Abstract

Provided is a scintillator unit (11) comprising: a holding member having two element-row-accommodating frame parts (44), and frame connection parts (41, 42) for connecting the two element-row-accommodating frame parts so that an element array arrangement space is formed therebetween, the frame parts and the frame connection parts being configured from a material that blocks scintillating light; a plurality of first scintillator elements (3) that are accommodated in each of the two element-row-accommodating frame parts in a state of being arrayed one-dimensionally; and a plurality of second scintillator elements (3) that are arranged in the element array arrangement space in a state of being arrayed two-dimensionally. Also provided is a radiation detector (1) comprising: a scintillator unit (11); and a photodetector (7) having a plurality of detection elements (71) for detecting the intensity at each incidence position of light emitted from the scintillator element.

IPC Classes  ?

• G01T 1/20 - Measuring radiation intensity with scintillation detectors
• G01T 1/161 - Applications in the field of nuclear medicine, e.g. in vivo counting
• G21K 4/00 - Conversion screens for the conversion of the spatial distribution of particles or ionising radiation into visible images, e.g. fluoroscopic screens

Abstract

Provided are a particle beam irradiating device capable of reducing a distance between an irradiation field forming device of the particle beam irradiating device and a patient, as well as an energy modulating device used for the particle beam irradiating device. The energy modulating device, i.e. a ripple filter 7, used for the particle beam irradiating device 10 that transports, by a beam transport line 2, a charged particle beam extracted from an accelerator 1 and delivers the charged particle beam by a scanning method using scanning magnets 4 and 5. The energy modulating device, i.e. the ripple filter 7, includes a filter member 70 having a plurality of openings 72 which penetrate the filter member 70 in a thickness direction and through which at least a part of the charged particle beam passes, in which the filter member 70 is one of two or more filter members overlapped in the thickness direction.

IPC Classes  ?

• G21K 1/10 - Scattering devicesAbsorbing devices
• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy
• G21K 1/093 - Deviation, concentration, or focusing of the beam by electric or magnetic means by magnetic means

Abstract

The present disclosure relates to compounds of formula (I) and pharmaceutically acceptable salts or solvates thereof: in formula (I), X1and X2each independently are a radioactive halogen nuclide, hydrogen, or deuterium, R1, R2, and R3each independently are hydrogen or deuterium, at least one of X1, X2, , R1, R2, and R3is deuterium, at least one of X1and X2 is a radioactive halogen nuclide, and Y is a methyl group and an isopropyl group.

IPC Classes  ?

• C07D 417/04 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings directly linked by a ring-member-to-ring- member bond
• A61K 31/506 - PyrimidinesHydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
• A61K 51/04 - Organic compounds
• A61P 35/00 - Antineoplastic agents

Abstract

m 0 M 0 M M and the uncertainty map. Thereby, an image processing device is implemented which can suppress a deterioration in the image quality due to excessive smoothing occurring in the noise reduction processing using DIP technology.

IPC Classes  ?

• G06T 5/60 - Image enhancement or restoration using machine learning, e.g. neural networks
• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• A61B 6/03 - Computed tomography [CT]
• G01T 1/161 - Applications in the field of nuclear medicine, e.g. in vivo counting
• G06T 1/00 - General purpose image data processing
• G06T 5/70 - DenoisingSmoothing

Abstract

According to an embodiment, a medical image processing device includes an image acquirer, a trajectory generator, and a selector. The image acquirer acquires a plurality of fluoroscopic images by imaging a patient. The trajectory generator recognizes a position of a part of interest shown in each of the plurality of fluoroscopic images and generates a trajectory of a state in which the part of interest has moved based on the recognized position of the part of interest. The selector selects a tracking method for tracking the part of interest based on the trajectory of the part of interest.

IPC Classes  ?

• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• A61B 6/04 - Positioning of patientsTiltable beds or the like
• A61B 6/46 - Arrangements for interfacing with the operator or the patient

Abstract

Provided is a compound that has high binding selectivity with respect to α-synuclein aggregates. Provided is a compound that has high binding selectivity with respect to α-synuclein aggregates. Provided is a compound represented by the following formula (I), (II), or (III), a pharmaceutically acceptable salt thereof, or a solvate thereof. Provided is a compound that has high binding selectivity with respect to α-synuclein aggregates. Provided is a compound represented by the following formula (I), (II), or (III), a pharmaceutically acceptable salt thereof, or a solvate thereof.

IPC Classes  ?

• A61K 51/04 - Organic compounds
• A61K 49/00 - Preparations for testing in vivo
• C07D 417/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• C07D 417/14 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing three or more hetero rings
• C07D 513/04 - Ortho-condensed systems

Abstract

The present invention provides technology for dissolving more lithium without performing a calcination step at a high temperature. A method (M10) for producing a lithium solution comprises: a pulverization step (S11) for pulverizing lithium ore that contains α-spodumene by causing a medium to collide with the lithium ore; and a dissolution step (S12) for dissolving, in an acid solution, powder of the lithium ore which is obtained in the pulverization step (S11).

IPC Classes  ?

• C22B 3/08 - Sulfuric acid
• C22B 23/00 - Obtaining nickel or cobalt

Abstract

Provided is a metal ion recovery device and a metal ion recovery method with which it is possible to use an ion-permeable membrane stably for a long period of time. A lithium recovery device 1 comprises: a treatment tank 2 that accommodates a stock solution 100, which is an aqueous solution and contains lithium, and a recovery liquid 200, which is an aqueous solution; an ion-permeable membrane 3 that is disposed so as to partition the stock solution 100 and the recovery liquid 200 in the treatment tank 2, and that is mainly composed of an ion conductor of lithium; a positive electrode 4 that is provided on one main surface of the ion-permeable membrane 3; a negative electrode 5 that is provided on another main surface of the ion-permeable membrane 3; and a current collector 6 that is provided between the ion-permeable membrane 3 and the positive electrode 4, or between the ion-permeable membrane 3 and the negative electrode 5. The contact area between the ion-permeable membrane 3 and the current collector 6 is 5% or less of the total area of the main surfaces of the ion-permeable membrane 3.

IPC Classes  ?

• C02F 1/469 - Treatment of water, waste water, or sewage by electrochemical methods by electrochemical separation, e.g. by electro-osmosis, electrodialysis, electrophoresis
• B01D 61/44 - Ion-selective electrodialysis
• C22B 26/12 - Obtaining lithium

Abstract

The present invention suppresses deterioration of time resolution due to a connection layer connecting a scintillator array and a light receiving element array. A radiation detection device (10) comprises: a scintillator array (11) having a plurality of scintillators (11(i)); a light receiving element array (12) having a plurality of light receiving elements (12(j)) facing the scintillator array, and a translucent connection layer (13) formed on the plurality of light receiving elements and connected to the scintillator array; and a light reflecting member (14) placed in the connection layer along a boundary between the plurality of light receiving elements. The thickness of the light reflecting member is equal to or greater than an interval between the end surfaces of the plurality of scintillator arrays and the light receiving surfaces of the plurality of light receiving elements.

IPC Classes  ?

• G01T 1/20 - Measuring radiation intensity with scintillation detectors

Abstract

The problem addressed by the present invention is to provide an anion conductive electrolyte membrane and a binder for anion conduction, which are excellent in terms of alkali resistance at high temperatures and gas barrier properties. The second problem addressed by the present invention is to provide a resin composition which promotes graft polymerization of a base material that is composed of an aromatic hydrocarbon-based polymer, and which has a high graft ratio with respect to the base material. In order to solve the problem, the present invention provides a resin composition which uses an aromatic hydrocarbon-based polymer as a base material and has a graft polymer chain on the base material, and which is characterized in that the graft polymer chain has a cationic functional group. In order to solve the second problem, the present invention provides a method for producing a resin composition which uses an aromatic hydrocarbon-based polymer as a base material, the method being characterized by including a pretreatment step in which the base material is immersed in a solvent.

IPC Classes  ?

• C08J 7/16 - Chemical modification with polymerisable compounds
• C08F 283/06 - Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass on to polyethers, polyoxymethylenes or polyacetals
• C08J 5/22 - Films, membranes or diaphragms
• C25B 1/04 - Hydrogen or oxygen by electrolysis of water
• C25B 9/00 - Cells or assemblies of cellsConstructional parts of cellsAssemblies of constructional parts, e.g. electrode-diaphragm assembliesProcess-related cell features
• C25B 9/23 - Cells comprising dimensionally-stable non-movable electrodesAssemblies of constructional parts thereof with diaphragms comprising ion-exchange membranes in or on which electrode material is embedded
• C25B 13/08 - DiaphragmsSpacing elements characterised by the material based on organic materials
• H01B 1/06 - Conductors or conductive bodies characterised by the conductive materialsSelection of materials as conductors mainly consisting of other non-metallic substances
• H01M 4/86 - Inert electrodes with catalytic activity, e.g. for fuel cells
• H01M 8/10 - Fuel cells with solid electrolytes
• H01M 8/1018 - Polymeric electrolyte materials
• H01M 8/1025 - Polymeric electrolyte materials characterised by the chemical structure of the main chain of the ion-conducting polymer having only carbon and oxygen, e.g. polyethers, sulfonated polyetheretherketones [S-PEEK], sulfonated polysaccharides, sulfonated celluloses or sulfonated polyesters
• H01M 8/1072 - Polymeric electrolyte materials characterised by the manufacturing processes by chemical reactions, e.g. insitu polymerisation or insitu crosslinking
• H01M 12/06 - Hybrid cellsManufacture thereof composed of a half-cell of the fuel-cell type and of a half-cell of the primary-cell type with one metallic and one gaseous electrode
• H01M 12/08 - Hybrid cellsManufacture thereof composed of a half-cell of a fuel-cell type and a half-cell of the secondary-cell type

Abstract

The relationship between coordinates associated with the distribution of radiation rays emitted from the inside of a physical object and coordinates associated with the outer shape of this physical object is easily derived. Based on first 3D data (Da) in which the distribution of radiation rays emitted from the inside of a physical object (subject P) is represented in first coordinates (Ca), second 3D data (Db) in which the inside and the outer shape of the physical object are represented in second coordinates (Cb), and third 3D data (Dc) in which at least a part of the outer shape of the physical object is represented in third coordinates (Cc), a relationship (R) between the first coordinates and the third coordinates is derived.

IPC Classes  ?

• G06T 7/33 - Determination of transform parameters for the alignment of images, i.e. image registration using feature-based methods
• G06T 7/246 - Analysis of motion using feature-based methods, e.g. the tracking of corners or segments

Abstract

In order to realize a production method, for forming a group IV-vacancy center, in which efficiency of the formation of the group IV-vacancy center is improved, a generation method for the group IV-vacancy (V) center according to the present invention includes: a preparation step (S11) for preparing a diamond that includes a group IV element and a vacancy; and a rapid thermal annealing step (S12) for forming the group IV-vacancy center in the diamond by performing rapid thermal annealing of the diamond at a target temperature of 800°C or higher.

IPC Classes  ?

• C30B 29/04 - Diamond

Abstract

The objective of the present invention is to provide a signal processing device capable of calculating the detection time at which a radiation detection device detects radiation by taking into account the characteristics of the radiation detection device. This signal processing device (3) for processing an output signal from a radiation detection device (2) including a plurality of scintillators, which emit fluorescence according to incident radiation, and a plurality of light-receiving elements, which detect fluorescence, comprises a processor that executes: an identification process for identifying, from the output signal, the detection time at which the light-receiving elements detected the fluorescence emitted by the scintillators and the imparted energy imparted to the light-receiving elements; and a calculation process for calculating, as the detection time at which the radiation detection device detected the fluorescence, a weighted average of the detection times detected by the light-receiving elements, wherein the weights are the n-th power (n is a real number greater than 1) of the energy corresponding to each of the light-receiving elements.

IPC Classes  ?

• G01T 1/20 - Measuring radiation intensity with scintillation detectors
• G01T 1/161 - Applications in the field of nuclear medicine, e.g. in vivo counting

Abstract

A medical image processing device includes a first image acquirer, a second image acquirer, an area acquirer, an image similarity calculator, a cost calculator, and a registrator. The first image acquirer acquires a first image which is captured by imaging an internal body of a patient. The second image acquirer acquires a second image which is captured by imaging the internal body of the patient at a time point different from that of the first image. The area acquirer acquires two or more areas corresponding to the first image or the second image. The image similarity calculator calculates a similarity between the first image and the second image. The cost calculator calculates a cost based on a positional relationship between the areas. The registrator calculates a relative position of the first image with respect to the second image to increase the similarity and to decrease the cost.

IPC Classes  ?

• G16H 30/40 - ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing

Abstract

Provided is an image analysis device (30) for analyzing a light field image of a sample including at least one quantum sensor and imaged by a light field optical system in a state in which the sample is irradiated with excitation light and microwaves, the image analysis device including: an image reconstruction unit (32) for reconstructing images, refocused to each of depth positions, from the light field image of the sample; a three-dimensional reconstruction unit (33) for reconstructing a volumetric image of the sample by stacking the reconstructed images at each of the depth positions; a quantum sensor position identification unit (34) for determining the three-dimensional spatial coordinates of each of the quantum sensors in the volumetric image of the sample; a fluorescence intensity identification unit (35) for determining the fluorescence intensity of each of the quantum sensors from a fluorescence beam originating from the same quantum sensor captured in the light field image of the sample; and a physical quantity calculation unit (36) for calculating a physical quantity at the three-dimensional spatial coordinates of each of the quantum sensors from the fluorescence intensity of each of the quantum sensors.

IPC Classes  ?

• G01N 24/10 - Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using electron paramagnetic resonance
• G01N 21/64 - FluorescencePhosphorescence

Abstract

In the present invention, an image analysis device (30) is configured so that, in a state in which a sample that includes a quantum sensor is irradiated with excitation light of a wavelength at which fluorescence is excited in the quantum sensor and microwaves of a frequency at which optical detection magnetic resonance occurs in the quantum sensor, the image analysis device analyzes a multi-viewpoint image of the sample captured by a compound-eye optical system. The image analysis device comprises: a fluorescence intensity identification unit (32) that determines the fluorescence intensity of the quantum sensor on the basis of fluorescence rays from the quantum sensor evident in a plurality of element images in the multi-viewpoint image of the sample; and a physical quantity calculation unit (33) that calculates a physical quantity indicated by the quantum sensor on the basis of the fluorescence intensity of the quantum sensor.

IPC Classes  ?

• G01N 24/10 - Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using electron paramagnetic resonance
• G01N 21/64 - FluorescencePhosphorescence

Abstract

The present disclosure pertains to a method for estimating the accumulation amount of TDP-43 in the brain. An epitope of one antibody among a capture antibody and a detection antibody used in said method includes a peptide up to the 203rd to 209th amino acids of the amino acid sequence represented by SEQ ID NO: 1. An epitope of the other antibody is: an epitope included in a peptide composed of the 261st to 414th amino acids of the amino acid sequence represented by SEQ ID NO: 1; or an epitope including a peptide which is composed of the 404th to 410th amino acids and in which the 409th and 410th serines are phosphorylated.

IPC Classes  ?

• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters

Abstract

The present invention addresses the problem that many conventional nano-sized contrast agents are aggregates of a plurality of constituent molecules and, under diluted conditions resulting from prolonged blood circulation, dissociate by reaching a critical micelle concentration (CMC) or critical aggregate concentration (CAC) or lower, such that it is difficult to control in vivo kinetics thereof up to the discharge phase. The present invention provides a polymeric micelle comprising a single polymer chain of a self-aggregating type, said single polymer chain containing one or more gadolinium complexes and having a particle size of not more than 10 nm in water.

IPC Classes  ?

• A61K 9/10 - DispersionsEmulsions
• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• A61K 51/12 - Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes
• A61P 35/00 - Antineoplastic agents
• A61K 103/34 - Gadolinium

Abstract

In a technique to vibrate a target using a laser induced plasma shock wave, in order to enhance efficiency of vibrating a target as compared with a conventional technique, a vibration device includes a condenser lens, and a shock tube in which a first end of an internal space is sealed by the condenser lens and a second end of the internal space is opened. The condenser lens condenses supplied laser light in the internal space of the shock tube. The shock tube outputs the laser induced plasma shock wave from the second end.

IPC Classes  ?

• G01N 29/24 - Probes
• G01N 29/04 - Analysing solids
• G02B 19/00 - Condensers

Abstract

A large electron tube includes: a tubular collector; and a magnetic body disposed outside the collector and having no axial symmetry with respect to a center axis of the collector. This makes it possible to inhibit parasitic oscillation that occurs inside the collector.

IPC Classes  ?

• H01J 23/11 - Means for reducing noise
• H01J 23/027 - Collectors
• H01J 23/075 - Magnetron injection guns
• H01J 23/10 - Magnet systems for directing or deflecting the discharge along a desired path, e.g. a spiral path
• H01J 25/02 - Tubes with electron stream modulated in velocity or density in a modulator zone and thereafter giving-up energy in an inducing zone, the zones being associated with one or more resonators
• H01J 25/10 - Klystrons, i.e. tubes having two or more resonators, without reflection of the electron stream, and in which the stream is modulated mainly by velocity in the zone of the input resonator

Abstract

An image configuration device 1 acquires measurement data captured by a PET device 2 according to a time series, distinguishes body movement data relating to body movement of a subject obtained from the PET device 2 according to the time series for each prescribed unit time, acquires the body movement data as a unit time measurement value, sets a frame division point when the amount of variation in the unit time measurement value exceeds a prescribed threshold value, generates correction data in which measurement data is corrected in order to cancel out body movement of the subject in each frame unit divided at the division point, and reconstructs a medical image on the basis of the correction data for each frame. This makes it possible to obtain a highly accurate PET image without fixing a subject in PET inspection.

IPC Classes  ?

• G01T 1/161 - Applications in the field of nuclear medicine, e.g. in vivo counting

Abstract

A time-series signal prediction device according to an embodiment has a time-series signal acquisition unit, a block conversion unit, a feature vector acquisition unit, and a feature vector conversion unit. The time-series signal acquisition unit acquires a time-series signal relating to biological information of a patient. The block conversion unit divides the time-series signal into partial signals at predetermined intervals and converts the same into time-series block signals shorter than the time-series of the time-series signal. From the block signals, the feature vector acquisition unit outputs a feature vector representing a time-series signal for a time in the future from when the time-series signal was acquired. The feature vector conversion unit converts the feature vector into a prediction signal relating to biological information of the patient.

IPC Classes  ?

• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy

Abstract

A nematode-encapsulated capsule of the present disclosure includes: an encapsulation composition containing a nematode; and at least one layer made of membrane with which the encapsulation composition is encapsulated. The membrane contains, as a main component, a water-soluble polymer that gelatinizes by reacting with a cation.

IPC Classes  ?

• G01N 33/50 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing
• C12N 11/04 - Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms

Abstract

Provided is a transmission device capable of, by using a simple configuration, transmitting a substance to be administered, while maintaining the super-polarization performance of the substance. This transmission device 4 is provided between: a polarization device 3; and an imaging device 2 that uses nuclear magnetic resonance. The transmission device is used when a substance super-polarized by the polarization device 3 is transferred to a location where the substance is used. The transmission device 4 comprises: a transmission tube 41 that forms a transmission path through which the substance is transmitted; a magnet 42 that generates a magnetic field in the transmission path; and a yoke 43 that is disposed so as to constitute a magnetic circuit with the magnet 42 and that has a relative permeability of 100 or greater.

IPC Classes  ?

• A61B 5/055 - Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fieldsMeasuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• F16L 11/12 - Hoses, i.e. flexible pipes made of rubber or flexible plastics with arrangements for particular purposes, e.g. specially profiled, with protecting layer, heated, electrically conducting
• F17D 1/08 - Pipe-line systems for liquids or viscous products

Abstract

A medical image processing device according to an embodiment has a first image acquirer, a second image acquirer, a shifter, and a display controller. The first image acquirer acquires a first three-dimensional fluoroscopic image that is a three-dimensional fluoroscopic image of a patient captured in a patient treatment planning stage. The second image acquirer acquires a second three-dimensional fluoroscopic image that is a three-dimensional fluoroscopic image of the patient captured in a patient treatment stage. The shifter adds a predetermined amount to a photographing center position of the second three-dimensional fluoroscopic image to shift a display center position of the second three-dimensional fluoroscopic image. The display controller causes a display device to display a cross-sectional image of the second three-dimensional fluoroscopic image so that the display center position of the second three-dimensional fluoroscopic image is a center of a display region in a positioning stage of the patient treatment stage.

IPC Classes  ?

• G03B 42/02 - Obtaining records using waves other than optical wavesVisualisation of such records by using optical means using X-rays
• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy

Abstract

According to an embodiment, a medical image processing device includes a first image acquirer, a second image acquirer, a treatment error acquirer, a difference calculator, and a differential statistical quantity calculator. The first image acquirer acquires a first fluoroscopic image of a patient. The second image acquirer acquires a second fluoroscopic image photographed at a timing different from the first fluoroscopic image. The treatment error acquirer acquires a treatment error occurring when an alignment process is performed or a treatment error occurring in treatment. The difference calculator calculates a difference image between the second fluoroscopic image to which the virtual perturbation is applied at the position of the patient shown therein based on the treatment error and the first fluoroscopic image. The differential statistical quantity calculator calculates a statistical quantity of a difference between the first fluoroscopic image and the second fluoroscopic image based on the difference image.

IPC Classes  ?

• G06T 7/00 - Image analysis

Abstract

A medical image processing device according to an embodiment has a first image acquirer, a second image acquirer, a 3D-3D positioning executer, and a display controller. The first image acquirer acquires a first three-dimensional fluoroscopic image that is a three-dimensional fluoroscopic image of a patient. The second image acquirer acquires a second three-dimensional fluoroscopic image that is a three-dimensional fluoroscopic image of the patient. The 3D-3D positioning executer calculates a first shift amount between the first three-dimensional fluoroscopic image and the second three-dimensional fluoroscopic image. The display controller causes the display device to display a first DRR image generated from the second three-dimensional fluoroscopic image corrected based on the first shift amount, and a two-dimensional fluoroscopic image of the patient.

IPC Classes  ?

• G06T 7/00 - Image analysis
• A61B 5/00 - Measuring for diagnostic purposes Identification of persons
• G06F 3/14 - Digital output to display device
• G06T 15/00 - 3D [Three Dimensional] image rendering

Abstract

The present disclosure relates to a method for estimating the amount of tau protein accumulation in the brain. One of the capture antibody and the detection antibody used in the method is an antibody that recognizes the amino acid sequence of the intermediate part of a phosphorylated tau protein, while the other is an antibody that recognizes a phosphorylated epitope including a phosphorylated amino acid residue of the phosphorylated tau protein.

IPC Classes  ?

• G01N 33/53 - ImmunoassayBiospecific binding assayMaterials therefor
• C07K 16/18 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans
• C07K 16/28 - Immunoglobulins, e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
• C12N 15/13 - Immunoglobulins
• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals

Abstract

The present invention addresses the problem of providing a manipulator positioning device and positioning method with which it is possible, in relation to an operation of a manipulator, to perform intuitive positioning of the manipulator by inexpensively and easily detecting the relative positions of the manipulator and an object of operation. A manipulator positioning device and method for solving the above problem are characterized in being provided with a light source attached to a manipulator tip, a first target for receiving irradiation light emitted from the light source, and a second target for receiving the irradiation light emitted from the light source, the first target and the second target being at different distances from the light source.　The need for newly mounting a camera or performing image processing is thereby obviated, and it becomes possible to inexpensively and simply perform detection of the relative positions of the manipulator and the object of operation. In addition, intuitive positioning of the manipulator is enabled.

IPC Classes  ?

• G01S 3/782 - Systems for determining direction or deviation from predetermined direction
• B25J 19/02 - Sensing devices

Abstract

The present invention makes it possible to increase the amount of ions generated. An ion generator 1 according to the present invention comprises: a microwave waveguide 13 whereby ionization energy for ionizing the atoms of a gas is supplied into a plasma chamber 11 for generating an ion beam 1b from a gas introduced into a vacuum; an auxiliary electrode 19 arranged in the plasma chamber 11; an auxiliary voltage application unit 20 that applies a negative auxiliary voltage to the auxiliary electrode 19; and an auxiliary voltage control unit 36 for controlling the voltage value of the auxiliary voltage applied from the auxiliary voltage application unit 20 to the auxiliary electrode 19. The auxiliary voltage control unit 36 changes the voltage value of the auxiliary voltage over time as a two-level pulse wave of a first voltage value V1 and a second voltage value V2 having a lower voltage value than the first voltage value V1.

IPC Classes  ?

• H01J 27/18 - Ion sourcesIon guns using high-frequency excitation, e.g. microwave excitation with an applied axial magnetic field
• H01J 37/08 - Ion sourcesIon guns

Abstract

Provided is a photosensitive composition containing a metal cluster compound capable of realizing miniaturization of circuit patterns.　The present invention pertains to a photosensitive composition containing a metal cluster compound that forms a cluster having a metal element at the center, that is formed from the metal element and a ligand represented by general formula (1), and that optionally contains oxygen and/or a hydroxyl group.　(In formula (1), X1and X2each independently represent a halogen atom, and may be identical or different, and R1, R2, and R3 each independently represent hydrogen or an arbitrarily-defined substituent, and may be identical or different.)

IPC Classes  ?

• G03F 7/004 - Photosensitive materials
• C07C 271/28 - Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
• C07F 9/94 - Bismuth compounds
• G03F 7/20 - ExposureApparatus therefor
• G03F 7/32 - Liquid compositions therefor, e.g. developers

Abstract

For the purpose of providing a technology that makes it possible to dissolve an inorganic substance typified by lithium ore more easily compared with the conventional technologies disclosed in non-patent document 1 and patent document 1, an inorganic substance solution production method (M10) is provided. The method comprises: a mixing step (S101) for mixing an additive with an inorganic substance that undergoes phase change or is thermally decomposed by heating to produce a first mixture; and a heating step (S102) for heating the first mixture at a heating temperature that is equal to or higher than a predetermined temperature to produce a second mixture comprising the inorganic substance and the additive. In the method, the molar ratio of the amount of the additive to that of the inorganic substance in the mixing step (S101) is 0.5 or more. When (1) the inorganic substance is one which undergoes phase change by heating, the predetermined temperature is a temperature at which the phase change occurs. When (2) the inorganic substance is one which is thermally decomposed by heating, the predetermined temperature is a temperature at which the thermal decomposition occurs.

IPC Classes  ?

• C22B 26/12 - Obtaining lithium
• C01D 15/02 - OxidesHydroxides
• C22B 1/02 - Roasting processes
• C22B 3/00 - Extraction of metal compounds from ores or concentrates by wet processes
• C22B 3/06 - Extraction of metal compounds from ores or concentrates by wet processes by leaching in inorganic acid solutions
• C22B 3/12 - Extraction of metal compounds from ores or concentrates by wet processes by leaching in inorganic alkaline solutions
• C22B 4/02 - Light metals

Abstract

Implemented is a signal processing device capable of efficiently correcting the timing of detection in a light receiving element. A signal processing device (30) executes: an acquisition process (S12a) for acquiring, on the basis of output signals (digital detection signals Sb) from a radiation detection device (20) including a plurality of detection units (40(k)), a difference (detection time difference ΔT) between detection times (T) of detection of fluorescence by first and second detection units that have respectively received first and second incoming radiation emitted in mutually opposite directions from a radiation source (SP), and intensities of the fluorescence (fluorescence intensities I) respectively detected by the first and second detection units; and a determination process (S12b) for determining, on the basis of the detection time difference and the fluorescence intensities, a function (F) representing a detection delay time (TD), which is a delay in a detection time corresponding to the fluorescence intensities.

IPC Classes  ?

• G01T 1/20 - Measuring radiation intensity with scintillation detectors
• G01T 1/161 - Applications in the field of nuclear medicine, e.g. in vivo counting

Abstract

Provided is a technique of identifying fluorescence emitted from a measurement target, the measurement accuracy of the technique being improved by processing data also including background light. A fluorescence detection device includes: a first generating section that generates excitation light whose intensity is modulated and which excites a phosphor that emits fluorescence whose intensity varies according to magnetic resonance; and a second generating section that generates a magnetic field or an electromagnetic wave each of which causes the magnetic resonance so that the intensity of the fluorescence emitted from the phosphor is changed.

IPC Classes  ?

• G01R 33/26 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux using optical pumping

Abstract

Provided is a technique of identifying fluorescence emitted from a measurement target, with a simpler device configuration. A fluorescence detection device includes: a generating section that generates pulsed laser light which causes spin polarization and spin relaxation in a phosphor that emits fluorescence whose intensity varies according to magnetic resonance; and a modulating section that modulates the pulse frequency of the pulsed laser light.

IPC Classes  ?

• G01R 33/26 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux using optical pumping

Abstract

The present invention implements a method for manufacturing a material having a nitrogen-vacancy (NV) center with a higher NV center concentration. This method is for manufacturing a material having a heteroelement-vacancy complex defect and includes: a preparation step for preparing a material that includes a heteroelement as an impurity; an electron beam irradiation step for irradiating the material with an electron beam to form vacancies in the material; and a heat treatment step for heating the electron beam-irradiated material to form a heteroelement-vacancy complex defect in the material. The electron beam irradiation step and the heat treatment step are repeated alternately two or more times.

IPC Classes  ?

• C30B 29/04 - Diamond
• C01B 32/28 - After-treatment, e.g. purification, irradiation, separation or recovery

Abstract

2xxZ cubic crystal alloy (wherein 0.8 ≤ x ≤ 1.3 and Z represents a group 13, 14 or 15 element of the periodic table of the elements). This material exhibits strong perpendicular magnetic anisotropy since a tetragonal strain is applied to a cubic crystal alloy, and has both high thermal stability of magnetization necessary for the achievement of high recording density and high spin polarization ratio necessary for high-speed, low-power read of information by means of a magnetoresistive effect. Consequently, this material is suitable for applications to next-generation magnetic memories with high recording density.

