Metal polymer complexes and metal polymer complexes adapted for capturing carbon dioxide are disclosed herein. In accordance with one aspect, provided is a metal polymer complex comprising a polymer comprising at least one monomer having an amine group, the polymer complexed with a transition metal selected from nickel, zinc, copper, and a combination of two or more thereof. According to another aspect, provided is a method for capturing carbon dioxide comprising: providing an inlet gas comprising carbon dioxide and water; producing a carbonate, a bicarbonate, a salt thereof, or a combination thereof to remove carbon dioxide from the inlet gas by contacting the inlet gas with a polymer complex substrate; and removing the carbonate, the bicarbonate, the salt thereof, or the combination thereof from the polymer complex substrate by contacting the polymer complex substrate with a regenerant solution comprising water and at least one of a salt or an acid.
B01J 20/22 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising organic material
Technologies for atomic force microscopy (AFM)-based photothermal two-dimensional infrared (2DIR) spectroscopy are disclosed. Techniques may comprise providing pulsed light from an infrared (IR) laser source. A pulse sequence may be generated from the IR light. The pulse sequence may comprise one or more time delays among constituent pulses. The pulsed IR light may be focused on matter in a sample region. The pulsed IR light may interact with the matter in the sample region. One or more photothermal expansion mechanical actions in the matter of the sample region may be measured. One or more signals corresponding to the one or more measured photothermal expansion actions may be created and may be recorded as a function of the one or more time delays. A photothermal two-dimensional (2D) spectrum may be extracted from the one or more signals as recorded as a function of the one or more time delays.
G01Q 30/02 - Non-SPM analysing devices, e.g. SEM [Scanning Electron Microscope], spectrometer or optical microscope
G01N 21/35 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
Described herein are agricultural compositions comprising an adduct of urea comprising: urea; and an inorganic salt; wherein the adduct has an average particle size ranging from about 0.1 microns to about 10 microns.
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (USA)
THE CHILDREN'S HOSPITAL OF PHILADELPHIA (USA)
LEHIGH UNIVERSITY (USA)
Inventor
Yang, Shu
Chen, Mingtao
Tucker, Alexander
Jagota, Anand
Wu, Yue
Abstract
A reversibly adhesive film, comprising: at least two hydroxyl-bearing polymer chains being crosslinked by one or more boronic ester bonds, the film having accessible hydroxyl groups at a surface of the film. An reversible adhesive, comprising: a first film layer, the first film layer comprising at least two first hydroxyl-bearing polymer chains crosslinked by first crosslinks that comprise one or more boronic ester bonds; and a second film layer, the first second layer comprising at least two second hydroxyl-bearing polymer chains crosslinked by second crosslinks that comprise one or more boronic ester bonds, wherein (1) the first hydroxyl-bearing polymer chains differ from the second hydroxyl-bearing polymer chains in one or more of composition and concentration, or (2) the boronic ester bonds are present in the first film layer at a different density than the boronic ester bonds in the second film layer, or (3) both (1) and (2).
Medium to high entropy alloys and methods for producing the same are disclosed herein. In accordance with a first aspect, provided is a method for producing a medium to high entropy alloy. The method may comprise mixing a feed composition to obtain a metal oxide mixture, wherein the feed composition comprises four or more metal oxides selected from alkali metal oxides, alkaline carth metal oxides, lanthanoid oxides, actinoid oxides, transition metal oxides, post-transition metal oxides, or a combination of two or more thereof: and reducing the metal oxide mixture to produce a medium to high entropy alloy.
A system and method of performing sparse accumulation in column-wise sparse general matrix-matrix multiplication (SpGEMM) algorithms. The method includes receiving a request to perform SpGEMM based on a first matrix and a second matrix. The method includes accumulating, in a hardware buffer, a hash key and an intermediate multiplication result of the first matrix and the second matrix. The method includes performing a probe search of a hardware cache to identify a match between the hash key and a partial sum associated with the first matrix and the second matrix. The method includes generating, by a hardware adder, a multiplication result based on the partial sum and the intermediate multiplication result from the accumulation waiting buffer.
41 - Education, entertainment, sporting and cultural services
Goods & Services
Education services, namely, an in-person and online program which educates parents and caregivers on the subject of caring for children affected by the symptoms of attention-deficit/hyperactivity disorder
42442433, HF:Acetic Acid, wherein the etching temperature ranges from about 20 °C to about 30 °C, and wherein the period of etching time ranges from about 10 min to about 60 min, and wherein the initial glass body has a first major surface opposite a second major surface and a side surface extending between the first major surface and the second major surface, wherein the etchant blend contacts at least the first major surface of the initial glass body.
A method for synthesizing a nitrogen-containing material includes mixing a nitrogen-containing lithiated precursor with at least one element other than lithium and nitrogen to yield a mixed composition, placing the mixed composition in an apparatus, supplying nitrogen gas into the apparatus, and heating the apparatus to an elevated temperature at an elevated pressure for a predetermined period of time to yield the nitrogen-containing material.
Carbon capture systems, apparatuses, and methods thereof are disclosed herein. According to an aspect, provided is a capacitive carbon capture system comprising: carbon capture module(s) comprising: a first current collector; a second current collector and spaced from the first current collector; a first carbon capture cell and a second carbon capture cell, the first carbon capture cell and the second carbon capture cell each comprising: a first electrode comprising a first surface and a second surface opposed the first surface, a second electrode spaced from the first electrode, the second electrode comprising a first surface and a second surface opposed the first surface, an electrolyte solution in contact with the second surface of the first electrode and the first surface of the second electrode, and a gas permeable layer comprising a first surface and a second surface opposed to the first surface; and a barrier extending between.
B01D 53/32 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by electrical effects other than those provided for in group
B01D 53/04 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
H01G 11/00 - Hybrid capacitors, i.e. capacitors having different positive and negative electrodesElectric double-layer [EDL] capacitorsProcesses for the manufacture thereof or of parts thereof
H01G 11/06 - Hybrid capacitors with one of the electrodes allowing ions to be reversibly doped thereinto, e.g. lithium ion capacitors [LIC]
12.
HIGH PRESSURE SPATIAL CHEMICAL VAPOR DEPOSITION SYSTEM AND RELATED PROCESS
High pressure spatial chemical vapor deposition apparatuses and related process are disclosed for forming thin films on a substrate. An enclosure includes plural process chambers fluidly isolated from each other by radial separating barriers. Each chamber contains a different source gas comprising volatile reactive species. The substrate is supported beneath the chambers on a rotating heated susceptor. Rotation of the susceptor carries the substrate in a path which consecutively exposes the substrate to the volatile reactive species in each process chamber. The gases first mix in the gaseous boundary layer formed adjacent the substrate. A thin film gradually grows in thickness on the substrate with each successive pass and exposure to the reactive species in each process chamber. The tool pressure and boundary layer thickness may be dynamically varied during the film formation process run via a programmable controller to alter the film composition and features formed on the substrate.
C23C 16/455 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for introducing gases into the reaction chamber or for modifying gas flows in the reaction chamber
C23C 16/30 - Deposition of compounds, mixtures or solid solutions, e.g. borides, carbides, nitrides
C23C 16/458 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for supporting substrates in the reaction chamber
C30B 25/10 - Heating of the reaction chamber or the substrate
H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
H01L 21/687 - Apparatus specially adapted for handling semiconductor or electric solid state devices during manufacture or treatment thereofApparatus specially adapted for handling wafers during manufacture or treatment of semiconductor or electric solid state devices or components for supporting or gripping using mechanical means, e.g. chucks, clamps or pinches
13.
NANO-MECHANICAL INFRARED SPECTROSCOPY SYSTEM AND METHOD USING GATED PEAK FORCE IR
An apparatus and method of performing sample characterization with an AFM and a pulsed IR laser directed at the tip of a probe of the AFM. Gated laser pulsing and gated detection based on a lock-in amplifier, boxcar integrator or FFT may be employed in Peak force tapping operation. Nano-spectroscopic measurements with sub-20 nm, and even sub- 10 nm resolution can be executed together with nano-mechanical and other property measurements.
