Disclosed is a curable composition for dental use, which can be cured into a product having both excellent light-diffusing properties and excellent transparency and also having excellent mechanical strength and excellent gloss when polished, and which can be formed into a paste having good handling properties. The curable composition for dental use comprises (A) a polymerizable monomer which can be polymerized into a product having a refractive index of 1.52 to 1.58, (B) inorganic particles having a refractive index of 1.43 to 1.50, and (C) inorganic particles having a refractive index of 1.52 to 1.58, wherein the inorganic particles (B) are aggregates of inorganic microparticles having an average primary particle diameter of 2 to 50 nm and the inorganic particles (B) are contained in an amount of 0.1 to 10 wt%.
Disclosed is a polymerizable composition for dental applications, which is suitable as an implant temporary cement and a mobile tooth fixing material. The polymerizable composition for dental applications comprises: an alkyl styrene block copolymer (a) that comprises a polymer block (A) mainly composed of a styrene unit having a C1-8 alkyl group and a polymer block (B) mainly composed of at least one monomer unit selected from the group consisting of a conjugated diene compound unit, a unit produced by adding hydrogen to a conjugated diene compound unit, and an isobutylene unit; a polymerizable monomer (b); and a polymerization initiator (c).
A dentine calcification agent which comprises tetracalcium phosphate particles (A) and an alkali metal phosphate (B), characterized in that the content of the tetracalcium phosphate particles (A) is 1 to 80 parts by weight per 100 parts by weight of the total dentine calcification agent, and the content of the alkali metal phosphate (B) is 1 to 100 parts by weight per 100 parts by weight of the tetracalcium phosphate particles (A). Thus, a dentine calcification agent, by which a dense HAp layer can be formed on the surface of the dentine and HAp can be deposited even in deep parts of dentinal tubules to thereby block the dentinal tubules, is provided.
A tooth calcification agent which comprises tetracalcium phosphate particles (A) and an alkali metal phosphate (B), characterized in that the content of the tetracalcium phosphate particles (A) is 1 to 80 parts by weight per 100 parts by weight of the total tooth calcification agent, and the content of the alkali metal phosphate (B) is 0.5 to 50 parts by weight per 100 parts by weight of the tetracalcium phosphate particles (A). Thus, a tooth calcification agent having an excellent calcification effect, in particular an excellent calcification effect on the surface of the enamel, is provided.
A redox-curing type composition which, when penetrates a wet substance such as tooth substance (dentin), can be cured at a speed accelerated by the water contained in the wet substance, and which exhibits a bond strength higher than that of a conventional composition, and excellent storage stability. The redox-curing type composition comprises (a) a polymerizable monomer having an acid group, (b) a polymerizable monomer free from acid groups, (c) a powdery inorganic peroxide having a mean particle diameter of 0.01 to 50μm, (d) an amine-based reducing agent, and (e) a polymerization accelerator, wherein the amine-based reducing agent (d) consists of (d-1) an aromatic amine and (d-2) an aliphatic amine at a (d-1)/(d-2) weight ratio of 5 : 1 to 1 : 50.
A polymerizable composition which exerts high curability even when an LED irradiation device as well as a halogen lamp type irradiation device is used and which rarely discolors even when stored for a long period. When used as dental material, the polymerizable composition attains high bond strength between a cured body of the composition and tooth substance. The polyerizable composition comprises both a photopolymerization initiator composition and a polymerizable monomer (D). The photopolymeization initiator composition comprises both a photopolymerization initiator component consisting only of a bisacylphosphine oxide (A) and an α-diketone (B), and a tertiary amine (C). The (A)/(B) weight ratio of the bisacylphosphine oxide (A) to the α-diketone (B) is 1:9 to 9:1 and the (D)/(C) weight ratio of the polymerizable monomer (D) to the tertiary amine (C) is 100:0.5 to 100:10.
Disclosed is a dental post that affords increased resistance in the extraction direction, and that can reduce the risk of root fracture. A dental post (10) constituted of a fiber-reinforced composite material comprises a distal insertion portion (14) for insertion in a dental canal, and a support portion (12) adjacent to the distal insertion portion (14). At least one recessed portion (16) is formed in the dental post (10) in only the section thereof within 6mm of the extremity (18) of the distal insertion portion (14) on the opposite side to the support portion (12).
