Disclosed is a prophylactic or therapeutic drug for Parkinson's disease, which comprises a trisulfide compound and is characterized by being administered in combination with a drug that is used for a dopamine supplementation therapy.
Disclosed is a compound represented by formula (1) or a salt thereof: [Formula 1] [In the formula, R1is a group represented by formula (2), a group represented by formula (3), a group represented by formula (4), or a group represented by formula (5)] [Formula 2] [In the formula, R2and R3each independently are a C1 to 4 alkylene group and * represents a bond] [Formula 3] [In the formula, R4and R5each independently represent a hydrogen atom or an optionally substituted C1 to 4 alkyl group, R4and R5 may form a ring together with the atoms to which they are bonded, and * represents a bond] [Formula 4] [In the formula, * represents a bond] [Formula 5] [In the formula, * represents a bond].
C07D 341/00 - Heterocyclic compounds containing rings having three or more sulfur atoms as the only ring hetero atoms
A61K 31/385 - Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
Disclosed is a compound represented by formula (1) or a salt thereof. (In the formula: R10is a hydrogen atom or the like; R11 is a hydrogen atom or the like; and h and i are each independently 0 or 1.)
The present invention exhibits strong preventive effects and/or therapeutic effects with regard to inflammatory disorders and/or pain disorders by combining and administering glutathione trisulfide or a pharmaceutically-acceptable salt thereof and a non-steroidal anti-inflammatory drug or a pharmaceutically acceptable salt thereof.
The present invention provides a method for separating a compound represented by Formula (1) or (2) [in the formula, P1 is a hydrogen atom or a protective group of a hydroxyl group, R1 is a linear or branched C1-6 alkyl group that may be substituted with a phenyl group, A is an alkenylene group, and R2 is a hydroxyl group, a C1-3 alkoxy group, a mono(C1-3 alkyl)amino group, or a di(C1-3 alkyl)amino group] from a geometrical isomer thereof, in which the geometrical isomer is a geometrical isomer in a double bond included in A, the method including processing a mixture containing the compound and the geometrical isomer thereof by a chromatographic method using an acidic functional group-modified silica gel as a stationary phase.
The present invention provides a method for separating a compound represented by Formula (1) or (2) [in the formula, P1 is a hydrogen atom or a protective group of a hydroxyl group, R1 is a linear or branched C1-6 alkyl group that may be substituted with a phenyl group, A is an alkenylene group, and R2 is a hydroxyl group, a C1-3 alkoxy group, a mono(C1-3 alkyl)amino group, or a di(C1-3 alkyl)amino group] from a geometrical isomer thereof, in which the geometrical isomer is a geometrical isomer in a double bond included in A, the method including processing a mixture containing the compound and the geometrical isomer thereof by a chromatographic method using an acidic functional group-modified silica gel as a stationary phase.
C07C 405/00 - Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins
A compound represented by Formula (1) or (3).
A compound represented by Formula (1) or (3).
A compound represented by Formula (1) or (3).
wherein R1 and R2 are each independently a hydrogen atom; a C1-6 alkyl group optionally having one or more substituents selected from the group consisting of a carboxy group and —OR5; a C2-6 alkyl group having one or more substituents selected from the group consisting of —NR6R7 and —N+R9R10R11; or —(CH2CH2O)nR8;
A compound represented by Formula (1) or (3).
wherein R1 and R2 are each independently a hydrogen atom; a C1-6 alkyl group optionally having one or more substituents selected from the group consisting of a carboxy group and —OR5; a C2-6 alkyl group having one or more substituents selected from the group consisting of —NR6R7 and —N+R9R10R11; or —(CH2CH2O)nR8;
A compound represented by Formula (1) or (3).
wherein R1 and R2 are each independently a hydrogen atom; a C1-6 alkyl group optionally having one or more substituents selected from the group consisting of a carboxy group and —OR5; a C2-6 alkyl group having one or more substituents selected from the group consisting of —NR6R7 and —N+R9R10R11; or —(CH2CH2O)nR8;
wherein R4 is a C1-6 alkyl group having one or more substituents selected from the group consisting of a carboxy group and —OR5; a C2-6 alkyl group having one or more substituents selected from the group consisting of —NR6R7 and —N+R9R10R11, or —(CH2CH2O)nR8;
wherein R5, R6, R7, R8, R9, R10 and R11 are each independently a hydrogen atom or a C1-3 alkyl group; and n is an integer of 2 to 5.