An apparatus and method of performing sample characterization with an AFM and a pulsed IR laser directed at the tip of a probe of the AFM. Gated laser pulsing and gated detection based on a lock-in amplifier, boxcar integrator or FFT may be employed in Peak force tapping operation. Nano-spectroscopic measurements with sub-20 nm, and even sub-10 nm resolution can be executed together with nano-mechanical and other property measurements.
An acoustic transmission device may communicate sensing data via one or more multiple-input multiple-output (MIMO) transmissions. The device may comprise a serial peripheral interface (SPI) and/or a phase shifting key (PSK) modulator. The device may be configured to provide a first SPI signal, perhaps including one or more coded information bits, to the PSK modulator. The device may provide a second SPI signal, perhaps including a synchronous clock signal, to the PSK modulator. The device may generate of one or more symbols on N transmit branches based on the first SPI signal. The device may generate of at least one carrier frequency with one or more phases to form one or more phased carriers based on the second SPI signal. The device may control a transmission of the sensing data (e.g., video) via the one or more symbols on the N transmit branches on the one or more phased carriers.
Described herein is a 3D-printed scaffold comprising a peptide-polymer conjugate, the peptide-polymer conjugate having the structure: X—Y—Z—Y—X, wherein X is a biologically active peptide, Y is a linker moiety, and Z is a biocompatible and biodegradable polymer.
36 - Financial, insurance and real estate services
41 - Education, entertainment, sporting and cultural services
Goods & Services
providing financial aid for college students and doctoral candidates educational services, namely, offering courses of instruction at the college and doctoral candidate level
18.
CONCRETE COMPOSITIONS AND APPARATUSES EMPLOYING THE SAME
Concrete materials and thermal energy storage devices employing such concrete materials are disclosed herein. The concrete material may include fibers in an amount ranging from about 1 to about 2 vol. %; an aggregate in an amount ranging from about 50 to about 80 vol. %, wherein the aggregates comprises siliceous aggregate and optionally carbonate aggregate; and a cementitious material in an amount from about 12 to about 20 vol. %, wherein the cementitious material comprises a combination of about 70 to about 85 vol. % of Portland cement and about 15 to about vol. % of silica fume, wherein all volume percentages unless otherwise indicated are based on the total volume of the concrete material.
C04B 20/00 - Use of materials as fillers for mortars, concrete or artificial stone according to more than one of groups and characterised by shape or grain distributionTreatment of materials according to more than one of the groups specially adapted to enhance their filling properties in mortars, concrete or artificial stoneExpanding or defibrillating materials
The disclosure relates to a system comprising a device that includes electrodes and a sensor operably connected in electrical communication with a controller housing a computer program product that calculates heart rate and mean arterial blood pressure in the circulatory system of a subject by the sensor being placed at or proximate to the cardiac tissue of the subject. Electrodes on the device stimulate the vagal nerve to restore heart rate and arterial blood pressure to normal levels if an abnormality is detected.
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
A61B 5/02 - Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
An acoustic transmission device may communicate sensing data via one or more multiple-input multiple-output (MIMO) transmissions. The device may comprise a serial peripheral interface (SPI) and/or a phase shifting key (PSK) modulator. The device may be configured to provide a first SPI signal, perhaps including one or more coded information bits, to the PSK modulator. The device may provide a second SPI signal, perhaps including a synchronous clock signal, to the PSK modulator. The device may generate of one or more symbols on N transmit branches based on the first SPI signal. The device may generate of at least one carrier frequency with one or more phases to form one or more phased carriers based on the second SPI signal. The device may control a transmission of the sensing data (e.g., video) via the one or more symbols on the N transmit branches on the one or more phased carriers.
A thermal energy storage device may include a heat storage medium, one or more thermosyphons, a discharging plenum chamber, and a discharging plenum chamber. The one or more thermosyphons may include an evaporative section configured to charge the thermal energy storage device, a condensing section configured to discharge the thermal energy storage device, and a heat transfer section extending between the evaporative section and the condensing section and fluidically coupled to the evaporative section and the condensing section. At least a portion of the heat transfer section may be disposed in the solid heat storage medium. At least a portion of the evaporative section and the condensing section may be disposed outside the solid heat storage medium.
Metal polymer complexes and metal polymer complexes adapted for capturing carbon dioxide are disclosed herein. In accordance with one aspect, provided is a metal polymer complex comprising a polymer comprising at least one monomer having an amine group, the polymer complexed with a transition metal selected from nickel, zinc, copper, and a combination of two or more thereof. According to another aspect, provided is a method for capturing carbon dioxide comprising: providing an inlet gas comprising carbon dioxide and water; producing a carbonate, a bicarbonate, a salt thereof, or a combination thereof to remove carbon dioxide from the inlet gas by contacting the inlet gas with a polymer complex substrate; and removing the carbonate, the bicarbonate, the salt thereof, or the combination thereof from the polymer complex substrate by contacting the polymer complex substrate with a regenerant solution comprising water and at least one of a salt or an acid.
B01J 20/02 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material
B01D 53/14 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by absorption
Metal polymer complexes and metal polymer complexes adapted for capturing carbon dioxide are disclosed herein. In accordance with one aspect, provided is a metal polymer complex comprising a polymer comprising at least one monomer having an amine group, the polymer complexed with a transition metal selected from nickel, zinc, copper, and a combination of two or more thereof. According to another aspect, provided is a method for capturing carbon dioxide comprising: providing an inlet gas comprising carbon dioxide and water; producing a carbonate, a bicarbonate, a salt thereof, or a combination thereof to remove carbon dioxide from the inlet gas by contacting the inlet gas with a polymer complex substrate; and removing the carbonate, the bicarbonate, the salt thereof, or the combination thereof from the polymer complex substrate by contacting the polymer complex substrate with a regenerant solution comprising water and at least one of a salt or an acid.
B01D 53/14 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by absorption
B01J 20/02 - Solid sorbent compositions or filter aid compositionsSorbents for chromatographyProcesses for preparing, regenerating or reactivating thereof comprising inorganic material
National Technology & Engineering Solutions of Sandia, LLC (USA)
Lehigh University (USA)
Inventor
Babuska, Tomas Farley
Kustas, Andrew
Grejtak, Tomas
Abstract
Polytetrafluoroethylene filled with FeCo microparticles provides an ultralow wear, magnetic, multifunctional tribological material. For example, PTFE filled with an 5 wt. % of equiatomic, prealloyed FeCo powder resulted in steady state wear rates of 2.7×10−7 mm3/Nm, approaching that of PTFE-filled alumina. Comparable wear rates were not recovered for PTFE filled with just iron or cobalt microparticles.
A polymer injection molding system in one embodiment includes a manifold comprising internal flow conduits configured for conveying polymer in a fluidic state. The manifold may be part of a hot or cold runner type molding unit. An injection nozzle fluidly coupled to the flow conduits interfaces with a mold cavity and is configured to inject polymer therein to form a molded article. The nozzle has a tubular valve body defining a central axial passage which receives a movable elongated valve pin. The valve pin is linearly movable to stop or permit polymer injection from the nozzle. The valve pin is further rotatable via a rotary drive mechanism to induce shear on the polymer. This maintains the polymer in its flowable fluidic state between molding cycles to prevent polymer cold slug formation within the nozzle which can disrupt flow resulting in incompletely formed articles.
A system for ultraviolet irradiation of objects and a method of using this system is disclosed. The system includes: an illuminating device positioned in a center section of an octagon shaped a base area and including one or more elongated light sources, each emitting ultraviolet light given by shortwave ultraviolet light (UV-C light) and extending in parallel to a normal on the base area; a set of rotatable mesh grids arranged around the base area such that the mesh grids surround the illuminating device and configured to be equipped with the objects; and a set of reflectors including a set of movable side reflectors, wherein the reflectors are configured to be arranged such, that they form a resonator surrounding the mesh grids surrounding the illuminating device.
