Mesosil Inc.

Canada

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Date
2024 3
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Before 2020 2
IPC Class
A61K 31/155 - Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (HN=C(OH)NH2), isothiourea (HN=C(SH)—NH2) 4
A61K 31/4425 - Pyridinium derivatives, e.g. pralidoxime, pyridostigmine 4
A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone 4
A61K 6/84 - Preparations for artificial teeth, for filling teeth or for capping teeth comprising metals or alloys 4
A61K 9/00 - Medicinal preparations characterised by special physical form 4
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Status
Pending 4
Registered / In Force 3

1.

MESOSIL

      
Application Number 1786640
Status Registered
Filing Date 2024-03-28
Registration Date 2024-03-28
Owner Mesosil Inc. (Canada)
NICE Classes  ? 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

Antimicrobial or bioactive additives for preventing and inhibiting bacterial infections, proliferation and growth at the medical device-biological tissue interface or enhancing integration and performance at the medical device-biological tissue interface.

2.

MESOSIL

      
Serial Number 79394278
Status Pending
Filing Date 2024-03-28
Owner Mesosil Inc. (Canada)
NICE Classes  ? 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

Antimicrobial or bioactive additives for use in medical implants or implant material to prevent and inhibit bacterial infections, proliferation and growth where the implant comes into contact with human tissue, or to enhance integration and performance of medical implants or implant material

3.

MESOSIL

      
Application Number 231798000
Status Pending
Filing Date 2024-03-27
Owner Mesosil Inc. (Canada)
NICE Classes  ? 05 - Pharmaceutical, veterinary and sanitary products

Goods & Services

(1) Antimicrobial or bioactive additives for preventing and inhibiting bacterial infections, proliferation and growth at the medical device-biological tissue interface or enhancing integration and performance at the medical device-biological tissue interface

4.

HIGHLY LOADED METAL OXIDE MATERIALS BY SELF-ASSEMBLY FOR EXTENDED BIOLOGICALLY ACTIVE MOLECULE RELEASE IN MEDICAL AND DENTAL APPLICATIONS

      
Application Number 17464211
Status Pending
Filing Date 2021-09-01
First Publication Date 2022-02-24
Owner MESOSIL INC. (Canada)
Inventor
  • Stewart, Cameron Alexander
  • Hatton, Benjamin David
  • Finer, Yoav

Abstract

A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.

IPC Classes  ?

  • A61K 6/84 - Preparations for artificial teeth, for filling teeth or for capping teeth comprising metals or alloys
  • A61L 27/56 - Porous or cellular materials
  • C07C 279/26 - X and Y being nitrogen atoms, i.e. biguanides
  • C07D 213/74 - Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
  • C07C 279/14 - Derivatives of guanidine, i.e. compounds containing the group the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
  • A61K 31/4425 - Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
  • A61K 31/155 - Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (HN=C(OH)NH2), isothiourea (HN=C(SH)—NH2)
  • C07D 213/20 - Quaternary compounds thereof
  • A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
  • A61L 27/54 - Biologically active materials, e.g. therapeutic substances
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61L 27/42 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having an inorganic matrix
  • A61L 27/30 - Inorganic materials
  • A61L 27/44 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
  • A61K 9/14 - Particulate form, e.g. powders
  • A61P 1/02 - Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
  • A01N 25/08 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
  • A61P 31/04 - Antibacterial agents
  • A61P 31/02 - Local antiseptics
  • A61K 9/51 - Nanocapsules
  • A61L 27/32 - Phosphorus-containing materials, e.g. apatite
  • A61K 31/785 - Polymers containing nitrogen
  • A61L 27/12 - Phosphorus-containing materials, e.g. apatite
  • A61L 27/10 - Ceramics or glasses
  • A61L 27/02 - Inorganic materials
  • A01N 43/40 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
  • A01N 47/44 - GuanidineDerivatives thereof
  • A61K 31/20 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid
  • A61K 6/20 - Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
  • A61K 6/35 - Preparations for stabilising dentures in the mouth
  • A61K 6/40 - Primers
  • A61K 6/54 - FillingSealing
  • A61K 6/71 - Fillers
  • A61K 6/74 - Fillers comprising phosphorus-containing compounds
  • A61K 6/76 - Fillers comprising silicon-containing compounds
  • A61K 6/80 - Preparations for artificial teeth, for filling teeth or for capping teeth
  • A61K 6/86 - Al-cements
  • A61K 6/802 - Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics
  • A61K 6/849 - Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
  • A61K 6/853 - Silicates
  • A61K 6/864 - Phosphate cements
  • A61K 6/871 - QuartzSiO2
  • C08K 3/22 - OxidesHydroxides of metals
  • C08K 3/32 - Phosphorus-containing compounds
  • C08L 33/12 - Homopolymers or copolymers of methyl methacrylate

5.

