The invention relates to biologically functional scaffolds having a porous structure, methods of preparing, and methods of use thereof. The invention also relates to methods of repairing a defect, methods of culturing cells and promoting differentiation of stem cells using the same.
The present invention provides a soft tissue composite. The soft tissue composite comprises a first collagen fiber bundle of a first soft tissue isolated from a first donor and a polymeric material, and the first collagen fiber bundle interconnects with the polymeric material. The soft tissue may be a sandwich composite comprising a first layer comprising a first collagen fiber bundler, a second layer comprising a polymeric material, and a third layer comprising a third collagen fiber bundles, and the second layer is between the first and third layers, and the first collagen fiber bundler, the polymeric material and the third collagen fiber bundler interconnect with each other. Also provided is a method of repairing a defective tissue in a subject with the soft tissue composite and a method of preparing the soft tissue composite.
A61L 27/48 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
A61L 27/18 - Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
The present invention is directed to methods for collecting and processing autografts, processed autografts, kits for collecting and transporting autografts, and tools for preparing autografts. It is also directed to autologous bone grafts, and methods of preparing them.
Soft tissue supports, soft tissue implants, and methods of making and using soft tissue supports are disclosed. One soft tissue support includes a unitary piece of processed porous tissue material having an anterior portion and a posterior portion. The anterior and posterior portions define a cavity therebetween. The cavity is sized to receive a breast implant therein. The cavity has at least one opening sized to receive the breast implant therethrough. One soft tissue implant includes the soft tissue support and a breast implant positioned within the cavity of the soft tissue support. The implant may further include a soft tissue graft configured to support the processed porous tissue material and the breast implant. A method of using a soft tissue support includes inserting a breast implant into the soft tissue support, and implanting the soft tissue support containing the breast implant in the cavity.
The present invention provides a product comprising plated human hepatocytes on a surface and at least some of the plated hepatocytes are in one or more hepatocyte clusters on feeder cells, which are attached to the surface. A method of preparing plated human hepatocytes is also provided. The preparation method comprises applying human hepatocytes to a surface in the presence of feeder cells, co-culturing the applied hepatocytes with the feeder cells, and forming one or more hepatocyte clusters by the co-cultured hepatocytes on the feeder cells, which are attached to the surface. The plated hepatocytes may be used for various purposes, including the preparation of a hepatitis B virus (HBV) infected hepatocyte culture model and drug testing.
A system and method for processing a tubular tissue sample defining a lumen and an exterior surface. The system includes a container having a one or more walls defining a hollow interior chamber for receiving the tubular tissue sample. A first fluid inlet passage is associated with the container and configured to direct fluid through the lumen of the tissue sample. A second fluid inlet passage is also associated with the container and configured to direct fluid over the exterior surface of the tissue sample.
The present invention is directed to methods for collecting and processing autografts, processed autografts, kits for collecting and transporting autografts, and tools for preparing autografts. It is also directed to autologous bone grafts, and methods of preparing them.
The invention relates to medical implants, including spinal implants and bone grafts, for fixation and integration with hard tissue. The bone medical implants include at least one rotational fixation mechanism that further includes or is attached to one or more sharp protrusions configured to penetrate and become lodged into hard tissue to provide support and positional stability. Such support is useful to ensure that the spinal bone graft may be used without additional stabilizing or anchoring structures, such as supporting plates or screws.
The present invention provides a product comprising plated human hepatocytes on a surface and at least some of the plated hepatocytes are in one or more hepatocyte clusters on feeder cells, which are attached to the surface. The plated human hepatocytes may be neonatal, juvenile, or adult hepatocytes. The product may include macrophage, e.g., liver- derived macrophage (e.g., Kupffer cells), or other hepatic non-parenchymal cells (NPCs) (e.g., stellate cells or liver endothelial cells). A method of preparing the plated human hepatocytes is provided. The method includes applying human hepatocytes to a surface in the presence of feeder cells, co-culturing the applied hepatocytes with the feeder cells, and forming one or more hepatocyte clusters by the co-cultured hepatocytes on the feeder cells, which are attached to the surface. The plated hepatocytes may be used for various purposes, such as preparation of a hepatitis B virus (HBV) infected hepatocyte culture model and drug testing.
