intestinal microbes; a diagnostic kit which is for predicting diagnosing disease risk and comprises the composition; a method for providing information for predicting or diagnosing the risk of disease; and a method for screening an agent for preventing or treating a disease. The present invention makes it possible to predict or diagnose disease risk through an agent capable of detecting a biomarker strain that can detect the disease, and screen an agent for preventing or treating the disease.
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
41.
Lactobacillus paracasei AO356 strain having anti-obesity activity and method for preventing, alleviating or treating obesity using the same
Lactobacillus paracasei AO356 strain according to the present disclosure, which is a strain isolated from the human body, has high stability, exhibits the activity of inhibiting adipogenic differentiation in vitro and inducing the differentiation of M1 and M0 macrophages into M2 macrophages, and has excellent activity of alleviating, preventing, or treating obesity, such as the activity of reducing body weight and a reduction in blood lipid concentration through the browning of white fat in animal experiments. Thus, the novel strain of the present disclosure has a low possibility of causing side effects, and therefore, unlike conventional diet functional foods or drugs, which have side effect problems, a diet effect can be exhibited without controlling the dose thereof. Accordingly, the novel strain can be used as a pharmaceutical composition for treating or preventing obesity or a food composition for alleviating or preventing obesity.
SOOKMYUNG WOMEN'S UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (Republic of Korea)
KOREA FOOD RESEARCH INSTITUTE (Republic of Korea)
Inventor
Yoon, Yohan
Lim, Sang Dong
Ha, Jimyeong
Kim, Seul Ki
Kang, Joohyun
Choi, Yuna
Hong, Sang Pil
Chin, Young Wook
Lee, Myung Ki
Abstract
Weissella cibariaWeissella cibariaWeissella cibaria KI35 strain in the present invention reduces a weight gain rate through inhibition of pancreatic lipase activity, inhibition of α-amylase and α-glucosidase activity, and inhibition of obesity cell differentiation, and reduces the expression of proteins and genes related to obesity and inflammation in organs such as the liver and adipose tissue, thereby exhibiting the effects of preventing, ameliorating, or treating obesity and fatty liver disease.
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
43.
NOVEL PEDIOCOCCUS PENTOSACEUS STRAIN AND FOOD COMPOSITION FOR PREVENTING OR IMPROVING OBESITY OR FATTY LIVER DISEASE COMPRISING WHEY FERMENTED PRODUCT THEREOF
SOOKMYUNG WOMEN'S UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (Republic of Korea)
KOREA FOOD RESEARCH INSTITUTE (Republic of Korea)
Inventor
Yoon, Yohan
Lim, Sang Dong
Ha, Jimyeong
Kim, Seul Ki
Kang, Joohyun
Choi, Yuna
Hong, Sang Pil
Chin, Young Wook
Lee, Myung Ki
Abstract
Pediococcus pentosaceusP. P. pentosaceus KI13 strain reduces a weight gain rate through inhibition of pancreatic lipase activity, inhibition of α-amylase and α-glucosidase activity, and inhibition of mast cell differentiation, and reduces the expression of genes and proteins related to obesity and inflammation in organs, such as the liver, and adipose tissue, thereby exhibiting an effect of preventing, improving, or treating obesity and fatty liver disease.
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
44.
COMPOSITION FOR CONTROLLING HARMFUL ORGANISMS COMPRISING LACTOBACILLUS SAKEI WIKIM0118 STRAIN OR CULTURE SOLUTION THEREOF
INDUSTRY FOUNDATION OF CHONNAM NATIONAL UNIVERSITY (Republic of Korea)
KOREA FOOD RESEARCH INSTITUTE (Republic of Korea)
Inventor
Lee, Jun Ho
Chang, Ji Yoon
Abstract
Lactobacillus sakeiLactobacillus sakei WiKim0118 strain or a culture solution thereof. The composition exhibits excellent effects in regulating the activity of nematode GABA receptors, nematicidal action, oviposition control and larval apoptosis, and thus can be effectively used for the preparation of nematicides.
Composition comprising Molokhia extract as active ingredient for improving gut microbiome or for alleviating, preventing, or treating intestinal inflammation, leaky gut syndrome, obesity, or metabolic disease
The present invention relates to a prebiotic composition, a composition for improving gut microorganisms, a composition for improving gut health or gut function, a composition for alleviating, preventing, or treating inflammatory bowel disease or leaky gut syndrome, or a composition for alleviating, preventing, or treating obesity or metabolic disease, which each comprise a molokhia extract or a molokhia polymer fraction as an active ingredient to induce the proliferation of beneficial intestinal bacteria and to improve, prevent, or treat gut heath or gut function. In addition, the composition comprising a molokhia extract or a molokhia polymer fraction as an active ingredient can alleviate, prevent, or treat bowel disease or leaky gut syndrome. Moreover, the composition of the present invention comprises a molokhia extract or a molokhia polymer fraction as an active ingredient that improves immunological activity as well as having anti-obesity activity, thereby not only treating obesity, but also alleviating, preventing, or treating obesity-induced metabolic diseases and as such, is very advantageous.
The present invention relates to a quality analysis nanosensor using a metastructure, the nano sensor comprising: a metasurface structure which resonates with respect to a specific frequency of an incident electromagnetic wave; a fixed binding body which is formed on a surface in a hotspot area of the metasurface structure or is formed inside the structure; a movable binding body which is coupled to the fixed binding body by an attractive force; and a receptor or nanoparticle which is linked to the movable binding body. The present invention may provide a detection structure and a detection method which are based on a metamaterial and a nanoparticle and enable efficient detection only with a small amount of nanoparticles while highly increasing the detection sensitivity.
