Abstract

A combination therapy for treating pulmonary hypertension (e.g., PAH, PH-ILD) includes a dose of treprostinil comprising greater than 10 micrograms of treprostinil and a dose of an ActRIIA fusion protein. The dose of treprostinil and the dose of ActRIIA fusion protein may be administered concurrently or sequentially. Further methods for treating pulmonary hypertension include administering a therapeutically effective amount of ActRIIA fusion protein to a subject who has received a composition containing treprostinil, or administering a composition containing treprostinil to a subject who has received a therapeutically effective amount of ActRIIA fusion protein. The treprostinil may be administered as a dry7 powder or liposomal composition.

IPC Classes  ?

• A61K 9/14 - Particulate form, e.g. powders
• C07K 14/71 - ReceptorsCell surface antigensCell surface determinants for growth factorsReceptorsCell surface antigensCell surface determinants for growth regulators
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

A dry powder inhalation treatment for pulmonary arterial hypertension includes a dose of dry particles comprising greater than 25 micrograms of treprostinil enclosed in a capsule. The dry particles can include treprostinil, a wetting agent, a hydrophobicity modifying agent, a pH modifying agent and a buffer. A method of treating a patient having pulmonary arterial hypertension includes providing a patient a dry powder inhaler, providing the patient at least one capsule for use in the dry powder inhaler, the capsule including at least 25 micrograms of treprostinil.

IPC Classes  ?

• A61K 31/557 - Eicosanoids, e.g. leukotrienes
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 31/5575 - Eicosanoids, e.g. leukotrienes having a cyclopentane ring, e.g. prostaglandin E2, prostaglandin F2-alpha
• A61K 47/02 - Inorganic compounds
• A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• A61P 9/12 - Antihypertensives

Goods & Services

Pharmaceuticals and natural remedy preparations for the treatment of respiratory diseases and for systemic delivery via inhalation; Medicinal preparations and substances for the treatment of respiratory diseases and for systemic delivery via inhalation; Pharmaceutical preparations for inhalation for the treatment of pulmonary hypertension and interstitial lung disease, and idiopathic pulmonary fibrosis; Pharmaceutical preparations for inhalation for the treatment of pulmonary hypertension; pharmaceutical preparations for the treatment of pulmonary hypertension; Pharmaceuticals for treatment of respiratory diseases, namely, capsules comprised of microparticles and nanoparticles, comprised of polymers, excipients, therapeutics, and biologics sold as a kit with inhaler Inhalers for medical use, sold empty; Nebulizers for medical purposes; Instruments and apparatus provided empty used for the inhalation of pharmaceuticals; Medical apparatus for facilitating the inhalation of pharmaceutical preparations

Goods & Services

Pharmaceuticals for treatment of respiratory diseases, namely, pharmaceuticals in the form of capsules comprised of microparticles and nanoparticles composed of polymers, excipients, therapeutics, and biologics; Pharmaceuticals for treatment of respiratory diseases, namely, pharmaceuticals in the nature of microparticles and nanoparticles with prophylactic properties composed of polymers, excipients, therapeutics, and biologics;

Goods & Services

Biological preparations in the nature of microparticles and nanoparticles comprised of polymers and excipients, used for the manufacture of medical and pharmaceutical goods and for general scientific and research purposes; Custom manufacture of microparticles and nanoparticles, namely, those composed of polymers, excipients, therapeutics, and biologics, for general scientific and research purposes; Custom manufacture of microparticles and nanoparticles, namely, those composed of polymers, excipients, therapeutics, and biologics used for the manufacture of medical and pharmaceutical goods and for general scientific and research purposes; custom manufacture of microparticles and nanoparticles, namely, those composed of polymers, excipients, therapeutics, and biologics used for medical diagnostic and treatment purposes;

Goods & Services

Pharmaceutical preparations for inhalation for the treatment of pulmonary hypertension; pharmaceutical preparations for the treatment of pulmonary hypertension

Abstract

A dry powder inhalation treatment for pulmonary arterial hypertension includes a dose of dry particles comprising greater than 25 micrograms of treprostinil enclosed in a capsule. The dry particles can include treprostinil, a wetting agent, a hydrophobicity modifying agent, a pH modifying agent and a buffer. A method of treating a patient having pulmonary arterial hypertension includes providing a patient a dry powder inhaler, providing the patient at least one capsule for use in the dry powder inhaler, the capsule including at least 25 micrograms of treprostinil.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 31/557 - Eicosanoids, e.g. leukotrienes
• A61K 31/5575 - Eicosanoids, e.g. leukotrienes having a cyclopentane ring, e.g. prostaglandin E2, prostaglandin F2-alpha
• A61P 9/12 - Antihypertensives
• A61K 47/02 - Inorganic compounds
• A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Goods & Services

Business administration of patient support programs and medication financial assistance programs; business administration of drug voucher programs; provision of consumer information in the field of patient financial assistance and support; providing patient support programs, namely, business administration of a program for enabling participants to obtain reduced payment of pharmaceuticals; providing patient assistance programs, namely, business administration of copay assistance programs and prescription voucher programs; Providing information about medication insurance coverage, financial patient support enrollment, and patient financial assistance; providing financial support to eligible patients for the purpose of assistance with pharmaceutical expenses; providing information about healthcare insurance plans and patient financial assistance; providing information about the financial administration of patient support programs; providing patient support programs, namely, financial coordination with patients for reduced payment of pharmaceuticals; providing patient assistance programs in the nature of assisting eligible participants with payment of pharmaceutical products; financial administration of medication assistance programs in the nature of providing financial assistance for patients; providing financial information with respect to pharmaceutical payment; Charitable patient assistance program support services, namely, a patient assistance program to provide prescription pharmaceuticals at reduced or no cost for eligible low-income patients and providing medical information about access to medication; patient assistance support services, namely, providing medical assistance information about medication; patient assistance program to provide drugs free of charge to low-income patients without prescription drug coverage; patient assistance program to provide drugs free of charge to low-income patients with prescription drug coverage; providing medical information about medical assistance patient support programs, medications, and prescriptions;