The present invention provides a thyrocyte product comprising viable thyrocytes isolated from one or more thyroid tissues, wherein the isolated thyrocytes have been cryopreserved. Also provided is a method for preparing a thyrocyte product. Further provided is a method for preparing a thyrocyte culture, comprising (a) seeding thyrocytes onto a surface in a culture vessel, wherein the thyrocytes are isolated from one or more thyroid tissues and have been cryopreserved; and (b) growing the thyrocytes in a growth medium, whereby a thyrocyte culture comprising cultured thyrocytes is prepared. The thyrocytes may form microtissues attached to the surface in a 3D culture. The cultured thyrocytes may form a monolayer in direct contact with the surface in a 2D culture. A method of testing drugs and other molecules for thyroid bioactivity is also provided.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Human allograft tissue; biological tendon tissue intended for implantation; human allograft tissue for orthopedic use; human allograft tissue for use in joint reconstruction, anterior cruciate ligament repair, and posterior cruciate ligament repair
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Plasticized human cadaveric bone grafts, and plasticized human cadaveric soft tissue grafts namely tendon, ligament, fascia lata, skin, dura mater, pericardium, for implantation into a patient to repair a defect or injury
05 - Pharmaceutical, veterinary and sanitary products
40 - Treatment of materials; recycling, air and water treatment,
Goods & Services
(1) Human cadaveric tissue and bone tissue for implantation to correct a defect or injury (1) Treating and processing of human bone and tissue to be used for implantation
The present invention provides a bone graft such as an allograft and a method for releasing growth factors from tissues (e.g., bone marrow, bone matrix, periosteum, and/or endosteum) having native living cells. Also provided are a composition comprising the growth factors and the uses of the composition for improving osteoinductivity of an implant, for example, bone graft.
C07K 14/51 - Bone morphogenic factorOsteogeninOsteogenic factorBone-inducing factor
A61L 27/48 - Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
A spinal bone graft includes one or more cortical bone portions forming a first unit. The first unit includes an engagement surface for contacting bone, and a mating surface. The mating surface forms at least one first undercut. The bone graft also includes one or more cortical bone portions forming a second unit. The second unit includes an engagement surface for contacting bone, and a mating surface. The mating surface forms either at least one second undercut, or at least one connector. In the former, at least one connector is received in each of the first and second undercuts to interconnect the first and second units. In the latter, the at least one connector of the second unit is received in the first undercut of the first unit to interconnect the first unit and second unit.
The present invention provides a birth tissue derived implant for treating a subject. The birth tissue derived implant comprises a birth tissue and an agent exogenous to the birth tissue. The birth tissue is isolated from an amniotic sac, an umbilical cord or a placental plate. A method is also provided for repairing a defective tissue in a subject. The repair method comprises delivering the birth tissue derived implant to a surface of the defective tissue in the subject. The defective tissue may be an ocular membrane, a synovium, tendon, ligament, nerve, a cartilage or a bone. A method is further provided for preparing the birth tissue derived implant. The preparation method may comprise devitalizing or decellula rizing a birth tissue from an amniotic sac, an umbilical cord or a placental plate, and adding an agent to the devitalized or decellularized birth tissue.
The present invention provides demineralized bone fibers exhibiting optimal handling properties (e.g., high moldability and low elastic modulus) and biological activities (e.g., osteoinductivity) as well as non-demineralized bone fibers useful for preparing the demineralized bone fibers. A well-controlled demineralization process for preparing the demineralized bone of fibers is also provided. Products comprising the demineralized bone fibers and uses thereof are further provided.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Human allograft tissue; Human allograft tissue for wound care; Human allograft tissue for treatment of chronic wounds; Human allograft tissue for treatment of diabetic foot ulcers, venous stasis ulcers, arterial ulcers, pressure ulcers, dehisced surgical wounds, and burns
28.
PACKAGING ASSEMBLY FOR STORING TISSUE AND CELLULAR MATERIAL
An improved packaging assembly for storing, distributing, treating, mixing, and dispensing tissue and/or cellular material and/or implantable material. The packaging assembly may include pouches, tubes, and a bag made of a sealable, flexible polymeric material that is open at one end and a needle-free swabable connector attached to the pouch at the other end and acting as a port to allow for the introduction or discharge of biological solutions, rinsing solution, and/or preservation solutions into the packaging assembly. The designed thickness of the wall of the packaging assembly facilitates efficient heat/cold transfer, which is useful for successful controlled rate freezing, quick thawing, and resuscitation of viable cells or tissue. The packaging assembly is also useful for combining additional biological fluids with the cellular material or tissue, and for efficient mixing of the biological fluids with the tissue and/or cellular material in the assembly.
B65D 39/08 - Threaded or like closure members secured by rotationBushes therefor
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
The present invention provides a soft tissue composite. The soft tissue composite comprises a first collagen fiber bundle of a first soft tissue isolated from a first donor and a polymeric material, and the first collagen fiber bundle interconnects with the polymeric material. The soft tissue may be a sandwich composite comprising a first layer comprising a first collagen fiber bundler, a second layer comprising a polymeric material, and a third layer comprising a third collagen fiber bundles, and the second layer is between the first and third layers, and the first collagen fiber bundler, the polymeric material and the third collagen fiber bundler interconnect with each other. Also provided is a method of repairing a defective tissue in a subject with the soft tissue composite and a method of preparing the soft tissue composite.