B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (USA)
CHILDREN'S HOSPITAL OF PHILADELPHIA (USA)
LEHIGH UNIVERSITY (USA)
Inventor
Yang, Shu
Chen, Mingtao
Tucker, Alexander
Jagota, Anand
Wu, Yue
Abstract
A reversibly adhesive film, comprising: at least two hydroxyl-bearing polymer chains being crosslinked by one or more boronic ester bonds, the film having accessible hydroxyl groups at a surface of the film. An reversible adhesive, comprising: a first film layer, the first film layer comprising at least two first hydroxyl-bearing polymer chains crosslinked by first crosslinks that comprise one or more boronic ester bonds; and a second film layer, the first second layer comprising at least two second hydroxyl-bearing polymer chains crosslinked by second crosslinks that comprise one or more boronic ester bonds, wherein (1) the first hydroxyl-bearing polymer chains differ from the second hydroxyl-bearing polymer chains in one or more of composition and concentration, or (2) the boronic ester bonds are present in the first film layer at a different density than the boronic ester bonds in the second film layer, or (3) both (1) and (2).
Medium to high entropy alloys and methods for producing the same are disclosed herein. In accordance with a first aspect, provided is a method for producing a medium to high entropy alloy. The method may comprise mixing a feed composition to obtain a metal oxide mixture, wherein the feed composition comprises four or more metal oxides selected from alkali metal oxides, alkaline earth metal oxides, lanthanoid oxides, actinoid oxides, transition metal oxides, post-transition metal oxides, or a combination of two or more thereof; and reducing the metal oxide mixture to produce a medium to high entropy alloy.
There may be two active snubbers for direct current (dc) solid-state circuit breakers (SSCBs): metal-oxide-varistor with resistor-capacitor-switch (MOV-RCS) and active-MOV with resistor-capacitor-diode (AMOV-RCD). In the snubber branch, either half- or full-controlled switch can be used, leading to four topologies. The improved snubbers offer several improvements: 1) MOV is disconnected from the power line during SSCB OFF-state, which enhances reliability as neither voltage nor power appears on MOV; 2) voltage utilization rate ηv of the main switch is remarkably increased, which improves efficiency and power density, and reduces design cost shows experiments of five prototypes are conducted including four proposed snubbers and a comparison with conventional MOV-RCD snubber.
H02H 3/087 - Emergency protective circuit arrangements for automatic disconnection directly responsive to an undesired change from normal electric working condition, with or without subsequent reconnection responsive to excess current for DC applications
H01H 9/16 - Indicators for switching condition, e.g. "on" or "off"
H01H 9/54 - Circuit arrangements not adapted to a particular application of the switching device and for which no provision exists elsewhere
H03K 17/687 - Electronic switching or gating, i.e. not by contact-making and -breaking characterised by the use of specified components by the use, as active elements, of semiconductor devices the devices being field-effect transistors
Methods, systems, and apparatuses for recovering water from an aqueous stream containing a solute are disclosed herein. In accordance with an aspect, provided is method comprising receiving an inlet brine stream comprising water and a solute; producing a concentrated brine stream by contacting the inlet brine stream with an ion exchange resin configured to extract water from the inlet brine stream, the ion exchange resin comprising a plurality of pores adapted to receive water molecules; ceasing the contact of the ion exchange resin with the inlet brine stream and the concentrated brine stream; and evaporating at least a portion of the water contained in the ion exchange resin aided by unsaturated air with less than 100% relative humidity using an evaporation unit.
C02F 1/42 - Treatment of water, waste water, or sewage by ion-exchange
C02F 1/04 - Treatment of water, waste water, or sewage by heating by distillation or evaporation
B01D 1/14 - Evaporating with heated gases or vapours in contact with the liquid
B01D 5/00 - Condensation of vapoursRecovering volatile solvents by condensation
B01J 47/014 - Ion-exchange processes in generalApparatus therefor in which the adsorbent properties of the ion-exchanger are involved, e.g. recovery of proteins or other high-molecular compounds
B01J 47/06 - Column or bed processes during which the ion-exchange material is subjected to a physical treatment, e.g. heat, electric current, irradiation or vibration
B01J 43/00 - Amphoteric ion-exchange, i.e. using ion-exchangers having cationic and anionic groupsUse of material as amphoteric ion-exchangersTreatment of material for improving their amphoteric ion-exchange properties
32.
LABEL-FREE CLASSIFICATION OF CELLS BY IMAGE ANALYSIS AND MACHINE LEARNING
Technologies are disclosed for distinguishing among different types of cells. Techniques may include receiving a plurality of first images. The plurality of first images may depict first cells of a first type or a second type. Techniques may include, for each of the plurality of first images, receiving an indicator identifying whether the first image depicts a first cell of the first type or the second type. Techniques may include inputting, into a deep-learning (DL) model, the plurality of first images and the indicator for each of the plurality of first images. Techniques may include inputting, into the DL model, a second image comprising a second cell of the first type or the second type. Techniques may include determining whether the second cell is of the first type or the second type based on the plurality of first images and the indicator for each of the plurality of first images.
Systems, apparatuses, and methods for realizing a peak-force scattering scanning near-field optical microscopy (PF-SNOM). Conventional scattering-type microscopy (s-SNOM) techniques uses tapping mode operation and lock-in detections that do not provide direct tomographic information with explicit tip-sample distance. Using a peak force scattering-type scanning near-field optical microscopy with a combination of peak force tapping mode and time-gated light detection, PF-SNOM enables direct sectioning of vertical near-field signals from a sample surface for both three-dimensional near-field imaging and spectroscopic analysis. PF-SNOM also delivers a spatial resolution of 5 nm and can simultaneously measure mechanical and electrical properties together with optical near-field signals.
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (USA)
LEHIGH UNIVERSITY (USA)
Inventor
Yang, Shu
Chen, Mingtao
Jagota, Anand
Abstract
Provided are thermally-responsive reversible adhesive materials. The materials can comprise a polymer composition, comprising: a polymeric hydrogel; and a thermoresponsive polymer, the polymeric hydrogel and the thermoresponsive polymer being arranged as an interpenetrating network, the thermoresponsive polymer being soluble in water, the thermoresponsive polymer having a lower critical solution temperature (LCST), and the thermoresponsive polymer chains being dispersed within the polymeric hydrogel such that when the thermoresponsive polymer attains a temperature above the LCST, the thermoresponsive polymer becomes insoluble and forms physical crosslinks between chains of the polymeric hydrogel.
A plasmonic laser array device may comprise a first microcavity element having a first radiating end facet and a second radiating end facet opposite the first radiating end facet in a longitudinal direction of the device. The device may comprise a second microcavity element having a third radiating end facet and a fourth radiating end facet opposite the third radiating facet in the longitudinal direction. The device may comprise a first microcavity gap configured to separate the first microcavity element and the second microcavity element in the longitudinal direction. The device may comprise a bottom (e.g., metal) layer configured to underly the first microcavity element, the second microcavity element, and the first microcavity gap. The device may comprise an arrangement that places the first microcavity element and the second microcavity element into a phase-locked orientation for a phased-locked operation of the plasmonic laser array device.
H01S 5/10 - Construction or shape of the optical resonator
H01S 5/062 - Arrangements for controlling the laser output parameters, e.g. by operating on the active medium by varying the potential of the electrodes
H01S 5/34 - Structure or shape of the active regionMaterials used for the active region comprising quantum well or superlattice structures, e.g. single quantum well [SQW] lasers, multiple quantum well [MQW] lasers or graded index separate confinement heterostructure [GRINSCH] lasers
36.
CONTROLLING FRICTION CHARACTERISTICS OF RESILIENT MEMBERS USING NEAR-SURFACE MICROSTRUCTURES
Resilient members having near-surface architectures including microstructures for controlling friction are provided. A film-terminated array of fibrils having a sharp film/fibril juncture exhibits an unexpectedly large enhancement of adhesion, static friction and sliding friction. The enhancement is provided against rough indenters. A film-terminated array of elongated ridges and valleys unexpectedly exhibits low adhesion, and an unexpectedly large enhancement of sliding friction. The film-terminated ridge/valley design provides an anisotropic structure with direction-dependent frictional properties. The increase in sliding friction force varies as a function of interfibrillar spacing, and corresponds to a mode in which buckling of the terminal film occurs. The near surface architectures may be designed with varying scales and varying parameters to provide performance characteristics tailored to various applications. By way of example, the film-terminated ridge/valley array may be incorporated in motor vehicles tires to provide low rolling resistance and high sliding friction allow for high-performance braking during vehicle operation.
B32B 3/08 - Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by features of form at particular places, e.g. in edge regions characterised by added members at particular parts
B32B 27/08 - Layered products essentially comprising synthetic resin as the main or only constituent of a layer next to another layer of a specific substance of synthetic resin of a different kind
B32B 3/30 - Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a particular shape of the outline of the cross-section of a continuous layerLayered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a layer with cavities or internal voids characterised by a layer formed with recesses or projections, e.g. grooved, ribbed
A polymer injection molding system in one embodiment includes a manifold comprising internal flow conduits configured for conveying polymer in a fluidic state. The manifold may be part of a hot or cold runner type molding unit. An injection nozzle fluidly coupled to the flow conduits interfaces with a mold cavity and is configured to inject polymer therein to form a molded article. The nozzle has a tubular valve body defining a central axial passage which receives a movable elongated valve pin. The valve pin is linearly movable to stop or permit polymer injection from the nozzle. The valve pin is further rotatable via a rotary drive mechanism to induce shear on the polymer. This maintains the polymer in its flowable fluidic state between molding cycles to prevent polymer cold slug formation within the nozzle which can disrupt flow resulting in incompletely formed articles.
A polymer injection molding system in one embodiment includes a manifold comprising internal flow conduits configured for conveying polymer in a fluidic state. The manifold may be part of a hot or cold runner type molding unit. An injection nozzle fluidly coupled to the flow conduits interfaces with a mold cavity and is configured to inject polymer therein to form a molded article. The nozzle has a tubular valve body defining a central axial passage which receives a movable elongated valve pin. The valve pin is linearly movable to stop or permit polymer injection from the nozzle. The valve pin is further rotatable via a rotary drive mechanism to induce shear on the polymer. This maintains the polymer in its flowable fluidic state between molding cycles to prevent polymer cold slug formation within the nozzle which can disrupt flow resulting in incompletely formed articles.
A polymer injection molding system in one embodiment includes a manifold comprising internal flow conduits configured for conveying polymer in a fluidic state. The manifold may be part of a hot or cold runner type molding unit. An injection nozzle fluidly coupled to the flow conduits interfaces with a mold cavity and is configured to inject polymer therein to form a molded article. The nozzle has a tubular valve body defining a central axial passage which receives a movable elongated valve pin. The valve pin is linearly movable to change the nozzle between open and closed positions for discharging or stopping polymer flow therefrom. The valve pin is further rotatable about its axis to induce shear on the polymer. This maintains the polymer in its flowable fluidic state between molding cycles to prevent polymer cold slug formation within the nozzle which can disrupt the flow resulting in incompletely formed articles.
High pressure spatial chemical vapor deposition apparatuses and related process are disclosed for forming thin films on a substrate. An enclosure includes plural process chambers fluidly isolated from each other by radial separating barriers. Each chamber contains a different source gas comprising one or more volatile reactive species. The substrate is supported beneath the chambers on a rotating heated susceptor. Rotation of the susceptor carries the substrate in a path which consecutively exposes the substrate to the volatile reactive species in each process chamber. The gases first mix in the gaseous boundary layer formed adjacent the substrate. A thin film gradually grows in thickness on the substrate with each successive pass and exposure to the volatile reactive species in each of the individual process chambers. The film may be grown at high pressures exceeding 1 atmosphere in some implementations. A modular design includes an outer shell and different interchangeable process inserts.
C23C 16/455 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for introducing gases into the reaction chamber or for modifying gas flows in the reaction chamber
C23C 16/30 - Deposition of compounds, mixtures or solid solutions, e.g. borides, carbides, nitrides
C23C 16/458 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for supporting substrates in the reaction chamber
C30B 25/10 - Heating of the reaction chamber or the substrate
H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
H01L 21/687 - Apparatus specially adapted for handling semiconductor or electric solid state devices during manufacture or treatment thereofApparatus specially adapted for handling wafers during manufacture or treatment of semiconductor or electric solid state devices or components for supporting or gripping using mechanical means, e.g. chucks, clamps or pinches
41.
Open-shell pi-conjugated molecules exhibiting multidimensional intermolecular covalency, compositions and process for preparing
Disclosed herein are compound capable of exploiting non-bonding electron densities, for example, cationic open-shell, pi-conjugated bisphenalenyls wherein intermolecular covalent bonding interactions can occur in multiple dimensions. Further disclosed are compositions comprising the disclosed compounds and process for the preparation thereof.
A system (100) for ultraviolet irradiation of objects (9) and a method of using this system (100) is disclosed. The system (100) comprises: an illuminating device (1) positioned in a center section (3) of an octagon shaped a base area (5) and including one or more elongated light sources (13), each emitting ultraviolet light given by shortwave ultraviolet light (UV-C light) and extending in parallel to a normal on the base area (5); a set of rotatable mesh grids (7) arranged around the base area (5) such that the mesh grids (7) surround the illuminating device (1) and configured to be equipped with the objects (9); and a set of reflectors including a set of movable side reflectors (11), wherein the reflectors are configured to be arranged such, that they form a resonator surrounding the mesh grids (7) surrounding the illuminating device (1).
COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (France)
LEHIGH UNIVERSITY (USA)
CORNELL UNIVERSITY (USA)
Inventor
Moyle, Nichole
Bremond, Florian
Hui, Chung Yuen
Wu, Haibin
Jagota, Anand
Khripin, Constantine
Abstract
An article of manufacture comprising: (a) a body at least a portion of which is a multi-phase material (MPM) defining a traction surface; (b) the MPM comprising at least first and second zones comprising first and second materials, M1, M2, respectively, at or near the traction surface, the M1 and M2 having first and second Young moduli respectively, the first and second moduli differing by at least a factor of 3; and (c) wherein each of the second zones has a center, and wherein the second zones have a center-to-center radial distribution function having a peak at between 10 μm and 10 mm.
Described herein are apparatus comprising: a first layer comprising a first microfluidic channel; a second layer comprising a second microfluidic channel; and a membrane for culturing cells; along with methods of making and using same.
Systems, apparatuses, and methods for realizing a peak-force scattering scanning near-field optical microscopy (PF-SNOM). Conventional scattering-type microscopy (s-SNOM) techniques uses tapping mode operation and lock-in detections that do not provide direct tomographic information with explicit tip-sample distance. Using a peak force scattering-type scanning near-field optical microscopy with a combination of peak force tapping mode and time-gated light detection, PF-SNOM enables direct sectioning of vertical near-field signals from a sample surface for both three-dimensional near-field imaging and spectroscopic analysis. PF-SNOM also delivers a spatial resolution of 5 nm and can simultaneously measure mechanical and electrical properties together with optical near-field signals.
Augmented or synergized anti-inflammatory constructs are disclosed including anti-inflammatory terpenes and/or vanilloids covalently conjugated to one another so that the activity of the conjugate is greater than the sum of its parts. Also disclosed are methods of improving the potency of an anti-inflammatory terpene or vanilloid by linking it to another anti-inflammatory terpene or vanilloid via a carbamate linkage, where the potency of the conjugate is greater than the sum of its parts.
C07F 7/08 - Compounds having one or more C—Si linkages
A61K 31/405 - Indole-alkanecarboxylic acidsDerivatives thereof, e.g. tryptophan, indomethacin
A61K 31/196 - Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
A61K 47/55 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
A61K 9/00 - Medicinal preparations characterised by special physical form
A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
C07C 69/96 - Esters of carbonic or haloformic acids
C07C 229/42 - Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
C07D 209/28 - 1-(4-Chlorobenzoyl)-2-methyl- indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atomEsters thereof
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA PENN CENTER FOR INNOVATION (USA)
LEHIGH UNIVERSITY (USA)
Inventor
Yang, Shu
Jolly, Jason, Christopher
Wu, Gaoxiang
Jagota, Anand
He, Zhenping
Abstract
The invention concerns adhesives comprising a polymer network capable of conversion between two different elastic modulus states with essentially no residual stress evolved in conversion between the two different elastic modulus states, wherein the polymer network comprises either or both of (i) poly(2-hydroxy ethyl methacrylate) (PHEMA) hydrogel and/or a copolymers thereof, and (ii) a shape memory polymer. The invention also concerns methods of using such adhesives.