Highly loaded metal oxide materials by self-assembly for extended biologically active molecule release in medical and dental applications

      
Application Number 17463002
Grant Number 12220467
Status In Force
Filing Date 2021-08-31
First Publication Date 2022-01-06
Grant Date 2025-02-11
Owner MESOSIL INC. (Canada)
Inventor
  • Stewart, Cameron Alexander
  • Hatton, Benjamin David
  • Finer, Yoav

Abstract

A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.

IPC Classes  ?

  • A61K 6/84 - Preparations for artificial teeth, for filling teeth or for capping teeth comprising metals or alloys
  • A01N 25/08 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
  • A01N 43/40 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
  • A01N 47/44 - GuanidineDerivatives thereof
  • A61K 6/20 - Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
  • A61K 6/35 - Preparations for stabilising dentures in the mouth
  • A61K 6/40 - Primers
  • A61K 6/54 - FillingSealing
  • A61K 6/71 - Fillers
  • A61K 6/74 - Fillers comprising phosphorus-containing compounds
  • A61K 6/76 - Fillers comprising silicon-containing compounds
  • A61K 6/80 - Preparations for artificial teeth, for filling teeth or for capping teeth
  • A61K 6/802 - Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics
  • A61K 6/849 - Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
  • A61K 6/853 - Silicates
  • A61K 6/86 - Al-cements
  • A61K 6/864 - Phosphate cements
  • A61K 6/871 - QuartzSiO2
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 9/14 - Particulate form, e.g. powders
  • A61K 9/51 - Nanocapsules
  • A61K 31/155 - Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (HN=C(OH)NH2), isothiourea (HN=C(SH)—NH2)
  • A61K 31/20 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid
  • A61K 31/4425 - Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
  • A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
  • A61K 31/785 - Polymers containing nitrogen
  • A61L 27/02 - Inorganic materials
  • A61L 27/10 - Ceramics or glasses
  • A61L 27/12 - Phosphorus-containing materials, e.g. apatite
  • A61L 27/30 - Inorganic materials
  • A61L 27/32 - Phosphorus-containing materials, e.g. apatite
  • A61L 27/42 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having an inorganic matrix
  • A61L 27/44 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
  • A61L 27/54 - Biologically active materials, e.g. therapeutic substances
  • A61L 27/56 - Porous or cellular materials
  • A61P 1/02 - Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
  • A61P 31/02 - Local antiseptics
  • A61P 31/04 - Antibacterial agents
  • C07C 279/14 - Derivatives of guanidine, i.e. compounds containing the group the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
  • C07C 279/26 - X and Y being nitrogen atoms, i.e. biguanides
  • C07D 213/20 - Quaternary compounds thereof
  • C07D 213/74 - Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
  • C08K 3/22 - OxidesHydroxides of metals
  • C08K 3/32 - Phosphorus-containing compounds
  • C08L 33/10 - Homopolymers or copolymers of methacrylic acid esters
  • C08L 33/12 - Homopolymers or copolymers of methyl methacrylate
  • C08L 75/04 - Polyurethanes

6.

Highly loaded metal oxide materials by self-assembly for extended biologically active molecule release in medical and dental applications

      
Application Number 16301773
Grant Number 11129774
Status In Force
Filing Date 2017-05-16
First Publication Date 2019-05-23
Grant Date 2021-09-28
Owner MESOSIL INC. (Canada)
Inventor
  • Stewart, Cameron Alexander
  • Hatton, Benjamin David
  • Finer, Yoav

Abstract

A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.

IPC Classes  ?