Disclosed is a dental composition containing a polymerizable monomer component (A) and an amorphous filler (B) which contains silica fine particles and an oxide covering the surfaces of the silica fine particles and containing a zirconium atom, a silicon atom and an oxygen atom, and has an average particle diameter of 1-20 μm. The filler (B) is contained in an amount of 20-500 parts by weight per 100 parts by weight of the polymerizable monomer component (A). The dental composition has a viscosity within the range of 10-800 Pa·s. The filler (B) preferably contains spherical particles, and the ratio of the spherical particles in the filler (B) is preferably not less than 60%.
Provided is a dental composition which has good operability as a paste and of which the cured form has excellent light-dispersing properties and transparency as well as excellent mechanical strength and polishing properties. The dental composition contains (A) polymerizable monomer and (B) amorphous powder of mean particle size from 1 to 20 μm which includes fine silica-based particles and oxide containing zirconium atoms, silicon atoms and oxygen atoms coated on the surface of said fine silica-based particles. The difference between the refractive indices of the cured form of said polymerizable monomer (A) and said amorphous powder (B) is from 0.005 to 0.03.
Disclosed is a dental composition containing a polymerizable monomer (A), an amorphous filler (B) which contains silica fine particles and an oxide covering the surfaces of the silica fine particles and containing a zirconium atom, a silicon atom and an oxygen atom, and has an average particle diameter of 1-20 μm, and inorganic particles (C) having an average particle diameter of 0.1-1.0 μm. It is preferable that 50-400 parts by weight of the filler (B) and 100-400 parts by weight of the inorganic particles (C) are contained per 100 parts by weight of the polymerizable monomer (A).
A calcium phosphate composition comprising calcium phosphate particles (A) and a sulfonic acid salt (B), characterized in that the content of the sulfonic acid salt (B) is 0.5 to 20 parts by weight per 100 parts by weight of the particles (A). When used in a clinical site or the like, the composition exhibits a hardening time (a time necessary for the composition to harden after the addition of a liquid agent) within an appropriate range, and can form a hardened mass which has high mechanical strengths and attain excellent peripheral sealing.
National University Corporation Okayama University (Japan)
Inventor
Yoshida, Yasuhiro
Namba, Naoko
Nagaoka, Noriyuki
Takashiba, Shogo
Suzuki, Kazuomi
Nojiri, Yamato
Ishino, Hiroshige
Sekiguchi, Takahiro
Okada, Koichi
Abstract
A dental oral composition which comprises (a) a phosphorylated sugar, (b) a polyphosphoric acid and/or a salt thereof, and (c) a cationic bactericide, wherein the proportion of the total content of the phosphorylated sugar (a) and the polyphosphoric acid and/or salt thereof (b) to the content of the cationic bactericide (c) [{(a)+(b)}/(c)] is 0.05-20 (by weight). This dental oral composition is suitable for use, e.g., in dentifrices such as a tooth paste, tooth powder, and tooth liquid, dental rinses, troches, tablets, creams, ointments, patches, mouth sprays, coating materials for tooth surfaces and dental prosthetic appliances, hypersensitivity inhibitors, periodontosis remedies for application to periodontal pockets, wet tissues for oral care, mouth refreshments, chewing gum, or oral detergents such as mouthwashes.
Disclosed is a cement for dental applications, which comprises a first preparation and a second preparation, wherein each of the first and second preparations comprises a polymerizable monomer (a) and a filler (b), wherein the first preparation and/or the second preparation further contains a photopolymerization initiator (c), and wherein at least one of the first and second preparations contains an oxidizing agent (f) which is a component of a redox polymerization initiator comprising the oxidizing agent (f) and a reducing agent (g) (the redox polymerization initiator is used as a chemical polymerization initiator (d)) and the other contains the reducing agent (g) which is the other component of the redox polymerization initiator. The photopolymerization initiator (c) comprises an α-diketone. The total content of the photopolymerization initiator (c) is 0.010 to 0.100 part by weight relative to the total amount (100 parts by weight) of the polymerizable monomer (a). The total content of the chemical polymerization initiator (d) is 0.001 t0 20 parts by weight relative to the total amount (100 parts by weight) of the polymerizable monomer (a). When the cement is photo-cured, the compression elasticity of a cured product is 100 to 400 MPa immediately after the photo-curing and becomes 500 MPa or more 24 hours after the photo-curing. The cement for dental applications can be used suitably for the bonding between a tooth structure and a crown prosthesis or the like in the field of dental care.