42 - Scientific, technological and industrial services, research and design
Goods & Services
General toxicology consulting; pharmaceutical drug
development services; design for others in the field of cell
culture in vitro products; laboratory services in the fields
of pharmaceuticals, chemicals, and personal-care products,
namely, safety screening, determination and prediction of
chemical toxicity, and risk assessment; development of new
products for others in the field of in vitro toxicology
tools and biochemical toxicology solutions.
The present invention provides a cannula for delivering a tissue graft to a treatment site. The cannula comprises a distal end, a proximal end, a bore formed by an interior surface of the cannula, extending from the distal end to the proximal end and having a diameter, and a tissue graft inside the bore and in contact with the interior surface. The tissue graft may be released from the cannula at the distal end to the treatment site. The tissue graft may have a final loading pressure of 20-200 psi. Also provided is a delivery system comprising the cannula and a delivery device. Further provided are methods for delivering a tissue graft in a cannula to a treatment site and methods for preparing a cannula loaded with the tissue graft.
42 - Scientific, technological and industrial services, research and design
Goods & Services
(1) General toxicology consulting; pharmaceutical drug development services; design for others in the field of cell culture in vitro products; laboratory services in the fields of pharmaceuticals, chemicals, and personal-care products, namely, safety screening, determination and prediction of chemical toxicity, and risk assessment; development of new products for others in the field of in vitro toxicology tools and biochemical toxicology solutions.
33.
PLACENTA-DERIVED MATRIX AND METHODS OF PREPARING AND USE THEREOF
The invention relates to placenta-derived matrix, methods of preparing, and methods of use thereof. The invention also relates to methods of culturing cells, delivering cells, promoting differentiation of stem cells or tissue-specific progenitor cells, and repairing, replacing, regenerating, filling, reducing or inhibiting scarring of defects using the same. The invention further relates to methods of coating placenta-derived matrix on a surface or injecting the placenta-derived matrix into a site of interest.
A system and method for processing a tubular tissue sample defining a lumen and an exterior surface. The system includes a container having a one or more walls defining a hollow interior chamber for receiving the tubular tissue sample. A first fluid inlet passage is associated with the container and configured to direct fluid through the lumen of the tissue sample. A second fluid inlet passage is also associated with the container and configured to direct fluid over the exterior surface of the tissue sample.
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Providing a website featuring medical information; Providing a website featuring medical information regarding medical devices, implants, and tissue grafts; Providing medical information and news about medical devices, implants, and tissue grafts through photos, videos, and clinical literature
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
09 - Scientific and electric apparatus and instruments
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Cells for scientific, laboratory, and medical research use; Cell culture media for scientific, laboratory, and research use; biological tissue, namely, bone, blood, muscle, organ, skin and vascular tissue for scientific, laboratory, and medical research use; in vitro assays for scientific, laboratory, and medical research use; in vitro assays for drug research use; human cells, biological tissue being bone, blood, muscle, organ, skin and vascular tissue, and in vitro assays for scientific and medical research use for drug discovery and development applications, and toxicity research studies Human allograft tissue and cells; biological bone, skin, placental, amnion, chorion, umbilical cord, tendons, cartilage, veins, arteries, heart valves, and cardiovascular tissues intended for subsequent implantation; human allograft tissue for use in vascular surgery and vascular treatment; human allograft tissue for orthopedic use; human allograft tissue for use in burn and wound treatment; human allograft tissue for use in treatment of musculoskeletal disorders and conditions; Cells for medical or clinical use; Cell growth media for growing cells for medical or clinical use; medical diagnostic reagents; Dressings and bandages for skin wounds; Wound healing system comprised of medical dressing and bandages for skin wounds; Medical dressings; Gauze for dressings; Burn dressings; Surgical dressings; Medical dressings for negative pressure wound therapy; Pharmaceutical preparations for wounds; Pharmaceutical preparations for dermatological conditions; Balms for pharmaceutical purposes; medical ointments for treating dermatological conditions, burns, pain and topical infections; Medicated lotions for body; Pharmaceutical preparations for skin care; Pharmaceutical preparations for pain relief; Antibiotics; anti-infectives; anti-fungal pharmaceutical preparations Bioreactors for laboratory use Testing, inspection or research of pharmaceuticals; medical research; scientific research; Providing medical testing services and information in the field of cancer research and disease classification; Toxicology services; pharmaceutical drug development services; pharmaceutical research services; testing of pharmaceuticals; scientific laboratory services; laboratory research and analysis in the fields of pharmaceuticals, chemicals, and personal care products; product safety laboratory testing services in the fields of pharmaceuticals, chemicals, and personal care products, namely, safety screening, determination and prediction of chemical toxicity, and risk assessment; Scientific research and design in the field of in-vitro products for scientific, laboratory, and medical research use; Scientific and technological services, namely, product design in the field of in vitro cell cultures for others; development of new products for others in the field of in vitro toxicology tools and biochemical toxicology solutions Oncology testing services, namely, cancer screening services; Medical testing services relating to the diagnosis and treatment of disease and cancer; Providing medical testing services and information in the field of oncology
38.