Described herein is a 3D-printed scaffold comprising a peptide-polymer conjugate, the peptide-polymer conjugate having the structure: X-Y-Z-Y-X, wherein X is a biologically active peptide, Y is a linker moiety, and Z is a biocompatible and biodegradable polymer.
Described herein are agricultural compositions comprising an adduct of urea comprising: urea; and an inorganic salt; wherein the adduct has an average particle size ranging from about 0.1 microns to about 10 microns.
Integrated photonic chips and related systems and methods suitable for space-division multiplexing optical coherence tomography scanning are disclosed. In one embodiment, the photonic chip comprises a substrate, an optical input port which receives an incident sampling beam from an external light source, a plurality of optical output ports configured to transmit a plurality of sampling beams from the chip to a sample to capture scanned images of the sample, and a plurality of interconnected and branched waveguide channels formed in the substrate. Waveguide channels in a splitter region divide the sampling beam into the plurality of sampling beams at the output ports. Terminal portions of the waveguide channels in a time delay region associated with each output port have different predetermined lengths to create an optical time delay between the sampling beams. In some embodiments, the chip further comprises an interferometer region to create interference patterns.
G02B 6/28 - Optical coupling means having data bus means, i.e. plural waveguides interconnected and providing an inherently bidirectional system by mixing and splitting signals
A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
51.
Additive manufacturing system with tunable material properties
B29C 64/118 - Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
High pressure spatial chemical vapor deposition apparatuses and related process are disclosed for forming thin films on a substrate. An enclosure includes plural process chambers fluidly isolated from each other by radial separating barriers. Each chamber contains a different source gas comprising one or more volatile reactive species. The substrate is supported beneath the chambers on a rotating heated susceptor. Rotation of the susceptor carries the substrate in a path which consecutively exposes the substrate to the volatile reactive species in each process chamber. The gases first mix in the gaseous boundary layer formed adjacent the substrate. A thin film gradually grows in thickness on the substrate with each successive pass and exposure to the volatile reactive species in each of the individual process chambers. The film may be grown at high pressures exceeding 1 atmosphere in some implementations. A modular design includes an outer shell and different interchangeable process inserts.
B01F 15/04 - Forming a predetermined ratio of the substances to be mixed
C23C 14/54 - Controlling or regulating the coating process
C23C 16/455 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for introducing gases into the reaction chamber or for modifying gas flows in the reaction chamber
C23C 16/458 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating characterised by the method used for supporting substrates in the reaction chamber
C23C 16/50 - Chemical coating by decomposition of gaseous compounds, without leaving reaction products of surface material in the coating, i.e. chemical vapour deposition [CVD] processes characterised by the method of coating using electric discharges
A method of making SiC nanowires comprising: (a) mixing silicon powder with a carbon-containing biopolymer and a catalyst at room temperature to form a mixture; and (b) heating said mixture to a pyrolyzing temperature sufficient to react said biopolymer and said silicon power to form SiC nanowires.
Systems and methods presented herein provide for multivariable model predictive control of a multistep plant. In one embodiment, a model predictive controller (MPC) includes a model of the multistep plant. The MPC is operable to linearize at least two steps of the multistep plant into cycle steps based on the model, to process an output signal from the multistep plant, and to independently control the cycle steps based on the output signal to optimize an output of the multistep plant.
G05B 19/418 - Total factory control, i.e. centrally controlling a plurality of machines, e.g. direct or distributed numerical control [DNC], flexible manufacturing systems [FMS], integrated manufacturing systems [IMS] or computer integrated manufacturing [CIM]
G05B 13/04 - Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric involving the use of models or simulators
B01D 53/04 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
Disclosed herein are compound capable of exploiting non-bonding electron densities, for example, cationic open-shell, pi-conjugated bisphenalenyls wherein intermolecular covalent bonding interactions can occur in multiple dimensions. Further disclosed are compositions comprising the disclosed compounds and process for the preparation thereof.
C07C 211/42 - Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing condensed ring systems with six-membered aromatic rings being part of the condensed ring systems
C07D 311/78 - Ring systems having three or more relevant rings
56.
SYSTEM AND METHOD FOR A NON-TAPPING MODE SCATTERING-TYPE SCANNING NEAR-FIELD OPTICAL MICROSCOPY
Systems, apparatuses, and methods for realizing a peak-force scattering scanning near-field optical microscopy (PF-SNOM). Conventional scattering-type microscopy (s-SNOM) techniques uses tapping mode operation and lock-in detections that do not provide direct tomographic information with explicit tip-sample distance. Using a peak force scattering-type scanning near-field optical microscopy with a combination of peak force tapping mode and time-gated light detection, PF-SNOM enables direct sectioning of vertical near-field signals from a sample surface for both three-dimensional near-field imaging and spectroscopic analysis. PF-SNOM also delivers a spatial resolution of 5 nm and can simultaneously measure mechanical and electrical properties together with optical near-field signals.
G01Q 70/00 - General aspects of SPM probes, their manufacture or their related instrumentation, insofar as they are not specially adapted to a single SPM technique covered by group
In one aspect the invention provides a graded refractive index single crystal waveguide having a glass block containing at least one crystal core, the crystal core having a central portion extending along an axis from a first end to a second end; an interface defining a peripheral boundary of the crystal core at a junction of the crystal core and an adjacent portion of the glass block, and a continuous, radially symmetric misorientation transverse to the central portion; wherein the misorientation has a misorientation angle that increases with increasing distance from the central portion towards the interface.
G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
G02B 6/13 - Integrated optical circuits characterised by the manufacturing method
G02F 1/00 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics
G02B 6/122 - Basic optical elements, e.g. light-guiding paths
G02F 1/035 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour based on ceramics or electro-optical crystals, e.g. exhibiting Pockels or Kerr effect in an optical waveguide structure
Described herein are agricultural compositions comprising an adduct of urea comprising: urea; and an inorganic salt; wherein the adduct has an average particle size ranging from about 0.1 microns to about 10 microns.
A61K 47/68 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
A61K 39/40 - AntibodiesImmunoglobulinsImmune serum, e.g. antilymphocytic serum bacterial
Described herein is a 3D-printed scaffold comprising a peptide-polymer conjugate, the peptide-polymer conjugate having the structure: X-Y-Z-Y-X, wherein X is a biologically active peptide, Y is a linker moiety, and Z is a biocompatible and biodegradable polymer.
A61L 27/40 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material
A61L 27/44 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
A61L 27/50 - Materials characterised by their function or physical properties
A61L 27/58 - Materials at least partially resorbable by the body
B29C 47/00 - Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor (extrusion blow-moulding B29C 49/04)
61.
SPACE DIVISION MULTIPLEXING OPTICAL COHERENCE TOMOGRAPHY USING AN INTEGRATED PHOTONIC DEVICE
Integrated photonic chips and related systems and methods suitable for space-division multiplexing optical coherence tomography scanning are disclosed. In one embodiment, the photonic chip comprises a substrate, an optical input port which receives an incident sampling beam from an external light source, a plurality of optical output ports configured to transmit a plurality of sampling beams from the chip to a sample to capture scanned images of the sample, and a plurality of interconnected and branched waveguide channels formed in the substrate. Waveguide channels in a splitter region divide the sampling beam into the plurality of sampling beams at the output ports. Terminal portions of the waveguide channels in a time delay region associated with each output port have different predetermined lengths to create an optical time delay between the sampling beams. In some embodiments, the chip further comprises an interferometer region to create interference patterns.
