Abstract

Oral care composition comprising: - a cellulosic polymer, - o-cymen-5-ol, - from 0.05 wt% to 0.5 wt% of chlorhexidine or salts thereof expressed as chlorhexidine free base, and - water in an amount of at least 60 wt%. Said composition is for use in the treatment and/or prevention of dental plaque formation, caries formation, calculus formation, halitosis, gingivitis, periodontitis, peri-implant mucositis and/or periimplantitis.

IPC Classes  ?

• A61Q 11/00 - Preparations for care of the teeth, of the oral cavity or of dentures, e.g. dentifrices or toothpastesMouth rinses
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 8/73 - Polysaccharides
• A61K 8/58 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur or phosphorus
• A61K 8/34 - Alcohols
• A61K 8/60 - SugarsDerivatives thereof
• A61K 8/365 - Hydroxycarboxylic acidsKetocarboxylic acids
• A61K 8/92 - Oils, fats or waxesDerivatives thereof, e.g. hydrogenation products
• A61K 8/02 - Cosmetics or similar toiletry preparations characterised by special physical form
• A61K 8/04 - DispersionsEmulsions
• A61K 47/10 - AlcoholsPhenolsSalts thereof, e.g. glycerolPolyethylene glycols [PEG]PoloxamersPEG/POE alkyl ethers
• A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
• A61K 47/24 - Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61K 47/38 - CelluloseDerivatives thereof
• A61K 47/44 - Oils, fats or waxes according to two or more groups of Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
• A61P 1/02 - Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis

Abstract

The present invention relates to oral care composition comprising a zinc salt having a solubility in water higher than 3.0·104 mg/L at 25° C., an isopropylmethylphenol compound, a glycyrrhizin derivative and water, as well as to their use in oral care, in particular for the treatment and/or prevention of dental plaque formation, caries formation, calculus formation, halitosis, gingivitis, periodontitis, peri-implant mucositis and/or periimplantitis.

IPC Classes  ?

• A61K 8/27 - ZincCompounds thereof
• A61K 8/34 - Alcohols
• A61K 8/60 - SugarsDerivatives thereof
• A61Q 11/00 - Preparations for care of the teeth, of the oral cavity or of dentures, e.g. dentifrices or toothpastesMouth rinses

Abstract

The present invention relates to oral care composition comprising o-cymen-5-ol, dipotassium glycyrrhizinate, 4-hydroxyacetophenone and water, as well as to their use in oral care, in particular for the treatment and/or prevention of dental plaque formation, caries formation, calculus formation, halitosis, gingivitis, periodontitis, peri-implant mucositis and/or periimplantitis.

IPC Classes  ?

• A61K 8/34 - Alcohols
• A61K 8/35 - Ketones, e.g. quinones, benzophenone
• A61K 8/60 - SugarsDerivatives thereof
• A61K 8/73 - Polysaccharides
• A61Q 11/00 - Preparations for care of the teeth, of the oral cavity or of dentures, e.g. dentifrices or toothpastesMouth rinses

Goods & Services

Cosmetics; Soap; Shampoos; Perfumery; Ethereal oils; Hair care lotions; Hair care preparations, not for medical purposes; Hair nourishers; Hair preparations and treatments; Scalp treatments (Non-medicated -); Dentifrices. Nutritional supplements for medical purposes for hair and nail care.

Abstract

The present invention relates to oral care composition comprising o-cymen-5-ol, dipotassium glycyrrhizinate, 4-hydroxyacetophenone and water, as well as to their use in oral care, in particular for the treatment and/or prevention of dental plaque formation, caries formation, calculus formation, halitosis, gingivitis, periodontitis, peri-implant mucositis and/or periimplantitis.

IPC Classes  ?

