A filter includes an inlet through which a liquid is introduced, an outlet through which the liquid is discharged, a flow path through which the liquid flows from the inlet to the outlet, a first filter portion (for example, an A filter portion) which is a filter portion configured to remove contaminants from the liquid and is disposed in a first flow path that is the flow path, and a second filter portion (a B filter portion to a J filter portion) which is filter portion and is disposed in a second flow path that is the flow path at least partially different from the first flow path, wherein the first flow path and the second flow path have different flow path resistances.
B01D 35/02 - Filters adapted for location in special places, e.g. pipe-lines, pumps, stop-cocks
B01D 29/56 - Filters with filtering elements stationary during filtration, e.g. pressure or suction filters, not covered by groups Filtering elements therefor with multiple filtering elements, characterised by their mutual disposition in series connection
G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
2.
STATE PREDICTION DEVICE, CLASSIFICATION MODEL CREATION DEVICE, STATE PREDICTION METHOD, CLASSIFICATION MODEL CREATION METHOD, AND PROGRAM
This state prediction device predicts, in a flow cytometry method, the state of an inspection specimen provider from a plurality of observation objects for inspection that, as observation objects included in a specimen acquired from a specimen provider, are included in an inspection specimen acquired from the inspection specimen provider. The state prediction device comprises: a signal information acquisition unit that, due to the configuration of structured illumination or the configuration of structured detection, acquires, for each of the plurality of observation objects, signal information indicating a temporal change in the intensity of an electromagnetic wave, which is generated by a light detector that has received an electromagnetic wave modulated by the observation objects existing in a light irradiation area irradiated with illumination light from a light source; and a state prediction unit that, on the basis of a classification model, which has been trained on the relationship between training signal information including signal information for each of training observation objects and the state of a training specimen provider, predicts the state of the inspection specimen provider from inspection signal information including the signal information acquired for each of the plurality of observation objects for inspection.
A classification model that outputs identification information indicating whether or not a particle has specific morphological characteristics when waveform data is input is generated by training using training data including first waveform data that is obtained by irradiating light to particles contained in a first sample and having specific morphological characteristics and indicates morphological characteristics of the particles, information indicating that the first waveform data has been obtained from particles contained in the first sample, second waveform data indicating morphological characteristics of unspecified particles contained in a second sample, information indicating that the second waveform data has been obtained from particles contained in the second sample, and a positive rate that is the proportion of particles having the specific morphological characteristics.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Computer software for separating, measuring and analyzing
cells; computer software for cell analyzer; computer
software for blood analyzer; computer software for flow
cytometer; computer software for cell separator; computer
software for cell sorter; computer software, recorded;
computer programs, recorded; computer software applications,
downloadable; downloadable computer software; computer
programs, downloadable; application software; cell analyzer
for laboratory use; blood analyzer for laboratory use; flow
cytometer for laboratory use; cell separator for laboratory
use; cell sorter for laboratory use; cell analyzer, not for
medical purposes; bioreactors for cell culture; laboratory
apparatus and instruments; photographic, cinematographic and
optical apparatus and instruments; measuring and testing
machines and instruments; electrical communication machines
and instruments; personal digital assistants; computer
hardware; computer software; data storage apparatus; data
processing equipment; downloadable image files; electronic
publications [downloadable] provided from databases or the
Internet. Providing online non-downloadable computer software for
separating, measuring and analyzing cells; providing online
non-downloadable computer software for cell analyzer;
providing online non-downloadable computer software for
blood analyzer; providing online non-downloadable computer
software for flow cytometer; providing online
non-downloadable computer software for cell separator;
providing online non-downloadable computer software for cell
sorter; providing online non-downloadable computer software;
software as a service [SaaS]; platform as a service [PaaS];
providing temporary use of online non-downloadable software;
server hosting; consulting services in the field of cloud
computing; rental of server memory space; electronic data
storage; design and development of computer hardware and
software; design, development and programming of computer
software; cell separation laboratory services; cell
detection laboratory services; cell analysis laboratory
services; research services in the field of proteins,
antibodies, microorganisms and cells; scientific services
relating to the isolation and cultivation of human tissues
and cells; research and development services in the field of
cytology; stem cell research; scientific research for
medical purposes in the field of cancerous diseases;
development of pharmaceutical preparations and medicines;
medical research; design and development of medical
technology; testing, inspection and research services in the
fields of pharmaceuticals, cosmetics and foodstuffs;
scientific research and development; scientific research,
testing and analysis services; industrial research, testing
and analysis services; product quality testing services;
design and development of diagnostic apparatus; product
design and development services; design services; computer
programming in the medical field; creation, design,
development, and maintenance of websites; testing and
research services relating to machines, apparatus and
instruments; rental of measuring apparatus; rental of
computer hardware and computer software; rental of
laboratory apparatus and instruments.
5.
FLOW CYTOMETER, DISCRIMINATION METHOD, AND PROGRAM
A flow cytometer includes: a flow channel allowing a measurement object not labeled with a fluorescent dye to flow along with a fluid; a light source emitting illumination light; an illumination optical system irradiating the measurement object flowing in the flow channel with the illumination light emitted from the light source as a spotlight which is illumination light condensed in at least one of a width direction and a depth direction of the flow channel at an irradiation position in the flow channel; a light detector detecting fluorescence emitted from a specific molecule of the measurement object in response to irradiation with the spotlight via the illumination optical system; a detection optical system allowing the fluorescence to propagate to the light detector; and a discrimination unit configured to discriminate whether the measurement object is a target measurement object based on information of the fluorescence detected by the light detector.
A flow cytometer includes a microfluidic device, a light source, a photodetector that detects, in time series, the intensity of signal light emitted from an observation object when the observation object flowing through a flow path is irradiated with illumination light, an information generation device that generates optical information indicating a structure of the observation object based on the intensity of the signal light, an arithmetic device, and a flow path position control device, wherein the arithmetic device includes a signal intensity acquiring unit that acquires electronic data of temporal changes in the intensity of the signal light detected based on a detection position predetermined in the flow path to detect the depth position in the flow path where the observation object passes through the flow path, a scan unit that performs a scan process to move the flow path in the depth direction and acquire the electronic data at different depth positions, a position calculation unit that calculates the depth position based on the electronic data, and an output unit that outputs position information indicating the depth position calculated by the position calculation unit.
A flow cytometer includes a microfluidic device, a light source, a photodetector, an information generation device, a calculation device, and a flow path position control device. In the microfluidic device, a first position detection line is arranged on a flow path, a second position detection line is arranged with a portion overlapping the first position detection line in a width direction, and a position detection distance, which is a distance between the first position detection line and the second position detection line in a length direction of the flow path, changes with a position in the width direction. The calculation device includes a time difference calculation unit configured to calculate a time difference between the time when the photodetector has detected a peak intensity of an optical signal at any one detection position on the first position detection line and the time when the photodetector has detected the peak intensity of the optical signal at any one detection position on the second position detection line and a position calculation unit configured to calculate the position of the observation object in the width direction on the basis of the time difference and a corresponding relationship between the time difference and the position in the width direction.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Downloadable computer software for separating, measuring and analyzing cells; downloadable computer software for operating cell analyzer; downloadable computer software for operating blood analyzer; downloadable computer software for operating flow cytometer; downloadable computer software for operating cell separator; downloadable computer software for operating cell sorter; cell analyzer for laboratory use, namely, flow cytometers for cell analysis; blood analyzer for laboratory use; flow cytometer for laboratory use; cell separator for laboratory use, namely, cytometers; cell sorter, namely, cytometers for sorting cells for laboratory use; cell analyzer, namely, cytometers, not for medical purposes; bioreactor for cell culturing; smartphones; personal digital assistants; computer hardware; computer software for use with medical technology, namely, downloadable computer software for measuring and analyzing cells; data storage apparatus in the nature of memory media for storing information; data processing equipment; downloadable image files containing morphological information of cells; downloadable electronic publications in the nature of books in the field of cells provided from databases or the Internet Providing online non-downloadable computer software for separating, measuring and analyzing cells; providing online non-downloadable computer software for operating cell analyzer; providing online non-downloadable computer software for operating blood analyzer; providing online non-downloadable computer software for operating flow cytometer; providing online non-downloadable computer software for operating cell separator; providing online non-downloadable computer software for operating cell sorter; providing online non-downloadable computer software for separating, measuring and analyzing cells in the field of medical technology or scientific technology; software as a service (SaaS) featuring software for separating, measuring and analyzing cells; platform as a service (PaaS) featuring computer software platforms for separating, measuring and analyzing cells; providing temporary use of online non-downloadable software for separating, measuring and analyzing cells; server hosting; consulting services in the field of cloud computing; rental of server memory space; electronic data storage; design and development of computer hardware and software; design, development and programming of computer software; cell separation laboratory services for scientific research purposes; cell detection laboratory services for scientific research purposes; cell analysis laboratory services for scientific research purposes; scientific research services in the field of proteins, antibodies, microorganisms and cells; scientific services relating to the isolation and cultivation of human tissues and cells, namely, scientific research services; research and development services in the field of cytology; stem cell research services; scientific research for medical purposes in the field of cancerous diseases; development of pharmaceutical preparations and medicines; medical research; scientific research and development; product quality testing services; design and development of diagnostic apparatus; computer programming in the medical field; rental of computer hardware; rental of computer software for analyzing cells; rental of computers; rental of laboratory apparatus and instruments
9.
