Abstract

The problem addressed is to provide a method for stably producing β-1,3-1,6-glucan at a high yield from Aureobasidium pullulans AFO-202 and to provide β-1,3-1,6-glucan produced by said method. It was discovered that β-1,3-1,6-glucan is obtained stably at a high yield by using water containing a large amount of SiO2-Si in a step in which Aureobasidium pullulans AFO-202 (FERM MP-19327) is cultured, and the above problem was solved.

IPC Classes  ?

• C12P 19/04 - Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds

Abstract

Compositions for improving gut microbiota, improving behavioural pattern and alpha-synuclein levels, and improving sleep pattern and serum melatonin, especially in children with autism, are provided. Methods are also included for control of gut enterobacteria in children with autism, reconstitution of gut microbiota, and control of enterobacteria in autism and neurodegenerative diseases.

IPC Classes  ?

• A61K 31/716 - Glucans
• A61K 36/062 - Ascomycota
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

Methods for producing a novel β-1,3-1,6-glucan exhibiting an excellent anticancer action are provided. The methods can include using a novel black yeast-like bacteria is used in producing the β-1,3-1,6-glucan and culturing an Aureobasidium pullulans APNN-M 163 strain (accession number: NITE BP-03377) in a culture medium.

IPC Classes  ?

• C12P 19/04 - Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
• C08B 37/00 - Preparation of polysaccharides not provided for in groups Derivatives thereof
• C12R 1/01 - Bacteria or actinomycetales

Abstract

Compositions and methods for preventing and/or treating fibrosis with a beta-blucan are provided.

IPC Classes  ?

• A61K 31/716 - Glucans
• A61K 36/062 - Ascomycota
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A61P 11/00 - Drugs for disorders of the respiratory system
• A61P 13/12 - Drugs for disorders of the urinary system of the kidneys

Abstract

A beta-glucan, a composition comprising the beta-glucan, and a method of using the beta-glucan for improving, preventing and/or treating muscular dystrophy are provided.

IPC Classes  ?

• A61K 31/716 - Glucans
• A61K 36/062 - Ascomycota
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system

Abstract

Methods for inducing, enhancing and/or balancing an immune response are provided. The methods include administering a beta-glucan produced by Aureobasidium pullulans AFO-202 (FERM BP-19327). The methods include administering a beta-glucan produced by Aureobasidium pullulans AFO-202 (FERM BP-19327) as a vaccine adjuvant.

IPC Classes  ?

• A61K 31/716 - Glucans
• A61P 35/00 - Antineoplastic agents
• A61P 31/14 - Antivirals for RNA viruses
• A61K 9/00 - Medicinal preparations characterised by special physical form

Abstract

The present invention is to provide a beta-glucan, a composition comprising the beta-glucan, and a method of use of the beta-glucan, for improving, preventing and/or treating muscular dystrophy.

IPC Classes  ?

• A23L 33/145 - Extracts
• A23L 33/125 - Modifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing carbohydrate syrupsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugarsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing sugar alcoholsModifying nutritive qualities of foodsDietetic productsPreparation or treatment thereof using additives containing starch hydrolysates
• A61K 31/716 - Glucans
• A61P 21/00 - Drugs for disorders of the muscular or neuromuscular system
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The present invention is to provide a beta-glucan, a composition comprising the beta-glucan, and a method of use of the beta-glucan, for preventing and/or treating fibrosis.

IPC Classes  ?

• A61K 31/716 - Glucans
• A61P 1/00 - Drugs for disorders of the alimentary tract or the digestive system
• A61P 1/16 - Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
• A61P 3/00 - Drugs for disorders of the metabolism
• A61P 35/00 - Antineoplastic agents

Abstract

The purpose of the present invention is to provide: a method for producing novel β-1,3-1,6-glucan exhibiting an excellent anticancer action; novel black yeast-like bacteria used in said production method; and novel β-1,3-1,6-glucan exhibiting an excellent anticancer action. A method for producing β-1,3-1,6-glucan according to the present invention is characterized by comprising a step for culturing an Aureobasidium pullulans APNN-M163 strain (accession number: NITE BP-03377) in a culture medium.

IPC Classes  ?

• C12P 19/04 - Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
• C12N 1/14 - Fungi Culture media therefor

Abstract

The present invention relates to a composition for improving gut microbiota, especially for prophylactic, ameliorating and/or curative treatment of autism spectrum disorders (ASD), multiple sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD) and/or epilepsy. The present invention also relates to a composition for improving behavioural pattern and alpha-synuclein levels, especially in autism spectrum disorder.　 The present invention further relates to a composition for improving sleep pattern and serum melatonin, especially in children with autism spectrum disorder.

IPC Classes  ?

• A61K 36/06 - Fungi, e.g. yeasts
• A61K 31/716 - Glucans
• A61P 25/00 - Drugs for disorders of the nervous system
• A61P 25/08 - AntiepilepticsAnticonvulsants
• A61P 25/16 - Anti-Parkinson drugs
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

The present invention is to provide a composition for inducing, enhancing and/or balancing an immune response, comprising a beta-glucan produced by Aureobasidium pullulans AFO-202 (FERM BP-19327).　The present invention is also to provide a vaccine adjuvant comprising a beta-glucan produced by Aureobasidium pullulans AFO-202 (FERM BP-19327).　The present invention is further to provide a method for inducing, enhancing and/or balancing an immune response with a beta-glucan produced by Aureobasidium pullulans AFO-202 (FERM BP-19327).

IPC Classes  ?

• A61K 31/716 - Glucans
• A61P 7/02 - Antithrombotic agentsAnticoagulantsPlatelet aggregation inhibitors
• A61P 31/14 - Antivirals for RNA viruses
• A61P 35/00 - Antineoplastic agents