37 - Construction and mining; installation and repair services
42 - Scientific, technological and industrial services, research and design
Goods & Services
Installation, maintenance and repair of surgical and medical apparatus, devices and instruments Design and development of computer hardware and software for use in the medical field; Medical research in the fields of cardiopulmonary and cardiac surgery, neuromodulation, epilepsy, advanced circulatory support, depression, and sleep disorders; Non-downloadable computer software; Providing an internet website portal featuring information on implantable pulse generators used for the treatment of medical conditions; Providing an internet website portal featuring information on extracorporeal circulation during cardiac surgery operations; Scientific and technological services in the field of medical implants and associated therapies, and research and design relating thereto; Scientific research and development in the medical and surgical fields
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
37 - Construction and mining; installation and repair services
42 - Scientific, technological and industrial services, research and design
Goods & Services
Apparatus and instruments for conducting, switching, transforming, accumulating, regulating or controlling the distribution or use of electricity; Apparatus for recording, transmission or reproduction of sound or images; Battery modules, power supply units, monitors, display, mixing, measuring, control and/or regulating apparatus, in particular for equipment and apparatus for medical and surgical purposes; Data processing apparatus; Downloadable computer software; Devices and instruments for monitoring, regulating and controlling gas flow, including electronic consoles; Disposable integrated system heart lung machine for extracorporeal circulation; Downloadable scientific and medical data via the internet; Downloadable instruction manuals in the fields of cardiopulmonary and cardiac surgery, neuromodulation, and advanced circulatory support; Handheld remote control units for controlling an implantable pulse generator; Research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids Arrhythmia and transfusion devices; monitors; filters; blood transfusion systems/fittings; body rehabilitation apparatus; brackets, auxiliary masts, rack housings being parts; cannulae; carbon dioxide removal systems; cardiopulmonary bypass (CBP) machines; blood pumps; circulatory assist devices; systems and components that monitor and sense body data streams; oxygenators; suction instruments; pulse generators; electrodes; catheters; monitoring systems; extracorporeal apparatus/devices; programmers; valves; ventricular assist devices; implantable medical devices; measuring apparatus/equipment; regulators; tubes; medical apparatus and instruments for use in surgery; medical devices, systems and instruments; implants; guide wires; membranes; medical leads; neurostimulators; patient kits; tubing systems; assist devices; portable medical systems; telemetry wands; tunnelers; flow measurement systems; nerve stimulators; vascular devices and repairing parts; mixing, control and/or regulating equipment for medical machines; parts/replacement parts for all of the foregoing Installation, maintenance and repair of surgical and medical apparatus, devices and instruments Design and development of computer hardware and software for use in the medical field; Medical research in the fields of cardiopulmonary and cardiac surgery, neuromodulation, epilepsy, advanced circulatory support, depression, and sleep disorders; Non-downloadable computer software; Providing an internet website portal featuring information on implantable pulse generators used for the treatment of medical conditions; Providing an internet website portal featuring information on extracorporeal circulation during cardiac surgery operations; Scientific and technological services in the field of medical implants and associated therapies, and research and design relating thereto; Scientific research and development in the medical and surgical fields
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
37 - Construction and mining; installation and repair services
42 - Scientific, technological and industrial services, research and design
Goods & Services
Apparatus and instruments for conducting, switching, transforming, accumulating, regulating or controlling the distribution or use of electricity; Apparatus for recording, transmission or reproduction of sound or images; Battery modules, power supply units, monitors, display, mixing, measuring, control and/or regulating apparatus, in particular for equipment and apparatus for medical and surgical purposes; Data processing apparatus; Downloadable computer software; Devices and instruments for monitoring, regulating and controlling gas flow, including electronic consoles; Disposable integrated system heart lung machine for extracorporeal circulation; Downloadable scientific and medical data via the internet; Downloadable instruction manuals in the fields of cardiopulmonary and cardiac surgery, neuromodulation, and advanced circulatory support; Handheld remote control units for controlling an implantable pulse generator; Research laboratory analyzers for measuring, testing and analyzing blood and other bodily fluids Arrhythmia and transfusion devices; monitors; filters; blood transfusion systems/fittings; body rehabilitation apparatus; brackets, auxiliary masts, rack housings being parts; cannulae; carbon dioxide removal systems; cardiopulmonary bypass (CBP) machines; blood pumps; circulatory assist devices; systems and components that monitor and sense body data streams; oxygenators; suction instruments; pulse generators; electrodes; catheters; monitoring systems; extracorporeal apparatus/devices; programmers; valves; ventricular assist devices; implantable medical devices; measuring apparatus/equipment; regulators; tubes; medical apparatus and instruments for use in surgery; medical devices, systems and instruments; implants; guide wires; membranes; medical leads; neurostimulators; patient kits; tubing systems; assist devices; portable medical systems; telemetry wands; tunnelers; flow measurement systems; nerve stimulators; vascular devices and repairing parts; mixing, control and/or regulating equipment for medical machines; parts/replacement parts for all of the foregoing Installation, maintenance and repair of surgical and medical apparatus, devices and instruments Design and development of computer hardware and software for use in the medical field; Medical research in the fields of cardiopulmonary and cardiac surgery, neuromodulation, epilepsy, advanced circulatory support, depression, and sleep disorders; Non-downloadable computer software; Providing an internet website portal featuring information on implantable pulse generators used for the treatment of medical conditions; Providing an internet website portal featuring information on extracorporeal circulation during cardiac surgery operations; Scientific and technological services in the field of medical implants and associated therapies, and research and design relating thereto; Scientific research and development in the medical and surgical fields
4.
PRIMING SYSTEM FOR USE WITH A MEDICAL FLUID SYSTEM
A system for priming a fluid system includes a fluid connector configured to interface with a fluid source and a fluid reservoir including a first connector configured to couple with an inflow line of the fluid system, a second connector configured to couple with an outflow line of the fluid system, and a gas release valve. A system for priming a fluid system includes first and second fluid connectors configured to interface with a fluid source, a first connector configured to couple with an inflow line of the fluid system, a second connector configured to couple with an outflow line of the fluid system, and a gas release valve. A method of priming the fluid system includes coupling the first connector with the inflow line, coupling the second connector with the outflow line, coupling the first fluid connector with the fluid source, and elevating the fluid source.
A61M 60/113 - Extracorporeal pumps, i.e. the blood being pumped outside the patient’s body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
A blood oxygenator includes a housing having a first end opposite a second end with a sidewall extending between the first end and the second end along a longitudinal axis. The housing defines an interior chamber having a liquid inlet at the first end and a liquid outlet at the second end. The oxygenator further includes a gas exchange assembly positioned within the interior chamber. The gas exchange assembly includes a retainer having an upper cap spaced apart from a lower cap by one or more spacers, and a gas exchange medium disposed between the upper cap and the lower cap. The gas exchange medium has a plurality of subunits stacked on top of each other, with each subunit having a plurality of layers of hollow fiber mats.
Prosthetic heart valves described herein can be deployed using a transcatheter delivery system and technique to interface and anchor in cooperation with the anatomical structures of a native heart valve. Some embodiments of prosthetic mitral valves described herein include an anchor portion that couples the prosthetic mitral valve to the anatomy near the native mitral valve, and a valve portion that is mateable with the anchor portion. Some embodiments of the transcatheter delivery system can include systems and techniques for retrieval of the anchor portions and the valve portion.
The present invention relates to a coupling device and placement method for connecting a syringe to a proximal connector (e.g., hub) of a catheter to allow injection of a liquid (e.g., a contract agent) and rotation of the catheter by the syringe. The coupling device is configured to allow fixation of the syringe at the proximal end of the catheter in the axis of rotation of the catheter and comprises an insertion portion for inserting of a medical device/instrument into the catheter and an outlet portion for guiding a liquid tube from an ejection outlet of the syringe to the proximal connector of the catheter.
The invention relates to a conical fixation helix and a capsule (e.g., a leadless pacing, sensing and/or communicating device) that comprises the conical fixation helix for fixing the pacing device at a patient's tissue. The conical shape of the fixation helix provides better attachment of the pacing device to the patient's tissue and compression of the patient's tissue towards a tip electrode of the capsule.