FLOW CYTOMETER, IMAGING DEVICE, POSITION DETECTION METHOD, AND PROGRAM
A flow cytometer includes a microfluidic device, a light source, a photodetector, an information generation device, a calculation device, and a flow path position control device. In the microfluidic device, a first position detection line is arranged on a flow path, a second position detection line is arranged with a portion overlapping the first position detection line in a width direction, and a position detection distance, which is a distance between the first position detection line and the second position detection line in a length direction of the flow path, changes with a position in the width direction. The calculation device includes a time difference calculation unit configured to calculate a time difference between the time when the photodetector has detected a peak intensity of an optical signal at any one detection position on the first position detection line and the time when the photodetector has detected the peak intensity of the optical signal at any one detection position on the second position detection line and a position calculation unit configured to calculate the position of the observation object in the width direction on the basis of the time difference and a corresponding relationship between the time difference and the position in the width direction.
In a sample channel through which flows a sample flow containing a measurement sample, this microchannel comprises: a height direction rectification part including a high ceiling part having a higher in-channel ceiling height than in an upstream channel, and a low ceiling part disposed downstream of the high ceiling part and having a lower in-channel ceiling height than the high ceiling part; and a width direction rectification part which is disposed downstream of the height direction rectification part, in which the in-channel ceiling height is equal to or less than the ceiling height of the low ceiling part, and in which sheath liquid inflow paths, that allow a sheath liquid to flow in from both side surface directions of the channel, merge.
Systems and methods are provided to implement classification of objects, based on sensor data regarding the objects, without labels assigned to the sensor data. A system can include one or more processors. The one or more processors can retrieve sensor data regarding an object. The one or more processors can apply the sensor data as input to a classification model to cause the classification model to determine a classification of the object. The classification model can be configured based on training data that includes a plurality of clusters generated by dimensionality reduction of example data regarding example objects. At least one cluster of the plurality of clusters can be associated with the classification. The one or more processors can output the classification of the object.
Systems and methods are provided to implement classification of objects, based on sensor data regarding the objects, in a manner that addresses variations in the sensor data, including measurement variables among the objects. A system can include one or more processors to retrieve sensor data regarding an object that is at least one of cellular material from one or more cells, nucleic acid material, biological material, or chemical material. The one or more processors can apply the sensor data as input to a classifier to cause the classifier to determine a classification of the object, the classifier configured based on feature data from a first example of object data and a second example of object data associated with at least one of a different time of detection or a different subject than the first example.
Systems and methods are provided to implement classification of objects, based on sensor data regarding the objects, without labels assigned to the sensor data. A system can include one or more processors. The one or more processors can retrieve sensor data regarding an object. The one or more processors can apply the sensor data as input to a classification model to cause the classification model to determine a classification of the object. The classification model can be configured based on training data that includes a plurality of clusters generated by dimensionality reduction of example data regarding example objects. At least one cluster of the plurality of clusters can be associated with the classification. The one or more processors can output the classification of the object.
Systems and methods are provided to implement classification of objects, based on sensor data regarding the objects, in a manner that addresses variations in the sensor data, including measurement variables among the objects. A system can include one or more processors to retrieve sensor data regarding an object that is at least one of cellular material from one or more cells, nucleic acid material, biological material, or chemical material. The one or more processors can apply the sensor data as input to a classifier to cause the classifier to determine a classification of the object, the classifier configured based on feature data from a first example of object data and a second example of object data associated with at least one of a different time of detection or a different subject than the first example.
An observation chip 1 includes: a plurality of substrates 10 stacked in a thickness direction Z of the substrates; a first channel 25 extending along a first axis O1 along the substrates; a surrounding channel 30 surrounding the first channel all around in a cross section orthogonal to the first axis in the first channel from an end of the first channel to an overall merging point P2 of the first channel, integrated with the first channel, and forming a second channel 55 that extends along a second axis O2 along the substrates; and an observation section 60 provided on a side farther away from the first channel than the overall merging point in the second channel, and transmitting electromagnetic waves from outside to the second channel. A length of the second channel in the thickness direction is constant from the overall merging point to the observation section.
A filter according to the present invention comprises: an inlet into which a liquid flows; an outlet from which the liquid flows out; a flow path through which the liquid flows from the inlet to the outlet; a first filter section (for example, filter section A) which is part of a filter section capable of removing contaminants from the liquid, and is disposed in a first flow path which constitutes the abovementioned flow path; and second filter sections (filter section B to filter section J) which are part of the abovementioned filter section and are disposed in a second flow path which is at least partially different from the first flow path, wherein the first flow path and the second flow path have different flow resistances.
An optical element according to the present invention imparts a bright spot pattern in the context of a measurement method that involves radiating illumination light at a moving measurement target and detecting modulated light from the measurement target at which the illumination light was radiated, wherein a bright spot pattern is imparted to the illumination light or the modulated light to detect morphological information about the measurement target as optical information. The optical element has a plurality of regions that have different optical characteristics. The optical characteristics are distributed over the plurality of regions in accordance with the bright spot pattern. The bright spot pattern includes at least two partial patterns that are arranged at different positions in the movement direction of the measurement target. At least one of the partial patterns is based on a Fourier basis.
First waveform data, which indicates the morphological characteristics of a particle and is obtained by emitting light to the particle, and a photographic image obtained by photographing the particle are acquired. A first trained model that outputs a particle image when waveform data is input is generated by training using first training data including the first waveform data and the photographic image. Second waveform data is input to the first trained model. Classification information indicating a classification into which the particle is classified according to the morphological characteristics is acquired in association with the particle image output from the first trained model. Data including the second waveform data and the classification information is stored as second training data for training a second trained model that outputs classification information when waveform data is input.
G01N 15/1433 - Signal processing using image recognition
G01N 15/149 - Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
G06V 10/764 - Arrangements for image or video recognition or understanding using pattern recognition or machine learning using classification, e.g. of video objects
This flow cytometer comprises: a light source; a microfluid device; an illumination optical system that radiates illumination light generated by the light source to a light irradiation region of a flow channel; a photodetector that detects modulated light from an observation object irradiated by the illumination light in the light irradiation region; a detection optical system that guides modulated light from the observation object irradiated by the illumination light to the photodetector; and an information generating unit that generates identification information for determining the observation object, on the basis of time series optical information that indicates a time series of the intensity of the modulated light detected by the photodetector, two or more wavelengths of light being included in the illumination light generated by the light source, at least one of the illumination optical system and the detection optical system having a spatial optical modulation element that imparts a luminance pattern to each of the two or more wavelengths of light, and the photodetector detecting, independently for each wavelength, modulated light from the observation object irradiated by the illumination light to which a luminance pattern has been imparted by the spatial optical modulation element, or modulated light obtained by imparting of a luminance pattern by the spatial optical modulation element to the modulated light from the observation object irradiated by the illumination light.
09 - Scientific and electric apparatus and instruments
Goods & Services
Cell analyzer for laboratory use; blood analyzer for
laboratory use; flow cytometer for laboratory use; cell
separator for laboratory use; cell sorter for laboratory
use; cell analyzer, not for medical purposes; bioreactors
for cell culture; laboratory apparatus and instruments;
photographic, cinematographic and optical apparatus and
instruments; measuring and testing machines and instruments;
electrical communication machines and instruments;
smartphones; personal digital assistants; computer hardware;
computer software; data storage apparatus; data processing
equipment; downloadable image files; electronic publications
[downloadable] provided from databases or the Internet.
21.