• A61K 8/34 - Alcohols
• A61K 8/35 - Ketones, e.g. quinones, benzophenone
• A61K 8/60 - SugarsDerivatives thereof
• A61K 8/63 - SteroidsDerivatives thereof
• A61Q 11/00 - Preparations for care of the teeth, of the oral cavity or of dentures, e.g. dentifrices or toothpastesMouth rinses

Abstract

The present invention relates to oral care composition comprising a zinc salt having a solubility in water higher than 3.0·104 mg/L at 25 ºC, an isopropylmethylphenol compound, a glycyrrhizin derivative and water, as well as to their use in oral care, in particular for the treatment and/or prevention of dental plaque formation, caries formation, calculus formation, halitosis, gingivitis, periodontitis, peri-implant mucositis and/or periimplantitis.

IPC Classes  ?

• A61K 8/27 - ZincCompounds thereof
• A61Q 11/00 - Preparations for care of the teeth, of the oral cavity or of dentures, e.g. dentifrices or toothpastesMouth rinses
• A61K 8/34 - Alcohols
• A61K 8/60 - SugarsDerivatives thereof
• A61K 8/63 - SteroidsDerivatives thereof

Abstract

It relates to a buccal composition which comprises an effective amount of octenidine or a pharmaceutically, veterinary or cosmetically acceptable salt thereof, a zinc ion source, and fluoride ion source, together with one or more appropriate oral excipients or carriers.It also relates to a process for its preparation and to its medical uses in the treatment of halitosis, prophylaxis and/or treatment of periodontal diseases, and prophylaxis of dental caries. It also relates to its cosmetic use as an oral care agent.

IPC Classes  ?

• A61K 8/27 - ZincCompounds thereof
• A61K 8/49 - Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
• A61Q 11/00 - Preparations for care of the teeth, of the oral cavity or of dentures, e.g. dentifrices or toothpastesMouth rinses
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 8/21 - FluoridesDerivatives thereof

Abstract

The invention relates to a device for interdental cleaning, comprising a system for generating a gaseous current, configured to circulate a gaseous current in a channel, a system for generating drops of fluid comprising at least one fluid reservoir provided with outlets to a zone of the channel that is separated from the reservoir by one or more permeable elements provided in a manner corresponding to the outlets. The system for generating drops of fluid comprises one or more devices for generating drops via ultrasound, configured such that, when they are activated at a determined frequency, drops of fluid are generated that cross the permeable element from the reservoir towards the zone of the channel, said drops being carried by the gaseous current, thereby producing a current of drops in a gaseous medium towards an outlet of the channel.

IPC Classes  ?

• A61C 17/02 - Rinsing or air-blowing devices, e.g. using fluid jets

Goods & Services

(1) Bleaching preparations for laundry use; Cleaning, scouring and abrasive preparations namely all-purpose cleaners, and scale removing preparations for household purposes; soaps for household use; household detergents; de-greasing preparations for household purposes; de-greasing preparations for household use; detergents for household use; all-purpose cleaning preparations; ammonia for cleaning purposes; perfumery; essential oils for cosmetic use; cosmetics namely face cream, hand cream, body cream, makeup, lip balm; hair lotions; dentifrices; hair treatment preparations namely shampoo, non-medicinal dandruff shampoo and shampoo for preventing hair loss; hair shampoos; dandruff shampoos, not for medical purposes; hair lotions; hair creams; hair care lotions; (2) Pharmaceutical preparations for treating dandruff and hair loss namely medicated hair lotions, medicated hair creams, medicated shampoo and medicated tonic for the hair; medicinal preparation for preventing hair loss; medicated hair lotions for promotion of hair growth; medicated hair lotions namely preparations for destroying lice in the hair; medicinal preparations for preventing hair loss namely pharmaceuticals for preventing hair loss; medicated lotions for promotion of hair growth; dietary supplements for humans for treating dandruff and preventing hair loss;

Abstract

It is provided an orally disintegrating pharmaceutical dosage form comprising cranberry extract in an amount from 3 to 18% by weight relative to the total weight of the composition, a therapeutically effective amount of vitamin C, a hydrophobic colloidal silicon dioxide, a diluent, and one or more another pharmaceutically acceptable excipients or carriers. It is also provided the oral dissolvable pharmaceutical dosage form for use in the prophylaxis and/or treatment of gingivitis or periodontitis.