The invention relates to a a multi-level tip electrode and a pacing device (e.g., a leadless or lead device) that comprises the multi-level tip electrode and a fixation helix for fixing the pacing device at a patient's tissue. A multi-level shape of the tip electrode in the axial/longitudinal direction of the pacing device stabilizes the attachment to the patient's tissue and improves electrical connection by offering more effective surface area.
The present invention relates to a locking device and method for a two-step locking operation, wherein a distal fixation helix of a lead device is first extended by inserting a rotatable connector pin of a proximal connector of the lead device into a first cavity of a first portion of the locking device and applying a moderate (over-)torque to the connector pin by means of the locking device. Then, a very simple locking gesture (e.g., a sliding or pressing gesture) is applied to lock a rotationally coupled second portion of the locking device to the connector body in a second cavity of the second portion of the lock- ing device without any release of the moderated torque initially applied to the connector pin. This allows a physician or other user to apply and maintain a moderate (over-)torque at the connector pin after helix extension while turning/rotating the lead body via the connector end during a puncturing operation.
A bi-directional perfusion cannula is provided that includes an elongate tube for insertion into an artery. The elongate tube has a first aperture at a distal end of the tube which is forward during insertion and configured so that blood can flow into the artery in the direction of insertion, an elbow formed in the elongate tube, and a second aperture formed in or slightly rearward of the elbow and configured for supplying blood into the artery in a second direction which is generally opposite to the insertion direction.
A syringe for de-airing a liquid conduit of an extracorporeal life support system includes an inner barrel having an elongated distal tip defining a distal tip opening, and a proximal open end, and an outer barrel at least partially surrounding the inner barrel. An inner wall of the outer barrel is spaced apart from at least a portion of an outer wall of the inner barrel defining a space therebetween. The outer barrel has a distal end with at least one opening proximal of the distal tip opening of the inner barrel, and a proximal opening such that the space is open to the ambient environment via the proximal opening. The syringe also includes a plunger disposed within and sealing the proximal open end of the inner barrel with a friction fit with an inner wall of the inner barrel.
09 - Scientific and electric apparatus and instruments
10 - Medical apparatus and instruments
Goods & Services
Downloadable application software for smartphones and mobile devices, namely, software for tracking and maintaining health and treatment plans related to sleep disorders; Downloadable software for facilitating communication and collaboration for medical treatment related to sleep disorders between medical facilities, clinicians, caregivers, and patients; Downloadable software for providing health, wellness, healthcare, patient care, virtual education, and medical information related sleep disorders; Downloadable patient and clinician computer programs used in programming, monitoring, and controlling an implantable pulse generator; Downloadable software in the nature of patient management and support software for receiving, storing, tracking, managing, and analyzing patient medical information related to sleep disorders; Handheld remote control units for controlling an implantable pulse generator Implantable medical devices for neuro stimulation incorporating recorded operating system software for use in sleep therapy; Structural parts, controllers and fittings for implantable medical devices for neuro stimulation used in sleep therapy
Prosthetic heart valves described herein can be deployed using a transcatheter delivery system and technique to interface and anchor in cooperation with the anatomical structures of a native heart valve. Deployment systems and methods for using the deployment systems described herein facilitate accurately and conveniently controllable percutaneous, transcatheter techniques by which the prosthetic heart valves can be delivered and deployed within a patient.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61F 2/95 - Instruments specially adapted for placement or removal of stents or stent-grafts
A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters
15.
OXYGENATOR WITH CIRCUMFERENTIALLY CONSTRICTING HOUSING
An oxygenator may include a housing extending from a first end to a second end, and a bundle of hollow gas exchange fibers extending between the first end and the second end. At least a portion of the housing may be configured to selectively move radially with respect to the bundle of hollow gas exchange fibers. An oxygenator may include a rigid housing extending from a first end to a second end, a flexible housing disposed within the rigid housing, and a bundle of hollow gas exchange fibers extending between the first end and the second end within the flexible housing. At least a portion of the flexible housing may be configured to selectively move radially with respect to the bundle of hollow gas exchange fibers.
An oxygenator may include a housing extending from a first end to a second end along a central longitudinal axis, a first end cap, a second end cap, and a bundle of hollow gas exchange fibers extending between the first end and the second end. The first end cap and the second end cap may each be rotatable about the central longitudinal axis. An oxygenator may include a bundle of hollow gas exchange fibers extending from the first end cap to the second end cap. An oxygenator may include a housing including a first axially expandable portion, a second axially expandable portion, and a rigid tubular portion disposed between and fixedly attached to the first and second axially expandable portions. An oxygenator may include a bundle of hollow gas exchange fibers may be axially movable relative to the housing.
This invention relates to a method and system for determining and/or tracking a heart function of a patient. wherein the heart function is estimated by combining information representative of an electrical, mechanical and/or hemodynamic heart function received from imaging, therapy and/or diagnosis systems or a patient database with real-time information representative of an electrical, mechanical and/or hemodynamic heart function received from a measuring device attached or implanted to the patient. The information and the real-time information from can be associated to update an evaluation of the heart function of the patient in real-time and thereby improve the heart function and possibly optimize its efficiency.
A61M 60/178 - Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient’s body implantable in, on, or around the heart drawing blood from a ventricle and returning the blood to the arterial system via a cannula external to the ventricle, e.g. left or right ventricular assist devices
A61M 60/196 - Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient’s body replacing the entire heart, e.g. total artificial hearts [TAH]
A61M 60/216 - Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
A61M 60/403 - Details relating to driving for non-positive displacement blood pumps
A61M 60/515 - Regulation using real-time patient data
A61N 1/365 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential
Described is a gas exchanger with a restriction element or elements to reduce gas exchange as desired to avoid hypo-capnia and hyper-oxygenation in small patients. The gas exchanger includes a gas exchanger housing with an outer wall and a core which defines an inner wall and having a blood inlet for receiving a blood supply and a blood outlet. The gas exchanger also includes: a hollow fiber bundle disposed within the housing between the core and the outer wall; and a gas inlet compartment for receiving an oxygen supply and directing the oxygen supply to first ends of the hollow fiber bundle, wherein the gas inlet compartment includes at least one restriction element configured to allow the oxygen supply to reach only a portion of the hollow fiber bundle.
An adaptor for use in a blood conduit of an extracorporeal life support system. The adaptor includes a body defining a main passageway and an auxiliary port extending from the body with a passageway of the auxiliary port converging with the main passageway. The auxiliary port includes a hemostasis valve configured to selectively seal around a medical device inserted through the auxiliary port into the main passageway. An elastomeric valve may be positioned in the passageway of the auxiliary port spaced away from the hemostasis valve such that elastomeric valve is located between the hemostasis valve and the main passageway. In some instances, the hemostasis valve may be removably couplable to the auxiliary port.
A61M 60/113 - Extracorporeal pumps, i.e. the blood being pumped outside the patient’s body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
An apparatus includes a blood-flow-management assembly shaped to define a cylindrical aperture. The blood-flow-management assembly includes a blood collector having drainage holes configured to direct blood to a guide surface positioned below the blood collector. The guide surface may further include ribs that manage blood flow along the guide surface.
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
A61M 60/113 - Extracorporeal pumps, i.e. the blood being pumped outside the patient’s body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
The invention relates to a pacing device (e.g., leadless capsule) that comprises a distal fixation helix for fixing the pacing device at a patient's tissue, wherein the fixation helix comprises an expandable portion that extends when the fixation helix is screwed into the tissue, to thereby reduce the space required during insertion and allow a placement of the pacing device in a bent state for minimal unwanted mechanical interaction.
The invention relates to a lead device with improved puncturing capability and reliability. The proposed structure, shape and dimensions of a tip of the lead device are configured to enable a controlled and smooth puncturing process through the septum or other tissue at the target area with high reliability and longevity. A fixed helix is provided to facilitate handling and an additional screwing sty let with screwdriver functionality may be provided to improve torque transfer to the tip of the lead device for better control of a puncturing process.