Composition including, as active ingredient, strain having ability to produce formic acid for preventing or treating obesity or metabolic syndromes caused by obesity
The present invention relates to a composition comprising as an active ingredient a strain having excellent ability to produce formic acid for preventing or treating obesity or metabolic syndromes caused by obesity; and to a food composition and a health functional food each comprising the active ingredient. The strain having excellent ability to produce formic acid according to the present invention not only has effects of reducing body weight and inhibiting fat accumulation in organs, but also has activity to effectively lower blood triglyceride and cholesterol levels, and therefore, the composition comprising the strain as an active ingredient can be favorably used as a composition capable of preventing/alleviating or treating obesity or metabolic syndromes caused by obesity. Therefore, the strain having excellent ability to produce formic acid according to the present invention can be favorably used as a material for a medical product or health food.
KOREA INSTITUTE OF ORIENTAL MEDICINE (Republic of Korea)
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (Republic of Korea)
Inventor
Jang, Dai Ja
Yang, Hye Jeong
Kim, Min Jung
Cho, Dae-Kwan
Ko, Byoung Seob
Ahn, Sang Woo
Lee, Minho
Lee, Jeoung Hwa
Ryuk, Jin Ah
Kim, Yong-Bum
Im, Wan-Jung
Abstract
The present invention relates to an alimentotherapy technique by which a therapeutic effect is obtained through food. A method for an alimentotherapy information system to manage alimentotherapy information comprises: receiving an input of ancient literature material including past alimentotherapy literature and culinary literature; extracting original information from the input ancient literature material, wherein the original information includes herbal medicine information for alimentotherapy and food information required for cooking; generating ingredient information, including site of activity, processing method, blending composition, medicinal properties and effectiveness, administration method, etc., from the extracted original information, and many-to-many matching foods to the medicines, wherein the original information is integrated on the basis of a single subject matter; and refining the alimentotherapy information of the integrated original information so as to conform to modern safety standards by referencing modern medical information, food ingredient compositions, and safety information.
G16H 20/60 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to nutrition control, e.g. diets
G16H 70/60 - ICT specially adapted for the handling or processing of medical references relating to pathologies
G16H 20/90 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to alternative medicines, e.g. homeopathy or oriental medicines
G16H 20/10 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
G16H 50/70 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
G16H 80/00 - ICT specially adapted for facilitating communication between medical practitioners or patients, e.g. for collaborative diagnosis, therapy or health monitoring
50.
COMPOSITION FOR RELIEVING HANGOVER CONTAINING PEDIOCOCCUS INOPINATUS AS ACTIVE INGREDIENT
KOREA INSTITUTE OF ORIENTAL MEDICINE (Republic of Korea)
KOREA FOOD RESEARCH INSTITUTE (Republic of Korea)
Inventor
Chae, Sung Uk
Shim, Ki-Shuk
Hong, Sung Wook
Roh, Seong Woon
Hwang, Hye-Lyeon
Lee, Ho Jae
Abstract
The present invention relates to a composition for relieving a hangover, containing Pediococcus inopinatus as an active ingredient. Specifically, Pediococcus inopinatus WiKim0108 not only has no cytotoxicity, but also reduces the content of ethanol and acetaldehyde in blood that has been increased by ingestion of alcohol, effectively increases ADH and ALDH activity in the blood, and has a gastrointestinal protective function. Thus, the composition of the present invention can be effectively used as a functional health food or medicine for hangover relief or alcoholic gastrointestinal diseases.
A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
A61K 35/744 - Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
51.
SIKCHIJEHO-TANG COMPOSITION FOR ENHANCING BLOOD CIRCULATION
KOREA INSTITUTE OF ORIENTAL MEDICINE (Republic of Korea)
KOREA FOOD RESEARCH INSTITUTE (Republic of Korea)
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (Republic of Korea)
Inventor
Ko, Byoung Seob
Ahn, Sang Woo
Ryuk, Jin Ah
Kim, Hye Jin
Hwang, Joo Tae
Jang, Dai Ja
Yang, Hye Jeong
Kim, Min Jung
Kim, Yong-Bum
Im, Wan-Jung
Abstract
A Sikchijeho-tang composition of the present invention exhibits a blood circulation-enhancing effect as high as or higher than that of Gagamjeho-tang comprising a smoky Prunus mume fruit, a Amomum villosum LOUR. fruit, an Amomum tsao-ko fruit, and a Pterocarpus santalinus stem and is free of an Amomum tsao-ko fruit and a Pterocarpus santalinus stem, which are both prohibited from being used as foods, and employs either Agastache rugosa or Agastache rugosa and Citrus maxima, whereby the composition can be industrially prepared into foods, beverages, and medicinal products.
A high resolution inspection apparatus using a terahertz Bessel beam. The high resolution inspection apparatus comprises a terahertz wave generating unit for generating a terahertz wave; a Bessel beam forming unit for generating a terahertz Bessel beam using the terahertz wave incident from the terahertz wave generating unit; a ring beam forming unit for forming a ring beam using the terahertz Bessel beam and concentrating the formed ring beam to an inspection target object; a scattered light detecting unit for detecting scattered light generated from the inspection target object; and a ring beam detecting unit for detecting a ring beam transmitted through the inspection target object.
G01V 8/10 - Detecting, e.g. by using light barriers
G01N 21/3581 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using far infrared lightInvestigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using Terahertz radiation
G01V 8/14 - Detecting, e.g. by using light barriers using one transmitter and one receiver using reflectors
G01V 8/18 - Detecting, e.g. by using light barriers using one transmitter and one receiver using mechanical scanning systems
53.
