Abstract

The present invention relates to methods for identifying (i) a compound which reduces/inhibits the cellular export of FGF2 by inhibiting FGF2 phosphorylation by Tec kinase, (ii) a compound which reduces/inhibits the interaction between Tec kinase and FGF2, and (iii) a compound which reduces/inhibits the cellular export of FGF2 by binding specifically to phosphorylated FGF2. Furthermore, the present invention provides the compounds identifiable by said methods and pharmaceutical compositions comprising said compounds, in particular, for treating and/or preventing angiogenesis- and/or neovascularization-related diseases such as cancer.

IPC Classes  ?

• G01N 33/74 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving hormones

Abstract

The present invention concerns a method for a location and/or time-dependent alteration of the friction coefficient and/or adhesion force between two bodies, which includes irradiation of one or both contact surfaces between the bodies with radiation, use of the method according to the invention for location and/or time-dependent alteration of the friction coefficient and/or adhesion force between to bodies, a system that includes two bodies in which the friction coefficient and/or the adhesion force between the bodies can be temporarily or permanently altered, and a device for location and/or time-dependent regulation of the friction coefficient and/or adhesion force which includes the system according to the invention and a control unit.

IPC Classes  ?

• C10M 135/00 - Lubricating compositions characterised by the additive being an organic non-macromolecular compound containing sulfur, selenium or tellurium
• C10M 129/04 - Hydroxy compounds

Abstract

The present invention provides skin equivalents comprising human epidermal stem cells which are specifically labeled. The labeling is carried out with a marker capable of labeling slowly proliferating cells, e.g. iododeoxyuridine or PKH26. Particularly, the invention provides skin equivalents comprising labeled epidermal stem cells. The invention also provides corresponding uses and methods of using such cultures, e.g. in the fields of research and medical treatment of skin diseases.

IPC Classes  ?

• C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms

Abstract

The invention relates to a method for the location and/or time-controlled variation of the coefficient of friction and/or the adhesive force between two bodies, comprising radiating one or both contact surfaces between the bodies with radiation. The invention also relates to the use of the inventive method for the location and/or time-controlled variation of the coefficient of friction and/or the adhesive force between two bodies, and to a system comprising two bodies, the coefficient of friction and/or the adhesive force between the two bodies being temporarily or permanently varied. The invention finally relates to a device for the location and/or time-controlled variation of the coefficient of friction and/or the adhesive force, which device comprises the inventive system and a control unit.

IPC Classes  ?

• F16N 15/00 - Lubrication with substances other than oil or greaseLubrication characterised by the use of particular lubricants in particular apparatus or conditions