The present invention relates to a fixation tool for clamping and rotating a lead terminal pin of a medical implantable cardiac lead. The fixation tool comprises a handle portion and a jaw portion, wherein opposing inner surfaces of a pair of jaws of the jaw portion are shaped to form a cavity system between the pair of jaws, the cavity system comprising a first cavity located proximal to an opening at the distal end of the jaw portion and having a first width between the opposing inner surfaces and being shaped to clamp a first lead terminal pin of a first diameter, and a second cavity located proximal to the first cavity and having a second width between the opposing inner surfaces, smaller than the first width and adapted to clamp, together with the first cavity, a second lead terminal pin of a second diameter larger than the first diameter.
A system includes a cuvette including a cuvette body forming a substantially planar exterior surface and having a sensor window defined within the substantially planar exterior surface. The cuvette further includes a probe retention structure extending from the cuvette body. The system includes a probe with a probe body and a protrusion that is removably coupled to the probe retention structure.
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
The invention relates to a multi-electrode lead device that comprises an interelectrode portion between a distal first electrode and a proximal second electrode, wherein the interelectrode portion comprises an elongated surface electrode for right bundle branch pacing, the elongated surface electrode having a reduced exposed area and at least one non-exposed portion to obtain an increased current density, wherein the elongated surface electrode is connected to a single pacing input terminal of a proximal lead connector. The elongated surface electrode with reduced exposed area enables lower energy consumption by achieving the increased current density and provides an enhanced right bundle branch pacing area for various anatomies.
The invention relates to a multi-electrode lead device that comprises an interelectrode portion between a distal first electrode and a proximal second electrode, wherein the interelectrode portion comprises two or more additional surface electrodes ("directional" surface electrodes) having a reduced circumferential width for directional pacing and arranged in an axial sequence to obtain an elongated right bundle branch pacing area. Therefore, there is no need for multiple lead models for different anatomies and/or pre- operation examination to measure the septum wall thickness. Moreover, the pacing direction and thus the pacing efficiency of the additional directional surface electrodes can be optimized/adjusted by rotating the lead device around its longitudinal axis.
The invention relates to a lead device that comprises a lead tip with a distal fixation helix for fixing the lead tip at a patient's tissue (e.g., cardiac tissue, in particular tissue of the septum) wherein the fixation helix comprises a cutting portion for cutting the tissue in a circumferential direction of the fixation helix, in addition to a puncturing by a distal tip of the fixation helix (30), when the fixation helix is screwed into the tissue, to support longitudinal insertion of the lead tip with the fixation helix into the tissue. Thereby, insertion and longitudinal advancement of the lead tip into the tissue can be facilitated and smoothened due to a pre-cutting of the tissue in a circumferential direction at and/or around and/or within the fixation helix during the screwing operation into the tissue.
A dual lumen coaxial cannula assembly includes a first infusion tube having a first elongate body defining a first lumen therethrough and a second drainage tube co-axially aligned with the first infusion tube and having a second elongate body with a second lumen defined by a space between the first infusion tube and second drainage tube. A connector is removably attached to the first infusion tube and the second drainage tube for coupling the dual lumen coaxial cannula to an extracorporeal blood circuit. The first infusion tube and the second drainage tube include a plurality of infusion and drainage apertures, respectively, provided at the distal end and extending through the sidewall of the first infusion tube and the drainage tube, respectively.
A61M 60/113 - Extracorporeal pumps, i.e. the blood being pumped outside the patient’s body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
A61M 60/13 - Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient’s body implantable via, into, inside, in line, branching on, or around a blood vessel by means of a catheter allowing explantation, e.g. catheter pumps temporarily introduced via the vascular system
A61M 60/165 - Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient’s body implantable in, on, or around the heart
A cannula includes a tube having a proximal end, a distal end, and a tubular sidewall extending between the proximal end and the distal end. The cannula further includes an extendable member provided on a portion of the sidewall. The extendable member is configured to extend radially outward from the sidewall. The sidewall defines an aperture located between the proximal end and the distal end of the main tube.
Described is a blood processing apparatus with a blood flow path and a heat exchanger fluid flow path overlapping the a heat exchanger chamber, in which the blood flows generally from a first end to a second end of the blood processing apparatus, and the heat exchanger fluid flows generally from the second end to the first end. Such “counter” or “countercurrent” flow improves heat transfer between the blood and the heat exchanger fluid. The blood processing apparatus includes a housing, a blood inlet, a heat exchanger fluid inlet and a heat exchanger fluid outlet, a heat exchanger core, a cylindrical shell having an annular shell aperture, a blood flow distributor, and a central chamber in fluid communication to a fluid flow distributor.
The present invention relates to a fixation tool for clamping and rotating a lead terminal pin of a medical implantable cardiac lead. The fixation tool comprises a handle portion and a jaw portion, wherein opposing inner surfaces of a pair of jaws of the jaw portion are shaped to form a cavity system between the pair of jaws, the cavity system comprising a first cavity located proximal to an opening at the distal end of the jaw portion and having a first width between the opposing inner surfaces and being shaped to clamp a first lead terminal pin of a first diameter, and a second cavity located proximal to the first cavity and having a second width between the opposing inner surfaces, smaller than the first width and adapted to clamp, together with the first cavity, a second lead terminal pin of a second diameter larger than the first diameter.
An autotransfusion system for separating fluid constituents includes a centrifuge housing and a rotatable driving member mounted within the centrifuge housing. The rotatable driving member is configured to receive therein and rotationally engage any one of a plurality of centrifuge bowls with different heights. In some embodiments, the centrifuge bowl is integrated with a fluid line organizer to provide for easy and efficient organization of a plurality of different fluid lines incorporated into the autotransfusion system. In some embodiments, the centrifuge bowl and fluid line organizer are easily and efficiently coupled to the centrifuge housing for autotransfusion processing. After autotransfusion processing, the centrifuge bowl and fluid line organizer are easily and efficiently decoupled from the centrifuge housing and discarded.
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (France)
ASSISTANCE PUBLIQUE- HOPITAUX DE PARIS (France)
Inventor
Migliazza, John F.
Spiritelli, Sandra
Scatton, Olivier
Savier, Eric
Goumard, Claire
Abstract
An organ perfusion and preservation system for use in preserving an organ from a donor, may include a fluid reservoir, a heat exchanger in fluid communication with the fluid reservoir and configured to selectively raise and lower a temperature of a perfusion fluid, an oxygenator configured to oxygenate the perfusion fluid, an inflow pump in fluid communication with the fluid reservoir and the oxygenator, a fluid inflow line configured to transport perfusion fluid from the oxygenator to the organ, a fluid outflow line configured to transport perfusion fluid away from the organ and back to the reservoir, an outflow pump in fluid communication with the fluid outflow line and the fluid reservoir, and a controller operatively connected to the inflow pump, the outflow pump, and the heat exchanger, wherein the controller is configured to select parameters to reversibly heat and reversibly cool the organ.
System for characterizing a cardiac rhythm, configured to implement, by computer, the following steps: ■ generating an input vector, the components of the input vector comprising, among indicators of sets of indicators of probability of presence only each indicator of probability of presence of a selection, ■ generating, using a global classifier, global indicators of probability of presence of arrhythmias in a time window from the input vector, the system comprising a selector making it possible to select and/or deselect at least one of the indicators of probability of presence such that the selection is composed of each indicator of probability of presence selected.
122) of the probability of the presence of the arrhythmia in the time window by using a classifier using values of the set of at least one derivation, - generating indicators of the probability of the presence of the arrhythmia in the time window by using a second classifier using first portions including a portion preceding the R-wave, combinations of second beat portions of the set of at least one derivation, - generating indicators of the probability of the presence of the arrhythmia in the time window by using a classifier using a set of statistical indicators representative of the distribution of R-R intervals.
The invention relates to a lead device with improved puncturing capability and reliability. The proposed structure, shape and dimensions of a tip of the lead device are configured to enable a controlled and smooth puncturing process through the septum or other tissue at the target area with high reliability and longevity. A fixed helix is provided to facilitate handling and an additional screwing stylet with screwdriver functionality may be provided to improve torque transfer to the tip of the lead device for better control of a puncturing process.