COMPRESSED BONE COMPOSITION AND METHODS OF USE THEREOF
The present disclosure relates to compressed bone compositions, bone implants, and variants thereof. The present disclosure also relates to methods of preparing compressed bone compositions, bone implants, and variants thereof. The present disclosure also relates to methods of using the bone compositions, bone implants and variants thereof.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Human allograft tissue; biological tissue intended for subsequent implantation; human allograft tissue for use in vascular surgery and vascular treatment; human allograft tissue for orthopaedic use; human allograft tissue for use in burn and wound treatment; human allograft tissue for use in treatment of musculoskeletal disorders and conditions.
40.
Plated hepatocytes and preparation and uses thereof
The present invention provides a product comprising plated human hepatocytes on a surface and at least some of the plated hepatocytes are in one or more hepatocyte clusters on feeder cells, which are attached to the surface. A method of preparing plated human hepatocytes is also provided. The preparation method comprises applying human hepatocytes to a surface in the presence of feeder cells, co-culturing the applied hepatocytes with the feeder cells, and forming one or more hepatocyte clusters by the co-cultured hepatocytes on the feeder cells, which are attached to the surface. The plated hepatocytes may be used for various purposes, including the preparation of a hepatitis B virus (HBV) infected hepatocyte culture model and drug testing.
The present invention is directed to methods for collecting and processing autografts, processed autografts, kits for collecting and transporting autografts, and tools for preparing autografts. It is also directed to autologous bone grafts, and methods of preparing them.
The invention relates to biologically functional scaffolds having a porous structure, methods of preparing, and methods of use thereof. The invention also relates to methods of repairing a defect, methods of culturing cells and promoting differentiation of stem cells using the same.
A spinal bone graft includes one or more cortical bone portions forming a first unit. The first unit includes an engagement surface for contacting bone, and a mating surface. The mating surface forms at least one first undercut. The bone graft also includes one or more cortical bone portions forming a second unit. The second unit includes an engagement surface for contacting bone, and a mating surface. The mating surface forms either at least one second undercut, or at least one connector. In the former, at least one connector is received in each of the first and second undercuts to interconnect the first and second units. In the latter, the at least one connector of the second unit is received in the first undercut of the first unit to interconnect the first unit and second unit.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Human allograft tissue; biological tendon tissue intended for implantation; human allograft tissue for orthopedic use; human allograft tissue for use in joint reconstruction, anterior cruciate ligament repair, and posterior cruciate ligament repair
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Human allograft tissue; biological bone tissue intended for subsequent implantation; human allograft tissue for orthopedic use; human allograft tissue for use in osteotomies, bone fusion, and bone fracture repair
The invention relates to interbody spacers constructed of allograft material. These allograft implants include a first plank of allograft that has a first fusion surface and a first mating surface, opposite the first fusion surface. A second plank of allograft includes second fusion surface and a second mating surface, opposite the second fusion surface. At least one interior plank of allograft has a third mating surface attached to the first mating surface, and a fourth mating surface opposite the third mating surface, attached to the second mating surface. At least one transverse connector interconnects the first, second, and interior planks of the allograft implants. The allograft implants may have at least one transverse passage, and transverse connectors may interconnect the planks through this passage. The ends of transverse connectors may be flush with the fusion surfaces, and those ends may comprise patterned projections.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Bone growth and bone regenerative media consisting of biological materials for dental and craniomaxillofacial medical purposes, none of which is to be used in the field of human or animal reproduction.
51.
AORTOILIAC IMPLANT AND PROCESSING AND USES THEREOF
The present invention provides a package comprising an aortoiliac artery graft and a record of a measured pressurized diameter of the aortoiliac artery graft, which measurement has been determined ex vivo under a pressure. A method of processing an aortoiliac artery graft is also provided. The processing method comprises subjecting an aortoiliac artery to a pressure ex vivo, and determining a measured pressurized diameter of the aortoiliac artery under the pressure. A method of treating abdominal aortic aneurysm, infected aortoiliac endograft or a traumatically damaged abdominal aorta or an iliac artery in a patient is further provided. The treatment method comprises anastomosing a processed aortoiliac artery graft with an aorta of the patient on the proximal end and the iliac or femoral arteries on the distal end, wherein a measured pressurized diameter of the processed aortoiliac artery graft has been determined ex vivo under a pressure.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
42 - Scientific, technological and industrial services, research and design
44 - Medical, veterinary, hygienic and cosmetic services; agriculture, horticulture and forestry services
Goods & Services
Cells for scientific, laboratory, and medical research use; Cell culture media for scientific, laboratory, and research use; biological tissue, namely, bone, blood, muscle, organ, skin and vascular tissue for scientific, laboratory, and medical research use; in vitro assays for scientific, laboratory, and medical research use; in vitro assays for drug research Cells for medical or clinical use; Cell growth media for growing cells for medical or clinical use; in vitro diagnostic reagents and assays for medical or clinical use Testing, inspection or research of pharmaceuticals; medical research; scientific research; Providing medical testing services and information in the field of oncology; Providing medical testing services and information in the field of disease and cancer treatment Oncology testing services, namely, cancer screening services; Medical testing services relating to the diagnosis and treatment of disease and cancer
53.