Goods & Services

Business administration of patient support programs and medication financial assistance programs; business administration of drug voucher programs; provision of consumer information in the field of patient financial assistance and support; providing patient support programs, namely, business administration of a program for enabling participants to obtain reduced payment of pharmaceuticals; providing patient assistance programs, namely, business administration of copay assistance programs and prescription voucher programs; Providing information about medication insurance coverage, financial patient support enrollment, and patient financial assistance; providing financial support to eligible patients for the purpose of assistance with pharmaceutical expenses; providing information about healthcare insurance plans and patient financial assistance; providing information about the financial administration of patient support programs; providing patient support programs, namely, financial coordination with patients for reduced payment of pharmaceuticals; providing patient assistance programs in the nature of assisting eligible participants with payment of pharmaceutical products; financial administration of medication assistance programs in the nature of providing financial assistance for patients; providing financial information with respect to pharmaceutical payment; Charitable patient assistance program support services, namely, a patient assistance program to provide prescription pharmaceuticals at reduced or no cost for eligible low-income patients and providing medical information about access to medication; patient assistance support services, namely, providing medical assistance information about medication; patient assistance program to provide drugs free of charge to low-income patients without prescription drug coverage; patient assistance program to provide drugs free of charge to low-income patients with prescription drug coverage; providing medical information about medical assistance patient support programs, medications, and prescriptions;

Goods & Services

Pharmaceutical preparations for inhalation for the treatment of pulmonary hypertension; pharmaceutical preparations for the treatment of pulmonary hypertension

Goods & Services

Pharmaceutical products development; Development of pharmaceutical and biological preparations and medicines; Research and development in the pharmaceutical and biotechnology fields

Goods & Services

Pharmaceutical and biopharmaceutical preparations and substances for the treatment of pulmonary hypertension and respiratory diseases

Goods & Services

Pharmaceutical products development; Development of pharmaceutical and biological preparations and medicines; Research and development in the pharmaceutical and biotechnology fields

Goods & Services

Pharmaceutical and biopharmaceutical preparations and substances for the treatment of pulmonary hypertension and respiratory diseases

Abstract

A dry powder inhalation treatment for pulmonary arterial hypertension includes a dose of dry particles comprising greater than 25 micrograms of treprostinil enclosed in a capsule. The dry particles can include treprostinil, a wetting agent, a hydrophobicity modifying agent, a pH modifying agent and a buffer. A method of treating a patient having pulmonary arterial hypertension includes providing a patient a dry powder inhaler, providing the patient at least one capsule for use in the dry powder inhaler, the capsule including at least 25 micrograms of treprostinil.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 9/12 - Antihypertensives
• A61K 31/557 - Eicosanoids, e.g. leukotrienes
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 31/5575 - Eicosanoids, e.g. leukotrienes having a cyclopentane ring, e.g. prostaglandin E2, prostaglandin F2-alpha
• A61K 47/02 - Inorganic compounds
• A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Abstract

A dry powder inhalation treatment for pulmonary arterial hypertension includes a dose of dry particles comprising greater than 25 micrograms of treprostinil enclosed in a capsule. The dry particles can include treprostinil, a wetting agent, a hydrophobicity modifying agent, a pH modifying agent and a buffer. A method of treating a patient having pulmonary arterial hypertension includes providing a patient a dry powder inhaler, providing the patient at least one capsule for use in the dry powder inhaler, the capsule including at least 25 micrograms of treprostinil.

IPC Classes  ?

• A61K 31/5575 - Eicosanoids, e.g. leukotrienes having a cyclopentane ring, e.g. prostaglandin E2, prostaglandin F2-alpha
• A61P 9/12 - Antihypertensives
• A61K 31/557 - Eicosanoids, e.g. leukotrienes
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 47/02 - Inorganic compounds
• A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Abstract

A dry powder inhalation treatment for pulmonary arterial hypertension includes a dose of dry particles comprising greater than 25 micrograms of treprostinil enclosed in a capsule. The dry particles can include treprostinil, a wetting agent, a hydrophobicity modifying agent, a pH modifying agent and a buffer. A method of treating a patient having pulmonary arterial hypertension includes providing a patient a dry powder inhaler, providing the patient at least one capsule for use in the dry powder inhaler, the capsule including at least 25 micrograms of treprostinil.

IPC Classes  ?

• A61K 31/5575 - Eicosanoids, e.g. leukotrienes having a cyclopentane ring, e.g. prostaglandin E2, prostaglandin F2-alpha
• A61P 9/12 - Antihypertensives
• A61K 31/557 - Eicosanoids, e.g. leukotrienes
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 47/02 - Inorganic compounds
• A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Abstract

A dry powder inhalation treatment for pulmonary arterial hypertension includes a dose of dry particles comprising greater than 25 micrograms of treprostinil enclosed in a capsule. The dry particles can include treprostinil, a wetting agent, a hydrophobicity modifying agent, a pH modifying agent and a buffer. A method of treating a patient having pulmonary arterial hypertension includes providing a patient a dry powder inhaler, providing the patient at least one capsule for use in the dry powder inhaler, the capsule including at least 25 micrograms of treprostinil.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61P 9/12 - Antihypertensives
• A61K 31/557 - Eicosanoids, e.g. leukotrienes
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 31/5575 - Eicosanoids, e.g. leukotrienes having a cyclopentane ring, e.g. prostaglandin E2, prostaglandin F2-alpha
• A61K 47/02 - Inorganic compounds
• A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Goods & Services

Pharmaceutical preparations for inhalation for the treatment of pulmonary hypertension; pharmaceutical preparations for the treatment of pulmonary hypertension.

Abstract

A dry powder inhalation treatment for pulmonary arterial hypertension includes a dose of dry particles comprising greater than 25 micrograms of treprostinil enclosed in a capsule. The dry particles can include treprostinil, a wetting agent, a hydrophobicity modifying agent, a pH modifying agent and a buffer. A method of treating a patient having pulmonary arterial hypertension includes providing a patient a dry powder inhaler, providing the patient at least one capsule for use in the dry powder inhaler, the capsule including at least 25 micrograms of treprostinil.

IPC Classes  ?