Classification Model Generation Method, Particle Determination Method, and Recording Medium
In the classification model generation method, for each particle contained in a first sample containing a mixture of particles having specific morphological characteristics and other particles and a second sample that does not contain particles having the specific morphological characteristics but contains only the other particles, observation data indicating a result of observing the particle is acquired. By training using training data including the observation data and information indicating whether the observation data has been obtained from a particle contained in the first sample or the second sample, a classification model is generated that outputs discrimination information indicating whether or not a particle has the specific morphological characteristics when the observation data indicating a result of observing the particle is input.
G01N 15/01 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
A flow cytometer includes: a microfluidic device; a light source that irradiates illumination light toward an observation object flowing through a flow path; an illumination optical system that shapes the illumination light irradiated by the light source into an illumination light of which a length in a length direction of the flow path is equal to or greater than a length in a width direction of the flow path at an irradiation position of the flow path and irradiates the shaped illumination light; a mask for structured detection that has a binary pattern of transmitting portions and blocking portions; an imaging optical system that images scattered light emitted from the observation object on the mask for structured detection by irradiation of the illumination light shaped by the illumination optical system; and a photodetector that detects the scattered light transmitted through the transmitting portions of the mask for structured detection, wherein a propagation path of direct light, which has been transmitted through the observation object, of the illumination light shaped by the illumination optical system and a propagation path of the scattered light emitted from the observation object until the scattered light is detected by the photodetector are spatially separated from each other by the illumination optical system and the imaging optical system.
An acoustic focusing chip is irradiated with ultrasonic waves from an acoustic element P. A flow path having an inlet and an outlet is formed inside of a plate body along a plate surface. A region proximate to the inlet of the flow path of the plate body is set as an ultrasonic wave application region for receiving irradiation of the ultrasonic waves. The acoustic element is arranged on the plate surface in the ultrasonic wave application region. A reflective portion capable of reflecting the ultrasonic waves toward the flow path is formed along the flow path in the ultrasonic wave application region. Thereby, the flow focusing ability, heat dissipation, and strength retention can be cost-effectively improved with a simple configuration.
Disclosed is an optical system including: a light source configured to emit light; an irradiation optical system including a diffractive optical element on which the light is incident, the irradiation optical system being configured to apply illumination light in which a plurality of diffracted lights generated by the diffractive optical element are distributed; a flow cell in which a sample containing cells is caused to flow to a position at which the illumination light is applied by the irradiation optical system; and a light receiver configured to receive light generated from each cell flowing in the flow cell, upon application of the illumination light by the irradiation optical system. The illumination light includes zero-order diffracted light whose relative intensity relative to another diffracted light is not greater than 10 times. The irradiation optical system applies the illumination light to a position through which the cell in the flow cell passes.
The present disclosure provides methods and systems for ghost cytometry (GC), which may be used to produce an image of an object without using a spatially resolving detector. This may be used to perform image-free ultrafast fluorescence “imaging” cytometry, based on, for example, a single pixel detector. Spatial information obtained from the motion of cells relative to a patterned optical structure may be compressively converted into signals that arrive sequentially at a single pixel detector. Combinatorial use of the temporal waveform with the intensity distribution of the random or pseudo-random pattern may permit computational reconstruction of cell morphology. Machine learning methods may be applied directly to the compressed waveforms without image reconstruction to enable efficient image-free morphology-based cytometry. Image-free GC may achieve accurate and high throughput cell classification as well as selective sorting based on cell morphology without a specific biomarker, which have been challenging using conventional flow cytometers.
This micro flow channel comprises, in a sample flow channel through which a sample flow including a measurement sample flows: a height-direction flow streamlining unit having a high ceiling part in which the ceiling height in the flow channel is higher than the ceiling height in the flow channel upstream thereof and a low ceiling part which is disposed downstream of the high ceiling part and in which the ceiling height in the flow channel is lower than the ceiling height in the high ceiling part; and a width-direction flow streamlining unit which is disposed downstream of the height-direction flow streamlining unit, in which the ceiling height in the flow channel is higher than the ceiling height in the low ceiling part, and which has a first sheath liquid flow-in part into which a first sheath liquid flows from both lateral surface directions of the flow channel.
09 - Scientific and electric apparatus and instruments
Goods & Services
Cell analyzer for laboratory use; blood analyzer for
laboratory use; flow cytometer for laboratory use; cell
separator for laboratory use; cell sorter for laboratory
use; cell analyzer, not for medical purposes; bioreactors
for cell culture; laboratory apparatus and instruments;
photographic, cinematographic and optical apparatus and
instruments; measuring and testing machines and instruments;
electrical communication machines and instruments;
smartphones; personal digital assistants; computer hardware;
computer software; data storage apparatus; data processing
equipment; downloadable image files; electronic publications
[downloadable] provided from databases or the Internet.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Cell analyzer for laboratory use; blood analyzer for
laboratory use; flow cytometer for laboratory use; cell
separator for laboratory use; cell sorter for laboratory
use; cell analyzer, not for medical purposes; bioreactors
for cell culture; laboratory apparatus and instruments;
photographic, cinematographic and optical apparatus and
instruments; measuring and testing machines and instruments;
downloadable image files; electronic publications
[downloadable] provided from databases or the Internet. Cell separation laboratory services; cell detection
laboratory services; cell analysis laboratory services;
research services in the field of proteins, antibodies,
microorganisms and cells; scientific services relating to
the isolation and cultivation of human tissues and cells;
research and development services in the field of cytology;
stem cell research; scientific research for medical purposes
in the field of cancerous diseases; development of
pharmaceutical preparations and medicines; medical research;
research and development of medical technology; testing,
inspection and research services in the fields of
pharmaceuticals, cosmetics and foodstuffs; scientific
research and development; scientific research, testing and
analysis services; industrial research, testing and analysis
services; product quality testing services; design and
development of diagnostic apparatus; product design and
development services; design services; computer programming
in the medical field; creation, design, development, and
maintenance of websites; testing and research services
relating to machines, apparatus and instruments; rental of
measuring apparatus; rental of laboratory apparatus and
instruments.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Cell analyzer for laboratory use, namely, cytometers for cell analysis; research laboratory analyzers for analyzing blood for laboratory use; flow cytometer for laboratory use; cell separator for laboratory use, namely, cytometers; cell sorter, namely, cytometers for sorting cells for laboratory use; cell analyzer, namely, cytometers not for medical purposes; bioreactor for cell culturing; downloadable image files containing morphological information of cells; downloadable electronic publications in the nature of books in the field of cells provided from databases or the Internet Cell separation laboratory services for scientific research purposes; cell detection laboratory services for scientific research purposes; cell analysis laboratory services for scientific research purposes; scientific research services in the field of proteins, antibodies, microorganisms and cells; scientific services relating to the isolation and cultivation of human tissues and cells, namely, scientific research services; research and development services in the field of cytology; stem cell research services; scientific research for medical purposes in the field of cancerous diseases; development of pharmaceutical preparations and medicines; medical research; scientific research and development; product quality testing services; scientific product design and development of diagnostic apparatus; computer programming in the medical field; rental of laboratory apparatus and instruments
This flow cytometer comprises: a flow path through which a measurement object unlabelled with a fluorescent dye flows together with a fluid; a light source that emits an illumination light; an illumination optical system that emits, as a spot light, the illumination light emitted by the light source onto the measurement object flowing through the flow path, the spot light being illumination light concentrated in the width direction and/or the depth direction of the flow path at an illumination position on the flow path; a light detector that detects fluorescence emitted from molecules uniquely present in the measurement object, through emission thereon of the spot light by the illumination optical system; a detection optical system that propagates the fluorescence to the light detector; and a determination unit that determines whether the measurement object is a target object on the basis of information of the fluorescence detected by the light detector.
A flow cytometer includes: a light source; a microfluidic device; a photodetector; an information generation device which generates optical information indicating a morphology of an observation target on the basis of optical signal intensity; and a spatial light modulation unit which is installed on an optical path between the light source and the photodetector and structures any one of illumination light irradiated from the light source toward the flow path and signal light from the observation target. In the flow path provided with the microfluidic device, a plurality of optical signal detection positions are arranged linearly at equal intervals in a predetermined direction of the flow path by structuring the illumination light or the signal light and a plurality of trigger signal detection positions for detecting a trigger signal by which the information generation device starts the generation of the optical information are arranged to be separated by the same predetermined distance in a length direction of the flow path while respectively corresponding to the plurality of optical signal detection positions.