DECELLULARIZED PLACENTAL MEMBRANE AND METHODS OF PREPARING AND USE THEREOF
A method of preparing a decellularized placental membrane is provided. The method comprises removing cells from a pre-decellularized placental membrane comprising an amnion layer and a chorion layer to produce a decellularized placental membrane without separating the amnion layer from the chorion layer. The pre-decellularized placental membrane is obtained from an amniotic sac, and the decellularized placental membrane comprises the amnion layer and the chorion layer. Also provided is a decellularized placental membrane and a placenta-derived graft comprising the decellularized placental membrane. Further provided are the uses of the decellularized placental membrane or the placenta-derived graft.
Soft tissue supports, soft tissue implants, and methods of making and using soft tissue supports are disclosed. One soft tissue support includes a unitary piece of processed porous tissue material having an anterior portion and a posterior portion. The anterior and posterior portions define a cavity therebetween. The cavity is sized to receive a breast implant therein. The cavity has at least one opening sized to receive the breast implant therethrough. One soft tissue implant includes the soft tissue support and a breast implant positioned within the cavity of the soft tissue support. The implant may further include a soft tissue graft configured to support the processed porous tissue material and the breast implant. A method of using a soft tissue support includes inserting a breast implant into the soft tissue support, and implanting the soft tissue support containing the breast implant in the cavity.
The present invention provides a composition for treating a pathological condition in a body part of a patient in needed thereof, comprising an effective amount of a birth tissue elute or birth tissue particulates. A method for preparing the birth tissue elute, for example, an umbilical cord elute, is also provided. A method for treating a pathological condition in a body part of a patient in needed thereof is further provided.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Human allograft tissue; biological tissue intended for
subsequent implantation; human allograft tissue for use in
vascular surgery and vascular treatment; human allograft
tissue for orthopedic use; human allograft tissue for use in
burn and wound treatment; human allograft tissue for use in
treatment of musculoskeletal disorders and conditions.
01 - Chemical and biological materials for industrial, scientific and agricultural use
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
human cells, biological tissue, and in vitro assays for scientific and medical research use for drug discovery and development applications, and toxicity research studies human cells, human allograft tissue, and medical diagnostic reagents and in vitro assays for medical purposes for use in drug testing
60.
Medical implant for fixation and integration with hard tissue
The invention relates to medical implants, including spinal implants and bone grafts, for fixation and integration with hard tissue. The bone medical implants include at least one rotational fixation mechanism that further includes or is attached to one or more sharp protrusions configured to penetrate and become lodged into hard tissue to provide support and positional stability. Such support is useful to ensure that the spinal bone graft may be used without additional stabilizing or anchoring structures, such as supporting plates or screws.
The present invention provides a cannula for delivering a tissue graft to a treatment site. The cannula comprises a distal end, a proximal end, a bore formed by an interior surface of the cannula, extending from the distal end to the proximal end and having a diameter, and a tissue graft inside the bore and in contact with the interior surface. The tissue graft may be released from the cannula at the distal end to the treatment site. The tissue graft may have a final loading pressure of 20-200 psi. Also provided is a delivery system comprising the cannula and a delivery device. Further provided are methods for delivering a tissue graft in a cannula to a treatment site and methods for preparing a cannula loaded with the tissue graft.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
(1) Human allograft tissue; biological placental, amnion, chorion, and umbilical cord tissue intended for subsequent implantation; human allograft tissue for orthopedic use.
The present invention provides a package comprising an aortoiliac artery graft and a record of a measured pressurized diameter of the aortoiliac artery graft, which measurement has been determined ex vivo under a pressure. A method of processing an aortoiliac artery graft is also provided. The processing method comprises subjecting an aortoiliac artery to a pressure ex vivo, and determining a measured pressurized diameter of the aortoiliac artery under the pressure. A method of treating abdominal aortic aneurysm, infected aortoiliac endograft or a traumatically damaged abdominal aorta or an iliac artery in a patient is further provided. The treatment method comprises anastomosing a processed aortoiliac artery graft with an aorta of the patient on the proximal end and the iliac or femoral arteries on the distal end, wherein a measured pressurized diameter of the processed aortoiliac artery graft has been determined ex vivo under a pressure.