• A61K 31/557 - Eicosanoids, e.g. leukotrienes
• A61P 9/12 - Antihypertensives
• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/48 - Preparations in capsules, e.g. of gelatin, of chocolate
• A61K 31/5575 - Eicosanoids, e.g. leukotrienes having a cyclopentane ring, e.g. prostaglandin E2, prostaglandin F2-alpha
• A61K 47/02 - Inorganic compounds
• A61K 47/18 - AminesAmidesUreasQuaternary ammonium compoundsAmino acidsOligopeptides having up to five amino acids
• A61K 47/26 - Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharidesDerivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Goods & Services

Pharmaceutical preparations for inhalation for the treatment of pulmonary hypertension; pharmaceutical preparations for the treatment of pulmonary hypertension

Goods & Services

Pharmaceutical preparations for inhalation for the treatment of pulmonary hypertension; pharmaceutical preparations for the treatment of pulmonary hypertension

Goods & Services

Pharmaceutical preparations for inhalation for the treatment of pulmonary hypertension; pharmaceutical preparations for the treatment of pulmonary hypertension

Abstract

A dry powder inhalation treatment for pulmonary arterial hypertension includes a dose of dry particles comprising greater than 25 micrograms of treprostinil enclosed in a capsule. The dry particles can include treprostinil, a wetting agent, a hydrophobicity modifying agent, a pH modifying agent and a buffer. A method of treating a patient having pulmonary arterial hypertension includes providing a patient a dry powder inhaler, providing the patient at least one capsule for use in the dry powder inhaler, the capsule including at least 25 micrograms of treprostinil.

IPC Classes  ?

• A61K 9/72 - Medicinal preparations characterised by special physical form for smoking or inhaling
• A61K 31/00 - Medicinal preparations containing organic active ingredients
• A61K 31/5575 - Eicosanoids, e.g. leukotrienes having a cyclopentane ring, e.g. prostaglandin E2, prostaglandin F2-alpha
• A61P 9/12 - Antihypertensives

Abstract

A dry powder inhalation treatment for pulmonary arterial hypertension includes a dose of dry particles comprising greater than 25 micrograms of treprostinil enclosed in a capsule. The dry particles can include treprostinil, a wetting agent, a hydrophobicity modifying agent, a pH modifying agent and a buffer. A method of treating a patient having pulmonary arterial hypertension includes providing a patient a dry powder inhaler, providing the patient at least one capsule for use in the dry powder inhaler, the capsule including at least 25 micrograms of treprostinil.

IPC Classes  ?

• A61P 9/12 - Antihypertensives
• A61K 9/72 - Medicinal preparations characterised by special physical form for smoking or inhaling
• A61K 31/00 - Medicinal preparations containing organic active ingredients
• A61K 31/192 - Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
• A61K 31/557 - Eicosanoids, e.g. leukotrienes
• A61P 9/00 - Drugs for disorders of the cardiovascular system

Abstract

A composition to induce analgesia includes a plurality of particles, each particle of the plurality having 40-60 wt% amino amide anesthetic or a pharmaceutically acceptable salt, hydrate, or solvate thereof and 60-40 wt% PLGA polymer including 48:52 to 52:48 molar ratio D,L lactide:glycolide and an inherent viscosity of about 0.16 to 0.24 dL/g at 0.1%w/v in chloroform at 25°C. Each particle includes a non-spherical shape less than 100 μιτι in a broadest dimension, and having a volume of about 13,500 cubic micrometers. The amino amide anesthetic is crystalline and includes 50-70% crystalline form I and 30-50% crystalline form II.

IPC Classes  ?

• A61K 31/167 - Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• A61K 9/10 - DispersionsEmulsions
• A61P 23/00 - Anaesthetics

Abstract

A laminate nanomold includes a layer of perfluoropolyether defining a cavity that has a predetermined shape and a support layer coupled with the layer of perfluoropolyether. The laminate can also include a tie-layer coupling the layer of perfluoropolyether with the support layer. The tie-layer can also include a photocurable component and a thermal curable component. The cavity can have a broadest dimension of less than 500 nanometers.

IPC Classes  ?

• B29C 33/60 - Releasing, lubricating or separating agents
• B29C 33/38 - Moulds or coresDetails thereof or accessories therefor characterised by the material or the manufacturing process
• B29C 33/40 - Plastics, e.g. foam or rubber
• B32B 3/30 - Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a particular shape of the outline of the cross-section of a continuous layerLayered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a layer with cavities or internal voids characterised by a layer formed with recesses or projections, e.g. grooved, ribbed
• B82Y 10/00 - Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
• B82Y 40/00 - Manufacture or treatment of nanostructures
• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor
• B29C 43/36 - Moulds for making articles of definite length, i.e. discrete articles
• B32B 37/18 - Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by the properties of the layers with all layers existing as coherent layers before laminating involving the assembly of discrete sheets or panels only
• B32B 38/00 - Ancillary operations in connection with laminating processes
• B29C 33/42 - Moulds or coresDetails thereof or accessories therefor characterised by the shape of the moulding surface, e.g. ribs or grooves
• B29C 43/22 - Compression moulding, i.e. applying external pressure to flow the moulding materialApparatus therefor of articles of indefinite length
• B29C 43/28 - Compression moulding, i.e. applying external pressure to flow the moulding materialApparatus therefor of articles of indefinite length incorporating preformed parts or layers, e.g. compression moulding around inserts or for coating articles
• B29L 31/00 - Other particular articles
• B29K 67/00 - Use of polyesters as moulding material
• B29K 71/00 - Use of polyethers as moulding material
• B29K 667/00 - Use of polyesters for preformed parts, e.g. for inserts

Abstract

The present invention concerns drug delivery particles which can prevent interaction between a biologically-active cargo comprised within the particles and components of an aqueous environment in which said particles are present. The particles are sensitive to p H such that above a threshold p H level the biologically-active cargo becomes accessible to the surrounding environment. Such particles are accordingly useful for stably storing a biologically-active cargo in an aqueous composition containing components which would otherwise interact deleteriously with the cargo, and releasing the cargo to mediate a biological effect in the body of an animal, such as a human, to which the composition is administered. Also provided are compositions comprising such particles, as well as methods for making and using such particles and compositions.

IPC Classes  ?

• A61K 39/102 - PasteurellaHaemophilus
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets

Abstract

Disclosed are inhalable antiviral pharmaceutical compositions of ribavirin, methods of producing the same, and the use of such compositions in the treatment of virally associated respiratory infections, and associated diseases and conditions.

IPC Classes  ?

• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/50 - Microcapsules
• A61K 31/7056 - Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom

Goods & Services

Custom manufacture of micro- and nano-particles, namely, those composed predominantly of polymers, for general scientific and research purposes and used in the manufacture of industrial goods; custom manufacture of micro- and nano- particles, namely, those composed predominantly of polymers or therapeutic or prophylactic or diagnostic agents used for medical purposes

Abstract

A laminate nanomold includes a layer of perfluoropolyether defining a cavity that has a predetermined shape and a support layer coupled with the layer of perfluoropolyether. The laminate can also include a tie-layer coupling the layer of perfluoropolyether with the support layer. The tie-layer can also include a photocurable component and a thermal curable component. The cavity can have a broadest dimension of less than 500 nanometers.

IPC Classes  ?

• B29C 33/60 - Releasing, lubricating or separating agents
• B29C 33/38 - Moulds or coresDetails thereof or accessories therefor characterised by the material or the manufacturing process
• B29C 33/40 - Plastics, e.g. foam or rubber
• B32B 3/30 - Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a particular shape of the outline of the cross-section of a continuous layerLayered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a layer with cavities or internal voids characterised by a layer formed with recesses or projections, e.g. grooved, ribbed
• B82Y 10/00 - Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
• B82Y 40/00 - Manufacture or treatment of nanostructures
• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor
• B29C 43/36 - Moulds for making articles of definite length, i.e. discrete articles
• B32B 37/18 - Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by the properties of the layers with all layers existing as coherent layers before laminating involving the assembly of discrete sheets or panels only
• B32B 38/00 - Ancillary operations in connection with laminating processes
• B29C 33/42 - Moulds or coresDetails thereof or accessories therefor characterised by the shape of the moulding surface, e.g. ribs or grooves
• B29C 43/22 - Compression moulding, i.e. applying external pressure to flow the moulding materialApparatus therefor of articles of indefinite length
• B29C 43/28 - Compression moulding, i.e. applying external pressure to flow the moulding materialApparatus therefor of articles of indefinite length incorporating preformed parts or layers, e.g. compression moulding around inserts or for coating articles
• B29L 31/00 - Other particular articles
• B29K 67/00 - Use of polyesters as moulding material
• B29K 71/00 - Use of polyethers as moulding material
• B29K 667/00 - Use of polyesters for preformed parts, e.g. for inserts

Abstract

A large area patterned film includes a first patterned area; a second patterned area; and a seam joining the first patterned area and the second patterned area, wherein the seam has a width less than about 20 micrometers. A method for tiling patterned areas includes depositing a predetermined thickness of a curable material; contacting a first portion of the curable material with a mold; curing the first portion of the curable material; removing the mold from the cured first portion of the curable material; contacting a second portion of the curable material with the mold, such that the mold contacts a portion of the cured first portion of the curable material; curing the second portion of the curable material; and removing the mold to yield a seam between the cured first portion of the curable material and the cured second portion of the curable material, wherein the seam has a dimension less than about 20 micrometers.

IPC Classes  ?

• B29C 59/02 - Surface shaping, e.g. embossingApparatus therefor by mechanical means, e.g. pressing
• B29C 35/08 - Heating or curing, e.g. crosslinking or vulcanising by wave energy or particle radiation
• B29C 43/00 - Compression moulding, i.e. applying external pressure to flow the moulding materialApparatus therefor
• B29C 43/02 - Compression moulding, i.e. applying external pressure to flow the moulding materialApparatus therefor of articles of definite length, i.e. discrete articles
• B82Y 10/00 - Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
• B82Y 40/00 - Manufacture or treatment of nanostructures
• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor
• B29C 43/14 - Compression moulding, i.e. applying external pressure to flow the moulding materialApparatus therefor of articles of definite length, i.e. discrete articles in several steps
• B29C 35/02 - Heating or curing, e.g. crosslinking or vulcanising
• B29C 37/00 - Component parts, details, accessories or auxiliary operations, not covered by group or
• B29C 43/06 - Compression moulding, i.e. applying external pressure to flow the moulding materialApparatus therefor of articles of definite length, i.e. discrete articles using movable moulds continuously movable
• B29K 105/00 - Condition, form or state of moulded material
• G02F 1/1333 - Constructional arrangements
• B29K 67/00 - Use of polyesters as moulding material
• B29L 9/00 - Layered products
• B29L 31/10 - Building elements, e.g. bricks, blocks, tiles, panels, posts, beams

Abstract

The disclosure relates to the field of pharmaceutical compositions, implants formed from pharmaceutical compositions, and methods of forming implants. More particularly, the present invention relates to delivering sustained release or depot delivery of radio-protector implants and methods for protecting tissues and glands from side effects of radiation treatment.

IPC Classes  ?

• A61K 31/485 - Morphinan derivatives, e.g. morphine, codeine

Abstract

A medical device includes a textured surface having a predetermined nanostructure, wherein the nanostructure is less than about 500 nanometers in a broadest dimension. The textures nanostructure surface reduces friction between the medical device and biological tissue.

IPC Classes  ?

• A61L 27/16 - Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
• H01L 29/06 - Semiconductor bodies characterised by the shapes, relative sizes, or dispositions of the semiconductor regions
• A61B 17/34 - TrocarsPuncturing needles
• A61F 2/00 - Filters implantable into blood vesselsProstheses, i.e. artificial substitutes or replacements for parts of the bodyAppliances for connecting them with the bodyDevices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
• A61L 27/50 - Materials characterised by their function or physical properties
• A61L 31/04 - Macromolecular materials
• A61L 31/14 - Materials characterised by their function or physical properties

Abstract

Virtual conjugate particles containing an active agent such as an antigenic polysaccharide or a nucleic acid with a charged biomolecule such as a protamine protein are described. The virtual conjugate particles typically contain a polymeric core particle that provides a surface for the association of the agent with a charged biomolecule. A cross-linker may be used to associate the agents with the core particle.

IPC Classes  ?

• A61K 9/14 - Particulate form, e.g. powders
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets
• A61K 39/385 - Haptens or antigens, bound to carriers

Abstract

A laminate nanomold includes a layer of perfluoropolyether defining a cavity that has a predetermined shape and a support layer coupled with the layer of perfluoropolyether. The laminate can also include a tie-layer coupling the layer of perfluoropolyether with the support layer. The tie-layer can also include a photocurable component and a thermal curable component. The cavity can have a broadest dimension of less than 500 nanometers.