IPC Classes  ?

• H10B 61/00 - Magnetic memory devices, e.g. magnetoresistive RAM [MRAM] devices
• H10N 50/10 - Magnetoresistive devices

Abstract

Objective of the present invention is to provide a resin composition having excellent alkaline resistance and a production method of this resin composition. Object of the present invention is to provide an electrochemical device that uses the above-described resin composition and allows improvement of an output power and durability. In order to solve the above-described problem, the resin composition including a structural unit represented by the following formula (1), a resin composition production method thereof, and an electrochemical device using the resin composition, Objective of the present invention is to provide a resin composition having excellent alkaline resistance and a production method of this resin composition. Object of the present invention is to provide an electrochemical device that uses the above-described resin composition and allows improvement of an output power and durability. In order to solve the above-described problem, the resin composition including a structural unit represented by the following formula (1), a resin composition production method thereof, and an electrochemical device using the resin composition, Objective of the present invention is to provide a resin composition having excellent alkaline resistance and a production method of this resin composition. Object of the present invention is to provide an electrochemical device that uses the above-described resin composition and allows improvement of an output power and durability. In order to solve the above-described problem, the resin composition including a structural unit represented by the following formula (1), a resin composition production method thereof, and an electrochemical device using the resin composition, (In the formula, E is a spacer, and represents a benzene ring, a benzene derivative in which at least one atom is substituted with a hydrocarbon group having 1 to 6 carbon atoms, or a carbon chain having at least 2 carbon atoms and optionally including a heteroatom, Im represents an ion conductive group including an imidazole ring, R1 to R5 each independently represent a carbon chain having 1 to 10 carbon atoms and including hydrogen, halogen or a heteroatom, X− represents an anion).

IPC Classes  ?

• C08F 255/02 - Macromolecular compounds obtained by polymerising monomers on to polymers of hydrocarbons as defined in group on to polymers of olefins having two or three carbon atoms
• C08J 5/22 - Films, membranes or diaphragms
• H01M 8/10 - Fuel cells with solid electrolytes
• H01M 8/1004 - Fuel cells with solid electrolytes characterised by membrane-electrode assemblies [MEA]
• H01M 8/1039 - Polymeric electrolyte materials halogenated, e.g. sulfonated polyvinylidene fluorides
• H01M 12/02 - Details

Abstract

Provided are: a transition metal cluster compound that allows miniaturisation of a circuit pattern; a photosensitive composition that contains said compound; and a pattern formation method that uses said photosensitive composition.　This transition metal cluster compound is composed of 2 to 12 transition metal elements and a ligand represented by general formula (1).　[Formula 1] (In formula 1, R1 is a hydrocarbon chain with one or more carbons.)

IPC Classes  ?

• C07C 57/03 - Monocarboxylic acids
• C07C 63/04 - Monocyclic monocarboxylic acids
• C07F 7/00 - Compounds containing elements of Groups 4 or 14 of the Periodic Table
• G03F 7/004 - Photosensitive materials
• G03F 7/20 - ExposureApparatus therefor

Abstract

Provided are: a compound that can achieve refinement of a circuit pattern; a photosensitive composition containing the same; and a pattern formation method using the photosensitive composition.　This pattern formation method uses a photosensitive composition containing a compound formed of a transition-metal element or a poor-metal element, and a carboxy ligand including an alicyclic structure having a double bond.

IPC Classes  ?

• C07F 7/00 - Compounds containing elements of Groups 4 or 14 of the Periodic Table
• C07C 61/22 - Unsaturated compounds having a carboxyl group bound to a six-membered ring
• C07F 9/94 - Bismuth compounds
• G03F 7/004 - Photosensitive materials
• G03F 7/20 - ExposureApparatus therefor
• G03F 7/32 - Liquid compositions therefor, e.g. developers

Abstract

A storage method according to an aspect of the present invention includes storing an intermediate of a radiopharmaceutical composition in an acetate buffer. The intermediate is a complex of a 3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15), 11, 13-triene-3,6,9-triacetic acid (PCTA) and an anti-epidermal growth factor receptor antibody (anti-EGFR antibody). The intermediate is stored for a storage period of not less than 24 hours.

IPC Classes  ?

• A61K 51/10 - Antibodies or immunoglobulinsFragments thereof
• A61K 47/12 - Carboxylic acidsSalts or anhydrides thereof
• A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Abstract

The medical image processing device according to an embodiment has an image acquisition unit, a trajectory generation unit, and a selection unit. The image acquisition unit acquires a plurality of radioscopic images capturing a patient. The trajectory generation unit recognizes the position of a target portion shown in each of the plurality of radioscopic images, and generates a trajectory of a state in which the target portion moves, on the basis of the recognized positions of the target portion. The selection unit selects a tracking method for tracking the target portion on the basis of the trajectory of the target portion.

IPC Classes  ?

• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy
• A61B 34/20 - Surgical navigation systemsDevices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis

Abstract

Provided is an ion generation device that can sequentially supply targets to an irradiation area while removing an impurity layer that can form on the surface of the targets. An ion generation device (10) comprises: an induction heating unit (13) that heats a film-shaped target (TA) that includes a conductor layer by induction; and a laser irradiation unit (laser light source 15, focusing mirror 16b) that irradiates laser light at the target that has been heated by induction and thereby generates ions from the target.

IPC Classes  ?

• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy
• H01J 27/24 - Ion sourcesIon guns using photo-ionisation, e.g. using laser beam

Abstract

The present invention achieves both time resolution and DOI resolution in a radiation detection device that can measure DOI. This scintillator array (11) includes a plurality of scintillator units. Each of the plurality of scintillator units comprises: a first scintillator, the bottom surface of which is optically connected to a light receiving surface of one among two light receiving elements adjacent to each other in a light receiving element array (12); and a second scintillator, at least a portion of the side surface of which is optically connected to at least a portion of the side surface of the first scintillator, and the bottom surface of which is optically connected to a light receiving surface of the other among the two light receiving elements, wherein one side surface or two side surfaces of the first scintillator and the second scintillator are roughened.

IPC Classes  ?

• G01T 1/161 - Applications in the field of nuclear medicine, e.g. in vivo counting
• G01T 1/20 - Measuring radiation intensity with scintillation detectors

Abstract

By a technique different from conventional techniques, quality of an image obtained by nuclear medicine imaging is improved. In an image processing device, a first reconstruction process section generates, by a reconstruction process with respect to list mode data acquired by a PET device, an initial image indicating a concentration distribution of a radioactive substance. A scatter component derivation section derives, from the initial image, scatter component projection data indicating a scatter component of radiation rays by scatter estimation simulation. A second reconstruction process section generates, by a reconstruction process with respect to the scatter component projection data, a low resolution scatter image indicating the scatter component and having a resolution lower than that of the initial image. An upscaling process section generates an upscaled scatter image having a resolution identical with that of the initial image by upscaling the low resolution scatter image.

IPC Classes  ?

• A61B 6/03 - Computed tomography [CT]
• G01T 1/167 - Measuring radioactive content of objects, e.g. contamination
• G01T 1/29 - Measurement performed on radiation beams, e.g. position or section of the beamMeasurement of spatial distribution of radiation

Abstract

The present invention addresses the problem of providing a vibration damping device and a vibration damping method with which it is possible to perform vibration damping of an object to be vibration damped by attenuating vibrations of a mass body, without using a fluid such as oil, grease or a resin-based material in a vibration attenuating mechanism. In order to resolve the abovementioned problem, the present invention provides a vibration damping device for attenuating vibrations of an object to be vibration damped, the vibration damping device being characterized by comprising a mass body that vibrates synchronously with vibrations of the object to be vibration damped, a resilient body that suspends the mass body, and a vibration attenuating mechanism for attenuating the vibrations of the mass body, wherein the vibration attenuating mechanism includes a sliding portion that slides in conjunction with the vibrations of the mass body, and the vibrations of the mass body are attenuated by means of the sliding in the sliding portion.

IPC Classes  ?

• F16F 1/18 - Leaf springs
• G21B 1/25 - Maintenance, e.g. repair or remote inspection
• F16F 15/02 - Suppression of vibrations of non-rotating, e.g. reciprocating, systemsSuppression of vibrations of rotating systems by use of members not moving with the rotating system
• F16F 15/073 - Suppression of vibrations of non-rotating, e.g. reciprocating, systemsSuppression of vibrations of rotating systems by use of members not moving with the rotating system using elastic means with metal springs using only leaf springs

Abstract

Provided are a transition metal cluster compound that enables miniaturization of a circuit pattern; a photosensitive composition containing this compound; and a pattern formation method that uses this photosensitive composition.　The transition metal cluster compound is formed from a transition metal element and a ligand represented by general formula (1).　(In formula (1), X is a halogen element.)

IPC Classes  ?

• C08F 20/06 - Acrylic acidMethacrylic acidMetal salts or ammonium salts thereof
• C08F 2/44 - Polymerisation in the presence of compounding ingredients, e.g. plasticisers, dyestuffs, fillers
• G03F 7/004 - Photosensitive materials
• G03F 7/20 - ExposureApparatus therefor

Abstract

The purpose of the present invention is to achieve quantum metrology which makes it possible to measure the state of the inside of a cell and in which disadvantages of quantum metrology using nano-particles are overcome. The intracellular quantum metrology device (1) is provided with a substrate (10) having a nanopillar (11) formed on the surface thereof, in which the nanopillar (11) is intended to be inserted into a cell (C) and includes a quantum sensor at the tip part thereof.

IPC Classes  ?

• G01N 24/00 - Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
• C12M 1/00 - Apparatus for enzymology or microbiology
• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• G01N 24/08 - Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
• G01N 33/483 - Physical analysis of biological material
• G01R 33/26 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux using optical pumping
• G01R 33/465 - NMR spectroscopy applied to biological material, e.g. in vitro testing

Abstract

The present invention relates to a method for measuring TDP-43 in a biological sample. Non-capture beads used in this method each do not bind to an immune complex of TDP-43 in a biological sample, a capture antibody, and a detection antibody. The immune complex is formed on each of capture beads. At least one of the detection antibody and the capture antibody specifically recognizes the TDP-43. An epitope of the capture antibody and an epitope of the detection antibody differ from each other.

IPC Classes  ?

• G01N 33/543 - ImmunoassayBiospecific binding assayMaterials therefor with an insoluble carrier for immobilising immunochemicals
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

In order to provide a novel production method that produces a solution of an inorganic substance which is poorly soluble in both a basic solution and an acidic solution, and that is highly energy efficient, a method for producing an inorganic substance solution (BeCl2 solution production method M10) includes: a heating step (S13) of dielectrically heating a powdery mixture to obtain a liquid mixture containing an inorganic substance, the powdery mixture having been obtained by mixing powder of the inorganic substance and hydroxide.

IPC Classes  ?

• C01F 3/02 - OxidesHydroxides
• C01D 15/02 - OxidesHydroxides
• C01D 15/08 - CarbonatesBicarbonates
• C22B 1/24 - BindingBriquetting
• C22B 3/10 - Hydrochloric acid

Abstract

Provided is a radionuclide-containing substance administration facility unit which enables good placement of a function for storing radioactive drainage in a radiation control area. This administration facility unit (101) comprises: a floor (2201) provided across a plurality of rooms and having a step structure (2205), a region on one side of the step structure (2205) being at a position higher than a region on the other side of the step structure, and the floor (2201) being provided with a space between the region on one side and the shielding wall; a radioactive drainage storage tank (408) accommodated in the space; and piping (481) that guides the radioactive drainage to the tank (408) from a drainage port (410) provided to the region on one side.

IPC Classes  ?

• G21F 7/00 - Shielded cells or rooms
• G21F 9/22 - Disposal of liquid waste by storage in a tank or other container
• E04H 3/08 - Hospitals, infirmaries, or the likeSchoolsPrisons
• E04B 1/343 - Structures characterised by movable, separable, or collapsible parts, e.g. for transport

Abstract

Provided is an air conditioner capable of easily controlling air-conditioning in a radiation controlled area. An administration facility unit (101) is provided with an air conditioner (430). The air conditioner (430) is provided with an air supply device (450) that supplies air to each of a plurality of rooms in a radiation controlled area, an exhaust device (470) that discharges air from each of the rooms, a piping (491) that provides a bypass between the air supply device (450) and the exhaust device (470), and a flowrate adjust valve (492) that is attached to the piping (491) and that adjusts the amount of air flowing through the piping (491).

IPC Classes  ?

• G21F 7/015 - Room atmosphere, temperature or pressure control devices
• F24F 7/06 - Ventilation with ducting systems with forced air circulation, e.g. by fan
• E04B 1/343 - Structures characterised by movable, separable, or collapsible parts, e.g. for transport

Abstract

The present invention provides a radionuclide-containing substance administration facility in which the function of storing radioactive wastewater can be suitably provided within a radiation-controlled area. An administration facility unit (101) comprises: a floor (2201) that is arranged across a plurality of rooms, has a step structure (2205), has on one side of the step structure (2205) a region located at a higher position than a region on the other side of the step structure, and is provided with a space between the region on the one side and a shielding wall; a radioactive wastewater storage tank (408) accommodated in the space; and a pipe (481) that guides the radioactive wastewater from a drain port (410) provided in the region on the one side to the tank (408).

IPC Classes  ?

• E04H 3/08 - Hospitals, infirmaries, or the likeSchoolsPrisons
• E04B 1/343 - Structures characterised by movable, separable, or collapsible parts, e.g. for transport
• G09F 13/04 - Signs, boards, or panels, illuminated from behind the insignia
• G21F 7/00 - Shielded cells or rooms

Abstract

A novel interleukin-18 (IL-18) variant and a pharmaceutical composition using the same, which relates to a human IL-18 variant including (i) mutations of cysteine at positions 38, 68, 76, and 127 into serine and (ii) mutations of glutamic acid at position 6 and lysine at position 53 into alanine relative to an amino acid sequence of wild-type human IL-18, where the variant further includes (iii) at least one additional mutation, and a pharmaceutical composition containing the human IL-18 variant.

IPC Classes  ?

• C07K 14/54 - Interleukins [IL]
• A61K 38/20 - Interleukins
• C12N 5/0783 - T cellsNK cellsProgenitors of T or NK cells

Abstract

The purpose of the present invention is to produce an intermediate for a radioactive antibody drug having a higher purity. A production method of the present invention includes an adsorption step for adsorbing a composition containing an intermediate on a stationary phase for hydrophobic chromatography, and a purification step for eluting the intermediate from the stationary phase. The intermediate is a complex of an anti-epidermal growth factor receptor antibody (anti-EGFR antibody) and 3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene-3,6,9-triacetic acid (PCTA).

IPC Classes  ?

• A61K 51/04 - Organic compounds
• A61K 51/10 - Antibodies or immunoglobulinsFragments thereof
• A61P 35/00 - Antineoplastic agents

Abstract

According to one embodiment, a superconducting coil apparatus comprising at least one superconducting coil formed of a plurality of turns under a definition that one turn is a portion of a superconducting wire annularly wound for one round, wherein: the superconducting coil has a shape along an outer peripheral surface of a tubular structure having a tubular shape; each of the plurality of turns has a coil longitudinal portion extending along an axial direction of the tubular structure; arrangement form of the coil longitudinal portion is different between a main magnetic field generation region configured to generate a main magnetic field and a magnetic field correction region configured to generate a correction magnetic field.

IPC Classes  ?

• H01F 6/06 - Coils, e.g. winding, insulating, terminating or casing arrangements therefor
• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy

Abstract

One aspect of the present invention relates to a recovery method of 226Ra, and the recovery method of 226Ra includes a step (A1) of immersing a solid-state 226Ra containing substance and a carrier having a function of adsorbing 226Ra ions in a processing solution, and then irradiating the processing solution with ultrasonic waves.

IPC Classes  ?

• C22B 7/00 - Working-up raw materials other than ores, e.g. scrap, to produce non-ferrous metals or compounds thereof
• C22B 60/02 - Obtaining thorium, uranium or other actinides

Abstract

The present invention can improve the detection accuracy of detecting a physical quantity using a quantum sensor. This physical quantity detection device 1 comprises: a quantum sensor 2 which has spin defects 2a; an excitation unit 4 which imparts excitation energy to the spin defects 2a; an electromagnetic wave incident unit 3 which causes a resonant electromagnetic wave for the ground level of the spin defects 2a and a multiphoton absorption electromagnetic wave of the spin defects 2a to be incident to the spin defects 2a; and an optical detection unit 5 which detects the light emission intensity of the spin defects 2a when receiving the excitation energy, the resonant electromagnetic wave for the ground level and multiphoton absorption electromagnetic wave, wherein the physical quantity detection device detects a physical quantity on the basis of the light emission intensity detected by the optical detection unit 5. The multiphoton absorption electromagnetic wave has different frequencies from the resonant electromagnetic wave for the ground level, and is determined on the basis of the resonant electromagnetic wave for the ground level.

IPC Classes  ?

• G01R 33/20 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance
• G01R 33/26 - Arrangements or instruments for measuring magnetic variables involving magnetic resonance for measuring direction or magnitude of magnetic fields or magnetic flux using optical pumping
• G01N 24/10 - Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using electron paramagnetic resonance

Abstract

Provided are a prediction device, a prediction method, and a prediction program that can make predictions from multidimensional time series data at high speed and with high accuracy. A prediction device 1, which analyzes multidimensional time series data regarding a predetermined event, and predicts events from the multidimensional time series data, includes a predictive means for acquiring multidimensional time series data, decomposes the multidimensional time series data into matrix data using dynamic mode decomposition, acquires features from the matrix data, acquires predicted values from the features and weights calculated in advance on the basis of the kernel method, and predicts events from the predicted values.

IPC Classes  ?

• G06N 20/00 - Machine learning

Abstract

A radiation measuring device (1) is a forceps-type radiation measuring device (1) for measuring radiation from internal body tissue, and comprises: a pair of radiation detecting units (10) each provided with a plurality of radiation detecting elements; and an adjusting unit (20) for estimating a position of a radiation source from detected data acquired by the pair of radiation detecting units, and adjusting a detection sensitivity of the pair of radiation detecting units with respect to radiation on the basis of the estimated position of the radiation source.

IPC Classes  ?

• G01T 1/161 - Applications in the field of nuclear medicine, e.g. in vivo counting
• G01T 1/167 - Measuring radioactive content of objects, e.g. contamination
• G01T 1/29 - Measurement performed on radiation beams, e.g. position or section of the beamMeasurement of spatial distribution of radiation

Abstract

An embodiment of the present invention relates to a compound represented by formula (I) or (II), a pharmaceutically acceptable salt thereof, or a solvate thereof. An embodiment of the present invention relates to a compound represented by formula (I) or (II), a pharmaceutically acceptable salt thereof, or a solvate thereof.

IPC Classes  ?

• C07D 417/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• A61K 51/04 - Organic compounds
• A61K 49/00 - Preparations for testing in vivo

Abstract

The medical image processing device according to the present embodiment is provided with a first image acquisition unit, a second image acquisition unit, an area acquisition unit, an image similarity calculation unit, a cost calculation unit, and a registration unit. The first image acquisition unit acquires a first image that is an image of the inside of the body of a patient. The second image acquisition unit acquires a second image that is an image of the inside of the body of the patient which is captured at a time point different from that at which the first image has been captured. The area acquisition unit acquires at least two areas corresponding to the first image or the second image. The image similarity calculation unit calculates the similarity between the first image and the second image. The cost calculation unit calculates cost based on the positional relationship between the areas. The registration unit determines the relative position of the first image relative to the second image in such a manner that the similarity between the images becomes high and the cost becomes low.

IPC Classes  ?