A double filtration blood purification apparatus with which priming can be performed while preventing any bubble generation in the respective separation membranes of a blood component separator and a plasma component separator; and a method of priming therefor. A cleansing liquid introduction circuit (19) being a circuit dedicated to feed a cleansing liquid (P) from a cleansing liquid supply source (57) to a plasma component separator (3) is provided. The cleansing liquid introduction circuit (19) is furnished with a dedicated third pump. When the third pump is actuated to make normal rotation and a first pump to make reverse rotation by a controller (50), satisfactory pressure would be applied to the cleansing liquid (P) by the third pump to thereby attain introduction in the plasma component separator (3).
A blood purification apparatus and method of confirming any circuit continuity failure thereof that would ensure unfailing confirmation as to whether or not the connection of circuit constituent elements to circuit is appropriate. A return blood valve (19) disposed in a return blood circuit (9) for returning blood having been treated by a first blood treating unit (1) into the body of a patient is closed so as to realize a blocked state with respect to a blood circuit including a blood introduction circuit (8), the return blood circuit (9) and a delivery circuit (10) for delivering unwanted blood components from the first blood treating unit (1). A first pump (4) disposed in the delivery circuit (10) is normally rotated, and an air pump (70) connected to the blood introduction circuit (8) and the return blood circuit (9) is reversely rotated, so that air is expelled from the blood circuit to thereby generate a negative pressure in the blood circuit and the first blood treating unit (1). At the point of time when the negative pressure reaches a first preset pressure, connection between the blood circuit and the first blood treating unit (1) is confirmed.
A polymerizable composition that in application to dental material, realizes excellent adhesion with tooth structure (especially, dentin); and a polymerizable monomer as a component thereof. There is provided compound (A) being any of compounds of the formula: (1) (in the formula, G is a polymerizable group; m is an integer of 2 or greater; and n is an integer of 1 or greater, provided that the arrangement sequence of unit having m polymerizable groups and unit having n hydroxyls is arbitrary), and provided a polymerizable composition comprising the compound (A).
Disclosed is a dental composition containing a polymerizable monomer (a) having an aromatic ring and a hydroxy group, a polymerizable monomer (b) having an aromatic ring but not having a hydroxy group, and a polymerizable monomer (c) other than the polymerizable monomers (a) and (b). The contents of the polymerizable monomers (a), (b) and (c) relative to the total polymerizable monomers are 10-30% by weight, 50-70% by weight and 10-30% by weight, respectively. This dental composition is suitably used as a substitute for a part or the whole of a natural tooth in the field of dentistry.
Disclosed is a curable composition for dental purposes comprising: a polymerizable monomer; an amorphous inorganic particle (A) whose surface is treated with a silane coupling agent (a) represented by the formula (I): (I) [wherein R1 represents a hydrogen atom or a methyl group; R2 represents a hydrolyzable group; R3 represents a hydrocarbon group having 1 to 6 carbon atoms; X represents an oxygen or sulfur atom; p represents an integer of 2 or 3; and q represents an integer of 8 to 13] and which has an average particle diameter of 1.0 to 5.0 &mgr;m; and an amorphous and/or spherical or approximately spherical inorganic particle (B) whose surface is treated with a silane coupling agent (b) represented by the same formula as the formula (I) for the silane coupling agent (a) except that q in the formula represents an integer of 1 to 6 and which has an average particle diameter of 0.01 to 0.10 &mgr;m, wherein the inorganic particle (A) and the inorganic particle (B) are contained at ratios of 85 to 98 wt% and 2 to 15 wt%, respectively, relative to the total amount of inorganic particles. The curable composition for dental purposes can be used suitably as an alternative to a part or the entire of a natural tooth in the dental field.
Disclosed is a multi-part redox-curing composition which comprises: a first part prepared by dissolving at least an oxidizing agent (b) in a first radical-polymerizable monomer comprising a radical-polymerizable monomer (a) having an acidic group and/or a hydrophilic group; and a second part prepared by dispersing at least an aromatic sulfinate salt (d) in a second radical-polymerizable monomer comprising a radical-polymerizable monomer (c) having no acidic group or hydrophilic group. The redox-curing-type composition can secure sufficient time for the adhesion procedure and can exhibit excellent adhesion strength at the initial stage of the adhesion and over a long period of time thereafter against the outer part of a moist material such as a tooth bud and a bone or a tooth crown restoration material such as a metal and a ceramic material.
Disclosed is a composition which exhibits excellent adhesion to tooth structure (especially to dentin) when applied to a dental material. Specifically disclosed is a composition containing a polymerizable monomer (A) having an unconjugated carbon chain wherein four or more carbon atoms are continuously bonded, two or more polymerizable groups and two or more hydroxy groups, and a bisacylphosphine oxide (B) represented by the following formula (1). (In the formula, the symbols are as defined in the description.)