COMPOSITION FOR MUSCULAR FUNCTION ENHANCEMENT COMPRISING GINSENOSIDE RF, GINSENOSIDE COMPOSITION COMPRISING GINSENOSIDE RF, OR MIXTURE OF ANY ONE OR MORE THEREOF AS ACTIVE INGREDIENT
Ginsenoside Rf, a ginsenoside composition comprising ginsenoside Rf, or a mixture of any one or more thereof, of the present invention, promotes the expression of a myosin heavy chain, which is a muscle differentiation marker, regulates energy homeostasis in the body, promotes the phosphorylation of AMPK, which plays an important role in the regulation of skeletal muscle development and growth, and in the forced swimming test in animal experiments, increases swimming duration, thereby increasing exercise ability, muscle strength, and muscle mass and alleviating muscle atrophy, and thus can be used as a food composition for muscular function enhancement, a cosmetic composition for muscular function enhancement, a food composition for alleviation or prevention of sarcopenia, or a pharmaceutical composition for treatment or prevention of sarcopenia.
A61Q 90/00 - Cosmetics or similar toiletry preparations for specific uses not provided for in other groups of this subclass
A61K 31/704 - Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin, digitoxin
A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
A23L 5/00 - Preparation or treatment of foods or foodstuffs, in generalFood or foodstuffs obtained therebyMaterials therefor
54.
COMPOSITION, USING LACTOBACILLUS PLANTARUM STRAIN OR LIKE, FOR ALLEVIATION OF RESPIRATORY DISEASES
Lactobacillus plantarumEpilobium angustifolium L.Artemisia capillaris Thunb.Lactobacillus plantarumLactobacillus plantarum KF511 strain, Epilobium angustifolium L. extract, or Artemisia capillaris Thunb. extract of the present invention exhibits activities to inhibit secretion of MUC5AC, inhibit NETosis activation of neutrophil extracellular traps, and inhibit inflammatory cytokine expression induced by cigarette smoke extraction (CSE) in bronchial epithelial cell line NCI-H292 cells, in mucus hypersecretion models using human respiratory epithelial cells (H292), and furthermore, exhibits abilities to inhibit lung tissue damage, inhibit the infiltration of total cells or immune cells, such as macrophages, lymphocytes, eosinophils, and neutrophils, in BALF, and inhibit inflammatory cytokine and chemokine secretion in BALF and lung tissues, in CSE- and PPE-induced respiratory disease mouse models.
A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
A61K 35/747 - Lactobacilli, e.g. L. acidophilus or L. brevis
A61P 11/00 - Drugs for disorders of the respiratory system
55.
Paper-based colorimetric sensor kit for quickly and simply diagnosing mercury in situ with naked eye and method for quickly and simply detecting mercury in situ with naked eye using the same
There is provided a paper-based colorimetric sensor kit for quickly and simply diagnosing mercury in situ with a naked eye. The paper-based colorimetric sensor kit includes: a circular template for rolling circle amplification (RCA); a primer that does not hybridize to the circular template when a mercury ion is bonded to a primer that hybridizes to the circular template; a DNA polymerase; a sensing material kit including a nanoparticle probe labeled to a DNA coil formed in the circular template for RCA; and a radial chromatography paper.
KOREA INSTITUTE OF ORIENTAL MEDICINE (Republic of Korea)
Inventor
Kim, Myungsun
Park, Jaeho
Hong, Moonju
Yang, Hyejeong
Kim, Minjung
Kim, Soonhee
Hur, Haengjeon
Cha, Minho
Yim, Namhui
Abstract
The present invention relates to a composition that comprises a preparation that measures the methylation level of the promoter region of the natriuretic peptide receptor 2 (NPR2) gene, and thus can predict or diagnose hypertension or obesity even when a symptom thereof is not identified visually or from other results, or even at a very early stage.
C12Q 1/6883 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
57.
COMPOSITION COMPRISING ENTEROCOCCUS LACTIS AS ACTIVE INGREDIENT FOR PREVENTION, ALLEVIATION, OR TREATMENT OF FATTY LIVER DISEASE
KOREA INSTITUTE OF ORIENTAL MEDICINE (Republic of Korea)
KOREA FOOD RESEARCH INSTITUTE (Republic of Korea)
Inventor
Chae, Sung Uk
Lee, Joo Young
Hong, Sung Wook
Roh, Seong Woon
Lee, Ho Jae
Abstract
22, lowers ALT levels in an animal model in which a fatty liver has been induced by a high-fat diet, decreases liver weight, and downregulates the expression level of a fat metabolism-related gene in the liver, thereby finding advantageous applications as a health functional food, a medicine, a feed additive, or a veterinary composition for prevention, alleviation, or treatment of fatty liver disease.
A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
A61K 35/744 - Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A23K 10/16 - Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
KOREA INSTITUTE OF ORIENTAL MEDICINE (Republic of Korea)
KOREA FOOD RESEARCH INSTITUTE (Republic of Korea)
Inventor
Chae, Sung Uk
Lee, Joo Young
Shim, Ki-Shuk
Hong, Sung Wook
Roh, Seong Woon
Lee, Ho Jae
Abstract
22), reducing ALT and TG content in blood which has been increased by alcohol, lowering ALT levels in an animal model in which fatty liver has been induced through a high-fat diet, reducing the weight of the liver, and reducing the expression level of a lipid metabolism-associated gene in the liver, and thus the composition of the present invention may be usefully employed as a health functional food, medicine, feed additive or veterinary composition for preventing, improving or treating fatty liver disease.