IPC Classes  ?

• B29C 33/60 - Releasing, lubricating or separating agents
• B32B 38/00 - Ancillary operations in connection with laminating processes
• B29C 33/40 - Plastics, e.g. foam or rubber
• B32B 3/30 - Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a particular shape of the outline of the cross-section of a continuous layerLayered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a layer with cavities or internal voids characterised by a layer formed with recesses or projections, e.g. grooved, ribbed
• B82Y 10/00 - Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
• B82Y 40/00 - Manufacture or treatment of nanostructures
• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor
• B29C 43/36 - Moulds for making articles of definite length, i.e. discrete articles
• B29C 33/38 - Moulds or coresDetails thereof or accessories therefor characterised by the material or the manufacturing process
• B32B 37/18 - Methods or apparatus for laminating, e.g. by curing or by ultrasonic bonding characterised by the properties of the layers with all layers existing as coherent layers before laminating involving the assembly of discrete sheets or panels only
• B29L 31/00 - Other particular articles

Abstract

The present invention provides a system for fabricating a microneedle device and microneedle devices. The system includes depositing a first material on a delivery sheet, introducing the delivery sheet with deposited first material to a mold, passing the delivery sheet with deposited first material and mold through a nip-point to introduce at least a portion of first material into cavities in the mold, and separating the mold from the first material to provide a microneedle device with needles mimicking the cavities of the mold.

IPC Classes  ?

• A61M 37/00 - Other apparatus for introducing media into the bodyPercutany, i.e. introducing medicines into the body by diffusion through the skin
• A61M 5/158 - Needles

Abstract

A laminate nanomold includes a layer of perfluoropolyether defining a cavity that has a predetermined shape and a support layer coupled with the layer of perfluoropolyether. The laminate can also include a tie-layer coupling the layer of perfluoropolyether with the support layer. The tie-layer can also include a photocurable component and a thermal curable component. The cavity can have a broadest dimension of less than 500 nanometers.

IPC Classes  ?

• B29C 33/60 - Releasing, lubricating or separating agents
• B29C 33/38 - Moulds or coresDetails thereof or accessories therefor characterised by the material or the manufacturing process
• B29C 33/40 - Plastics, e.g. foam or rubber
• B32B 3/30 - Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a particular shape of the outline of the cross-section of a continuous layerLayered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form characterised by a layer with cavities or internal voids characterised by a layer formed with recesses or projections, e.g. grooved, ribbed
• B82Y 10/00 - Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
• B82Y 40/00 - Manufacture or treatment of nanostructures
• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor
• B29C 43/36 - Moulds for making articles of definite length, i.e. discrete articles
• B29L 31/00 - Other particular articles

Abstract

A system including a mold having a fluoropolymer wherein the mold defines a plurality of cavities having a predetermined shape and a cross-sectional dimension less than about 100 micrometers; a roller; a surface in cooperation with the roller to form a nip point configured to receive the mold, wherein the nip point is further configured to receive a substantially liquid composition and accelerate entry of the substantially liquid composition into the cavity. A method of forming particles including applying a substantially liquid composition to a mold, wherein the mold comprises a fluoropolymer and defines a plurality of cavities each having a broadest cross-sectional dimension of less than about 100 micrometers; nipping the mold between a roller and a surface such that the substantially liquid composition enters the cavities of the mold; and hardening the substantially liquid composition in the cavities of the mold to form a particle within each cavity, wherein the particle has a size and shape that substantially mimics the size and shape of the cavity of the mold.

IPC Classes  ?

• B29C 43/00 - Compression moulding, i.e. applying external pressure to flow the moulding materialApparatus therefor
• B29C 33/42 - Moulds or coresDetails thereof or accessories therefor characterised by the shape of the moulding surface, e.g. ribs or grooves
• B29L 31/00 - Other particular articles

Abstract

A large area patterned film includes a first patterned area; a second patterned area; and a seam joining the first patterned area and the second patterned area, wherein the seam has a width less than about 20 micrometers. A method for tiling patterned areas includes depositing a predetermined thickness of a curable material; contacting a first portion of the curable material with a mold; curing the first portion of the curable material; removing the mold from the cured first portion of the curable material; contacting a second portion of the curable material with the mold, such that the mold contacts a portion of the cured first portion of the curable material; curing the second portion of the curable material; and removing the mold to yield a seam between the cured first portion of the curable material and the cured second portion of the curable material, wherein the seam has a dimension less than about 20 micrometers.

IPC Classes  ?

• B29C 59/02 - Surface shaping, e.g. embossingApparatus therefor by mechanical means, e.g. pressing
• B29C 35/08 - Heating or curing, e.g. crosslinking or vulcanising by wave energy or particle radiation
• B29C 43/00 - Compression moulding, i.e. applying external pressure to flow the moulding materialApparatus therefor
• B29C 43/02 - Compression moulding, i.e. applying external pressure to flow the moulding materialApparatus therefor of articles of definite length, i.e. discrete articles
• B82Y 10/00 - Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
• B82Y 40/00 - Manufacture or treatment of nanostructures
• G03F 7/00 - Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printed surfacesMaterials therefor, e.g. comprising photoresistsApparatus specially adapted therefor
• B32B 27/00 - Layered products essentially comprising synthetic resin
• B29C 35/02 - Heating or curing, e.g. crosslinking or vulcanising
• B29C 37/00 - Component parts, details, accessories or auxiliary operations, not covered by group or
• B29C 43/06 - Compression moulding, i.e. applying external pressure to flow the moulding materialApparatus therefor of articles of definite length, i.e. discrete articles using movable moulds continuously movable
• B29C 43/14 - Compression moulding, i.e. applying external pressure to flow the moulding materialApparatus therefor of articles of definite length, i.e. discrete articles in several steps
• B29K 105/00 - Condition, form or state of moulded material
• G02F 1/1333 - Constructional arrangements

Abstract

A laminate nanomold includes a layer of perfluoropolyether defining a cavity that has a predetermined shape and a support layer coupled with the layer of perfluoropolyether. The laminate can also include a tie-layer coupling the layer of perfluoropolyether with the support layer. The tie-layer can also include a photocurable component and a thermal curable component. The cavity can have a broadest dimension of less than 500 nanometers.