IPC Classes  ?

• A61K 9/20 - Pills, lozenges or tablets
• A61K 36/45 - Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
• A61K 31/375 - Ascorbic acid, i.e. vitamin CSalts thereof
• A61P 1/02 - Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis

Abstract

The invention provides (4-mercapto-piperidin-4-yl)-aminoacetic acid derivatives of formula (I), or a pharmaceutically acceptable salt or stereoisomer thereof, for use as a medicament, preferably for use in the treatment and/or prophylaxis of gastrointestinal ulcer, as well as pharmaceutical compositions comprising said thiol derivatives, or a pharmaceutically acceptable salt or stereoisomer thereof, and one or more pharmaceutically acceptable carriers.

IPC Classes  ?

• A61K 31/00 - Medicinal preparations containing organic active ingredients
• A61K 31/445 - Non-condensed piperidines, e.g. piperocaine
• A61K 31/455 - Nicotinic acid, i.e. niacinDerivatives thereof, e.g. esters, amides
• A61P 1/04 - Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Abstract

The present invention relates to a strontium salt (I) wherein n is an integer which can take the values of 0 or 1 m is an integer which can take the values of 0 or 1 R is hydrogen or methyl and stereoisomers or hydrates thereof, to methods for its synthesis, and use in the treatment and/or prophylaxis of a cartilage and/or bone disease and/or conditions resulting in a dysregulation of cartilage and/or bone metabolism in a mammal.

IPC Classes  ?

• C07C 55/02 - Dicarboxylic acids
• C07F 3/00 - Compounds containing elements of Groups 2 or 12 of the Periodic Table
• A61K 31/194 - Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
• A61P 19/10 - Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Abstract

The present invention relates to a compound of formula (I), or pharmaceutically acceptable, stereoisomers, salts or solvates thereof to methods for its synthesis, and use in the treatment of pain and to a method of treatment of pain using the compounds of formula (I).

IPC Classes  ?

• C07C 271/54 - Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
• A61K 31/27 - Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, e.g. meprobamate, carbachol, neostigmine
• A61P 25/04 - Centrally acting analgesics, e.g. opioids

Goods & Services

Bleaching preparations and other substances for laundry use; cleaning, polishing, scouring and abrasive preparations; soaps, perfumery, essential oils, cosmetics, hair lotions; dentifrices. Pharmaceutical, veterinary and sanitary preparations; analgesics, dietetic substances for medical use; food for babies, plasters, materials for dressings, material for stopping teeth and dental wax; disinfectants; preparations for destroying vermin; fungicides, herbicides.

Goods & Services

Cleaning, polishing, degreasing and abrasive preparations; bleaching preparations and other substances for laundry use; soaps, perfumery, essential oils, cosmetics, hair lotions; dentifrices.

Abstract

The present invention relates to compounds of formula (I), or pharmaceutically acceptable, stereoisomers, salts or solvates thereof to methods for their synthesis, and use in the treatment of pain.

IPC Classes  ?

• C07C 233/48 - Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a saturated carbon skeleton containing rings
• C07C 271/22 - Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
• C07C 271/54 - Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
• A61K 31/24 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
• A61P 25/04 - Centrally acting analgesics, e.g. opioids

Abstract

This invention relates to a new method for the stereospecif ic thiocarboxylation and nitration of organic compounds for the preparation of compounds according to formula (I): comprising the following steps: (a) reacting a compound of formula (II) with a sulfonic derivative of formula (III) wherein the R is selected from the groups C1-3-alkyl, C1-3-alkyl substituted with 1 to 3 halogen atoms, phenyl, C1-3-alkyl-phenyl and C1-3-alkyl-phenyl wherein the alkyl is substituted with 1 to 3 halogen atoms and G is a halogen atomo or a group -O-SO2-R wherein R is as hereinabove defined to yield a compound of formula (IV) (b) treating compound (IV) with a thiocarboxylic acid of formula (V) or a salt thereof: wherein Z is as defined above, to yield compound (VI) and (c) treating compound (VI) with tetrabutylammonium nitrate to yield a compound of formula (I).

IPC Classes  ?

• C07D 493/04 - Ortho-condensed systems

Abstract

This invention relates to a new method for the stereospecific thiocarboxylation of organic compounds for the preparation of compounds according to formula (I) wherein a compound of formula (II) is reacted with a compound of formula (IIIa) or (IIIb) then treating the obtained product with a thiocarboxylic acid or a salt thereof, and subsequently carrying out a nitration reaction.

IPC Classes  ?

• C07D 493/04 - Ortho-condensed systems

Abstract

The present invention relates to the use of a compound of formula (I) or a tautomer, a pharmaceutically acceptable salt or a solvate thereof as active ingredient(s) in the manufacture of a pharmaceutical composition to heal wounds.

IPC Classes  ?

• A61K 31/34 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
• A61P 17/02 - Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Abstract

The present invention relates to new 3-substituted 6-nitrooxy-hexahydrofuro [3,2- b]furane derivatives possessing a superior pharmacological activity in thrombosis and in coronary ischemia models.

IPC Classes  ?

• C07D 493/04 - Ortho-condensed systems
• A61K 31/34 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
• A61P 9/08 - Vasodilators for multiple indications

Abstract

The present invention relates to stable S-nitrosothiols derivatives of formula (I) having vasodilating effect and which inhibit the aggregation of the platelets and which therefore are useful for the preparation of medicaments for treatment of NO related diseases. The invention also relates to a process for the synthesis of the compounds of formula (I) and to intermediate compounds thereof.

IPC Classes  ?

• C07D 211/54 - Sulfur atoms
• C07D 401/06 - Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• A61K 31/44 - Non-condensed pyridinesHydrogenated derivatives thereof

Abstract

The present invention relates to the use ofa compound of formula (I) or a tautomer, a pharmaceutically acceptable salt, a prodrug or a solvate thereof: as active ingredient(s) in the manufacture of a pharmaceutical composition for the prevention and/or treatment of ophthalmological diseasesmediated by ocular hypertension.

IPC Classes  ?

• A61K 31/34 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
• A61P 27/00 - Drugs for disorders of the senses
• A61P 27/06 - Antiglaucoma agents or miotics
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

Thepresent invention relates to the use of a compound of formula (I) or a tautomer, a pharmaceutically acceptable salt, a prodrug or a solvate thereof : 5 as active ingredient(s) in the manufacture of a pharmaceutical composition for the prevention and/or treatment of intestinal disorders.

IPC Classes  ?

• A61K 31/34 - Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
• A61P 29/00 - Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agentsNon-steroidal antiinflammatory drugs [NSAID]
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Goods & Services

Bleaching preparations and other substances for laundry use; cleaning, polishing, scouring and abrasive preparations; soaps, perfumery, essential oils, cosmetics, hair lotions, dentifrices.

Goods & Services

Bleaching preparations and other substances for laundry use; cleaning, polishing, scouring and abrasive preparations; soaps, perfumery, essential oils, cosmetics, hair lotions, dentifrices.

Goods & Services

Bleaching preparations and other substances for laundry use; cleaning, polishing, scouring and abrasive preparations; soaps, perfumery, essential oils, cosmetics, hair lotions, dentifrices.

Goods & Services

Bleaching preparations and other substances for laundry use; cleaning, polishing, scouring and abrasive preparations; soaps; perfumery, essential oils, cosmetics, hair lotions; dentifrices.

Goods & Services

Bleaching preparations and other substances for laundry use; cleaning, polishing, scouring and abrasive preparations; soaps, perfumery, essential oils, cosmetics, hair lotions, dentifrices.

Goods & Services

Soaps; perfumery, essential oils, cosmetics, hair lotions; dentifrices; cosmetic creams and pomades for cosmetic purposes. Pharmaceutical, veterinary and sanitary products; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; adhesive plaster; disinfectants; products for destroying vermin; fungicides, herbicides; material for stopping teeth and dental wax; antiseptics for preventing and relieving bucco-pharyngeal infections, elixirs.

Goods & Services

Produits pharmaceutiques, vétérinaires et hygiéniques; substances diététiques à usage médical, aliments pour bébés; emplâtres, matériel pour pansements; matières pour plomber les dents et pour empreintes dentaires; désinfectants; produits pour la destruction des animaux nuisibles; fongicides, herbicides.

Goods & Services

Préparations pour blanchir et autres substances pour lessiver; préparations pour nettoyer, polir, dégraisser et abraser; savons, parfumerie, huiles essentielles, cosmétiques, lotions pour les cheveux; dentifrices. Produits pharmaceutiques, vétérinaires et hygiéniques; substances diététiques à usage médical, aliments pour bébés; emplâtres, matériel pour pansements; matières pour plomber les dents et pour empreintes dentaires; désinfectants; produits pour la destruction des animaux nuisibles; fongicides, herbicides.

Goods & Services

Bleaching preparations and other substances for laundry use; cleaning, polishing, grease removing and abrasive preparations; soaps; perfumery, essential oils, cosmetics, hair lotions; dentifrices. Pharmaceutical, veterinary and sanitary products; dietetic substances for medical use, food for babies; plasters, materials for dressings; material for stopping teeth and dental wax; disinfectants; pesticides; fungicides, herbicides.

Goods & Services

Bleaching preparations and other substances for laundry use; cleaning, polishing, degreasing and abrasive preparations; soaps; perfumery, essential oils, cosmetics, hair lotions; dentifrices. Pharmaceutical, veterinary and sanitary preparations; dietetic substances for medical use, food for babies; plasters, material for dressings; materials for filling teeth and making dental impressions; disinfectants; pesticides; fungicides, herbicides.

Goods & Services

Bleaching preparations and other substances for laundry use; cleaning, polishing, degreasing and abrasive preparations; soap; perfumery, essential oils, cosmetics, hair lotions; dentifrices. Pharmaceutical, veterinary and sanitary preparations; dietetic substances adapted for medical use, food for babies; plasters, materials for dressings; material for dental fillings and dental impressions; disinfectants; pesticides; fungicides, herbicides.

Goods & Services

Produits pour les soins de la bouche à usage médical et pour l'odontostomatologie.

Goods & Services

Préparations pour blanchir et autres substances pour lessiver; préparations pour nettoyer, polir, dégraisser et abraser; savons; parfumerie, huiles essentielles, cosmétiques, lotions pour les cheveux; dentifrices.

Goods & Services

Perfumery, sanitary, toiletry and beauty products and in particular dentifrices.

Goods & Services

Bleaching preparations and other substances for laundry use; cleaning, polishing, degreasing and abrasive preparations; soap; perfumery, essential oils, cosmetics, hair lotions; mouth washes, not for medical purposes; dentifrices. Pharmaceutical, veterinary and sanitary preparations; medicinal products for gum and mouth care; dietetic substances adapted for medical use; food for babies; plasters, materials for dressings; material for dental fillings and dental impressions, disinfectants; pesticides; fungicides, herbicides.

Goods & Services

Produits pharmaceutiques à base d'isomères.

Goods & Services

Produits chimiques pour la médecine et la pharmacie, substances, produits et préparations pharmaceutiques, médicamenteux, vétérinaires et curatifs de toutes sortes; diététiques d'usage médicinal, désinfectants et antiparasitaires pour les humains.