A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
A61K 35/744 - Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
A23K 10/16 - Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
METHOD FOR PREPARATION OF ULTRASONICATED YEAST EXTRACT HAVING EXCELLENT INHIBITORY ACTIVITY AGAINST SKIN CANCER AND SKIN CANCER-INHIBITING COMPOSITION COMPRISING ULTRASONICATED YEAST EXTRACT PREPARED BY SAME METHOD
The present invention relates to: a composition comprising an ultrasonicated yeast extract for prevention, alleviation, or treatment of skin cancer; and a preparation method therefor, wherein the ultrasonicated yeast extract has a remarkable inhibitory activity against the proliferation of skin cancer cells and can be advantageously used in cosmetic, functional food, and medicinal fields.
The present invention relates to a method of analyzing allulose in food, and a quality control method for food containing allulose, using same. More specifically, the present invention provides a method of establishing conditions that allow allulose to be extracted from food with a high recovery rate.
COMPOSITION FOR PREVENTING, ALLEVIATING OR TREATING HOT FLASHES, TINGLING OF LIMBS OR PALPITATION IN MENOPAUSAL WOMEN, CONTAINING LACTOBACILLUS ACIDOPHILUS
Lactobacillus acidophilusLactobacillus acidophilusLactobacillus acidophilus YT1 strain according to the present invention is provided to the human body in a food item, effects in which hot flashes, tingling of limbs, palpitation and the like are alleviated in menopausal women are exhibited after the administration of the food item containing the strain. Therefore, it is expected that a composition containing the Lactobacillus acidophilus, according to the present invention, can be effectively used for a use of preventing, alleviating or treating hot flashes, tingling of limbs or palpitation in menopausal women.
COMPOSITION COMPRISING LACTOBACILLUS ACIDOPHILUS FOR PREVENTING, ALLEVIATING, OR TREATING ARTHROMYALGIA, HEADACHES, OR VAGINAL DRYNESS IN CLIMACTERIC WOMEN
Lactobacillus acidophilusLactobacillus acidophilusLactobacillus acidophilus YT1 according to the present invention through food to a human body, the effect of alleviating arthromyalgia, headaches, vaginal dryness, etc. was shown in climacteric women after ingesting food comprising said strain. Accordingly, the composition comprising said Lactobacillus acidophilus strain according to the present invention is expected to be usefully employed in preventing, alleviating, or treating arthromyalgia, headaches, or vaginal dryness in climacteric women.
The present invention relates to a strain showing liver function improving activity, and a use thereof. Specifically, the present invention relates to a health food composition for improving liver function and a pharmaceutical composition for improving liver function, which contain, as an active ingredient, one or more strains selected from the group consisting of a Lactobacillus pentosus KF8 (accession number KCCM11997P) strain, a Bacillus subtilis KF11 (accession number KCCM11981P) strain, and a Lactococcus lactis KF140 (accession number KCCM11673P) strain, a lysate thereof or a culture product thereof. The strain of the present invention shows excellent activity in inhibiting the activity of alanine aminotransferase (ALT) or aspartate aminotransferase (AST), inhibiting an increase in the concentration of total cholesterol or triglycerides in the liver, and inhibiting fat accumulation in the liver, thereby being effectively usable in the preparation of a food composition and a pharmaceutical composition for improving liver function.
A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
A61K 35/747 - Lactobacilli, e.g. L. acidophilus or L. brevis
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
COMPOSITION COMPRISING LACTOBACILLUS ACIDOPHILUS FOR PREVENTING, ALLEVIATING, OR TREATING NERVOUSNESS, FORMICATION, INSOMNIA, VERTIGO, OR FATIGUE IN MENOPAUSAL WOMEN
Lactobacillus acidophilusLactobacillus acidophilusLactobacillus acidophilus YT1 strain according to the present invention to a food which is consumed by the human body, it was observed that nervousness, formication, insomnia, vertigo, or fatigue was alleviated in menopausal women who had taken a food containing the strain. Therefore, the composition comprising the Lactobacillus acidophilus according to the present invention is expected to be advantageously applied to the treatment, alleviation, or treatment of nervousness, formication, insomnia, vertigo, or fatigue in menopausal women.
KOREA INSTITUTE OF ORIENTAL MEDICINE (Republic of Korea)
KOREA FOOD RESEARCH INSTITUTE (Republic of Korea)
Inventor
Chae, Sung Uk
Ji, Kon-Young
Hong, Sung Wook
Roh, Seong Woon
Lee, Ho Jae
Abstract
The present invention relates to a strain of lactic acid bacteria, Pediococcus inopinatus, having an effect of regulating immune function and alleviating inflammatory bowel disease, and a use thereof. The strain, Pediococcus inopinatus, has no cytotoxicity, has an immunity enhancing effect, has an effect of promoting NO production and ROS production, increases the expression of inflammatory cytokines and the number of immunocytes, and has an effect of alleviating bowel disease in an animal model of inflammatory bowel disease. Accordingly, the Pediococcus inopinatus can be very usefully utilized in functional health foods, medicines, feed compositions, and veterinary compositions for regulating immune function and preventing, alleviating, or treating inflammatory bowel disease.