A shaped cartilage matrix isolated from a human or animal where the cartilage has been crafted to facilitate disinfection, cleaning, devitalization, recellularization, and/or integration after implantation. Also, a process for repairing a cartilage defect with the cartilage matrix. The matrix is in the form of an osteochondral plug including a cartilage cap ad subchondral bone, wherein one or more gaps, slats, bores, or channels extend through the tidemark at the interface between the cartilage cap and the subchondral bone.
The invention is directed towards a process for implanting a cartilage graft into a cartilage defect and sealing the implanted cartilage graft with recipient tissue by creating a first bore down to the bone portion of the cartilage defect, creating a second shaped bore that is concentric to and on top of the first bore to match the shape and size of the cartilage graft, treating the first bore and the second shaped bore at the defect site with a bonding agent, treating the circumferential area of the cartilage graft with a bonding agent, inserting the cartilage graft into the defect site and wherein the superficial surface of the cartilage graft is at the same height as the surrounding cartilage surface. The first and second bonding agents may be activated by applying a stimulation agent to induce sealing, integration, and restoration of the hydrodynamic environments of the recipient tissue. The invention is also directed towards a process for repairing a cartilage defect and implanting a cartilage graft into a human or animal by crafting a cartilage matrix into individual grafts, cleaning and disinfecting the cartilage graft, applying a pretreatment solution to the cartilage graft, removing cellular debris using an extracting solution to produce a devitalized cartilage graft, implanting the cartilage graft into the cartilage defect with or without an insertion device, and sealing the implanted cartilage graft with recipient tissue. The devitalized cartilage graft is optionally recellularized in vitro, in vivo, or in situ with viable cells to render the tissue vital before or after the implantation. The devitalized cartilage graft is also optionally stored between the removing cellular debris and the recellularizing steps. The invention is further directed toward a repaired cartilage defect.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Human allograft tissue; biological bone, skin, placental, amnion, chorion, umbilical cord, tendons, cartilage, veins, arteries, heart valves, and cardiovascular tissues intended for subsequent implantation; biological cell tissues of bone, skin, placental, amnion, chorion, umbilical cord, tendons, cartilage, veins, arteries, and heart valves intended for subsequent implantation; human allograft tissue for use in vascular surgery and vascular treatment; human allograft tissue for orthopedic use; human allograft tissue for use in burn and wound treatment; human allograft tissue for use in treatment of musculoskeletal disorders and conditions
The present invention provides demineralized bone fibers exhibiting optimal handling properties (e.g., high moldability and low elastic modulus) and biological activities (e.g., osteoinductivity) as well as non-demineralized bone fibers useful for preparing the demineralized bone fibers. A well-controlled demineralization process for preparing the demineralized bone of fibers is also provided. Products comprising the demineralized bone fibers and uses thereof are further provided.
Soft tissue grafts, packaged soft tissue grafts, and methods of making and using soft tissue grafts are disclosed. One soft tissue graft includes processed tissue material having first and second opposed surfaces. The first and second opposed surfaces are bounded by first and second edges. The first edge has a concave shape that curves toward the second edge. The second edge has a convex shape that curves away from the first edge. The first surface comprises a plurality of apertures. At least one of the apertures is formed from a multi-directional separation in the first surface. One method of making a soft tissue graft includes positioning a cutting die on a surface of tissue material, pressing the cutting die into the tissue material to cut the tissue material, and processing the cut tissue material to create processed tissue material.
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Human allograft tissue; biological placental, amnion, chorion, and umbilical cord tissue intended for subsequent implantation; human allograft tissue for orthopedic use
75.
Packaging assembly for storing tissue and cellular material
An improved packaging assembly for storing, distributing, treating, mixing, and dispensing tissue and/or cellular material and/or implantable material. The packaging assembly may include pouches, tubes, and a bag made of a sealable, flexible polymeric material that is open at one end and a needle-free swabable connector attached to the pouch at the other end and acting as a port to allow for the introduction or discharge of biological solutions, rinsing solution, and/or preservation solutions into the packaging assembly. The designed thickness of the wall of the packaging assembly facilitates efficient heat/cold transfer, which is useful for successful controlled rate freezing, quick thawing, and resuscitation of viable cells or tissue. The packaging assembly is also useful for combining additional biological fluids with the cellular material or tissue, and for efficient mixing of the biological fluids with the tissue and/or cellular material in the assembly.