IPC Classes  ?

• B29C 43/06 - Compression moulding, i.e. applying external pressure to flow the moulding materialApparatus therefor of articles of definite length, i.e. discrete articles using movable moulds continuously movable

Abstract

Disclosed herein are geometrically engineered particles having varied shapes and sizes and surface charge which can incorporate drugs and/or other biomaterials for targeted delivery, such as pulmonary delivery. The size, shape, etc. of a particle can be designed and corresponding particles can be prepared that target or de-target immunological responses to the particles themselves, for example, the response of alveolar macrophages. Methods of modulating immune responses by utilizing the particles are also disclosed. The particles can be composed substantially of therapeutic, drug and polymer or can comprise polymers and proteins. The particles may also be composed of diagnostic agents and additional biomaterials to confer aerosolization and cellular uptake properties. The particles also may have a range of physical features such as fenestrations, angled arms, asymmetry and surface roughness, charge which alter the interactions with cells and tissues.

IPC Classes  ?

• A61K 9/00 - Medicinal preparations characterised by special physical form
• A61K 9/16 - AgglomeratesGranulatesMicrobeadlets

Abstract

A laminate nanomold includes a layer of perfluoropolyether defining a cavity that has a predetermined shape and a support layer coupled with the layer of perfluoropolyether. The laminate can also include a tie-layer coupling the layer of perfluoropolyether with the support layer. The tie-layer can also include a photocurable component and a thermal curable component. The cavity can have a broadest dimension of less than 500 nanometers.

IPC Classes  ?

• B29C 43/06 - Compression moulding, i.e. applying external pressure to flow the moulding materialApparatus therefor of articles of definite length, i.e. discrete articles using movable moulds continuously movable

Abstract

A system including a mold having a fluoropolymer wherein the mold defines a plurality of cavities having a predetermined shape and a cross-sectional dimension less than about 100 micrometers; a roller; a surface in cooperation with the roller to form a nip point configured to receive the mold, wherein the nip point is further configured to receive a substantially liquid composition and accelerate entry of the substantially liquid composition into the cavity. A method of forming particles including applying a substantially liquid composition to a mold, wherein the mold comprises a fluoropolymer and defines a plurality of cavities each having a broadest cross-sectional dimension of less than about 100 micrometers; nipping the mold between a roller and a surface such that the substantially liquid composition enters the cavities of the mold; and hardening the substantially liquid composition in the cavities of the mold to form a particle within each cavity, wherein the particle has a size and shape that substantially mimics the size and shape of the cavity of the mold.

IPC Classes  ?

• B28B 7/34 - Moulds, cores, or mandrels of special material, e.g. destructible materials

Abstract

Particle compositions are prepared for use as polysaccharide particle vaccines.

IPC Classes  ?

• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

The present invention provides compounds that will degrade under specified conditions, methods of using such compounds, and compositions comprising such compounds. The degradable compounds of the invention may be characterized by the labile —Si-A-C— groups present in the compounds (A representing an atom, such as O, N, or S, or a group, such as C═O). The compounds may be incorporated into a composition that further may include a polymeric matrix and/or a cargo component. A wide variety of cargo components may also be used in the present invention. In particular embodiments, the cargo component comprises a drug or other therapeutic agent. Accordingly, the invention particularly provides pharmaceutical formulations and methods of delivering a drug or other therapeutic material.

IPC Classes  ?

• A61K 31/74 - Synthetic polymeric materials
• C07F 7/18 - Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages

Abstract

Particles that may be used for the fabrication of micro- and nanoarrays are provided. The particles may comprise one or more target molecules to be delivered to cavities on a substrate. Methods for preparing the particles and for introducing target molecules to the cavities using these particles to produce a micro- or nanoarray are also presented. Additionally, methods of using these micro- or nanoarrays are provided.

IPC Classes  ?

• C12Q 1/00 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions

Abstract

A polarizer including a substrate sheet configured with grid elements on at least a first surface, wherein the grid elements have a height to width aspect ratio of at least 1.5: 1, and metal coupled with the grid elements, wherein the metal comprises a height to width aspect ratio greater than the aspect ratio of the grid elements of the substrate.

IPC Classes  ?

• H01Q 15/24 - Polarising devicesPolarisation filters

Abstract

An engineered aerosol particle for use in aerosol applications is provided. The engineered aerosol particle comprises a fabricated nanoparticle body member being non- spherical. The fabricated nanoparticle body member is configured to provide at least one of auto-rotation, tumbling, or lift when entrained in an airstream to thereby increase settling time of the fabricated nanoparticle body member. An associated method is also provided.

IPC Classes  ?

• B01J 2/22 - Processes or devices for granulating materials, in generalRendering particulate materials free flowing in general, e.g. making them hydrophobic by pressing in moulds or between rollers

Abstract

A delivery system for local drug delivery to a target site of internal body tissue is provided. The delivery system comprises a source electrode adapted to be positioned proximate to a target site of internal body tissue. A counter electrode is in electrical communication with the source electrode, and is configured to cooperate with the source electrode to form a localized electric field proximate to the target site. A reservoir is configured to be disposed such that the reservoir is capable of interacting with the localized electric field. The reservoir is configured to carry a cargo capable of being delivered to the target site when exposed to the localized electric field. Associated methods are also provided.

IPC Classes  ?

• A61N 1/30 - Apparatus for iontophoresis or cataphoresis

Abstract

A large area patterned film includes a first patterned area; a second patterned area; and a seam joining the first patterned area and the second patterned area, wherein the seam has a width less than about 20 micrometers. A method for tiling patterned areas includes depositing a predetermined thickness of a curable material; contacting a first portion of the curable material with a mold; curing the first portion of the curable material; removing the mold from the cured first portion of the curable material; contacting a second portion of the curable material with the mold, such that the mold contacts a portion of the cured first portion of the curable material; curing the second portion of the curable material; and removing the mold to yield a seam between the cured first portion of the curable material and the cured second portion of the curable material, wherein the seam has a dimension less than about 20 micrometers.

IPC Classes  ?

• B27N 3/18 - Auxiliary operations, e.g. preheating, humidifying, cutting-off
• B29C 59/02 - Surface shaping, e.g. embossingApparatus therefor by mechanical means, e.g. pressing
• B29C 35/08 - Heating or curing, e.g. crosslinking or vulcanising by wave energy or particle radiation
• B32B 27/00 - Layered products essentially comprising synthetic resin
• B32B 3/00 - Layered products comprising a layer with external or internal discontinuities or unevennesses, or a layer of non-planar shapeLayered products comprising a layer having particular features of form
• B29C 65/00 - Joining of preformed partsApparatus therefor

Abstract

A large area patterned film includes a first patterned area; a second patterned area; and a seam joining the first patterned area and the second patterned area, wherein the seam has a width less than about 20 micrometers. A method for tiling patterned areas includes depositing a predetermined thickness of a curable material; contacting a first portion of the curable material with a mold; curing the first portion of the curable material; removing the mold from the cured first portion of the curable material; contacting a second portion of the curable material with the mold, such that the mold contacts a portion of the cured first portion of the curable material; curing the second portion of the curable material; and removing the mold to yield a seam between the cured first portion of the curable material and the cured second portion of the curable material, wherein the seam has a dimension less than about 20 micrometers.

IPC Classes  ?

• H01L 21/70 - Manufacture or treatment of devices consisting of a plurality of solid state components or integrated circuits formed in or on a common substrate or of specific parts thereofManufacture of integrated circuit devices or of specific parts thereof
• H01L 21/762 - Dielectric regions

Abstract

A membrane is provided, comprising a first membrane layer having a first side and a second side. The first membrane layer defines a plurality of holes extending along a first axis between the first side and the second side. Each hole is defined by the first membrane layer as a complex three-dimensional shape, and each hole has a diameter of less than about 10 micrometers. The membrane is fabricated by dispersing a liquid polymeric material onto a patterned master template, hardening the polymeric material, and removing it from the master template. The membrane includes through holes which correspond to the structures of the patterned master template in size, cross-sectional and three dimensional shape, orientation, and the like.

IPC Classes  ?

• B01D 67/00 - Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
• B01D 39/16 - Other self-supporting filtering material of organic material, e.g. synthetic fibres

Abstract

A nanoparticle is fabricated from a reaction of a polymer, a crosslinker, a nucleic acid, and between about 2 wt% and about 75 wt% of a charged monomer within a cavity of a mold resulting in a particle having a substantially predetermined three dimensional shape and a largest cross-sectional dimension of less than about 5 micron. The mold can include perfluoropoly ether and the nucleic acid can include less than about 30 nucleotides and the polymer can be poly( vinyl pyrrolidinone). The particles can be washed after being molded and the mold can include less than about 1 wt% initiator, less than about 0.5 wt% initiator, or less than about 0.1 wt% initiator.

IPC Classes  ?

• C08J 9/00 - Working-up of macromolecular substances to porous or cellular articles or materialsAfter-treatment thereof
• A61K 9/14 - Particulate form, e.g. powders

Abstract

The present invention provides compounds that will degrade under specified conditions, methods of using such compounds, and compositions comprising such compounds. The degradable compounds of the invention may be characterized by the labile -Si-A-C- groups present in the compounds (A representing an atom, such as O, N, or S, or a group, such as C=O). The compounds may be incorporated into a composition that further may include a polymeric matrix and/or a cargo component. A wide variety of cargo components may also be used in the present invention. In particular embodiments, the cargo component comprises a drug or other therapeutic agent. Accordingly, the invention particularly provides pharmaceutical formulations and methods of delivering a drug or other therapeutic material.

IPC Classes  ?

• A61K 31/00 - Medicinal preparations containing organic active ingredients
• C07F 7/08 - Compounds having one or more C—Si linkages
• B82B 1/00 - Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units

Abstract

A medical device includes a textured surface having a predetermined nanostructure, wherein the nanostructure is less than about 500 nanometers in a broadest dimension. The textures nanostructure surface reduces friction between the medical device and biological tissue.

IPC Classes  ?

• B29C 33/56 - CoatingsReleasing, lubricating or separating agents
• H01L 29/06 - Semiconductor bodies characterised by the shapes, relative sizes, or dispositions of the semiconductor regions

Abstract

A method of stimulating an immune response in a subject including administering a micrometer-sized particle coupled with an antigen to the subject, wherein increasing the aspect ratio of the micrometer-sized particle increases the immune response. A method of stimulating an immune response in a subject including administering to the subject a plurality of particles, wherein each particle is coupled with an immuno stimulating agent and a protein. A vaccine particle composition including a plurality of particles configured to release a first protein at a first rate and a second protein at a second rate and configured to provide priming and boosting capability in a single dose.

IPC Classes  ?

• A61K 9/14 - Particulate form, e.g. powders

Abstract

A delivery apparatus for delivering a cargo to a target site of internal body tissue is provided. The delivery apparatus comprises a flexible tubular member having a distal end adapted for insertion proximate to the target site. A first electrode is configured for insertion within the flexible tubular member such that the first electrode is capable of being disposed proximate to the target site. A second electrode is configured to cooperate with the first electrode to form an electric field. A delivery component has a cargo carried thereby and is coupled with the first electrode. The delivery component is configured to degrade when exposed to the electric field such that the cargo is released to the target site upon degradation thereof. An associated method is also provided.

IPC Classes  ?

• A61N 1/30 - Apparatus for iontophoresis or cataphoresis
• A61K 9/00 - Medicinal preparations characterised by special physical form

Abstract

A system including a mold having a fluoropolymer wherein the mold defines a plurality of cavities having a predetermined shape and a cross-sectional dimension less than about 100 micrometers; a roller; a surface in cooperation with the roller to form a nip point configured to receive the mold, wherein the nip point is further configured to receive a substantially liquid composition and accelerate entry of the substantially liquid composition into the cavity. A method of forming particles including applying a substantially liquid composition to a mold, wherein the mold comprises a fluoropolymer and defines a plurality of cavities each having a broadest cross-sectional dimension of less than about 100 micrometers; nipping the mold between a roller and a surface such that the substantially liquid composition enters the cavities of the mold; and hardening the substantially liquid composition in the cavities of the mold to form a particle within each cavity, wherein the particle has a size and shape that substantially mimics the size and shape of the cavity of the mold.

IPC Classes  ?