A23K 10/16 - Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
A61K 35/744 - Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
A61P 1/04 - Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
KOREA INSTITUTE OF ORIENTAL MEDICINE (Republic of Korea)
KOREA FOOD RESEARCH INSTITUTE (Republic of Korea)
Inventor
Chae, Sung Uk
Im, A-Rang
Hong, Sung Wook
Roh, Seong Woon
Lee, Ho Jae
Abstract
The present invention relates to a composition for preventing, ameliorating, or treating skin wrinkles and moisturizing skin, comprising Pediococcus inopinatus as an active ingredient. Specifically, Pediococcus inopinatus remarkably inhibits the expression of MMP-1 and MMP-9 increased by UV irradiation, reduces skin thickness by easing the stratum corneum, enhances skin moisture content, reduces the amount of transdermal moisture loss, and increases the content of hyaluronic acid. Therefore, the composition of the present invention can be used as: a cosmetic composition for ameliorating skin wrinkles or moisturizing the skin; a health functional food composition for ameliorating skin wrinkles or moisturizing the skin; a pharmaceutical composition for preventing or treating xeroderma; a feed composition for ameliorating skin wrinkles or moisturizing the skin; and a veterinary composition for ameliorating skin wrinkles or moisturizing the skin.
A61K 8/99 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
KOREA INSTITUTE OF ORIENTAL MEDICINE (Republic of Korea)
KOREA FOOD RESEARCH INSTITUTE (Republic of Korea)
Inventor
Chae, Sung Uk
Ji, Kon-Young
Hong, Sung Wook
Roh, Seong Woon
Lee, Ho Jae
Abstract
The present invention relates to lactic acid bacteria Enterococcus lactis having effects of regulating immune functions and alleviating an inflammatory bowel disease and use thereof. The Enterococcus lactis has no cytotoxicity, has an immune-boosting effect and NO generation and ROS generation increasing effects, increases the expression of inflammatory cytokines and the number of immune cells, and has a bowel disease alleviating effect in an inflammatory bowel disease animal model, and therefore, the Enterococcus lactis can be very helpfully used in a health functional food, medicinal product, feed composition, or veterinary composition for regulating immune functions and preventing, alleviating, or treating an inflammatory bowel disease.
KOREA INSTITUTE OF ORIENTAL MEDICINE (Republic of Korea)
KOREA FOOD RESEARCH INSTITUTE (Republic of Korea)
Inventor
Chae, Sung Uk
Im, A-Rang
Hong, Sung Wook
Roh, Seong Woon
Lee, Ho Jae
Abstract
The present invention relates to a composition for prevention, reduction, or treatment of skin wrinkles and skin moisturization, comprising Enterococcus lactis as an effective component. More specifically, Enterococcus lactis: significantly suppresses the expression of MMP-1 and MMP-9 that is increased by UV irradiation; reduces skin thickness by softening the stratum corneum; increases the water content of the skin; reduces transdermal water loss; and increases hyaluronic acid content. Accordingly, the composition of the present invention may be utilized as: a cosmetic composition for skin wrinkle reduction or skin moisturization; a functional health food composition for skin wrinkle reduction or skin moisturization; a pharmaceutical composition for preventing or treating dry skin; a feed composition for skin wrinkle reduction and skin moisturization; and a veterinary composition for skin wrinkle reduction and skin moisturization.
A61K 8/99 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
The present invention relates to a composition for inhibiting non-fluorescent advanced glycation end products, and a use thereof. More specifically, the present invention relates to: a composition for inhibiting non-fluorescent advanced glycation end products, comprising one or more strains selected from the group consisting of Lactobacillus sp. strains, Lactococcus sp. strains, Enterococcus sp. strains, Bifidobacterium sp. strains, Bacillus sp. strains, Saccharomyces sp. strains, Pediococcus sp. strains, and Leuconostoc sp. strains; and a food composition, a pharmaceutical composition, a composition for intestinal regulation, a probiotic composition, a feed composition, and a fermented product, which have an activity of reducing non-fluorescent advanced glycation end products and comprise the composition. In addition, the present invention relates to a method for producing a non-fluorescent advanced glycation end product inhibitor and a method for inhibiting non-fluorescent advanced glycation end products.
Lactobacillus sakeiLactobacillus sakei WIKIM0109 isolated from Kimchi; and a composition containing same. The Lactobacillus sakei WIKIM0109 according to the present invention is a lactic acid bacteria having an activity of inhibiting IgG and IgG2a production in blood and an activity of inhibiting IFN-γ, IL-17, and TNF-α production, and can be used in various applications, such as for preventing and ameliorating arthritis, or improving intestinal regulation in humans or animals.
A high-speed device, for inspecting a large area of an object, which includes: a terahertz wave generation portion configured to generate a terahertz wave; a ring beam forming portion configured to form a ring beam by using the terahertz wave incident from the terahertz wave generation portion; a rotary mirror configured to reflect the ring beam formed by the ring beam forming portion while rotating to allow the ring beam to be incident on an inspection target object; and a detector configured to detect a ring beam generated from the inspection target object.
The present invention relates to novel Leuconostoc citreum WiKim0104, isolated from kimchi, and a composition comprising same, or uses of same. The present invention provides a method for preventing, alleviating, and treating inflammation, obesity, or fatty liver disease of an entity by administering novel Leuconostoc citreum WiKim0104, isolated from kimchi, or a composition comprising same. Leuconostoc citreum WiKim0104 according to the present invention has the effect of suppressing the development of fatty liver disease by suppressing fat accumulation in hepatocytes and decreasing the expression of genes which are associated with fatty liver disease and thus can be variously utilized for prevention, alleviation, and treatment of inflammation, obesity, or fatty liver disease.
A23K 10/16 - Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
A23L 29/00 - Foods or foodstuffs containing additivesPreparation or treatment thereof
A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
A61K 35/744 - Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Weissella hellenicaWeissella hellenicaWeissella hellenica WiKim0103, isolated from kimchi, or a composition comprising same. Weissella hellenica WiKim0103 according to the present invention has the effect of suppressing the development of fatty liver disease by suppressing fat accumulation in hepatocytes and decreasing the expression of genes which are associated with fatty liver disease and thus can be variously utilized for prevention, alleviation, and treatment of inflammation, obesity, or fatty liver disease.