09 - Scientific and electric apparatus and instruments
Goods & Services
Cell analyzer for laboratory use, namely, cytometers for cell analysis; blood analyzer for laboratory use; flow cytometer for laboratory use; cell analyzer, namely, cytometers, not for medical purposes
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Cell analyzer for laboratory use; blood analyzer for
laboratory use; flow cytometer for laboratory use; cell
separator for laboratory use; cell sorter for laboratory
use; cell analyzer, not for medical purposes; bioreactors
for cell culture; laboratory apparatus and instruments;
photographic, cinematographic and optical apparatus and
instruments; measuring and testing machines and instruments;
electrical communication machines and instruments;
smartphones; personal digital assistants; computer hardware;
computer software; data storage apparatus; data processing
equipment; downloadable image files; electronic publications
[downloadable] provided from databases or the Internet. Cell separation laboratory services; cell detection
laboratory services; cell analysis laboratory services;
research services in the field of proteins, antibodies,
microorganisms and cells; scientific services relating to
the isolation and cultivation of human tissues and cells;
research and development services in the field of cytology;
stem cell research; scientific research for medical purposes
in the field of cancerous diseases; development of
pharmaceutical preparations and medicines; medical research;
research and development of medical technology; testing,
inspection and research services in the fields of
pharmaceuticals, cosmetics and foodstuffs; scientific
research and development; scientific research, testing and
analysis services; industrial research, testing and analysis
services; product quality testing services; design and
development of diagnostic apparatus; product design and
development services; design services; computer programming
in the medical field; creation, design, development, and
maintenance of websites; testing and research services
relating to machines, apparatus and instruments; rental of
measuring apparatus; rental of computer hardware and
computer software; rental of computers; rental of laboratory
apparatus and instruments.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Cell analyzer for laboratory use; blood analyzer for
laboratory use; flow cytometer for laboratory use; cell
separator for laboratory use; cell sorter for laboratory
use; cell analyzer, not for medical purposes; bioreactors
for cell culture; laboratory apparatus and instruments;
photographic, cinematographic and optical apparatus and
instruments; measuring and testing machines and instruments;
electrical communication machines and instruments;
smartphones; personal digital assistants; computer hardware;
computer software; data storage apparatus; data processing
equipment; downloadable image files; electronic publications
[downloadable] provided from databases or the Internet. Cell separation laboratory services; cell detection
laboratory services; cell analysis laboratory services;
research services in the field of proteins, antibodies,
microorganisms and cells; scientific services relating to
the isolation and cultivation of human tissues and cells;
research and development services in the field of cytology;
stem cell research; scientific research for medical purposes
in the field of cancerous diseases; development of
pharmaceutical preparations and medicines; medical research;
research and development of medical technology; testing,
inspection and research services in the fields of
pharmaceuticals, cosmetics and foodstuffs; scientific
research and development; scientific research, testing and
analysis services; industrial research, testing and analysis
services; product quality testing services; design and
development of diagnostic apparatus; product design and
development services; design services; computer programming
in the medical field; creation, design, development, and
maintenance of websites; testing and research services
relating to machines, apparatus and instruments; rental of
measuring apparatus; rental of computer hardware and
computer software; rental of computers; rental of laboratory
apparatus and instruments.
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Cell analyzer for laboratory use, namely, flow cytometers for cell analysis; blood analyzer for laboratory use; flow cytometer for laboratory use; cell separator for laboratory use, namely, cytometers; cell sorter, namely, cytometers for sorting cells for laboratory use; cell analyzer, namely, cytometers, not for medical purposes; bioreactor for cell culturing; smartphones; personal digital assistants; computer hardware; computer software for use with medical technology, namely, downloadable computer software for measuring and analyzing cells; data storage apparatus in the nature of memory media for storing information; data processing equipment; downloadable image files containing morphological information of cells; downloadable electronic publications in the nature of books in the field of cells provided from databases or the Internet Cell separation laboratory services for scientific research purposes; cell detection laboratory services for scientific research purposes; cell analysis laboratory services for scientific research purposes; scientific research services in the field of proteins, antibodies, microorganisms and cells; scientific services relating to the isolation and cultivation of human tissues and cells, namely, scientific research services; research and development services in the field of cytology; stem cell research services; scientific research for medical purposes in the field of cancerous diseases; development of pharmaceutical preparations and medicines; medical research; scientific research and development; product quality testing services; design and development of diagnostic apparatus; computer programming in the medical field; rental of computer hardware; rental of computer software for analyzing cells; rental of computers; rental of laboratory apparatus and instruments
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Cell analyzer for laboratory use, namely, flow cytometers for cell analysis; blood analyzer for laboratory use; flow cytometer for laboratory use; cell separator for laboratory use, namely, cytometers; cell sorter, namely, cytometers for sorting cells for laboratory use; cell analyzer, namely, cytometers, not for medical purposes; bioreactor for cell culturing; smartphones; personal digital assistants; computer hardware; computer software for use with medical technology, namely, downloadable computer software for measuring and analyzing cells; data storage apparatus in the nature of memory media for storing information; data processing equipment; downloadable image files containing morphological information of cells; downloadable electronic publications in the nature of books in the field of cells provided from databases or the Internet Cell separation laboratory services for scientific research purposes; cell detection laboratory services for scientific research purposes; cell analysis laboratory services for scientific research purposes; scientific research services in the field of proteins, antibodies, microorganisms and cells; scientific services relating to the isolation and cultivation of human tissues and cells, namely, scientific research services; research and development services in the field of cytology; stem cell research services; scientific research for medical purposes in the field of cancerous diseases; development of pharmaceutical preparations and medicines; medical research; scientific research and development; product quality testing services; design and development of diagnostic apparatus; computer programming in the medical field; rental of computer hardware; rental of computer software for analyzing cells; rental of computers; rental of laboratory apparatus and instruments
This flow cytometer comprises: a microfluidic device; a light source that emits illumination light toward an observation target object flowing through a flow path; an illumination optical system that shapes the illumination light emitted by the light source into illumination light having a longitudinal-direction length of the flow path that is equal to or greater than a width-direction length of the flow path at the irradiation position in the flow path, and emits the shaped illumination light; a structured detection mask having binary patterns of transmission portions and blocking portions; an image-forming optical system that causes scattered light emitted from the observation target object by irradiation with the illumination light shaped by the illumination optical system to form an image on the structured detection mask; and an optical detector that detects scattered light which has been transmitted through the transmissive portions of the structured detection mask. The propagation path of direct light transmitted through the observation target object, among the illumination light shaped by the illumination optical system, and the propagation path until the scattered light emitted from the observation target object is detected by the optical detector are spatially divided by the illumination optical system and the image-forming optical system.
This flow cytometer includes a flow path through which an observation object flows with a fluid; an optical illumination system including a spatial optical modulation device, and a first optical element; and an optical detection system including a first light detector, wherein the optical illumination system further includes a first spatial filter disposed in a first optical path between a light source and an image position of light imaged in the flow path by the first optical element and having a first region which hinders traveling of light emitted from the light source towards the observation object, the optical detection system further includes a second light detector disposed in a second optical path between the first light detector and the image position and having a second region which directs the light modulated by the observation object towards the first light detector, and the position of the first region and the position of the second region are in a substantially optically conjugate relationship.
G01N 15/01 - Investigating characteristics of particlesInvestigating permeability, pore-volume or surface-area of porous materials specially adapted for biological cells, e.g. blood cells
Provided are a classification model generation method, a particle determination method, a computer program, and an information processing device for facilitating the discrimination of particles having a specific morphological feature. With the classification model generation method, observation data is acquired, the observation data representing results obtained by observing respective particles contained in a first sample in which particles having a specific morphological feature and other particles are mixed and in a second sample comprising the other particles and not containing the particles having the specific morphological feature, and through learning using training data that includes the observation data and information indicating whether the observation data was obtained from particles contained in the first sample or from particles contained in the second sample, a classification model is generated in a case in which observation data representing results obtained by observing particles has been input, the classification model outputting discrimination information indicating whether particles have the specific morphological feature.
G01N 15/14 - Optical investigation techniques, e.g. flow cytometry
C12M 1/00 - Apparatus for enzymology or microbiology
C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor
The present invention provides a classification model generation method, a particle classification method, a computer program, and an information processing device which are for classifying particles using, as training data, waveform data representing a specified morphological feature and waveform data representing an unspecified morphological feature. The present invention generates a classification model that outputs determination information indicating whether or not particles have a specified morphological feature when waveform data is input, by learning using training data including: first waveform data representing a morphological feature of particles obtained by emitting light to particles which are included in a first sample and which have the specified morphological feature; information indicating that the first waveform data has been obtained from the particles which are included in the first sample; second waveform data representing a morphological feature of unspecified particles which are included in a second sample; information indicating that the second waveform data has been obtained from the particles which are included in the second sample; and the positive rate which is the proportion of particles having the specified morphological feature.