The present invention provides a polysaccharide which has a degree of polymerisation of 16-40 and is composed only of galactose or composed only of galactose and 1-3 molecules of arabinose, the saccharide units of said polysaccharide being bonded in an unbranched chain.
C07C 213/04 - Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reaction of ammonia or amines with olefin oxides or halohydrins
C07C 215/44 - Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton bound to carbon atoms of the same ring or condensed ring system
C07D 215/22 - Oxygen atoms attached in position 2 or 4
C07D 307/22 - Nitrogen atoms not forming part of a nitro radical
Disclosed is a method for producing a trisulfide compound or a selenotrisulfide compound. This production method includes: a step for oxidizing a disulfide compound with an oxidizing agent to obtain a sulfoxide compound; and a step for reacting the sulfoxide compound that has been obtained with a source of sulfur or a source of selenium to obtain a trisulfide compound or a selenotrisulfide compound.
C07C 319/24 - Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides by reactions involving the formation of sulfur-to-sulfur bonds
C07C 323/59 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
C07C 323/60 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
C07D 341/00 - Heterocyclic compounds containing rings having three or more sulfur atoms as the only ring hetero atoms
A prostaglandin production method according to the present invention comprises reacting an unsaturated fatty acid with cyclooxygenase in the presence of a reducing agent. According to the present invention, it is possible to produce prostaglandins at a high yield.
C12P 31/00 - Preparation of compounds containing a five-membered ring having two side-chains in ortho position to each other, and having at least one oxygen atom directly bound to the ring in ortho position to one of the side-chains, one side-chain containing, not directly bound to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having at least one oxygen atom bound in gamma-position to the ring, e.g. prostaglandins
12.
PROPHYLACTIC OR THERAPEUTIC DRUG FOR PARKINSON'S DISEASE
Disclosed is a prophylactic or therapeutic drug for Parkinson's disease, which comprises a trisulfide compound and is characterized by being administered in combination with a drug that is used for a dopamine supplementation therapy.
The present invention exhibits strong preventive effects and/or therapeutic effects with regard to inflammatory disorders and/or pain disorders by combining and administering glutathione trisulfide or a pharmaceutically-acceptable salt thereof and a non-steroidal anti-inflammatory drug or a pharmaceutically acceptable salt thereof.
The present invention provides a method for separating a compound represented by formula (1) or (2) (wherein P1is a hydrogen atom or a hydroxyl-protecting group, R11-61-6 alkyl group optionally substituted by a phenyl group, A is an alkenylene group, and R21-31-31-31-3 alkyl)amino group) from a geometrical isomer therefor, the geometrical isomer being one with respect to the double bond contained in A, the method comprising treating a mixture including the compound and the geometrical isomer by chromatography using, as a stationary phase, silica gel modified with an acidic functional group.
C07C 405/00 - Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins
The present invention provides a method for producing a compound represented by Formula (1a), (1b), or (1c), comprising a step of reducing a compound represented by Formula (3) in the presence of a metal complex represented by Formula (5), an inorganic base, and a solvent under a hydrogen atmosphere to obtain a compound represented by Formula (4). In the formula, Ar1 is an aryl group, each Are is independently a phenyl group or the like, W is a biphenyl group or the like, Z is an ethylene group that is substituted with a phenyl group or the like, and L is a chlorine atom or if Z has a phenyl group or a C1-3 alkoxyphenyl group, L is one of carbon atoms constituting the phenyl group or the C1-3 alkoxyphenyl group.