A61M 5/00 - Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular wayAccessories therefor, e.g. filling or cleaning devices, arm rests
B65D 39/00 - Closures arranged within necks or pouring openings or in discharge apertures, e.g. stoppers
B65D 39/08 - Threaded or like closure members secured by rotationBushes therefor
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Human allograft tissue; biological artery and vessel tissue intended for subsequent implantation; human allograft tissue for use in vascular surgery and vascular treatment
78.
Methods for collecting and processing autografts, processed autografts, kits for collecting and transporting autografts, and tools for preparing autografts
The present invention is directed to methods for collecting and processing autografts, processed autografts, kits for collecting and transporting autografts, and tools for preparing autografts. It is also directed to autologous bone grafts, and methods of preparing them.
Disclosed herein are dynamic multi-organ plates comprising two or more wells, wherein the wells are configured for cell or tissue culture growth; at least one transwell tube in fluid communication with the two or more wells; and a pump in fluid communication with the at least one transwell tube.
A spinal bone graft includes one or more cortical bone portions forming a first unit. The first unit includes an engagement surface for contacting bone, and a mating surface. The mating surface forms at least one first undercut. The bone graft also includes one or more cortical bone portions forming a second unit. The second unit includes an engagement surface for contacting bone, and a mating surface. The mating surface forms either at least one second undercut, or at least one connector. In the former, at least one connector is received in each of the first and second undercuts to interconnect the first and second units. In the latter, the at least one connector of the second unit is received in the first undercut of the first unit to interconnect the first unit and second unit.
The invention relates to interbody spacers constructed of allograft material. These allograft implants include a first plank of allograft that has a first fusion surface and a first mating surface, opposite the first fusion surface. A second plank of allograft includes a second fusion surface and a second mating surface, opposite the second fusion surface. At least one interior plank of allograft has a third mating surface attached to the first mating surface, and a fourth mating surface opposite the third mating surface, attached to the second mating surface. At least one transverse connector interconnects the first, second, and interior planks of the allograft implants. The allograft implants may have at least one transverse passage, and transverse connectors may interconnect the planks through this passage. The ends of transverse connectors may be flush with the fusion surfaces, and those ends may comprise patterned projections.
The present disclosure relates to compressed bone compositions, bone implants, and variants thereof. The present disclosure also relates to methods of preparing compressed bone compositions, bone implants, and variants thereof. The present disclosure also relates to methods of using the bone compositions, bone implants and variants thereof.
A scaffold comprising an aligned fiber. Further, a scaffold comprising one or more electrospun fibers wherein a fast Fourier transform (FFT) analysis result of the fibers have adjacent major peaks with about 180° apart from each other. Also, methods for promoting differentiation of stem cells into osteoblasts, chondrocytes, ligament or tendon, the method comprising culturing the cells on the scaffold or aligned fiber in conditions suitable for the cell differentiation.
The present invention provides a composition for treating a pathological condition in a body part of a patient in needed thereof, comprising an effective amount of a birth tissue elute or birth tissue particulates. A method for preparing the birth tissue elute, for example, an umbilical cord elute, is also provided. A method for treating a pathological condition in a body part of a patient in needed thereof is further provided.
Soft tissue supports, soft tissue implants, and methods of making and using soft tissue supports are disclosed. One soft tissue support includes a unitary piece of processed porous tissue material having an anterior portion and a posterior portion. The anterior and posterior portions define a cavity therebetween. The cavity is sized to receive a breast implant therein. The cavity has at least one opening sized to receive the breast implant therethrough. One soft tissue implant includes the soft tissue support and a breast implant positioned within the cavity of the soft tissue support. The implant may further include a soft tissue graft configured to support the processed porous tissue material and the breast implant. A method of using a soft tissue support includes inserting a breast implant into the soft tissue support, and implanting the soft tissue support containing the breast implant in the cavity.
A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
The present invention provides a product comprising plated human hepatocytes on a surface and at least some of the plated hepatocytes are in one or more hepatocyte clusters on feeder cells, which are attached to the surface. A method of preparing plated human hepatocytes is also provided. The preparation method comprises applying human hepatocytes to a surface in the presence of feeder cells, co-culturing the applied hepatocytes with the feeder cells, and forming one or more hepatocyte clusters by the co-cultured hepatocytes on the feeder cells, which are attached to the surface. The plated hepatocytes may be used for various purposes, including the preparation of a hepatitis B virus (HBV) infected hepatocyte culture model and drug testing.
A pin made of cortical bone may be inserted into adjoining bones of a toe to align and secure the bones. The pin may have barbs to prevent migration of the pin. The pin may include a shoulder to further prevent migration of the pin from the bones, to increase the strength of the pin, and to increase the surface area between the bone pin and the host bone. The pin may further include flattened portions on its circumference to aide in rotating the pin during insertion. The pin may be treated to reduce brittleness.