B29C 70/64 - Shaping composites, i.e. plastics material comprising reinforcements, fillers or preformed parts, e.g. inserts comprising fillers only the filler influencing the surface characteristics of the material, e.g. by concentrating near the surface or by incorporation into the surface by force
63.
ADDITIVE MANUFACTURING SYSTEM WITH TUNABLE MATERIAL PROPERTIES
Augmented or synergized anti-inflammatory constructs are disclosed including anti-inflammatory amino acids covalently conjugated with other anti-inflammatory molecules such as nonsteroidal anti-inflammatory drugs, vanilloids and ketone bodies. Further conjugation with a choline bioisostere or an additional anti-inflammatory moiety further augments the anti-inflammatory activity.
C07D 207/16 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C07D 209/18 - Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
A61K 47/55 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
65.
Contaminants removal with simultaneous desalination using carbon dioxide regenerated hybrid ion exchanger nanomaterials
2 as the sole regenerant for both the hybrid anion exchanger and the weak acid cationic exchanger, thus producing spent regenerant with no externally added chemicals.
B01J 39/07 - Processes using organic exchangers in the weakly acidic form
B01J 47/127 - Ion-exchange processes in generalApparatus therefor characterised by the use of ion-exchange material in the form of ribbons, filaments, fibres or sheets, e.g. membranes in the form of filaments or fibres
In one aspect the invention provides a graded refractive index single crystal waveguide having a glass block containing at least one crystal core, the crystal core having a central portion extending along an axis from a first end to a second end; an interface defining a peripheral boundary of the crystal core at a junction of the crystal core and an adjacent portion of the glass block, and a continuous, radially symmetric misorientation transverse to the central portion; wherein the misorientation has a misorientation angle that increases with increasing distance from the central portion towards the interface.
G02B 6/12 - Light guidesStructural details of arrangements comprising light guides and other optical elements, e.g. couplings of the optical waveguide type of the integrated circuit kind
G02F 1/00 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics
G02F 1/035 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour based on ceramics or electro-optical crystals, e.g. exhibiting Pockels or Kerr effect in an optical waveguide structure
G02B 6/13 - Integrated optical circuits characterised by the manufacturing method
G02B 6/122 - Basic optical elements, e.g. light-guiding paths
A method for growing polarized endometrial cells, said method comprising: (a) disposing endometrial cells on a scaffold, said scaffold comprising a silica-based glass composition, characterized by multi-modal porosity, said scaffold being to define a top side and a bottom side; (b) providing nutrients to said top and bottom sides of said scaffold and an environment to grow polarized endometrial cells on said scaffold.
C12N 5/071 - Vertebrate cells or tissues, e.g. human cells or tissues
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
A61B 17/435 - Gynaecological or obstetrical instruments or methods for reproduction or fertilisation for embryo transplantation
68.
Ductile chord connectors for use in concrete rods in structures
Provided herein are connectors for use in assembling reinforced concrete structures, as well as methods of assembly using the connectors. In one embodiment, the connectors and methods provide for secure and easy connection to the butt end of any rebar rod, as well as attachment of an opposite end to another metal structure. For example, a butt portion of a connector slides over the butt portion of a rebar rod, and can include one or more sidewall openings to allow welding onto rebar that is enclosed within the butt portion of the connector. The opposite second end can include a faceplate for attaching a weld plate, thus permitting a series of connections using connectors and weld plates, among other things. The connectors provide selected properties that differ from the rebar, welds, and weld plates, such as stretch, yield strength, ultimate strength, and transfer of stress and vibration, among other things.
B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
B01D 53/04 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by adsorption, e.g. preparative gas chromatography with stationary adsorbents
B01D 53/32 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by electrical effects other than those provided for in group
H01G 11/06 - Hybrid capacitors with one of the electrodes allowing ions to be reversibly doped thereinto, e.g. lithium ion capacitors [LIC]
H01G 11/00 - Hybrid capacitors, i.e. capacitors having different positive and negative electrodesElectric double-layer [EDL] capacitorsProcesses for the manufacture thereof or of parts thereof
70.
In-situ, self-adjusting stability control of methane-producing anaerobic biological reactors through novel use of ion exchange fibers
An anaerobic biological reactor comprising an anaerobic digester having a chamber configured to receive a microbial suspension, a chamber inlet configured to direct an organic waste stream into the digester, and ion-exchange fibers within the chamber in position to contact and chemically react with microbial suspension received into the chamber. A method for treating organic waste with a methane-producing anaerobic biological reactor comprise providing a methane-producing anaerobic biological reactor comprising an anaerobic digester containing a microbial suspension comprising acetogenic bacteria, methanogenic bacteria and a plurality of ion exchange fibers, introducing organic waste into the anaerobic digester, maintaining the microbial suspension in contact with the organic waste and at least a portion of the plurality of ion-exchange fibers for a period of time and under conditions sufficient to treat the organic waste and produce methane, and removing the treated organic waste and methane from the anaerobic digester.
An apparatus and method of performing sample characterization with an AFM and a pulsed IR laser directed at the tip of a probe of the AFM. The laser pulses are synchronized with the oscillatory drive of the AFM so that a pulse interacts with the tip/sample only selected (e.g., every other) cycles of the oscillation. Nano-mechanical and nano-spectroscopic measurements can be made with sub-50 nm, and even sub-20 nm, resolution.
An apparatus and method of performing sample characterization with an AFM and a pulsed IR laser directed at the tip of a probe of the AFM. The laser pulses are synchronized with the oscillatory drive of the AFM and may only interact with the tip/sample on selected cycles of the oscillation. Peak force tapping mode is preferred for AFM operation. Nano-mechanical and nano-spectroscopic measurements can be made with sub-50 nm, and even sub-20 nm, resolution.
G01N 21/35 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
G01N 21/33 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using ultraviolet light
G01Q 60/24 - AFM [Atomic Force Microscopy] or apparatus therefor, e.g. AFM probes
G01N 29/12 - Analysing solids by measuring frequency or resonance of acoustic waves
73.
Infrared characterization of a sample using oscillating mode
An apparatus and method of performing sample characterization with an AFM and a pulsed IR laser directed at the tip of a probe of the AFM. The laser pulses are synchronized with the oscillatory drive of the AFM and may only interact with the tip/sample on selected cycles of the oscillation. Peak force tapping mode is preferred for AFM operation. Nano-mechanical and nano-spectroscopic measurements can be made with sub-50 nm, and even sub-20 nm, resolution.
G01N 21/35 - Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
74.
Microfluidic concentrator for label-free, continuous nanoparticle processing
Disclosed herein are apparatuses comprising, for example, a microfluidic channel device comprising a main body comprising a channel configured to provide for helical fluid motion of material within the channel; and a temperature control system that applies a temperature gradient to the channel. Methods of making and using the apparatus are also described.
The present invention includes methods of promoting single crystal growth via solid-solid transformation of an appropriate glass, while avoiding the gaseous or liquid phase. In certain embodiments, in the all-solid-state glass-to-crystal transformation of the invention, extraneous nucleation is avoided relative to crystal growth via spatially localized laser heating and optional inclusion of a suitable glass former in the composition. The ability to fabricate patterned single-crystal architecture on a glass surface was demonstrated, providing a new class of micro-structured substrate for low cost epitaxial growth and active planar devices, for example.
Compositions, compounds and methods are described for addressing both toxicity of membrane disruptive anti-microbial agents as well as poor transport of such agents across the blood-brain-barrier (BBB) via the use of molecular appendages including one or more facial amphiphiles. These molecules have in vitro anti-fungal activity that is very similar to that of the native drug but with hemolytic activity and toxicity towards mammalian cells that is greatly reduced.
A61K 47/55 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
A61K 47/48 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
A61K 47/54 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
A process of preparing a glass comprising: (a) heating a mixture of precursor chemicals to a melt temperature to form a melt, the melt being characterized in that quenching the melt at or above a threshold temperature results in a spinodal phase separation, and quenching the melt below the threshold temperature results in a droplet phase separation; and (b) quenching the melt at or above the threshold temperature in a preheated mold to form the glass composition having the spinodal phase separation.