The invention relates to a screwing stylet for improving torque transfer from a physician's hand to a lead tip (e.g., helix) of a lead device. A lead tip is provided to facilitate handling and a screwdriver functionality of the screwing stylet is provided to improve torque transfer to the lead tip of the lead device for better control of a puncturing process. The screwing stylet can be engaged directly with the tip of the lead device, thereby allowing a direct and efficient torque transfer to the fixed helix at the tip.
The present invention relates to a step-up converter with a plurality of levels, in particular for use in an implantable medical device, comprising a transformer (11) comprising a single primary winding and a single secondary winding; a primary circuit (6) comprising the single primary winding; and a secondary circuit (7) comprising the single secondary winding and a plurality of step-up levels, each of the step-up levels comprising a first diode (4a, 4b, 4c, 4d, 4e, 4f) and a second diode (10a, 10b, 10c, 10d, 10e, 10f) and a first capacitor (9a, 9b, 9c, 9d, 9e, 9f) and a second capacitor (3a, 3b, 3c, 3d, 3e, 3f), wherein the first capacitors (9a, 9b, 9c, 9d, 9e, 9f) of the plurality of step-up levels are connected in series or in parallel with one another. The present invention also relates to an implantable medical device comprising the step-up converter with a plurality of levels mentioned above, and a method for using the step-up converter with a plurality of levels or the implantable device mentioned above.
H02M 3/00 - Conversion of DC power input into DC power output
H02M 3/335 - Conversion of DC power input into DC power output with intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate AC using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only
39.
DUAL LUMEN CANNULA WITH ADJUSTABLE LENGTH INFUSION TUBE
A dual lumen coaxial cannula assembly including a first infusion tube having a proximal end, a distal end, and a sidewall extending circumferentially therebetween, as well as a second drainage tube co-axially aligned with the first infusion tube, the second drainage tube having a proximal end, a distal end, and a sidewall extending circumferentially therebetween. The assembly also includes a connector assembly, which has an inlet portion through which a portion of the first infusion tube is configured to extend and an outlet portion through which a portion of the second drainage tube is configured to extend. The connector assembly is configured to enable selective axial displacement of the first infusion tube through the second drainage tube.
A cannula for an ECLS system may include a tubular member and an actuatable structure. The actuatable structure may be responsive to an external stimulus such that an inner diameter of the tubular member changes as the external stimulus changes. A system may include the cannula and a controller in electrical communication with the actuatable structure. The controller may be user-configurable to set a desired value for an inner diameter of the tubular member. A method of connecting a patient's vasculature to an ECLS system may include advancing a delivery sheath into the vasculature, moving the delivery sheath relative to the cannula to expose the cannula within the vasculature, and shifting the actuatable structure from a first configuration to a second configuration while at least a portion of the cannula is disposed within the vasculature to change an inner diameter of the tubular member.
A61M 60/845 - Constructional details other than related to driving of extracorporeal blood pumps
A61M 60/117 - Extracorporeal pumps, i.e. the blood being pumped outside the patient’s body for assisting the heart, e.g. transcutaneous or external ventricular assist devices
41.
EXTRACORPOREAL LIFE SUPPORT SYSTEM WITH BLOOD RECIRCULATION PATHWAY
An extracorporeal blood treatment system including a blood oxygenator having an inlet for receiving deoxygenated blood and an outlet for expelling oxygenated blood. The system also includes a recirculation flow path for recirculating a portion of the oxygenated blood exiting the oxygenator outlet back into the oxygenator inlet. The system may also include a dual-lumen cannula coupled to the oxygenator. The cannula includes a manifold with a first blood pathway communicating with the oxygenator outlet, a second blood pathway communicating with the oxygenator inlet, and a third blood pathway connecting the first blood pathway to the second blood pathway. The manifold passes oxygenated blood received from the oxygenator through the first blood pathway, passes deoxygenated blood received from the patient through the second blood pathway, and passes a portion of the oxygenated blood from the first blood pathway through the third blood pathway to be combined with deoxygenated blood in the second blood pathway.
A system for assisting a patient's heart has a pump, an oxygenator, a holder having a pump receiving portion for removably receiving the pump and an oxygenator receiving portion for removably receiving the oxygenator, and a harness configured to surround at least a portion of a patient's torso. The holder is connected to the harness. The system further has a brace connected to at least a portion of the harness. The brace is configured to extend behind a back portion of a user's head and to support tubing connected to at least one of the pump and the oxygenator. A priming tray and wet-to-wet connector connecting the cardiac assist system to the cannula so are also disclosed.
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
A61M 60/113 - Extracorporeal pumps, i.e. the blood being pumped outside the patient’s body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
A61M 60/117 - Extracorporeal pumps, i.e. the blood being pumped outside the patient’s body for assisting the heart, e.g. transcutaneous or external ventricular assist devices
A61M 60/216 - Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
A device for monitoring operation of a probe of an implantable active cardiac device, in particular an implantable automatic defibrillator or a defibrillator for cardiac resynchronization. The device comprising a parameter-determining device for determining values of a plurality of parameters characterizing the probe, and a processing unit configured to determine representative values that are representative of at least one parameter of the plurality of parameters characterizing the probe based on at least two different time scales. The processing unit is further configured to compare an analysis value of the at least one parameter of the plurality of parameters characterizing the probe with the representative values of the at least one parameter.
A centrifugal blood pump includes a housing having a pumping chamber, an inlet having an inlet axis, and an outlet having an outlet axis. The inlet and the outlet are in fluid communication with the pumping chamber. The pump further includes an impeller rotatably disposed within the pumping chamber, and a strut connected to the housing at the inlet. The strut is connected to the housing at a circumferential position about the inlet axis such that a major axis of the strut and the outlet axis define a predetermined angle in a cross-sectional plane perpendicular to the inlet axis. The circumferential position of the strut relative the outlet axis reduces or eliminates damage to blood flowing around the strut.
A61M 60/113 - Extracorporeal pumps, i.e. the blood being pumped outside the patient’s body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
A61M 60/221 - Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller the blood flow through the rotating member having both radial and axial components, e.g. mixed flow pumps
A61M 60/422 - Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being electromagnetic, e.g. using canned motor pumps
A61M 60/825 - Contact bearings, e.g. ball-and-cup or pivot bearings
F04D 7/04 - Pumps adapted for handling specific fluids, e.g. by selection of specific materials for pumps or pump parts of centrifugal type the fluids being viscous or non-homogeneous
F04D 25/06 - Units comprising pumps and their driving means the pump being electrically driven
The present invention relates to an implantable pacing and/or defibrillation lead (10, 100, 200) wherein the electrical connection between active fixation electrode (22, 26, 126) and a distal housing portion (122, 222) of the lead (10, 100. 200) is realized by means of an electrically conductive compression spring (176, 276) is at least partially radially arranged around a tubular body (138, 238) of a guiding member (35, 136, 236) and a radial opening (158, 258) of the guiding member (136, 236), such that the electrically conductive compression spring (176, 126) is forced by its restoring force against a conductive driver shaft (120, 220) mechanically and electrically connected to the active fixation electrode (126, 226).
A blood processing apparatus may include a heat exchanger and a gas exchanger. At least one of the heat exchanger and the gas exchanger may be configured to impart a radial component to blow flow through the heat exchanger and/or gas exchanger. The heat exchanger may be configured to cause blood flow to follow a spiral flow path.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
A61M 1/16 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes
F28F 13/12 - Arrangements for modifying heat transfer, e.g. increasing, decreasing by affecting the pattern of flow of the heat-exchange media by creating turbulence, e.g. by stirring, by increasing the force of circulation
An oxygenator includes a housing having a blood inlet and a blood outlet, the blood inlet extending into an interior of the housing. A heat exchanger is disposed within the housing, and is coupled, at an inlet end, to a heat-exchange fluid inlet. A gas exchanger also is disposed within the housing, and includes a bundle of gas-exchange fibers coupled, at a gas outlet end, to a gas-exchange fluid outlet. The oxygenator includes at least one insulator configured to thermally insulate at least the gas outlet end of the bundle of gas-exchange fibers.