• A61B 6/03 - Computed tomography [CT]
• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy

Abstract

The present invention provides a method for producing a low-molecular-weight polytetrafluoroethylene which has a small variation in the molecular weight. The present invention provides a method for producing a low-molecular-weight polytetrafluoroethylene, the method comprising a step (1) in which a low-molecular-weight polytetrafluoroethylene that has a melt viscosity of 1.0 × 102Pa∙s to 7.0 × 105 Pa∙s at 380°C is obtained by irradiating a high-molecular-weight polytetrafluoroethylene with radiation such that the ratio (maximum dose)/(minimum dose) of the maximum dose to the minimum dose is 1.55 or less.

IPC Classes  ?

• C08F 8/50 - Partial depolymerisation
• C08F 114/26 - Tetrafluoroethene
• C08J 3/28 - Treatment by wave energy or particle radiation

Abstract

A magneto-optical memory interface includes: a memory cell structure having multiple allocated magnetic recording cells, a selection means configured to select an individual or a predetermined number of the multiple allocated magnetic recording cells of the memory structure, and configured for an electronic signal to be applicable thereto; and a light irradiation part configured to irradiate the predetermined number of the multiple allocated magnetic memory cells with an optical signal, wherein each of the magnetic recording cells is a magnetic recording cell whose sensitivity to changes in a magnetization state thereof increases in response to an irradiation light from the light irradiation part, and each of the magnetic recording cells is a magnetic recording cell whose magnetization state changes in response to an applied electrical signal resulting from selection by the selection means and the irradiation light from the light irradiation part.

IPC Classes  ?

• G11C 11/16 - Digital stores characterised by the use of particular electric or magnetic storage elementsStorage elements therefor using magnetic elements using elements in which the storage effect is based on magnetic spin effect
• G11C 13/06 - Digital stores characterised by the use of storage elements not covered by groups , , or using optical elements using magneto-optical elements

Abstract

A method for producing an 225Ac solution includes a step (I) of irradiating a 226Ra target with particles to generate two or more actinium radioisotopes (Ac) including at least 225Ac, a step (II) of dissolving the 226Ra target after the aforementioned step to obtain a solution (1), a step (III) of separating 226Ra and Ac contained in the solution (1) to obtain a solution (2), a step (IV) of allowing Ac contained in the solution (2) other than 225Ac to decay to obtain a solution (3), and a step (V) of separating Ra and Ac contained in the solution (3) to obtain a solution (4). The solution (4) is used to produce a medicine that contains, as an active ingredient, a conjugate between a chelating agent that has formed a complex with 225Ac, and a targeting agent.

IPC Classes  ?

• A61K 51/08 - Peptides, e.g. proteins
• A61K 51/04 - Organic compounds

Abstract

According to an embodiment, a radiation therapy device includes an acquirer, a projection position calculator, an element projection image generator, and an element projection image synthesizer. The acquirer acquires a condition of X-ray imaging in a treatment stage and a three-dimensional image of a patient imaged before the treatment stage. The projection position calculator calculates a projection position when each of pixels included in the three-dimensional image is projected onto a two-dimensional X-ray fluoroscopic image generated in the X-ray imaging on the basis of the condition of the X-ray imaging. The element projection image generator generates an element projection image for each pixel when each of the pixels included in the three-dimensional image is projected onto the X-ray fluoroscopic image. The element projection image synthesizer performs a synthesis process for the element projection image for each pixel on the basis of the projection position to generate a reconstructed image.

IPC Classes  ?

• G06T 7/73 - Determining position or orientation of objects or cameras using feature-based methods
• G06T 15/00 - 3D [Three Dimensional] image rendering
• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy
• G01T 1/17 - Circuit arrangements not adapted to a particular type of detector

Abstract

A method for evaporatively concentrating a radioactive metal nuclide, including: a first evaporative concentration process in which a radioactive solution formed by dissolving a radioactive metal nuclide in an acidic aqueous solution is heated to evaporate a solvent in the radioactive solution so as to obtain a concentrated liquid containing the radioactive metal nuclide; and a second evaporative concentration process in which a low-boiling organic solvent having a lower boiling point than water is added to the concentrated liquid, and the concentrated liquid is heated to induce azeotropic boiling of the concentrated liquid and the low-boiling organic solvent so as to obtain an evaporative concentrate of the radioactive metal nuclide.

IPC Classes  ?

• C07B 59/00 - Introduction of isotopes of elements into organic compounds
• B01D 3/36 - Azeotropic distillation
• B01D 1/14 - Evaporating with heated gases or vapours in contact with the liquid

Abstract

Generation of impurity ions is prevented or reduced in a carbon ion generating device in which a laser-driven ion acceleration system is employed. A carbon ion generating device generates a carbonized region by irradiating a film made of an organic compound with a first laser beam, and generates carbon ions by irradiating at least a part of the carbonized region with a second laser beam.

IPC Classes  ?

• G21K 5/04 - Irradiation devices with beam-forming means
• H01J 27/24 - Ion sourcesIon guns using photo-ionisation, e.g. using laser beam
• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy
• G21K 1/00 - Arrangements for handling particles or ionising radiation, e.g. focusing or moderating

Abstract

According to one embodiment, a superconducting coil apparatus comprising at least one superconducting coil formed of a plurality of turns under a definition that one turn is a portion of a superconducting wire annularly wound for one round, wherein: the superconducting coil has a shape along an outer peripheral surface of a tubular structure having a tubular shape; each of the plurality of turns has a coil longitudinal portion extending along an axial direction of the tubular structure and a coil end portion extending from the coil longitudinal portion along a circumferential direction of the tubular structure; and a boundary line indicating a border between the coil longitudinal portion and the coil end portion at each of the plurality of turns is inclined with respect to a reference line extending in the circumferential direction of the tubular structure in a side view of the tubular structure.

IPC Classes  ?

• H01F 6/06 - Coils, e.g. winding, insulating, terminating or casing arrangements therefor
• H05H 7/00 - Details of devices of the types covered by groups

Abstract

A medical image processing device includes a first image acquiring unit, a second image acquiring unit, a first likelihood distribution calculating unit, a trackability determining unit, and a tracking unit. The first image acquiring unit acquires first images which are transparent images of the patient. The second image acquiring unit acquires second images which are transparent images of the patient generated at a time different from that of the first images. The first likelihood distribution calculating unit calculates a first likelihood distribution indicating a distribution of likelihoods indicating a likeness to the object in the first images. The trackability determining unit determines whether the object is trackable on the basis of the first likelihood distribution. The tracking unit tracks the position of the object in the second images on the basis of the result of determination.

IPC Classes  ?

• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy
• G06T 7/246 - Analysis of motion using feature-based methods, e.g. the tracking of corners or segments
• A61B 90/00 - Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups , e.g. for luxation treatment or for protecting wound edges

Abstract

wnn is 1.5 or less. This makes it possible to obtain particles having a more precisely controlled hydrodynamic diameter. The single polymer is preferably a structure composed of a single hydrophilic polymer A or a structure in which a side chain of one or more hydrophilic polymers B is bonded to a main chain composed of a single hydrophilic polymer A.

IPC Classes  ?

• C08G 81/00 - Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
• A61K 9/08 - Solutions
• A61K 47/34 - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
• A61K 47/56 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
• A61K 47/62 - Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additivesTargeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
• A61K 49/14 - Peptides, e.g. proteins

Abstract

For the purpose of providing a photoresist material having strong resistance to dry etching, this photoresist material according to one embodiment of the present invention is for use in extreme-ultraviolet lithography and comprises a metal oxide precursor or a polymer alloy containing at least one from among polycarbosilanes, polysiloxanes, polysilazanes, and polyorganoborosilazanes.

IPC Classes  ?

• G03F 7/075 - Silicon-containing compounds
• G03F 7/004 - Photosensitive materials
• G03F 7/20 - ExposureApparatus therefor

Abstract

This photosensitive composition includes a tin compound which has three hydrocarbon groups that may have substituent groups and in which a pyridinedicarboxylic acid serves as a ligand. This pattern formation method comprises: a step for forming a photosensitive layer on a substrate by using the photosensitive composition; a step for irradiating a prescribed area of the photosensitive layer with chemoradiation so as to perform pattern exposure; and a step for subjecting the post-exposure photosensitive layer to a development process by a developing solution and selectively removing an exposed part or an unexposed part of the photosensitive layer.

IPC Classes  ?

• G03F 7/004 - Photosensitive materials
• G03F 7/20 - ExposureApparatus therefor
• G03F 7/32 - Liquid compositions therefor, e.g. developers

Abstract

Provided is a radiation detector that can allow an operator to more accurately identify a position of a body tissue into which radionuclides have been taken. A radiation detector includes: a probe which has a radiation detection element housed therein and which is insertable into a body; a reporting part provided to the probe; and a control part configured to cause the reporting part to operate in accordance with a result of detection of radiation, the detection being made by the radiation detection element.

IPC Classes  ?

• A61B 6/42 - Arrangements for detecting radiation specially adapted for radiation diagnosis
• A61B 6/40 - Arrangements for generating radiation specially adapted for radiation diagnosis
• A61B 6/50 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body partsApparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific clinical applications
• A61B 17/29 - Forceps for use in minimally invasive surgery
• G01T 1/161 - Applications in the field of nuclear medicine, e.g. in vivo counting
• G01T 1/20 - Measuring radiation intensity with scintillation detectors

Abstract

An object of the invention is to make it possible to provide a mechanism that applies an external stimulus and to measure structural and electromagnetic changes of a cell due to the external stimulus with high sensitivity by an NV center. There is provided an environment control mechanism configured to change a state of a sample by applying an external stimulus to the sample.

IPC Classes  ?

• C12M 1/34 - Measuring or testing with condition measuring or sensing means, e.g. colony counters
• C12M 1/12 - Apparatus for enzymology or microbiology with sterilisation, filtration, or dialysis means
• C12M 1/42 - Apparatus for the treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic wave
• G01N 21/64 - FluorescencePhosphorescence

Abstract

Provided is a compound constituted from a heteropolyacid anion, a photoreactive cation represented by formula (1), and a hydrogen cation. Also provided is a photosensitive composition containing this compound. (In formula (1), R1and R2 are each independently an optionally substituted linear saturated aliphatic hydrocarbon group having 1-10 carbon atoms, linear unsaturated aliphatic hydrocarbon group having 2-10 carbon atoms or aromatic group having 3-10 carbon atoms. Q is an optionally substituted saturated aliphatic hydrocarbon chain or aromatic chain. G is a substituent group having a monovalent cation.)