A61B 17/16 - Instruments for performing osteoclasisDrills or chisels for bonesTrepans
A61F 2/42 - Joints for wrists or anklesJoints for hands, e.g. fingersJoints for feet, e.g. toes
89.
Methods for collecting and processing autografts, processed autografts, kits for collecting and transporting autografts, and tools for preparing autografts
The present invention is directed to methods for collecting and processing autografts, processed autografts, kits for collecting and transporting autografts, and tools for preparing autografts. It is also directed to autologous bone grafts, and methods of preparing them.
A spinal bone graft includes one or more cortical bone portions forming a first unit. The first unit includes an engagement surface for contacting bone, and a mating surface. The mating surface forms at least one first undercut. The bone graft also includes one or more cortical bone portions forming a second unit. The second unit includes an engagement surface for contacting bone, and a mating surface. The mating surface forms either at least one second undercut, or at least one connector. In the former, at least one connector is received in each of the first and second undercuts to interconnect the first and second units. In the latter, the at least one connector of the second unit is received in the first undercut of the first unit to interconnect the first unit and second unit.
The present invention provides demineralized bone fibers exhibiting optimal handling properties (e.g., high moldability and low elastic modulus) and biological activities (e.g., osteoinductivity) as well as non-demineralized bone fibers useful for preparing the demineralized bone fibers. A well-controlled demineralization process for preparing the demineralized bone of fibers is also provided. Products comprising the demineralized bone fibers and uses thereof are further provided.
Tissue repair compositions, particularly bone repair compositions, containing demineralized bone fragments and homogenized connective tissues, and methods for making the same. The compositions can be used in the form of an injectable gel, an injectable paste, a paste, a putty, or a rehydratable freeze-dried form.
A scaffold comprising an aligned fiber. Further, a scaffold comprising one or more electrospun fibers wherein a fast Fourier transform (FFT) analysis result of the fibers have adjacent major peaks with about 180° apart from each other. Also, methods for promoting differentiation of stem cells into osteoblasts, chondrocytes, ligament or tendon, the method comprising culturing the cells on the scaffold or aligned fiber in conditions suitable for the cell differentiation.
A61K 38/17 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from animalsPeptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from humans
The invention relates to truncated growth factors and variants thereof. The invention also relates to methods of making and using the truncated growth factors. The invention further relates to compositions including a protease and a growth factor comprising a bone morphogenic protein (BMP) or a variant thereof. The invention also relates to methods of using the composition.
The present invention provides a product comprising plated human hepatocytes on a surface and at least some of the plated hepatocytes are in one or more hepatocyte clusters on feeder cells, which are attached to the surface. A method of preparing plated human hepatocytes is also provided. The preparation method comprises applying human hepatocytes to a surface in the presence of feeder cells, co-culturing the applied hepatocytes with the feeder cells, and forming one or more hepatocyte clusters by the co-cultured hepatocytes on the feeder cells, which are attached to the surface. The plated hepatocytes may be used for various purposes, including the preparation of a hepatitis B virus (HBV) infected hepatocyte culture model and drug testing.
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Dressings and bandages for skin wounds; Wound healing system comprised of dressing and bandages for skin wounds; Cellular and/or tissue-based products for skin wounds in the nature of human allograft tissue including cells and extracellular matrix and biological xenograft tissue including cells and extracellular matrix intended for subsequent transplant in and/or on humans; Medical dressings; Gauze for dressings; Burn dressings; Surgical dressings; Medical dressings for negative pressure wound therapy; Skin grafts; Pharmaceutical preparations for wounds; Medical ointments for treating burns, pain and/or infection; Pharmaceutical preparations for pain relief; Antibacterial anti-fungal and anti-infective pharmaceuticals; anti-fungal pharmaceuticals
05 - Pharmaceutical, veterinary and sanitary products
Goods & Services
Dressings and bandages for skin wounds; Wound healing system comprised of dressing and bandages for skin wounds; Medical dressings; Gauze for dressings; Burn dressings; Surgical dressings; Medical dressings for negative pressure wound therapy; Pharmaceutical preparations for wounds; Pharmaceutical preparations for epidermis care; Balms for pharmaceutical purposes; medical ointments for treating dermatological conditions, burns, pain and/or infection; Medicated lotions for pharmaceutical purposes; Pharmaceutical preparations for skincare; Pharmaceutical preparations for pain relief; Antibacterial anti-fungal and anti-infective pharmaceuticals; anti-fungal pharmaceuticals
The present invention provides a cartilage matrix having a high decellularization level arid a low glycosaminoglycan (GAG) content. The cartilage matrix exhibits desirable characteristics, for example, cohesiveness, tackiness and malleability, for use in cartilage repair. Also provided is a method of preparing the cartilage matrix, comprising decellularizing a cartilage to generate a decellularized cartilage, and deglycosylating the decellularized cartilage.