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Leuconostoc citreum Leuconostoc citreum Leuconostoc citreum WiKim0104, isolated from kimchi, or a composition comprising same. Leuconostoc citreum WiKim0104 according to the present invention has the effect of suppressing the development of fatty liver disease by suppressing fat accumulation in hepatocytes and decreasing the expression of genes which are associated with fatty liver disease and thus can be variously utilized for prevention, alleviation, and treatment of inflammation, obesity, or fatty liver disease.
A23K 10/16 - Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
A23L 29/00 - Foods or foodstuffs containing additivesPreparation or treatment thereof
A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
A61K 35/744 - Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Lactobacillus SakeiLactobacillus SakeiLactobacillus Sakei according to the present invention can be utilized for the prevention, improvement, and treatment of mental disorders such as depression or anxiety disorders.
Lactobacillus paracasei KF00816 (accession number KCCM11998P) strain, which are all novel strains; a lysate thereof; or a culture thereof as an active ingredient. In addition, the present invention relates to a composition for intestinal regulation, a probiotic composition, a feed composition, and a fermented product, each of which comprises the novel strain of the present invention, a lysate thereof, or a culture thereof as an active ingredient.
According to one embodiment of the present invention, a terahertz wave concentrating module can comprise: a first lens for changing a terahertz wave, which is emitted while a terahertz Bessel beam penetrates an object to be inspected, so as to have a small angle; and a second lens for concentrating, on a detector, the terahertz wave having passed through the first lens.
G01N 21/3581 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using far infrared lightInvestigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using Terahertz radiation
G01V 8/10 - Detecting, e.g. by using light barriers
The present invention relates to a composition for preventing, alleviating, or treating neurodegenerative diseases, comprising Pediococcus inopinatus as an effective component. The strain of Pediococcus inopinatus according to the present invention can suppress neuroinflammation, and can also alleviate the symptoms of ataxia in animal models of Parkinson's disease, and thus can be utilized in the prevention, alleviation, and treatment of neurodegenerative diseases including Parkinson's disease.
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
79.
COMPOSITION FOR PREVENTING, ALLEVIATING OR TREATING NEURODEGENERATIVE DISEASES, COMPRISING PEDIOCOCCUS INOPINATUS
The present invention relates to a composition for preventing, alleviating, or treating neurodegenerative diseases, comprising Pediococcus inopinatus as an effective component. The strain of Pediococcus inopinatus according to the present invention can suppress neuroinflammation, and can also alleviate the symptoms of ataxia in animal models of Parkinson's disease, and thus can be utilized in the prevention, alleviation, and treatment of neurodegenerative diseases including Parkinson's disease.
A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
80.
FOOD COMPOSITION, FOR ALLEVIATING DIABETES, COMPRISING OMIJA AND BEAN JUICE, AND PREPARATION METHOD THEREOF
The present invention relates to a food composition, for alleviating diabetes, containing omija juice and bean juice as an active ingredient. The present invention exhibits excellent α-glucosidase inhibitory activity and inhibits an increase in the postcibal blood glucose level, and thus can alleviate diabetes. The food composition for alleviating diabetes can be prepared in various forms such as soybean milk, soybean milk powder, other soybean milk or soybean curd, and can be used for preparing a functional health food for controlling blood glucose or for manufacturing a common food product into a special-purpose food for diabetic patients. The food composition for alleviating diabetes of the present invention inhibits the coagulation of a soybean milk liquid, enables viscosity similar to common soybean milk and also enhances the functionality when saccharified grain is additionally comprised, and thus can appropriately be utilized as soybean milk and other soybean milk-like beverages.
COMPOSITION FOR IMPROVING GUT FLORA, OR COMPOSITION FOR ALLEVIATING, PREVENTING OR TREATING GUT INFLAMMATION, LEAKY GUT SYNDROME, OBESITY, OR METABOLIC INTESTINAL DISORDERS, COMPRISING EXTRACT OF RADISH GREENS
The present invention relates to a prebiotic composition, a composition for improving gut microbiota, and a composition for improving gut health or gut function, which comprise an extract of radish greens or a polymer fraction of radish greens as an effective component, and thus can induce propagation of beneficial bacteria in the gut to improve, prevent or treat the gut health or gut function. In addition, the compositions of the present invention have no toxicity and thus can be taken in a form of a food product. The present invention relates to a composition for alleviating, preventing, or treating obesity or metabolic disorder, and more specifically, to a composition comprising an extract of radish greens as an effective component for alleviating, preventing, or treating obesity or metabolic disorder, and a composition for enhancing intestinal immunity. The present invention relates to a composition for alleviating, preventing, or treating obesity or metabolic disorder, and more specifically, to a composition for alleviating, preventing, or treating obesity or metabolic disorder, which comprises an extract of radish greens as an effective component, and thus suppresses preadipocyte differentiation and lipid accumulation; reduces increases in body weight and body fat; lowers endotoxin, neutral fat, and total cholesterol concentrations in serum; and suppresses the expression of hormones associated with adipocyte differentiation in serum. The compositions according to the present invention not only can treat obesity, but also can alleviate, prevent, or treat obesity-induced metabolic disorders along with the treatment of obesity by enhancing immune activation, and thus are extremely useful.
The present invention relates to novel Lactobacillus sakei WIKIM30 (accession number KCCM11878P) isolated from Kimchi, and a composition comprising same as an active ingredient. Exhibiting excellent anticancer activity in animal models into which cancer cells have been transplanted and cancer cell lines, Lactobacillus sakei WIKIM30 according to the present invention can be advantageously used as a composition for treatment, prevention, or alleviation of cancer in humans or animals.