IPC Classes  ?

• C07C 381/12 - Sulfonium compounds
• G03F 7/004 - Photosensitive materials
• G03F 7/20 - ExposureApparatus therefor
• G03F 7/32 - Liquid compositions therefor, e.g. developers

Abstract

A medical image processing device of an embodiment comprises a first image acquisition unit, a second image acquisition unit, a shift unit, and a display control unit. The first image acquisition unit acquires a first three-dimensional fluoroscopic image that is a three-dimensional fluoroscopic image of a patient imaged in a patient treatment planning step. The second image acquisition unit acquires a second three-dimensional fluoroscopic image that is a three-dimensional fluoroscopic image of the patient imaged in a patient treatment step. The shift unit shifts the display center position of the second three-dimensional fluoroscopic image by adding a prescribed amount to the imaging center position of the second three-dimensional fluoroscopic image. The display control unit displays, on a display device, a sectional image of the second three-dimensional fluoroscopic image so that the display center position of the second three-dimensional fluoroscopic image is made to be the center of a display area in a position determination step in the patient treatment step.

IPC Classes  ?

• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy

Abstract

A medical image processing device of one embodiment of the present invention includes a first image acquisition unit, a second image acquisition unit, a 3D-3D positioning execution unit, and a display control unit. The first image acquisition unit acquires a first three-dimensional perspective image, which is a three-dimensional perspective image of a patient. The second image acquisition unit acquires a second three-dimensional perspective image, which is a three-dimensional perspective image of the patient. The 3D-3D positioning execution unit calculates a first deviation amount between the first three-dimensional perspective image and the second three-dimensional perspective image. The display control unit causes a display device to display: a first DRR image which is generated from the second three-dimensional perspective image that has been corrected on the basis of the first deviation amount; and a two-dimensional perspective image of the patient.

IPC Classes  ?

• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy

Abstract

Provided are: an image recognition program that can accurately count the number of nematodes as detection targets, even when a plurality of the detection targets overlap; an image recognition device using the same; a detection target number counting method; and a model image creation device for image recognition training used therefor. The image recognition program causes a control unit 11 and a storage unit 12 of an image recognition device 1 to function as: a detection target image acquisition means for acquiring a detection target image in which a plurality of nematodes 3 appear; an extraction means for extracting, from the detection target image, a detection target presence region which may include an image of the nematodes 3; a storage means for storing a plurality of pattern images, including a single pattern image in which one of the nematodes 3 appears, and a multiple pattern image, which is an image in which two or more of the nematodes 3 appear in an overlapping manner; and a recognition means tor detecting the degree of match between an image of the detection target presence region and each pattern image to recognize the number of the nematodes 3 included in the detection target presence region.

IPC Classes  ?

• G06T 7/00 - Image analysis
• G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers
• G01N 33/483 - Physical analysis of biological material

Abstract

The present invention addresses the problem of providing a microscope objective lens, an attachment for a microscope objective lens, and a microscope, which make it possible to position an electromagnetic wave application antenna easily, rapidly, highly accurately, and with high reproducibility when applying an electromagnetic wave under a microscope.　In order to solve the problem, provided are a microscope objective lens provided with an antenna for applying an electromagnetic wave to an object to be observed in front of a lens surface, an attachment for a microscope objective lens provided with an antenna, and a microscope using the microscope objective lens or a microscope objective lens equipped with the attachment for the microscope objective lens.　According to this characteristic, by providing the electromagnetic wave application antenna directly or indirectly on the microscope objective lens side, it becomes possible to position the electromagnetic wave application antenna easily, rapidly, highly accurately, and with high reproducibility in conjunction with the adjustment of the positions of the microscope objective lens and the object to be observed.

IPC Classes  ?

• G02B 21/00 - Microscopes
• G01B 21/02 - Measuring arrangements or details thereof, where the measuring technique is not covered by the other groups of this subclass, unspecified or not relevant for measuring length, width, or thickness
• G01N 21/64 - FluorescencePhosphorescence
• G01N 24/00 - Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects

Abstract

Provided is a compound that has high binding selectivity to α-synuclein aggregates.　The present invention relates to a compound represented by formula (I), (II) or (III), a pharmaceutically acceptable salt thereof, or a solvate of the compound or pharmaceutically acceptable salt.

IPC Classes  ?

• C07D 417/06 - Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
• A61K 31/4427 - Non-condensed pyridinesHydrogenated derivatives thereof containing further heterocyclic ring systems
• A61K 31/497 - Non-condensed pyrazines containing further heterocyclic rings
• A61K 51/00 - Preparations containing radioactive substances for use in therapy or testing in vivo
• A61P 25/16 - Anti-Parkinson drugs
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• A61P 43/00 - Drugs for specific purposes, not provided for in groups

Abstract

The present invention provides a laser-accelerated particle beam device and a laser-accelerated particle beam generation method which achieve a reduction in fluctuation of a light focusing position when an irradiation angle is changed. To this end, provided is a laser-accelerated particle beam device (10) that generates a particle beam by exciting a target (15, 21) with laser light, said laser-accelerated particle beam device comprising an aperture mask (12) that has an aperture that allows part of the laser light to pass therethrough, and a concave mirror (14) that reflects the laser light which has passed through the aperture of the aperture mask and causes the laser light to converge at a focal point (F0) set within the target, wherein the aperture mask is movable in a direction that intersects the laser light which passes through the aperture mask.

IPC Classes  ?

• H01J 37/06 - Electron sourcesElectron guns
• H01J 37/08 - Ion sourcesIon guns
• H05H 15/00 - Methods or devices for acceleration of charged particles not otherwise provided for
• G21K 5/04 - Irradiation devices with beam-forming means
• H01S 3/00 - Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range

Abstract

A medical image processing device of an embodiment of the present invention includes a first image acquisition unit, a second image acquisition unit, a treatment error acquisition unit, a difference calculation unit, and a difference-statistics calculation unit. The first image acquisition unit acquires a first transparent image which captures the inside of a patient's body. The second image acquisition unit acquires a second transparent image of inside the patient's body captured at a different time than that of the first transparent image. The treatment error acquisition unit acquires a treatment error that occurs during treatment or when performing position alignment processing. On the basis of the treatment error, the difference calculation unit calculates a difference image between the second transparent image in which a virtual perturbation is applied to the position of the captured patient and the first transparent image. The difference-statistics calculation unit calculates difference-statistics between the first transparent image and the second transparent image on the basis of the difference image.

IPC Classes  ?

• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy

Abstract

The present invention enables an improvement in the detection accuracy of physical quantity detection employing a quantum sensor. A physical quantity detecting device 1 comprises a quantum sensor 2 having a spin defect 2a, an excitation unit 4 for imparting excitation energy to the spin defect 2a, an electromagnetic wave incidence unit 3 for causing a resonant electromagnetic wave for a ground state of the spin defect 2a and an electromagnetic wave for an excited state of the spin defect 2a to be incident on the spin defect 2a, and a light detecting unit 5 for detecting an intensity of light emitted by the spin defect 2a upon receipt of the excitation energy, the ground state resonant electromagnetic wave and the excited state electromagnetic wave, wherein a physical quantity is detected on the basis of the emitted light intensity detected by the light detecting unit 5.

IPC Classes  ?

• G01N 24/10 - Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using electron paramagnetic resonance

Abstract

The present invention makes it easy to derive a relationship between coordinates relating to a distribution of radiation emitted from an interior of an object and coordinates relating to an external shape of the object. A relationship (R) between first coordinates (Ca) and third coordinates (Cc) is derived on the basis of first 3D data (Da) in which a distribution of radiation emitted from an interior of an object (subject P) is represented by the first coordinates, second 3D data (Db) in which an interior and an external shape of the object is represented by second coordinates (Cb), and third 3D data (Dc) in which at least a portion of the external shape of the object is represented by the third coordinates.

IPC Classes  ?

• G01T 1/161 - Applications in the field of nuclear medicine, e.g. in vivo counting

Abstract

An image is reconstituted by iterative approximation, a PET event updated image is produced by updating a current image using a PET event, a Compton event updated image is produced by updating the current image using a Compton event, the PET event updated image and the Compton event updated image that have been independently produced are weighted and added together, and the current image is updated using an image obtained by addition processing. In this way, PET events and Compton events, which have different properties, can be used in combination to efficiently and stably reconstitute images, improving image quality.

IPC Classes  ?

• A61B 6/03 - Computed tomography [CT]
• G06T 7/00 - Image analysis
• G06T 11/00 - 2D [Two Dimensional] image generation
• A61B 6/00 - Apparatus or devices for radiation diagnosisApparatus or devices for radiation diagnosis combined with radiation therapy equipment
• G01N 23/20066 - Measuring inelastic scattering of gamma rays, e.g. Compton effect

Abstract

Disclosed a particle accelerator that accelerates a charged particle beam while circulating the charged particle beam as a circulating beam and outputs some of the circulating beam as an output beam, the particle accelerator including: a first deflection section and a second deflection sections each having a deflection electromagnet; a first straight section, a second straight section, and third straight section each not having the deflection electromagnet; and a control unit, wherein a preceding output deflector of the first straight section deflects some of the circulating beam toward an inner side of a circulating trajectory of the circulating beam to separate the some of the circulating beam as an output beam, wherein a succeeding output deflector of the third straight section deflects the output beam separated from the circulating beam by the preceding output deflector toward an outer side of the circulating trajectory of the circulating beam, and wherein the control unit controls at least the quadrupole electromagnet such that a phase advance of a betatron oscillation of the output beam is 270±45 degrees in a section from the preceding output deflector to the succeeding output deflector.

IPC Classes  ?

• H05H 7/04 - Magnet systemsEnergisation thereof
• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy
• H05H 7/00 - Details of devices of the types covered by groups
• H05H 13/04 - Synchrotrons

Abstract

A nematode-sealed capsule according to the present disclosure includes: a sealing composition containing nematodes; and at least one film containing the sealing composition. The film contains, as a main component, a water-soluble polymer which is gelled through a reaction with a cation.