It is intended to provide a polymerizable composition which exerts an excellent adhesiveness to a tooth tissue (in particular, the dentinal matrix) when employed as a dental material, and a polymerizable monomer which is a component of the same. Namely, a polymerizable monomer (A) which is a compound having two or more polymerizable groups and shows a retention time of from 7 minutes to 30 minutes in high-performance liquid chromatography (HPLC) measurement conducted under the following conditions (column: being 3.9 mm in inner diameter and 300 mm in height and packed with a C18 packing agent having been ground to give an average grain sizeof 10 騜m and having a pore size of 125 Å, eluent: a solvent mixture of methanol/water (3/7), flow rate: 1.0 mL/min, measurement temperature: 50°C, sample injection: 10 騜L, dead volume from the sample inlet to the detection point: 87 騜L); and a composition containing the same.
Disclosed is a composition which is suitable for a dental composition. Specifically disclosed is a composition containing a polymerizable monomer (A) having a non-conjugated carbon chain wherein four or more carbon atoms are continuously bonded, two or more polymerizable groups and two or more hydroxy groups, and water (B). The composition contains 6-2000 parts by weight of water (B) per 100 parts by weight of the polymerizable monomer component in total. When an adequate ingredient is added to this composition, the resulting composition is suitably used as a dental material such as a primer, a bonding material, a composite resin or a cement.
Disclosed is a composition which is suitable for a dental composition. Specifically disclosed is a composition containing a polymerizable monomer (A) having a non-conjugated carbon chain wherein four or more carbon atoms are continuously bonded, two or more polymerizable groups and two or more hydroxy groups, and a polymerizable monomer (B) having one polymerizable group and one or more hydroxy groups. When an adequate ingredient is added to this composition, the resulting composition is suitably used as a dental material such as a primer, a bonding material, a composite resin or a cement.
Disclosed is a composition excellent in thermal stability and environmental light stability, which exhibits excellent adhesion to tooth structure (especially to dentin) when applied to a dental material. Specifically disclosed is a composition containing a polymerizable monomer (A) having an unconjugated carbon chain wherein four or more carbon atoms are continuously bonded, two or more polymerizable groups and two or more hydroxy groups, and a polymerization inhibitor (B). This composition contains 0.0010-10 parts by mass of the polymerization inhibitor (B) per 100 parts by mass of the total amount of the polymerizable monomer component.
Disclosed is a novel compound (I) represented by the general formula (1) which has a polymerizable group, a carboxyl group and a phosphate group and can be suitable used in a dental composition. Also disclosed is a process for producing a polymerizable amide, which can allow the condensation reaction between a carboxylic acid and an amine to proceed readily and is highly safe. (1) wherein R1, R2 and R3 independently represent a hydrogen atom or a hydrocarbon group having 1 to 20 carbon atoms which may have a substituent; (A) and (B) independently represent an arbitrary constituent unit; m represents an integer of 1to 3; n represents an integer of 1 to 3; R4 represents an organic group having 1 to 40 carbon atoms which may have a substituent; R5 represents a hydrocarbon group having 1 to 20 carbon atoms which may have a substituent; and R6 and R7 independently represent a hydrogen atom, a hydrocarbon group having 1 to 20 carbon atoms which may have a substituent or a metal atom.
A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
C07C 231/02 - Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
C07C 233/47 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
Disclosed is a method for easily producing a crosslinkable hydroxyl group-containing (meth)acrylate-like compound at low cost by using a highly safe raw material. Specifically disclosed is a method for producing a hydrophilic monomer represented by the formula (4) below, which comprises a step for reacting a compound represented by the formula (1) below with a compound represented by the formula (2) below. (In the formulae, the symbols are as defined in the description.)
C07C 67/08 - Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
C07C 67/14 - Preparation of carboxylic acid esters from carboxylic acid halides
NATIONAL UNIVERSITY CORPORATION OKAYAMA UNIVERSITY (Japan)
KURARAY MEDICAL INC. (Japan)
Inventor
Yoshida, Yasuhiro
Nanba, Naoko
Nagaoka, Noriyuki
Matsuura, Kaori
Takashiba, Shogo
Suzuki, Kazuomi
Ishino, Hiroshige
Sekiguchi, Takahiro
Okada, Koichi
Abstract
An oral composition for dental purposes, comprising a phosphorylated sugar (a), a cationic disinfectant (b) and a solvent (c). The oral composition can prevent the adhesion of an oral bacterium to the surface of a tooth for a long time. Therefore, the oral composition can be suitably used as a mouth wash, a tooth paste, a mouth-rinsing solution, a mouth spray, a coating agent or patch which is intended to be applied to the surface of a tooth or a dental prosthesis, a hyperesthesia-preventing agent, a therapeutic agent for periodontal disease which is intended to be applied to a periodontal pocket, and the like.