The present invention relates to a novel Weissella cibaria WIKIM28 (accession number: KCCM11879P) and a composition comprising same as an active ingredient, the Weissella cibaria WIKIM28 being separated from kimchi. The Weissella cibaria WIKIM28, according to the present invention, exhibits excellent anticancer activity in a cancer cell-transplanted animal model, and thus may be usefully employed for a composition for the use of treating, preventing or improving cancer in humans or animals.
The present invention relates to a novel Weissella cibaria WIKIM28 (accession number: KCCM11879P) and a composition comprising same as an active ingredient, the Weissella cibaria WIKIM28 being separated from kimchi. The Weissella cibaria WIKIM28, according to the present invention, exhibits excellent anticancer activity in a cancer cell-transplanted animal model, and thus may be usefully employed for a composition for the use of treating, preventing or improving cancer in humans or animals.
The present invention relates to a novel Lactobacillus fermentum WiKim0102 (Accession No. KCCM12356P) isolated from kimchi, and to a composition comprising same as an effective component. The Lactobacillus fermentum WiKim0102 according to the present invention exhibits excellent anti-cancer activities in existing animal models and animal models with human tumor cells transplanted therein, and thus can be beneficially used as a composition for use in treatment, prevention, or alleviation of cancer in humans or animals.
Lactobacillus curvatus WIKIM55 according to the present disclosure is a probiotic having activities of promoting hair growth and can be diversely applied for intestinal regulation and promotion of hair growth in humans or animals.
A23K 10/16 - Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
A23L 29/00 - Foods or foodstuffs containing additivesPreparation or treatment thereof
A23L 33/135 - Bacteria or derivatives thereof, e.g. probiotics
A61K 35/747 - Lactobacilli, e.g. L. acidophilus or L. brevis
87.
Compositions for ameliorating, preventing or treating somnipathy including phloroglucinol as active ingredient and compositions for suppressing intolerance to or alleviating side effects of agonist at benzodiazepine binding site of GABA-A receptor including phloroglucinol as active ingredient
The present invention relates to a pharmaceutical composition and a health functional food composition, which include phloroglucinol active ingredient, for preventing, treating, or ameliorating somnipathy and suppressing intolerance to, alleviating, or ameliorating side effects of an agonist at the benzodiazepine binding site of the GABA-A receptor. The pharmaceutical composition and the food composition rapidly and reliably induce and maintain sleep, prevent repeated awakenings, unalter physiological sleep architecture, are particularly devoid of residual sedative effects, which could impair daytime functioning and cognitive performance, and neither cause side effects nor intolerance to a conventional agonist at the benzodiazepine binding site of the GABA-A receptor despite long-term administration. The pharmaceutical composition uses a reduced amount of the agonist, which may increase the amount of sleep but degrade the quality of sleep to cause various side effects, to alleviate side effects of the agonist or suppress tolerance to the agonist resulting from long-term administration.
A61K 31/437 - Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
A61K 31/5025 - PyridazinesHydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
A61K 31/519 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
A61K 9/00 - Medicinal preparations characterised by special physical form
88.
COMPOSITION COMPRISING MOLOKHIA EXTRACT AS ACTIVE INGREDIENT FOR IMPROVING GUT MICROBIOME OR FOR ALLEVIATING, PREVENTING, OR TREATING INTESTINAL INFLAMMATION, LEAKY GUT SYNDROME, OBESITY, OR METABOLIC DISEASE
The present invention relates to a prebiotic composition, a composition for improving gut microorganisms, a composition for improving gut health or gut function, a composition for alleviating, preventing, or treating inflammatory bowel disease or leaky gut syndrome, or a composition for alleviating, preventing, or treating obesity or metabolic disease, which each comprise a molokhia extract or a molokhia polymer fraction as an active ingredient to induce the proliferation of beneficial intestinal bacteria and to improve, prevent, or treat gut heath or gut function. In addition, the composition comprising a molokhia extract or a molokhia polymer fraction as an active ingredient can alleviate, prevent, or treat bowel disease or leaky gut syndrome. Moreover, the composition of the present invention comprises a molokhia extract or a molokhia polymer fraction as an active ingredient that improves immunological activity as well as having anti-obesity activity, thereby not only treating obesity, but also alleviating, preventing, or treating obesity-induced metabolic diseases and as such, is very advantageous.
C12Q 1/689 - Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
90.
VECTOR EXPRESSING RECOMBINANT ANTIGEN BY USING CRISPR EDITING TECHNOLOGY, AND SIMULTANEOUS MULTIPLE INSERTION METHOD THEREFOR
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (Republic of Korea)
KOREA FOOD RESEARCH INSTITUTE (Republic of Korea)
IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY) (Republic of Korea)
KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (Republic of Korea)
Inventor
Kim, Chonsaeng
Kim, Seong Jun
Ahn, Dae Gyun
Kim, Kyun Do
Ku, Keunbon
Kim, Hae Soo
Shin, Hye Jin
Hwang, In Su
Yoon, Gun Young
Chang, Hyun Joo
Huynh, Thi Ngoc Duyen
Kim, Mihwa
Kim, Bum Tae
Bae, Sangsu
Woo, Jaesung
Abstract
Provided in the present invention is a method for simultaneously inserting multiple vectors expressing recombinant antigens in multiple locations of eukaryotic chromosomes by using a homology directed recombination method, which is a CRISPR technology. The present invention relates to a method for expressing a recombinant protein which can be used as an immunogen, by selecting a human cell line that can stably over-express an immunogen, when simultaneous insertion into two sites is performed, and then using the cells, and which can be effectively used for the development of recombinant immunogens and vaccines against various socially problematic viruses.