• B28B 5/00 - Producing shaped articles from the material in moulds or on moulding surfaces, carried or formed by, in or on conveyors irrespective of the manner of shaping
• B28B 3/12 - Producing shaped articles from the material by using pressesPresses specially adapted therefor wherein one or more rollers exert pressure on the material

Abstract

A mold having a fluoropolymer wherein the mold defines cavities having a shape and a cross-sectional dimension less than 100 micrometers, a roller, a surface in cooperation with the roller to form a nip point to receive the mold, wherein the nip point receives a liquid and accelerates entry of the liquid into the cavity Forming particles includes applying a liquid to a mold, wherein the mold comprises a fluoropolymer and defines a cavities each having a broadest crosssectional dimension of less than 100 micrometers, nipping the mold between a roller and a surface such that the liquid enters the cavities of the mold, and hardening the liquid in the cavities of the mold to form a particle within each cavity, wherein the particle has a size and shape that mimics the size and shape of th cavity of the mold

IPC Classes  ?

• B32B 5/16 - Layered products characterised by the non-homogeneity or physical structure of a layer characterised by features of a layer formed of particles, e.g. chips, chopped fibres, powder
• B28B 3/00 - Producing shaped articles from the material by using pressesPresses specially adapted therefor

Abstract

A laminate nanomold includes a layer of perfluoropolyether defining a cavity that has a predetermined shape and a support layer coupled with the layer of perfluoropolyether. The laminate can also include a tie-layer coupling the layer of perfluoropolyether with the support layer. The tie-layer can also include a photocurable component and a thermal curable component. The cavity can have a broadest dimension of less than 500 nanometers.

IPC Classes  ?

• B05D 3/12 - Pretreatment of surfaces to which liquids or other fluent materials are to be appliedAfter-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by mechanical means
• B32B 1/00 - Layered products having a non-planar shape

Abstract

A nanoarray includes a fluoropolymer array defining a plurality of cavities where each cavity has a predetermined shape and is less than about 5 micrometers in a broadest cross-sectional dimension. The nanoarray also includes a composition discretely contained in each cavity, where the composition includes a linking group for coupling with a modifying group. The nanoarray can be fabricated from fluoropolyether or perfluoropolyether.

IPC Classes  ?

• D04H 1/00 - Non-woven fabrics formed wholly or mainly of staple fibres or like relatively short fibres

Abstract

A polymer composite includes a polymer and an additive encased in the polymer, wherein the additive includes a plurality of isolated particles where each particle of the plurality of particles has a substantially predetermined three dimensional shape and is substantially oriented with respect to each other in a predetermined two dimensional array.

IPC Classes  ?

• B28B 1/00 - Producing shaped articles from the material

Abstract

A laminate nanomold includes a layer of perfluoropolyether defining a cavity that has a predetermined shape and a support layer coupled with the layer of perfluoropolyether. The laminate can also include a tie-layer coupling the layer of perfluoropolyether with the support layer. The tie-layer can also include a photocurable component and a thermal curable component. The cavity can have a broadest dimension of less than 500 nanometers.

IPC Classes  ?

• B29C 43/06 - Compression moulding, i.e. applying external pressure to flow the moulding materialApparatus therefor of articles of definite length, i.e. discrete articles using movable moulds continuously movable

Abstract

A plurality of nanoparticles, a structure assembled therefrom, a method of forming the structure, including a plurality of particles where each particle of the plurality of particles is configured with a substantially predetermined shape and a largest dimension less than about 100 micrometers, and where each particle of the plurality of particles includes an opening through the particle.

IPC Classes  ?

• B28B 1/00 - Producing shaped articles from the material
• B28B 3/00 - Producing shaped articles from the material by using pressesPresses specially adapted therefor

Abstract

Nanosized particles are molded from granules of organic substances in nano- scale molds. The nano-scale molds can be fabricated from non-wetting, low surface energy polymeric materials. The nanosized particles can be virtually any shape, are typically less than 500 micrometers in a broadest dimension, and can include pharmaceutical compositions, biologic drugs, drug compositions, organic materials, and the like.

IPC Classes  ?

• B02C 17/00 - Disintegrating by tumbling mills, i.e. mills having a container charged with the material to be disintegrated with or without special disintegrating members such as pebbles or balls
• A61K 9/14 - Particulate form, e.g. powders

Abstract

A photovoltaic device includes an encapsulation layer fabricated from an elastomeric material, such as for example a perfluoropolyether having favorable optical properties, gas permeable, scratch resistant, conformal liquid material. The encapsulation layer can also include a structured surface for manipulating and trapping light incident on the photovoltaic device.

IPC Classes  ?

• H01L 23/28 - Encapsulation, e.g. encapsulating layers, coatings
• H01L 23/29 - Encapsulation, e.g. encapsulating layers, coatings characterised by the material
• H01L 23/31 - Encapsulation, e.g. encapsulating layers, coatings characterised by the arrangement

Goods & Services

Micro- and nano-particles, namely, those composed of polymers, used for general scientific and research purposes; micro- and nano-particles, namely, those composed predominantly of polymers, used in the manufacture of industrial goods; micro- and nano-particles, namely, those composed predominantly of polymers modified with an encapsulated or surface-coated substance that provides identification, used in industrial goods Micro- and nano-particles, namely, those composed of polymers, therapeutics or excipients used for medical diagnostic and treatment purposes Custom manufacture of micro- and nano-particles, namely, those composed predominantly of polymers, for general scientific and research purposes and used in the manufacture of industrial goods; custom manufacture of micro- and nano-particles, namely, those composed predominantly of polymers or therapeutics used for medical purposes

Goods & Services

Micro- and nano-particles, namely, those composed predominantly of polymers, therapeutics or excipients used for medical diagnostic and treatment purposes

Goods & Services

[ Micro- and nano-particles, namely, those composed of polymers, used for general scientific and research purposes; micro- and nano-particles, namely, those composed predominantly of polymers, used in the manufacture of industrial goods other than those used for printing purposes ] Custom manufacture of micro- and nano-particles, namely, those composed predominantly of polymers, for general scientific and research purposes and used in the manufacture of industrial goods other than those used for printing purposes; custom manufacture of mico- and nano-particles, namely, those composed predominantly of polymers or therapeutics used for medical purposes