A dispenser in which an operation load of a plunger is stable and the contents of the dispenser do not leak out after pressing operation is stopped. The dispenser has a syringe body (1) having a space in which the contents are placed and also having a pouring nozzle attached to the forward end of the syringe body, the plunger (2) slid, by pressing force applied to it, in the syringe body (1) to pour out the contents in the space (m) from the tip of the pouring nozzle, and an O-ring (3) placed in an annular groove (2c) formed in a forward end section of the plunger (2) and slidable on the inner wall surface of the syringe body (1). The annular groove (2c) is formed as a partitioned recess having a bottom wall flat over it. A projection or a groove (4) is formed in a side wall of the annular groove (2c), and the projection or the groove (4) guides back suction of the contents by causing, by restoring force of the O-ring (3), the plunger (2) to slide in the direction opposite to the push-in direction of the plunger (2).
B05C 5/00 - Apparatus in which liquid or other fluent material is projected, poured or allowed to flow on to the surface of the work
A61C 5/04 - Implements for filling natural teeth; Methods or instruments for medication of tooth nerve channels
B05C 17/005 - Hand tools or apparatus using hand-held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material through an outlet orifice by pressure
29.
CALCIUM PHOSPHATE COMPOSITION AND PROCESS FOR PRODUCING THE SAME
A calcium phosphate composition which comprises tetracalcium phosphate particles (A), calcium hydrogen phosphate particles (B), and at least one kind of inorganic particles (C) selected between silica particles and titania particles, characterized in that the proportion of (A) to (B), (A/B), is from 45/55 to 55/45 by mole, the inorganic particles (C) have an average particle diameter of 0.002-0.5 µm, and the inorganic particles (C) are contained in an amount of 0.1-20 parts by weight per 100 parts by weight of the sum of the ingredients (A) and (B). When the calcium phosphate composition is used as, e.g., a material for bone repair, it enables a bone having high mechanical strength to grow and attains a high degree of bone replacement.
An adhesive composition comprising a polymerizable monomer (a) containing a phosphoric acid group and further containing a fluorocarbon group and a solvent (b), the polymerizable monomer (a) represented by the formula: wherein R is a hydrogen atom or methyl; and each of n, p and q is a natural number and satisfies the relationships 2≤n≤10, p+q ≤ n and p+q+n ≤ 13. This adhesive composition realizes excellent adhesion force and bond durability enabling suitable application to fields, such as those of medical treatment, electronic industry, precision machinery industry and jewelry industry, and is one exhibiting a low fluctuation of adhesion force. As the adhesive composition exhibits excellent bond durability and discoloration resistance to dental restoration materials, such as those of ceramic, composite resin hardened material, porcelain and metals, especially new dental restoration materials, such as those of hybrid ceramics and metal oxide high-strength ceramic, the adhesive composition finds suitable application in dental fields.
A61K 6/083 - Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
C08F 30/02 - Homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing phosphorus
31.
FLUORINE ION-RELEASABLE COMPOSITION FOR DENTAL PURPOSES
A fluorine ion-releasable composition for dental purposes comprising (a) an inorganic powder, (b) a fluorine ion-releasable substance, (c) a polymerizable monomer and (d) a polymerization initiator, the inorganic powder (a) comprising a complex particle comprising a base particle composed of an inorganic substance and a layer composed of a polysiloxane formed on the surface of the base particle, and the fluorine ion-releasable substance (b) comprising at least one component selected from the group consisting of ammonium fluoride, ammonium hydrogenfluoride, a metal fluoride, a polymer having a vinyl monomer bearing an acid fluoride group as the constitutional unit and a fluorine-containing phosphazene monomer. The composition can provide a high anti-cariogenicity to tooth structure for a prolonged period of time by the action of a fluorine ion released from the composition in a controlled manner. Therefore, the composition can be used suitably as a dental adhesive, a dental filler, a resin for core build-up for dental purposes, a pit and fissure sealant, a dental coating material (manicure), a dental cement or the like.
patents