This acoustic focusing chip is irradiated with ultrasonic waves from an acoustic element P, wherein: a flow path having an inlet and an outlet is formed inside a plate body along a plate surface; an area proximate to the inlet of the flow path of the plate body is set as an ultrasonic wave application area that receives irradiation of ultrasonic waves; an acoustic element is disposed on the plate surface in the ultrasonic wave application area; and in the ultrasonic wave application area, a reflective part that can reflect ultrasonic waves toward the flow path is formed along the flow path, thereby making it possible to improve the flow focusing ability, heat dissipation, and strength retention with a simple, affordable configuration.
A flow cell of the flow cytometer of the present invention includes: a sample flow path through which a sample fluid containing a sample flows; and a sample fluid supply portion which communicates with an upstream end of the sample flow path in the sample fluid flow direction and supplies the sample fluid to the sample flow path, wherein the sample fluid supply portion includes a plurality of sample opening portions which supply a sample fluid to the sample flow path, a cleaning liquid supply opening portion to which a second tube is connectable and which supplies a cleaning liquid for cleaning the sample fluid supply portion, and a cleaning liquid discharge opening portion to which a first tube is connectable and which discharges the cleaning liquid from the sample fluid supply portion.
An observation device includes an illumination optical system and an observation optical system. The illumination optical system includes a light source and an aperture member. The observation optical system includes an objective lens, an optical structure, and a detector. The optical structure is disposed at a first position which is the position conjugate with the aperture member. The optical structure includes a blocking portion that blocks light and a transmitting portion that transmits light, the blocking portion having a shape including the shape of an image of an aperture of the aperture member which is formed on the optical structure. The detector detects dark-field light passing through the optical structure.
DATA GENERATION METHOD, TRAINED MODEL GENERATION METHOD, TRAINED MODEL, PARTICLE CLASSIFICATION METHOD, COMPUTER PROGRAM, AND INFORMATION PROCESSING DEVICE
Provided are a data generation method, a trained model generation method, a trained model, a particle classification method, a computer program, and an information processing device that enable waveform data of a particle and a feature of the particle to be associated with one another. According to the present invention: first waveform data representing a morphological feature of a particle obtained by shining light onto the particle, and a captured image obtained by imaging the particle, are acquired; a first trained model for outputting a particle image upon input of waveform data is generated by means of learning that employs first training data including the first waveform data and the captured image; category information indicating a category into which a particle is classified in accordance with the morphological feature is acquired in association with the particle image output by the first trained model when second waveform data are input into the first trained model; and data including the second waveform data and the category information are used as second training data for training a second trained model for outputting the category information upon input of the waveform data.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Cell sorter for use in the manufacture of pharmaceuticals;
machines and apparatus for manufacturing pharmaceuticals;
agitators; sifting installations; filtering machines;
separating machines for chemical processing; industrial
machine presses; crushing machines for industrial purposes;
extracting machines for chemical processing; kneading
machines; mixing machines; crushing machines; centrifuges
[machines]; sorting machines for chemical processing. Cell analyzer for laboratory use; blood analyzer for
laboratory use; flow cytometer for laboratory use; cell
separator for laboratory use; cell sorter for laboratory
use; bioreactors for cell culture; laboratory apparatus and
instruments; photographic, cinematographic and optical
apparatus and instruments; downloadable image files;
electronic publications [downloadable] provided from
databases or the Internet; cell analyzer for use in the
manufacture of pharmaceuticals; flow cytometer for use in
the manufacture of pharmaceuticals. Diagnostic apparatus for medical purposes; apparatus for
clinical diagnosis; cell analyzer for medical purposes;
blood analyzer for medical purposes; blood testing
apparatus; diagnostic imaging apparatus for medical
purposes; flow cytometer for medical purposes; cell
separator for medical purposes; cell sorter for medical
purposes; medical apparatus and instruments; massage
apparatus; pacifier clips; feeding cups for medical
purposes; thread for medical purposes; slings for medical
purposes; surgical catgut; apparatus, devices and articles
for nursing infants; suture materials; ear plugs for medical
purposes; ear plugs for sleeping; ear plugs for protection
against noise; protective gloves for medical purposes. Cell separation laboratory services; cell detection
laboratory services; cell analysis laboratory services;
research services in the field of proteins, antibodies,
microorganisms and cells; scientific services relating to
the isolation and cultivation of human tissues and cells;
research and development services in the field of cytology;
stem cell research; scientific research for medical purposes
in the field of cancerous diseases; development of
pharmaceutical preparations and medicines; medical research;
design and development of medical technology; testing,
inspection and research services in the fields of
pharmaceuticals, cosmetics and foodstuffs; scientific
research and development; scientific research, testing and
analysis services; industrial research, testing and analysis
services; product quality testing services; design and
development of diagnostic apparatus; product design and
development services; design services; computer programming
in the medical field; creation, design, development, and
maintenance of websites; testing and research services
relating to machines, apparatus and instruments; rental of
measuring apparatus; rental of laboratory apparatus and
instruments.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Cell sorter for use in the manufacture of pharmaceuticals;
machines and apparatus for manufacturing pharmaceuticals;
agitators; sifting installations; filtering machines;
separating machines for chemical processing; industrial
machine presses; crushing machines for industrial purposes;
extracting machines for chemical processing; kneading
machines; mixing machines; crushing machines; centrifuges
[machines]; sorting machines for chemical processing. Cell analyzer for laboratory use; blood analyzer for
laboratory use; flow cytometer for laboratory use; cell
separator for laboratory use; cell sorter for laboratory
use; bioreactors for cell culture; laboratory apparatus and
instruments; photographic, cinematographic and optical
apparatus and instruments; downloadable image files;
electronic publications [downloadable] provided from
databases or the Internet; cell analyzer for use in the
manufacture of pharmaceuticals; flow cytometer for use in
the manufacture of pharmaceuticals. Diagnostic apparatus for medical purposes; apparatus for
clinical diagnosis; cell analyzer for medical purposes;
blood analyzer for medical purposes; blood testing
apparatus; diagnostic imaging apparatus for medical
purposes; flow cytometer for medical purposes; cell
separator for medical purposes; cell sorter for medical
purposes; medical apparatus and instruments; massage
apparatus; pacifier clips; feeding cups for medical
purposes; thread for medical purposes; slings for medical
purposes; surgical catgut; apparatus, devices and articles
for nursing infants; suture materials; ear plugs for medical
purposes; ear plugs for sleeping; ear plugs for protection
against noise; protective gloves for medical purposes. Cell separation laboratory services; cell detection
laboratory services; cell analysis laboratory services;
research services in the field of proteins, antibodies,
microorganisms and cells; scientific services relating to
the isolation and cultivation of human tissues and cells;
research and development services in the field of cytology;
stem cell research; scientific research for medical purposes
in the field of cancerous diseases; development of
pharmaceutical preparations and medicines; medical research;
design and development of medical technology; testing,
inspection and research services in the fields of
pharmaceuticals, cosmetics and foodstuffs; scientific
research and development; scientific research, testing and
analysis services; industrial research, testing and analysis
services; product quality testing services; design and
development of diagnostic apparatus; product design and
development services; design services; computer programming
in the medical field; creation, design, development, and
maintenance of websites; testing and research services
relating to machines, apparatus and instruments; rental of
measuring apparatus; rental of laboratory apparatus and
instruments.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Cell sorter for use in the manufacture of pharmaceuticals;
machines and apparatus for manufacturing pharmaceuticals;
agitators; sifting installations; filtering machines;
separating machines for chemical processing; industrial
machine presses; crushing machines for industrial purposes;
extracting machines for chemical processing; kneading
machines; mixing machines; crushing machines; centrifuges
[machines]; sorting machines for chemical processing. Cell analyzer for laboratory use; blood analyzer for
laboratory use; flow cytometer for laboratory use; cell
separator for laboratory use; cell sorter for laboratory
use; cell analyzer, not for medical purposes; bioreactors
for cell culture; laboratory apparatus and instruments;
photographic, cinematographic and optical apparatus and
instruments; measuring and testing machines and instruments;
electrical communication machines and instruments; personal
digital assistants; computer hardware; computer software;
data storage apparatus; data processing equipment;
downloadable image files; electronic publications
[downloadable] provided from databases or the Internet; cell
analyzer for use in the manufacture of pharmaceuticals; flow
cytometer for use in the manufacture of pharmaceuticals. Diagnostic apparatus for medical purposes; apparatus for
clinical diagnosis; cell analyzer for medical purposes;
blood analyzer for medical purposes; blood testing
apparatus; diagnostic imaging apparatus for medical
purposes; flow cytometer for medical purposes; cell
separator for medical purposes; cell sorter for medical
purposes; medical apparatus and instruments; massage
apparatus; pacifier clips; feeding cups for medical
purposes; thread for medical purposes; slings for medical
purposes; surgical catgut; apparatus, devices and articles
for nursing infants; suture materials; ear plugs for medical
purposes; ear plugs for sleeping; ear plugs for protection
against noise; protective gloves for medical purposes. Cell separation laboratory services; cell detection
laboratory services; cell analysis laboratory services;
research services in the field of proteins, antibodies,
microorganisms and cells; scientific services relating to
the isolation and cultivation of human tissues and cells;
research and development services in the field of cytology;
stem cell research; scientific research for medical purposes
in the field of cancerous diseases; development of
pharmaceutical preparations and medicines; medical research;
design and development of medical technology; testing,
inspection and research services in the fields of
pharmaceuticals, cosmetics and foodstuffs; scientific
research and development; scientific research, testing and
analysis services; industrial research, testing and analysis
services; product quality testing services; design and
development of diagnostic apparatus; product design and
development services; design services; computer programming
in the medical field; creation, design, development, and
maintenance of websites; testing and research services
relating to machines, apparatus and instruments; rental of
measuring apparatus; rental of computer hardware and
computer software; rental of laboratory apparatus and
instruments.