IPC Classes  ?

• C12N 11/04 - Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
• C12Q 1/02 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving viable microorganisms
• G01N 33/48 - Biological material, e.g. blood, urineHaemocytometers

Abstract

[Problem] To develop an artificial catalyst capable of inhibiting aggregation of pathogenic amyloids (tau amyloids) formed by the aggregation of tau proteins, and to provide a prophylactic and therapeutic medicine for amyloid-related diseases using the same. [Solution] It is found that a compound having a structure, wherein an electron acceptor moiety containing a specific thiazole ring is linked to an electron donor moiety by intramolecular conjugation, is useful as a novel biocatalyst capable of selectively oxygenating tau amyloids upon the irradiation with light and preventing the aggregation thereof. It is also found that the aforesaid compound has excellent blood-brain barrier penetration properties and enables the oxygenation of tau amyloids in the brain upon the irradiation with light from the outside of the body.

IPC Classes  ?

• C07D 513/04 - Ortho-condensed systems
• A61K 31/4985 - Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
• A61K 41/00 - Medicinal preparations obtained by treating materials with wave energy or particle radiation
• A61P 25/28 - Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• C07D 519/00 - Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or

Abstract

A large electron tube (1) is provided with: a cylindrical collector (14); and, a magnetic body (16) disposed outside the collector (14) and having no axial symmetry with respect to the central axis of the collector (14). With the above configuration, parasitic oscillation occurring inside the collector (14) can be suppressed.

IPC Classes  ?

• H01J 23/075 - Magnetron injection guns
• H01J 23/10 - Magnet systems for directing or deflecting the discharge along a desired path, e.g. a spiral path
• H01J 25/00 - Transit-time tubes, e.g. klystrons, travelling-wave tubes, magnetrons

Abstract

According to an embodiment, a medical image processing device includes a first image acquirer, a second image acquirer, a direction acquirer, and a movement amount calculator. The first image acquirer acquires a three-dimensional first image obtained by photographing the inside of a body of a patient. The second image acquirer acquires a three-dimensional second image of the inside of the body of the patient imaged at a timing different from that of the first image. The direction acquirer acquires information about an irradiation direction of radiation to the patient in a treatment room. The movement amount calculator outputs a movement amount signal indicating the amount of movement of the second image to be moved to align the position of the patient shown in the second image with the position of the patient shown in the first image based on the path of the radiation set in the first image and the information about the irradiation direction.

IPC Classes  ?

• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy
• G06T 7/20 - Analysis of motion

Abstract

f) held by the holding mechanism (2) or the anode (3), or both, around the axis of the wound substrate (90).

IPC Classes  ?

• C25D 17/06 - Suspending or supporting devices for articles to be coated
• C25D 5/02 - Electroplating of selected surface areas
• C25D 5/10 - Electroplating with more than one layer of the same or of different metals
• C25D 7/06 - WiresStripsFoils
• C25D 17/00 - Constructional parts, or assemblies thereof, of cells for electrolytic coating
• C25D 17/02 - TanksInstallations therefor
• C25D 17/12 - Shape or form
• C25D 21/10 - Agitating of electrolytesMoving of racks

Abstract

In order to provide a greater efficiency in exciting a target than conventionally possible in technology for using laser-induced plasma shock waves to excite the target, an excitation device is provided with a condenser lens (12), and a shock tube (11) in which one end (11a1) of an interior space (11a) is sealed using the condenser lens (12) and another end (11a2) of the interior space (11a) is open. The condenser lens (12) causes a supplied laser (L) to be condensed in the interior space (11a) of the shock tube (11). The shock tube (11) outputs laser-induced plasma shock waves from the other end (11a2).

IPC Classes  ?

• G01M 7/02 - Vibration-testing
• G01N 29/04 - Analysing solids

Abstract

Provided are: a particle beam irradiation apparatus that makes it possible to shorten the distance between a patient and an irradiation field forming appliance of the particle beam irradiation apparatus; and an energy modulation device for use in the particle beam irradiation apparatus. This energy modulation device is for use in a particle beam irradiation apparatus 10 which transports, by using a beam transport line 2, charged particle beams extracted from an accelerator 1 and which performs irradiation by a scanning method by using scanning electromagnets 4, 5. In other words, the energy modulation device is a ripple filter 7. The ripple filter 7 comprises filter members 70 each having a plurality of opening parts 72 which penetrate in the thickness direction and through which at least some of the charged particle beams pass. Two or more of the filter members 70 are disposed so as to be laminated in the thickness direction.

IPC Classes  ?

• G21K 3/00 - Ionising radiation filters, e.g. X-ray filters
• G21K 5/04 - Irradiation devices with beam-forming means
• A61N 5/10 - X-ray therapyGamma-ray therapyParticle-irradiation therapy

Abstract

Provided is a separation and purification method comprising: a step (1) for adjusting a sample solution including a first metal ion, a second metal ion, and a chelating agent to a pH at which the second metal ion chelates to form a complex having a negative charge, while the first metal ion essentially does not chelate; a step (2-1) for bringing a solution containing the first metal ion and the chelated second metal ion obtained in step (1) into contact with a cation exchange body, and adsorbing the first metal ion in the solution on the cation exchange body to remove the first metal ion; a step (2-2) for obtaining a treated solution containing the chelated second metal ion, from which the first metal ion has been removed; and a step (3) for decomposing the chelating agent for the chelated second metal ion contained in the treated solution obtained in step (2-2), to obtain a purified second metal ion. This separation and purification method is suitable when the second metal is a radioisotope obtained by conversion from the first metal.

IPC Classes  ?

• G21G 4/08 - Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical applications
• C22B 3/24 - Treatment or purification of solutions, e.g. obtained by leaching by physical processes, e.g. by filtration, by magnetic means by adsorption on solid substances, e.g. by extraction with solid resins
• B01J 39/05 - Processes using organic exchangers in the strongly acidic form
• B01J 39/07 - Processes using organic exchangers in the weakly acidic form
• B01J 39/09 - Inorganic material
• B01J 39/20 - Macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
• B01J 39/22 - Cellulose or woodDerivatives thereof
• B01J 47/02 - Column or bed processes
• B01J 47/14 - Controlling or regulating
• B01J 49/00 - Regeneration or reactivation of ion-exchangersApparatus therefor
• B01J 49/20 - Regeneration or reactivation of ion-exchangersApparatus therefor of membranes

Abstract

This invention provides a pulse shaping technique that can yield a pulsed laser having a smaller energy fluctuation than that of a conventional pulse shaping technique using one or two non-linear optical crystals. A pulse shaping device includes: a non-linear optical crystal group including at least three non-linear optical crystals arranged side by side on an optical path of an input pulsed laser.

IPC Classes  ?

• H01S 3/10 - Controlling the intensity, frequency, phase, polarisation or direction of the emitted radiation, e.g. switching, gating, modulating or demodulating
• H01S 3/00 - Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range
• H01S 3/16 - Solid materials
• G02F 1/355 - Non-linear optics characterised by the materials used

Abstract

Provided is technology which identifies fluorescence emitted from a measurement target, and the measurement accuracy of which is improved as a result of performing data processing including background light. This fluorescence detection device (1) comprises: a first generation unit (11) that generates excitation light which has a modulated intensity, which excites a phosphor, and the fluorescence intensity of which varies according to magnetic resonance; and a second generation unit (12) that generates a magnetic field or electromagnetic waves for generating magnetic resonance and altering the intensity of the fluorescence emitted from the phosphor.

IPC Classes  ?

• G01N 21/64 - FluorescencePhosphorescence
• G01N 24/10 - Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using electron paramagnetic resonance

Abstract

Provided is a technology for identifying fluorescence emitted from a measurement target, using a simpler device configuration. A fluorescence detecting device (1) comprises: a generating unit (11) for generating laser pulsed light for generating spin polarization and spin relaxation in a fluorescent material having a fluorescence intensity that is varied by means of magnetic resonance; and a modulating unit (12) for performing pulse frequency modulation of the laser pulsed light.

IPC Classes  ?

• G01N 21/64 - FluorescencePhosphorescence
• G01N 24/10 - Investigating or analysing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using electron paramagnetic resonance

Abstract

Provided is a laser device in which: a laser medium doped with ytterbium emits light upon absorption of excitation light; the light emitted by the laser medium is amplified to obtain output light; and the output light is outputted in the form of a plurality of pulses. In the laser device, a spatial filter is disposed in the optical path of the light emitted by the laser medium or is disposed in the optical path of the output light outputted from an optical resonator, the spatial filter being configured to filter out a portion of the light or of the output light around the optical axis.

IPC Classes  ?

• H01S 3/094 - Processes or apparatus for excitation, e.g. pumping using optical pumping by coherent light
• H01S 3/04 - Arrangements for thermal management
• H01S 3/042 - Arrangements for thermal management for solid state lasers
• H01S 3/06 - Construction or shape of active medium
• H01S 3/08045 - Single-mode emission
• H01S 3/0805 - Transverse or lateral modes by apertures, e.g. pin-holes or knife-edges
• H01S 3/0941 - Processes or apparatus for excitation, e.g. pumping using optical pumping by coherent light of a semiconductor laser, e.g. of a laser diode
• H01S 3/113 - Q-switching using intracavity saturable absorbers
• H01S 3/16 - Solid materials
• H01S 5/00 - Semiconductor lasers
• H01S 3/00 - Lasers, i.e. devices using stimulated emission of electromagnetic radiation in the infrared, visible or ultraviolet wave range

Abstract

A layered structure which achieves both high spin polarization and low electrical resistance is provided. The layered structure includes a Heusler alloy, and graphene that is in direct contact with the surface of the Heusler alloy. Such a layered structure is fabricated by forming a thin film of the Heusler alloy over a substrate under vacuum, and growing graphene on the surface of the thin film of the Heusler alloy while maintaining the vacuum.

IPC Classes  ?

• H01L 29/82 - Types of semiconductor device controllable by variation of the magnetic field applied to the device
• H10B 61/00 - Magnetic memory devices, e.g. magnetoresistive RAM [MRAM] devices
• H10N 50/01 - Manufacture or treatment
• H10N 50/80 - Constructional details