An assembly comprising an implanting accessory, and a stimulation lead. The lead configured to be combined with an active implantable medical device and implanted through a right ventricular free wall. The implanting accessory comprising a needle with a free puncturing end, where at least a first portion of the lead is configured to be inserted into an inner lumen of the needle. In a state where the first portion of the lead is inserted into the inner lumen, the first portion of the lead comprises at least a first branch that extends from the lead in a direction oriented toward the free puncturing end, the first branch extending from the lead from a junction point arranged a predetermined distance from a distal end of the lead, the predetermined distance corresponding to a second portion of the lead between the junction point and the distal end of the lead.
A method for titrating a stimulation parameter for one or more electrode contacts in a system for stimulating a hypoglossal nerve of a patient includes activating one of the one or more electrode contacts to stimulate the hypoglossal nerve of the patient, obtaining a first and/or second physiological measurement from the patient, comparing the first and/or second physiological measurement to a first and/or second predetermined target value, adjusting a stimulation parameter for the one of the one or more electrode contacts if the first and/or second physiological measurement differs from the first and/or second predetermined target value.
A mobile clean room is configured to provide a clean room environment while moving components between a first stationary clean room and a second stationary clean room. The mobile clean room includes an interior volume and an air quality system configured to maintain a clean room environment within the interior volume. The mobile clean room includes an on-board power supply, an electric tractor coupled to the mobile clean room and configured to move the mobile clean room, and a controller that is operably coupled with the filtration system and the on-board power supply. The controller is configured to monitor and control performance of the air quality system, monitor performance of the on-board power supply, and communicate with a stationary controller controlling operation of the first stationary clean room and/or the second stationary clean room.
F24F 3/167 - Clean rooms, i.e. enclosed spaces in which a uniform flow of filtered air is distributed
E04B 1/348 - Structures composed of units comprising at least considerable parts of two sides of a room, e.g. box-like or cell-like units closed or in skeleton form
F24F 11/52 - Indication arrangements, e.g. displays
G07C 9/00 - Individual registration on entry or exit
51.
BLOOD CONDITIONING ASSEMBLY FOR USE WITH AN EXTRACORPOREAL LIFE SUPPORT SYSTEM
A blood conditioning assembly for use with an extracorporeal life support system may include an oxygenator including a housing and a gas exchanger disposed within the housing, and an axial pump extending from the housing and configured to drive fluid flow through the oxygenator. The axial pump may be integrally formed with the housing of the oxygenator. The blood conditioning assembly may be devoid of external tubing between the axial pump and the oxygenator.
A61M 60/113 - Extracorporeal pumps, i.e. the blood being pumped outside the patient’s body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
A61M 1/16 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes
A61M 60/237 - Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller the blood flow through the rotating member having mainly axial components, e.g. axial flow pumps
A61M 60/422 - Details relating to driving for non-positive displacement blood pumps the force acting on the blood contacting member being electromagnetic, e.g. using canned motor pumps
52.
Dual Lumen Drainage Cannula With Internal Flow Restrictor
A dual lumen drainage cannula configured for use in a veno-arterial extracorporeal membrane oxygenation (VA ECMO) system includes a first drainage tube having a proximal end, a distal end, and at least one aperture defined proximate its distal end and in fluid communication with the lumen of the first drainage tube, and a second drainage tube having a proximal end, a distal end, and at least one aperture defined proximate its distal end and in fluid communication with the lumen of the second drainage tube. The dual lumen drainage cannula further includes a flow restrictor disposed within the lumen of at least one of the first and second drainage tubes, configured to adjust the flow distribution of blood flow through the lumens of the first and second drainage tubes.
A system including tubing and a filter configured to be fluidly coupled to a vacuum source and to a heater/cooler unit by the tubing. The filter includes a filter container having negative air pressure in the filter container provided by the vacuum source to pull aerosol from the heater/cooler unit into the filter container and eliminate and/or reduce the aerosol emitted from the heater/cooler unit.
A61M 1/00 - Suction or pumping devices for medical purposesDevices for carrying-off, for treatment of, or for carrying-over, body-liquidsDrainage systems
A61F 7/00 - Heating or cooling appliances for medical or therapeutic treatment of the human body
A61L 9/00 - Disinfection, sterilisation or deodorisation of air
A61L 9/16 - Disinfection, sterilisation or deodorisation of air using physical phenomena
A61M 1/16 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
A61M 19/00 - Devices for local anaesthesiaDevices for hypothermia
54.
Method and system for communication between a plurality of implantable medical devices
A method of communication in a system comprising plurality of implantable medical devices, where a first device comprises a means for detection of a signal representative of atrial activity, a transmitter, and a controller, and a second device independent of the first device, the second device comprising a receiver and a controller. The method comprises synchronizing the first device with the second device, determining the duration of a cardiac cycle, determining a synchronization interval, the duration of the synchronization interval determined as a function of the duration of the cardiac cycle, the synchronization interval being shorter than the duration of the cardiac cycle, and the start of the synchronization interval is determined as a function of the synchronization signal, and activating the receiver of the second device during the synchronization interval, wherein the receiver of the second device is deactivated outside of the synchronization interval.
Prosthetic heart valves described herein can be deployed using a transcatheter delivery system and technique to interface and anchor in cooperation with the anatomical structures of a native heart valve. Some embodiments of prosthetic valves described herein include an anchor portion that couples to the anatomy near a native valve, and a valve portion that is mateable with the anchor portion. In some such embodiments, the anchor portion and/or the deployment system includes one or more prosthetic elements that temporarily augment or replace the sealing function of the native valve leaflets.
A cardiac defibrillation system. The system comprising a housing and an implantable lead. The implantable lead comprising two ends, including a first end connected to the housing and a second end being a free end. The implantable lead also comprising a defibrillation electrode and at least three detection electrodes including a first detection electrode, a second detection electrode, and a third detection electrode. The first detection electrode and the second detection electrode forming a first dipole. The third detection electrode and the first detection electrode, or, the third detection electrode and the second detection electrode, or, the housing and one of said detection electrodes, forming a second dipole, where a length of the first dipole is between 5 and 50 millimeters and a length of the second dipole is between 50 and 400 millimeters.
Prosthetic mitral valves described herein can be deployed using a transcatheter mitral valve delivery system and technique to interface and anchor in cooperation with the anatomical structures of a native mitral valve. This document describes prosthetic heart valve designs and techniques to manage blood flow through the left ventricular outflow tract. For example, this document describes prosthetic heart valve designs and techniques that reduce or prevent obstructions of the left ventricular outflow tract that may otherwise result from systolic anterior motion of an anterior leaflet of the native mitral valve.
This invention relates to a method and system for determining and/or tracking a heart function of a patient, wherein the heart function is estimated by combining information representative of an electrical, mechanical and/or hemodynamic heart function received from imaging, therapy and/or diagnosis systems or a patient database with real-time information representative of an electrical, mechanical and/or hemodynamic heart function received from a measuring device attached or implanted to the patient. The information and the real-time information from can be associated to update an evaluation of the heart function of the patient in real-time and thereby improve the heart function and possibly optimize its efficiency.
An apparatus includes a blood-flow-management assembly shaped to define a cylindrical aperture. The blood-flow-management assembly includes a blood collector having drainage holes configured to direct blood to a guide surface positioned below the blood collector. The guide surface may further include ribs that manage blood flow along the guide surface.
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
A61M 60/113 - Extracorporeal pumps, i.e. the blood being pumped outside the patient’s body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
60.
ORGAN PERFUSION AND PRESERVATION SYSTEM AND METHOD
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (France)
ASSISTANCE PUBLIQUE – HOPITAUX DE PARIS (France)
Inventor
Migliazza, John F.
Spiritelli, Sandra
Scatton, Olivier
Savier, Eric
Goumard, Claire
Abstract
An organ perfusion and preservation system for use in preserving an organ (80) from a donor, may include a fluid reservoir (10), a heat exchanger (50) in fluid communication with the fluid reservoir and configured to selectively raise and lower a temperature of a perfusion fluid, an oxygenator (40), an inflow pump (32) in fluid communication with the fluid reservoir and the oxygenator, a fluid inflow line (42) configured to transport perfusion fluid from the oxygenator to the organ, a fluid outflow line (44) configured to transport perfusion fluid away from the organ and back to the reservoir, an outflow pump (34) in fluid communication with the fluid outflow line and the fluid reservoir, and a controller (90) operatively connected to the inflow pump, the outflow pump, and the heat exchanger, wherein the controller is configured to select parameters to reversibly heat and reversibly cool the organ.