48.
Flow cytometer performance evaluation method and standard particle suspension
A method of evaluating performance of a flow cytometer configured to use a combination of two or more types of calibration particles having different morphologies from each other, includes a first classification step of classifying the calibration particles from each other based on a first optical characteristic by the flow cytometer which is an evaluation target, a second classification step of classifying the calibration particles from each other based on a second optical characteristic which is classifiable at a spatial resolution lower than a spatial resolution at which the first optical characteristic is classified, and the evaluation step of evaluating one or both of particle classification performance and a resolution of the flow cytometer based on a first classification result assessed in the first classification step and a second classification result assessed in the second classification step.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Cell sorter for use in the manufacture of pharmaceuticals, namely, machines for sorting cells and removing non-conforming materials; machines and apparatus for manufacturing pharmaceuticals, namely, machine used for purification process and screening process in the pharmaceuticals industry and pharmaceutical production machine for producing pharmaceuticals Cell analyzer for laboratory use, namely, flow cytometers for cell analysis; blood analyzer for research laboratory use; flow cytometer for laboratory use; cell analyzer with cell sorting mechanism for laboratory use, namely, cytometers for cell separating for laboratory use; cell analyzer with cell sorting mechanism for laboratory use, namely, cytometers for cell sorting for laboratory use; cell analyzer for use in the manufacture of pharmaceuticals, namely, research laboratory cytometer for analyzing and measuring cells; flow cytometer for use in the manufacture of pharmaceuticals, namely, flow cytometer for analyzing, measuring and sorting cells; bioreactor for cell culturing; downloadable image files containing morphological information of cells; electronic downloadable publications in the nature of books in the field of cells provided from databases or the Internet; cell analyzer for use in the manufacture of pharmaceuticals, namely, cytometers; flow cytometers for use in the manufacture of pharmaceuticals Diagnostic apparatus for medical purposes, namely, apparatus for medical diagnostic testing in the fields of cancer, cytology and cell-based testing; diagnostic apparatus for clinical diagnosis, namely, optical diagnostic apparatus for diagnosing clinical or health conditions of test subjects; cell analyzer for medical purposes, namely, flow cytometers providing cell and particle analysis for medical diagnostic use; ultrasonic medical diagnostic apparatus; ultrasonic therapy apparatus; body composition analyzers for medical purposes; blood analyzer for medical purposes; blood testing apparatus; apparatus for taking blood; diagnostic imaging apparatus for medical purposes; flow cytometer for providing cell and particle detection for medical use; cell separator for medical purposes, namely, flow cytometers for separating cells for medical uses; cell sorter for medical purposes, namely, flow cytometers for sorting cells for medical uses; medical apparatus and instruments, namely, optical diagnostic apparatus to check clinical or health conditions of test subjects; massage apparatus; pacifier clips; feeding cups for medical purposes; thread for medical purposes; slings for medical purposes; surgical catgut; apparatus, devices and articles for nursing infants, namely, breast pumps; suture materials; ear plugs for medical purposes; ear plugs for sleeping; ear plugs for protection against noise; protective gloves for medical purposes Cell separation laboratory services for scientific research purposes; cell detection laboratory services for scientific research purposes; cell analysis laboratory services for scientific research purposes; scientific research services in the field of proteins, antibodies, microorganisms and cells; scientific services relating to the isolation and cultivation of human tissues and cells, namely, scientific research services; research and development services in the field of cytology; stem cell research services; scientific research for medical purposes in the field of cancerous diseases; development of pharmaceutical preparations and medicines; medical research; scientific research and development; product quality testing services; design and development of diagnostic apparatus; computer programming in the medical field; rental of laboratory apparatus and instruments
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Cell sorter for use in the manufacture of pharmaceuticals, namely, machines for sorting cells and removing non-conforming materials; machines and apparatus for manufacturing pharmaceuticals, namely, machine used for purification process and screening process in the pharmaceuticals industry and pharmaceutical production machine for producing pharmaceuticals Cell analyzer for laboratory use, namely, flow cytometers for cell analysis; blood analyzer for research laboratory use; flow cytometer for laboratory use; cell analyzer with cell sorting mechanism for laboratory use, namely, cytometers for cell separating for laboratory use; cell analyzer with cell sorting mechanism for laboratory use, namely, cytometers for cell sorting for laboratory use; cell analyzer for use in the manufacture of pharmaceuticals, namely, research laboratory cytometer for analyzing and measuring cells; flow cytometer for use in the manufacture of pharmaceuticals, namely, flow cytometer for analyzing, measuring and sorting cells; bioreactor for cell culturing; downloadable image files containing morphological information of cells; electronic downloadable publications in the nature of books in the field of cells provided from databases or the Internet; cell analyzer for use in the manufacture of pharmaceuticals, namely, cytometers; flow cytometers for use in the manufacture of pharmaceuticals Diagnostic apparatus for medical purposes, namely, apparatus for medical diagnostic testing in the fields of cancer, cytology and cell-based testing; diagnostic apparatus for clinical diagnosis, namely, optical diagnostic apparatus for diagnosing clinical or health conditions of test subjects; cell analyzer for medical purposes, namely, flow cytometers providing cell and particle analysis for medical diagnostic use; ultrasonic medical diagnostic apparatus; ultrasonic therapy apparatus; body composition analyzers for medical purposes; blood analyzer for medical purposes; blood testing apparatus; apparatus for taking blood; diagnostic imaging apparatus for medical purposes; flow cytometer for providing cell and particle detection for medical use; cell separator for medical purposes, namely, flow cytometers for separating cells for medical uses; cell sorter for medical purposes, namely, flow cytometers for sorting cells for medical uses; medical apparatus and instruments, namely, optical diagnostic apparatus to check clinical or health conditions of test subjects; massage apparatus; pacifier clips; feeding cups for medical purposes; thread for medical purposes; slings for medical purposes; surgical catgut; apparatus, devices and articles for nursing infants, namely, breast pumps; suture materials; ear plugs for medical purposes; ear plugs for sleeping; ear plugs for protection against noise; protective gloves for medical purposes Cell separation laboratory services for scientific research purposes; cell detection laboratory services for scientific research purposes; cell analysis laboratory services for scientific research purposes; scientific research services in the field of proteins, antibodies, microorganisms and cells; scientific services relating to the isolation and cultivation of human tissues and cells, namely, scientific research services; research and development services in the field of cytology; stem cell research services; scientific research for medical purposes in the field of cancerous diseases; development of pharmaceutical preparations and medicines; medical research; scientific research and development; product quality testing services; design and development of diagnostic apparatus; computer programming in the medical field; rental of laboratory apparatus and instruments
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Cell sorter for use in the manufacture of pharmaceuticals, namely, machines for sorting cells and removing non-conforming materials; machines and apparatus for manufacturing pharmaceuticals, namely, machine used for purification process and screening process in the pharmaceuticals industry and pharmaceutical production machine for producing pharmaceuticals Cell analyzer for laboratory use, namely, flow cytometers for cell analysis; blood research analyzer for laboratory use; flow cytometer for laboratory use; cell analyzer with cell sorting mechanism for laboratory use, namely, cytometers for cell separating for laboratory use; cell analyzer with cell sorting mechanism for laboratory use, namely, cytometers for cell sorting for laboratory use; cell analyzer for use in the manufacture of pharmaceuticals, namely, research laboratory cytometer for analyzing and measuring cells; flow cytometer for use in the manufacture of pharmaceuticals, namely, flow cytometer for analyzing, measuring and sorting cells; bioreactor for cell culturing; smartphones; personal digital assistants; computer hardware; computer software for use with medical technology, namely, downloadable computer software for measuring and analyzing cells; electronic data storage apparatus in the nature of memory media for storing information; data processing equipment; downloadable image files containing morphological information of cells; electronic downloadable publications in the nature of books in the field of cells provided from databases or the Internet; cell analyzer for use in the manufacture of pharmaceuticals, namely, cytometers; flow