The present invention provides a method for producing a compound represented by Formula (1a), (1b), or (1c), comprising a step of reducing a compound represented by Formula (3) in the presence of a metal complex represented by Formula (5), an inorganic base, and a solvent under a hydrogen atmosphere to obtain a compound represented by Formula (4). In the formula, Ar1 is an aryl group, each Are is independently a phenyl group or the like, W is a biphenyl group or the like, Z is an ethylene group that is substituted with a phenyl group or the like, and L is a chlorine atom or if Z has a phenyl group or a C1-3 alkoxyphenyl group, L is one of carbon atoms constituting the phenyl group or the C1-3 alkoxyphenyl group.
C07C 405/00 - Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins
C07D 307/935 - Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
A compound represented by formula (1) or (3). [Compound 1] [In the formula, R1and R2each independently are a hydrogen atom; a C1-6 alkyl group having one or more substituents selected from the group consisting of a carboxy group and -OR5; a C2-6 alkyl group having one or more substituents selected from the group consisting of -NR6R7and -N+R9R10R1122nnR8, R5, R6, R7, R8, R9, R10, and R11each independently are a hydrogen atom or a C1-3 alkyl group, and n is an integer of 2-5.] [Compound 2] [In the formula, R4represents a C1-6 alkyl group having one or more substituents selected from the group consisting of a carboxy group and -OR5; a C2-6 alkyl group having one or more substituents selected from the group consisting of -NR6R7and -N+R9R10R1122nnR8, and R5-R11 and n are the same as above.]
C07D 341/00 - Heterocyclic compounds containing rings having three or more sulfur atoms as the only ring hetero atoms
A61K 31/385 - Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
A61K 47/69 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
Disclosed is a method for producing a trisulfide compound or a selenotrisulfide compound. This production method includes: a step for oxidizing a disulfide compound with an oxidizing agent to obtain a sulfoxide compound; and a step for reacting the sulfoxide compound that has been obtained with a source of sulfur or a source of selenium to obtain a trisulfide compound or a selenotrisulfide compound.
C07C 319/24 - Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides by reactions involving the formation of sulfur-to-sulfur bonds
C07C 323/58 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
C07C 323/59 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
C07C 323/60 - Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
C07D 341/00 - Heterocyclic compounds containing rings having three or more sulfur atoms as the only ring hetero atoms
The prostaglandin production method according to the present invention comprises a step for causing a reaction between a cyclooxygenase and an unsaturated fatty acid in the presence of a reducing agent. According to the present invention, it is possible to produce prostaglandin in high yields.
C12P 31/00 - Preparation of compounds containing a five-membered ring having two side-chains in ortho position to each other, and having at least one oxygen atom directly bound to the ring in ortho position to one of the side-chains, one side-chain containing, not directly bound to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having at least one oxygen atom bound in gamma-position to the ring, e.g. prostaglandins
The present invention provides a method for producing a compound represented by formula (1a), (1b) or (1c), the method including a step in which a compound represented by formula (3) is reduced to obtain a compound represented by formula (4) in the presence of a metal complex represented by formula (5), an inorganic base, and a solvent and under the hydrogen atmosphere. [In the formulae, Ar1 is an aryl group, each Ar2 is independently a phenyl group or the like, W is a biphenyl group or the like, Z is an ethylene group substituted by a phenyl group or the like, L is a chlorine atom or, if Z has a phenyl group or a C1-3 alkoxyphenyl group, one of the carbon atoms constituting the phenyl group or the C1-3 alkoxyphenyl group.]
C07D 307/935 - Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
C07C 29/145 - Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen-containing functional group of C=O containing groups, e.g. —COOH of ketones with hydrogen or hydrogen-containing gases
C07C 405/00 - Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins
The present invention provides a method for producing a compound represented by formula (1a), (1b) or (1c), the method including a step in which a compound represented by formula (3) is reduced to obtain a compound represented by formula (4) in the presence of a metal complex represented by formula (5), an inorganic base, and a solvent and under the hydrogen atmosphere. [In the formulae, Ar1is an aryl group, each Ar21-31-31-3 alkoxyphenyl group.]
C07C 405/00 - Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins
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Chemicals; chemical reagents other than for medical or
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