A bi-directional perfusion cannula is provided that includes an elongate tube for insertion into an artery. The elongate tube has a first aperture at a distal end of the tube which is forward during insertion and configured so that blood can flow into the artery in the direction of insertion, an elbow formed in the elongate tube, and a second aperture formed in or slightly rearward of the elbow and configured for supplying blood into the artery in a second direction which is generally opposite to the insertion direction.
A blood processing apparatus includes an optional heat exchanger and a gas exchanger disposed within a housing. In some instances, the gas exchanger can include a screen filter spirally wound into the gas exchanger such that blood passing through the gas exchanger passes through the screen filter and is filtered by the spirally wound screen filter a plurality of times.
A device for conditioning blood including a heat exchanger module including a heat exchanger fiber layer including heat exchanger fibers to receive a heat exchanger fluid and exchange heat with the blood, a gaseous micro-emboli removal module including a micro-porous fiber layer including micro-porous fibers to receive atmospheric or sub-atmospheric pressures such that at least some gaseous micro-emboli are drawn from the blood through the micro-porous fibers, a gas exchanger module including a gas exchanger fiber layer including gas exchanger fibers to receive a gas mixture and exchange gas with the blood, and a potting material body that embeds the heat exchanger fibers, the micro-porous fibers, and the gas exchanger fibers and defines a blood compartment that extends through the heat exchanger module, the gaseous micro-emboli removal module, and the gas exchanger module.
A monitoring system for cardiac operations with cardiopulmonary bypass comprising: a processor operatively connected to a heart-lung machine; a pump flow detecting device connected to a pump of the heart-lung machine to continuously measure the pump flow value and send it to the processor; a hematocrit reading device inserted inside the arterial or venous line of the heart-lung machine to continuously measure the blood hematocrit value and to send it to the processor; a data input device to allow the operator to manually input data regarding the arterial oxygen saturation and the arterial oxygen tension; computing means integrated in the processor to compute the oxygen delivery value on the basis of the measured pump flow, the measured hematocrit value, the preset value of arterial oxygen saturation, and the preset value of arterial oxygen tension; and a display connected to the processor to display in real-time the computed oxygen delivery value.
A61B 5/145 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
A61B 5/0205 - Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
G16H 40/63 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for local operation
G16Z 99/00 - Subject matter not provided for in other main groups of this subclass
G16H 20/00 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
G16H 50/30 - ICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indicesICT specially adapted for medical diagnosis, medical simulation or medical data miningICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for individual health risk assessment
A61B 5/08 - Measuring devices for evaluating the respiratory organs
A61B 5/00 - Measuring for diagnostic purposes Identification of persons
A dual lumen drainage cannula configured for use in a VA ECMO system includes a first drainage tube having a proximal end, a distal end, and at least one aperture in at least one wall of the first drainage tube proximate to the distal end of the first drainage tube, and a second drainage tube having a proximal end, a distal end, and at least one aperture in at least one wall of the second drainage tube proximate to the distal end of the second drainage tube. The first drainage tube passes through the second drainage tube. The dual lumen drainage cannula also includes a sleeve positioned adjacent to an interior wall of the second drainage tube. The sleeve is formed of a flexible material so as to be expandable and collapsible within the second drainage tube.
A blood reservoir may be used in combination with other elements such as a heart lung machine (HLM), oxygenator, heat exchanger, arterial filter and the like to form an extracorporeal blood circuit that may be employed in a procedure such as a bypass procedure. The blood reservoir may be configured to receive, filter and store blood from a number of sources including vent blood (from within the heart), venous blood (from a major vein), purge blood (from a sampling line) and cardiotomy or suction blood (from the surgical field).
A communication system for enabling a writing operation in a memory of an implantable medical device. The communication system includes an intermediate proximity device configured to receive writing data transmitted by a main writing device, the intermediate proximity device configured to communicate with the implantable medical device. The system also includes a first external unlocking tool configured to transmit a detectable signal when the first external unlocking tool is located within a predetermined perimeter of the implantable medical device, where the intermediate proximity device is configured to cause the implantable medical device to write the writing data into the memory of the implantable medical device when the first external unlocking tool is in the predetermined perimeter of the implantable medical device.
A method of delivering a valve prosthesis to be deployed within a native heart valve at a native heart valve annulus. The method including collapsing a prosthetic valve having an expandable frame comprising a proximal end and a distal end and a longitudinal axis extending therethrough inside of a delivery instrument, such that a plurality of spaced anchors extending from the distal end of the expandable frame towards the proximal end are collapsed to an inverted position in a collapsed anchor configuration. The method further including advancing the delivery instrument a first distance such that the plurality of spaced anchors extend below the valve annulus, and releasing each of the plurality of spaced anchors such that each of the plurality of spaced anchors is repositioned from the inverted position to an expanded anchor configuration to contact a subannular location.
Prosthetic heart valves described herein can be deployed using a transcatheter delivery system and technique to interface and anchor in cooperation with the anatomical structures of a native heart valve. In some embodiments, composite two-portion prosthetic heart valves in which two expandable components are attached to each other can be arranged in a nested configuration during both the transcatheter delivery process and the deployment process within the heart. Deployment systems and methods for using the deployment systems described herein facilitate implanting the composite two-portion prosthetic heart valves that are attached and arranged in a nested configuration during the transcatheter delivery and deployment processes.
A61F 2/966 - Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve with relative longitudinal movement between outer sleeve and prosthesis, e.g. using a push rod
70.
OXYGENATOR WITH WOUND FILTER MEMBRANE AND FLOW DIFFUSER
A blood oxygenator has a housing with a first end opposite a second end and a sidewall extending between the first end and the second end along a longitudinal axis. The housing may define an interior chamber having a fluid inlet and a fluid outlet. The blood oxygenator further has a gas exchange medium positioned within the interior chamber. The gas exchange medium may have a plurality of hollow fibers rolled into a spiral shape. The blood oxygenator further has a flow diverter positioned within the interior chamber and configured for guiding fluid flow through the gas exchange medium.
(1) A Medical device system, comprised of an oxygenator(s) for extracorporeal respiratory support combined with a percutaneous assist device, namely, blood pump(s) and cannula(s) to form a singular circuit for support of the native circulatory system. The medical device system is inserted through the skin utilizing the cannula(s) as a conduit for augmenting the flow of blood and oxygen during acute cardiopulmonary failure and/or circulatory support during cardiac intervention
A valve prosthesis to be deployed within a native heart valve at a native heart valve annulus. The valve prosthesis including an expandable frame and a plurality of spaced anchors. The expandable frame includes a proximal end and a distal end and a longitudinal axis extending therethrough. The expandable frame collapses radially for delivery and expands radially upon deployment to an expanded configuration. The plurality of spaced anchors extend from the distal end of the frame towards the proximal end, each anchor formed with a free end, and each anchor being expandable from a collapsed anchor configuration to an expanded anchor configuration, wherein each of the anchors includes a foot angle of from 0 to 45 degrees relative to the longitudinal axis.
The present invention relates to a step-up converter with a plurality of levels, in particular for use in an implantable medical device, comprising a transformer (11) comprising a single primary winding and a single secondary winding; a primary circuit (6) comprising the single primary winding; and a secondary circuit (7) comprising the single secondary winding and a plurality of step-up levels, each of the step-up levels comprising a first diode (4a, 4b, 4c, 4d, 4e, 4f) and a second diode (10a, 10b, 10c, 10d, 10e, 10f) and a first capacitor (9a, 9b, 9c, 9d, 9e, 9f) and a second capacitor (3a, 3b, 3c, 3d, 3e, 3f), wherein the first capacitors (9a, 9b, 9c, 9d, 9e, 9f) of the plurality of step-up levels are connected in series or in parallel with one another. The present invention also relates to an implantable medical device comprising the step-up converter with a plurality of levels mentioned above, and a method for using the step-up converter with a plurality of levels or the implantable device mentioned above.
H02M 3/335 - Conversion of DC power input into DC power output with intermediate conversion into AC by static converters using discharge tubes with control electrode or semiconductor devices with control electrode to produce the intermediate AC using devices of a triode or a transistor type requiring continuous application of a control signal using semiconductor devices only
H02M 7/10 - Conversion of AC power input into DC power output without possibility of reversal by static converters using discharge tubes without control electrode or semiconductor devices without control electrode arranged for operation in series, e.g. for multiplication of voltage
A61N 1/36 - Applying electric currents by contact electrodes alternating or intermittent currents for stimulation, e.g. heart pace-makers
A dual lumen drainage cannula configured for use in a veno-arterial extracorporeal membrane oxygenation (VA ECMO) system includes a first drainage tube having a proximal end, a distal end, and at least one aperture defined in the distal end. The dual lumen drainage cannula further includes a second drainage tube having a proximal end, a distal end, and at least one aperture defined in the distal end. The dual lumen drainage cannula further includes an outlet fitting in fluid communication with the first drainage tube and the second drainage tube. The distal end of the second drainage tube is joined to a portion of the first drainage tube between the proximal and distal ends of the first drainage tube.
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
A61M 60/113 - Extracorporeal pumps, i.e. the blood being pumped outside the patient’s body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
A blood oxygenator includes a housing having a first end opposite a second end with a sidewall extending between the first end and the second end along a longitudinal axis. The housing defines an interior chamber having a liquid inlet at the first end and a liquid outlet at the second end. The oxygenator further includes a gas exchange assembly positioned within the interior chamber. The gas exchange assembly includes a retainer having an upper cap spaced apart from a lower cap by one or more spacers, and a gas exchange medium disposed between the upper cap and the lower cap. The gas exchange medium has a plurality of subunits stacked on top of each other, with each subunit having a plurality of layers of hollow fiber mats.
A system for removing gaseous micro emboli from blood prior to oxygenation. The system including a module having a blood inlet, a blood outlet, and a port configured to provide atmospheric or sub-atmospheric pressures, and microporous hollow fibers situated in the module and fluidly coupled to the port to provide the atmospheric or sub-atmospheric pressures inside the microporous hollow fibers. The module is configured to receive the blood through the blood inlet such that the blood flows from the blood inlet to the blood outlet around outside surfaces of the microporous hollow fibers such that at least some of the gaseous micro emboli in the blood are drawn from the blood through the microporous hollow fibers by the atmospheric or sub-atmospheric pressures.
B01D 53/22 - Separation of gases or vapoursRecovering vapours of volatile solvents from gasesChemical or biological purification of waste gases, e.g. engine exhaust gases, smoke, fumes, flue gases or aerosols by diffusion
A61M 1/16 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
A blood oxygenator includes a housing having a blood inlet, a blood outlet, a gas inlet, and a gas outlet; and a gas exchange medium having a plurality of hollow fibers in fluid communication with the gas inlet and the gas outlet. Each of the hollow fibers has a roughened outer surface configured to decrease a thickness of a boundary layer at an interface between blood and the roughened outer surface and increase a gas exchange rate at the interface.
A61M 1/16 - Dialysis systemsArtificial kidneysBlood oxygenators with membranes
B01D 69/02 - Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or propertiesManufacturing processes specially adapted therefor characterised by their properties
A purger device for hollow fiber oxygenators, including a gas inlet, a gas outlet, and a fluid communication feature between the gas inlet and the gas outlet. The purger device further including an accumulation chamber having a variable volume plenum ported to the fluid communication feature, and a flow control unit configured to vary fluid communication patterns in the fluid communication feature and having a first operating condition and a second operating condition, wherein in the first operating condition the flow control unit enables a fluid communication between the gas inlet and gas outlet, and wherein in the second operating condition the flow control unit enables a fluid communication between the gas inlet and the variable volume plenum of the accumulation chamber.
The present invention relates to an implantable pacing and/or defibrillation lead (10, 100, 200) wherein the electrical connection between active fixation electrode (22, 26, 126) and a distal housing portion (122, 222) of the lead (10, 100. 200) is realized by means of an electrically conductive compression spring (176, 276) is at least partially radially arranged around a tubular body (138, 238) of a guiding member (35, 136, 236) and a radial opening (158, 258) of the guiding member (136, 236), such that the electrically conductive compression spring (176, 126) is forced by its restoring force against a conductive driver shaft (120, 220) mechanically and electrically connected to the active fixation electrode (126, 226).
The present invention relates to an assembly consisting of an implanting accessory comprising a needle (13) and of a flexible implantable stimulation probe. In a state in which a first portion (24) of the probe (14) is inserted into the lumen (17) of the needle (13), said first portion (24) of the probe (14) comprises at least one first branch (26) which extends from the probe body (16) in a direction (D) oriented towards the pointed free end (15) of the needle (13), the first branch (26) extending from the probe body (16) at a predetermined distance (L1) from the distal end (22), said distance corresponding to a second portion (28) of the probe body (16) between the first branch (26) and the distal end (22) of the probe (14),
The present invention relates to a device for monitoring operation of a probe of an implantable active cardiac device, in particular an implantable automated defibrillator or a defibrillator for cardiac resynchronisation, comprising a parameter-determining device for determining values of a plurality of parameters characterising the probe, a processing unit configured to determine values representative of at least one parameter of the plurality of parameters characterising the probe on at least two different timescales, the processing unit furthermore being configured to compare a value, called the analysis value, of at least one parameter of the plurality of parameters characterising the probe with the values representative of said parameter.
A dual lumen coaxial cannula assembly includes a first infusion tube having a first elongate body defining a first lumen therethrough and a second drainage tube co-axially aligned with the first infusion tube and having a second elongate body with a second lumen defined by a space between the first infusion tube and second drainage tube. A connector is removably attached to the first infusion tube and the second drainage tube for coupling the dual lumen coaxial cannula to an extracorporeal blood circuit. The first infusion tube and the second drainage tube include a plurality of infusion and drainage apertures, respectively, provided at the distal end and extending through the sidewall of the first infusion tube and the drainage tube, respectively.
A61M 60/113 - Extracorporeal pumps, i.e. the blood being pumped outside the patient’s body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
Prosthetic heart valves described herein can be deployed using a transcatheter delivery system and technique to interface and anchor in cooperation with the anatomical structures of a native heart valve. Deployment systems and methods for using the deployment systems described herein facilitate implanting a two-part prosthetic heart valve that is arranged in a nested configuration during the transcatheter delivery and deployment processes.
A system includes a cuvette including a cuvette body forming a substantially planar exterior surface and having a sensor window defined within the substantially planar exterior surface. The cuvette further includes a probe retention structure extending from the cuvette body. The system includes a probe with a probe body and a protrusion that is removably coupled to the probe retention structure.
A61B 5/1455 - Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value using optical sensors, e.g. spectral photometrical oximeters
Prosthetic heart valves described herein can be deployed using a transcatheter delivery system and technique to interface and anchor in cooperation with the anatomical structures of a native heart valve. Deployment systems and methods for using the deployment systems described herein facilitate accurately and conveniently controllable percutaneous, transcatheter techniques by which the prosthetic heart valves can be delivered and deployed within a patient.
A61B 1/00 - Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopesIlluminating arrangements therefor
A61M 25/01 - Introducing, guiding, advancing, emplacing or holding catheters
A61F 2/95 - Instruments specially adapted for placement or removal of stents or stent-grafts
A dual lumen coaxial cannula, assembly includes a first infusion tube having a first elongate body defining a first lumen therethrough and a second drainage tube co-axially aligned with the first infusion tube and having a second elongate body with a second lumen defined by a space between the first infusion tube and second drainage tube. A connector is removably attached to the first infusion tube and the second drainage tube for coupling the dual lumen coaxial cannula to an extracorporeal blood circuit. The first infusion tube and the second drainage tube include a plurality of infusion and drainage apertures, respectively, provided at the distal end and extending through the sidewall of the first infusion tube and the drainage tube, respectively.
A61M 60/13 - Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient’s body implantable via, into, inside, in line, branching on, or around a blood vessel by means of a catheter allowing explantation, e.g. catheter pumps temporarily introduced via the vascular system
A61M 60/165 - Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient’s body implantable in, on, or around the heart
A61M 60/113 - Extracorporeal pumps, i.e. the blood being pumped outside the patient’s body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
The present disclosure relates to an implantable lead comprising an elongated lead body having at least one lumen therein and at least one through hole, and at least one electrically conductive wire. For at least one of said at least one lumen, a first through hole extends from an outer surface of the lead body into said lumen, and an electrically conductive wire is arranged in said lumen at least on one side of said first through hole. Furthermore, said electrically conductive wire is further arranged in a configuration exiting the lumen via said first through hole and wound around a predefined portion of the outer surface of the lead body.
Medical device systems comprised of oxygenators for extracorporeal respiratory support combined with percutaneous assist devices in the nature of blood pumps and cannulas to form a singular circuit for support of the native circulatory system; medical device systems inserted through the skin utilizing the cannula as a conduit for augmenting the flow of blood and oxygen during acute cardiopulmonary failure and circulatory support during cardiac intervention
A blood processing apparatus may include a heat exchanger and a gas exchanger. At least one of the heat exchanger and the gas exchanger may be configured to impart a radial component to blow flow through the heat exchanger and/or gas exchanger. The heat exchanger may be configured to cause blood flow to follow a spiral flow path.
F28D 7/10 - Heat-exchange apparatus having stationary tubular conduit assemblies for both heat-exchange media, the media being in contact with different sides of a conduit wall the conduits being arranged one within the other, e.g. concentrically
F28D 7/16 - Heat-exchange apparatus having stationary tubular conduit assemblies for both heat-exchange media, the media being in contact with different sides of a conduit wall the conduits being arranged in parallel spaced relation
F28D 21/00 - Heat-exchange apparatus not covered by any of the groups
F28F 13/06 - Arrangements for modifying heat transfer, e.g. increasing, decreasing by affecting the pattern of flow of the heat-exchange media
F28F 21/06 - Constructions of heat-exchange apparatus characterised by the selection of particular materials of plastics material
90.
Dual lumen cannula with adjustable length infusion tube
A dual lumen coaxial cannula assembly including a first infusion tube having a proximal end, a distal end, and a sidewall extending circumferentially therebetween, as well as a second drainage tube co-axially aligned with the first infusion tube, the second drainage tube having a proximal end, a distal end, and a sidewall extending circumferentially therebetween. The assembly also includes a connector assembly, which has an inlet portion through which a portion of the first infusion tube is configured to extend and an outlet portion through which a portion of the second drainage tube is configured to extend. The connector assembly is configured to enable selective axial displacement of the first infusion tube through the second drainage tube.
The present invention relates to a wireless communication method and a multi-device system configured to implement said method for adjusting and adapting communication windows to a patient's electrophysiological rhythm. Each device in the system is configured to determine a time marker (Pref1 n, Pref2 n) associated with the detection of a PQRST complex wave and to rearrange the communication window in accordance with the time marker thus determined for each cardiac cycle.
A61N 1/365 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential
A61N 1/372 - Arrangements in connection with the implantation of stimulators
A61N 1/375 - Constructional arrangements, e.g. casings
G16H 20/30 - ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
G16H 40/60 - ICT specially adapted for the management or administration of healthcare resources or facilitiesICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
Systems and methods for medical interventional procedures, including approaches to valve implant. In one aspect, the methods and systems involve a modular approach to treatment.
Disclosed are systems, devices and methods that produce at least two distinct temporal components from two distinct endocardial electrogram (EGM) signals collected concurrently, determines a non-temporal 2D characteristic representative of the cardiac cycle to be analyzed, from the variations of one of the temporal components as a function of another of the temporal components and comparing the characteristic of the current cycle to two reference characteristics previously obtained and stored, one in a situation of complete capture and the other in a situation of spontaneous rhythm. Respective values of similarity descriptors are derived of these two comparisons, which are used to calculate a metric quantifying a fusion rate.
A61N 1/368 - Heart stimulators controlled by a physiological parameter, e.g. by heart potential comprising more than one electrode co-operating with different heart regions
A device for conditioning blood including a heat exchanger module including a heat exchanger fiber layer including heat exchanger fibers to receive a heat exchanger fluid and exchange heat with the blood, a gaseous micro-emboli removal module including a micro-porous fiber layer including micro-porous fibers to receive atmospheric or sub-atmospheric pressures such that at least some gaseous micro-emboli are drawn from the blood through the micro-porous fibers, a gas exchanger module including a gas exchanger fiber layer including gas exchanger fibers to receive a gas mixture and exchange gas with the blood, and a potting material body that embeds the heat exchanger fibers, the micro-porous fibers, and the gas exchanger fibers and defines a blood compartment that extends through the heat exchanger module, the gaseous micro-emboli removal module, and the gas exchanger module.
A cannula includes a tube having a proximal end, a distal end, and a tubular sidewall extending between the proximal end and the distal end. The cannula further includes an extendable member provided on a portion of the sidewall. The extendable member is configured to extend radially outward from the sidewall. The sidewall defines an aperture located between the proximal end and the distal end of the main tube.
A cannula includes a tube having a proximal end, a distal end, and a tubular sidewall extending between the proximal end and the distal end. The cannula further includes an extendable member provided on a portion of the sidewall. The extendable member is configured to extend radially outward from the sidewall. The sidewall defines an aperture located between the proximal end and the distal end of the main tube.
A dual lumen drainage cannula (10) configured for use in a VA ECMO system includes a first drainage tube (12) having a proximal end, a distal end, and at least one aperture (18) in at least one wall of the first drainage tube (12) proximate to the distal end of the first drainage tube, and a second drainage tube (14) having a proximal end, a distal end, and at least one aperture (20) in at least one wall of the second drainage tube proximate to the distal end of the second drainage tube. The first drainage tube (12) passes through the second drainage tube (14). The dual lumen drainage cannula (10) also includes a sleeve (16) positioned adjacent to an interior wall of the second drainage tube. The sleeve (16) is formed of a flexible material so as to be expandable and collapsible within the second drainage tube.
A dual lumen drainage cannula configured for use in a VA ECMO system includes a first drainage tube having a proximal end, a distal end, and at least one aperture in at least one wall of the first drainage tube proximate to the distal end of the first drainage tube, and a second drainage tube having a proximal end, a distal end, and at least one aperture in at least one wall of the second drainage tube proximate to the distal end of the second drainage tube. The first drainage tube passes through the second drainage tube. The dual lumen drainage cannula also includes a sleeve positioned adjacent to an interior wall of the second drainage tube. The sleeve is formed of a flexible material so as to be expandable and collapsible within the second drainage tube.
An extracorporeal blood cooling or heating circuit includes an intravenous catheter for withdrawing a patient's blood coupled to a combined pump/heat exchanger device. One or more sensors are provided upstream and/or downstream of the pump/heat exchanger device for measuring pressure, temperature, fluid flow, blood oxygenation, and other parameters, A controller is operative!}′ coupled to the pump/heat exchanger device and the one or more sensors to control the speed of the pump inside the pump/heat exchanger device and regulate the blood temperature by controlling the operation of the heat exchanger. The combined pump/heat exchanger device includes a housing having at least one inlet and at least one outlet, a pump portion defining a blood circuit inside the housing, and a heat exchanger portion contained within the housing for selectively heating or cooling the blood.
A61M 1/36 - Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation
F28D 7/16 - Heat-exchange apparatus having stationary tubular conduit assemblies for both heat-exchange media, the media being in contact with different sides of a conduit wall the conduits being arranged in parallel spaced relation
100.
Dual multipolar lead implantable in the coronary venous network
The disclosure relates to a multipolar, detection/stimulation endovascular lead intended to be implanted in the coronary venous network. The lead comprises a lead body with in proximal portion a connector to a cardiac pacemaker/defibrillator generator, and in a distal portion a first branch and a second branch extending beyond a bifurcation. The distal ends of the branches are free ends carrying an array of electrodes connected to the connector. Each of the branches comprises at its free end an outlet in the distal direction, able to receive an implantation guide wire inserted therein and to guide the implantation guide wire in an axial direction parallel to the main axis of the lead body.