cytometers for use in the manufacture of pharmaceuticals Diagnostic apparatus for medical purposes, namely, apparatus for medical diagnostic testing in the fields of cancer, cytology and cell-based testing; diagnostic apparatus for clinical diagnosis, namely, optical diagnostic apparatus for diagnosing clinical or health conditions of test subjects; cell analyzer for medical purposes, namely, flow cytometers providing cell and particle analysis for medical diagnostic use; ultrasonic medical diagnostic apparatus; ultrasonic therapy apparatus; body composition analyzers for medical purposes; blood analyzer for medical purposes; blood testing apparatus; apparatus for taking blood; diagnostic imaging apparatus for medical purposes; flow cytometer for providing cell and particle detection for medical use; cell separator for medical purposes, namely, flow cytometers for separating cells for medical uses; cell sorter for medical purposes, namely, flow cytometers for sorting cells for medical uses; pacifier clips; feeding cups for medical purposes; thread for medical purposes; slings for medical purposes; surgical catgut; apparatus, devices and articles for nursing infants, namely, breast pumps; suture materials; ear plugs for medical purposes; ear plugs for sleeping; ear plugs for protection against noise; protective gloves for medical purposes Cell separation laboratory services for scientific research purposes; cell detection laboratory services for scientific research purposes; cell analysis laboratory services for scientific research purposes; scientific research services in the field of proteins, antibodies, microorganisms and cells; scientific services relating to the isolation and cultivation of human tissues and cells, namely, scientific research services; research and development services in the field of cytology; stem cell research services; scientific research for medical purposes in the field of cancerous diseases; development of pharmaceutical preparations and medicines; medical research; scientific research and development; product quality testing services; design and development of diagnostic apparatus; computer programming in the medical field; rental of laboratory apparatus and instruments
Cell sorter for use in the manufacture of pharmaceuticals;
cell analyzer for use in the manufacture of pharmaceuticals;
flow cytometer for use in the manufacture of
pharmaceuticals; machines and apparatus for manufacturing
pharmaceuticals; agitators; sifting installations; filtering
machines; separating machines for chemical processing;
industrial machine presses; crushing machines for industrial
purposes; extracting machines for chemical processing;
kneading machines; mixing machines; crushing machines;
centrifuges [machines]; sorting machines for chemical
processing.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Cell sorter for use in the manufacture of pharmaceuticals;
cell analyzer for use in the manufacture of pharmaceuticals;
flow cytometer for use in the manufacture of
pharmaceuticals; machines and apparatus for manufacturing
pharmaceuticals; agitators; sifting installations; filtering
machines; separating machines for chemical processing;
industrial machine presses; crushing machines for industrial
purposes; extracting machines for chemical processing;
kneading machines; mixing machines; crushing machines;
centrifuges [machines]; sorting machines for chemical
processing. Cell analyzer for laboratory use; blood analyzer for
laboratory use; flow cytometer for laboratory use; cell
separator for laboratory use; cell sorter for laboratory
use; cell analyzer, not for medical purposes; bioreactors
for cell culture; laboratory apparatus and instruments;
photographic, cinematographic and optical apparatus and
instruments; measuring and testing machines and instruments;
electrical communication machines and instruments; personal
digital assistants; computer hardware; computer software;
data storage apparatus; data processing equipment;
downloadable image files; electronic publications
[downloadable] provided from databases or the Internet. Diagnostic apparatus for medical purposes; apparatus for
clinical diagnosis; cell analyzer for medical purposes;
blood analyzer for medical purposes; blood testing
apparatus; diagnostic imaging apparatus for medical
purposes; flow cytometer for medical purposes; cell
separator for medical purposes; cell sorter for medical
purposes; medical apparatus and instruments; massage
apparatus; pacifier clips; feeding cups for medical
purposes; thread for medical purposes; slings for medical
purposes; surgical catgut; apparatus, devices and articles
for nursing infants; suture materials; ear plugs for medical
purposes; ear plugs for sleeping; ear plugs for protection
against noise; protective gloves for medical purposes. Cell separation laboratory services; cell detection
laboratory services; cell analysis laboratory services;
research services in the field of proteins, antibodies,
microorganisms and cells; scientific services relating to
the isolation and cultivation of human tissues and cells;
research and development services in the field of cytology;
stem cell research; scientific research for medical purposes
in the field of cancerous diseases; development of
pharmaceutical preparations and medicines; medical research;
design and development of medical technology; testing,
inspection and research services in the fields of
pharmaceuticals, cosmetics and foodstuffs; scientific
research and development; scientific research, testing and
analysis services; industrial research, testing and analysis
services; product quality testing services; design and
development of diagnostic apparatus; product design and
development services; design services; computer programming
in the medical field; creation, design, development, and
maintenance of websites; testing and research services
relating to machines, apparatus and instruments; rental of
measuring apparatus; rental of computer hardware and
computer software; rental of laboratory apparatus and
instruments.
Cell sorter being machines for sorting cells for use in the manufacture of pharmaceuticals; cell analyzer being machines for analyzing cells for use in the manufacture of pharmaceuticals; flow cytometer for use in the manufacture of pharmaceuticals; machines and machine apparatus for manufacturing pharmaceuticals
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Cell sorter being machines for sorting cells for use in the manufacture of pharmaceuticals; cell analyzer being machines for analyzing cells for use in the manufacture of pharmaceuticals; flow cytometer for use in the manufacture of pharmaceuticals; machines and machine apparatus for manufacturing pharmaceuticals Cell analyzer for laboratory use; blood analyzer for laboratory use; flow cytometer for laboratory use; cell separator for laboratory use; cell sorter for laboratory use; cell analyzer, not for medical purposes; bioreactor for cell culturing; smartphones; personal digital assistants; computer hardware; computer software for use with medical technology for analyzing cells, downloadable or recorded; data storage apparatus, namely, blank electronic storage media; data processing equipment; downloadable image files containing morphological information of cells; downloadable electronic publications in the nature of reports in the field of cells provided from databases or the Internet Diagnostic apparatus for medical purposes for testing cells; apparatus for clinical diagnosis, namely, apparatus for diagnosing medical conditions of test subjects by detecting cancer cells in the blood or circulating tumor cells; cell analyzer for medical purposes; ultrasonic medical diagnostic apparatus; ultrasonic therapy apparatus; body composition analyzers for medical purposes; blood analyzer for medical purposes; blood testing apparatus; apparatus for taking blood; diagnostic imaging apparatus for medical purposes; flow cytometer for medical purposes; cell separator for medical purposes; cell sorter for medical purposes; medical apparatus and instruments, namely, diagnostic apparatus to check clinical or health conditions of test subjects suffering from or suspected of suffering from hematological disorder; massage apparatus; pacifier clips; feeding cups for medical purposes; thread for medical purposes; slings for medical purposes; surgical catgut; apparatus, devices and articles for nursing infants; suture materials; ear plugs for medical purposes; ear plugs for sleeping; ear plugs for protection against noise; protective gloves for medical purposes Cell separation laboratory services for scientific research purposes; cell detection laboratory services for scientific research purposes; cell analysis laboratory services for scientific research purposes; medical research services and scientific research services in the field of proteins, antibodies, microorganisms and cells; scientific services relating to the isolation and cultivation of human tissues and cells, namely, scientific research services; research and development services in the field of cytology; stem cell research services; scientific research for medical purposes in the field of cancerous diseases; development of pharmaceutical preparations and medicines; medical research; scientific research and development; product quality testing services; design and development of diagnostic apparatus; computer programming in the medical field; rental of computer hardware and computer software for analyzing cells; rental of computers; rental of laboratory apparatus and instruments