A space-division multiplexing optical coherence tomography apparatus and system is provided. In one embodiment, the system includes a light source, a reference arm, and a sample arm. The sample arm splits the sampling light into a plurality of sampling beams which may be scanned simultaneously onto a surface of a sample. An optical delay may be introduced into the sampling beams before scanning. A plurality of reflected light signals returned from the sample is collected. In one arrangement, the signals may be combined to produce a single reflected light signal. The reflected light signal(s) and a reference signal are combined to produce an interference signal comprising data representative of digitized images captured of the actual object. In one embodiment, a single sample arm may be used for scanning and collecting image data. A related method is also provided.
Provided herein are connectors for use in assembling reinforced concrete structures, as well as methods of assembly using the connectors. In one embodiment, the connectors and methods provide for secure and easy connection to the butt end of any rebar rod, as well as attachment of an opposite end to another metal structure. For example, a butt portion of a connector slides over the butt portion of a rebar rod, and can include one or more sidewall openings to allow welding onto rebar that is enclosed within the butt portion of the connector. The opposite second end can include a faceplate for attaching a weld plate, thus permitting a series of connections using connectors and weld plates, among other things. The connectors provide selected properties that differ from the rebar, welds, and weld plates, such as stretch, yield strength, ultimate strength, and transfer of stress and vibration, among other things.
The present invention includes an anion exchange method that uses sulfate-containing acid mine drainage (AMD), or any sulfate containing water resource, to remove strontium, barium, and/or radium from contaminated water sources, such as but not limited to hydraulic fracturing waste water, flowback, and/or produced water, without requiring any external regenerant. The removal process may be adopted with any waste water or impaired water source containing sulfate anions.
C02F 1/42 - Treatment of water, waste water, or sewage by ion-exchange
C02F 5/02 - Softening water by precipitation of the hardness
B01D 15/36 - Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
B01J 41/14 - Macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
C02F 9/00 - Multistage treatment of water, waste water or sewage
H01L 29/15 - Structures with periodic or quasi periodic potential variation, e.g. multiple quantum wells, superlattices
H01L 21/02 - Manufacture or treatment of semiconductor devices or of parts thereof
H01L 29/20 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only AIIIBV compounds
H01L 29/205 - Semiconductor bodies characterised by the materials of which they are formed including, apart from doping materials or other impurities, only AIIIBV compounds including two or more compounds in different semiconductor regions
82.
CONTROLLING FRICTION CHARACTERISTICS OF RESILIENT MEMBERS USING NEAR-SURFACE MICROSTRUCTURES
COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN (France)
Inventor
Jagota, Anand
Bai, Ying
He, Zhenping
Hui, Chung-Yuen
Levrard, Benjamin
Abstract
Resilient members having near-surface architectures including microstructures for controlling friction are provided. A film-terminated array of fibrils having a sharp film/fibril juncture exhibits an unexpectedly large enhancement of adhesion, static friction and sliding friction. The enhancement is provided against rough indenters. A film-terminated array of elongated ridges and valleys unexpectedly exhibits low adhesion, and an unexpectedly large enhancement of sliding friction. The film-terminated ridge/valley design provides an anisotropic structure with direction-dependent frictional properties. The increase in sliding friction force varies as a function of interfibrillar spacing, and corresponds to a mode in which buckling of the terminal film occurs. The near surface architectures may be designed with varying scales and varying parameters to provide performance characteristics tailored to various applications. By way of example, the film-terminated ridge/valley array may be incorporated in motor vehicles tires to provide low rolling resistance and high sliding friction allow for high-performance braking during vehicle operation.
B32B 27/08 - Layered products essentially comprising synthetic resin as the main or only constituent of a layer next to another layer of a specific substance of synthetic resin of a different kind
B32B 3/08 - Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by features of form at particular places, e.g. in edge regions characterised by added members at particular parts
B32B 3/30 - Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a particular shape of the outline of the cross-section of a continuous layerLayered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a layer with cavities or internal voids characterised by a layer formed with recesses or projections, e.g. grooved, ribbed
83.
Diagnostic system and method for biological tissue analysis
A computer diagnostic system and related method are disclosed for automatically classifying tissue types in an original tissue image captured by an imaging device based on texture analysis. In one embodiment, the system receives and divides the tissue image into multiple smaller tissue block images. A combination of local binary pattern (LBP), average LBP (ALBP), and block-based LBP (BLBP) feature extractions are performed on each tissue block. The extractions generate a set of LBP, ALBP, and BLBP features for each block which are used to classify its tissue type. The classification results are visually displayed in a digitally enhanced map of the original tissue image. In one embodiment, a tissue type of interest is displayed in the original tissue image. In another or the same embodiment, the map displays each of the different tissue types present in the original tissue image.
An optical device includes a transparent substrate and a conductive layer disposed over an upper surface of the transparent substrate. The conductive layer defines at least one groove inwardly extending from an upper surface and includes an aperture that is spaced apart from the at least one groove. An interface between the upper surface of the conductive layer and an ambient medium defines an optical branch along which surface plasmon polariton modes are excited in response to at least partially coherent light being received by the optical device.
G01N 21/45 - RefractivityPhase-affecting properties, e.g. optical path length using interferometric methodsRefractivityPhase-affecting properties, e.g. optical path length using Schlieren methods
G01N 21/01 - Arrangements or apparatus for facilitating the optical investigation
B82Y 20/00 - Nanooptics, e.g. quantum optics or photonic crystals
G01N 21/77 - Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
G02B 6/122 - Basic optical elements, e.g. light-guiding paths
Described herein are perfluoroalkylated zinc compounds having the structure of Formula (I) or Formula (II), which can be used to perfluoroalkylate organic, inorganic and organometallic substrates. Methods of making and using these compounds by reacting zinc or a dialkylzinc compound with a perfluoroalkyl dihalide in a solvent such as tetrahydrofuran, dioxane or diglyme, are also described.
C07C 17/263 - Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
An insulated composite structural panel comprises a first concrete layer, a second concrete layer, and an insulation layer disposed therebetween. One or more shear ties are embedded in the panel. The shear ties include a base portion and a plurality of elongated anchor elements extending from the base portion. A portion of each anchor element extends through the first and second concrete layers and insulation layer. The tie is formed of a material exhibiting ductile elastic-plastic behavior under an applied shear load. In a non-limiting example, the tie may be formed of a fiber reinforced polymer. The tie is constructed and acts to form stable flexural hinges at the interface between the insulation layer and each concrete layer. During a shear load event, portions of the anchor elements within the insulation laterally deform in a ductile manner to keep the structural panel relatively intact.
E04C 2/288 - Building elements of relatively thin form for the construction of parts of buildings, e.g. sheet materials, slabs, or panels characterised by specified materials composed of materials covered by two or more of groups , , , or of materials covered by one of these groups with a material not specified in one of these groups at least one of the materials being insulating composed of insulating material and concrete, stone or stone-like material
E04B 1/76 - Heat, sound or noise insulation, absorption, or reflectionOther building methods affording favourable thermal or acoustical conditions, e.g. accumulating of heat within walls specifically with respect to heat only
E04C 2/04 - Building elements of relatively thin form for the construction of parts of buildings, e.g. sheet materials, slabs, or panels characterised by specified materials of concrete or other stone-like materialBuilding elements of relatively thin form for the construction of parts of buildings, e.g. sheet materials, slabs, or panels characterised by specified materials of asbestos cement
E04B 2/00 - Walls, e.g. partitions, for buildingsWall construction with regard to insulationConnections specially adapted to walls
A oxygen concentrating system comprising an adsorption column having a first end and a second end, a shell enclosing the column and defining a product gas storage space between the column and the shell, a product conduit connecting the product gas storage space to a product output point, a first conduit comprising at least one first valve having at least a first and second configuration, in the first configuration, compressed air flows from the feed point to the first end, and, in the second configuration, waste gas flows from the first end to the waste point, and a second conduit comprising at least one second valve having at least a first and second configuration, in the first configuration, the product gas flows from the product gas storage space to the second end, and, in the second configuration, the product gas flows from the second end to the storage space.