The present invention discloses a composition for alleviating lung diseases, such as asthma and chronic obstructive pulmonary disease, using the extracts of Paliurus ramosissimus (Lour.) Poir, Rosa davurica Pall., Picrasma quassioides, Camellia sinensis, Chrysosplenium grayanum, Reynoutria japonica, Pseudocydonia sinensis, Hydrangea serrata, and/or Euonymus alatus. The extracts of Paliurus ramosissimus (Lour.) Poir, Rosa davurica Pall., Picrasma quassioides, Camellia sinensis, Chrysosplenium grayanum, Reynoutria japonica, Pseudocydonia sinensis, Hydrangea serrata, and/or Euonymus alatus have the activities of inhibiting the netosis activation of neutrophil extracellular traps induced by phorbol myristate acetate (PMA), inhibiting the expression of IL-8, an inflammatory cytokine by CSE of NCI-H292 cells, a bronchial epithelial cell line producing mucus, and inhibiting the expression of MIP-2, an inflammatory cytokine of alveolar macrophages MH-S cells activated by CES and LPS (lipopolysaccaride). In addition, the extracts have the activities of inhibiting lung tissue damage in the mouse model of CSE and PPE induced respiratory disease, inhibiting immune cell infiltration of total cell, macrophages, lymphocytes, eosinophils, and neutrophils in BALF, and inhibiting the secretion of inflammatory cytokines and chemokines in BALF and lung tissue.
Disclosed in the present invention is a composition for alleviating asthma or chronic obstructive pulmonary disease by using a Epilobium pyrricholophum extract and the like that: inhibit NETosis induced by phorbol myristate acetate (PMA); inhibit the expression of inflammatory cytokines IL-6 and IL-8 in H292 cells, which are the bronchial epithelial cell line and are stimulated by cigarette smoke extract (CSE), porcine pancreas elastase (PPE) and ultrafine dust that is 2.5 micrometers or less in diameter (PM2.5); inhibit the expression of inflammatory cytokine MIP2 (IL-8) that are also in MH-S cells, which are mouse alveolar macrophages and are activated by CES; reduce the number of neutrophils and the like in BALF during animal model experimentation in which COPD is induced by using CES and PPE; and reduce, in BALF or lung tissues, the concentration of inflammatory cytokines such as MIP-2, TNF-α, IL-1β, IL-6, KC, MCP-1 and IFN-γ and the concentration of MDC, GM-CSF, IL-17 and the like.
According to one embodiment of the present invention, a terahertz wave concentrating module can comprise: a first lens for changing a terahertz wave, which is emitted while a terahertz Bessel beam penetrates an object to be inspected, so as to have a small angle; and a second lens for concentrating, on a detector, the terahertz wave having passed through the first lens.
G01V 8/14 - Detecting, e.g. by using light barriers using one transmitter and one receiver using reflectors
G01N 21/3581 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using far infrared lightInvestigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using Terahertz radiation
Provided is a paper-based colorimetric sensor kit for rapid, convenient, and visual in-situ diagnosis of mercury. A colorimetric sensor kit comprises a sensing material kit and a radial paper chromatography, the sensing material kit including: a circular template for rolling circle amplification (RCA); a primer that hybridizes with the template but does not when a mercury ion is bound thereto; a DNA polymerase; and a nanoparticle probe that labels the DNA coil nascent from the circular template for rolling circle amplification.
A61P 15/00 - Drugs for genital or sexual disordersContraceptives
A61K 8/99 - Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof, of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
Camellia japonicaCamellia japonica extract as an active ingredient. The composition of the present invention exhibits the effects of not only alleviating and treating generated pain but also preventing pain when administered to a subject before pain occurs. The composition of the present invention exhibits a remarkable pain relieving effect not only by intravenous injection or application to the skin but also by oral administration. The composition of the present invention having such characteristics can be applied to food.
99.
DEVICE FOR INSPECTING LARGE AREA HIGH SPEED OBJECT
The objective of the present invention is to provide a smart dosimeter coupled to a legal dosimeter, the smart dosimeter being used as if formed in one structure enabling the legal dosimeter to be attached and coupled to the smart dosimeter, detecting whether the legal dosimeter is worn by means of a sensor in the smart dosimeter, and enabling an instantaneous radiation exposure value to be checked in real time in order to provide help for enabling a safer operation to be performed. The smart dosimeter comprises: a motion detection unit for detecting a motion; a legal dosimeter detection unit for checking whether the legal dosimeter is coupled and fixed to a coupling part included in the smart dosimeter; a wearing-checking unit for checking whether a radiation worker is wearing the legal dosimeter, on the basis of motion information detected by the motion detection unit and coupling and fixation information checked by the legal dosimeter detection unit; a G-M detection unit for measuring and detecting, in real time, the exposure dose of the worker; and a data communication unit for transmitting the exposure dose detected by the G-M detection unit to a management server and receiving warning situation information from the management server.
G01N 21/3581 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using far infrared lightInvestigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light using Terahertz radiation
in vivoex vivoex vivo. Also, miquelianin was found to have the effect of producing IgE and preventing T cell proliferation. Therefore, the composition according to the present invention is expected to find useful applications in the development of a therapeutic agent, a health functional food, and a cosmetic product for prevention, alleviation, or treatment of Th2-mediated immune diseases.
A61K 31/7048 - Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin
A23L 33/10 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives
patents