The present disclosure provides a method for identifying a nucleic acid, which may comprise incubating a cell that has been or is suspected of having been transfected or transduced with an exogenous ribonucleic acid (RNA) molecule or an exogenous deoxyribonucleic (DNA) molecule. Next, a morphological change of the cell may be identified. Next, contents of the cell may be processed to identify a nucleic acid sequence or a peptide, polypeptide, or protein or a sequence of the peptide, polypeptide, or protein. Next, the nucleic acid sequence or the peptide, polypeptide, or protein or the sequence of the peptide, polypeptide, or protein may be analyzed to determine an exogenous sequence of the exogenous RNA molecule or the exogenous DNA molecule. Next, the exogenous sequence of the exogenous RNA molecule or the exogenous DNA molecule may be identified as effecting the morphological change of the cell. The exogenous RNA molecule or the exogenous DNA molecule may encode genes or peptides, polypeptides, or proteins that inhibit, activate, or modulate a biochemical pathway within the cell, thereby causing the morphological change of the cell.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Cell sorter for use in the manufacture of pharmaceuticals;
machines and apparatus for manufacturing pharmaceuticals;
agitators; sifting installations; filtering machines;
separating machines for chemical processing; industrial
machine presses; crushing machines for industrial purposes;
extracting machines for chemical processing; kneading
machines; mixing machines; crushing machines; centrifuges
[machines]; sorting machines for chemical processing. Cell analyzer for laboratory use; blood analyzer for
laboratory use; flow cytometer for laboratory use; cell
separator for laboratory use; cell sorter for laboratory
use; cell analyzer, not for medical purposes; bioreactors
for cell culture; laboratory apparatus and instruments;
photographic, cinematographic and optical apparatus and
instruments; measuring and testing machines and instruments;
electrical communication machines and instruments; personal
digital assistants; computer hardware; computer software;
data storage apparatus; data processing equipment;
downloadable image files; electronic publications
[downloadable] provided from databases or the Internet; cell
analyzer for use in the manufacture of pharmaceuticals; flow
cytometer for use in the manufacture of pharmaceuticals. Diagnostic apparatus for medical purposes; apparatus for
clinical diagnosis; cell analyzer for medical purposes;
blood analyzer for medical purposes; blood testing
apparatus; diagnostic imaging apparatus for medical
purposes; flow cytometer for medical purposes; cell
separator for medical purposes; cell sorter for medical
purposes; medical apparatus and instruments; massage
apparatus; pacifier clips; feeding cups for medical
purposes; thread for medical purposes; slings for medical
purposes; surgical catgut; apparatus, devices and articles
for nursing infants; suture materials; ear plugs for medical
purposes; ear plugs for sleeping; ear plugs for protection
against noise; protective gloves for medical purposes. Cell separation laboratory services; cell detection
laboratory services; cell analysis laboratory services;
research services in the field of proteins, antibodies,
microorganisms and cells; scientific services relating to
the isolation and cultivation of human tissues and cells;
research and development services in the field of cytology;
stem cell research; scientific research for medical purposes
in the field of cancerous diseases; development of
pharmaceutical preparations and medicines; medical research;
design and development of medical technology; testing,
inspection and research services in the fields of
pharmaceuticals, cosmetics and foodstuffs; scientific
research and development; scientific research, testing and
analysis services; industrial research, testing and analysis
services; product quality testing services; design and
development of diagnostic apparatus; product design and
development services; design services; computer programming
in the medical field; creation, design, development, and
maintenance of websites; testing and research services
relating to machines, apparatus and instruments; rental of
measuring apparatus; rental of computer hardware and
computer software; rental of laboratory apparatus and
instruments.
Diagnostic apparatus for medical purposes used to check health or clinical conditions of test subjects; apparatus for clinical laboratory tests of test subjects; ultrasonic medical diagnostic apparatus; ultrasonic therapy apparatus; body composition analyzers for medical purposes; diagnostic imaging apparatus for medical purposes; flow cytometer used to check health or clinical conditions of test subjects, namely, cell analyzer for medical purposes; flow cytometer for medical diagnostic purposes; flow cytometer for medical diagnostic purposes, namely, cell separator for medical purposes; flow cytometer for medical diagnostic purposes, namely, cell sorter for medical purposes; blood analyzer for medical purposes; blood testing apparatus; apparatus for taking blood; medical apparatus and instruments, namely, diagnostic apparatus to check clinical or health conditions of test subjects; pacifier clips; feeding cups for medical purposes; thread for medical purposes; slings for medical purposes; surgical catgut; suture materials
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Cell sorter for use in the manufacture of pharmaceuticals, namely, machines for sorting cells and removing non-conforming materials Cell analyzer for laboratory use, namely, flow cytometers for cell analysis; blood analyzer for research laboratory use; flow cytometer for laboratory use; flow cytometer for laboratory use, namely, cell separator for laboratory use; flow cytometer for laboratory use, namely, cell sorter for laboratory use; cell analyzer, not for medical purposes, namely, flow cytometers for cell analysis, not for medical purposes; bioreactor for cell culturing; downloadable image files containing morphological information of cells; cell analyzer for use in the manufacture of pharmaceuticals, namely, machines for analyzing or measuring cells; flow cytometer for use in the manufacture of pharmaceuticals, namely, machines for analyzing, measuring or sorting cells Medical or scientific laboratory services in the field of cell separation; medical or scientific laboratory services in the field of cell detection; medical or scientific laboratory services in the field of cell analysis; Medical or scientific research services in the field of proteins, antibodies, microorganisms and cells; scientific services relating to the isolation and cultivation of human tissues and cells, namely, scientific research services; research and development services in the field of cytology; stem cell research services; scientific research for medical purposes in the field of cancerous diseases; development of pharmaceutical preparations and medicines; medical research; scientific research and development; product quality testing services; design and development of diagnostic apparatus; computer programming in the medical field; rental of laboratory apparatus and instruments
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Cell analyzer, not for medical purposes; bioreactors for
cell culture; flow cytometer for laboratory use; cell
separator for laboratory use; cell sorter for laboratory
use; laboratory apparatus and instruments; photographic,
cinematographic and optical apparatus and instruments;
measuring and testing machines and instruments; electrical
communication machines and instruments; smartphones;
personal digital assistants; computer hardware; computer
software; data storage apparatus; data processing equipment;
downloadable image files; electronic publications
[downloadable] provided from databases or the Internet. Cell analyzer for medical purposes; flow cytometer for
medical purposes; cell separator for medical purposes; cell
sorter for medical purposes; diagnostic imaging apparatus
for medical purposes; medical apparatus; massage apparatus;
pacifier clips; feeding cups for medical purposes; thread
for medical purposes; slings for medical purposes; surgical
catgut; apparatus, devices and articles for nursing infants;
suture materials; ear plugs for medical purposes; ear plugs
for sleeping; ear plugs for protection against noise;
protective gloves for medical purposes. Research services in the field of proteins, antibodies,
microorganisms and cells; scientific services relating to
the isolation and cultivation of human tissues and cells;
research and development services in the field of cytology;
stem cell research; scientific research for medical purposes
in the field of cancerous diseases; development of
pharmaceutical preparations and medicines; medical research;
design and development of medical technology; testing,
inspection and research services in the fields of
pharmaceuticals, cosmetics and foodstuffs; scientific
research and development; scientific research, testing and
analysis services; industrial research, testing and analysis
services; product quality testing services; design and
development of diagnostic apparatus; product design and
development services; design services; computer programming
in the medical field; creation, design, development, and
maintenance of websites; testing and research services
relating to machines, apparatus and instruments; rental of
measuring apparatus; rental of computer hardware and
computer software; rental of laboratory apparatus and
instruments.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
42 - Scientific, technological and industrial services, research and design
Goods & Services
Cell analyzer, not for medical purposes; [bioreactor for cell culturing;] flow cytometer for laboratory use; cell separator for laboratory use; cell sorter for laboratory use [Cell analyzer for medical purposes; flow cytometer for medical purposes; cell separator for medical purposes; cell sorter for medical purposes] Research services in the field of proteins, antibodies, microorganisms and cells; scientific services relating to the isolation and cultivation of human tissues and cells, namely, scientific research services; research and development services in the field of cytology; stem cell research services; [scientific research for medical purposes in the field of cancerous diseases; development of pharmaceutical preparations and medicines; medical research; scientific research and development; product quality testing services; computer programming in the medical field;] rental of laboratory apparatus and instruments