Described herein are apparatus comprising: a first layer comprising a first microfluidic channel; a second layer comprising a second microfluidic channel; and a membrane for culturing cells; along with methods of making and using same.
One aspect of the invention provides a method of controlling execution of a computer program. The method comprises the following runtime steps: parsing code to identify one or more indirect branches; creating a branch ID data structure that maps an indirect branch location to a branch ID, which is the indirect branch's equivalence class ID; creating a target ID data structure that maps a code address to a target ID, which is an equivalence class ID to which the address belongs; and prior to execution of an indirect branch including a return instruction located at an address: obtaining the branch ID associated with the return address from the branch ID data structure; obtaining the target ID associated with an actual return address for the indirect branch from the target ID data structure; and comparing the branch ID and the target ID.
G06F 9/45 - Compilation or interpretation of high level programme languages
G06F 21/53 - Monitoring users, programs or devices to maintain the integrity of platforms, e.g. of processors, firmware or operating systems during program execution, e.g. stack integrity, buffer overflow or preventing unwanted data erasure by executing in a restricted environment, e.g. sandbox or secure virtual machine
G06F 9/455 - EmulationInterpretationSoftware simulation, e.g. virtualisation or emulation of application or operating system execution engines
90.
Conductive doped metal-glass compositions and methods
g). The methods described herein are believed to introducing polarons formed from the trapping of electrons at partially ionized gold atoms. This unique electrical response provides new functionality to this class of nanocomposites. Additionally, increased thermal conductivity can be provided to an otherwise low conductive glass composition using the inventive methods and other subject matter provided herein.
H01C 7/04 - Non-adjustable resistors formed as one or more layers or coatingsNon-adjustable resistors made from powdered conducting material or powdered semi-conducting material with or without insulating material having negative temperature coefficient
C03B 9/00 - Blowing glassProduction of hollow glass articles
C03B 32/00 - Thermal after-treatment of glass products not provided for in groups , e.g. crystallisation, eliminating gas inclusions or other impurities
H01B 1/02 - Conductors or conductive bodies characterised by the conductive materialsSelection of materials as conductors mainly consisting of metals or alloys
C03B 19/02 - Other methods of shaping glass by casting
C03B 25/02 - Annealing glass products in a discontinuous way
C03C 1/00 - Ingredients generally applicable to manufacture of glasses, glazes or vitreous enamels
C03C 4/14 - Compositions for glass with special properties for electro-conductive glass
C03C 14/00 - Glass compositions containing a non-glass component, e.g. compositions containing fibres, filaments, whiskers, platelets, or the like, dispersed in a glass matrix
H01B 1/08 - Conductors or conductive bodies characterised by the conductive materialsSelection of materials as conductors mainly consisting of other non-metallic substances oxides
The present invention includes a novel salt-free water softening method that utilizes an exchange medium (such as a gel exchange polymer, a macroporous exchange polymer, or an inorganic cation exchanger) that is pre-loaded with a polyvalent cation that has low solubility in aqueous phase at nearly neutral pH. The method of the invention does not require use of a sodium salt or mineral acid in the regeneration of the exchange medium.
Described herein are devices for capturing or isolating a biological cell from a sample, the device comprising a capture bed comprising a wave-herringbone surface pattern; and a plurality of nanostructures. Methods of making and using the same are also described.
A pressurized forward osmotic separation process is disclosed. Generally there are two processes described. One process involves the concentration of a target solute in the first solution; the other process involves the extraction of a solvent from a first solution both by a second solution comprising of water and soluble gas or water, soluble gas, and a compound by creating an osmotic concentration gradient across the semi permeable membrane. The first solution is under pressure from an inert gas and the second solution is under pressure from a soluble gas with equal system pressures greater than 1 atmosphere. The increase or decrease of partial pressure of the soluble gas in the second solution increases or decreases the chemical potential of the second solution to achieve different solution properties. The soluble gas may be carbon dioxide and the compound may be magnesium hydroxide.
C02F 1/44 - Treatment of water, waste water, or sewage by dialysis, osmosis or reverse osmosis
B01D 61/00 - Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltrationApparatus, accessories or auxiliary operations specially adapted therefor
A computer diagnostic system and related method are disclosed for automatically classifying tissue types in an original tissue image captured by an imaging device based on texture analysis. The system receives and divides the tissue image into multiple smaller tissue block images. In one non-limiting embodiment, a combination of local binary pattern (LBP) and average local binary pattern (ALBP) extractions are performed on each tissue block. Other texture analysis methods may be used. The extractions generate a set of LBP and ALBP features for each block which are used to classify its tissue type. The classification results are visually displayed in a digitally enhanced map of the original tissue image. In one embodiment, a tissue type of interest is displayed in the original tissue image. In another or the same embodiment, the map displays each of the different tissue types present in the original tissue image.
Described herein are perfiuoroalkylated zinc compounds having the structure of Formula (I) or Formula (II), which can be used to · perfluoroalkylate organic, inorganic and organometallic substrates. Methods of making and using these compounds by reacting zinc or a dialkylzinc compound with a perfluoroalkyl dihalide in a solvent such as tetrahydrofuran, dioxane or diglyme, are also described.
C07C 17/26 - Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
C07C 22/08 - Cyclic compounds containing halogen atoms bound to an acyclic carbon atom having unsaturation in the rings containing six-membered aromatic rings containing fluorine
96.
BRACKISH WATER DESALINATION USING TUNABLE ANION EXCHANGE BED
A process for treating feed water for desalination, the process comprising: (a) removing one or more polyvalent anions from the feed water by feeding the feed water into a bed comprising one or more anion exchange resins under conditions sufficient to exchange the polyvalent ions in the feed water with one or more monovalent anions in the resin; and (b) regenerating the bed by feeding a brine stream into the bed under conditions sufficient to exchange one or more polyvalent anions in the resins with one or more monovalent anions in the brine stream.
A thin film organic photovoltaic device or solar cell in one embodiment includes an organic active bilayer and an ultrathin two-dimensional metallic nanogrid as a transparent conducting electrode which receives incident light. The nanogrid excites surface plasmonic resonances at an interface between the nanogrid and active bilayer from the incident light to enhance photon absorption in the active bilayer below the nanogrid. In another embodiment, spatially separated nanograting electrodes may alternatively be formed by double one-dimensional nanogratings disposed on opposite sides of the organic active bilayer. The spatially separated nanogratings may be oriented perpendicular to each other.
New semiconductor nanoparticles and manufacturing technologies, including novel methods, systems, and compositions, are provided herein. Robust, reproducible production of large amounts of semiconductor nanoparticles, such as quantum dots, from bacterial cultures during continuous growth is provided, without a need for extensive post growth processing or modification. The result is a novel semiconductor of nanoparticle dimensions and quality that is suitable for commercial applications in lighting, display, imaging, diagnostics, photovoltaics and hydrogen generation, for example. In one embodiment, bacterial-based synthesis methods for producing nanocrystal semiconductor quantum dots are provided by aqueous, environmentally friendly media and methods.
C12P 3/00 - Preparation of elements or inorganic compounds except carbon dioxide
B82Y 40/00 - Manufacture or treatment of nanostructures
H01L 51/00 - Solid state devices using organic materials as the active part, or using a combination of organic materials with other materials as the active part; Processes or apparatus specially adapted for the manufacture or treatment of such devices, or of parts thereof
B82B 3/00 - Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
B82Y 5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
99.
Polymer coated sand and methods of manufacture and use
Described herein are systems for manipulating a flowable substance, comprising: a flowable substance; a heating means; a cooling means; and a composition comprising chemically inert particles coated with a stimuli-responsive material. Compositions and methods for using the compositions are also described herein.
Augmented or synergized anti-inflammatory constructs are disclosed including terpenes covalently conjugated with other anti-inflammatory molecules such as nonsteroidal anti-inflammatory drugs, vanilloids, amino acids and polyamines; and anti-inflammatory molecules covalently conjugated with specific amino acids. For the latter, further conjugation with a choline bioisostere further augments the anti-inflammatory activity.