  • A61K 8/14 - Liposomes
  • A61K 6/84 - Preparations for artificial teeth, for filling teeth or for capping teeth comprising metals or alloys
  • A61L 27/56 - Porous or cellular materials
  • C07C 279/26 - X and Y being nitrogen atoms, i.e. biguanides
  • C07D 213/74 - Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
  • C07C 279/14 - Derivatives of guanidine, i.e. compounds containing the group the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
  • A61K 31/4425 - Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
  • A61K 31/155 - Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (HN=C(OH)NH2), isothiourea (HN=C(SH)—NH2)
  • C07D 213/20 - Quaternary compounds thereof
  • A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
  • A61L 27/54 - Biologically active materials, e.g. therapeutic substances
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61L 27/42 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having an inorganic matrix
  • A61L 27/30 - Inorganic materials
  • A61L 27/44 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
  • A61K 9/14 - Particulate form, e.g. powders
  • A61P 1/02 - Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
  • A01N 25/08 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
  • A61P 31/04 - Antibacterial agents
  • A61P 31/02 - Local antiseptics
  • A61K 9/51 - Nanocapsules
  • A61L 27/32 - Phosphorus-containing materials, e.g. apatite
  • A61K 31/785 - Polymers containing nitrogen
  • A61L 27/12 - Phosphorus-containing materials, e.g. apatite
  • A61L 27/10 - Ceramics or glasses
  • A61L 27/02 - Inorganic materials
  • A01N 43/40 - Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
  • A01N 47/44 - GuanidineDerivatives thereof
  • A61K 31/20 - Carboxylic acids, e.g. valproic acid having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid
  • A61K 6/20 - Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
  • A61K 6/35 - Preparations for stabilising dentures in the mouth
  • A61K 6/40 - Primers
  • A61K 6/54 - FillingSealing
  • A61K 6/71 - Fillers
  • A61K 6/74 - Fillers comprising phosphorus-containing compounds
  • A61K 6/76 - Fillers comprising silicon-containing compounds
  • A61K 6/80 - Preparations for artificial teeth, for filling teeth or for capping teeth
  • A61K 6/86 - Al-cements
  • A61K 6/802 - Preparations for artificial teeth, for filling teeth or for capping teeth comprising ceramics
  • A61K 6/849 - Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
  • A61K 6/853 - Silicates
  • A61K 6/864 - Phosphate cements
  • A61K 6/871 - QuartzSiO2
  • C08K 3/22 - OxidesHydroxides of metals
  • C08K 3/32 - Phosphorus-containing compounds
  • C08L 33/12 - Homopolymers or copolymers of methyl methacrylate

7.

HIGHLY LOADED METAL OXIDE MATERIALS BY SELF-ASSEMBLY FOR EXTENDED BIOLOGICALLY ACTIVE MOLECULE RELEASE IN MEDICAL AND DENTAL APPLICATIONS

      
Document Number 03023455
Status Pending
Filing Date 2017-05-16
Open to Public Date 2017-11-23
Owner MESOSIL INC. (Canada)
Inventor
  • Stewart, Cameron Alexander
  • Finer, Yoav
  • Hatton, Benjamin David

Abstract

A biocompatible composite material for controlled release is disclosed, comprising a biocompatible metal oxide structure with a loaded network of pores. The pore network of the biocompatible composite material is filled with a uniformly distributed biologically active micellizing amphiphilic molecule, the size of these pores ranging from about 0.5 to about 100 nanometers. The material is characterized in that when exposed to phosphate-buffered saline (PBS), the controlled release of the active amphiphilic molecule is predominantly diffusion-driven over time.

IPC Classes  ?

  • A61L 27/28 - Materials for coating prostheses
  • A61K 6/30 - Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives
  • A61K 6/84 - Preparations for artificial teeth, for filling teeth or for capping teeth comprising metals or alloys
  • A61K 6/884 - Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
  • A61K 9/00 - Medicinal preparations characterised by special physical form
  • A61K 9/14 - Particulate form, e.g. powders
  • A61K 31/155 - Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (HN=C(OH)NH2), isothiourea (HN=C(SH)—NH2)
  • A61K 31/223 - Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-amino acids
  • A61K 31/4425 - Pyridinium derivatives, e.g. pralidoxime, pyridostigmine
  • A61K 31/444 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
  • A61K 47/02 - Inorganic compounds
  • A61K 47/32 - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
  • A61L 27/40 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material
  • A61L 27/42 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having an inorganic matrix
  • A61L 27/54 - Biologically active materials, e.g. therapeutic substances
  • A61P 1/02 - Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
  • C07C 279/14 - Derivatives of guanidine, i.e. compounds containing the group the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
  • C07C 279/26 - X and Y being nitrogen atoms, i.e. biguanides
  • C07D 213/20 - Quaternary compounds thereof
  • C07D 213/74 - Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals