Abstract

This invention relates to the use of S. pneumoniae protein antigens, such as NanA, PluA and Sp0148, as carriers for immunogenic S. pneumoniae capsular polysaccharide. This may be useful for example in glycoconjugate vaccines able to generate a protective immune response against multiple capsuler serotypes. Glycoconjugates, vaccine compositions and methods of manufacture and use are provided.

IPC Classes  ?

• A61K 39/385 - Haptens or antigens, bound to carriers
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/09 - Streptococcus
• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• A61P 31/04 - Antibacterial agents
• C07K 14/315 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci

Abstract

This invention relates to the use of S. pneumoniaeprotein antigens, such as NanA, PiuA and Sp0148, as carriersfor immunogenic S. pneumoniaecapsular polysaccharide. This may be useful for example in glycoconjugate vaccinesable to generate a protective immune response against multiplecapsular serotypes.Glycoconjugates, vaccine compositions and methods of manufacture and use are provided.

IPC Classes  ?

• A61K 39/09 - Streptococcus
• A61K 39/385 - Haptens or antigens, bound to carriers
• C07K 14/315 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
• C08B 37/00 - Preparation of polysaccharides not provided for in groups Derivatives thereof
• A61P 31/04 - Antibacterial agents
• C12N 9/10 - Transferases (2.)
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

The present invention provides compounds for attracting bed bugs, compositions thereof, devices comprising said compositions and their use in the detection, monitoring and control of bed bugs.

IPC Classes  ?

• A01N 35/02 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aliphatically bound aldehyde or keto groups, or thio-analogues thereofDerivatives thereof, e.g. acetals
• A01N 37/02 - Saturated carboxylic acids or thio-analogues thereofDerivatives thereof
• A01N 35/04 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aldehyde or keto groups, or thio-analogues thereof, directly attached to an aromatic ring system, e.g. acetophenoneDerivatives thereof, e.g. acetals
• A01N 31/02 - Acyclic compounds
• A01N 27/00 - Biocides, pest repellants or attractants, or plant growth regulators containing hydrocarbons

Abstract

The invention relates to an isolated African horse sickness virus (AHSV) ssRNA comprising a plurality of mutations; a complementary cell for replication of a vaccinal viral strain from said ssRNA; a vaccinal viral strain derived from said ssRNA; use of said vaccinal viral strain and/or isolated ssRNA in the vaccination of an animal against an infection by AHSV; a method of vaccination comprising same; and a pharmaceutical composition comprising said vaccinal viral strain and/or said isolated ssRNA.

IPC Classes  ?

• A61K 39/15 - Reoviridae, e.g. calf diarrhea virus
• A61K 39/12 - Viral antigens
• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• A61K 39/00 - Medicinal preparations containing antigens or antibodies

Abstract

In some embodiments, an immunoassay device for detection of recent malaria infection includes: a sample pad positioned adjacent to a first end of a conjugate pad, wherein either the sample pad or the first end of the conjugate pad include a detection complex able to bind anti-ETRAMP5 antibodies; wherein a second end of the conjugate pad includes one or more areas impregnated with a construct protein including ETRAMP5 protein fragments. In some embodiments, the detection complex for anti-ETRAMP5 antibodies includes a capture particle complexed with anti-IgG antibodies. In some embodiments, the detection complex for anti-ETRAMP5 antibodies includes a detection particle complexed with a complex molecule including ETRAMP5 protein fragments.

IPC Classes  ?

• G01N 33/569 - ImmunoassayBiospecific binding assayMaterials therefor for microorganisms, e.g. protozoa, bacteria, viruses
• G01N 33/558 - ImmunoassayBiospecific binding assayMaterials therefor using diffusion or migration of antigen or antibody
• G01N 33/68 - Chemical analysis of biological material, e.g. blood, urineTesting involving biospecific ligand binding methodsImmunological testing involving proteins, peptides or amino acids

Abstract

The disclosure relates to aglycoconjugate vaccine conferring protection against Francisella tularensisinfections and a method to manufacture a glycoconjugate antigen

IPC Classes  ?

• A61K 39/02 - Bacterial antigens
• A61K 45/06 - Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• C07K 14/21 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria from Pseudomonadaceae (F)
• C12M 1/00 - Apparatus for enzymology or microbiology
• A61K 47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• C07K 14/195 - Peptides having more than 20 amino acidsGastrinsSomatostatinsMelanotropinsDerivatives thereof from bacteria

Abstract

The invention relates to an isolated African horse sickness virus (AHSV) ssRNA comprising a plurality of mutations; a complementary cell for replication of a vaccinal viral strain from said ssRNA; a vaccinal viral strain derived from said ssRNA; use of said vaccinal viral strain and/or isolated ssRNA in the vaccination of an animal against an infectionby AHSV; a method of vaccination comprising same; and a pharmaceutical composition comprising said vaccinal viral strain and/or said isolated ssRNA.

IPC Classes  ?

• C12N 15/46 - Reoviridae, e.g. rotavirus, bluetongue virus, Colorado tick fever virus
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 39/15 - Reoviridae, e.g. calf diarrhea virus
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof
• C12N 7/04 - Inactivation or attenuationProducing viral sub-units

Abstract

The invention relates to an isolated African horse sickness virus (AHSV) ssRNA comprising a plurality of mutations; a complementary cell for replication of a vaccinal viral strain from said ssRNA; a vaccinal viral strain derived from said ssRNA; use of said vaccinal viral strain and/or isolated ssRNA in the vaccination of an animal against an infectionby AHSV; a method of vaccination comprising same; and a pharmaceutical composition comprising said vaccinal viral strain and/or said isolated ssRNA.

IPC Classes  ?

• C12N 15/46 - Reoviridae, e.g. rotavirus, bluetongue virus, Colorado tick fever virus
• C12N 7/04 - Inactivation or attenuationProducing viral sub-units
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• A61K 31/7105 - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
• A61K 39/15 - Reoviridae, e.g. calf diarrhea virus
• C12N 7/00 - Viruses, e.g. bacteriophagesCompositions thereofPreparation or purification thereof

Abstract

The present invention provides compounds for attracting bed bugs, compositions thereof, devices comprising said compositions and their use in the detection, monitoring and control of bed bugs.

IPC Classes  ?

• A01N 35/02 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aliphatically bound aldehyde or keto groups, or thio-analogues thereofDerivatives thereof, e.g. acetals
• A01N 25/00 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests
• A01N 27/00 - Biocides, pest repellants or attractants, or plant growth regulators containing hydrocarbons
• A01N 31/02 - Acyclic compounds
• A01N 35/04 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aldehyde or keto groups, or thio-analogues thereof, directly attached to an aromatic ring system, e.g. acetophenoneDerivatives thereof, e.g. acetals
• A01N 37/02 - Saturated carboxylic acids or thio-analogues thereofDerivatives thereof
• A01P 19/00 - Pest attractants

Abstract

The present invention provides compounds for attracting bed bugs, compositions thereof, devices comprising said compositions and their use in the detection, monitoring and control of bed bugs.

IPC Classes  ?

• A01N 35/02 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aliphatically bound aldehyde or keto groups, or thio-analogues thereofDerivatives thereof, e.g. acetals
• A01N 31/02 - Acyclic compounds
• A01N 27/00 - Biocides, pest repellants or attractants, or plant growth regulators containing hydrocarbons
• A01N 35/04 - Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aldehyde or keto groups, or thio-analogues thereof, directly attached to an aromatic ring system, e.g. acetophenoneDerivatives thereof, e.g. acetals
• A01N 37/02 - Saturated carboxylic acids or thio-analogues thereofDerivatives thereof
• A01N 25/00 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests
• A01P 19/00 - Pest attractants

Abstract

The invention relates to an adapter for modifying a mobile communication device such as, but not limited to,a smartphone,tablet computers or webcam to create an ophthalmoscope or fundus camera for ophthalmoscopy or fundus imaging comprising an illumination device,including component parts thereof; and a method of testing eye function and producing images using said camera and associated illumination device. The invention has application in both the medical and veterinary practices.

IPC Classes  ?

• A61B 3/12 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
• A61B 3/10 - Objective types, i.e. instruments for examining the eyes independent of the patients perceptions or reactions
• A61B 3/14 - Arrangements specially adapted for eye photography

Abstract

The invention concerns a pharmaceutical composition for treating a viral infection caused by a member of the Reoviridae family; a method of treatment involving the use of same and use of the anti-viral to treat said viral infection. The agent has use in both humans and animals.

IPC Classes  ?

• C12N 15/113 - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
• A61K 31/7088 - Compounds having three or more nucleosides or nucleotides

Abstract

Spatial frequency swept interference (SFSI) illumination and imaging methods and devices that interfere two collimated coherent beams to generate an interference pattern of a plurality of illuminating sheets with sweeping spatial frequency.

IPC Classes  ?

• G02B 5/18 - Diffracting gratings
• G02B 21/00 - Microscopes
• G02B 21/36 - Microscopes arranged for photographic purposes or projection purposes
• G02B 27/58 - Optics for apodization or superresolutionOptical synthetic aperture systems

Abstract

A device and method for performing fluorescence imaging with digitally time reversed ultrasound encoded light, using a source of ultrasound waves, a coherent light source, a digital optical phase conjugation (DOPC) device comprising a camera and a spatial light modulator (SLM), a detector of fluorescence, and one or more computers, to obtain an output that at least approximates an interaction between a complete time reversed field, of all of the encoded light's fields, and the scattering medium.

IPC Classes  ?

• G02F 1/11 - Devices or arrangements for the control of the intensity, colour, phase, polarisation or direction of light arriving from an independent light source, e.g. switching, gating or modulatingNon-linear optics for the control of the intensity, phase, polarisation or colour based on acousto-optical elements, e.g. using variable diffraction by sound or like mechanical waves
• H04N 5/30 - Transforming light or analogous information into electric information
• A61N 5/00 - Radiation therapy
• G01N 27/447 - Systems using electrophoresis

Abstract

A device, including one or more Communication Physical Unclonable Function (CPUF) and key storage devices, the CPUF devices each including: a coherent Electromagnetic (EM) radiation source; a spatial light modulator (SLM) connected to the coherent EM radiation source; a volumetric scattering medium connected to the SLM; a detector connected to the volumetric scattering medium; and one or more processors or circuits connected to the detector and one or more processors or circuits connected to the SLM. A communication protocol is also provided.

IPC Classes  ?

• H04L 29/06 - Communication control; Communication processing characterised by a protocol
• H04L 9/28 - Arrangements for secret or secure communicationsNetwork security protocols using particular encryption algorithm
• H04L 9/06 - Arrangements for secret or secure communicationsNetwork security protocols the encryption apparatus using shift registers or memories for blockwise coding, e.g. D.E.S. systems
• H04L 9/08 - Key distribution
• H04L 27/227 - Demodulator circuitsReceiver circuits using coherent demodulation
• H04L 27/38 - Demodulator circuitsReceiver circuits

Abstract

A light guided pixel having a guide layer and a light detector layer. The guide layer has a light guide. The light detector layer has a light detecting element that receives light channeled by the light guide. The light guide may include a filter for channeling emissions to the light detecting element.

IPC Classes  ?

• H01L 27/146 - Imager structures

Abstract

A light microscope for imaging a sample containing one or more fluorescent agents, comprising a source for generating acoustic waves that are focused at a focus in the sample, wherein the acoustic waves frequency shift a frequency of light passing through the focus, thereby creating a frequency shifted light beam; at least one spatial light modulator (SLM) positioned to illuminate the sample with an output beam that is an optical phase conjugate of the frequency shifted light beam, wherein the output beam is a reflection of a first reference beam off one or more pixels of the SLM, and the pixels are for modulating the first reference beam to create the output beam; and a detector positioned to detect fluorescence generated by the output beam exciting the fluorescent agents at the focus in the sample, thereby imaging the sample.

IPC Classes  ?

• H01L 27/00 - Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate

Abstract

The invention relates to a lure for attracting, and in some circumstances, killing dust mites, especially house dust mites. The lure comprises neryl formate and/or limonene and is usually arranged in powder form to allow it to be shaken over an area containing the mites. What about liquid that dries.

IPC Classes  ?

• A01N 25/00 - Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of applicationSubstances for reducing the noxious effect of the active ingredients to organisms other than pests

Abstract

The present invention relates to a transfer vector for inserting a gene into a genetic locus of a baculovirus sequence. The transfer vector comprises an expression cassette comprising a eukaryotic promoter operably linked to the gene and a bipartite selection cassette. The present invention also relates to methods of using the transfer vector and derived bacmids and baculoviruses.

IPC Classes  ?

• C12N 15/866 - Baculoviral vectors

Abstract

The invention relates to an assay to test for pyrethroids in a sample. The assay i particularly useful for testing material treated with pyrethroids, such as bed netting an the like.

IPC Classes  ?

• G01N 31/22 - Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroupsApparatus specially adapted for such methods using chemical indicators

Abstract

The invention relates to a lure for attracting, and in some circumstances, killing dust mites, especially house dust mites. The lure comprises neryl formate and/or limonene and is usually arranged in powder form to allow it to be shaken over an area containing the mites. What about liquid that dries.

IPC Classes  ?

• A01N 27/00 - Biocides, pest repellants or attractants, or plant growth regulators containing hydrocarbons
• A01N 37/02 - Saturated carboxylic acids or thio-analogues thereofDerivatives thereof
• A01P 19/00 - Pest attractants

Abstract

The invention relates to a method for producing a modified viral strain of a virus which is a member of the Reoviridae family and, in particular, relates to vaccinal viral strains of the Orbivirus genus.

IPC Classes  ?

• C12N 7/04 - Inactivation or attenuationProducing viral sub-units
• C07K 14/14 - Reoviridae, e.g. rotavirus, bluetongue virus, Colorado tick fever virus
• A61K 35/76 - VirusesSubviral particlesBacteriophages
• A61K 39/15 - Reoviridae, e.g. calf diarrhea virus
• A61K 48/00 - Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseasesGene therapy
• C12N 15/86 - Viral vectors

Abstract

The invention relates to a method for producing a modified viral strain of a virus which is a member of the Reoviridae family and, in particular, relates to vaccinal viral strains of the Orbivirus genus.

IPC Classes  ?

• C12N 7/04 - Inactivation or attenuationProducing viral sub-units
• A61K 39/15 - Reoviridae, e.g. calf diarrhea virus
• C07K 14/14 - Reoviridae, e.g. rotavirus, bluetongue virus, Colorado tick fever virus
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
• C12N 7/01 - Viruses, e.g. bacteriophages, modified by introduction of foreign genetic material
• C12N 15/46 - Reoviridae, e.g. rotavirus, bluetongue virus, Colorado tick fever virus
• C12N 15/86 - Viral vectors
• C12Q 1/70 - Measuring or testing processes involving enzymes, nucleic acids or microorganismsCompositions thereforProcesses of preparing such compositions involving virus or bacteriophage

Abstract

The invention relates to the use of volatile organic compounds as markers in the detection of the presence of Mycobacteria especially Mycobacterium tuberculosis. The invention provides a number of compounds useful as markers. Such compounds are frequently emitted by samples containing Mycobacteria and their presence, particularly at increased levels may be used to detect the presence of the bacteria. Also provided is a diagnostic test for tuberculosis, based upon the presence of the bacteria.

IPC Classes  ?

• C12Q 1/04 - Determining presence or kind of microorganismUse of selective media for testing antibiotics or bacteriocidesCompositions containing a chemical indicator therefor

Abstract

The present invention relates to a virus-like particle (VLP) comprising structural proteins from the rift valley fever virus (RVFV). The present invention also relates to a RVFV nucleocapsid-like structure (NLS). The present invention also relates to methods of generating the VLP and NLS, and methods of using the VLP and NLS.

IPC Classes  ?

• C12N 15/866 - Baculoviral vectors
• C12N 7/04 - Inactivation or attenuationProducing viral sub-units
• C07K 14/175 - Bunyaviridae, e.g. California encephalitis virus, Rift valley fever virus, Hantaan virus
• A61K 39/00 - Medicinal preparations containing antigens or antibodies
• A61K 39/12 - Viral antigens
• C12N 5/10 - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells